| Protein | Protein Name | Molecular Type | Feature | Evidence | Reference |
|---|
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Androgen Independence | Wnt/beta catenine mediated signaling is involved in the promotion of androgen independent prostate cancer cell growth. | Reference |
| FHL2 | Four and a half LIM domains 2 | Adaptor Protein | Androgen Independence | FHL2, an adaptor protein and a critical transcriptional coactivator, plays a very important role in activation of androgen receptor(AR) and there by promotes androgen independent prostate cancer progression. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Androgen Independence | Androgen receptor (AR) itself mediates androgen independent prostate cancer cell growth through upregulation of c-MYC oncogene. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Androgen Independence | AKT1 is involved in androgen independent prostate cancer cell prolliferation and cell adhesion, and there by mediates androgen independent prostate cancer progression. | Reference |
| BCL2 | B-cell CLL/lymphoma 2 | Adaptor Protein | Androgen Independence | BCL2, which is overexpressed in human prostate cancer, plays an important role in the development of androgen independent prostate cancer and currently BCL2 is considered as a therapeutic target in castration resistant prostate cancer. | Reference |
| VAV3 | Vav 3 guanine nucleotide exchange factor | Guanine Nucleotide Exchange Factor | Androgen Independence | VAV3, which is overexpressed in castration resistant prostate cancer, plays a very important role in androgen independent prostate cancer cell growth and cell survival through enhancement of androgen independent splice variant (AR3) activity. | Reference |
| RB1 | Retinoblastoma 1 | Transcription Regulatory Protein | Androgen Independence | Retinoblastoma1 (RB1), which is frequently inactivated during prostate cancer progression, plays a very significant role the development of androgen independent prostate cancer. | Reference |
| CXCR4 | Chemokine (C-X-C motif) receptor 4 | G protein Coupled Receptor | Androgen Independence | CXCL12/CXCR4 axis is involved in androgen independent prostate cancer progression through mediating ligand independent activation of androgen receptor (outlaw activation). | Reference |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | GTPase | Androgen Independence | RAC1 activation plays a leading role in androgen independent prostate cancer cell proliferation and ther by promotes the development of androgen independence. | Reference |
| KLK2 | kallikrein related peptidase 2 | Serine Protease | Androgen Independence | Kallikrein related peptidase 2 (KLK2) plays an important modulatory role in the transactivation of androgen receptor (AR), which enhances prostate cancer cell growth and there by promotes human prostate tumorigenesis (outlaw activation). | Reference |
| EZH2 | Enhancer of zeste 2 polycomb repressive complex 2 subunit | Transcription Regulatory Protein | Androgen Independence | Polycomb protein enhancer of zeste homolog 2 (EZH2), which is overexpressed in castration resistant human prostate cancer and plays an important role in androgen independent prostate cancer progression. | Reference |
| ADRB2 | Adrenoceptor beta 2 | G protein Coupled Receptor | Androgen Independence | Beta2-adrenergic receptor (ADRB2) plays a critical role in the regulation of androgen independent prostate cancer progression through alteration in steroid metabolism. | Reference |
| ACSL4 | Acyl-CoA synthetase long-chain family member 4 | Enzyme | Androgen Independence | Long-chain fatty acyl-CoA synthetase 4 (ACSL4) is involved in the development of androgen independent prostate cancer cell growth and there by drives castration resistance. | Reference |
| LSD1 | Lysine (K)-specific demethylase 1A | Enzyme Deacetylase | Androgen Independence | Lysine-specific demethylase 1 (LSD1) promotes androgen receptor activation in human prostate cancer cell and there by mediates androgen independent transition. | Reference |
| CSL | Chorionic somatomammotropin hormone-like 1 | Peptide Hormone | Androgen Independence | CSL plays an impotant role in the development of androgen independent prostate cancer through regulation of AKT mediated signaling and androgen receptor (AR). | Reference |
| CAV1 | Caveolin 1, caveolae protein, 22kDa | Structural Protein | Androgen Independence | Caveolin-1(CAV1), a cholesterol binding protein plays a role in androgen independent prostate cancer progression through influencing metastasis in response of hypercholesterolemia. | Reference |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | Adaptor protein | Androgen Independence | IQGAP1, a ubiquitously expressed scaffolding protein is involved in the development of androgen independent independent prostate cancer progression through driving metastasis in response of hypercholesterolemia. | Reference |
| ANGPTL2 | Angiopoietin like 2 | Secreted polypeptide | Androgen Independence | Angiopoietin like 2 (ANGPTL2), mediates a critical role in the acquisition of androgen independent prostate cancer and there by promotes prostate tumorigenesis through an autocrine and/or paracrine manner. | Reference |
| LSD1 | Lysine (K)-specific demethylase 1A | Enzyme Deacetylase | Androgen Independence | Lysine-specific demethylase 1 (LSD1) plays a critical role in the development and metastatic progression of androgen independent prostate cancer. | Reference |
| LPAR6 | Lysophosphatidic acid receptor 6 | G protein Coupled Receptor | Androgen Independence | Lysophosphatidic acid receptor 6 (LPAR6) plays a role in the development of androgen independent prostate cancer through regulation of metastatic progression. | Reference |
| PAX2 | Paired box 2 | Transcription Regulatory Protein | Androgen Independence | Paired box 2 (PAX2) is involved in androgen-independent prostate cancer cell growth through regulation of androgen receptor (AR). | Reference |
| AKT2 | v-akt murine thymoma viral oncogene homolog 2 | Serine/Threonine Kinase | Androgen Independence | AKT2 plays a role in androgen independent prostate cancer cell prolliferation through regulation of cell cycle. | Reference |
| TIP60 | K(lysine) acetyltransferase 5 | Enzyme Acyltransferase | Androgen Independence | TIP60 , an AR coactivator mediates an essential role in androgen independent prostate cancer cell proliferation through mediating androgen receptors nuclear translocation. | Reference |
| CX3CR1 | Chemokine (C-X3-C motif) receptor 1 | G protein Coupled Receptor | Androgen Independence | CX3CR1, which is highly expressed in androgen-independent prostate cancer, plays a role androgen-independent prostate cancer progression through influencing cell migration and invasion in response of hypoxia. | Reference |
| ERBB3 | Erb-b2 receptor tyrosine kinase 3 | Receptor Tyrosine Kinase | Androgen Independence | HER3, which is overexpressed in androgen independent prostate cancer and plays a significant role in androgen independent prostate cancer development through activation PI3K/AKT mediated signaling. | Reference |
| MUC1 | Mucin 1, cell surface associated | Unclassified | Androgen Independence | Mucin 1 (MUC1), a heterodimeric oncoprotein which is overexpressed in human prostate cancer, drives androgen independent prostate cancer progression through promoting androgen independent prostate cancer cell growth. | Reference |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | Tyrosine Kinase | Androgen Independence | LYN tyrosine kinase, which is highly expressed in CRPC, functions as a critical regulator of androgen receptor (AR), plays a role in androgen independent prostate cancer development. | Reference |
| SOX2 | SRY-box 2 | Transcription Factor | Androgen Independence | SOX2, a transcription factor plays a critical regulatory role in androgen independent prostate cancer cell proliferation and evasion of apoptosis, there by mediates androgen independent prostate cancer development. | Reference |
| HMGA1 | High mobility group AT-hook 1 | DNA Binding Protein | Androgen Independence | High mobility group protein AT-hook 1 (HMGA1) plays an important role in androgen independent prostate cancer cell growth and transition from androgen sensitive to androgen independent prostate cancer development. | Reference |
| FN14 | Tumor necrosis factor receptor superfamily member 12A | Cell Surface Receptor | Androgen Independence | Fibroblast growth factor-inducible 14 (FN14), a transmembrane receptor for its ligand TWEAK, plays a role in the development of androgen independent prostate cancer through effecting cell invasion, migration and proliferation. | Reference |