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Gene 1 Gene 2 Interaction Type Sentence Value Judge me
Smad Brk bind1 Brk bound to a Dpp response element of the Ultrabithorax ( Ubx ) midgut enhancer at a sequence that overlaps a binding site for the Smad protein , Mothers Against Dpp ( Mad ) . 21 good bad
Smad Smad4 bind1 While there are two potential Smad binding elements ( SBE ' s ) in the TGFbeta ( 1 ) promoter , supershift assays suggest that at least one of these does not bind Smad4 , and the other is unable to bi 19 good bad
Smad Brk complex1 In addition to the ligand-activated heteromeric receptor complex and the signal-transducing intracellular Smad proteins , Dpp signaling requires two nuclear proteins , Schnurri ( Shn ) and Brinker ( B 18 good bad
Smad neu associate1 Loss of Smad signaling was not associated with any particular histological subtype , histological or nuclear grade , estrogen- or progesterone receptor expression , or HER2 neu expression . 17 good bad
Smad tinman interact3 A similar regulatory interaction has been defined in Drosophila embryos where Dpp signaling mediated by the Smad homologues Mad and Medea directly regulates early cardiac expression of tinman . 17 good bad
Smad tinman bind2 We show that the binding and synergistic activities of Smad and Tinman proteins are critical for mesodermal tinman induction , whereas repressor binding sites prevent induction in the dorsal ectoderm 16 good bad
Smad BRCA2 associate2 Finally , analysis of a small cohort of hereditary breast cancers failed to reveal any association between BRCA1 or BRCA2 genotype and alterations in Smad signaling . 15 good bad
Smad Smad4 complex3 Smad proteins activated by TGF-beta form complexes with Smad4 . 8 good bad
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Text2Knowledge ... Yong Huang 2002