BI221 Mitochondriomics

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==Objectives==
==Objectives==
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Mitochondria are semi-autonomous organelles, presumed to be the evolutionary product of a symbiosis between a eukaryote and a prokaryote. The organelle is present in almost all eukaryotic cells to the extents of 10^3-10^4 copies. The main function of mitochondria is production of ATP by oxidative phosphorylation and its involvement in apoptosis. The organelles contain almost exclusively maternally-inherited mtDNA, and they have specific systems for transcription, translation and replication of mtDNA.
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Mitochondrial dysfunction has been correlated with diseases where clinical pathologies include infertility, diabetes, blindness, deafness, stroke, migraine, plus heart, kidney, and liver diseases. Recently, cancer was added to this list when investigations into human cancer cells from breast, bladder, neck and lung revealed a high occurrence of mutations in mtDNA. With the emerging understanding of the role of mitochondria in a vast array of pathologies, research into this organelle and its dysfunction has yielded a vast amount of data in the last decade in the form of publications and databases. Nevertheless, the field of mitochondrial research is still far from exhausted, with many unknown factors yet to be discovered.
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Mitochondrial dysfunction has been correlated with mitochondrial diseases where the clinical pathologies are believed to include infertility, diabetes, blindness, deafness, stroke, migraine plus heart, kidney, and liver diseases. Recently cancer was added to this list when investigations into human cancer cells from breast, bladder, neck, and lung, revealed a high occurrence of mutations in mtDNA. With the emerging understanding of the role of mitochondria in a vast array of pathologies, research into mitochondria and mitochondrial dysfunction has in the last decade yielded a huge amount of data in the form of publications and databases. Nevertheless, the field of mitochondrial research is still far from exhausted with many unknown factors yet to be discovered.
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The purpose of this course is to introduce the student to the various databases and wet-lab methods available. Furthermore, the course will, through selected articles, give an understanding of the pitfalls and limitations of such resources.
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The purpose of this course is to introduce the student to the various databases and wet-lab methods available. Furthermore, the course will, through selected articles, give an understanding of the pitfalls and limitations of the various databases and methods. This is the second time the course is being taught through Bioinformatics.Org.
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==Instructors==
==Instructors==
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* [http://icmm.ku.dk/english/icmm-staff/claus_desler/ Claus Desler]
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[[Prash|Prashanth Suravajhala]]
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* [http://www.bioinformatics.org/wiki/Prash Prashanth Suravajhala]
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Additionally, [http://icmm.ku.dk/english/icmm-staff/claus_desler/ Claus Desler] will give a lecture as supplementary material for the course.
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==Syllabus==
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April 4-8, 2011, Monday/Wednesday/Friday
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There will be 2 hours of lecture for each of the 3 days. This course will also include about an hour of supplemental lectures.
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; Session 1
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: Introduction to mitochondria and its pathways and genetics, by Prash Suravajhala
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; Session 2
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: Proteomics of mitochondria, by Prash Suravajhala
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; Supplemental
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: Biochemistry of mitochondrial diseases, by Claus Desler
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: ''Various assays used and advances in mitochondrial research''
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==When==
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; Session 3
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March 7-11, 2011
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: Tools and databases used in mitochondrial research, by Prash Suravajhala
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==Course outline==
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; Session 4
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The ten hour course covers the following sub-topics:
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: Challenges in mitochondrial research, by Prash Suravajhala
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* Introduction to mitochondria and its pathways, genetics; proteomics of mitochondria
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; Session 5
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* Various assays used and advances in mitochondrial research
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: Mitochondria in aging and diseases,  Prash Suravajhala
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* Tools and databases used in mitochondrial research
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; Session 6
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* Exercises and take home messages
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: Exercises & take home messages, by Prash Suravajhala
{{Course footer
{{Course footer
|hours=6
|hours=6
}}
}}

Latest revision as of 21:12, 29 February 2012

Contents

Objectives

Mitochondrial dysfunction has been correlated with diseases where clinical pathologies include infertility, diabetes, blindness, deafness, stroke, migraine, plus heart, kidney, and liver diseases. Recently, cancer was added to this list when investigations into human cancer cells from breast, bladder, neck and lung revealed a high occurrence of mutations in mtDNA. With the emerging understanding of the role of mitochondria in a vast array of pathologies, research into this organelle and its dysfunction has yielded a vast amount of data in the last decade in the form of publications and databases. Nevertheless, the field of mitochondrial research is still far from exhausted, with many unknown factors yet to be discovered.

The purpose of this course is to introduce the student to the various databases and wet-lab methods available. Furthermore, the course will, through selected articles, give an understanding of the pitfalls and limitations of such resources.

Instructors

Prashanth Suravajhala

Additionally, Claus Desler will give a lecture as supplementary material for the course.

Syllabus

April 4-8, 2011, Monday/Wednesday/Friday

There will be 2 hours of lecture for each of the 3 days. This course will also include about an hour of supplemental lectures.

Session 1
Introduction to mitochondria and its pathways and genetics, by Prash Suravajhala
Session 2
Proteomics of mitochondria, by Prash Suravajhala
Supplemental
Biochemistry of mitochondrial diseases, by Claus Desler
Various assays used and advances in mitochondrial research
Session 3
Tools and databases used in mitochondrial research, by Prash Suravajhala
Session 4
Challenges in mitochondrial research, by Prash Suravajhala
Session 5
Mitochondria in aging and diseases, Prash Suravajhala
Session 6
Exercises & take home messages, by Prash Suravajhala

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