BI221 Mitochondriomics

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==Background==
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==Objectives==
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Mitochondria are semi-autonomous organelles, presumed to be the evolutionary product of a symbiosis between a eukaryote and a prokaryote. The organelle is present in almost all eukaryotic cells in an extent from 10^3-10^4 copies. The main function of mitochondria is production of ATP by oxidative phosphorylation and its involvement in apoptosis. The organelles contain almost exclusively maternally inherited mtDNA, and they have specific systems for transcription, translation and replication of mtDNA.
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Mitochondrial dysfunction has been correlated with diseases where clinical pathologies include infertility, diabetes, blindness, deafness, stroke, migraine, plus heart, kidney, and liver diseases. Recently, cancer was added to this list when investigations into human cancer cells from breast, bladder, neck and lung revealed a high occurrence of mutations in mtDNA. With the emerging understanding of the role of mitochondria in a vast array of pathologies, research into this organelle and its dysfunction has yielded a vast amount of data in the last decade in the form of publications and databases. Nevertheless, the field of mitochondrial research is still far from exhausted, with many unknown factors yet to be discovered.
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Mitochondrial dysfunction has been correlated with mitochondrial diseases where the clinical pathologies are believed to include infertility, diabetes, blindness, deafness, stroke, migraine and heart-, kidney-, and liver diseases. Recently cancer was added to this list when investigations into human cancer cells from breast, bladder, neck, and lung, revealed a high occurrence of mutations in mtDNA. With the emerging understanding of the role of mitochondria in a vast array of pathologies, research of mitochondria and mitochondrial dysfunction have in the last decade yielded a huge amount of data in form of publications and databases. Nevertheless, the field of mitochondrial research is still far from exhausted with many unknown factors yet to be discovered.
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The purpose of this course is to introduce the student to the various databases and wet-lab methods available. Furthermore, the course will, through selected articles, give an understanding of the pitfalls and limitations of such resources.
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==Objective==
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The purpose of this course is to introduce the student to the various databases and wet-lab methods available. Furthermore, the course will, through selected articles, give an understanding of the pitfalls and limitations of the various databases and methods.
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==Instructors==
==Instructors==
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* [http://ljr-lab.ruc.dk/xoops/modules/xroster/index.php?op=View&id=2&PHPSESSID=34840d6f26dbe7539de884c4a1077632 Claus Desler] ([mailto:cdesler@ruc.dk cdesler@ruc.dk])
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[[Prash|Prashanth Suravajhala]]
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* [http://ruc.dk/~prash Prashanth Suravajhala] ([mailto:prash@ruc.dk prash@ruc.dk])
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==Course outline==
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* Day 1: Introduction to mitochondria and its pathways, genetics; proteomics of mitochondria
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* Day 2: Various assays used and advances in mitochondrial research
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* Day 3: Tools and databases used in mitochondrial research; exercises
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* Day 4: Exercises, report, review of literature continues
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Additionally, [http://icmm.ku.dk/english/icmm-staff/claus_desler/ Claus Desler] will give a lecture as supplementary material for the course.
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* Day 5: Summary and questions and answers; evaluation
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==Syllabus==
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==Course schedule==
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April 4-8, 2011, Monday/Wednesday/Friday
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Access to completed courses is available to enrolled students only, because of privacy and confidentiality issues. If you are interested in an upcoming course, register using instructions below.
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There will be 2 hours of lecture for each of the 3 days. This course will also include about an hour of supplemental lectures.
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* [http://edu.bioinformatics.org/AAT Course AAT (online), November 5-9, 2007, 16:00-19:00 GMT]
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; Session 1
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==Registration==
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: Introduction to mitochondria and its pathways and genetics, by Prash Suravajhala
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Registration is comprised of two steps. First, if you haven't already done so, [https://edu.bioinformatics.org/login/signup.php create an online account] to access the educational section of our website. Second, register for this course by making a payment using either the online registration form (click on the scheduled course above; ''use this form only for credit card payments via secured PayPal''), or by sending in the [http://edu.bioinformatics.org/download/registration_form.pdf mail-in registration form] (~150 kB PDF, ''use this form if paying by US checks, credit card or corporate purchase order''). Please check the tuition rates and discounts below.
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; Session 2
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Registration deadline: When full
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: Proteomics of mitochondria, by Prash Suravajhala
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===[[Tuition discounts]]===
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; Supplemental
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* Returning student discount: A 20% (rounded up) discount applies for students who have paid the base tuition (without a similar discount) for another course at Bioinformatics.Org (please use the mail-in registration form rather than PayPal if taking this discount).
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: Biochemistry of mitochondrial diseases, by Claus Desler
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: ''Various assays used and advances in mitochondrial research''
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Tuition (all prices USD):
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; Session 3
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        <td style="border-right: solid 1px black; padding: 0.5em;"></td>
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        <td style="border-right: solid 1px black; padding: 0.5em;">Base tuition</td>
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        <td style="">If taken with another course at base tuition</td>
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        <td style="border-right: solid 1px black; padding: 0.5em;">Commercial</td>
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        <td style="border-right: solid 1px black; padding: 0.5em;">$892</td>
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        <td style="">$714</td>
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        <td style="border-right: solid 1px black; padding: 0.5em;">Non-profit/academic</td>
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        <td style="border-right: solid 1px black; padding: 0.5em;">$595</td>
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        <td style="">$476</td>
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</table>
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For full-time students and the unemployed, please inquire about an additional discount (verification required).
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: Tools and databases used in mitochondrial research, by Prash Suravajhala
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==Logistics==
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; Session 4
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Online courses are offered via an online meeting system.  Access information will be provided prior to the start of the course. Each lecture will last 45 to 90 minutes, depending on the topics covered. For those who cannot attend the lectures at those times, the lectures will be recorded and placed on the course website as Flash videos (resolution reduced by 30%) each day, within one day.  Students will also be able to communicate with the instructor and other students via the course forums.  Lecture attendance is therefore not required.
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: Challenges in mitochondrial research, by Prash Suravajhala
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Since this will be an interactive, hands-on workshop, all attendees will need a computer with a broadband Internet connection (1 Mbps or faster is strongly recommended for those watching the live lecture), a sound card with speakers, a modern Web browser, and the [http://www.adobe.com/products/flashplayer/ Adobe Flash plugin].  A microphone and webcam is not required for this course.  The necessary software, lecture notes and exercises will be provided.
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; Session 5
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==Additional information==
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: Mitochondria in aging and diseases,  Prash Suravajhala
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If you have any questions, please send a message to [http://edu.bioinformatics.org/message/discussion.php?id=100003 J.W. Bizzaro] (login required) or call +1 978 562 4800.
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; Session 6
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==See also==
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: Exercises & take home messages, by Prash Suravajhala
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* [[Educational services|Educational services at Bioinformatics.Org]]
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{{Course footer
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Latest revision as of 21:12, 29 February 2012

Contents

Objectives

Mitochondrial dysfunction has been correlated with diseases where clinical pathologies include infertility, diabetes, blindness, deafness, stroke, migraine, plus heart, kidney, and liver diseases. Recently, cancer was added to this list when investigations into human cancer cells from breast, bladder, neck and lung revealed a high occurrence of mutations in mtDNA. With the emerging understanding of the role of mitochondria in a vast array of pathologies, research into this organelle and its dysfunction has yielded a vast amount of data in the last decade in the form of publications and databases. Nevertheless, the field of mitochondrial research is still far from exhausted, with many unknown factors yet to be discovered.

The purpose of this course is to introduce the student to the various databases and wet-lab methods available. Furthermore, the course will, through selected articles, give an understanding of the pitfalls and limitations of such resources.

Instructors

Prashanth Suravajhala

Additionally, Claus Desler will give a lecture as supplementary material for the course.

Syllabus

April 4-8, 2011, Monday/Wednesday/Friday

There will be 2 hours of lecture for each of the 3 days. This course will also include about an hour of supplemental lectures.

Session 1
Introduction to mitochondria and its pathways and genetics, by Prash Suravajhala
Session 2
Proteomics of mitochondria, by Prash Suravajhala
Supplemental
Biochemistry of mitochondrial diseases, by Claus Desler
Various assays used and advances in mitochondrial research
Session 3
Tools and databases used in mitochondrial research, by Prash Suravajhala
Session 4
Challenges in mitochondrial research, by Prash Suravajhala
Session 5
Mitochondria in aging and diseases, Prash Suravajhala
Session 6
Exercises & take home messages, by Prash Suravajhala

Scheduled courses

If you are interested in an upcoming course, register using instructions below. (Access to completed courses is available to enrolled students only, because of privacy and confidentiality issues.)

Registration

Registration for courses at Bioinformatics.Org takes two steps:

Step 1
If you haven't already done so, create an on-line account to access the educational section of our website. Please note that the registration for our educational system is separate from that of the main website; you will require another account.
Step 2
Register for the course by making a payment using either the on-line registration form (click on the name of the course where it appears in the list of upcoming courses; use this form only for PayPal payments and credit card payments via secured PayPal), or by sending in the registration form (PDF; use this form if paying by US checks, credit card or corporate purchase order).

Please also check the course tuition rates and discounts.

Registration deadline: When full

Tuition & discounts

Live instruction held on-line
Live instruction held on-site
On-demand instruction held on-line

Additional discounts are available as follows:

Logistics

The necessary software, lecture notes and exercises will be provided.

Live instruction held on-line

On-line/live courses use the WebEx on-line meeting system. Access information will be provided prior to the start of the course. Unless otherwise noted, each lecture begins at 16:00 GMT and runs for about two hours, depending on the topics covered.

For those who cannot attend the lectures at those times, the lectures will be recorded and placed on the course website as AVI video files each day, within one day. Students will also be able to communicate with the instructor and other students via the course forums. Lecture attendance is therefore not required.

Since this will be an interactive, hands-on workshop, all attendees will need a computer with a broadband Internet connection (1 Mbps or faster is strongly recommended for those watching the live lecture), a sound card with speakers, a modern Web browser, and Java. A microphone and webcam are not required but may be used.

Certification

This course is certified by the Bioinformatics Organization, Inc., the largest international affiliation in the field, and it will count as 6 "Continuing Scientific Education" (CSE) units (one unit per contact hour) within the Organization. Students completing the course will receive a certificate attesting to that.

Refund policy

For any course type, if a student is not satisfied with the conduct or content of a course, they may request a full refund within the first two days of lecture. After two days but within a week, a 50% refund will be granted. After one week, a 100% credit toward another course will be granted. No refunds or credits apply beyond those stated here.

Additional information

Please contact us for questions or additional information.

See also

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