| Protein | Protein Name | Molecular Type | Evidence | Reference |
|---|
| STAT5B | Signal transducer and activator of transcription 5B | Transcription Factor | Promotes cell growth in androgen dependent & independent prostate cancer cell line. | Reference |
| E2F1 | E2F transcription factor 1 | Transcription Factor | E2F1 is involved in prostate cancer cell growth and this activity is regulated by tristetraprolin (TTP). | Reference |
| MYC | V-myc avian myelocytomatosis viral oncogene homolog | Transcription Factor | c-MYC is involved in anchorage independent prostate cancer cell growth through regulating ezrin protein expression in an androgen dependent way. | Reference |
| RUNX2 | Runt-related transcription factor 2 | Transcription Factor | RUNX2 is involved in prostate cancer cell growth in an androgen responsive ways. | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | STAT3 mediates IL-6 induced growth inhibition in androgen dependent prostate cancer cells. | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | STAT3 is associated with prostate cancer cell growth as inhibition of STAT3 activity results in suppression of cell growth in DU145 prostate cancer cells. | Reference |
| SMAD3 | SMAD family member 3 | Transcription Regulatory Protein | SMAD3 play a critical role in prostate cancer cell growth in androgen-independent PC-3MM2 prostate cancer cells | Reference |
| PDE4D | Phosphodiesterase 4D, cAMP-specific | Enzyme Phosphodiesterase | PDE4D is involved in prostate cancer cell growth as knock down of this gene reduced the growth rate of prostate cancer cells in vivo. | Reference |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | Adaptor Protein | DAB2 mediated signaling is involved in the modulation of androgen mediated cell growth in both normal and malignant prostate epithelial cells | Reference |
| BAK1 | BCL2-antagonist/killer 1 | Adaptor Protein | miR-125b mediated suppression of BAK1 results in androgen independent growth of prostate cancer cells | Reference |
| BIN1 | Bridging integrator 1 | Adaptor Protein | Functions as a prostate cancer cell growth suppressor. | Reference |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | Adaptor Protein | Plays a role steroid hormone stimulated prostate cancer cell growth. | Reference |
| CRKL | v-crk avian sarcoma virus CT10 oncogene homolog-like | Adaptor Protein | CRKL interacts with androgen receptor (AR) and use an alternative growth factor signaling in prostate cancer | Reference |
| DVL2 | Dishevelled segment polarity protein 2 | Adaptor Protein | Enhances prostate cancer growth potential by up regulating AR expression in androgen dependent prostate cancer cell line. | Reference |
| FHL2 | Four and a half LIM domains 2 | Adaptor Protein | FHL2 is associated with constitutive activation of AR-mediated growth signals in prostate cancer | Reference |
| SOCS1 | Suppressor of cytokine signaling 1 | Adaptor Protein | SOCS1 acts as a negative growth regulator in prostate cancer | Reference |
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase | Knock down of BMPR2 receptor enhance in vitro cell growth in prostate cancer PC3 cell. | Reference |
| IGF1R | Insulin-like growth factor 1 receptor | Receptor Tyrosine Kinase | IGF1R is transcriptionally regualted by transcription factor Early Growth Response-1 (EGR-1) and is involved in prostate cancer cell growth. | Reference |
| IGF1R | Insulin-like growth factor 1 receptor | Receptor Tyrosine Kinase | IGF-IR promotes prostate cancer growth by stabilizing alpha5beta1 integrin protein levels. | Reference |
| EPHB2 | EPH receptor B2 | Receptor Tyrosine Kinase | EPHB2 play an important roles in Prostate cancer cell growth as its transfection in DU 145 cells which lack the EPHB2 suppresses clonogenic growth. | Reference |
| PDGFRB | Platelet-derived growth factor receptor, beta polypeptide | Receptor Tyrosine Kinase | PDGFR is involved in prostate cancer cell growth as siRNA mediated silencing of PDGFRB in mouse model results in reduction of cell growth in prostate cancer. | Reference |
| AXL | AXL receptor tyrosine kinase | Receptor Tyrosine Kinase | AXL is an important regulator of prostate cancer cell growth as inhibition of AXL gene expression results in suppression of prostate cancer cell growth. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | EGFR is associated with prostate cancer cell growth through both paracrine and autocrine manner. | Reference |
| NTRK1 | Neurotrophic tyrosine kinase, receptor, type 1 | Receptor Tyrosine Kinase | NTRK1 is involved in prostate cancer epithelial cell growth. | Reference |
| RET | Ret proto-oncogene | Receptor Tyrosine Kinase | RET is associated in the growth of both benign and neoplastic prostate epithelial cells. | Reference |
| FGFR1 | Fibroblast growth factor receptor 1 | Receptor Tyrosine Kinase | Androgen insensitive prostate cancer in vivo cell growth is mediated by FGF7 and its receptor FGFR1 under condition of androgen ablation. | Reference |
| MET | Met proto-oncogene | Receptor Tyrosine Kinase | HGF and c-MET is involved in androgen independent prostate cancer cell growth in CWR22R prostate cancer cell line. | Reference |
| ERBB2 | V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | Receptor Tyrosine Kinase | Mediates prostate cancer cell growth regulation in androgen dependent prostate cancer cell line; phosphorylated by prostatic acid phosphatase (cPAcP); involved in castration resistance. | Reference |
| PRLR | Prolactin receptor | Receptor Tyrosine Kinase | Prolactin enhances prostate cancer cell growth via PRLR-JAK2 mediated signaling | Reference |
| IL6ST | Interleukin 6 signal transducer | Cytokine Receptor | IL6 enhance prostate cancer cell growth through IL6ST(GP130)-JAK2-STAT3 mediated signaling pathway in LNCaP human prostate cancer cells. | Reference |
| IL6ST | Interleukin 6 signal transducer | Cytokine Receptor | IL6 is an autocrine growth factor mediates its effects on prostate cancer cell growth through JAK-STAT signalin | Reference |
| IL6ST | Interleukin 6 signal transducer | Cytokine Receptor | Prostaglandin E2 enhances prostate cancer cell growth via activation of IL6/IL6ST/STAT3 signaling | Reference |
| CXCR4 | Chemokine (C-X-C motif) receptor 4 | G protein Coupled Receptor | CXCR4 antagonists inhibits tumour growth in PC-3 xenograft model by suppressing CXCR4 mediated signaling | Reference |
| GHR | Growth hormone receptor | Cell Surface Receptor | Growth hormone receptor(GHR) shows an important role in prostate cancer cell growth and in present in the epithelial cells of the tumour acini. | Reference |
| PHB | Prohibitin | Adaptor Protein | Prohibitin(PHB) is down regulated by androgen and enhances androgen stimulated growth and cell cycle entry in prostate cancer. | Reference |
| EPOR | Erythropoietin receptor | Cell Surface Receptor | Erythropoietin -Erythropoietin receptor(EPOR) system is involved in human prostate cancer growth regulation through STAT5B phosphorylation. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Ar is involved in prostate cancer cell growth via AMPK-PGC-1alpha signaling cascade, a known homeostatic mechanism, to increase prostate cancer cell growth | Reference |
| AR | Androgen receptor | Nuclear Receptor | Regulates prostate cancer cell growth through a metabolic switch; promotes growth through ELK1; enhance cell growth through a ternary membrane associated complex with c-Src. | Reference |
| VAV3 | Vav 3 guanine nucleotide exchange factor | Guanine Nucleotide Exchange Factor | VAV3 is involved in prostate cancer cell growth in LNCaP prostate cancer cell line. | Reference |
| ST7 | Suppression of tumorigenicity 7 | Cell Cycle Control Protein | ST7 is involved in influencing the prostate cancer cell growth as ST7 suppressed the prostate cancer cell growth of PC-3 prostate cancer cells inoculated subcutaneously into severe combined immunodeficient(SCID) mice. | Reference |
| CDKN1A | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) | Cell Cycle Control Protein | CDKN1A(p21) is involved in prostate cancer cell growth as a downstream effector of PI3K-Akt cell growth survival pathway. | Reference |
| CDKN1A | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) | Cell Cycle Control Protein | CDKN1A(p21) is involved in prostate cancer cell growth as Naftopidil, a selective alpha-1 adrenoceptor antagonist targets p21 inhibits the growth of PC-3 cells. | Reference |
| CEACAM1 | Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | Adhesion Molecule | CEACAM1 play a role in growth suppression of prostate cancer cells. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Beta catenine(CTNNB1) is involved in prostate cancer cell growth as inhibitor targeting beta catenine suppressed prostate cancer cell growth. | Reference |
| MAPK14 | Mitogen-activated protein kinase 14 | Serine/Threonine Kinase | MAPK14(p38 alpha) is associated with aggressive growth of prostate cancer cell in LNCaP prostate cancer cell line . | Reference |
| MAPK3 | Mitogen-activated protein kinase 3 | Serine/Threonine Kinase | MAPK3(ERK1) is associated with prostate cancer cell growth through PKCepsilon/PKD3 pathway. | Reference |
| RAF1 | V-raf-1 murine leukemia viral oncogene homolog 1 | Serine/Threonine Kinase | RAF1 play an important role in growth suppresion of prostate cancer through RAF/MEK/MAPK pathway activation. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | AKT1 is involved in prostate tumour cell growth as a downstream effector of CXCL12/CXCR4 mediated signaling in DU145 prostate cancer cell line. | Reference |
| PRKCE | Protein kinase C, epsilon | Serine/Threonine Kinase | PRKCE is associated with prostate cancer epithelial cell growth. | Reference |
| PRKCD | Protein kinase C, delta | Serine/Threonine Kinase | PRKCD is involved in prostate cancer cell growth in an Androgen receptor(AR) dependent manner in both hormone sensitive and castration resistant prostate cancer. | Reference |
| CDK5 | Cyclin-dependent kinase 5 | Serine/Threonine Kinase | CDK5 plays a role in prostate cancer cell growth by regulating androgen receptor stability. | Reference |
| GSK3B | Glycogen synthase kinase 3 beta | Serine/Threonine Kinase | GSK3B is involved in both androgen dependent and androgen independent prostate cancer cell growth through GSK-3/AR signaling axis. | Reference |
| JAK2 | Janus kinase 2 | Tyrosine Kinase | JAK2 is involved in both primary and castration resistant prostate cancer cell growth through JAK2-STAT5 mediated signaling as JAK2 inhibitor suppress both types of prostate cancer cell growth. | Reference |
| FYN | FYN oncogene related to SRC, FGR, YES | Tyrosine Kinase | FYN play an important role in prostate cancer cell growth mediated by HGF/MET signaling axis. | Reference |
| NRBP1 | Nuclear receptor binding protein 1 | Adaptor Protein | NRBP1 is upregulated during prostate cancer pathogenesis and involved in prostate cancer cell growth. | Reference |
| SRC | V-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog | Tyrosine Kinase | SRC play an important role in prostate cancer cell growth through Src/FAK/Rho GTPase signaling pathway. | Reference |
| ADAM12 | ADAM metallopeptidase domain 12 | Metallo Protease | ADAM12 is involved in tuour growth and development in the mouse model of prostate cancer. | Reference |
| PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta | Lipid Kinase | PIK3CB is involved in prostate cancer cell growth through PIK3 pathway activation in PTEN deficient prostate tumour xenograft model. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Mediates PAK6 activation and associated with prostate cancer cell growth. | Reference |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | Adaptor Protein | Involved in non genomic androgen mediated prostate cancer cell growth regulation. | Reference |
| MYC | V-myc avian myelocytomatosis viral oncogene homolog | Transcription Factor | Mediates prostate cancer cell growth regulation through interaction with ROCK in androgen independent prostate cancer cell line. | Reference |
| RUNX2 | Runt-related transcription factor 2 | Transcription Factor | Nitric oxide regulates RUNX2 (a transcription factor), which is highly expressed in human prostate tumour and plays a role in prostate cancer cell growth. | Reference |
| ACSL4 | Acyl-CoA synthetase long-chain family member 4 | Enzyme | Long-chain fatty acyl-CoA synthetase 4 (ACSL4) critically mediates human prostate cancer cell growth through activation of several signaling components including AKT, LSD1 and CTNNB1. | Reference |
| CHEK2 | Checkpoint kinase 2 | Serine/Threonine Kinase | Checkpoint kinase 2 (CHK2), a critical negative growth regulator which is lost during prostate cancer progression to castration resistance, plays a very significant role in prostate cancer cell growth. | Reference |
| TOP2A | Topoisomerase (DNA) II alpha | Enzyme | DNA topoisomerase 2 alpha (TOP2A), overexpressed in advanced human prostate cancer, plays a role in prostate cancer cell growth through activation of androgen receptor (AR) mediated signaling. | Reference |
| MAPK1 | Mitogen-activated protein kinase 1 | Serine/Threonine Kinase | MAPK1 play a very important role in human prostate cancer cell growth as its regulator MiR-378 is significantly downregulated during prostate cancer development . | Reference |
| HAMP | Hepcidin antimicrobial peptide | Unclassified | Hepcidin (HAMP), a central iron regulator which is highly expressed in human prostate cancer cell, plays a role in prostate cancer cell growth. | Reference |
| TCTN1 | Tectonic family member 1 | Unclassified | TCTN1, which is involved in human embryonic development, plays a role in human prostate cancer associated cell growth. | Reference |
| YAP1 | Yes associated protein 1 | Transcription Regulatory Protein | Yes-associated protein (YAP), a crucial effector of the hippo tumor suppressor pathway, plays a role in the regulation of human prostate cancer associated cell growth and there by mediates castration resistance. | Reference |