| Protein | Protein Name | Molecular Type | Feature | Evidence | Reference |
|---|
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | Telomere maintenance | Activation of STAT3 results in enhancement of telomerase reverse transcriptase transcriptional activity in prostate cancer cells. | Reference |
| FADD | Fas (TNFRSF6)-associated via death domain | Adaptor Protein | Telomere maintenance | Phosphorylation of FADD is associated with modulation of Telomerase & Telomerase reverse transcriptase activity in prostate cancer | Reference |
| TGFBR2 | Transforming growth factor, beta receptor II | Receptor Serine/threonine Kinase | Telomere maintenance | Supress telomerase expression | Reference |
| AR | Androgen receptor | Nuclear Receptor | Telomere maintenance | In human cancer telomerase activation can be blocked by anti androgen through suppressing AR signaling | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Telomere maintenance | AKT1 plays an important role in human prostate cancer by mediating posttranslational modification telomerase reverse transcriptase (hTERT) and there by promoting its nulear translocation. | Reference |
| PRKCA | Protein kinase C, alpha | Serine/Threonine Kinase | Telomere maintenance | PRKCA plays a significant role in human prostate cancer by mediating posttranslational modification telomerase reverse transcriptase (hTERT) and there by promoting its nulear translocation. | Reference |
| MYC | V-myc avian myelocytomatosis viral oncogene homolog | Transcription Factor | Telomere maintenance | c-MYC oncogene is significantly associated with stabilization of telomerase reverse transcriptase (hTERT) through up-regulation of hTERT expression in human prostate tumour cell. | Reference |
| IGF1R | Insulin-like growth factor 1 receptor | Receptor Tyrosine Kinase | Telomere maintenance | IGF1 plays a role in human prostate cancer by post translational modification of telomerase reverse transcriptase (hTERT) through IGF1R/PI3K/AKT1 signaling axis. | Reference |
| TP53 | Tumor protein p53 | Transcription Factor | Senescence Downmodulation | Tumour suppressor p53, which is found completely lost during the progression of prostate cancer, plays a vital role in the induction of cellular senescence program. | Reference |
| RB1 | Retinoblastoma 1 | Transcription Regulatory Protein | Senescence Downmodulation | Retinoblastoma 1(RB1), which is inactivated through downregulation of tumour suppressor MiR- 449a, promotes senescence down modulation in human prostate cancer cell. | Reference |
| PINX1 | PIN2/TERF1 interacting, telomerase inhibitor 1 | Unclassified | Telomere maintenance | PINX1(Pin2/TRF1 binding protein X1), an endogenous telomerase inhibitor and an haploinsufficient tumour suppressor suffers from reduced expression and is associated with aggressive feature in human prostate cancer. | Reference |
| TERT | Telomerase reverse transcriptase | Reverse Transcriptase | Telomere maintenance | Enhanced telomerase activity in the patients with prostatic intraepithelial neoplasia(PIN) increases the risk of prostate cancer development | Reference |
| TERT | Telomerase reverse transcriptase | Reverse Transcriptase | Telomere maintenance | Telomerase reactivation in murine prostate tumour by following telomere dysfunction, plays a very significant role in the enhancement of prostate cancer progression. | Reference |
| HIF1A | Hypoxia inducible factor 1, alpha subunit | Transcription Factor | Telomere maintenance | HIF1A plays a role in human prostate cancer associated hTERT expression by interacting with estrogen receptors. | Reference |
| ESR2 | Estrogen receptor 2 (ER beta) | Transcription Factor | Telomere maintenance | Estrogen receptor beta promotes human prostate cancer associated hTERT expression by forming combinatorial complexes ESR2/HIF1A and ESR2/eNOS. | Reference |
| eNOS | Nitric oxide synthase 3 | Enzyme | Telomere maintenance | eNOS plays a role in human prostate cancer associated hTERT expression by interacting with estrogen receptors. | Reference |
| HIF2A | Endothelial PAS domain protein 1 | Transcription Factor | Telomere maintenance | Estrogen receptor beta promotes human prostate cancer associated hTERT expression by forming combinatorial complexes ESR2/HIF1A and ESR2/HIF2A. | Reference |
| BMI1 | BMI1 proto-oncogene, polycomb ring finger | DNA Binding Protein | Telomere maintenance | The polycomb group protein BMI1 promotes human prostate cancer progression by the expression of human telomerase reverse transcriptase (hTERT) activity. | Reference |
| HSP90 | Heat shock protein 90kDa alpha (cytosolic), class A member 1 | Chaperone | Telomere maintenance | Chanerone protein HSP90 plays a very important role human prostate cancer by mediating telomerase assembly and there by enhancing its activity. | Reference |
| P23 | Prostaglandin E synthase 3 (cytosolic) | Chaperone | Telomere maintenance | Chanerone protein p23 plays a significant function in human prostate cancer by mediating telomerase assembly and there by enhancing its activity. | Reference |
| CDKN1C | Cyclin-dependent kinase inhibitor 1C (p57, Kip2) | Cell Cycle Control Protein | Telomere maintenance | Loss of p57(kip2a) plays a crucial role in human prostate cancer development by influencing human telomerase reverse transcriptase (hTERT) activity. | Reference |
| ATM | ATM serine/threonine kinase | Serine/Threonine Kinase | Telomere maintenance | Ataxia-telangiectasia mutated gene product (ATM protein), which is overexpressed in human prostate tumour and plays a crucial role in stabilization of shortened telomeres and there by stabilizing the genomic instability leading to immortalization and tumorigenesis. | Reference |
| PARM1 | Prostate androgen-regulated mucin-like protein 1 | Unclassified | Telomere maintenance | Prostatic androgen-repressed message-1 (PARM-1), which is overexpressed during regression of the prostate after androgen withdrawal plays a role in enhancement of telomerase activity, there by promoting apoptosis resistance. | Reference |
| IGFBP2 | Insulin like growth factor binding protein 2 | Secreted Polypeptide | Telomere maintenance | IGFBP-2 enhances human prostate cancer associated telomerase activity and there by promotes prostate tumorigenesis. | Reference |
| ESR2 | Estrogen receptor 2 (ER beta) | Transcription Factor | Telomere maintenance | Estrogen receptor beta plays a very important role in modulation of telomerase activity in human prostate cancer. | Reference |
| SSB | Sjogren syndrome antigen B (autoantigen La) | RNA Binding Protein | Telomere maintenance | The La autoantigen interacts with the human telomerase RNA (hTR) and the telomerase RNP and there by influences human prostate cancer associated telomere homeostasis. | Reference |
| TLX | Nuclear receptor subfamily 2, group E, member 1 | Nuclear Receptor | Senescence Downmodulation | The orphan nuclear receptor TLX (NR2E1) plays a significant role in suppression of oncogene-induced senescence through transcriptional regulation of two senescence-associated genes in human prostate cancer. | Reference |
| ID4 | Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | Transcription Regulatory Protein | Senescence Downmodulation | Inhibitor of DNA binding 4(ID4), a potential tumor suppressor that is down-regulated through promoter hypermethylation during prostate tumorigenesis, plays a very critical role in induction of senescence program through regulating E2F expresseion. | Reference |
| JUNB | Jun B proto-oncogene | Transcription Factor | Senescence Downmodulation | Transcription factor JUNB, which is downregulated in high-grade prostate cancer and plays an important role in promotion of senscence program. | Reference |
| AGR2 | Anterior gradient 2, protein disulphide isomerase family member | Unclassified | Senescence Downmodulation | Anterior-gradient 2 (AGR2), overexpressed in human prostate cancer and plays a role in regulation of prostate cancer associated senescence. | Reference |
| 15-LOX2 | Arachidonate 15-lipoxygenase, type B | Enzyme | Senescence Downmodulation | 15-Lipoxygenase-2 (15-LOX2), a human-specific lipid-peroxidizing enzyme which is completely lost during prostate cancer progression, plays a key role in the induction of cellular senescence program. | Reference |