| Protein | Protein Name | Molecular Type | Feature | Evidence | Reference |
|---|
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | Inflammation | STAT3 functions as an important regulator of pro carcinogenic prostatic inflammation. | Reference |
| NOD1 | Nucleotide-binding oligomerization domain containing 1 | Adaptor Protein | Inflammation pathway | NOD1 is involved in innate immune response by activation of NF-kapaB and associated with prostate cancer development | Reference |
| PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | Adaptor Protein | Inflammation pathway | It is implicated in prostate cancer inflammatory pathway and its genetic polymorphism has been detected in Caucasian population. | Reference |
| MET | Met proto-oncogene | Receptor Tyrosine Kinase | Inflammation pathway | c-MET is associated with prostate cancer inflammation. | Reference |
| ERBB2 | V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | Receptor Tyrosine Kinase | Inflammation pathway | ERBB2 regulate the constitutive activation of NF-kappaB in PC-3 prostate cancer cells. | Reference |
| IL6ST | Interleukin 6 signal transducer | Cytokine Receptor | Inflammation pathway | IL6ST is an inflammation pathway gene and is linked to prostate cancer inflammation. | Reference |
| IL6ST | Interleukin 6 signal transducer | Cytokine Receptor | Inflammation | It is involved in prostate cancer inflammation and its genetic polymorphism has been detected in Caucasian population. | Reference |
| CXCR4 | Chemokine (C-X-C motif) receptor 4 | G protein Coupled Receptor | Hypoxia | CXCR4/SDF-1alpha is involved in reactive oxygen species(ROS) generation during prostate tumorigenesis through NADPH oxidase (NOX) family of enzymes | Reference |
| AR | Androgen receptor | Nuclear Receptor | Inflammation | Modulation of AR-CCL4-STAT3 axis by infiltrating macrophage play an important role in prostate tumour inflammation. | Reference |
| MED1 | Mediator complex subunit 1 | Transcription Regulatory Protein | Inflammation | It is a coactivator of AR and is overexpressed in prostate cancer cell line and clinical prostate tumours. It promoptes number of important genes involved in prostate cancer inflammation. | Reference |
| HIF1A | Hypoxia inducible factor 1, alpha subunit | Transcription Factor | Inflammation | HIF1A plays a significant role in human prostate cancer related inflammation through NF-kB activation. | Reference |
| CTNND2 | Catenin delta 2 | Adhesion Molecule | Inflammation | Loss of TIMP3 plays a role in prostate cancer related inflammation as supported by a mouse model. | Reference |
| EGR3 | Early growth response 3 | Transcription Factor | Inflammation | EGR3 (Early Growth Response 3) is involved in prostate cancer associated inflammation through regulating expression of pro-inflammatory cytokines IL8 and IL6. | Reference |