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Gene 1 Gene 2 Interaction Type Sentence Value Judge me
MAPK tau associate1 These findings indicate that MAPK ERK-P , SAPK JNK-P and p-38-P are differentially expressed in association with tau deposits in tauopathies . 19 good bad
MAPK CREB bind1 Transfection with dominant negative ( dn ) forms of CREB and C EBP , the two CRE-binding transcription factors targeted by the p38 MAPK pathway , resulted in opposite effects i . 17 good bad
MAPK JNK interact1 Stress-activated protein kinase ( SAPK ) pathway-regulating phosphatase 1 ( SKRP1 ) has been identified as a member of the mitogen-activated protein kinase ( MAPK ) phosphatase ( MKP ) family that int 17 good bad
MAPK rin interact1 Mutations in rin G3BP genetically interact with components of the Ras signaling pathway that function at the level of Ras and above , but not with Raf MAPK pathway components . 17 good bad
MAPK JNK complex2 The upstream JNK activators apoptosis signal-regulating kinase 1 ( ASK1 ) and mitogen-activated protein kinase ( MAPK ) kinase 4 were also found in complex with beta-arrestin 2 . 16 good bad
MAPK JNK complex2 Wortmannin-mediated activation of the SAPK JNK and p38 MAPK pathways also resulted in the mobilization of activator protein-1 complex to the nuclear compartment . 15 good bad
MAPK AP-1 bind1 This Lf-induced AP-1 DNA binding activity was reduced by a p38 MAPK inhibitor . 14 good bad
MAPK blr1 complex2 Upstream signaling requirements of retinoic acid ( RA ) -induced blr1 expression and downstream signaling consequences of blr1 over-expression in a human myeloid leukemia cell line demonstrate that mi 14 good bad
MAPK IKK interact2 Kinase assays indicated that ATA inhibited IkappaB kinase ( IKK ) , extracellular signal-regulated kinase ( ERK ) , and p38 mitogen-activated protein kinase ( MAPK ) activity both in vivo and in vitro 14 good bad
MAPK lipoxygenase bind3 The oxidized lipid and lipoxygenase product 12 ( S ) -hydroxyeicosatetraenoic acid induces hypertrophy and fibronectin transcription in vascular smooth muscle cells via p38 MAPK and cAMP response elem 14 good bad
MAPK PTEN interact3 Interactions of PPARgamma with X-RARalpha , protein kinase R ( PKR ) , PTEN , and mitogen-activated protein kinase ( MAPK ) have been described . 14 good bad
MAPK ang bind1 Co-incubation with ang II and high glucose had no additive effect on TGF-beta1 promoter activity , protein binding to the AP-1 box B or activation of p38 MAPK . 13 good bad
MAPK ANG interact3 The molecular mechanism ( s ) of insulin action is mediated , at least in part , via interaction of the functional IRE with unidentified 48- and 70- kDa nuclear proteins in the rat ANG gene and is MAP 13 good bad
MAPK CREB bind1 Here , we have investigated the effects of stress on the expression of three members of the MAPK extracellular-regulated kinase ( ERK ) pathway such as phospho-ERK1 , phospho-ERK2 and phospho-cAMP c 13 good bad
MAPK ERK associate3 Contrary to our expectations , ERK and JNK , the MAPK pathways traditionally associated with cell growth and perhaps malignant transformation , were not consistently activated in the human lung tumor 13 good bad
MAPK ERK1 bind3 These results suggest that the nPKC isoforms produce a unique shift in MAPK activity , via a Ras , MEKK1 , MEK3 pathway , to increase p38delta and inhibit ERK1 2 , and ultimately increase C EBPalpha 13 good bad
MAPK JNK interact1 Stress-activated protein kinase ( SAPK ) pathway-regulating phosphatase 1 ( SKRP1 ) has been identified as a member of the mitogen-activated protein kinase ( MAPK ) phosphatase ( MKP ) family that int 13 good bad
MAPK MK2 bind1 Mitogen-activated protein kinase ( MAPK ) -activated protein kinase 2 ( MK2 ) is activated upon stress by p38 MAPKalpha and -beta , which bind to a basic docking motif in the C terminus of MK2 and whi 13 good bad
MAPK Myt1 interact1 We have found that Myt1 is likely to be the Mos target in this process , as Mos interacts with Myt1 in oocyte extracts and Mos triggers Myt1 phosphorylation on some sites in vivo , even in the absence 13 good bad
MAPK PKA complex1 CONCLUSION : These findings show that the stimulation of NO production by IL-17 is mediated mainly by a complex activation of kinases , especially PKA , NF-kappaB , and MAPK . 13 good bad
MAPK PKC complex2 Together , the data suggest that DA activated MAPK ERK via Ras , Raf-1 kinase , and DAG-dependent PKC isoenzymes , but , importantly and contrary to the classical model , this pathway did not involve 13 good bad
MAPK Epo bind1 In FDCER cell lines , which express endogenous c-Kit , the signaling capacities of such minimal Epo receptor forms ( ER-HY343 and ER-HY343F ) have been dissected to reveal : 1 ) that Epo-dependent mit 12 good bad
MAPK ERK1 bind3 These results suggest that the nPKC isoforms produce a unique shift in MAPK activity , via a Ras , MEKK1 , MEK3 pathway , to increase p38delta and inhibit ERK1 2 , and ultimately increase C EBPalpha 12 good bad
MAPK HOG1 complex2 The recent discovery of two other MAPK subtypes , the JNK SAPK subfamily and p38 RK ( mammalian equivalents of HOG1 in yeast ) , reveals extreme complexity within the family and , most intriguingly 12 good bad
MAPK MUK bind1 MAPK upstream kinase ( MUK ) -binding inhibitory protein , a negative regulator of MUK dual leucine zipper-bearing kinase leucine zipper protein kinase . 12 good bad
MAPK plasmin bind3 Here we demonstrate that in human primary monocytes plasmin stimulates mitogen-activated protein kinase ( MAPK ) signaling via phosphorylation of MAPK kinase ( MKK ) 3 6 and p38 MAPK that triggers su 12 good bad
MAPK rho bind1 Because p65PAK is known to be upstream of p38MAPK and also be a target of p21rac-1 , which belongs to the rho subfamily of p21ras-related small GTP-binding proteins , these results strongly suggested 12 good bad
MAPK AP-1 bind1 The AP-1 complex contained phosphorylated c-Jun and ATF2 and its DNA binding activity was blocked by the p38 MAPK inhibitor SB203580 . 11 good bad
MAPK CBP bind1 Here we show that transcriptional activation of an AP1-regulated gene through the mitogen-activated protein kinase ( MAPK ) -extracellular signal-regulated kinase ( ERK ) pathway ( MAPK ( ERK ) ) is c 11 good bad
MAPK ERK bind1 A docking domain in extracellular-signal-regulated kinase ( ERK ) , a MAPK , serves as a common site for binding to the MAPK kinase MEK1 , the MAPK-activated protein kinase MNK1 and the MAPK phosphata 11 good bad
mapk JNK complex1 The inhibitory effect of p38 ( mapk ) appears more complex and may be due to the ability of p38 ( mapk ) to inhibit LPS-induced JNK activation . 11 good bad
MAPK TFI interact3 In these cells , the physical interaction between COUP-TFI and hERalpha increases the affinity of hERalpha for ERK2 p42 ( MAPK ) , resulting in an enhanced phosphorylation state of the hERalpha Ser11 11 good bad
MAPK p42 bind2 Binding of chemokines to their receptors on leukocytes leads to the activation of heterotrimeric G proteins that initiate multiple signaling cascades , including p38 and p42 p44 mitogen-activated pro 10 good bad
MAPK Ras bind1 The Ras family of GTP-binding proteins are key transducers of extracellular signals , particularly through the mitogen-activated protein kinase ( MAPK ) pathway . 10 good bad
MAPK RXR bind1 How IL-1beta signaling leads to reduced RXR : RAR nuclear binding activity is unknown , and we sought to determine if mitogen activated protein kinase ( MAPK ) pathways were involved . 10 good bad
MAPK Bad associate2 These effects were blocked by U0126 , a mitogen-activated protein kinase Erk kinase 1 2 inhibitor , suggesting an association between Bad phosphorylation and MAPK activation . 9 good bad
MAPK EGFR bind1 The EGFR is a receptor tyrosine kinase , and after binding of its ligand , it triggers several intracellular signaling cascades , among them the one activating the mitogen-activated protein kinases ( 9 good bad
MAPK Erk associate3 However , while pretreatment of U937 cells with the kinase inhibitors PD98059 and SB203580 abrogated the osmotic activation of Erk and p38 MAPK , respectively , it did not prevent the associated stimu 9 good bad
MAPK p38 associate1 Mitogen-activated protein kinase ( MAPK ) signaling cascades trigger stimulus-specific responses in cells with ERK being associated with proliferation and differentiation , and JNK SAPK and p38 media 9 good bad
MAPK calcineurin associate3 Recently many reports have revealed that calcineurin and stress activated protein kinase ( SAPK ) p38-mitogen activated protein kinase ( MAPK ) hypertrophic signalling pathways are associated with th 8 good bad
MAPK PI associate3 Thrombin-mediated MAPK activation was modulated by PI-PLC , Ca2 + , PKC , tyrosine kinase , and PI 3-kinase associated with cell proliferation in canine cultured TSMCs . 8 good bad
MAPK p42 complex1 This tethered receptor complex enables coincident integrative signalling to p42 p44 MAPK . 7 good bad
MAPK PI interact3 The interactions between the phosphatidylinositol 3-kinase ( PI 3-kinase ) and Ras MAPK kinase pathways have been the subject of considerable interest . 6 good bad
MAPK Trk bind1 Although a previous study suggested that ShcB and ShcC do not strongly interact with the Trk receptors ( 1 ) , we find that ShcB and ShcC bind the Trk receptors in a phosphotyrosine dependent manner v 5 good bad
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Text2Knowledge ... Yong Huang 2002