BI221 Mitochondriomics

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Mitochondria are semi-autonomous organelles, presumed to be the evolutionary product of a symbiosis between a eukaryote and a prokaryote. The organelle is present in almost all eukaryotic cells in an extent from 10^3-10^4 copies. The main function of mitochondria is production of ATP by oxidative phosphorylation and its involvement in apoptosis. The organelles contain almost exclusively maternally inherited mtDNA, and they have specific systems for transcription, translation and replication of mtDNA.

Mitochondrial dysfunction has been correlated with mitochondrial diseases where the clinical pathologies are believed to include infertility, diabetes, blindness, deafness, stroke, migraine and heart-, kidney-, and liver diseases. Recently cancer was added to this list when investigations into human cancer cells from breast, bladder, neck, and lung, revealed a high occurrence of mutations in mtDNA. With the emerging understanding of the role of mitochondria in a vast array of pathologies, research of mitochondria and mitochondrial dysfunction have in the last decade yielded a huge amount of data in form of publications and databases. Nevertheless, the field of mitochondrial research is still far from exhausted with many unknown factors yet to be discovered.

The purpose of this course is to introduce the student to the various databases and wet-lab methods available. Furthermore, the course will, through selected articles, give an understanding of the pitfalls and limitations of the various databases and methods. This is the second time the course is to be taught through

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March 7-11, 2011 : 10 hours course.

Course outline

The ten hour course covers the following sub-topics:

Scheduled courses

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Tuition & discounts

Live instruction held on-line
Live instruction held on-site
On-demand instruction held on-line

Additional discounts are available as follows:


The necessary software, lecture notes and exercises will be provided.

Live instruction held on-line

On-line/live courses use the WebEx on-line meeting system. Access information will be provided prior to the start of the course. Unless otherwise noted, each lecture begins at 16:00 GMT and runs for about (please inquire), depending on the topics covered.

For those who cannot attend the lectures at those times, the lectures will be recorded and placed on the course website as AVI video files each day, within one day. Students will also be able to communicate with the instructor and other students via the course forums. Lecture attendance is therefore not required.

Since this will be an interactive, hands-on workshop, all attendees will need a computer with a broadband Internet connection (1 Mbps or faster is strongly recommended for those watching the live lecture), a sound card with speakers, a modern Web browser, and Java. A microphone and webcam are not required but may be used.


This course is certified by the Bioinformatics Organization, Inc., the largest international affiliation in the field, and it will count as 5 "Continuing Scientific Education" (CSE) units (one unit per contact hour) within the Organization. Students completing the course will receive a certificate attesting to that.

Refund policy

For any course type, if a student is not satisfied with the conduct or content of a course, they may request a full refund within the first two days of lecture. After two days but within a week, a 50% refund will be granted. After one week, a 100% credit toward another course will be granted. No refunds or credits apply beyond those stated here.

Additional information

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See also

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