| Protein | Protein Name | Molecular Type | Evidence | Reference |
|---|
| E2F1 | E2F transcription factor 1 | Transcription Factor | E2F1 is involved in prostate cancer cell invasion and this activity is regulated by tristetraprolin (TTP). | Reference |
| MYC | V-myc avian myelocytomatosis viral oncogene homolog | Transcription Factor | c-MYC is associated with prostate cancer cell invasion through regulating ezrin protein expression in an androgen dependent way. | Reference |
| RUNX2 | Runt-related transcription factor 2 | Transcription Factor | RUNX2 play an important role in prostate cancer cell invasion through regulating matrix metaloproteinase 9 in bone metastatic prostate cancer cell. | Reference |
| LPXN | Leupaxin | Adaptor Protein | Plays a crucial role in prostate cancer cell invasion through transcriptional coactivation of AR in androgen independent prostate cancer cell line. | Reference |
| LPXN | Leupaxin | Adaptor Protein | Leupaxin(LPXN) is involved in prostate cancer invasion in TRAMP mice (transgenic adenocarcinoma of mouse prostate) model via downregulation of cell-cell adhesion protein p120catenin (p120CTN). | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | STAT3 is involved in TGFbeta1 mediated prostate cancer invasion. | Reference |
| SMAD3 | SMAD family member 3 | Transcription Regulatory Protein | Mediates prostate cancer bone metastasis through activin A-AR-SMAD3 signaling and cell invasion in a TGFBR1-SMAD3-PI3K dependent signaling. | Reference |
| GNB2L1 | Guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 | Adaptor Protein | GNB2L1(RACK1) is associated with prostate cancer cell Cell Invasion in both in vito and in viovo | Reference |
| DVL2 | Dishevelled segment polarity protein 2 | Adaptor Protein | Silencing of DVL2 expression decrease cell proliferation, motility , Cell Invasion and Wnt-3a, AR, MMP-2, MMP-9 expression in LNCaP prostate cancer cell | Reference |
| WASF1 | WAS protein family, member 1 | Adaptor Protein | miR-203 is a tumor suppressor and often downregulated in Prostate cancer, targets WASF1 mRNA and involved in Prostate cancer cell Cell Invasion | Reference |
| PARD3 | Par-3 family cell polarity regulator | Adaptor Protein | Influences prostate cancer cell invasion via asymmetric cell division and maintenance of cell polarity. | Reference |
| FADD | Fas (TNFRSF6)-associated via death domain | Adaptor Protein | Influences prostate cancer cell invasion through modulation of human telomerase reverse transcriptase expression. | Reference |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | Adaptor Protein | CRK is involved in prostate cancer cell invasion through complex formation with BCAR1 in highly invasive prostate cancer cell line PC-3, PC-3M. | Reference |
| TGFBR2 | Transforming growth factor, beta receptor II | Receptor Serine/threonine Kinase | During endothelial & perineural invasion TGF beta mediated enhanced secretion of CAV1 into the tumor microenvironment causes marked inhibition of prostate cancer apoptosis | Reference |
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase | It is involved in the regulation of endoglin mediated suppression of prostate cancer cell invasion. | Reference |
| AXL | AXL receptor tyrosine kinase | Receptor Tyrosine Kinase | AXL and its receptor GAS6 are involved in prostate cancer cell invasion in PC3 and DU145 prostate cancer cells. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | EGFR plays an important role in prostate cancer cell invasion as microRNA targeting EGFR suppressed cell invasion in androgen insensitive cell line PC3 and DU145. | Reference |
| NTRK1 | Neurotrophic tyrosine kinase, receptor, type 1 | Receptor Tyrosine Kinase | NTRK1 is involved in NGF and BDNF induced protate cancer cell invasion in PC-3 and DU145 prostate cancer cell lines. | Reference |
| MET | Met proto-oncogene | Receptor Tyrosine Kinase | c-MET is associated with sttromal invasion of prostate cancer. | Reference |
| ERBB2 | V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | Receptor Tyrosine Kinase | ERBB2 is involved in prostate cancer cell invasion through ERBB2-P3K-Matripase signaling pathway. | Reference |
| IFNAR1 | Interferon (alpha, beta and omega) receptor 1 | Cytokine Receptor | IFNAR1 is asociated with prostate cancer tumour Cell Invasion | Reference |
| IFNAR1 | Interferon (alpha, beta and omega) receptor 1 | Cytokine Receptor | IFNAR1 is asociated with prostate cancer tumour invasion | Reference |
| CXCR4 | Chemokine (C-X-C motif) receptor 4 | G protein Coupled Receptor | It plays a role in SLUG mediated cell invasion in androgen independent prostate cancer cell line. | Reference |
| NGFR | Nerve growth factor receptor | Cell Surface Receptor | NGFR(p75NTR) re-expression in stromal smooth muscle cells is related to the prostate cancer tumour cell invasion. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Mediates prostate cancer cell invasion by endothelial cells through IL-6-AR-TGFbeta-MMP9 signaling. | Reference |
| VAV3 | Vav 3 guanine nucleotide exchange factor | Guanine Nucleotide Exchange Factor | VAV3 is associated with prostate cancer cell invasion through ephrinA1-EphA2-Vav3-Rac1 signaling axis. | Reference |
| GOLM1 | Golgi membrane protein 1 | Transport/Cargo Protein | Golgi membrane protein 1 (GOLM1) is involved in prostate cancer cell invasion as inhibition of GOLM1 results in significant suppression of prostate cancer cell invasion. | Reference |
| CDKN1B | Cyclin-dependent kinase inhibitor 1B (p27, Kip1) | Cell Cycle Control Protein | CDKN1B(p27) is associated with prostate cancer cell invasion as downregulation of p27(Kip1) by XMRV infection results in enhancement of cell invasion. | Reference |
| FRS2 | Fibroblast growth factor receptor substrate 2 | Adaptor Protein | FRS2 is involved in prostate cancer cell invasion in a FGF-FGFR dependent signaling in DU145 cells. | Reference |
| ITGB4 | Integrin, beta 4 | Adhesion Molecule | (ITGB4)beta4 integrin enhance human prostate cancer cell invasion by amplifying receptor tyrosine kinase mediated signaling. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Beta catenine(CTNNB1) is associated invasion of prostate cancer cells. | Reference |
| MAPK14 | Mitogen-activated protein kinase 14 | Serine/Threonine Kinase | MAPK14(p38 alpha) along with ERK2 play an important role in the regulation of prostate cancer cancer cell invasion in response of LPA stimulation. | Reference |
| PRKCA | Protein kinase C, alpha | Serine/Threonine Kinase | Protein kinase C alpha (PKCA) is associated with prostate cancer cell invasion in an androgen responsive way. | Reference |
| MAPK3 | Mitogen-activated protein kinase 3 | Serine/Threonine Kinase | MAPK3(ERK1) activation is an important step in CXCL13-mediated prostate cancer cell invasion. | Reference |
| MAPK3 | Mitogen-activated protein kinase 3 | Serine/Threonine Kinase | MAPK3(ERK1) phosphorylation in response of human chorionic gonadotropin beta (hCGbeta) is associated with prostate cancer cell invasion. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | AKT1 is associated with prostate cancer cell invasion through the aberrant activation of PI3K-Akt pathway. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | AKT1 is involved in prostate cancer cell invasion in an integrin alpha(v)beta(3) dependent manner. | Reference |
| FRS3 | Fibroblast growth factor receptor substrate 3 | Adaptor Protein | FRS3 is involved in prostate cancer cell invasion in a FGF-FGFR dependent signaling in DU145 cells. | Reference |
| PIM2 | Pim-2 oncogene | Serine/Threonine Kinase | PIM2 is involved in the perineural invasion during prostate cancer progression. | Reference |
| TYK2 | Tyrosine kinase 2 | Tyrosine Kinase | TYK2 is involved in the prostate cancer cell invasion. | Reference |
| PXN | Paxillin | Cytoskeletal Associated Protein | Paxillin(PXN) is involved in the prostate cancer cell invasion through FAK/src/paxillin/Rac/JNK signaling resulting in the activation of MMP-2 and MMP-9 in prostate cancer LNCaP cell line. | Reference |
| WASF3 | WAS protein family, member 3 | Cytoskeletal Associated Protein | WASF3(WAVE3) is involved in the regulation of invasiveness in the prostate cancer cell line PC-3 and DU-145. | Reference |
| BCAR1 | Breast cancer anti-estrogen resistance 1 | Adaptor Protein | Regulates prostate cancer cell invasion through CRK-BCAR1 complex formation | Reference |
| RUNX2 | Runt-related transcription factor 2 | Transcription Factor | It's a osteogenic transcription factor and regulates cell invasion in androgen independent prostate cancer cell line. | Reference |
| SMAD3 | SMAD family member 3 | Transcription Regulatory Protein | It is involved in prostate cancer cell invasion in androgen independent prostate cancer cell line. | Reference |
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase | Mediates osteoblastic metastasis in prostate cancer ; regulates prostate cancer cell invasion. | Reference |
| FOXO1 | Forkhead box O1 | Transcription Factor | Downregulation of FOXO1 expression in human prostate cancer through MiR-182, plays a role in enhancement of prostate cancer cell invasion. | Reference |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 | Extracellular Matrix Protein | EFEMP1 inactivation through promoter methylation, plays a role in human prostate cancer associated cell invasion. | Reference |
| ACSL4 | Acyl-CoA synthetase long-chain family member 4 | Enzyme | Long-chain fatty acyl-CoA synthetase 4 (ACSL4), which is upregulated in human prostate cancer, is involved in prostate cancer cell invasion. | Reference |
| PIWIL2 | Piwi-like RNA-mediated gene silencing 2 | Transcription Regulatory Protein | Piwi-like RNA-mediated gene silencing 2 (Piwil2), an oncogene which is upregulated in human prostate cancer, plays a significant role in prostate cancer cell invasion through regulation of MMP9 expression. | Reference |
| ZAP70 | Zeta chain of T cell receptor associated protein kinase 70kDa | Tyrosine Kinase | Zeta-associated protein 70 (ZAP70) plays a role in human prostate cancer cell invasion as its regulator MiR-631 is downregulated during prostate cancer progression. | Reference |
| FRA-1 | FOS-like antigen 1 | Transcription Factor | FRA-1 plays a role in human prostate cancer associated cell invasion as its regulator MiR-195 (a tumour suppressor) is frequently down regulated during prostate cancer development. | Reference |
| PTTG1 | Pituitary tumor-transforming 1 | Transcription Regulatory Protein | Pituitary tumor-transforming gene 1 (PTTG1) is involved in the regulation prostate cancer cell invasion through matrix metalloproteinase 13 (MMP13). | Reference |
| UBE2T | Ubiquitin conjugating enzyme E2T | Ubiquitin proteasome system protein | Ubiquitin-conjugating enzyme E2T (UBE2T), which is highly expressed in human prostate cancer, plays a role in human prostate cancer associated cell invasion. | Reference |
| LCN2 | Lipocalin 2 | Transport/Cargo Protein | Lipocalin 2 (LCN2), a member of the lipocalin family, is highly expressed in human prostate cancer and plays a role in enhancement of prostate cancer associated cell invasion. | Reference |
| YAP1 | Yes associated protein 1 | Transcription Regulatory Protein | Yes-associated protein (YAP), a crucial effector of the hippo tumor suppressor pathway, plays a role in the regulation of human prostate cancer associated cell invasion and there by promotes metastasis.. | Reference |
| AQP3 | Aquaporin 3 | Water Channel | Aquaporin 3 (AQP3) critically mediated human prostate cancer associated cell invasion through upregulation of MMP3 expression via ERK1/2 activation. | Reference |
| P2X7 | Purinergic receptor P2X, ligand gated ion channel, 7 | Extracellular ligand gated channel | ATP-gated P2X7 plays a significant role in promotion of human prostate cancer cell invasion through activation of PI3K/AKT and ERK1/2 signaling pathways. | Reference |
| RAP1A | RAP1A, member of RAS oncogene family | GTPase | RAP1A, which is upregulated in human prostate cancer, plays a role in prostate cancer cell invasion as its critical negative regulator MiR-203 is significantly downregulated in human prostate cancer. | Reference |
| SPAG9 | Sperm associated antigen 9 | Integral Membrane Protein | Sperm-associated antigen 9 (SPAG9), which is highly expressed in human prostate cancer, plays a role in promotion of prostate cancer associated cell invasion and there by facilitates metastatic progression. | Reference |