Human Prostrate Cancer Hallmarks Map

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Prostrate Cancer Chemoresistance

Intrinsic components of Prostrate Cancer Chemoresistance

ProteinProtein NameMolecular TypeEvidenceReference
MYCV-myc avian myelocytomatosis viral oncogene homologTranscription Factorc-Myc mediated signaling play an important role in docitaxel resistance in prostate cancer.Reference
MYCV-myc avian myelocytomatosis viral oncogene homologTranscription FactorHexosamine biosynthetic pathway (HBP) through O-linked beta-N-acetylglucosamine transferase (OGT) regulates the stability of c-MYC in prostate cancer.Reference
BCL2L2BCL2-like 2Adaptor ProteinMediates resistance to chemotherapy induced apoptosis in androgen dependent & independent prostate cancer cell line; it is targeted by miR-205 and miR-31.Reference
BIRC6Baculoviral IAP repeat containing 6Adaptor ProteinBIRC6 is involved in Therapeutic resistance and contributes towards prostate cancer progressionReference
ARAndrogen receptorNuclear ReceptorIt is critically involved in multidrug resistance including docetaxel resistance in prostate cancer through crosstalking with Twist1/YB-1 signalling.Reference
PRKCAProtein kinase C, alphaSerine/Threonine KinaseIt plays a role in the development of cisplatin resistance through stabilization of BCL2 in both androgen dependent & independent prostate cancer cell line.Reference
BCL2B-cell CLL/lymphoma 2Adaptor ProteinIt is overexpressed in 70% of androgen independent prostate cancer: contributes to prostate cancer chemoresistance.Reference
ARAndrogen receptorNuclear ReceptorIt mediates enzalutamide resistance through NF-?B2/p52 signaling in androgen dependent prostate cancer cell line.Reference
PIAS1Protein inhibitor of activated STAT, 1Cell Cycle Control ProteinPIAS1, a cytokine signaling modulator and cell cycle regulator which is overexpressed in local and metastatic prostate cancer, plays a critical role in docetaxel resistance and docetaxel resistant cell survival in human prostate cancer.Reference
CXCR4Chemokine (C-X-C motif) receptor 4G protein Coupled ReceptorCXCL12/CXCR4 signaling axis is critically involved in the acquisition of docetaxel resistance in human prostate cancer cell through PAK4-dependent activation of LIMK1.Reference
EGFREpidermal growth factor receptorReceptor Tyrosine KinaseEpidermal growth factor receptor (EGFR), which is overexpressed in human prostate cancer, plays a role in the promotion of docetaxel resistance in castration resistant prostate cancer (CRPC) cell through AKT dependent expression of MDR1.Reference
DAB2IPDAB2 interacting proteinRas GTPase-activating proteinIts loss of expression contributes to docetaxel resistance in androgen dependent prostate cancer cell line.Reference
OPNOsteopontinAdhesion MoleculeOsteopontin (OPN), a phosphoprotein plays a role in mediating docetaxel resistance in PC3 prostate cancer cell through its splice variants.Reference
ABCB1ATP binding cassette subfamily B member 1Transport ProteinABCB1, a transporter plays a very important role in the acquisition of docetaxel resistance in human prostate cancer cell.Reference
PRKAR2AProtein kinase, cAMP-dependent, regulatory subunit type II alphaSerine/Threonine KinasePRKAR2A, a type II-alpha regulatory subunit of protein kinase A, modulates taxol resistance in human prostate cancer cell.Reference
ERGv-ets avian erythroblastosis virus E26 oncogene homologTranscription FactorERG, a product of the ETS gene rearrangement in prostate cancer, plays a very crucial role in cabazitaxel and docetaxel resistance in human prostate cancer.Reference
NR2C2Nuclear receptor subfamily 2 group C member 2Nuclear ReceptorTesticular nuclear receptor 4 (TR4) or NR2C2 plays a role in driving docetaxel resistance in castration resistant prostate cancer (CRPC).Reference
NOTCH1Notch 1Cell Surface ReceptorNOTCH1 mediated signaling plays an essential role in mediating chemoresistance in prostate cancer stem cell (are believed to be the origin of cancer recurrence following therapy intervention) through regulation of ABCC1 expression.Reference
PIM1Pim-1 proto-oncogene, serine/threonine kinaseSerine/Threonine KinasePIM1 kinase, a serine/threonine kinase that is overexpressed in human prostate cancer, is involved in the development of docetaxel resistance in castration resistant prostate cancer cell.Reference
ARRB1Arrestin, beta 1Adaptor ProteinIL6 plays a role in docetaxel resistance in castration resistant prostate cancer (CRPC).Reference