BI221 Mitochondriomics

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==Objectives==
==Objectives==
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Mitochondria are semi-autonomous organelles, presumed to be the evolutionary product of a symbiosis between a eukaryote and a prokaryote. The organelle is present in almost all eukaryotic cells in an extent from 10^3-10^4 copies. The main function of mitochondria is production of ATP by oxidative phosphorylation and its involvement in apoptosis. The organelles contain almost exclusively maternally inherited mtDNA, and they have specific systems for transcription, translation and replication of mtDNA.
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Mitochondria are semi-autonomous organelles, presumed to be the evolutionary product of a symbiosis between a eukaryote and a prokaryote. The organelle is present in almost all eukaryotic cells to the extents of 10^3-10^4 copies. The main function of mitochondria is production of ATP by oxidative phosphorylation and its involvement in apoptosis. The organelles contain almost exclusively maternally-inherited mtDNA, and they have specific systems for transcription, translation and replication of mtDNA.
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Mitochondrial dysfunction has been correlated with mitochondrial diseases where the clinical pathologies are believed to include infertility, diabetes, blindness, deafness, stroke, migraine and heart-, kidney-, and liver diseases. Recently cancer was added to this list when investigations into human cancer cells from breast, bladder, neck, and lung, revealed a high occurrence of mutations in mtDNA. With the emerging understanding of the role of mitochondria in a vast array of pathologies, research of mitochondria and mitochondrial dysfunction have in the last decade yielded a huge amount of data in form of publications and databases. Nevertheless, the field of mitochondrial research is still far from exhausted with many unknown factors yet to be discovered.
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Mitochondrial dysfunction has been correlated with mitochondrial diseases where the clinical pathologies are believed to include infertility, diabetes, blindness, deafness, stroke, migraine plus heart, kidney, and liver diseases. Recently cancer was added to this list when investigations into human cancer cells from breast, bladder, neck, and lung, revealed a high occurrence of mutations in mtDNA. With the emerging understanding of the role of mitochondria in a vast array of pathologies, research into mitochondria and mitochondrial dysfunction has in the last decade yielded a huge amount of data in the form of publications and databases. Nevertheless, the field of mitochondrial research is still far from exhausted with many unknown factors yet to be discovered.
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The purpose of this course is to introduce the student to the various databases and wet-lab methods available. Furthermore, the course will, through selected articles, give an understanding of the pitfalls and limitations of the various databases and methods. This is the second time the course is to be taught through Bioinformatics.org
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The purpose of this course is to introduce the student to the various databases and wet-lab methods available. Furthermore, the course will, through selected articles, give an understanding of the pitfalls and limitations of the various databases and methods. This is the second time the course is being taught through Bioinformatics.Org.
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For further details, [http://www.bioinformatics.org/edu/AAGA please click here]
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==Instructors==
==Instructors==
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==When==
==When==
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March 7-11, 2011 : 10 hours course.
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March 7-11, 2011
==Course outline==
==Course outline==
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The ten hour course covers the following sub-topics:
The ten hour course covers the following sub-topics:
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*Introduction to mitochondria and its pathways, genetics; proteomics of mitochondria
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* Introduction to mitochondria and its pathways, genetics; proteomics of mitochondria
* Various assays used and advances in mitochondrial research
* Various assays used and advances in mitochondrial research
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* Tools and databases used in mitochondrial research
* Tools and databases used in mitochondrial research
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*Exercises and take home messages
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* Exercises and take home messages
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{{Course footer
{{Course footer
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|hours=6
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Revision as of 22:11, 26 February 2011

Contents

Objectives

Mitochondria are semi-autonomous organelles, presumed to be the evolutionary product of a symbiosis between a eukaryote and a prokaryote. The organelle is present in almost all eukaryotic cells to the extents of 10^3-10^4 copies. The main function of mitochondria is production of ATP by oxidative phosphorylation and its involvement in apoptosis. The organelles contain almost exclusively maternally-inherited mtDNA, and they have specific systems for transcription, translation and replication of mtDNA.

Mitochondrial dysfunction has been correlated with mitochondrial diseases where the clinical pathologies are believed to include infertility, diabetes, blindness, deafness, stroke, migraine plus heart, kidney, and liver diseases. Recently cancer was added to this list when investigations into human cancer cells from breast, bladder, neck, and lung, revealed a high occurrence of mutations in mtDNA. With the emerging understanding of the role of mitochondria in a vast array of pathologies, research into mitochondria and mitochondrial dysfunction has in the last decade yielded a huge amount of data in the form of publications and databases. Nevertheless, the field of mitochondrial research is still far from exhausted with many unknown factors yet to be discovered.

The purpose of this course is to introduce the student to the various databases and wet-lab methods available. Furthermore, the course will, through selected articles, give an understanding of the pitfalls and limitations of the various databases and methods. This is the second time the course is being taught through Bioinformatics.Org.

Instructors

When

March 7-11, 2011

Course outline

The ten hour course covers the following sub-topics:

Scheduled courses

If you are interested in an upcoming course, register using instructions below. (Access to completed courses is available to enrolled students only, because of privacy and confidentiality issues.)

Registration

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Step 1
If you haven't already done so, create an on-line account to access the educational section of our website. Please note that the registration for our educational system is separate from that of the main website; you will require another account.
Step 2
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Please also check the course tuition rates and discounts.

Registration deadline: When full

Tuition & discounts

Live instruction held on-line
Live instruction held on-site
On-demand instruction held on-line

Additional discounts are available as follows:

Logistics

The necessary software, lecture notes and exercises will be provided.

Live instruction held on-line

On-line/live courses use the WebEx on-line meeting system. Access information will be provided prior to the start of the course. Unless otherwise noted, each lecture begins at 16:00 GMT and runs for about two hours, depending on the topics covered.

For those who cannot attend the lectures at those times, the lectures will be recorded and placed on the course website as AVI video files each day, within one day. Students will also be able to communicate with the instructor and other students via the course forums. Lecture attendance is therefore not required.

Since this will be an interactive, hands-on workshop, all attendees will need a computer with a broadband Internet connection (1 Mbps or faster is strongly recommended for those watching the live lecture), a sound card with speakers, a modern Web browser, and Java. A microphone and webcam are not required but may be used.

Certification

This course is certified by the Bioinformatics Organization, Inc., the largest international affiliation in the field, and it will count as 6 "Continuing Scientific Education" (CSE) units (one unit per contact hour) within the Organization. Students completing the course will receive a certificate attesting to that.

Refund policy

For any course type, if a student is not satisfied with the conduct or content of a course, they may request a full refund within the first two days of lecture. After two days but within a week, a 50% refund will be granted. After one week, a 100% credit toward another course will be granted. No refunds or credits apply beyond those stated here.

Additional information

Please contact us for questions or additional information.

See also

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