| Protein | Protein Name | Molecular Type | Feature | Evidence | Reference |
|---|
| WT1 | Wilms tumor 1 | Transcription Factor | Angiogenesis | Wilm's tumour gene (WT1) is involved in prostate cancer angiogenesis through transcriptional regulation of VEGF in LNCaP prostate cancer cells. | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | Angiogenesis | STAT3 is involved in prostate cancer angiogenesis by targeting VEGF, supported by experiments on hypoxic PC-3 cells.. | Reference |
| SMAD3 | SMAD family member 3 | Transcription Regulatory Protein | Angiogenesis | SMAD3 functions as a critical angiogenesis switch and regulates the expression of several angiogenic molecules in androgen independent prostate cancer cell lines. | Reference |
| TGFBR2 | Transforming growth factor, beta receptor II | Receptor Serine/threonine Kinase | Angiogenesis | Over-expression of TGF-beta aids tumorigenesis by not only stimulating angiogenesis and suppressing the immune system, but also by acting directly on the prostate tumor cells | Reference |
| PDGFRB | Platelet-derived growth factor receptor, beta polypeptide | Receptor Tyrosine Kinase | Angiogenesis | PDGFRB mediated signaling promotes angiogenesis in prostate cancer. | Reference |
| PDGFRB | Platelet-derived growth factor receptor, beta polypeptide | Receptor Tyrosine Kinase | Angiogenesis | siRNA mediated silencing of PDGFRB in mouse model results in significant reduction of microvessel density in prostate cancer. | Reference |
| FGFR1 | Fibroblast growth factor receptor 1 | Receptor Tyrosine Kinase | Angiogenesis | FGFR1 is involved in prostate cancer angiogenesis and angiopoietins functions as downstream effectors of FGFR1 activation, supported by a transgenic mouse model. | Reference |
| MET | Met proto-oncogene | Receptor Tyrosine Kinase | Angiogenesis | c-MET is associated with induction of angiogenesis through its effects on microvessel density of human prostate cancer. | Reference |
| PDGFRA | Platelet-derived growth factor receptor, alpha polypeptide | Receptor Tyrosine Kinase | Angiogenesis | PDGFRA is involved in prostate cancer angiogenesis as in prostate cancer xenograft mice treated with siPDGFRA shows a significant decrease in microvessel density. | Reference |
| CXCR4 | Chemokine (C-X-C motif) receptor 4 | G protein Coupled Receptor | Angiogenesis | CXCL12/CXCR4 mediated signaling is involved in prostate cancer angiogenesis | Reference |
| CXCR4 | Chemokine (C-X-C motif) receptor 4 | G protein Coupled Receptor | Angiogenesis | high levels of CXCL12 signals through CXCR4 and there by inhibits, PGK1,the 'angiogenic switch' and enhances angiogenesis | Reference |
| AR | Androgen receptor | Nuclear Receptor | Angiogenesis | AR mediates prostate cancer angiogenesis through VEGF expression by AR-SP1 complex formation. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Angiogenesis | Targeting AR signaling inhibit the wound healing process by altering macrophage infiltration as well as cytokine expressiopn profile | Reference |
| CEACAM1 | Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | Adhesion Molecule | Angiogenesis | CEACAM1 is downregulated in human prostate cancer and mediates tumour suppressive functions by inhibiting tumour angiogenesis in androgen independent prostate cancer cell line. | Reference |
| PRKCA | Protein kinase C, alpha | Serine/Threonine Kinase | Angiogenesis | Protein kinase C alpha (PKCA) is involved in prostate cancer angiogenesis through PKCalpha/c-Src/IKK/NF-kappaB signaling cascades leading to COX-2-mediated PGE2 production and MMP-2 activation in PC-3 xenograft model. | Reference |
| MAPK3 | Mitogen-activated protein kinase 3 | Serine/Threonine Kinase | Angiogenesis | MAPK3 is involved in prostate cancer angiogenesis in response of osteopontin/alphavbeta3 signaling pathway and mediates the expression of VEGF in androgen independent prostate cancer cell line. | Reference |
| MAPK3 | Mitogen-activated protein kinase 3 | Serine/Threonine Kinase | Angiogenesis | miR-21 induces prostate cancer angiogenesis through activation of ERK1/2 mediated signaling and enhancing HIF-1alpha and VEGF expression. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Angiogenesis | miR-21 induces prostate cancer angiogenesis through activation of AKT1 mediated signaling and enhancing HIF-1alpha and VEGF expression in androgen independent prostate cancer cell line. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Angiogenesis | PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis | Reference |
| SRC | V-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog | Tyrosine Kinase | Angiogenesis | SRC is involved in prostate cancer angiogenesis through Src/FAK/Rho GTPase mediated signaling in both androgen dependent & independent prostate cancer cell line.. | Reference |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | GTPase | Angiogenesis | It is involved in a complex formation downstream of NADPH oxidase and there by triggers prostate cancer angiogenesis through HIF1alpha mediated manner. | Reference |
| FRS2 | Fibroblast growth factor receptor substrate 2 | Adaptor Protein | Angiogenesis | FGF receptor substrate 2 (FRS2), an adaptor protein plays a role in promotion of human prostate cancer associated angiogenesis. | Reference |
| SRPK1 | SRSF protein kinase 1 | Dual Specificity Kinase | Angiogenesis | Serine-arginine protein kinase 1 (SRPK1), which is highly expressed in human prostate cancer plays a role in promotion of prostate tumorigenesis, possibly through stimulation of angiogenesis. | Reference |
| HIF1A | Hypoxia inducible factor 1, alpha subunit | Transcription Factor | Angiogenesis | Activation of hypoxia-inducible factor 1A(HIF1A) through interplay between miR-182 and HIF1A results in activation of HIF1A signaling pathway and there by drives human prostate cancer angiogenesis. | Reference |
| PIM3 | Pim-3 proto-oncogene, serine/threonine kinase | Serine/Threonine Kinase | Angiogenesis | PIM3, an oncogenic kinase drives human prostate cancer progression through enhancement of angiogenesis and lymphangiogenesis. | Reference |
| EPHA6 | EPH receptor A6 | Receptor Tyrosine Kinase | Angiogenesis | EPHA6, a tyrosine kinase which is overexpressed in human metastatic prostate cancer, plays a role in promotion of prostate cancer angiogenesis. | Reference |
| CACNA2D2 | Calcium channel, voltage-dependent, alpha 2/delta subunit 2 | Voltage gated channel | Angiogenesis | CACNA2D2, a voltage gated gated calcium channel component, play a significant role in human prostate tumorigenesis through stimulating prostate cancer associated angiogenesis. | Reference |
| SPAG9 | Sperm associated antigen 9 | Integral Membrane Protein | Angiogenesis | Sperm-associated antigen 9 (SPAG9), which is highly expressed in human prostate cancer, plays a role in promotion of prostate cancer associated angiogenesis. | Reference |