| Protein | Protein Name | Molecular Type | Evidence | Reference |
|---|
| MYC | V-myc avian myelocytomatosis viral oncogene homolog | Transcription Factor | c-MYC is involved in prostate cancer epithelial mesenchymal transition upon phosphorylation by ERK2. | Reference |
| TP53 | Tumor protein p53 | Transcription Factor | TP53 loss in prostate epithelial cell results in epithelial mesenchymal transition in prostate cancer. | Reference |
| SMAD4 | SMAD family member 4 | Transcription Factor | SMAD4 is involved in prostate cancer epithelial mesenchymal transition through TGFbeta/BMP-SMAD4 signaling pathway. | Reference |
| WT1 | Wilms tumor 1 | Transcription Factor | Wilm's tumour gene (WT1) play an important role in the epithelial mesenchymal transition in PC-3 prostate cancer cell. | Reference |
| TGFBR2 | Transforming growth factor, beta receptor II | Receptor Serine/threonine Kinase | Increased production of TGF beta causes epithelial mesenchymal transition | Reference |
| TGFBR2 | Transforming growth factor, beta receptor II | Receptor Serine/threonine Kinase | Increased production of TGF beta causes epithelial mesenchymal transition | Reference |
| AXL | AXL receptor tyrosine kinase | Receptor Tyrosine Kinase | AXL regulates epithelial mesenchymal (EMT) marker expression in prostate cancer, supported by experiments on PC3 and DU145 prostate cancer cells. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | EGFR is involved in prostate cancer epithelial mesenchymal transition in a LIV-1 induced and ERK mediated signaling. | Reference |
| FGFR1 | Fibroblast growth factor receptor 1 | Receptor Tyrosine Kinase | FGFR1 activation results in epithelial mesenchymal transition in the epithelial compartment during prostate cancer progression. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Androgen receptor mediated signaling is responsible for epithelial mesenchymal transition in prostate epithelial cells | Reference |
| AR | Androgen receptor | Nuclear Receptor | Androgen receptor mediated signaling is responsible for epithelial mesenchymal transition in prostate epithelial cells | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Beta catenine is associated with epithelial mesenchymal transition in prostate cancer development mediated by SOX2. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Beta catenine is involved in the epithelial mesenchymal transition of prostate cancer stem cell through HIF-1alpha/beta-catenin-dependent signaling pathway. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | SPINK1, which is overexpressed in prostate cancer promotes EMT through EGFR signaling. | Reference |
| AR | Androgen receptor | Nuclear Receptor | It promotes prostate cancer metastasis by regulating EMT. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Androgen deprivation therapy mediates prostate cancer EMT through a feed back loop involving AR and Zeb1 transcription factor. | Reference |
| TP53 | Tumor protein p53 | Transcription Factor | Loss of TP53 enhances EMT and stemness of prostate cancer cells through partially through repressing miR-145. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | EPLIN downregulation in metastatic prostate cancer results in the activation of beta catenine mediated pro-EMT gene expression. | Reference |
| JAK2 | Janus kinase 2 | Tyrosine Kinase | JAK2-STAT5a/b mediated signaling plays a role in prostate cancer epithelial mesenchymal transition. | Reference |
| DAB2IP | DAB2 interacting protein | Ras GTPase-activating protein | Loss of DAB2IP is associated with prostate cancer epithelial mesenchymal transition , supported by experiments on human prostate xenograft-mouse model. | Reference |
| PML | Promyelocytic leukemia | Transcription Regulatory Protein | Cytoplasmic promyelocytic leukaemia (cPML) plays a very critical role in the induction of prostate cancer associated epithelial mesenchymal transition (EMT) through activation of TGF beta mediated signaling. | Reference |
| TWIST1 | Twist family bHLH transcription factor 1 | Transcription Factor | TWIST1 transcription factor plays a vital role in human prostate cancer associated epithelial mesenchymal transition through interaction with androgen receptor(AR) and there by promotes castration resistance. | Reference |
| POSTN | Periostin, osteoblast specific factor | Adhesion Molecule | Periostin(POSTN), which is upregulated in human prostate cancer plays a role in prostate cancer related epithelial mesenchymal transition (EMT) in a TGF beta dependent manner. | Reference |
| CFD | Complement factor D (adipsin) | Enzyme | Adiponectin (CFD), a hormone secreted by adipose tissue and frequently inactivated in human prostate cancer, plays a tumour suppressive role in the context of prostate cancer associated epithelial mesenchymal transition. | Reference |
| PAK1 | p21 protein (Cdc42/Rac)-activated kinase 1 | Serine/Threonine Kinase | P21-activated kinase1 (PAK1) plays a role in prostate cancer epithelial mesenchymal transition through a TGF-Beta deependent signaling pathway. | Reference |
| PARP1 | Poly(ADP-ribose) polymerase 1 | Enzyme | Poly (ADP-ribose) polymerase (PARP) is involved in the promotion of prostate cancer associated epithelial mesenchymal transition (EMT) ina TGF beta responsive manner. | Reference |
| FGF19 | Fibroblast growth factor 19 | Growth Factor | FGF19, highly expressed in human prostate cancer, plays a role in prostate cancer associated epithelial mesenchymal transition (EMT). | Reference |
| PIWIL2 | Piwi-like RNA-mediated gene silencing 2 | Transcription Regulatory Protein | Piwi-like RNA-mediated gene silencing 2 (Piwil2), an oncogene which is upregulated in human prostate cancer, plays a significant role in modulation of prostate cancer associated epithelial mesenchymal transition (EMT) through regulation of MMP9 expression. | Reference |
| EPLIN | LIM domain and actin binding 1 | Cytoskeletal Protein | EPLIN, an actin associated molecule, plays a pivotal role in regulation of prostate cancer associated epithelial mesenchymal transition (EMT). | Reference |
| LCN2 | Lipocalin 2 | Transport/Cargo Protein | Lipocalin 2 (LCN2), a member of the lipocalin family, is highly expressed in human prostate cancer and is involved in the induction of prostate cancer associated epithelial mesenchymal transition (EMT) through regulation of SLUG expression via ERK pathway activation. | Reference |