| Protein | Protein Name | Molecular Type | Evidence | Reference |
|---|
| STAT5B | Signal transducer and activator of transcription 5B | Transcription Factor | STAT5B is associated with prostate cancer cell survival. | Reference |
| E2F1 | E2F transcription factor 1 | Transcription Factor | E2F1 is involved in prostate cancer cell survival through NF-kappaB dependent induction of EGR1 transcription factor. | Reference |
| FOXO1 | Forkhead box O1 | Transcription Factor | Its inactivation via CDK1 mediated phosphorylation enhances cell survival in androgen dependent prostate cancer cell line. | Reference |
| COMMD1 | Copper metabolism (Murr1) domain containing 1 | Unclassified | Secretory clusterin (sCLU) degrades COMMD1 and promotes prostate cancer cell survival through activation of canonical NF-kappaB pathway. | Reference |
| BCL2 | B-cell CLL/lymphoma 2 | Adaptor Protein | Antisense mediated downregulation of BCL2 inhibits prostate cancer cell survival. | Reference |
| BCL2 | B-cell CLL/lymphoma 2 | Adaptor Protein | BCL2 is involved in prostate cancer cell survival by the regulation of Ceramide and Arachidonate signaling pathway. | Reference |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | GTPase | RAC1 is associated with prostate cancer cell survival through AKT mediated pathway. | Reference |
| SOCS3 | Suppressor of cytokine signaling 3 | Adaptor Protein | SOCS3 plays an important role in castration resistant prostate cancer cell survival. | Reference |
| YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | Adaptor Protein | 14-3-3 zeta (YWHAZ) interacts with AR and promotes prostate cancer cell survival in an androgen responsive way | Reference |
| CFLAR | CASP8 and FADD-like apoptosis regulator | Adaptor Protein | Androgen recptor regulates CFLAR and effects prostate cancer cell survival | Reference |
| BIRC6 | Baculoviral IAP repeat containing 6 | Adaptor Protein | Play a role in prostate cancer cell survival , treatment resistance & castration resistance in androgen dependent and independent prostate cancer cell lines. | Reference |
| BCL2L1 | BCL2-like 1 | Adaptor Protein | BCL2L1 is involved in prostate cancer cell survival through interaction with proapoptotic BAK | Reference |
| BCL2L1 | BCL2-like 1 | Adaptor Protein | BCL2L1 is involved in prostate tumour cell survival by AR induced Integrin alpha6beta1 mediated manner | Reference |
| FADD | Fas (TNFRSF6)-associated via death domain | Adaptor Protein | Strongly influences prostate cancer cell survival by modulating hTERT expression and telomerase activity in androgen independent prostate cancer cell line. | Reference |
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase | BMPR2 promotes prostate cancer cell survival | Reference |
| IGF1R | Insulin-like growth factor 1 receptor | Receptor Tyrosine Kinase | Mediates prostate cancer cell survival through Akt; involved in suppression of apoptosis; mediates prosurvival signaling by neuroendocrine derived peptides. | Reference |
| PDGFRB | Platelet-derived growth factor receptor, beta polypeptide | Receptor Tyrosine Kinase | PDGFRB-MCL1 mediated survival signaling play an important role in prostate cancer cell survival. | Reference |
| AXL | AXL receptor tyrosine kinase | Receptor Tyrosine Kinase | AXL is involved in prostate cancer cell survival as suppression of AXL by small interfering RNA suppress prostate cancer cell survival. | Reference |
| PDGFRA | Platelet-derived growth factor receptor, alpha polypeptide | Receptor Tyrosine Kinase | PDGFRA is implicated in prostate cancer cell survival. | Reference |
| PRLR | Prolactin receptor | Receptor Tyrosine Kinase | PRLR mediated signaling provides critical survival advantages for prostate cancer | Reference |
| GHR | Growth hormone receptor | Cell Surface Receptor | Autocrine growth hormone is involved in prostate cancer cell survival through alteration of GHR trafficking in androgen-dependent LNCaP cells. | Reference |
| NGFR | Nerve growth factor receptor | Cell Surface Receptor | NGFR(p75NTR) and its ligand NGFR is involved in pro survival signaling in prostate cancer. | Reference |
| AR | Androgen receptor | Nuclear Receptor | AR transcriptionally activate 14-3-3zeta and through its action enhances prostate cancer cell survial & proliferation | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Play a role in osteopontin mediated prostate cancer cell survival in androgen dependent & independent prostate cancer cell line. | Reference |
| MAPK3 | Mitogen-activated protein kinase 3 | Serine/Threonine Kinase | MAPK3(ERK1) is associated with prostate cancer cell survival through PKCepsilon/PKD3 pathway. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | AKT1 is involved in prostate cancer cell survival in a cholesterol responsive way. | Reference |
| PRKCE | Protein kinase C, epsilon | Serine/Threonine Kinase | PRKCE is associate with prostate cancer cell survival by interacting with BAX in LNCaP cells. | Reference |
| PRKCD | Protein kinase C, delta | Serine/Threonine Kinase | PRKCD is involved in prostate cancer cell survival in an Androgen receptor(AR) dependent manner in both hormone sensitive and castration resistant prostate cancer. | Reference |
| PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta | Lipid Kinase | Involved in cell survival through AKT activation in both androgen dependent & independent prostate cancer cell line. | Reference |
| PRKCE | Protein kinase C, epsilon | Serine/Threonine Kinase | It is involved in prostate cancer cell survival through integrin mediated Akt/PKB activation. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Disruption of reciprocal balance between the beta-cat/Tcf and the beta-cat/AR pathways results in prostate cancer cell survival. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | It mediates prostate cancer cell survival in response of IGF1R. | Reference |
| PDGFRA | Platelet-derived growth factor receptor, alpha polypeptide | Receptor Tyrosine Kinase | Mediates prostate cancer cell survival through Akt/PKB manner in bone metastatic prostate cancer. | Reference |
| IGF1R | Insulin-like growth factor 1 receptor | Receptor Tyrosine Kinase | Mediates prostate cancer prosurvival signaling by neuroendocrine derived peptides. | Reference |
| PIAS1 | Protein inhibitor of activated STAT, 1 | Cell Cycle Control Protein | PIAS1, which is overexpressed in human prostate tumour plays a role in prostate cancer cell survival. | Reference |
| BTK | Bruton agammaglobulinemia tyrosine kinase | Tyrosine Kinase | Bruton's tyrosine kinase (BTK), a non receptor tyrosine kinase plays a role in human prostate cancer cell survival. | Reference |
| GSTP1 | Glutathione S-transferase pi 1 | Enzyme | Glutathione S-transferase pi 1 (GSTP1), which is epigenetically inactivated during transformation from normal prostatic epithelium to adenocarcinoma of the prostate, plays a role in human ovarian cancer cell survival. | Reference |
| JMJD1A | Lysine (K)-specific demethylase 3A | Unclassified | Histone demethylase JMJD1A plays a role in human prostate cancer cell survival through regulating c-MYC expression at both transcriptional and post-transcriptional level. | Reference |
| DAXX | Death-domain associated protein | Adaptor protein | DAXX, an adaptor protein plays a very important role in prostate cancer cell survival through suppression of autophagy. | Reference |
| HAMP | Hepcidin antimicrobial peptide | Unclassified | Hepcidin (HAMP), a central iron regulator which is highly expressed in human prostate cancer cell, plays a role in prostate cancer cell survival. | Reference |
| TLR4 | Toll-like receptor 4 | Cell Surface Receptor | Toll-like receptor-4 (TLR4) is involved in human prostate cancer cell survival. | Reference |
| ARR2 | Arrestin, beta 2 | Adaptor protein | Beta arrestin2 (ARR2), a ubiquitous scaffolding/adaptor protein, plays a role in castration resistant prostate cancer (CRPC) associated cell survival through downregulation of FOXO1 activity and expression. | Reference |