Gary Van Domselaar

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Bioinformatics.Org

I am a founding member and Associate Director of The Bioinformatics Organization, Inc. Bioinformatics.Org was founded to facilitate world-wide communications and collaborations between practicing and neophyte bioinformatic scientists and technicians. The Organization provides these individuals, as well as the public at large, free and open access to materials and methods for and from scientific research, software development, and education. We advocate and promote freedom and openness in the field as well as provide a forum for activities which facilitate the development of such resources. Bioinformatics.Org was established in 1998 by J.W. Bizzaro as a place to host collaborations in bioinformatics. I joined as a cofounder in early 1999 . In 2000, the Organization had more than 100 members and over one dozen projects. The Organization became incorporated in 2003 and currently has more than 26,000 members and over 400 projects. Bioinformatics.Org is one of the largest affiliations in the field of bioinformatics, and the number of resources that we offer is on-par with that offered by NCBI and EBI. However, we distinguish ourselves with our open membership and project hosting: anyone, anywhere can participate. Bioinformatics.Org is also well-known for its emphasis on open access to biological information as well as on Free and Open Source software.

Affliliations

The National Microbiology Lab

I am currently the head of Bioinformatics at Canada's National Microbiology Laboratory. My principal expertise is in microbial (viral and bacterial) bioinformatics. My group is actively involved in a wide range of genomic, proteomic, and bioinformatic research and technology projects. My current work focuses on the development of systems and software for viral and bacterial sequence assembly, sequence finishing, and taxonomic classification. Other activities include metagenomics, bacterial sequence annotation and analysis, pathogen identification, comparative genomics, proteome bioinformatics, and pathogenomics.

Faculty of Pharmacy, University of Alberta

I am an Adjunct Professor of Pharmacy at the University of Manitoba in Canada. I lecture on bioinformatics to students in various disciplines at the UofM, and serve on the UofM bioinformatics curriculum development committee. I also teach modules in proteomics and genomics at the National Bioinformatics Node of South Africa. I am a former lecturer at the Canadian Bioinformatics Workshops series in bioinformatics, proteomics, and genomics.

Education

I received my PhD in Pharmacy and Pharmaceutical Sciences in 2003 at the University of Alberta in Edmonton, Canada. I worked as a Post Doctoral Fellow in Bioinformatics in Computing Science, also at the University of Alberta, from 2003 until 2005.

Refereed papers

Chiang S, Burch T, Van Domselaar G, Radziwon A, Dick K, Brusnyk C, Cutts T, Cao X, Li X and He R (2008) The Interaction between T:G Mismatch Repair Enzyme Thymine DNA Glycosylase and Nuclear Receptor Coactivator 3 is Important for the Transcriptional Activation of Nuclear Hormone Receptors Biochemistry (in press).

Chun S, Li C, Van Domselaar G, Wang J, Farnsworth A , Cui X, Rode H, . Cyr TD, He R. and Li X. (2008) Universal antibodies and their applications to the quantitative determination of virtually all subtypes of the influenza A viral hemagglutinins. Vaccine 26:6068-6076. PDF|PubMed

Liang B, Luo M, Ball TB, Yao X, Van Domselaar G, Cuff WR, Cheang M, Jones SJM and Plummer FA (2008) Systematic Analysis of Host Immunological Pressure on the Envelope Gene of Human Immunodeficiency Virus Type 1 by an Immunological Bioinformatics Approach. Current HIV Research 6:370-379. PDF|PubMed

Falzarano D. Krokhin O, Van Domselaar G, Wolf K, Seebach J, Schnittler HJ, and Feldmann H (2007) Ebola virus sGP - the first viral glycoprotein shown to be C-mannosylated. Virology 368:83-90. PDF|PubMed

Gilmour MW, Bernard K, Tracz DM, Olson AB, Corbett CR, Burdz T, Ng B, Wiebe D, Broukhanski G, Beleszczuk P, Tang P, Jamieson F, Van Domselaar G, Plummer F, and Berry JD (2007) Molecular typing of a Legionella pneumophila outbreak in Ontario, Canada. Journal of Medical Microbiology, 56:336–341. PDF|PubMed

Davies MR, McMillan DJ, Van Domselaar GH, Jones MK, and Sriprakash S (2007) Phage 3396 (φ 3396) from a Streptococcus dysgalactiae subspecies 1 equisimilis pathovar may have its origins in S pyogenes. J. Bacteriol. 189:2646-52. PDF|PubMed

Gilmour MW, Van Domselaar G and Ng L-K. (2006) Application of Comparative Genomics to Molecular Typing and Diagnostics of Outbreak-associated Bacterial Pathogens. International Journal of Infectious Diseases. 10: S19.

Van Domselaar GH, Stothard P, Shrivastava S, Cruz J, Guo A, Dong X, Lu P, Szafron D, Greiner R, and Wishart DS (2005) BASys: A web server for automated bacterial genome annotation. Nucleic Acids Research 33:W455-W459. PDF|PubMed

Maiti R, Van Domselaar GH, and Wishart DS (2005) MovieMaker: A web server for rapid rendering of protein motions and interactions. Nucleic Acids Research 33:W358-W362. PDF|PubMed

Stothard P, Van Domselaar GH, Shrivastava S, Guo A, O'Neill B, Cruz J, Ellison M, and Wishart DS (2005) BacMap: an interactive picture atlas of annotated bacterial genomes. Nucleic Acids Research 33:D317-D320. PDF|PubMed

Maiti R, Van Domselaar GH, Zhang H, and Wishart DS (2004) SuperPose: A simple server for sophisticated structural superposition. Nucleic Acids Research 32: W590-W594. PDF|PubMed

Van Domselaar GH, Kwon GS, Andrew LC, and Wishart DS (2003) Application of solid phase peptide synthesis to engineering PEO-peptide block copolymers for drug delivery. Surfaces and Colloids B: Biointerfaces 30:323-334. PDF|ScienceDirect

Van Domselaar GH, Okarvi S, Fanta M, Suresh MR, and Wishart DS (2000) Synthesis and 99mTc-labeling of bz-MAG3-triprolinyl peptides, their radiochemical evaluation and in vitro receptor-binding. Journal of Labelled Compounds and Radiopharmaceuticals 43:1192-1204. PDF|Wiley Interscience

Wishart DS, Fortin S, Woloschuk DR, Wong W, Rosborough T, Van Domselaar GH, Schaeffer J, and Szafron D (1997) A Platform Independent Graphical User Interface for SEQSEE and XALIGN. Comput. Applic. Biosci. (Now Bioinformatics) 13:561 562 PDF|PubMed

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