| Protein | Protein Name | Molecular Type | Feature | Evidence | Reference |
|---|
| YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | Adaptor Protein | AR Signaling | 14-3-3 (YWHAZ), an adapter protein which is under the transcriptional regulation of androgen receptor (AR), plays a role in human prostate tumorigenesis through activation of cell proliferation and migration. | Reference |
| CDK5 | Cyclin-dependent kinase 5 | Serine/Threonine Kinase | AR Signaling | Cyclin-dependent kinase 5 (Cdk5) critically modulates androgen receptor (AR) mediated signaling and there by promotes human prostate cancer cell growth. | Reference |
| CXCR4 | Chemokine (C-X-C motif) receptor 4 | G protein Coupled Receptor | AR Signaling | CXCR4 plays a critical role in human prostate cancer associated cell proliferation through ligand independent transactivation of | Reference |
| VAV3 | Vav 3 guanine nucleotide exchange factor | Guanine Nucleotide Exchange Factor | AR Signaling | VAV3, a Rho GTPase guanine nucleotide exchange factor that is overexpressed in human prostate cancer plays a role in prostate cancer cell proliferation through activation of androgen receptor (AR) mediated signaling. | Reference |
| ERBB2 | V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | Receptor Tyrosine Kinase | AR Signaling | ERBB2 receptor, which is overexpressed in human prostate cancer, plays an imortant role in activation of androgen receptor (AR) mediated signaling, and there by significantly promotes human prostate cancer progression. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | AR Signaling | EGFR plays a very crucial role in human prostate cancer progression through activation of androgen receptor (AR) mediated signaling through both PI3K/AKT & MAPK pathway and also by direct physical interaction with AR. | Reference |
| IGF1R | Insulin-like growth factor 1 receptor | Receptor Tyrosine Kinase | AR Signaling | Insulin-like growth factor 1 receptor (IGF1R), which is overexpressed in human prostate cancer, plays a crucial role in prostate cancer cell survival through a ‘higher-level’ interaction between androgen receptor(AR). | Reference |
| SMAD4 | SMAD family member 4 | Transcription Factor | AR Signaling | SMAD4 plays a very crucial role in human prostate cancer initiation & progresion through direct physical interaction with androgen receptor (AR). | Reference |
| PTP1B | Protein tyrosine phosphatase, non-receptor type 1 | Tyrosine Phosphatase | AR Signaling | Protein tyrosine phosphatase PTP1B, a metabolic signaling regulator, plays a significant role in human prostate cancer cell growth in an androgen receptor (AR) responsive manner (through transcriptional regulation). | Reference |
| ZEB1 | Zinc finger E-box binding homeobox 1 | Transcription Factor | AR Signaling | Androgen receptor (AR) plays a role in regulation of ZEB1 transcription factor, which is significantly associated with human prostate cancer development. | Reference |
| ACK1 | Tyrosine kinase, non-receptor, 2 | Tyrosine Kinase | AR Signaling | ACK1, a growth factor regulated tyrosine kinase, phosphorylates androgen receptor (AR), which up-regulates the expression of ATM (a critical regulator of the DNA damage checkpoint response pathways) and there by promotes radiation resistance in castration resistant prostate cancer (CRPC) | Reference |
| ELK1 | ELK1, member of ETS oncogene family | Transcription Factor | AR Signaling | ELK1, an ETS domain transcription factor, interacts with androgen receptor (AR) and plays an imortant role in human prostate cancer associated growth signaling pathway. | Reference |
| PYCR1 | Pyrroline-5-carboxylate reductase 1 | Enzyme | AR Signaling | Pyrroline-5-carboxylate reductase 1 (PYCR1), catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate (P5C) to proline, plays a significant role in human prostate cancer through mediating the oncogenic action of androgen receptor (AR) signaling. | Reference |
| FER | Fer (fps/fes related) tyrosine kinase | Tyrosine Kinase | AR Signaling | FER tyrosine kinase functions as an important mediator in IL-6-STAT3 associated signaling and plays a crucial role in human prostate tumorigenesis through an aberrant activation of androgen receptor (AR). | Reference |
| YB1 | Y-box binding protein 1 | Transcription Factor | AR Signaling | Y-box binding protein-1 (YB-1), a pleiotropic transcription factor which is upregulated in CPRC, promote docetaxel resistance in castration resistant prostate cancer (CRPC) through interaction with androgen receptor (AR) | Reference |
| TWIST1 | Twist family bHLH transcription factor 1 | Transcription Factor | AR Signaling | TWIST1, a member of basic helix-loop-helix transcription factors, significantly contributes docetaxel resistance in castration resistant prostate cancer (CRPC) through interaction with androgen receptor (AR) | Reference |
| PIM1 | Pim-1 proto-oncogene, serine/threonine kinase | Serine/Threonine Kinase | AR Signaling | PIM1, which is overexpressed in advanced human prostate cancer, plays a role in prostate cancer cell survival through enhancement of AR transcriptional activity in a ligand-responsive manner. | Reference |