| Protein | Protein Name | Molecular Type | Feature | Evidence | Reference |
|---|
| E2F1 | E2F transcription factor 1 | Transcription Factor | Cell Cycle | E2F1 is associated with cell cycle regulation in prostate cancer as targeted reduction in activity of E2F1 results in reduction of cell cycle regulatory programs in prostate cancer. | Reference |
| TP53 | Tumor protein p53 | Transcription Factor | Tumor Suppression | TP53 functions as a tumour suppressor and suffers from mutation in prostate cancer. | Reference |
| TP53 | Tumor protein p53 | Transcription Factor | Tumor Suppression | Tumour suppressor TP53 mutations in exon 7 and exon 8 are factors of tumor progression in PCa. | Reference |
| SMAD4 | SMAD family member 4 | Transcription Factor | Tumor Suppression | miR-888 expressions are increased in advanced prostate cancer and miR-888 targets and lowers the expression levels of tumour suppressor SMAD4. | Reference |
| SMAD4 | SMAD family member 4 | Transcription Factor | Tumor Suppression | SMAD4 is a tumor suppressor located on chromosome 18q21.1 and its expression levels are reduced in prostate cancer tissues compared to normal prostate. | Reference |
| WT1 | Wilms tumor 1 | Transcription Factor | Tumor Suppression | Wilm's tumour gene (WT1) function as a tumour suppressor in prostate cancer progression by regulating prostate tumour cell growth. | Reference |
| FOXO1 | Forkhead box O1 | Transcription Factor | Tumor Suppression | Aberrant activation of CDK1 and CDK2 results in phosphorylation and inactivation of FOXO1, inhibiting its tumour suppressive function. | Reference |
| FOXO1 | Forkhead box O1 | Transcription Factor | Tumor Suppression | FOXO1 play a crucial role in prostate cancer tumor suppression by acting as a key downstream effector of PTEN. | Reference |
| RB1 | Retinoblastoma 1 | Transcription Regulatory Protein | Tumor Suppression | RB1 function as a tumour suppressor gene in prostate cancer as RB1 loss induces E2F1 mediated deregulation of the AR locus. | Reference |
| SMAD3 | SMAD family member 3 | Transcription Regulatory Protein | Tumor Suppression | TGF beta induced SMAD3 mediated signaling have a tumor suppressive activity in castration resistant prostate cancer. | Reference |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | GTPase | Tumor Suppression | RAC1 is involved in Cyclin D1 mediated cell cycle regulation through PAK1 in androgen independent prostate cancer cell. | Reference |
| SMAD2 | SMAD family member 2 | DNA Binding Protein | Tumor Suppression | SMAD2 functions as a tumor suppressor in basal epithelia of prostate cancer NRP-152 cells. | Reference |
| SMAD2 | SMAD family member 2 | DNA Binding Protein | Tumor Suppression | TGF beta induced SMAD2 mediated signalling have a tumor suppressive activity in castration resistant prostate cancer. | Reference |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | Adaptor Protein | Tumor Suppression | DAB2 functions as a potent tumour suppressor in prostate cancer; functions as a negative regulator of cell growth. | Reference |
| BIN1 | Bridging integrator 1 | Adaptor Protein | Tumor Suppression | BIN1 is the chromosome 2q prostate tumour suppressor gene and frequently deleted in metastatic prostate cancer; Its inactivation contributes to the enhancement of c-MYC mediated oncogenic function . | Reference |
| ANK1 | Ankyrin 1, erythrocytic | Adaptor Protein | Tumor Suppression | ANK1 tumour suppressor present on 8p22 is frequently deleted in both metastatic and localized prostate cancer specimens. | Reference |
| BECN1 | Beclin 1, autophagy related | Adaptor Protein | Tumor Suppression | BECN1 is implicated as a haploinsufficient tumour suppressor in prostate cancer; located on chromosome 17q21 that is commonly deleted in breast, ovarian, and prostate cancer. | Reference |
| TGFBR2 | Transforming growth factor, beta receptor II | Receptor Serine/threonine Kinase | Tumor Suppression | It functions as a tumor suppressor in early tumorigenesis; it follows loss of expression, epigenetic silencing, mutation and down regulation during prostate tumorigenesis. | Reference |
| TGFBR2 | Transforming growth factor, beta receptor II | Receptor Serine/threonine Kinase | Tumor Suppression | Overexpression of TGFBR2 LNCaP prostate cancer cells induces prostate tumorigenic suppression by caspase dependent apoptosis | Reference |
| TGFBR2 | Transforming growth factor, beta receptor II | Receptor Serine/threonine Kinase | Tumor Suppression | Although TGF-beta inhibits the proliferation of normal prostate cells and functions as a tumor suppressor in early tumorigenesis, it acts as a tumor promoter in later stages of tumor progression | Reference |
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase | Tumor Suppression | BMP-9 is a putative tumor suppressor in prostate cancer and and in thses functional context BMPR2 is required for its function | Reference |
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase | Tumor Suppression | BMP-9 is a putative tumor suppressor in prostate cancer and BMPR2 is required for its function | Reference |
| EPHB2 | EPH receptor B2 | Receptor Tyrosine Kinase | Tumor Suppression | EPHB2 is implicated as a prostate cancer tumour suppressor gene with somatic inactivating mutations occurring in ?10% of sporadic prostatic tumours. | Reference |
| PHB | Prohibitin | Adaptor Protein | Tumor Suppression | PHB acts as a tumour suppressor and AR co repressor in prostate cancer; It is targeted by miR-27a, which is regulated by AR. | Reference |
| PHB | Prohibitin | Adaptor Protein | Tumor Suppression | PHB mediates tumour suppressive effects in prostate cancer and is involved in maintaining a balance between cell survival and apoptosis | Reference |
| PHB | Prohibitin | Adaptor Protein | Cell Cycle | Prohibitin(PHB) has a nuclear regulatory role in prostate cancer. | Reference |
| NGFR | Nerve growth factor receptor | Cell Surface Receptor | Tumor Suppression | NGFR(p75NTR) tumour suppressor is lost during prostate cancer progression and is involved in regulation of apoptosis via intrinsic mitochondrial pathway. | Reference |
| ST7 | Suppression of tumorigenicity 7 | Cell Cycle Control Protein | Tumor Suppression | ST7 located on chromosome 7q31.1 functions as a tumour suppressor in prostate cancer by mediating modification of tumour microenvironments. | Reference |
| CDKN1B | Cyclin-dependent kinase inhibitor 1B (p27, Kip1) | Cell Cycle Control Protein | Tumor Suppression | CDKN1B (p27) located on chromosome 16q, functions as a tumour suppressor in prostate cancer due to allelic loss and LOH. | Reference |
| CDKN1B | Cyclin-dependent kinase inhibitor 1B (p27, Kip1) | Cell Cycle Control Protein | Cell Cycle | CDKN1A(p21) play an important role in prostate cancer cell cycle arrest along with CDK4. | Reference |
| CDKN1A | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) | Cell Cycle Control Protein | Tumor Suppression | CDKN1A (p21) acts as a tumour suppressor during prostate tumorigenesis because of promoter hypermethylation. | Reference |
| CDKN1A | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) | Cell Cycle Control Protein | Cell Cycle | CDKN1A(p21) play an important role in prostate cancer cell cycle arrest along with CDK4. | Reference |
| CEACAM1 | Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | Adhesion Molecule | Tumor Suppression | CEACAM1 play a tumor suppressive role in prostate cancer due to its ability to inhibit angiogenesis. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Cell Cycle | AKT1 mediates an enhancement of Skp2 expression and there by promotes p27 destruction, that results in prostate cancer cell cycle deregulation. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Cell Cycle | PI3K/AKT1 mediates prostate cancer cell cycle deregulation through the activation of AKT/mTOR/p70(S6K) signaling pathway | Reference |
| PLK1 | Polo-like kinase 1 | Serine/Threonine Kinase | Cell Cycle | PLK1 is overexpressed in prostate cancer and associated with deregulation of cell cycle and mitotic entry. | Reference |
| PLK1 | Polo-like kinase 1 | Serine/Threonine Kinase | Cell Cycle | Polo-like kinase 1 (PLK1) is associated with mitotic mechinery in prostate cancer as Si RNA mediated silencing of PLK1 results in mitotic cell cycle arrest and defects in centrosome integrity. | Reference |
| FYN | FYN oncogene related to SRC, FGR, YES | Tyrosine Kinase | Tumor Suppression | FYN functions as a prostate cancer tumour suppressor in the altered biochemical landscape of neoplastic transformation. | Reference |
| FYN | FYN oncogene related to SRC, FGR, YES | Tyrosine Kinase | Tumor Suppression | FYN located at chromosome 6q21 play a tumour suppressive role during prostate cancer progression; suffers from chromosomal deletion & promoter hypermethylation.. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Cell Cycle | Androgen receptor(AR) plays a very crucial role in androgen independent prostate cancer cell cycle progression through upregulation of M-phase cell cycle genes. | Reference |
| PXN | Paxillin | Cytoskeletal Associated Protein | Cell Cycle | Paxillin, a cytoplasmic adaptor protein is significantly involved in prostate cancer cell cycle through regulating c-FOS and cyclin D1 expression. | Reference |
| FGFR1 | Fibroblast growth factor receptor 1 | Receptor Tyrosine Kinase | Cell Cycle | FGFR-1 plays a role in prostate cancer cell cycle progression, through mediating G2 to M phase transition. | Reference |
| FADD | Fas (TNFRSF6)-associated via death domain | Adaptor Protein | Cell Cycle | Adapter protein FADD is critically involved in prostate cancer associated G2 to M phase cell cycle transition. | Reference |
| BCL2L1 | BCL2-like 1 | Adaptor Protein | Cell Cycle | BCL2L1(BCL-XL), which is overexpressed in human prostate cancer plays a role in G1 to S phase transition of prostate cancer cell cycle in an androgen receptor(AR) dependent manner. | Reference |
| DVL2 | Dishevelled segment polarity protein 2 | Adaptor Protein | Cell Cycle | DVL2 plays a role in G1 to S phase transition of prostate cancer cell cycle by targeting cyclin D1 through KIF3a-DVL2-?-catenin axis. | Reference |
| NGFR | Nerve growth factor receptor | Cell Surface Receptor | Tumor Suppression | NGFR [p75(NTR)], a tumour suppressor which is lost during the course of prostate tumorigenesis, plays a significant role in regulation of prostate cancer cell cycle. | Reference |
| FOXO1 | Forkhead box O1 | Transcription Factor | Tumor Suppression | FOXO1A, which is downregulated in human prostate cancer, plays an important tumour suppressive role through inhibition of androgen receptor signaling and suppression of prostate cancer cell proliferation. | Reference |
| MED1 | Mediator complex subunit 1 | Transcription Regulatory Protein | Tumor Suppression | TGFBR3 functions as a tumour suppressor gene in human prostate cancer; Its loss of expression is mediated by LOH and epigenetic silencing. | Reference |
| cPAcP | Acid phosphatase, prostate | Acid Phosphatase | Tumor Suppression | cPAcP functions as a negative regulator of cell proliferation and a tumour suppressor in prostate cancer. | Reference |
| SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase | Ubiquitin Proteasome System Protein | Cell Cycle | F-box protein Skp2, an oncoprotein plays an important role in human prostate cancer progression through regulation of multiple cell cycle regulators including p27, p21 and FOXO1. | Reference |
| FUS | FUS RNA binding protein | RNA binding protein | Cell Cycle | FUS/TLS (Fused in Ewing's Sarcoma/Translocated in Liposarcoma) plays a significant role in human prostate cancer associated cell cycle progression in an androgen receptor(AR) dependent manner. | Reference |
| SOX2 | SRY-box 2 | Transcription Factor | Cell Cycle | SOX2 plays a critical role in prostate cancer cell cycle progresson through regulation of cyclin E and p27. | Reference |
| UBE2C | Ubiquitin conjugating enzyme E2C | Ubiquitin Proteasome System Protein | Cell Cycle | UBE2C plays a role in human prostate cancer cell cycle progression, particularly in G2 to M phase. | Reference |
| MED12 | Mediator complex subunit 12 | Transcription Regulatory Protein | Cell Cycle | MED12, overexpressed in castration resistant prostate cancer and plays a role in G1 to S phase cell cycle transition. | Reference |
| LAT1 | Solute carrier family 7 (amino acid transporter light chain, L system), member 5 | Transport/Cargo Protein | Cell Cycle | LAT1, a L-type amino acid transporter, is involved in G2 to M phase transition of human prostate cancer associated cell cyle and there by enhances metastatic castration resistant prostate cancer progression. | Reference |
| LAT3 | Solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 | Transport/Cargo Protein | Cell Cycle | LAT3, a L-type amino acid transporter, is involved in G2 to M phase transition of human prostate cancer associated cell cyle and there by enhances metastatic castration resistant prostate cancer progression. | Reference |
| ADAM17 | ADAM metallopeptidase domain 17 | Metallo protease | Cell Cycle | ADAM17, a transmembrane protein mediates prostate cancer cell cycle progression through EGFR/PI3K/AKT pathway and targets cell cycle regulator p21 and p27. | Reference |
| HOXB13 | Homeobox B13 | Transcription Factor | Cell Cycle | HOXB13, overexpressed in human prostate cancer and plays a crucial role in G1 to S phase and G2 to M phase cell cycle transition. | Reference |
| CDK1 | Cyclin-dependent kinase 1 | Serine/Threonine Kinase | Cell Cycle | Cyclin-dependent kinase 1 (CDK1) plays a leading role in prostate cancer cell cycle progression through inhibition of tumour suppressor FOXO1. | Reference |
| ADAM9 | ADAM metallopeptidase domain 9 | Metallo protease | Cell Cycle | ADAM9 plays a significant role in prostate cancer cell cycle progression, particularly G1 to S phase transition through regulation of p27 ina REG4 dependent manner. | Reference |
| CDK6 | Cyclin-dependent kinase 6 | Cell Cycle Control Protein | Cell Cycle | Cyclin-dependent kinase 6 (CDK6) is associated with G1 to S phase transition of prostate cancer cell cycle through enhancement of androgen receptor activity. | Reference |
| BIRC7 | Baculoviral IAP repeat containing 7 | Unclassified | Cell Cycle | BIRC7(Livin alpha) promotes human prostate cancer cell cycle progresion through regulation of G1 to S phase transition. | Reference |
| ARA70 | Nuclear receptor coactivator 4 | Transcription Regulatory Protein | Tumor Suppression | ARA70, an androgen receptor coactivator functions as a tumour suppressor gene in human prostate cancer and is associated with prostate cancer cell growth and invasion. | Reference |
| IQGAP2 | IQ motif containing GTPase activating protein 2 | GTPase activating protein | Tumor Suppression | IQGAP2, functions as a tumour suppressor in human prostate cancer through regulation of E-cadherin. | Reference |
| ID4 | Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | Transcription Regulatory Protein | Tumor Suppression | ID4, a member of the Id gene family, functions as an important tumour suppressor in human prostate cancer through influencing cell proliferation. | Reference |
| NKX3-1 | NK3 homeobox 1 | Transcription Factor | Tumor Suppression | NKX3.1(NKX3-1), an androgen inducible tumour suppressor which is inactivated during prostate cancer progression, plays an important role in the activation of TMPRSS2-ERG fusions. | Reference |
| ALDH1A2 | Aldehyde dehydrogenase 1 family member A2 | Enzyme | Tumor Suppression | ALDH1A2, encodes an enzyme responsible for synthesis of retinoic acid, functions as a potential tumour suppressor in human prostate cancer. | Reference |
| TGFBR3 | Transforming growth factor, beta receptor III | Cell Surface Receptor | Tumor Suppression | TGFBR3, which is lost during prostate cancer progression, plays a very crucial tumour suppressive role through effecting on prostate cancer cell motility and invasion. | Reference |
| SERPINB5 | Serpin peptidase inhibitor, clade B (ovalbumin), member 5 | Protease inhibitor | Tumor Suppression | The haploinsufficient tumour suppressor maspin (SERPINB5) plays a critical function in regulation of prostate epithelial cell proliferation. | Reference |
| TSC1 | Tuberous sclerosis 1 | Cytoskeletal associated protein | Tumor Suppression | Tuberous sclerosis complex 1 (TSC1), a critical negative regulator of mTORC1 signaling, functions as a potential tumour suppressor in aged mouse. | Reference |
| CHD1 | Chromodomain helicase DNA binding protein 1 | DNA Binding Protein | Tumor Suppression | Chromodomain helicase DNA-binding protein 1 (CHD1), functions as an essential tumour suppressor in prostate cancer through regulation of AR-responsive tumor suppressor genes. | Reference |
| CADM2 | Cell adhesion molecule 2 | Adhesion Molecule | Tumor Suppression | CADM-2 plays a potential tumour suppressive role in the metastaatic progression of prostate cancer. | Reference |
| MT1H | Metallothionein 1H | Unclassified | Tumor Suppression | MT1H, a metal binding protein plays a tumour suppressive role in human prostate cancer through activation of euchromatin histone methyltransferase 1 (EHMT1). | Reference |
| RFWD2 | Ring finger and WD repeat domain 2, E3 ubiquitin protein ligase | Ubiquitin proteasome system protein | Tumor Suppression | Ubiquitin ligase COP1(RFWD2) functions as a tumour suppressor through influencing prostate cancer epithelial cell proliferation. | Reference |
| PAX6 | Paired box 6 | Transcription Factor | Tumor Suppression | The tumour suppressive functions of PAX6 is mainly mediated by suppression of prostate cancer cell growth in an androgen receptor dependent manner. | Reference |
| CFD | Complement factor D (adipsin) | Enzyme | Tumor Suppression | Adiponectin (CFD), a hormone secreted by adipose tissue plays an important tumour suppressive role in human prostate cancer associated epithelial mesenchymal transition (EMT) and is frequently inactivated by promoter methylation. | Reference |
| 15-LOX2 | Arachidonate 15-lipoxygenase, type B | Enzyme | Tumor Suppression | 15-Lipoxygenase-2 (15-LOX2), a human-specific lipid-peroxidizing enzyme which plays a key role in the induction of cellular senescence program, functions as a critical tumour suppressor and is completely lost during prostate cancer progression. | Reference |
| CUL1 | Cullin 1 | Ubiquitin proteasome system protein | Cell Cycle | Cullin-1 (CUL1), which is highly expressed in human prostate cancer, is involved in prostate cancer associated cell proliferation through regulation of cell cycle by regulating the expression of cyclin D, cyclin E, p21 and p27. | Reference |