| Protein | Protein Name | Molecular Type | Evidence | Reference |
|---|
| TP53 | Tumor protein p53 | Transcription Factor | TP53 functions as a tumour suppressor and suffers from mutation in prostate cancer. | Reference |
| TP53 | Tumor protein p53 | Transcription Factor | Tumour suppressor TP53 mutations in exon 7 and exon 8 are factors of tumor progression in PCa. | Reference |
| SMAD4 | SMAD family member 4 | Transcription Factor | miR-888 expressions are increased in advanced prostate cancer and miR-888 targets and lowers the expression levels of tumour suppressor SMAD4. | Reference |
| SMAD4 | SMAD family member 4 | Transcription Factor | SMAD4 is a tumor suppressor located on chromosome 18q21.1 and its expression levels are reduced in prostate cancer tissues compared to normal prostate. | Reference |
| WT1 | Wilms tumor 1 | Transcription Factor | Wilm's tumour gene (WT1) function as a tumour suppressor in prostate cancer progression by regulating prostate tumour cell growth. | Reference |
| FOXO1 | Forkhead box O1 | Transcription Factor | Aberrant activation of CDK1 and CDK2 results in phosphorylation and inactivation of FOXO1, inhibiting its tumour suppressive function. | Reference |
| FOXO1 | Forkhead box O1 | Transcription Factor | FOXO1 play a crucial role in prostate cancer tumor suppression by acting as a key downstream effector of PTEN. | Reference |
| RB1 | Retinoblastoma 1 | Transcription Regulatory Protein | RB1 function as a tumour suppressor gene in prostate cancer as RB1 loss induces E2F1 mediated deregulation of the AR locus. | Reference |
| SMAD3 | SMAD family member 3 | Transcription Regulatory Protein | TGF beta induced SMAD3 mediated signaling have a tumor suppressive activity in castration resistant prostate cancer. | Reference |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | GTPase | RAC1 is involved in Cyclin D1 mediated cell cycle regulation through PAK1 in androgen independent prostate cancer cell. | Reference |
| SMAD2 | SMAD family member 2 | DNA Binding Protein | SMAD2 functions as a tumor suppressor in basal epithelia of prostate cancer NRP-152 cells. | Reference |
| SMAD2 | SMAD family member 2 | DNA Binding Protein | TGF beta induced SMAD2 mediated signalling have a tumor suppressive activity in castration resistant prostate cancer. | Reference |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | Adaptor Protein | DAB2 functions as a potent tumour suppressor in prostate cancer; functions as a negative regulator of cell growth. | Reference |
| BIN1 | Bridging integrator 1 | Adaptor Protein | BIN1 is the chromosome 2q prostate tumour suppressor gene and frequently deleted in metastatic prostate cancer; Its inactivation contributes to the enhancement of c-MYC mediated oncogenic function . | Reference |
| ANK1 | Ankyrin 1, erythrocytic | Adaptor Protein | ANK1 tumour suppressor present on 8p22 is frequently deleted in both metastatic and localized prostate cancer specimens. | Reference |
| BECN1 | Beclin 1, autophagy related | Adaptor Protein | BECN1 is implicated as a haploinsufficient tumour suppressor in prostate cancer; located on chromosome 17q21 that is commonly deleted in breast, ovarian, and prostate cancer. | Reference |
| TGFBR2 | Transforming growth factor, beta receptor II | Receptor Serine/threonine Kinase | It functions as a tumor suppressor in early tumorigenesis; it follows loss of expression, epigenetic silencing, mutation and down regulation during prostate tumorigenesis. | Reference |
| TGFBR2 | Transforming growth factor, beta receptor II | Receptor Serine/threonine Kinase | Overexpression of TGFBR2 LNCaP prostate cancer cells induces prostate tumorigenic suppression by caspase dependent apoptosis | Reference |
| TGFBR2 | Transforming growth factor, beta receptor II | Receptor Serine/threonine Kinase | Although TGF-beta inhibits the proliferation of normal prostate cells and functions as a tumor suppressor in early tumorigenesis, it acts as a tumor promoter in later stages of tumor progression | Reference |
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase | BMP-9 is a putative tumor suppressor in prostate cancer and and in thses functional context BMPR2 is required for its function | Reference |
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase | BMP-9 is a putative tumor suppressor in prostate cancer and BMPR2 is required for its function | Reference |
| EPHB2 | EPH receptor B2 | Receptor Tyrosine Kinase | EPHB2 is implicated as a prostate cancer tumour suppressor gene with somatic inactivating mutations occurring in ?10% of sporadic prostatic tumours. | Reference |
| PHB | Prohibitin | Adaptor Protein | PHB acts as a tumour suppressor and AR co repressor in prostate cancer; It is targeted by miR-27a, which is regulated by AR. | Reference |
| PHB | Prohibitin | Adaptor Protein | PHB mediates tumour suppressive effects in prostate cancer and is involved in maintaining a balance between cell survival and apoptosis | Reference |
| NGFR | Nerve growth factor receptor | Cell Surface Receptor | NGFR(p75NTR) tumour suppressor is lost during prostate cancer progression and is involved in regulation of apoptosis via intrinsic mitochondrial pathway. | Reference |
| ST7 | Suppression of tumorigenicity 7 | Cell Cycle Control Protein | ST7 located on chromosome 7q31.1 functions as a tumour suppressor in prostate cancer by mediating modification of tumour microenvironments. | Reference |
| CDKN1B | Cyclin-dependent kinase inhibitor 1B (p27, Kip1) | Cell Cycle Control Protein | CDKN1B (p27) located on chromosome 16q, functions as a tumour suppressor in prostate cancer due to allelic loss and LOH. | Reference |
| CDKN1A | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) | Cell Cycle Control Protein | CDKN1A (p21) acts as a tumour suppressor during prostate tumorigenesis because of promoter hypermethylation. | Reference |
| CEACAM1 | Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | Adhesion Molecule | CEACAM1 play a tumor suppressive role in prostate cancer due to its ability to inhibit angiogenesis. | Reference |
| FYN | FYN oncogene related to SRC, FGR, YES | Tyrosine Kinase | FYN functions as a prostate cancer tumour suppressor in the altered biochemical landscape of neoplastic transformation. | Reference |
| FYN | FYN oncogene related to SRC, FGR, YES | Tyrosine Kinase | FYN located at chromosome 6q21 play a tumour suppressive role during prostate cancer progression; suffers from chromosomal deletion & promoter hypermethylation.. | Reference |
| NGFR | Nerve growth factor receptor | Cell Surface Receptor | NGFR [p75(NTR)], a tumour suppressor which is lost during the course of prostate tumorigenesis, plays a significant role in regulation of prostate cancer cell cycle. | Reference |
| FOXO1 | Forkhead box O1 | Transcription Factor | FOXO1A, which is downregulated in human prostate cancer, plays an important tumour suppressive role through inhibition of androgen receptor signaling and suppression of prostate cancer cell proliferation. | Reference |
| MED1 | Mediator complex subunit 1 | Transcription Regulatory Protein | TGFBR3 functions as a tumour suppressor gene in human prostate cancer; Its loss of expression is mediated by LOH and epigenetic silencing. | Reference |
| cPAcP | Acid phosphatase, prostate | Acid Phosphatase | cPAcP functions as a negative regulator of cell proliferation and a tumour suppressor in prostate cancer. | Reference |
| ARA70 | Nuclear receptor coactivator 4 | Transcription Regulatory Protein | ARA70, an androgen receptor coactivator functions as a tumour suppressor gene in human prostate cancer and is associated with prostate cancer cell growth and invasion. | Reference |
| IQGAP2 | IQ motif containing GTPase activating protein 2 | GTPase activating protein | IQGAP2, functions as a tumour suppressor in human prostate cancer through regulation of E-cadherin. | Reference |
| ID4 | Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | Transcription Regulatory Protein | ID4, a member of the Id gene family, functions as an important tumour suppressor in human prostate cancer through influencing cell proliferation. | Reference |
| NKX3-1 | NK3 homeobox 1 | Transcription Factor | NKX3.1(NKX3-1), an androgen inducible tumour suppressor which is inactivated during prostate cancer progression, plays an important role in the activation of TMPRSS2-ERG fusions. | Reference |
| ALDH1A2 | Aldehyde dehydrogenase 1 family member A2 | Enzyme | ALDH1A2, encodes an enzyme responsible for synthesis of retinoic acid, functions as a potential tumour suppressor in human prostate cancer. | Reference |
| TGFBR3 | Transforming growth factor, beta receptor III | Cell Surface Receptor | TGFBR3, which is lost during prostate cancer progression, plays a very crucial tumour suppressive role through effecting on prostate cancer cell motility and invasion. | Reference |
| SERPINB5 | Serpin peptidase inhibitor, clade B (ovalbumin), member 5 | Protease inhibitor | The haploinsufficient tumour suppressor maspin (SERPINB5) plays a critical function in regulation of prostate epithelial cell proliferation. | Reference |
| TSC1 | Tuberous sclerosis 1 | Cytoskeletal associated protein | Tuberous sclerosis complex 1 (TSC1), a critical negative regulator of mTORC1 signaling, functions as a potential tumour suppressor in aged mouse. | Reference |
| CHD1 | Chromodomain helicase DNA binding protein 1 | DNA Binding Protein | Chromodomain helicase DNA-binding protein 1 (CHD1), functions as an essential tumour suppressor in prostate cancer through regulation of AR-responsive tumor suppressor genes. | Reference |
| CADM2 | Cell adhesion molecule 2 | Adhesion Molecule | CADM-2 plays a potential tumour suppressive role in the metastaatic progression of prostate cancer. | Reference |
| MT1H | Metallothionein 1H | Unclassified | MT1H, a metal binding protein plays a tumour suppressive role in human prostate cancer through activation of euchromatin histone methyltransferase 1 (EHMT1). | Reference |
| RFWD2 | Ring finger and WD repeat domain 2, E3 ubiquitin protein ligase | Ubiquitin proteasome system protein | Ubiquitin ligase COP1(RFWD2) functions as a tumour suppressor through influencing prostate cancer epithelial cell proliferation. | Reference |
| PAX6 | Paired box 6 | Transcription Factor | The tumour suppressive functions of PAX6 is mainly mediated by suppression of prostate cancer cell growth in an androgen receptor dependent manner. | Reference |
| CFD | Complement factor D (adipsin) | Enzyme | Adiponectin (CFD), a hormone secreted by adipose tissue plays an important tumour suppressive role in human prostate cancer associated epithelial mesenchymal transition (EMT) and is frequently inactivated by promoter methylation. | Reference |
| 15-LOX2 | Arachidonate 15-lipoxygenase, type B | Enzyme | 15-Lipoxygenase-2 (15-LOX2), a human-specific lipid-peroxidizing enzyme which plays a key role in the induction of cellular senescence program, functions as a critical tumour suppressor and is completely lost during prostate cancer progression. | Reference |