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Gene 1 Gene 2 Interaction Type Sentence Value Judge me
Wnt Axin bind1 In attempting to clarify the roles of Dvl in the Wnt signaling pathway , we identified a novel protein which binds to the PDZ domain of Dvl and named it Idax ( for inhibition of the Dvl and Axin compl 7 good bad
Wnt Axin bind1 In attempting to clarify the roles of Dvl in the Wnt signaling pathway , we identified a novel protein which binds to the PDZ domain of Dvl and named it Idax ( for inhibition of the Dvl and Axin compl 6 good bad
Wnt Axin complex1 PP2C exists in a complex with Dvl , beta-catenin , and Axin , a negative regulator of Wnt signaling . 5 good bad
Wnt Axin complex1 PP2C exists in a complex with Dvl , beta-catenin , and Axin , a negative regulator of Wnt signaling . 5 good bad
Wnt catenin complex2 Wnt signals interfere with beta-catenin turnover , resulting in enhanced transcription of target genes through the increased formation of beta-catenin complexes containing TCF transcription factors . 5 good bad
wnt dishevelled interact3 Interaction of dishevelled and Xenopus axin-related protein is required for wnt signal transduction . 5 good bad
Wnt PP2A bind1 Different subunits of PP2A bind to Axin and Adenomatous Polyposis Coli , components of the Wnt signal transduction pathway . 5 good bad
Wnt PP2A bind1 Different subunits of PP2A bind to Axin and Adenomatous Polyposis Coli , components of the Wnt signal transduction pathway . 5 good bad
Wnt Akt associate1 Therefore , Akt acts in association with Dvl as an important regulator of the Wnt signaling pathway . 4 good bad
Wnt Axin interact1 Other components of the Wnt signalling pathway , including Dvl , glycogen synthase kinase-3beta , beta-catenin , and adenomatous polyposis coli , interact with Axin , and the phosphorylation and stabi 4 good bad
Wnt Dishevelled interact2 Our results indicate that different Wnt Fz signals activate distinct intracellular pathways , and Dishevelled discriminates among them by distinct domain interactions . 4 good bad
wnt dishevelled interact3 Interaction of dishevelled and Xenopus axin-related protein is required for wnt signal transduction . 4 good bad
Wnt integrin bind2 The integrin-dependent binding of deep cells to fibronectin is sufficient to drive membrane localization of Dishevelled-GFP , suggesting that a convergence of integrin and Wnt signaling pathways acts 4 good bad
Wnt Axin complex1 CKIepsilon forms a complex with Axin and the other downstream components of the Wnt pathway . 3 good bad
Wnt Axin interact1 Other components of the Wnt signaling pathway , including Dvl , glycogen synthase kinase-3beta ( GSK-3beta ) , beta-catenin , and adenomatous polyposis coli ( APC ) , interact with Axin , and the phos 3 good bad
Wnt Axin interact1 Other components of the Wnt signalling pathway , including Dvl , glycogen synthase kinase-3beta , beta-catenin , and adenomatous polyposis coli , interact with Axin , and the phosphorylation and stabi 3 good bad
Wnt Dishevelled interact2 Our results indicate that different Wnt Fz signals activate distinct intracellular pathways , and Dishevelled discriminates among them by distinct domain interactions . 3 good bad
Wnt Axin complex1 CKIepsilon forms a complex with Axin and the other downstream components of the Wnt pathway . 2 good bad
Wnt catenin complex2 Wnt signals interfere with beta-catenin turnover , resulting in enhanced transcription of target genes through the increased formation of beta-catenin complexes containing TCF transcription factors . 2 good bad
Wnt Tcf interact1 Upon binding of a Wnt to its receptor , GSK3beta is inhibited through an unknown mechanism involving Dishevelled ( Dsh ) , resulting in the dephosphorylation and stabilization of beta-catenin , which 2 good bad
Wnt Tcf interact1 Upon binding of a Wnt to its receptor , GSK3beta is inhibited through an unknown mechanism involving Dishevelled ( Dsh ) , resulting in the dephosphorylation and stabilization of beta-catenin , which 2 good bad
Wnt Axin interact1 Other components of the Wnt signaling pathway , including Dvl , glycogen synthase kinase-3beta ( GSK-3beta ) , beta-catenin , and adenomatous polyposis coli ( APC ) , interact with Axin , and the phos 1 good bad
Wnt catenin complex2 Wnt signal transduction is controlled by the rate of degradation of beta-catenin by a complex of proteins including glycogen synthase kinase 3 ( GSK3 ) , adenomatous polyposis coli , and Axin . 1 good bad
Wnt catenin interact1 These results suggest that rAxin negatively regulates the Wnt signaling pathway by interacting with GSK-3beta and beta-catenin and mediating the signal from GSK-3beta to beta-catenin . 1 good bad
WNT decapentaplegic interact1 Moreover the wingless WNT pathway displays antagonistic interactions with the DPP ( decapentaplegic ) pathway , which regulates branching along the dorsoventral axis . 1 good bad
Wnt catenin interact1 These results suggest that rAxin negatively regulates the Wnt signaling pathway by interacting with GSK-3beta and beta-catenin and mediating the signal from GSK-3beta to beta-catenin . -3 good bad
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Text2Knowledge ... Yong Huang 2002