| Protein | Protein Name | Molecular Type | Evidence | Reference |
|---|
| E2F1 | E2F transcription factor 1 | Transcription Factor | E2F1 is involved in prostate cancer cellmigration and this activity is regulated by tristetraprolin (TTP). | Reference |
| RUNX2 | Runt-related transcription factor 2 | Transcription Factor | RUNX2 is involved in prostate cancer cell migration as FOXO1 targets and inhibits RUNX2 and causes suppression of prostate cancer cell migration . | Reference |
| WT1 | Wilms tumor 1 | Transcription Factor | Wilm's tumour gene (WT1) is involved in prostate cancer cell migration as in PC-3 prostate cancer cell, silencing of WT1 results in suppression of cell migration. | Reference |
| LPXN | Leupaxin | Adaptor Protein | (LPXN) regulates prostate cancer cell migration through the complex formation with Pyk2, c-Src, and PTP-PEST in androgen independent prostate cancer cell line PC-3. | Reference |
| SRF | Serum response factor (c-fos serum response element-binding transcription factor) | Transcription Factor | Serum response factor(SRF) modulates prostate cancer cell migration in an androgen responsive way. | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | high density lipoprotein (HDL) and sphingosine-1-phosphate (S1P) activates STAT3 via ERK1/2 and promotes prostate cancer cell migration. | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | STAT3 is involved in IL-6 mediated cell migration in prostate cancer DU145 cells. | Reference |
| SMAD3 | SMAD family member 3 | Transcription Regulatory Protein | SMAD3 is associated with the prostate cancer cell invasion through TGFBR1-SMAD3-PI3-kinase signaling. | Reference |
| SMAD7 | SMAD family member 7 | Transcription Regulatory Protein | SMAD7 is involved in prostate cancer cell migration in a TGF beta dependent way. | Reference |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | GTPase | RAC1 is involved in prostate cancer cell migration through actin polymerization and filopedia formation | Reference |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | GTPase | TROP2 modulates RAC1 and enhance prostate cancer cell migration. | Reference |
| KRAS | Kirsten rat sarcoma viral oncogene homolog | GTPase | Promotes cell migration through EGFR/RAS/MAPK pathway in prostate cancer tissues and androgen independent prostate cancer cell lines. | Reference |
| PDE4D | Phosphodiesterase 4D, cAMP-specific | Enzyme Phosphodiesterase | PDE4D is involved in prostate cancer cell migration as knock down of this gene reduced the cell migration rate of prostate cancer cell in vivo. | Reference |
| GNB2L1 | Guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 | Adaptor Protein | GNB2L1(RACK1) is associated with prostate cancer cell migration in both in vito and in viovo | Reference |
| YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | Adaptor Protein | 14-3-3zeta enhances prostate cancer cell-matrix interactions, motility and transendothelial migration in vitro via activation of Rac1-GTPase | Reference |
| DVL2 | Dishevelled segment polarity protein 2 | Adaptor Protein | Involves in androgen independent prostate cancer cell migration and its activity is regulated by miR-221 | Reference |
| FHL2 | Four and a half LIM domains 2 | Adaptor Protein | Promotes cell migration in androgen independent PC-3 prostate cancer cell line and its activity is regulated by Ets-1; an androgen co regulator | Reference |
| BCAR1 | Breast cancer anti-estrogen resistance 1 | Adaptor Protein | FAK-Src-BCAR1-Crk pathway plays critical roles in cell migration of metastatic prostate cancer cell line Du145 | Reference |
| WASF1 | WAS protein family, member 1 | Adaptor Protein | Promotes cell migration in DU145 and PC3 prostate cancer cell line and its mRNA is a direct target of tumour suppressor miR-203 | Reference |
| PARD3 | Par-3 family cell polarity regulator | Adaptor Protein | Mutational inactivation of PARD3 gene is involved in assymmetric cell division and results in cell migratory aspects of oncogenesis | Reference |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | Adaptor Protein | CRK is involved in prostate cancer cell migration through complex formation with BCAR1 in highly invasive prostate cancer cell line PC-3, PC-3M. | Reference |
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase | BMP9 causes in vitro inhibition of cell migration in prostate cancer and BMPR2 is required for its function | Reference |
| IGF1R | Insulin-like growth factor 1 receptor | Receptor Tyrosine Kinase | IGF1R is involved in androgen independent prostate cancer cell migration through alphavbeta3 integrin and PI3-K/Akt signaling pathway. | Reference |
| AXL | AXL receptor tyrosine kinase | Receptor Tyrosine Kinase | AXL and its receptor GAS6 are involved in prostate cancer cell migration in PC3 and DU145 prostate cancer cells. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | EGFR is involved in prostate cancer cell migration through AKT dependent way. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | EGFR plays an important role in prostate cancer cell migration as microRNA targeting EGFR suppressed cell migration in androgen insensitive cell line PC3 and DU145. | Reference |
| NTRK1 | Neurotrophic tyrosine kinase, receptor, type 1 | Receptor Tyrosine Kinase | NTRK1 is associated with NGF and BDNF induced cell migration in different prostate cancer cell lines. | Reference |
| FGFR1 | Fibroblast growth factor receptor 1 | Receptor Tyrosine Kinase | FGF2 & its receptor FGFR1 is involved in prostate cancer cell migration. | Reference |
| MET | Met proto-oncogene | Receptor Tyrosine Kinase | c-MET is involved in prostate cancer cell migration in DU-145 prostate cancer cells. | Reference |
| EPHA2 | EPH receptor A2 | Receptor Tyrosine Kinase | Arachidonic acid mediates prostate cancer epithelial cell migration in an EPHA2 dependent fashion. | Reference |
| CXCR4 | Chemokine (C-X-C motif) receptor 4 | G protein Coupled Receptor | SLUG and CXCL12 enhances prostate cancer cell migration through CXCR4. | Reference |
| NGFR | Nerve growth factor receptor | Cell Surface Receptor | NGFR(p75NTR) is involved in prostate cancer cell migration via NGFR(p75NTR)-P38mapk-nag1 pathway. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Androgen receptor play an important role in prostate cancer cell migration through activin A-Smad-AR axis. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Androgen receptor target gene TM4SF1 is overexpressed in human prostate cancer and is involved in prostate cancer cell migration | Reference |
| AR | Androgen receptor | Nuclear Receptor | AR/FlnA/integrin beta 1 complex is the key by which androgen activates signaling leading to prostate cancer cell migration | Reference |
| VAV3 | Vav 3 guanine nucleotide exchange factor | Guanine Nucleotide Exchange Factor | VAV3 is associated with prostate cancer cell migration through ephrinA1-EphA2-Vav3-Rac1 signaling axis. | Reference |
| FRS2 | Fibroblast growth factor receptor substrate 2 | Adaptor Protein | FRS2 is involved in prostate cancer cell migration in a FGF-FGFR dependent signaling in DU145 cells. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Beta catenine is involved in the migration of prostate cancer stem cell through HIF-1alpha/beta-catenin-dependent signaling pathway. | Reference |
| APC | Adenomatous polyposis coli | Adhesion Molecule | APC and SMAD7 play an important role in prostate cancer cell migration by establishing a link between TGFBR1 and microtubule system. | Reference |
| MAPK14 | Mitogen-activated protein kinase 14 | Serine/Threonine Kinase | MAPK14(p38 alpha) is involved in prostate cancer cell migration along with ERK2 in a LPA induced manner in the PC-3 prostate cancer cell line. | Reference |
| MAPK3 | Mitogen-activated protein kinase 3 | Serine/Threonine Kinase | MAPK3(ERK1) phosphorylation in response of human chorionic gonadotropin beta (hCGbeta) is associated with prostate cancer cell migration. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | AKT1 is involved in prostate cancer trans endothelial migration in an integrin alpha(v)beta(3) dependent manner. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | PI3K/AKT1 pathway play an important role in prostate cancer cell migration through HGF/SF responsive way | Reference |
| FRS3 | Fibroblast growth factor receptor substrate 3 | Adaptor Protein | FRS3 is involved in prostate cancer cell migration in a FGF-FGFR dependent signaling in DU145 cells. | Reference |
| SRC | V-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog | Tyrosine Kinase | Src is involved in prostate cancer cell migration in a bradykinin dependent ways. | Reference |
| SRC | V-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog | Tyrosine Kinase | SRC is involved in prostate cancer cell migration in CCL2 and CCCR2 responsive ways mediated by PKCdelta, c-Src, and AP-1. | Reference |
| BCAR1 | Breast cancer anti-estrogen resistance 1 | Adaptor Protein | Functions as a cell migration switch in in highly invasive prostate cancer PC-3M and PC-3 cell lines. | Reference |
| FOXO1 | Forkhead box O1 | Transcription Factor | Downregulation of FOXO1 expression in human prostate cancer through MiR-182, plays a role in enhancement of prostate cancer cell migration. | Reference |
| ZAP70 | Zeta chain of T cell receptor associated protein kinase 70kDa | Tyrosine Kinase | Zeta-associated protein 70 (ZAP70) plays a role in human prostate cancer cell migration as its regulator MiR-631 is downregulated during prostate cancer progression. | Reference |
| CDH11 | Cadherin 11, type 2, OB-cadherin (osteoblast) | Cell Junction Protein | Cadherin-11 (CDH11), a cell adhesion molecule which is internalized in human prostate cancer cell through clathrin dependent ways, plays a role in the regulation of prostate cancer cell migration. | Reference |
| FRA-1 | FOS-like antigen 1 | Transcription Factor | FRA-1 plays a role in human prostate cancer associated cell migration as its regulator MiR-195 (a tumour suppressor) is frequently down regulated during prostate cancer development. | Reference |
| TCTN1 | Tectonic family member 1 | Unclassified | TCTN1, which is involved in human embryonic development, plays a role in human prostate cancer cell migration through regulation of cytoskeletal remodelling. | Reference |
| SNAIL | Snail family zinc finger 1 | Transcription Regulatory Protein | SNAIL, a zinc-finger transcription factor drives human prostate cancer cell migration through activation of PI3K/AKT/RAC1 signaling axis. | Reference |
| EIF3D | Eukaryotic translation initiation factor 3 subunit D | Translation Regulatory Protein | EIF3 is highly expressed in human prostate cancer, plays a role in prostate cancer cell migration. | Reference |