| Protein | Protein Name | Molecular Type | Evidence | Reference |
|---|
| SP1 | Sp1 transcription factor | Transcription Factor | SP1 is associated with prostate cancer cell proliferation. | Reference |
| E2F1 | E2F transcription factor 1 | Transcription Factor | E2F1 is involved in prostate cancer cell proliferation and this activity is regulated by tristetraprolin (TTP). | Reference |
| MYC | V-myc avian myelocytomatosis viral oncogene homolog | Transcription Factor | c-MYC is involved in prostate cancer cell proliferation as targeted reduction of c-MYC results in suppression of cell proliferation in prostate cancer cell line LNCaP. | Reference |
| SMAD4 | SMAD family member 4 | Transcription Factor | SMAD4 inactivation accelarates prostate cancer cell proliferation | Reference |
| E2F2 | E2F transcription factor 2 | Transcription Factor | E2F2 is involved in prostate cancer cell proliferation as microRNA let-7a targets E2F2 and inhibits proliferation of human prostate cancer cell in vitro and in vivo. | Reference |
| LPXN | Leupaxin | Adaptor Protein | Leupaxin(LPXN) knock down significantly reduces proliferation rate of LNCaP cells. | Reference |
| FOXO1 | Forkhead box O1 | Transcription Factor | CDK1 play an important role in prostate cancer cell proliferation by phosphorylation and inhibition of tumour suppressor gene FOXO1. | Reference |
| EEF1A1 | Eukaryotic translation elongation factor 1 alpha 1 | Transcription Regulatory Protein | Eukaryotic elongation factors EEF1A1 is involved in prostate cancer cell proliferation in prostate cancer cell line LNCaP, DU-145, PC-3. | Reference |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | GTPase | RAC1 play an important role in androgen independent prostate cancer cell proliferation, supported by both in vitro and in vivo experiments | Reference |
| KRAS | Kirsten rat sarcoma viral oncogene homolog | GTPase | KRAS is involved in prostate cancer cell proliferation as miR-143 targets KRAS suppressed prostate cancer cell proliferation. | Reference |
| PDE4D | Phosphodiesterase 4D, cAMP-specific | Enzyme Phosphodiesterase | PDE4D is associated with prostate cancer as a proliferation promoting factor as knockdown of this gene suppressed the the proliferation rate of prostate cancer xenograft in vivo. | Reference |
| SOCS3 | Suppressor of cytokine signaling 3 | Adaptor Protein | Inhibition of SOCS3 by siRNA results in suppression of proliferation in prostate cancer cells | Reference |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | Adaptor Protein | PKC mediated phosphorylation of DAB2 protein regulates its inhibitory function in cell proliferation | Reference |
| GNB2L1 | Guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 | Adaptor Protein | GNB2L1(RACK1) is involved in prostate cancer cell proliferation in both in vito and in viovo | Reference |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | Adaptor Protein | SHC1(p52SHC) is involved in androgen stimulated cell proliferation in LNCaP prostate cancer cells. | Reference |
| YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | Adaptor Protein | 14-3-3 zeta (YWHAZ) interacts with AR and promotes prostate cancer cell proliferation in an androgen responsive way | Reference |
| DVL2 | Dishevelled segment polarity protein 2 | Adaptor Protein | Silencing of DVL2 expression decrease cell proliferation, motility , Cell Invasion and Wnt-3a, AR, MMP-2, MMP-9 expression in LNCaP prostate cancer cell | Reference |
| WASF1 | WAS protein family, member 1 | Adaptor Protein | miR-203 is a tumor suppressor and often downregulated in Prostate cancer, targets WASF1 mRNA and involved in Prostate cancer cell proliferation | Reference |
| TGFBR2 | Transforming growth factor, beta receptor II | Receptor Serine/threonine Kinase | During endothelial & perineural invasion TGF beta mediated enhanced secretion of CAV1 into the tumor microenvironment causes marked increase of proliferative activity in prostate cancer cell | Reference |
| IGF1R | Insulin-like growth factor 1 receptor | Receptor Tyrosine Kinase | IGF1R is involved in prostate cancer cell survival as siRNA mediated silencing of IGF1R results in reduction of cell survival in prostate cancer PC-3 cells. | Reference |
| AXL | AXL receptor tyrosine kinase | Receptor Tyrosine Kinase | AXL is an important regulator of prostate cancer cell proliferation as inhibition of AXL gene expression results in suppression of prostate cancer cell proliferation. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | EGFR is involved in prostate cancer cell proliferation in an ADAM17 induced and EGFR/PI3K/AKT pathway. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | EGFR plays an important role in prostate cancer cell proliferation as microRNA targeting EGFR suppressed cell proliferation in androgen insensitive cell line PC3 and DU145. | Reference |
| FGFR1 | Fibroblast growth factor receptor 1 | Receptor Tyrosine Kinase | FGF2 & its receptor FGFR1 is involved in prostate cancer epithelial cell proliferation. | Reference |
| ERBB2 | V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | Receptor Tyrosine Kinase | Both EGFR and ERBB2 is involved in prostate cancer cell proliferation. | Reference |
| PRLR | Prolactin receptor | Receptor Tyrosine Kinase | Inhibition of prolactin receptor by endocannabinoids results in suppression of prostate cancer cell proliferation | Reference |
| CXCR4 | Chemokine (C-X-C motif) receptor 4 | G protein Coupled Receptor | CXCR4 mediated signaling is involved in prostate cancer epithelial cell proliferation | Reference |
| GHR | Growth hormone receptor | Cell Surface Receptor | Growth hormone receptor(GHR) is involved in prostate cancer cell proliferation in androgen-dependent LNCaP cells. | Reference |
| PHB | Prohibitin | Adaptor Protein | Prohibitin(PHB), a cell cycle regulatory protein is involved in prostate cancer cell proliferation in an androgen receptor dependent manner in LNCaP cells. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Cell proliferation is linked to ribosome biogenesis which is stimulated by AR and Estrogen receptor signaling in prostate cancer | Reference |
| GOLM1 | Golgi membrane protein 1 | Transport/Cargo Protein | Golgi membrane protein 1 (GOLM1) is involved in prostate cancer cell proliferation as inhibition of GOLM1 results in significant suppression of prostate cancer cell proliferation. | Reference |
| CDKN1B | Cyclin-dependent kinase inhibitor 1B (p27, Kip1) | Cell Cycle Control Protein | CDKN1B(p27) is involved in androgen independent prostate cancer cell proliferation as SOX2 targets p27 and regulate prostate cancer cell proliferation. | Reference |
| CDKN1B | Cyclin-dependent kinase inhibitor 1B (p27, Kip1) | Cell Cycle Control Protein | Inhibition of FOXO3a-mediated activation of the p27 gene by the high aberrant expression of c-Myc in many tumor cells likely contributes to their uncontrolled proliferation and invasive phenotype. | Reference |
| PIAS1 | Protein inhibitor of activated STAT, 1 | Cell Cycle Control Protein | Protein inhibitor of activated signal transducers and activators of transcription (PIAS)1 play an important role in regulation of cell proliferation in prostate cancer through inhibition of p21.. | Reference |
| FRS2 | Fibroblast growth factor receptor substrate 2 | Adaptor Protein | FRS2 is involved in prostate cancer cell proliferation in a FGF-FGFR dependent signaling in DU145 cells. | Reference |
| ITGB4 | Integrin, beta 4 | Adhesion Molecule | (ITGB4)beta4 integrin enhance human prostate cancer cell proliferation by amplifying receptor tyrosine kinase mediated signaling. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Beta catenine(CTNNB1) is associated with prostate cancer cell proliferation as lupeol targets beta catenine and inhibits proliferation of prostate cancer cell. | Reference |
| MAPK3 | Mitogen-activated protein kinase 3 | Serine/Threonine Kinase | MAPK3(ERK1) activation through PI3K mediated signaling play an important role in prostate cancer cell proliferation. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | AKT1 play an important role in prostate cancer cell proliferation through EGF-EGFR & ERBB2 mediated signaling. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | AKT1 play an important role in prostate cancer cell proliferation through GAS6-AXL mediated signaling. | Reference |
| FRS3 | Fibroblast growth factor receptor substrate 3 | Adaptor Protein | FRS3 is involved in prostate cancer cell proliferation in a FGF-FGFR dependent signaling in DU145 cells. | Reference |
| PLK1 | Polo-like kinase 1 | Serine/Threonine Kinase | PLK1 plays an important role during mitotic entry of prostate cancer cell proliferation. | Reference |
| GSK3B | Glycogen synthase kinase 3 beta | Serine/Threonine Kinase | GSK3B is involved in both androgen dependent and androgen independent prostate cancer cell proliferation through GSK-3/AR signaling axis. | Reference |
| FYN | FYN oncogene related to SRC, FGR, YES | Tyrosine Kinase | FYN is involved in the prostate cancer cell proliferation through both integrin and receptor tyrosine kinase mediated manner. | Reference |
| PXN | Paxillin | Cytoskeletal Associated Protein | Paxillin(PXN) play an important role in both androgen and growth factor mediated cell proliferation by modulating ERK mediated signaling in both castration sensitive and castration resistant prostate cancer. | Reference |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | Membrane transport protein | ATP2A2(SERCA2) is involved in prostate call proliferation in a prolactin mediated manner in SV40 immortalized epithelial prostate (PNT1A) cells. | Reference |
| PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta | Lipid Kinase | PIK3CB is involved in prostate cancer abnormal cell proliferation through PIK3 pathway activation in PTEN deficient prostate tumour xenograft model. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Involved in prostate cancer cell proliferation in androgen independent PC-3 and DU-145 prostate cancer cell line. | Reference |
| FOXO1 | Forkhead box O1 | Transcription Factor | Downregulation of FOXO1 expression in human prostate cancer through MiR-182, plays a role in enhancement of prostate cancer cell proliferation. | Reference |
| FOXO3 | Forkhead box O3 | Transcription Factor | FOXO3, a member of the forkhead transcriptional factor family, is repressed by tumour suppressor MiR-592 and thereby contributes to prostate cancer cell proliferation through upregulation of cyclin D1 and down regulation of p21. | Reference |
| HEC1 | NDC80 kinetochore complex component | Cell Cycle Control Protein | HEC1, a kinetochore complex component, which is overexpressed in human prostate cancer and plays an important role in prostate cancer cell proliferation through regulating long non-coding RNA BX647187. | Reference |
| PSGR | Prostate | G protein Coupled Receptor | Prostate specific G protein coupled receptor (PSGR) promotes human prostate cancer cell proliferation through activation of PI3K, MAPK and SRC mediated signaling. | Reference |
| PIN1 | Peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | Enzyme | Peptidyl-prolyl isomerase PIN1 plays a role in human prostate cancer associated cell proliferation through activation of WNT/beta-catenine mediated signaling. | Reference |
| CX3CL1 | Chemokine (C-X3-C motif) ligand 1 | Chemokine | Fractalkine (CX3CL1), a membrane?bound chemokine, is involved in human prostate cancer cell proliferation through mediating G1-S phase cell cycle transition in an hypoxia responsive manner. | Reference |
| JMJD1A | Lysine (K)-specific demethylase 3A | Unclassified | Histone demethylase JMJD1A plays a role in human prostate cancer cell proliferation through regulating c-MYC expression at both transcriptional and post-transcriptional level. | Reference |
| CUL1 | Cullin 1 | Ubiquitin proteasome system protein | Cullin-1 (CUL1), which is highly expressed in human prostate cancer, is involved in prostate cancer associated cell proliferation through regulation of cell cycle. | Reference |
| FGF19 | Fibroblast growth factor 19 | Growth Factor | FGF19, highly expressed in human prostate cancer, plays a role in prostate cancer cell proliferation. | Reference |
| ARR2 | Arrestin, beta 2 | Adaptor protein | Beta arrestin2 (ARR2), a ubiquitous scaffolding/adaptor protein, plays a role in castration resistant prostate cancer (CRPC) associated cell proliferation through downregulation of FOXO1 activity and expression. | Reference |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 | Extracellular Matrix Protein | EFEMP1 inactivation through promoter methylation, plays a role in human prostate cancer associated cell proliferation. | Reference |
| UBE2T | Ubiquitin conjugating enzyme E2T | Ubiquitin proteasome system protein | Ubiquitin-conjugating enzyme E2T (UBE2T), which is highly expressed in human prostate cancer, plays a role in human prostate cancer associated cell proliferation. | Reference |
| RAP1A | RAP1A, member of RAS oncogene family | GTPase | RAP1A, which is upregulated in human prostate cancer, plays a role in prostate cancer associated cell proliferation as its critical negative regulator MiR-203 is significantly downregulated in human prostate cancer. | Reference |