| Protein | Protein Name | Molecular Type | Evidence | Reference |
|---|
| MYC | V-myc avian myelocytomatosis viral oncogene homolog | Transcription Factor | c-Myc mediated signaling play an important role in docitaxel resistance in prostate cancer. | Reference |
| MYC | V-myc avian myelocytomatosis viral oncogene homolog | Transcription Factor | Hexosamine biosynthetic pathway (HBP) through O-linked beta-N-acetylglucosamine transferase (OGT) regulates the stability of c-MYC in prostate cancer. | Reference |
| BCL2L2 | BCL2-like 2 | Adaptor Protein | Mediates resistance to chemotherapy induced apoptosis in androgen dependent & independent prostate cancer cell line; it is targeted by miR-205 and miR-31. | Reference |
| BIRC6 | Baculoviral IAP repeat containing 6 | Adaptor Protein | BIRC6 is involved in Therapeutic resistance and contributes towards prostate cancer progression | Reference |
| AR | Androgen receptor | Nuclear Receptor | It is critically involved in multidrug resistance including docetaxel resistance in prostate cancer through crosstalking with Twist1/YB-1 signalling. | Reference |
| PRKCA | Protein kinase C, alpha | Serine/Threonine Kinase | It plays a role in the development of cisplatin resistance through stabilization of BCL2 in both androgen dependent & independent prostate cancer cell line. | Reference |
| BCL2 | B-cell CLL/lymphoma 2 | Adaptor Protein | It is overexpressed in 70% of androgen independent prostate cancer: contributes to prostate cancer chemoresistance. | Reference |
| AR | Androgen receptor | Nuclear Receptor | It mediates enzalutamide resistance through NF-?B2/p52 signaling in androgen dependent prostate cancer cell line. | Reference |
| PIAS1 | Protein inhibitor of activated STAT, 1 | Cell Cycle Control Protein | PIAS1, a cytokine signaling modulator and cell cycle regulator which is overexpressed in local and metastatic prostate cancer, plays a critical role in docetaxel resistance and docetaxel resistant cell survival in human prostate cancer. | Reference |
| CXCR4 | Chemokine (C-X-C motif) receptor 4 | G protein Coupled Receptor | CXCL12/CXCR4 signaling axis is critically involved in the acquisition of docetaxel resistance in human prostate cancer cell through PAK4-dependent activation of LIMK1. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | Epidermal growth factor receptor (EGFR), which is overexpressed in human prostate cancer, plays a role in the promotion of docetaxel resistance in castration resistant prostate cancer (CRPC) cell through AKT dependent expression of MDR1. | Reference |
| DAB2IP | DAB2 interacting protein | Ras GTPase-activating protein | Its loss of expression contributes to docetaxel resistance in androgen dependent prostate cancer cell line. | Reference |
| OPN | Osteopontin | Adhesion Molecule | Osteopontin (OPN), a phosphoprotein plays a role in mediating docetaxel resistance in PC3 prostate cancer cell through its splice variants. | Reference |
| ABCB1 | ATP binding cassette subfamily B member 1 | Transport Protein | ABCB1, a transporter plays a very important role in the acquisition of docetaxel resistance in human prostate cancer cell. | Reference |
| PRKAR2A | Protein kinase, cAMP-dependent, regulatory subunit type II alpha | Serine/Threonine Kinase | PRKAR2A, a type II-alpha regulatory subunit of protein kinase A, modulates taxol resistance in human prostate cancer cell. | Reference |
| ERG | v-ets avian erythroblastosis virus E26 oncogene homolog | Transcription Factor | ERG, a product of the ETS gene rearrangement in prostate cancer, plays a very crucial role in cabazitaxel and docetaxel resistance in human prostate cancer. | Reference |
| NR2C2 | Nuclear receptor subfamily 2 group C member 2 | Nuclear Receptor | Testicular nuclear receptor 4 (TR4) or NR2C2 plays a role in driving docetaxel resistance in castration resistant prostate cancer (CRPC). | Reference |
| NOTCH1 | Notch 1 | Cell Surface Receptor | NOTCH1 mediated signaling plays an essential role in mediating chemoresistance in prostate cancer stem cell (are believed to be the origin of cancer recurrence following therapy intervention) through regulation of ABCC1 expression. | Reference |
| PIM1 | Pim-1 proto-oncogene, serine/threonine kinase | Serine/Threonine Kinase | PIM1 kinase, a serine/threonine kinase that is overexpressed in human prostate cancer, is involved in the development of docetaxel resistance in castration resistant prostate cancer cell. | Reference |
| ARRB1 | Arrestin, beta 1 | Adaptor Protein | IL6 plays a role in docetaxel resistance in castration resistant prostate cancer (CRPC). | Reference |