Human Prostrate Cancer Hallmarks Map

Cancer Hallmark > Self-Sufficiency in Growth Signal

Prostrate Cancer Self-Sufficiency in Growth Signal

Hallmark Underlying Feature
Molecular Connectivity Map
Oncogenic Signalling Pathway Map
Oncogenic Functional Connectivity Map (Pathway based)
Inter Hallmark Functional Connectivity Map

Intrinsic components of Prostrate Cancer hallmark event Self-Sufficiency in Growth Signal

Protein	Protein Name	Molecular Type	Feature	Evidence	Reference
SP1	Sp1 transcription factor	Transcription Factor	Cell Proliferation	SP1 is associated with prostate cancer cell proliferation.	Reference
STAT5B	Signal transducer and activator of transcription 5B	Transcription Factor	Cell Survival	STAT5B is associated with prostate cancer cell survival.	Reference
STAT5B	Signal transducer and activator of transcription 5B	Transcription Factor	Cell Growth	Promotes cell growth in androgen dependent & independent prostate cancer cell line.	Reference
E2F1	E2F transcription factor 1	Transcription Factor	Cell Survival	E2F1 is involved in prostate cancer cell survival through NF-kappaB dependent induction of EGR1 transcription factor.	Reference
E2F1	E2F transcription factor 1	Transcription Factor	Cell Growth	E2F1 is involved in prostate cancer cell growth and this activity is regulated by tristetraprolin (TTP).	Reference
MYC	V-myc avian myelocytomatosis viral oncogene homolog	Transcription Factor	Cell Growth	c-MYC is involved in anchorage independent prostate cancer cell growth through regulating ezrin protein expression in an androgen dependent way.	Reference
MYC	V-myc avian myelocytomatosis viral oncogene homolog	Transcription Factor	Cell Proliferation	c-MYC is involved in prostate cancer cell proliferation as targeted reduction of c-MYC results in suppression of cell proliferation in prostate cancer cell line LNCaP.	Reference
SMAD4	SMAD family member 4	Transcription Factor	Cell Proliferation	SMAD4 inactivation accelarates prostate cancer cell proliferation	Reference
RUNX2	Runt-related transcription factor 2	Transcription Factor	Cell Growth	RUNX2 is involved in prostate cancer cell growth in an androgen responsive ways.	Reference
E2F2	E2F transcription factor 2	Transcription Factor	Cell Proliferation	E2F2 is involved in prostate cancer cell proliferation as microRNA let-7a targets E2F2 and inhibits proliferation of human prostate cancer cell in vitro and in vivo.	Reference
LPXN	Leupaxin	Adaptor Protein	Cell Proliferation	Leupaxin(LPXN) knock down significantly reduces proliferation rate of LNCaP cells.	Reference
FOXO1	Forkhead box O1	Transcription Factor	Cell Survival	Its inactivation via CDK1 mediated phosphorylation enhances cell survival in androgen dependent prostate cancer cell line.	Reference
FOXO1	Forkhead box O1	Transcription Factor	Cell Proliferation	CDK1 play an important role in prostate cancer cell proliferation by phosphorylation and inhibition of tumour suppressor gene FOXO1.	Reference
STAT3	Signal transducer and activator of transcription 3 (acute-phase response factor)	Transcription Factor	Cell Growth	STAT3 mediates IL-6 induced growth inhibition in androgen dependent prostate cancer cells.	Reference
STAT3	Signal transducer and activator of transcription 3 (acute-phase response factor)	Transcription Factor	Cell Growth	STAT3 is associated with prostate cancer cell growth as inhibition of STAT3 activity results in suppression of cell growth in DU145 prostate cancer cells.	Reference
SMAD3	SMAD family member 3	Transcription Regulatory Protein	Cell Growth	SMAD3 play a critical role in prostate cancer cell growth in androgen-independent PC-3MM2 prostate cancer cells	Reference
COMMD1	Copper metabolism (Murr1) domain containing 1	Unclassified	Cell Survival	Secretory clusterin (sCLU) degrades COMMD1 and promotes prostate cancer cell survival through activation of canonical NF-kappaB pathway.	Reference
BCL2	B-cell CLL/lymphoma 2	Adaptor Protein	Cell Survival	Antisense mediated downregulation of BCL2 inhibits prostate cancer cell survival.	Reference
BCL2	B-cell CLL/lymphoma 2	Adaptor Protein	Cell Survival	BCL2 is involved in prostate cancer cell survival by the regulation of Ceramide and Arachidonate signaling pathway.	Reference
RAC1	Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	GTPase	Cell Survival	RAC1 is associated with prostate cancer cell survival through AKT mediated pathway.	Reference
RAC1	Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	GTPase	Cell Proliferation	RAC1 play an important role in androgen independent prostate cancer cell proliferation, supported by both in vitro and in vivo experiments	Reference
KRAS	Kirsten rat sarcoma viral oncogene homolog	GTPase	Cell Proliferation	KRAS is involved in prostate cancer cell proliferation as miR-143 targets KRAS suppressed prostate cancer cell proliferation.	Reference
PDE4D	Phosphodiesterase 4D, cAMP-specific	Enzyme Phosphodiesterase	Cell Growth	PDE4D is involved in prostate cancer cell growth as knock down of this gene reduced the growth rate of prostate cancer cells in vivo.	Reference
PDE4D	Phosphodiesterase 4D, cAMP-specific	Enzyme Phosphodiesterase	Cell Proliferation	PDE4D is associated with prostate cancer as a proliferation promoting factor as knockdown of this gene suppressed the the proliferation rate of prostate cancer xenograft in vivo.	Reference
SOCS3	Suppressor of cytokine signaling 3	Adaptor Protein	Cell Survival	SOCS3 plays an important role in castration resistant prostate cancer cell survival.	Reference
DAB2	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	Adaptor Protein	Cell Proliferation	PKC mediated phosphorylation of DAB2 protein regulates its inhibitory function in cell proliferation	Reference
DAB2	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	Adaptor Protein	Cell Growth	DAB2 mediated signaling is involved in the modulation of androgen mediated cell growth in both normal and malignant prostate epithelial cells	Reference
BAK1	BCL2-antagonist/killer 1	Adaptor Protein	Cell Growth	miR-125b mediated suppression of BAK1 results in androgen independent growth of prostate cancer cells	Reference
BIN1	Bridging integrator 1	Adaptor Protein	Cell Growth	Functions as a prostate cancer cell growth suppressor.	Reference
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	Adaptor Protein	Cell Growth	Plays a role steroid hormone stimulated prostate cancer cell growth.	Reference
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	Adaptor Protein	Cell Proliferation	SHC1(p52SHC) is involved in androgen stimulated cell proliferation in LNCaP prostate cancer cells.	Reference
YWHAZ	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta	Adaptor Protein	Cell Survival	14-3-3 zeta (YWHAZ) interacts with AR and promotes prostate cancer cell survival in an androgen responsive way	Reference
CRKL	v-crk avian sarcoma virus CT10 oncogene homolog-like	Adaptor Protein	Cell Growth	CRKL interacts with androgen receptor (AR) and use an alternative growth factor signaling in prostate cancer	Reference
DVL2	Dishevelled segment polarity protein 2	Adaptor Protein	Cell Growth	Enhances prostate cancer growth potential by up regulating AR expression in androgen dependent prostate cancer cell line.	Reference
FHL2	Four and a half LIM domains 2	Adaptor Protein	Cell Growth	FHL2 is associated with constitutive activation of AR-mediated growth signals in prostate cancer	Reference
SOCS1	Suppressor of cytokine signaling 1	Adaptor Protein	Cell Growth	SOCS1 acts as a negative growth regulator in prostate cancer	Reference
CFLAR	CASP8 and FADD-like apoptosis regulator	Adaptor Protein	Cell Survival	Androgen recptor regulates CFLAR and effects prostate cancer cell survival	Reference
BIRC6	Baculoviral IAP repeat containing 6	Adaptor Protein	Cell Survival	Play a role in prostate cancer cell survival , treatment resistance & castration resistance in androgen dependent and independent prostate cancer cell lines.	Reference
BCL2L1	BCL2-like 1	Adaptor Protein	Cell Survival	BCL2L1 is involved in prostate cancer cell survival through interaction with proapoptotic BAK	Reference
BCL2L1	BCL2-like 1	Adaptor Protein	Cell Survival	BCL2L1 is involved in prostate tumour cell survival by AR induced Integrin alpha6beta1 mediated manner	Reference
FADD	Fas (TNFRSF6)-associated via death domain	Adaptor Protein	Cell Survival	Strongly influences prostate cancer cell survival by modulating hTERT expression and telomerase activity in androgen independent prostate cancer cell line.	Reference
TGFBR2	Transforming growth factor, beta receptor II	Receptor Serine/threonine Kinase	Cell Proliferation	During endothelial & perineural invasion TGF beta mediated enhanced secretion of CAV1 into the tumor microenvironment causes marked increase of proliferative activity in prostate cancer cell	Reference
BMPR2	Bone morphogenetic protein receptor, type II (serine/threonine kinase)	Receptor Serine/threonine Kinase	Cell Survival	BMPR2 promotes prostate cancer cell survival	Reference
BMPR2	Bone morphogenetic protein receptor, type II (serine/threonine kinase)	Receptor Serine/threonine Kinase	Cell Growth	Knock down of BMPR2 receptor enhance in vitro cell growth in prostate cancer PC3 cell.	Reference
IGF1R	Insulin-like growth factor 1 receptor	Receptor Tyrosine Kinase	Cell Survival	Mediates prostate cancer cell survival through Akt; involved in suppression of apoptosis; mediates prosurvival signaling by neuroendocrine derived peptides.	Reference
IGF1R	Insulin-like growth factor 1 receptor	Receptor Tyrosine Kinase	Cell Growth	IGF1R is transcriptionally regualted by transcription factor Early Growth Response-1 (EGR-1) and is involved in prostate cancer cell growth.	Reference
IGF1R	Insulin-like growth factor 1 receptor	Receptor Tyrosine Kinase	Cell Growth	IGF-IR promotes prostate cancer growth by stabilizing alpha5beta1 integrin protein levels.	Reference
IGF1R	Insulin-like growth factor 1 receptor	Receptor Tyrosine Kinase	Cell Proliferation	IGF1R is involved in prostate cancer cell survival as siRNA mediated silencing of IGF1R results in reduction of cell survival in prostate cancer PC-3 cells.	Reference
EPHB2	EPH receptor B2	Receptor Tyrosine Kinase	Cell Growth	EPHB2 play an important roles in Prostate cancer cell growth as its transfection in DU 145 cells which lack the EPHB2 suppresses clonogenic growth.	Reference
PDGFRB	Platelet-derived growth factor receptor, beta polypeptide	Receptor Tyrosine Kinase	Cell Survival	PDGFRB-MCL1 mediated survival signaling play an important role in prostate cancer cell survival.	Reference
PDGFRB	Platelet-derived growth factor receptor, beta polypeptide	Receptor Tyrosine Kinase	Cell Growth	PDGFR is involved in prostate cancer cell growth as siRNA mediated silencing of PDGFRB in mouse model results in reduction of cell growth in prostate cancer.	Reference
AXL	AXL receptor tyrosine kinase	Receptor Tyrosine Kinase	Cell Survival	AXL is involved in prostate cancer cell survival as suppression of AXL by small interfering RNA suppress prostate cancer cell survival.	Reference
AXL	AXL receptor tyrosine kinase	Receptor Tyrosine Kinase	Cell Growth	AXL is an important regulator of prostate cancer cell growth as inhibition of AXL gene expression results in suppression of prostate cancer cell growth.	Reference
AXL	AXL receptor tyrosine kinase	Receptor Tyrosine Kinase	Cell Proliferation	AXL is an important regulator of prostate cancer cell proliferation as inhibition of AXL gene expression results in suppression of prostate cancer cell proliferation.	Reference
EGFR	Epidermal growth factor receptor	Receptor Tyrosine Kinase	Cell Growth	EGFR is associated with prostate cancer cell growth through both paracrine and autocrine manner.	Reference
EGFR	Epidermal growth factor receptor	Receptor Tyrosine Kinase	Cell Proliferation	EGFR is involved in prostate cancer cell proliferation in an ADAM17 induced and EGFR/PI3K/AKT pathway.	Reference
EGFR	Epidermal growth factor receptor	Receptor Tyrosine Kinase	Cell Proliferation	EGFR plays an important role in prostate cancer cell proliferation as microRNA targeting EGFR suppressed cell proliferation in androgen insensitive cell line PC3 and DU145.	Reference
NTRK1	Neurotrophic tyrosine kinase, receptor, type 1	Receptor Tyrosine Kinase	Cell Growth	NTRK1 is involved in prostate cancer epithelial cell growth.	Reference
RET	Ret proto-oncogene	Receptor Tyrosine Kinase	Cell Growth	RET is associated in the growth of both benign and neoplastic prostate epithelial cells.	Reference
FGFR1	Fibroblast growth factor receptor 1	Receptor Tyrosine Kinase	Cell Growth	Androgen insensitive prostate cancer in vivo cell growth is mediated by FGF7 and its receptor FGFR1 under condition of androgen ablation.	Reference
FGFR1	Fibroblast growth factor receptor 1	Receptor Tyrosine Kinase	Cell Proliferation	FGF2 & its receptor FGFR1 is involved in prostate cancer epithelial cell proliferation.	Reference
MET	Met proto-oncogene	Receptor Tyrosine Kinase	Cell Growth	HGF and c-MET is involved in androgen independent prostate cancer cell growth in CWR22R prostate cancer cell line.	Reference
ERBB2	V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	Receptor Tyrosine Kinase	Cell Growth	Mediates prostate cancer cell growth regulation in androgen dependent prostate cancer cell line; phosphorylated by prostatic acid phosphatase (cPAcP); involved in castration resistance.	Reference
ERBB2	V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	Receptor Tyrosine Kinase	Cell Proliferation	Both EGFR and ERBB2 is involved in prostate cancer cell proliferation.	Reference
PDGFRA	Platelet-derived growth factor receptor, alpha polypeptide	Receptor Tyrosine Kinase	Cell Survival	PDGFRA is implicated in prostate cancer cell survival.	Reference
PRLR	Prolactin receptor	Receptor Tyrosine Kinase	Cell Survival	PRLR mediated signaling provides critical survival advantages for prostate cancer	Reference
PRLR	Prolactin receptor	Receptor Tyrosine Kinase	Cell Growth	Prolactin enhances prostate cancer cell growth via PRLR-JAK2 mediated signaling	Reference
PRLR	Prolactin receptor	Receptor Tyrosine Kinase	Cell Proliferation	Inhibition of prolactin receptor by endocannabinoids results in suppression of prostate cancer cell proliferation	Reference
IL6ST	Interleukin 6 signal transducer	Cytokine Receptor	Cell Growth	IL6 enhance prostate cancer cell growth through IL6ST(GP130)-JAK2-STAT3 mediated signaling pathway in LNCaP human prostate cancer cells.	Reference
IL6ST	Interleukin 6 signal transducer	Cytokine Receptor	Cell Growth	IL6 is an autocrine growth factor mediates its effects on prostate cancer cell growth through JAK-STAT signalin	Reference
IL6ST	Interleukin 6 signal transducer	Cytokine Receptor	Cell Growth	Prostaglandin E2 enhances prostate cancer cell growth via activation of IL6/IL6ST/STAT3 signaling	Reference
CXCR4	Chemokine (C-X-C motif) receptor 4	G protein Coupled Receptor	Cell Growth	CXCR4 antagonists inhibits tumour growth in PC-3 xenograft model by suppressing CXCR4 mediated signaling	Reference
CXCR4	Chemokine (C-X-C motif) receptor 4	G protein Coupled Receptor	Cell Proliferation	CXCR4 mediated signaling is involved in prostate cancer epithelial cell proliferation	Reference
GHR	Growth hormone receptor	Cell Surface Receptor	Cell Survival	Autocrine growth hormone is involved in prostate cancer cell survival through alteration of GHR trafficking in androgen-dependent LNCaP cells.	Reference
GHR	Growth hormone receptor	Cell Surface Receptor	Cell Growth	Growth hormone receptor(GHR) shows an important role in prostate cancer cell growth and in present in the epithelial cells of the tumour acini.	Reference
GHR	Growth hormone receptor	Cell Surface Receptor	Cell Proliferation	Growth hormone receptor(GHR) is involved in prostate cancer cell proliferation in androgen-dependent LNCaP cells.	Reference
PHB	Prohibitin	Adaptor Protein	Cell Growth	Prohibitin(PHB) is down regulated by androgen and enhances androgen stimulated growth and cell cycle entry in prostate cancer.	Reference
NGFR	Nerve growth factor receptor	Cell Surface Receptor	Cell Survival	NGFR(p75NTR) and its ligand NGFR is involved in pro survival signaling in prostate cancer.	Reference
EPOR	Erythropoietin receptor	Cell Surface Receptor	Cell Growth	Erythropoietin -Erythropoietin receptor(EPOR) system is involved in human prostate cancer growth regulation through STAT5B phosphorylation.	Reference
AR	Androgen receptor	Nuclear Receptor	Cell Survival	AR transcriptionally activate 14-3-3zeta and through its action enhances prostate cancer cell survial & proliferation	Reference
AR	Androgen receptor	Nuclear Receptor	Cell Growth	Ar is involved in prostate cancer cell growth via AMPK-PGC-1alpha signaling cascade, a known homeostatic mechanism, to increase prostate cancer cell growth	Reference
AR	Androgen receptor	Nuclear Receptor	Cell Growth	Regulates prostate cancer cell growth through a metabolic switch; promotes growth through ELK1; enhance cell growth through a ternary membrane associated complex with c-Src.	Reference
AR	Androgen receptor	Nuclear Receptor	Cell Proliferation	Cell proliferation is linked to ribosome biogenesis which is stimulated by AR and Estrogen receptor signaling in prostate cancer	Reference
VAV3	Vav 3 guanine nucleotide exchange factor	Guanine Nucleotide Exchange Factor	Cell Growth	VAV3 is involved in prostate cancer cell growth in LNCaP prostate cancer cell line.	Reference
ST7	Suppression of tumorigenicity 7	Cell Cycle Control Protein	Cell Growth	ST7 is involved in influencing the prostate cancer cell growth as ST7 suppressed the prostate cancer cell growth of PC-3 prostate cancer cells inoculated subcutaneously into severe combined immunodeficient(SCID) mice.	Reference
CDKN1B	Cyclin-dependent kinase inhibitor 1B (p27, Kip1)	Cell Cycle Control Protein	Cell Proliferation	CDKN1B(p27) is involved in androgen independent prostate cancer cell proliferation as SOX2 targets p27 and regulate prostate cancer cell proliferation.	Reference
CDKN1B	Cyclin-dependent kinase inhibitor 1B (p27, Kip1)	Cell Cycle Control Protein	Cell Proliferation	Inhibition of FOXO3a-mediated activation of the p27 gene by the high aberrant expression of c-Myc in many tumor cells likely contributes to their uncontrolled proliferation and invasive phenotype.	Reference
CDKN1A	Cyclin-dependent kinase inhibitor 1A (p21, Cip1)	Cell Cycle Control Protein	Cell Growth	CDKN1A(p21) is involved in prostate cancer cell growth as a downstream effector of PI3K-Akt cell growth survival pathway.	Reference
CDKN1A	Cyclin-dependent kinase inhibitor 1A (p21, Cip1)	Cell Cycle Control Protein	Cell Growth	CDKN1A(p21) is involved in prostate cancer cell growth as Naftopidil, a selective alpha-1 adrenoceptor antagonist targets p21 inhibits the growth of PC-3 cells.	Reference
FRS2	Fibroblast growth factor receptor substrate 2	Adaptor Protein	Cell Proliferation	FRS2 is involved in prostate cancer cell proliferation in a FGF-FGFR dependent signaling in DU145 cells.	Reference
CEACAM1	Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	Adhesion Molecule	Cell Growth	CEACAM1 play a role in growth suppression of prostate cancer cells.	Reference
ITGB4	Integrin, beta 4	Adhesion Molecule	Cell Proliferation	(ITGB4)beta4 integrin enhance human prostate cancer cell proliferation by amplifying receptor tyrosine kinase mediated signaling.	Reference
CTNNB1	Catenin (cadherin-associated protein), beta 1, 88kDa	Adhesion Molecule	Cell Survival	Play a role in osteopontin mediated prostate cancer cell survival in androgen dependent & independent prostate cancer cell line.	Reference
CTNNB1	Catenin (cadherin-associated protein), beta 1, 88kDa	Adhesion Molecule	Cell Growth	Beta catenine(CTNNB1) is involved in prostate cancer cell growth as inhibitor targeting beta catenine suppressed prostate cancer cell growth.	Reference
CTNNB1	Catenin (cadherin-associated protein), beta 1, 88kDa	Adhesion Molecule	Cell Proliferation	Beta catenine(CTNNB1) is associated with prostate cancer cell proliferation as lupeol targets beta catenine and inhibits proliferation of prostate cancer cell.	Reference
MAPK14	Mitogen-activated protein kinase 14	Serine/Threonine Kinase	Cell Growth	MAPK14(p38 alpha) is associated with aggressive growth of prostate cancer cell in LNCaP prostate cancer cell line .	Reference
MAPK3	Mitogen-activated protein kinase 3	Serine/Threonine Kinase	Cell Survival	MAPK3(ERK1) is associated with prostate cancer cell survival through PKCepsilon/PKD3 pathway.	Reference
MAPK3	Mitogen-activated protein kinase 3	Serine/Threonine Kinase	Cell Growth	MAPK3(ERK1) is associated with prostate cancer cell growth through PKCepsilon/PKD3 pathway.	Reference
MAPK3	Mitogen-activated protein kinase 3	Serine/Threonine Kinase	Cell Proliferation	MAPK3(ERK1) activation through PI3K mediated signaling play an important role in prostate cancer cell proliferation.	Reference
RAF1	V-raf-1 murine leukemia viral oncogene homolog 1	Serine/Threonine Kinase	Cell Growth	RAF1 play an important role in growth suppresion of prostate cancer through RAF/MEK/MAPK pathway activation.	Reference
AKT1	V-akt murine thymoma viral oncogene homolog 1	Serine/Threonine Kinase	Cell Survival	AKT1 is involved in prostate cancer cell survival in a cholesterol responsive way.	Reference
AKT1	V-akt murine thymoma viral oncogene homolog 1	Serine/Threonine Kinase	Cell Growth	AKT1 is involved in prostate tumour cell growth as a downstream effector of CXCL12/CXCR4 mediated signaling in DU145 prostate cancer cell line.	Reference
AKT1	V-akt murine thymoma viral oncogene homolog 1	Serine/Threonine Kinase	Cell Proliferation	AKT1 play an important role in prostate cancer cell proliferation through EGF-EGFR & ERBB2 mediated signaling.	Reference
AKT1	V-akt murine thymoma viral oncogene homolog 1	Serine/Threonine Kinase	Cell Proliferation	AKT1 play an important role in prostate cancer cell proliferation through GAS6-AXL mediated signaling.	Reference
PRKCE	Protein kinase C, epsilon	Serine/Threonine Kinase	Cell Survival	PRKCE is associate with prostate cancer cell survival by interacting with BAX in LNCaP cells.	Reference
PRKCE	Protein kinase C, epsilon	Serine/Threonine Kinase	Cell Growth	PRKCE is associated with prostate cancer epithelial cell growth.	Reference
FRS3	Fibroblast growth factor receptor substrate 3	Adaptor Protein	Cell Proliferation	FRS3 is involved in prostate cancer cell proliferation in a FGF-FGFR dependent signaling in DU145 cells.	Reference
PRKCD	Protein kinase C, delta	Serine/Threonine Kinase	Cell Survival	PRKCD is involved in prostate cancer cell survival in an Androgen receptor(AR) dependent manner in both hormone sensitive and castration resistant prostate cancer.	Reference
PRKCD	Protein kinase C, delta	Serine/Threonine Kinase	Cell Growth	PRKCD is involved in prostate cancer cell growth in an Androgen receptor(AR) dependent manner in both hormone sensitive and castration resistant prostate cancer.	Reference
PLK1	Polo-like kinase 1	Serine/Threonine Kinase	Cell Proliferation	PLK1 plays an important role during mitotic entry of prostate cancer cell proliferation.	Reference
CDK5	Cyclin-dependent kinase 5	Serine/Threonine Kinase	Cell Growth	CDK5 plays a role in prostate cancer cell growth by regulating androgen receptor stability.	Reference
GSK3B	Glycogen synthase kinase 3 beta	Serine/Threonine Kinase	Cell Growth	GSK3B is involved in both androgen dependent and androgen independent prostate cancer cell growth through GSK-3/AR signaling axis.	Reference
JAK2	Janus kinase 2	Tyrosine Kinase	Cell Growth	JAK2 is involved in both primary and castration resistant prostate cancer cell growth through JAK2-STAT5 mediated signaling as JAK2 inhibitor suppress both types of prostate cancer cell growth.	Reference
FYN	FYN oncogene related to SRC, FGR, YES	Tyrosine Kinase	Cell Growth	FYN play an important role in prostate cancer cell growth mediated by HGF/MET signaling axis.	Reference
FYN	FYN oncogene related to SRC, FGR, YES	Tyrosine Kinase	Cell Proliferation	FYN is involved in the prostate cancer cell proliferation through both integrin and receptor tyrosine kinase mediated manner.	Reference
NRBP1	Nuclear receptor binding protein 1	Adaptor Protein	Cell Growth	NRBP1 is upregulated during prostate cancer pathogenesis and involved in prostate cancer cell growth.	Reference
SRC	V-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog	Tyrosine Kinase	Cell Growth	SRC play an important role in prostate cancer cell growth through Src/FAK/Rho GTPase signaling pathway.	Reference
PXN	Paxillin	Cytoskeletal Associated Protein	Cell Proliferation	Paxillin(PXN) play an important role in both androgen and growth factor mediated cell proliferation by modulating ERK mediated signaling in both castration sensitive and castration resistant prostate cancer.	Reference
ADAM12	ADAM metallopeptidase domain 12	Metallo Protease	Cell Growth	ADAM12 is involved in tuour growth and development in the mouse model of prostate cancer.	Reference
PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Lipid Kinase	Cell Survival	Involved in cell survival through AKT activation in both androgen dependent & independent prostate cancer cell line.	Reference
PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Lipid Kinase	Cell Growth	PIK3CB is involved in prostate cancer cell growth through PIK3 pathway activation in PTEN deficient prostate tumour xenograft model.	Reference
PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Lipid Kinase	Cell Proliferation	PIK3CB is involved in prostate cancer abnormal cell proliferation through PIK3 pathway activation in PTEN deficient prostate tumour xenograft model.	Reference
PRKCE	Protein kinase C, epsilon	Serine/Threonine Kinase	Cell Survival	It is involved in prostate cancer cell survival through integrin mediated Akt/PKB activation.	Reference
CTNNB1	Catenin (cadherin-associated protein), beta 1, 88kDa	Adhesion Molecule	Cell Survival	Disruption of reciprocal balance between the beta-cat/Tcf and the beta-cat/AR pathways results in prostate cancer cell survival.	Reference
AKT1	V-akt murine thymoma viral oncogene homolog 1	Serine/Threonine Kinase	Cell Survival	It mediates prostate cancer cell survival in response of IGF1R.	Reference
PDGFRA	Platelet-derived growth factor receptor, alpha polypeptide	Receptor Tyrosine Kinase	Cell Survival	Mediates prostate cancer cell survival through Akt/PKB manner in bone metastatic prostate cancer.	Reference
IGF1R	Insulin-like growth factor 1 receptor	Receptor Tyrosine Kinase	Cell Survival	Mediates prostate cancer prosurvival signaling by neuroendocrine derived peptides.	Reference
CTNNB1	Catenin (cadherin-associated protein), beta 1, 88kDa	Adhesion Molecule	Cell Proliferation	Involved in prostate cancer cell proliferation in androgen independent PC-3 and DU-145 prostate cancer cell line.	Reference
AR	Androgen receptor	Nuclear Receptor	Cell Growth	Mediates PAK6 activation and associated with prostate cancer cell growth.	Reference
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	Adaptor Protein	Cell Growth	Involved in non genomic androgen mediated prostate cancer cell growth regulation.	Reference
MYC	V-myc avian myelocytomatosis viral oncogene homolog	Transcription Factor	Cell Growth	Mediates prostate cancer cell growth regulation through interaction with ROCK in androgen independent prostate cancer cell line.	Reference
RUNX2	Runt-related transcription factor 2	Transcription Factor	Cell Growth	Nitric oxide regulates RUNX2 (a transcription factor), which is highly expressed in human prostate tumour and plays a role in prostate cancer cell growth.	Reference
PIAS1	Protein inhibitor of activated STAT, 1	Cell Cycle Control Protein	Cell Survival	PIAS1, which is overexpressed in human prostate tumour plays a role in prostate cancer cell survival.	Reference
FOXO3	Forkhead box O3	Transcription Factor	Cell Proliferation	FOXO3, a member of the forkhead transcriptional factor family, is repressed by tumour suppressor MiR-592 and thereby contributes to prostate cancer cell proliferation through upregulation of cyclin D1 and down regulation of p21.	Reference
HEC1	NDC80 kinetochore complex component	Cell Cycle Control Protein	Cell Proliferation	HEC1, a kinetochore complex component, which is overexpressed in human prostate cancer and plays an important role in prostate cancer cell proliferation through regulating long non-coding RNA BX647187.	Reference
PSGR	Prostate	G protein Coupled Receptor	Cell Proliferation	Prostate specific G protein coupled receptor (PSGR) promotes human prostate cancer cell proliferation through activation of PI3K, MAPK and SRC mediated signaling.	Reference
PIN1	Peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Enzyme	Cell Proliferation	Peptidyl-prolyl isomerase PIN1 plays a role in human prostate cancer associated cell proliferation through activation of WNT/beta-catenine mediated signaling.	Reference
CX3CL1	Chemokine (C-X3-C motif) ligand 1	Chemokine	Cell Proliferation	Fractalkine (CX3CL1), a membrane?bound chemokine, is involved in human prostate cancer cell proliferation through mediating G1-S phase cell cycle transition in an hypoxia responsive manner.	Reference
ACSL4	Acyl-CoA synthetase long-chain family member 4	Enzyme	Cell Growth	Long-chain fatty acyl-CoA synthetase 4 (ACSL4) critically mediates human prostate cancer cell growth through activation of several signaling components including AKT, LSD1 and CTNNB1.	Reference
CHEK2	Checkpoint kinase 2	Serine/Threonine Kinase	Cell Growth	Checkpoint kinase 2 (CHK2), a critical negative growth regulator which is lost during prostate cancer progression to castration resistance, plays a very significant role in prostate cancer cell growth.	Reference
TOP2A	Topoisomerase (DNA) II alpha	Enzyme	Cell Growth	DNA topoisomerase 2 alpha (TOP2A), overexpressed in advanced human prostate cancer, plays a role in prostate cancer cell growth through activation of androgen receptor (AR) mediated signaling.	Reference
MAPK1	Mitogen-activated protein kinase 1	Serine/Threonine Kinase	Cell Growth	MAPK1 play a very important role in human prostate cancer cell growth as its regulator MiR-378 is significantly downregulated during prostate cancer development .	Reference
BTK	Bruton agammaglobulinemia tyrosine kinase	Tyrosine Kinase	Cell Survival	Bruton's tyrosine kinase (BTK), a non receptor tyrosine kinase plays a role in human prostate cancer cell survival.	Reference
GSTP1	Glutathione S-transferase pi 1	Enzyme	Cell Survival	Glutathione S-transferase pi 1 (GSTP1), which is epigenetically inactivated during transformation from normal prostatic epithelium to adenocarcinoma of the prostate, plays a role in human ovarian cancer cell survival.	Reference
JMJD1A	Lysine (K)-specific demethylase 3A	Unclassified	Cell Survival	Histone demethylase JMJD1A plays a role in human prostate cancer cell survival through regulating c-MYC expression at both transcriptional and post-transcriptional level.	Reference
JMJD1A	Lysine (K)-specific demethylase 3A	Unclassified	Cell Proliferation	Histone demethylase JMJD1A plays a role in human prostate cancer cell proliferation through regulating c-MYC expression at both transcriptional and post-transcriptional level.	Reference
CUL1	Cullin 1	Ubiquitin proteasome system protein	Cell Proliferation	Cullin-1 (CUL1), which is highly expressed in human prostate cancer, is involved in prostate cancer associated cell proliferation through regulation of cell cycle.	Reference
DAXX	Death-domain associated protein	Adaptor protein	Cell Survival	DAXX, an adaptor protein plays a very important role in prostate cancer cell survival through suppression of autophagy.	Reference
HAMP	Hepcidin antimicrobial peptide	Unclassified	Cell Survival	Hepcidin (HAMP), a central iron regulator which is highly expressed in human prostate cancer cell, plays a role in prostate cancer cell survival.	Reference
HAMP	Hepcidin antimicrobial peptide	Unclassified	Cell Growth	Hepcidin (HAMP), a central iron regulator which is highly expressed in human prostate cancer cell, plays a role in prostate cancer cell growth.	Reference
FGF19	Fibroblast growth factor 19	Growth Factor	Cell Proliferation	FGF19, highly expressed in human prostate cancer, plays a role in prostate cancer cell proliferation.	Reference
TLR4	Toll-like receptor 4	Cell Surface Receptor	Cell Survival	Toll-like receptor-4 (TLR4) is involved in human prostate cancer cell survival.	Reference
ARR2	Arrestin, beta 2	Adaptor protein	Cell Survival	Beta arrestin2 (ARR2), a ubiquitous scaffolding/adaptor protein, plays a role in castration resistant prostate cancer (CRPC) associated cell survival through downregulation of FOXO1 activity and expression.	Reference
ARR2	Arrestin, beta 2	Adaptor protein	Cell Proliferation	Beta arrestin2 (ARR2), a ubiquitous scaffolding/adaptor protein, plays a role in castration resistant prostate cancer (CRPC) associated cell proliferation through downregulation of FOXO1 activity and expression.	Reference
EFEMP1	EGF containing fibulin-like extracellular matrix protein 1	Extracellular Matrix Protein	Cell Proliferation	EFEMP1 inactivation through promoter methylation, plays a role in human prostate cancer associated cell proliferation.	Reference
TCTN1	Tectonic family member 1	Unclassified	Cell Growth	TCTN1, which is involved in human embryonic development, plays a role in human prostate cancer associated cell growth.	Reference
UBE2T	Ubiquitin conjugating enzyme E2T	Ubiquitin proteasome system protein	Cell Proliferation	Ubiquitin-conjugating enzyme E2T (UBE2T), which is highly expressed in human prostate cancer, plays a role in human prostate cancer associated cell proliferation.	Reference
YAP1	Yes associated protein 1	Transcription Regulatory Protein	Cell Growth	Yes-associated protein (YAP), a crucial effector of the hippo tumor suppressor pathway, plays a role in the regulation of human prostate cancer associated cell growth and there by mediates castration resistance.	Reference
RAP1A	RAP1A, member of RAS oncogene family	GTPase	Cell Proliferation	RAP1A, which is upregulated in human prostate cancer, plays a role in prostate cancer associated cell proliferation as its critical negative regulator MiR-203 is significantly downregulated in human prostate cancer.	Reference