| Protein | Protein Name | Molecular Type | Feature | Evidence | Reference |
|---|
| SP1 | Sp1 transcription factor | Transcription Factor | Cell Motility | SP1 is involved in prostate cancer cell motility as microRNA miR-330 mediated inhibition of SP1 is associated with reduction of cell motility in prostate cancer. | Reference |
| E2F1 | E2F transcription factor 1 | Transcription Factor | Cell Invasion | E2F1 is involved in prostate cancer cell invasion and this activity is regulated by tristetraprolin (TTP). | Reference |
| E2F1 | E2F transcription factor 1 | Transcription Factor | Cell Migration | E2F1 is involved in prostate cancer cellmigration and this activity is regulated by tristetraprolin (TTP). | Reference |
| E2F1 | E2F transcription factor 1 | Transcription Factor | Cell Proliferation | E2F1 is involved in prostate cancer cell proliferation and this activity is regulated by tristetraprolin (TTP). | Reference |
| MYC | V-myc avian myelocytomatosis viral oncogene homolog | Transcription Factor | Cell Invasion | c-MYC is associated with prostate cancer cell invasion through regulating ezrin protein expression in an androgen dependent way. | Reference |
| MYC | V-myc avian myelocytomatosis viral oncogene homolog | Transcription Factor | Epithelial Mesenchymal Transition(EMT) | c-MYC is involved in prostate cancer epithelial mesenchymal transition upon phosphorylation by ERK2. | Reference |
| TP53 | Tumor protein p53 | Transcription Factor | Metastasis | Loss of TP53 results in invasion and metastasis of prostate cancer mediated by FAK-Src signaling pathway. | Reference |
| TP53 | Tumor protein p53 | Transcription Factor | Epithelial Mesenchymal Transition(EMT) | TP53 loss in prostate epithelial cell results in epithelial mesenchymal transition in prostate cancer. | Reference |
| SMAD4 | SMAD family member 4 | Transcription Factor | Metastasis | Reduced SMAD4 expression play an important role in prostate cancer metastasis. | Reference |
| SMAD4 | SMAD family member 4 | Transcription Factor | Metastasis | SMAD4 inactivation is associated with metastasis progression in prostate cancer and SMAD4 is an important regulator of prostate cancer development. | Reference |
| SMAD4 | SMAD family member 4 | Transcription Factor | Epithelial Mesenchymal Transition(EMT) | SMAD4 is involved in prostate cancer epithelial mesenchymal transition through TGFbeta/BMP-SMAD4 signaling pathway. | Reference |
| RUNX2 | Runt-related transcription factor 2 | Transcription Factor | Cell Invasion | RUNX2 play an important role in prostate cancer cell invasion through regulating matrix metaloproteinase 9 in bone metastatic prostate cancer cell. | Reference |
| RUNX2 | Runt-related transcription factor 2 | Transcription Factor | Cell Migration | RUNX2 is involved in prostate cancer cell migration as FOXO1 targets and inhibits RUNX2 and causes suppression of prostate cancer cell migration . | Reference |
| RUNX2 | Runt-related transcription factor 2 | Transcription Factor | Bone Metastasis | RUNX2 is involved in the bone metastasis of prostate cancer through alphavbeta3 integrin-Smad5-RUNX2-receptor activator of NF-kB ligand (RANKL) signaling axis. | Reference |
| WT1 | Wilms tumor 1 | Transcription Factor | Epithelial Mesenchymal Transition(EMT) | Wilm's tumour gene (WT1) play an important role in the epithelial mesenchymal transition in PC-3 prostate cancer cell. | Reference |
| WT1 | Wilms tumor 1 | Transcription Factor | Cell Migration | Wilm's tumour gene (WT1) is involved in prostate cancer cell migration as in PC-3 prostate cancer cell, silencing of WT1 results in suppression of cell migration. | Reference |
| LPXN | Leupaxin | Adaptor Protein | Cell Invasion | Plays a crucial role in prostate cancer cell invasion through transcriptional coactivation of AR in androgen independent prostate cancer cell line. | Reference |
| LPXN | Leupaxin | Adaptor Protein | Cell Invasion | Leupaxin(LPXN) is involved in prostate cancer invasion in TRAMP mice (transgenic adenocarcinoma of mouse prostate) model via downregulation of cell-cell adhesion protein p120catenin (p120CTN). | Reference |
| LPXN | Leupaxin | Adaptor Protein | Cell Motility | Leupaxin(LPXN) is involved in prostate cancer cell migration through coacivator of Androgen receptor(AR) dependent way in LNCaP cell line. | Reference |
| LPXN | Leupaxin | Adaptor Protein | Cell Adhesion | Mediates prostate cancer cell adhesion in androgen dependent and independent cell line. | Reference |
| LPXN | Leupaxin | Adaptor Protein | Cell Migration | (LPXN) regulates prostate cancer cell migration through the complex formation with Pyk2, c-Src, and PTP-PEST in androgen independent prostate cancer cell line PC-3. | Reference |
| SRF | Serum response factor (c-fos serum response element-binding transcription factor) | Transcription Factor | Cell Migration | Serum response factor(SRF) modulates prostate cancer cell migration in an androgen responsive way. | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | Metastasis | STAT3 is involved in the metastasis of prostate cancer through rearrangements of cytoplasmic actin stress fibers and microtubules | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | Cell Invasion | STAT3 is involved in TGFbeta1 mediated prostate cancer invasion. | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | Cell Motility | Inhibition of the Jak2 tyrosine kinase results in activation of Stat3 and prostate cancer cell motility in both DU145 and PC-3 cells. | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | Cell Motility | STAT3 promotes prostate cancer cell motility through Integrin beta 6 mediated signaling. | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | Cell Motility | STAT3 promotes prostate cancer cell motility through JAK2/STAT3 signaling. | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | Cell Migration | high density lipoprotein (HDL) and sphingosine-1-phosphate (S1P) activates STAT3 via ERK1/2 and promotes prostate cancer cell migration. | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | Cell Migration | STAT3 is involved in IL-6 mediated cell migration in prostate cancer DU145 cells. | Reference |
| SMAD3 | SMAD family member 3 | Transcription Regulatory Protein | Cell Invasion | Mediates prostate cancer bone metastasis through activin A-AR-SMAD3 signaling and cell invasion in a TGFBR1-SMAD3-PI3K dependent signaling. | Reference |
| SMAD3 | SMAD family member 3 | Transcription Regulatory Protein | Cell Motility | SMAD3 is associated with prostate cancer cell adhesion as a mediator of growth and differentiation factor-9(GDF-9) dependent signaling and activation of FAK and paxillin in PC-3 prostate cancer cells. | Reference |
| SMAD3 | SMAD family member 3 | Transcription Regulatory Protein | Cell Adhesion | SMAD3 is associated with prostate cancer cell adhesion as a mediator of growth and differentiation factor-9(GDF-9) dependent signaling and activation of FAK and paxillin in PC-3 prostate cancer cells. | Reference |
| SMAD3 | SMAD family member 3 | Transcription Regulatory Protein | Cell Migration | SMAD3 is associated with the prostate cancer cell invasion through TGFBR1-SMAD3-PI3-kinase signaling. | Reference |
| SMAD3 | SMAD family member 3 | Transcription Regulatory Protein | Bone Metastasis | SMAD3 play an important role in the activation of AR and Activin A-AR-SMAD3 signaling axis is involved in prostate cancer bone metastasis. | Reference |
| SMAD7 | SMAD family member 7 | Transcription Regulatory Protein | Cell Migration | SMAD7 is involved in prostate cancer cell migration in a TGF beta dependent way. | Reference |
| EEF1A1 | Eukaryotic translation elongation factor 1 alpha 1 | Transcription Regulatory Protein | Cell Proliferation | Eukaryotic elongation factors EEF1A1 is involved in prostate cancer cell proliferation in prostate cancer cell line LNCaP, DU-145, PC-3. | Reference |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | GTPase | Metastasis | RAC1 is involved in prostate cancer metastasis through EPHA2-VAV3-RAC1 signaling axis. | Reference |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | GTPase | Cell Motility | RAC1 is involved in prostate cancer cell motility driven by 14-3-3 zita dimerization. | Reference |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | GTPase | Cell Adhesion | RAC1 plays an important role in human prostate cancer cell adhesion. | Reference |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | GTPase | Cell Migration | RAC1 is involved in prostate cancer cell migration through actin polymerization and filopedia formation | Reference |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | GTPase | Cell Migration | TROP2 modulates RAC1 and enhance prostate cancer cell migration. | Reference |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | GTPase | Bone Metastasis | RAC1 is an important mediator of prostate cancer cell-bone marrow endothelial cell interactions. | Reference |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | GTPase | Bone Metastasis | RAC1 play an important role in prostate cancer bone metastasis and enhancing prostate cancer cell homing and entry into bone. | Reference |
| KRAS | Kirsten rat sarcoma viral oncogene homolog | GTPase | Cell Migration | Promotes cell migration through EGFR/RAS/MAPK pathway in prostate cancer tissues and androgen independent prostate cancer cell lines. | Reference |
| PDE4D | Phosphodiesterase 4D, cAMP-specific | Enzyme Phosphodiesterase | Cell Migration | PDE4D is involved in prostate cancer cell migration as knock down of this gene reduced the cell migration rate of prostate cancer cell in vivo. | Reference |
| SOCS3 | Suppressor of cytokine signaling 3 | Adaptor Protein | Cell Proliferation | Inhibition of SOCS3 by siRNA results in suppression of proliferation in prostate cancer cells | Reference |
| BAG3 | BCL2-associated athanogene 3 | Adaptor Protein | Cell Motility | In several prostate cancer cell line, overexpression of BAG3 enhances cell motility in prostate cancer cells | Reference |
| BAG3 | BCL2-associated athanogene 3 | Adaptor Protein | Cell Adhesion | BAG3 regulates the adhesiveness in epithelial prostate cancer | Reference |
| GNB2L1 | Guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 | Adaptor Protein | Metastasis | GNB2L1(RACK1) is involved in prostate cancer metastasis in both in vito and in viovo | Reference |
| GNB2L1 | Guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 | Adaptor Protein | Cell Invasion | GNB2L1(RACK1) is associated with prostate cancer cell Cell Invasion in both in vito and in viovo | Reference |
| GNB2L1 | Guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 | Adaptor Protein | Cell Adhesion | Involved in prostate cancer cell adhesion through beta(1) integrin-RACK1-FAK-Src signaling axis in both androgen dependent and independent prostate cancer cell line; TROP-2 is a regulator of these signaling mediated event. | Reference |
| GNB2L1 | Guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 | Adaptor Protein | Cell Migration | GNB2L1(RACK1) is associated with prostate cancer cell migration in both in vito and in viovo | Reference |
| GNB2L1 | Guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 | Adaptor Protein | Cell Proliferation | GNB2L1(RACK1) is involved in prostate cancer cell proliferation in both in vito and in viovo | Reference |
| YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | Adaptor Protein | Cell Motility | 14-3-3zeta enhances prostate cancer cell-matrix interactions, motility and transendothelial migration via activation of Rac1-GTPase | Reference |
| YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | Adaptor Protein | Cell Migration | 14-3-3zeta enhances prostate cancer cell-matrix interactions, motility and transendothelial migration in vitro via activation of Rac1-GTPase | Reference |
| YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | Adaptor Protein | Cell Proliferation | 14-3-3 zeta (YWHAZ) interacts with AR and promotes prostate cancer cell proliferation in an androgen responsive way | Reference |
| DVL2 | Dishevelled segment polarity protein 2 | Adaptor Protein | Cell Invasion | Silencing of DVL2 expression decrease cell proliferation, motility , Cell Invasion and Wnt-3a, AR, MMP-2, MMP-9 expression in LNCaP prostate cancer cell | Reference |
| DVL2 | Dishevelled segment polarity protein 2 | Adaptor Protein | Cell Motility | Critically involved in prostate cancer cell motility, regulates AR,MMP2,MMP9 expression. | Reference |
| DVL2 | Dishevelled segment polarity protein 2 | Adaptor Protein | Cell Migration | Involves in androgen independent prostate cancer cell migration and its activity is regulated by miR-221 | Reference |
| DVL2 | Dishevelled segment polarity protein 2 | Adaptor Protein | Cell Proliferation | Silencing of DVL2 expression decrease cell proliferation, motility , Cell Invasion and Wnt-3a, AR, MMP-2, MMP-9 expression in LNCaP prostate cancer cell | Reference |
| FHL2 | Four and a half LIM domains 2 | Adaptor Protein | Cell Migration | Promotes cell migration in androgen independent PC-3 prostate cancer cell line and its activity is regulated by Ets-1; an androgen co regulator | Reference |
| BCAR1 | Breast cancer anti-estrogen resistance 1 | Adaptor Protein | Cell Motility | BCAR1-CRKII complex functions as a 'molecular switch' in regulation of cell motility in metastatic prostate cancer cell line Du145 | Reference |
| BCAR1 | Breast cancer anti-estrogen resistance 1 | Adaptor Protein | Cell Migration | FAK-Src-BCAR1-Crk pathway plays critical roles in cell migration of metastatic prostate cancer cell line Du145 | Reference |
| IRS1 | Insulin receptor substrate 1 | Adaptor Protein | Cell Motility | Regulates cell motility in androgen independent prostate cancer cell line and is phosphorylated by PI3K. | Reference |
| IRS1 | Insulin receptor substrate 1 | Adaptor Protein | Cell Adhesion | IRS1 is involved in regulation of prostate cancer cell adhesion in LNCaP cells. | Reference |
| CFLAR | CASP8 and FADD-like apoptosis regulator | Adaptor Protein | Metastasis | CFLAR is involved in prostate cancer metastasis by blocking proteasome mediated degradation of betacatenine | Reference |
| WASF1 | WAS protein family, member 1 | Adaptor Protein | Cell Invasion | miR-203 is a tumor suppressor and often downregulated in Prostate cancer, targets WASF1 mRNA and involved in Prostate cancer cell Cell Invasion | Reference |
| WASF1 | WAS protein family, member 1 | Adaptor Protein | Cell Migration | Promotes cell migration in DU145 and PC3 prostate cancer cell line and its mRNA is a direct target of tumour suppressor miR-203 | Reference |
| WASF1 | WAS protein family, member 1 | Adaptor Protein | Cell Proliferation | miR-203 is a tumor suppressor and often downregulated in Prostate cancer, targets WASF1 mRNA and involved in Prostate cancer cell proliferation | Reference |
| PARD3 | Par-3 family cell polarity regulator | Adaptor Protein | Cell Invasion | Influences prostate cancer cell invasion via asymmetric cell division and maintenance of cell polarity. | Reference |
| PARD3 | Par-3 family cell polarity regulator | Adaptor Protein | Cell Migration | Mutational inactivation of PARD3 gene is involved in assymmetric cell division and results in cell migratory aspects of oncogenesis | Reference |
| FADD | Fas (TNFRSF6)-associated via death domain | Adaptor Protein | Cell Invasion | Influences prostate cancer cell invasion through modulation of human telomerase reverse transcriptase expression. | Reference |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | Adaptor Protein | Cell Invasion | CRK is involved in prostate cancer cell invasion through complex formation with BCAR1 in highly invasive prostate cancer cell line PC-3, PC-3M. | Reference |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | Adaptor Protein | Cell Migration | CRK is involved in prostate cancer cell migration through complex formation with BCAR1 in highly invasive prostate cancer cell line PC-3, PC-3M. | Reference |
| TGFBR2 | Transforming growth factor, beta receptor II | Receptor Serine/threonine Kinase | Metastasis | disruption of TGF-beta signaling in prostate cancer plays a causal role in promoting tumor metastasis | Reference |
| TGFBR2 | Transforming growth factor, beta receptor II | Receptor Serine/threonine Kinase | Metastasis | disruption of TGF-beta signaling in prostate cancer plays a causal role in promoting tumor metastasis | Reference |
| TGFBR2 | Transforming growth factor, beta receptor II | Receptor Serine/threonine Kinase | Cell Invasion | During endothelial & perineural invasion TGF beta mediated enhanced secretion of CAV1 into the tumor microenvironment causes marked inhibition of prostate cancer apoptosis | Reference |
| TGFBR2 | Transforming growth factor, beta receptor II | Receptor Serine/threonine Kinase | Cell Motility | TGFBR2 promotes cell motility | Reference |
| TGFBR2 | Transforming growth factor, beta receptor II | Receptor Serine/threonine Kinase | Epithelial Mesenchymal Transition(EMT) | Increased production of TGF beta causes epithelial mesenchymal transition | Reference |
| TGFBR2 | Transforming growth factor, beta receptor II | Receptor Serine/threonine Kinase | Epithelial Mesenchymal Transition(EMT) | Increased production of TGF beta causes epithelial mesenchymal transition | Reference |
| TGFBR2 | Transforming growth factor, beta receptor II | Receptor Serine/threonine Kinase | Cell Adhesion | Loss of TGFBR2 responsiveness is involved in prostate cancer cell adhesion in bone matrix. | Reference |
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase | Metastasis | Involved in osteoblastic metastasis in prostate cancer, bone metastasis in prostate cancer | Reference |
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase | Cell Invasion | It is involved in the regulation of endoglin mediated suppression of prostate cancer cell invasion. | Reference |
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase | Cell Adhesion | BMP9 causes in vitro inhibition of cell adhesion in prostate cancer and BMPR2 is required for its function | Reference |
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase | Cell Migration | BMP9 causes in vitro inhibition of cell migration in prostate cancer and BMPR2 is required for its function | Reference |
| IGF1R | Insulin-like growth factor 1 receptor | Receptor Tyrosine Kinase | Metastasis | IGF1R is involved in human prostate cancer metastasis through its effects on MT1-MMP. | Reference |
| IGF1R | Insulin-like growth factor 1 receptor | Receptor Tyrosine Kinase | Cell Motility | IGF1R is involved in androgen independent prostate cancer cell motility through modulation of alphavbeta3 integrin and PI3-K/Akt signaling pathway. | Reference |
| IGF1R | Insulin-like growth factor 1 receptor | Receptor Tyrosine Kinase | Cell Migration | IGF1R is involved in androgen independent prostate cancer cell migration through alphavbeta3 integrin and PI3-K/Akt signaling pathway. | Reference |
| PDGFRB | Platelet-derived growth factor receptor, beta polypeptide | Receptor Tyrosine Kinase | Metastasis | Mutational inactivation of EPHB2 have an important functional consequence in prostate cancer metastasis. | Reference |
| AXL | AXL receptor tyrosine kinase | Receptor Tyrosine Kinase | Metastasis | AXL and its receptor GAS6 play an important role in human prostate cancer metastasis, supported by experiments on PC3 and DU145 prostate cancer cells. | Reference |
| AXL | AXL receptor tyrosine kinase | Receptor Tyrosine Kinase | Cell Invasion | AXL and its receptor GAS6 are involved in prostate cancer cell invasion in PC3 and DU145 prostate cancer cells. | Reference |
| AXL | AXL receptor tyrosine kinase | Receptor Tyrosine Kinase | Epithelial Mesenchymal Transition(EMT) | AXL regulates epithelial mesenchymal (EMT) marker expression in prostate cancer, supported by experiments on PC3 and DU145 prostate cancer cells. | Reference |
| AXL | AXL receptor tyrosine kinase | Receptor Tyrosine Kinase | Cell Migration | AXL and its receptor GAS6 are involved in prostate cancer cell migration in PC3 and DU145 prostate cancer cells. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | Cell Invasion | EGFR plays an important role in prostate cancer cell invasion as microRNA targeting EGFR suppressed cell invasion in androgen insensitive cell line PC3 and DU145. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | Epithelial Mesenchymal Transition(EMT) | EGFR is involved in prostate cancer epithelial mesenchymal transition in a LIV-1 induced and ERK mediated signaling. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | Cell Migration | EGFR is involved in prostate cancer cell migration through AKT dependent way. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | Cell Migration | EGFR plays an important role in prostate cancer cell migration as microRNA targeting EGFR suppressed cell migration in androgen insensitive cell line PC3 and DU145. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | Bone Metastasis | It is involved in prostate cancer bone metastasis through cell survival and regulation of bone remodeling. | Reference |
| CSF1R | Colony stimulating factor 1 receptor | Receptor Tyrosine Kinase | Bone Metastasis | CSF1R is involved in bone metastasis of advanced prostate cancer. | Reference |
| NTRK1 | Neurotrophic tyrosine kinase, receptor, type 1 | Receptor Tyrosine Kinase | Cell Invasion | NTRK1 is involved in NGF and BDNF induced protate cancer cell invasion in PC-3 and DU145 prostate cancer cell lines. | Reference |
| NTRK1 | Neurotrophic tyrosine kinase, receptor, type 1 | Receptor Tyrosine Kinase | Cell Migration | NTRK1 is associated with NGF and BDNF induced cell migration in different prostate cancer cell lines. | Reference |
| FGFR1 | Fibroblast growth factor receptor 1 | Receptor Tyrosine Kinase | Metastasis | FGFR1 is involved in prostate cancer metastasis, supported by transgenic mouse model of prostate cancer. | Reference |
| FGFR1 | Fibroblast growth factor receptor 1 | Receptor Tyrosine Kinase | Epithelial Mesenchymal Transition(EMT) | FGFR1 activation results in epithelial mesenchymal transition in the epithelial compartment during prostate cancer progression. | Reference |
| FGFR1 | Fibroblast growth factor receptor 1 | Receptor Tyrosine Kinase | Cell Migration | FGF2 & its receptor FGFR1 is involved in prostate cancer cell migration. | Reference |
| MET | Met proto-oncogene | Receptor Tyrosine Kinase | Metastasis | HGF and its receptor c-MET is involved in metastasis and invasion in DU145 prostate cancer cell line. | Reference |
| MET | Met proto-oncogene | Receptor Tyrosine Kinase | Cell Invasion | c-MET is associated with sttromal invasion of prostate cancer. | Reference |
| MET | Met proto-oncogene | Receptor Tyrosine Kinase | Cell Migration | c-MET is involved in prostate cancer cell migration in DU-145 prostate cancer cells. | Reference |
| MET | Met proto-oncogene | Receptor Tyrosine Kinase | Bone Metastasis | c-MET is involved in bone metastasis in human prostate cancer. | Reference |
| ERBB2 | V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | Receptor Tyrosine Kinase | Cell Invasion | ERBB2 is involved in prostate cancer cell invasion through ERBB2-P3K-Matripase signaling pathway. | Reference |
| ERBB2 | V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | Receptor Tyrosine Kinase | Cell Adhesion | ERBB2 is involved with prostate cancer cell adhesion through ERBB2-PYK2-ERK/MAPK pathway in androgen responsive prostate cancer cell line. | Reference |
| ERBB2 | V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | Receptor Tyrosine Kinase | Bone Metastasis | It is involved in prostate cancer bone metastasis and is trans-activated by CXCL12/CXCR4 axis. | Reference |
| EPHA2 | EPH receptor A2 | Receptor Tyrosine Kinase | Metastasis | EPHA2 is involved in prostate cancer metastasis through EphrinA1-EPHA2-VAV3-RAC1 signaling axis. | Reference |
| EPHA2 | EPH receptor A2 | Receptor Tyrosine Kinase | Cell Motility | EPHA2 is involved in prostate cancer cell motility as overexpression of EPHA2 promotes prostate cancer cell motility in PC-3 cells in ligand independent manner. | Reference |
| EPHA2 | EPH receptor A2 | Receptor Tyrosine Kinase | Cell Motility | EPHA2 is involved in prostate cancer cell motility by adopting an amoboid movement based on Rho-mediated cell rounding. | Reference |
| EPHA2 | EPH receptor A2 | Receptor Tyrosine Kinase | Cell Adhesion | EPHA2 is involved in regulation of cell adhesion and cytoskeletal rearrangement in prostate cancer. | Reference |
| EPHA2 | EPH receptor A2 | Receptor Tyrosine Kinase | Cell Migration | Arachidonic acid mediates prostate cancer epithelial cell migration in an EPHA2 dependent fashion. | Reference |
| EPHA2 | EPH receptor A2 | Receptor Tyrosine Kinase | Bone Metastasis | EPHA2 is associated with bone metastasis in prostate cancer. | Reference |
| PDGFRA | Platelet-derived growth factor receptor, alpha polypeptide | Receptor Tyrosine Kinase | Bone Metastasis | PDGFRA is involved in prostate cancer bone metastasis as the bone marrow activates PDGFRalpha in a ligand-independent fashion. | Reference |
| PRLR | Prolactin receptor | Receptor Tyrosine Kinase | Metastasis | 50% of 183 hormone-insensitive prostate cancer specimens, and 63% of prostate cancer metastases, stained for PRL | Reference |
| PRLR | Prolactin receptor | Receptor Tyrosine Kinase | Cell Proliferation | Inhibition of prolactin receptor by endocannabinoids results in suppression of prostate cancer cell proliferation | Reference |
| IFNAR1 | Interferon (alpha, beta and omega) receptor 1 | Cytokine Receptor | Metastasis | IFNAR1 is involved in acquition of prostate cancer metastatic behaviour | Reference |
| IFNAR1 | Interferon (alpha, beta and omega) receptor 1 | Cytokine Receptor | Cell Invasion | IFNAR1 is asociated with prostate cancer tumour Cell Invasion | Reference |
| IFNAR1 | Interferon (alpha, beta and omega) receptor 1 | Cytokine Receptor | Cell Invasion | IFNAR1 is asociated with prostate cancer tumour invasion | Reference |
| IFNAR1 | Interferon (alpha, beta and omega) receptor 1 | Cytokine Receptor | Cell Adhesion | IFNAR1 is involved in prostate cancer cell adhesion by modulation of cell adhesion molecule, ICAM1, Pcadherin and alpha integrin | Reference |
| CXCR4 | Chemokine (C-X-C motif) receptor 4 | G protein Coupled Receptor | Metastasis | CXCL12/CXCR4 mediated signaling is involved in regulation of metastasis in prostate cancer | Reference |
| CXCR4 | Chemokine (C-X-C motif) receptor 4 | G protein Coupled Receptor | Metastasis | Through up regulation of VEGF and MMP9, CXC4 mediates prostate cancer metastasis | Reference |
| CXCR4 | Chemokine (C-X-C motif) receptor 4 | G protein Coupled Receptor | Cell Invasion | It plays a role in SLUG mediated cell invasion in androgen independent prostate cancer cell line. | Reference |
| CXCR4 | Chemokine (C-X-C motif) receptor 4 | G protein Coupled Receptor | Cell Adhesion | CXCR4 enhances prostate cancer cell migration through alpha5 and beta3 integrins | Reference |
| CXCR4 | Chemokine (C-X-C motif) receptor 4 | G protein Coupled Receptor | Cell Migration | SLUG and CXCL12 enhances prostate cancer cell migration through CXCR4. | Reference |
| CXCR4 | Chemokine (C-X-C motif) receptor 4 | G protein Coupled Receptor | Cell Proliferation | CXCR4 mediated signaling is involved in prostate cancer epithelial cell proliferation | Reference |
| PHB | Prohibitin | Adaptor Protein | Cell Proliferation | Prohibitin(PHB), a cell cycle regulatory protein is involved in prostate cancer cell proliferation in an androgen receptor dependent manner in LNCaP cells. | Reference |
| NGFR | Nerve growth factor receptor | Cell Surface Receptor | Metastasis | NGFR(p75NTR) functions as a metastatic suppressor in prostate cancer by down regulation of uPA, MMP-2, MMP-9, and TIMP-1. | Reference |
| NGFR | Nerve growth factor receptor | Cell Surface Receptor | Cell Invasion | NGFR(p75NTR) re-expression in stromal smooth muscle cells is related to the prostate cancer tumour cell invasion. | Reference |
| NGFR | Nerve growth factor receptor | Cell Surface Receptor | Cell Migration | NGFR(p75NTR) is involved in prostate cancer cell migration via NGFR(p75NTR)-P38mapk-nag1 pathway. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Metastasis | Endothelial cells augments prostate cancer metastasis via IL-6?androgen receptor?TGF-beta?MMP-9 signaling pathway | Reference |
| AR | Androgen receptor | Nuclear Receptor | Cell Invasion | Mediates prostate cancer cell invasion by endothelial cells through IL-6-AR-TGFbeta-MMP9 signaling. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Cell Motility | Androgen receptor is involved in prostate cancer cell motility through SRC-FAK-PI3K-CDC42-RAC1 cascade. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Cell Motility | Androgen receptor stimulates PAK6 by direct interaction and PAK6 activation enhance prostate cancer cell motility & Cell Invasion | Reference |
| AR | Androgen receptor | Nuclear Receptor | Cell Motility | Androgen receptor stimulates PAK6 by direct interaction and PAK6 activation enhance prostate cancer cell motility & invasion | Reference |
| AR | Androgen receptor | Nuclear Receptor | Epithelial Mesenchymal Transition(EMT) | Androgen receptor mediated signaling is responsible for epithelial mesenchymal transition in prostate epithelial cells | Reference |
| AR | Androgen receptor | Nuclear Receptor | Epithelial Mesenchymal Transition(EMT) | Androgen receptor mediated signaling is responsible for epithelial mesenchymal transition in prostate epithelial cells | Reference |
| AR | Androgen receptor | Nuclear Receptor | Cell Migration | Androgen receptor play an important role in prostate cancer cell migration through activin A-Smad-AR axis. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Cell Migration | Androgen receptor target gene TM4SF1 is overexpressed in human prostate cancer and is involved in prostate cancer cell migration | Reference |
| AR | Androgen receptor | Nuclear Receptor | Cell Migration | AR/FlnA/integrin beta 1 complex is the key by which androgen activates signaling leading to prostate cancer cell migration | Reference |
| AR | Androgen receptor | Nuclear Receptor | Cell Proliferation | Cell proliferation is linked to ribosome biogenesis which is stimulated by AR and Estrogen receptor signaling in prostate cancer | Reference |
| VAV3 | Vav 3 guanine nucleotide exchange factor | Guanine Nucleotide Exchange Factor | Cell Invasion | VAV3 is associated with prostate cancer cell invasion through ephrinA1-EphA2-Vav3-Rac1 signaling axis. | Reference |
| VAV3 | Vav 3 guanine nucleotide exchange factor | Guanine Nucleotide Exchange Factor | Cell Migration | VAV3 is associated with prostate cancer cell migration through ephrinA1-EphA2-Vav3-Rac1 signaling axis. | Reference |
| GOLM1 | Golgi membrane protein 1 | Transport/Cargo Protein | Cell Invasion | Golgi membrane protein 1 (GOLM1) is involved in prostate cancer cell invasion as inhibition of GOLM1 results in significant suppression of prostate cancer cell invasion. | Reference |
| GOLM1 | Golgi membrane protein 1 | Transport/Cargo Protein | Cell Proliferation | Golgi membrane protein 1 (GOLM1) is involved in prostate cancer cell proliferation as inhibition of GOLM1 results in significant suppression of prostate cancer cell proliferation. | Reference |
| CDKN1B | Cyclin-dependent kinase inhibitor 1B (p27, Kip1) | Cell Cycle Control Protein | Cell Invasion | CDKN1B(p27) is associated with prostate cancer cell invasion as downregulation of p27(Kip1) by XMRV infection results in enhancement of cell invasion. | Reference |
| PIAS1 | Protein inhibitor of activated STAT, 1 | Cell Cycle Control Protein | Cell Proliferation | Protein inhibitor of activated signal transducers and activators of transcription (PIAS)1 play an important role in regulation of cell proliferation in prostate cancer through inhibition of p21.. | Reference |
| FRS2 | Fibroblast growth factor receptor substrate 2 | Adaptor Protein | Cell Invasion | FRS2 is involved in prostate cancer cell invasion in a FGF-FGFR dependent signaling in DU145 cells. | Reference |
| FRS2 | Fibroblast growth factor receptor substrate 2 | Adaptor Protein | Cell Migration | FRS2 is involved in prostate cancer cell migration in a FGF-FGFR dependent signaling in DU145 cells. | Reference |
| ITGB4 | Integrin, beta 4 | Adhesion Molecule | Cell Invasion | (ITGB4)beta4 integrin enhance human prostate cancer cell invasion by amplifying receptor tyrosine kinase mediated signaling. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Cell Invasion | Beta catenine(CTNNB1) is associated invasion of prostate cancer cells. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Epithelial Mesenchymal Transition(EMT) | Beta catenine is associated with epithelial mesenchymal transition in prostate cancer development mediated by SOX2. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Epithelial Mesenchymal Transition(EMT) | Beta catenine is involved in the epithelial mesenchymal transition of prostate cancer stem cell through HIF-1alpha/beta-catenin-dependent signaling pathway. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Cell Migration | Beta catenine is involved in the migration of prostate cancer stem cell through HIF-1alpha/beta-catenin-dependent signaling pathway. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Bone Metastasis | Beta catenine over expression is related to prostate cancer bone metastasis. | Reference |
| APC | Adenomatous polyposis coli | Adhesion Molecule | Cell Migration | APC and SMAD7 play an important role in prostate cancer cell migration by establishing a link between TGFBR1 and microtubule system. | Reference |
| MAPK14 | Mitogen-activated protein kinase 14 | Serine/Threonine Kinase | Cell Invasion | MAPK14(p38 alpha) along with ERK2 play an important role in the regulation of prostate cancer cancer cell invasion in response of LPA stimulation. | Reference |
| MAPK14 | Mitogen-activated protein kinase 14 | Serine/Threonine Kinase | Cell Migration | MAPK14(p38 alpha) is involved in prostate cancer cell migration along with ERK2 in a LPA induced manner in the PC-3 prostate cancer cell line. | Reference |
| PRKCA | Protein kinase C, alpha | Serine/Threonine Kinase | Cell Invasion | Protein kinase C alpha (PKCA) is associated with prostate cancer cell invasion in an androgen responsive way. | Reference |
| MAPK3 | Mitogen-activated protein kinase 3 | Serine/Threonine Kinase | Cell Invasion | MAPK3(ERK1) activation is an important step in CXCL13-mediated prostate cancer cell invasion. | Reference |
| MAPK3 | Mitogen-activated protein kinase 3 | Serine/Threonine Kinase | Cell Invasion | MAPK3(ERK1) phosphorylation in response of human chorionic gonadotropin beta (hCGbeta) is associated with prostate cancer cell invasion. | Reference |
| MAPK3 | Mitogen-activated protein kinase 3 | Serine/Threonine Kinase | Cell Motility | MAPK3(ERK1) phosphorylation in response of human chorionic gonadotropin beta (hCGbeta) is associated with prostate cancer cell motility. | Reference |
| MAPK3 | Mitogen-activated protein kinase 3 | Serine/Threonine Kinase | Cell Migration | MAPK3(ERK1) phosphorylation in response of human chorionic gonadotropin beta (hCGbeta) is associated with prostate cancer cell migration. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Cell Invasion | AKT1 is associated with prostate cancer cell invasion through the aberrant activation of PI3K-Akt pathway. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Cell Invasion | AKT1 is involved in prostate cancer cell invasion in an integrin alpha(v)beta(3) dependent manner. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Cell Motility | AKT1 is involved in prostate cancer cell motility in an integrin alpha(v)beta(3) dependent manner. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Cell Migration | AKT1 is involved in prostate cancer trans endothelial migration in an integrin alpha(v)beta(3) dependent manner. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Cell Migration | PI3K/AKT1 pathway play an important role in prostate cancer cell migration through HGF/SF responsive way | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Bone Metastasis | AKT1 is involved in prostate cancer bone metastasis in an integrin alpha(v)beta(3) dependent manner. | Reference |
| FRS3 | Fibroblast growth factor receptor substrate 3 | Adaptor Protein | Cell Invasion | FRS3 is involved in prostate cancer cell invasion in a FGF-FGFR dependent signaling in DU145 cells. | Reference |
| FRS3 | Fibroblast growth factor receptor substrate 3 | Adaptor Protein | Cell Migration | FRS3 is involved in prostate cancer cell migration in a FGF-FGFR dependent signaling in DU145 cells. | Reference |
| CDK5 | Cyclin-dependent kinase 5 | Serine/Threonine Kinase | Metastasis | CDK5 regulates the metastatic potential of prostate cancer by influencing many steps associated with metastasis. | Reference |
| CDK5 | Cyclin-dependent kinase 5 | Serine/Threonine Kinase | Cell Motility | CDK5 is involved in the regulation of prostate cancer cell motility. | Reference |
| GSK3B | Glycogen synthase kinase 3 beta | Serine/Threonine Kinase | Cell Proliferation | GSK3B is involved in both androgen dependent and androgen independent prostate cancer cell proliferation through GSK-3/AR signaling axis. | Reference |
| PIM2 | Pim-2 oncogene | Serine/Threonine Kinase | Cell Invasion | PIM2 is involved in the perineural invasion during prostate cancer progression. | Reference |
| TYK2 | Tyrosine kinase 2 | Tyrosine Kinase | Cell Invasion | TYK2 is involved in the prostate cancer cell invasion. | Reference |
| JAK2 | Janus kinase 2 | Tyrosine Kinase | Cell Motility | JAK2 is involved in prostate cancer cell motility through JAK2-STAT3 mediated signaling as JAK2 inhibition results in reduced activation of STAT3 and suppression of prostate cancer cell motility. | Reference |
| FYN | FYN oncogene related to SRC, FGR, YES | Tyrosine Kinase | Cell Motility | FYN is involved in the prostate cancer cell motility through both integrin and receptor tyrosine kinase mediated manner. | Reference |
| SRC | V-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog | Tyrosine Kinase | Metastasis | SRC kinase is involved in prostate cancer metastasis by regulating the expression of E-cadherin demonstrated by tumour xenograft model. | Reference |
| SRC | V-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog | Tyrosine Kinase | Cell Motility | SRC is involved in the prostate cancer cell motility along with FAK. | Reference |
| SRC | V-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog | Tyrosine Kinase | Cell Adhesion | Mediates prostate cancer cell adhesion through beta(1) integrin-RACK1-FAK-SRC signaling pathway in androgen dependent and independent prostate cancer cell line. | Reference |
| SRC | V-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog | Tyrosine Kinase | Cell Migration | Src is involved in prostate cancer cell migration in a bradykinin dependent ways. | Reference |
| SRC | V-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog | Tyrosine Kinase | Cell Migration | SRC is involved in prostate cancer cell migration in CCL2 and CCCR2 responsive ways mediated by PKCdelta, c-Src, and AP-1. | Reference |
| SRC | V-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog | Tyrosine Kinase | Bone Metastasis | SRC kinase play an important role in bone metastasis of prostate cancer. | Reference |
| SRC | V-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog | Tyrosine Kinase | Lymph node Metastasis | SRC is involved in lymph node metastasis during prostate cancer progression. | Reference |
| PXN | Paxillin | Cytoskeletal Associated Protein | Cell Invasion | Paxillin(PXN) is involved in the prostate cancer cell invasion through FAK/src/paxillin/Rac/JNK signaling resulting in the activation of MMP-2 and MMP-9 in prostate cancer LNCaP cell line. | Reference |
| PXN | Paxillin | Cytoskeletal Associated Protein | Cell Motility | Paxillin is involved in the prostate cancer cell motility in a GDF9 responsive way and SMAD dependent manner in PC-3 prostate cancer cell line. | Reference |
| PXN | Paxillin | Cytoskeletal Associated Protein | Cell Adhesion | Paxillin is involved in the prostate cancer cell adhesion in a GDF9 responsive way and SMAD dependent manner in PC-3 prostate cancer cell line. | Reference |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | Membrane transport protein | Cell Proliferation | ATP2A2(SERCA2) is involved in prostate call proliferation in a prolactin mediated manner in SV40 immortalized epithelial prostate (PNT1A) cells. | Reference |
| WASF3 | WAS protein family, member 3 | Cytoskeletal Associated Protein | Metastasis | WASF3 plays an important role in the promotion of metastasis in prostate cancer PC3 and DU145 cells. | Reference |
| WASF3 | WAS protein family, member 3 | Cytoskeletal Associated Protein | Cell Invasion | WASF3(WAVE3) is involved in the regulation of invasiveness in the prostate cancer cell line PC-3 and DU-145. | Reference |
| WASF3 | WAS protein family, member 3 | Cytoskeletal Associated Protein | Cell Motility | WASF3 play an important role in prostate cancer cell motility in a IL6 responsive way mediated by JAK2/STAT3 signaling. | Reference |
| BCAR1 | Breast cancer anti-estrogen resistance 1 | Adaptor Protein | Cell Invasion | Regulates prostate cancer cell invasion through CRK-BCAR1 complex formation | Reference |
| RUNX2 | Runt-related transcription factor 2 | Transcription Factor | Cell Invasion | It's a osteogenic transcription factor and regulates cell invasion in androgen independent prostate cancer cell line. | Reference |
| SMAD3 | SMAD family member 3 | Transcription Regulatory Protein | Cell Invasion | It is involved in prostate cancer cell invasion in androgen independent prostate cancer cell line. | Reference |
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase | Cell Invasion | Mediates osteoblastic metastasis in prostate cancer ; regulates prostate cancer cell invasion. | Reference |
| BCAR1 | Breast cancer anti-estrogen resistance 1 | Adaptor Protein | Cell Migration | Functions as a cell migration switch in in highly invasive prostate cancer PC-3M and PC-3 cell lines. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Cell Motility | Influences prostate cancer cell motility through E-cadherin and PKD1. | Reference |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | Adaptor Protein | Cell Motility | Function as a switch in regulation of cell motility in prostate cancer. | Reference |
| PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | Adaptor Protein | Cell Motility | Promotes cell motility in a bradykinine responsive manner and through PI3K/AKT1 pathway. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | Cell Motility | Promotes prostate cancer cell motility through AKT1. | Reference |
| BCAR1 | Breast cancer anti-estrogen resistance 1 | Adaptor Protein | Cell Adhesion | Mediates formation of peripheral adhesion complex through PTK6-p130CAS-ERK5 signaling cascade. | Reference |
| PXN | Paxillin | Cytoskeletal Associated Protein | Cell Adhesion | Involved in the regulation of prostate cancer cell adhesion in a alpha2 integrin mediated manner through FAK/src/paxillin/Rac/JNK signaling in androgen independent cell line. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | Epithelial Mesenchymal Transition(EMT) | SPINK1, which is overexpressed in prostate cancer promotes EMT through EGFR signaling. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Epithelial Mesenchymal Transition(EMT) | It promotes prostate cancer metastasis by regulating EMT. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Epithelial Mesenchymal Transition(EMT) | Androgen deprivation therapy mediates prostate cancer EMT through a feed back loop involving AR and Zeb1 transcription factor. | Reference |
| TP53 | Tumor protein p53 | Transcription Factor | Epithelial Mesenchymal Transition(EMT) | Loss of TP53 enhances EMT and stemness of prostate cancer cells through partially through repressing miR-145. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Epithelial Mesenchymal Transition(EMT) | EPLIN downregulation in metastatic prostate cancer results in the activation of beta catenine mediated pro-EMT gene expression. | Reference |
| PDGFRA | Platelet-derived growth factor receptor, alpha polypeptide | Receptor Tyrosine Kinase | Bone Metastasis | It is involved in stronger activation of the Akt/PKB survival pathway in bone-metastatic prostate cancer cells. | Reference |
| EPHA2 | EPH receptor A2 | Receptor Tyrosine Kinase | Bone Metastasis | It is involved in prostate cancer bone metastasis through EphA2-Vav3-Rac1 signaling axis. | Reference |
| SRC | V-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog | Tyrosine Kinase | Bone Metastasis | It is involved in prostate cancer bone metastasis by playing a role in osteoclast mediated bone resorption, tumour growth and metastasis. | Reference |
| JAK2 | Janus kinase 2 | Tyrosine Kinase | Epithelial Mesenchymal Transition(EMT) | JAK2-STAT5a/b mediated signaling plays a role in prostate cancer epithelial mesenchymal transition. | Reference |
| FOXO1 | Forkhead box O1 | Transcription Factor | Cell Migration | Downregulation of FOXO1 expression in human prostate cancer through MiR-182, plays a role in enhancement of prostate cancer cell migration. | Reference |
| FOXO1 | Forkhead box O1 | Transcription Factor | Cell Proliferation | Downregulation of FOXO1 expression in human prostate cancer through MiR-182, plays a role in enhancement of prostate cancer cell proliferation. | Reference |
| FOXO1 | Forkhead box O1 | Transcription Factor | Cell Invasion | Downregulation of FOXO1 expression in human prostate cancer through MiR-182, plays a role in enhancement of prostate cancer cell invasion. | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | Bone Metastasis | STAT3, a transcription factor which is overexpressed in bone metastatic prostate cancer cell and plays a role in prostate cancer bone metastasis by stimulating Cathepsin L synthesis through JAK2/STAT3 signaling axis. | Reference |
| FAK | Protein tyrosine kinase 2 | Tyrosine Kinase | Cell Motility | Functions in MIC-1 mediated actin reorganization through FAK-RhoA signaling pathway in both androgen dependent and independent prostate cancer cell line | Reference |
| DAB2IP | DAB2 interacting protein | Ras GTPase-activating protein | Epithelial Mesenchymal Transition(EMT) | Loss of DAB2IP is associated with prostate cancer epithelial mesenchymal transition , supported by experiments on human prostate xenograft-mouse model. | Reference |
| ESR2 | Estrogen receptor 2 (ER beta) | Transcription Factor | Bone Metastasis | Estrogen receptor beta 2 is involved in advanced prostate cancer and play very important role in prostate cancer bone metastasis | Reference |
| PML | Promyelocytic leukemia | Transcription Regulatory Protein | Epithelial Mesenchymal Transition(EMT) | Cytoplasmic promyelocytic leukaemia (cPML) plays a very critical role in the induction of prostate cancer associated epithelial mesenchymal transition (EMT) through activation of TGF beta mediated signaling. | Reference |
| TWIST1 | Twist family bHLH transcription factor 1 | Transcription Factor | Epithelial Mesenchymal Transition(EMT) | TWIST1 transcription factor plays a vital role in human prostate cancer associated epithelial mesenchymal transition through interaction with androgen receptor(AR) and there by promotes castration resistance. | Reference |
| POSTN | Periostin, osteoblast specific factor | Adhesion Molecule | Epithelial Mesenchymal Transition(EMT) | Periostin(POSTN), which is upregulated in human prostate cancer plays a role in prostate cancer related epithelial mesenchymal transition (EMT) in a TGF beta dependent manner. | Reference |
| CFD | Complement factor D (adipsin) | Enzyme | Epithelial Mesenchymal Transition(EMT) | Adiponectin (CFD), a hormone secreted by adipose tissue and frequently inactivated in human prostate cancer, plays a tumour suppressive role in the context of prostate cancer associated epithelial mesenchymal transition. | Reference |
| PAK1 | p21 protein (Cdc42/Rac)-activated kinase 1 | Serine/Threonine Kinase | Epithelial Mesenchymal Transition(EMT) | P21-activated kinase1 (PAK1) plays a role in prostate cancer epithelial mesenchymal transition through a TGF-Beta deependent signaling pathway. | Reference |
| PARP1 | Poly(ADP-ribose) polymerase 1 | Enzyme | Epithelial Mesenchymal Transition(EMT) | Poly (ADP-ribose) polymerase (PARP) is involved in the promotion of prostate cancer associated epithelial mesenchymal transition (EMT) ina TGF beta responsive manner. | Reference |
| FGF19 | Fibroblast growth factor 19 | Growth Factor | Epithelial Mesenchymal Transition(EMT) | FGF19, highly expressed in human prostate cancer, plays a role in prostate cancer associated epithelial mesenchymal transition (EMT). | Reference |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 | Extracellular Matrix Protein | Cell Invasion | EFEMP1 inactivation through promoter methylation, plays a role in human prostate cancer associated cell invasion. | Reference |
| ACSL4 | Acyl-CoA synthetase long-chain family member 4 | Enzyme | Cell Invasion | Long-chain fatty acyl-CoA synthetase 4 (ACSL4), which is upregulated in human prostate cancer, is involved in prostate cancer cell invasion. | Reference |
| PIWIL2 | Piwi-like RNA-mediated gene silencing 2 | Transcription Regulatory Protein | Epithelial Mesenchymal Transition(EMT) | Piwi-like RNA-mediated gene silencing 2 (Piwil2), an oncogene which is upregulated in human prostate cancer, plays a significant role in modulation of prostate cancer associated epithelial mesenchymal transition (EMT) through regulation of MMP9 expression. | Reference |
| PIWIL2 | Piwi-like RNA-mediated gene silencing 2 | Transcription Regulatory Protein | Cell Invasion | Piwi-like RNA-mediated gene silencing 2 (Piwil2), an oncogene which is upregulated in human prostate cancer, plays a significant role in prostate cancer cell invasion through regulation of MMP9 expression. | Reference |
| ZAP70 | Zeta chain of T cell receptor associated protein kinase 70kDa | Tyrosine Kinase | Cell Migration | Zeta-associated protein 70 (ZAP70) plays a role in human prostate cancer cell migration as its regulator MiR-631 is downregulated during prostate cancer progression. | Reference |
| ZAP70 | Zeta chain of T cell receptor associated protein kinase 70kDa | Tyrosine Kinase | Cell Invasion | Zeta-associated protein 70 (ZAP70) plays a role in human prostate cancer cell invasion as its regulator MiR-631 is downregulated during prostate cancer progression. | Reference |
| CDH11 | Cadherin 11, type 2, OB-cadherin (osteoblast) | Cell Junction Protein | Cell Migration | Cadherin-11 (CDH11), a cell adhesion molecule which is internalized in human prostate cancer cell through clathrin dependent ways, plays a role in the regulation of prostate cancer cell migration. | Reference |
| FRA-1 | FOS-like antigen 1 | Transcription Factor | Cell Migration | FRA-1 plays a role in human prostate cancer associated cell migration as its regulator MiR-195 (a tumour suppressor) is frequently down regulated during prostate cancer development. | Reference |
| FRA-1 | FOS-like antigen 1 | Transcription Factor | Cell Invasion | FRA-1 plays a role in human prostate cancer associated cell invasion as its regulator MiR-195 (a tumour suppressor) is frequently down regulated during prostate cancer development. | Reference |
| TCTN1 | Tectonic family member 1 | Unclassified | Cell Migration | TCTN1, which is involved in human embryonic development, plays a role in human prostate cancer cell migration through regulation of cytoskeletal remodelling. | Reference |
| SNAIL | Snail family zinc finger 1 | Transcription Regulatory Protein | Cell Migration | SNAIL, a zinc-finger transcription factor drives human prostate cancer cell migration through activation of PI3K/AKT/RAC1 signaling axis. | Reference |
| PTTG1 | Pituitary tumor-transforming 1 | Transcription Regulatory Protein | Cell Invasion | Pituitary tumor-transforming gene 1 (PTTG1) is involved in the regulation prostate cancer cell invasion through matrix metalloproteinase 13 (MMP13). | Reference |
| EPLIN | LIM domain and actin binding 1 | Cytoskeletal Protein | Epithelial Mesenchymal Transition(EMT) | EPLIN, an actin associated molecule, plays a pivotal role in regulation of prostate cancer associated epithelial mesenchymal transition (EMT). | Reference |
| UBE2T | Ubiquitin conjugating enzyme E2T | Ubiquitin proteasome system protein | Cell Motility | Ubiquitin-conjugating enzyme E2T (UBE2T), which is highly expressed in human prostate cancer, plays a role in human prostate cancer associated cell motility. | Reference |
| UBE2T | Ubiquitin conjugating enzyme E2T | Ubiquitin proteasome system protein | Cell Invasion | Ubiquitin-conjugating enzyme E2T (UBE2T), which is highly expressed in human prostate cancer, plays a role in human prostate cancer associated cell invasion. | Reference |
| EIF3D | Eukaryotic translation initiation factor 3 subunit D | Translation Regulatory Protein | Cell Migration | EIF3 is highly expressed in human prostate cancer, plays a role in prostate cancer cell migration. | Reference |
| TLN1 | Talin 1 | Cytoskeletal associated protein | Cell Motility | Talin 1, overexpressed in human prostate cancer and is significantly associated with prostate cancer cell motiility. | Reference |
| TLN1 | Talin 1 | Cytoskeletal associated protein | Cell Adhesion | Talin 1, overexpressed in human prostate cancer and plays a role in prostate cancer associated cell adhesion. | Reference |
| LCN2 | Lipocalin 2 | Transport/Cargo Protein | Cell Motility | Lipocalin 2 (LCN2), a member of the lipocalin family, is highly expressed in human prostate cancer and plays a role in enhancement of prostate cancer associated cell motility. | Reference |
| LCN2 | Lipocalin 2 | Transport/Cargo Protein | Cell Invasion | Lipocalin 2 (LCN2), a member of the lipocalin family, is highly expressed in human prostate cancer and plays a role in enhancement of prostate cancer associated cell invasion. | Reference |
| LCN2 | Lipocalin 2 | Transport/Cargo Protein | Epithelial Mesenchymal Transition(EMT) | Lipocalin 2 (LCN2), a member of the lipocalin family, is highly expressed in human prostate cancer and is involved in the induction of prostate cancer associated epithelial mesenchymal transition (EMT) through regulation of SLUG expression via ERK pathway activation. | Reference |
| YAP1 | Yes associated protein 1 | Transcription Regulatory Protein | Cell Motility | Yes-associated protein (YAP), a crucial effector of the hippo tumor suppressor pathway, plays a role in the regulation of human prostate cancer associated cell motility. | Reference |
| YAP1 | Yes associated protein 1 | Transcription Regulatory Protein | Cell Invasion | Yes-associated protein (YAP), a crucial effector of the hippo tumor suppressor pathway, plays a role in the regulation of human prostate cancer associated cell invasion and there by promotes metastasis.. | Reference |
| AQP3 | Aquaporin 3 | Water Channel | Cell Motility | Aquaporin 3 (AQP3) critically mediated human prostate cancer associated cell motility through upregulation of MMP3 expression via ERK1/2 activation. | Reference |
| AQP3 | Aquaporin 3 | Water Channel | Cell Invasion | Aquaporin 3 (AQP3) critically mediated human prostate cancer associated cell invasion through upregulation of MMP3 expression via ERK1/2 activation. | Reference |
| P2X7 | Purinergic receptor P2X, ligand gated ion channel, 7 | Extracellular ligand gated channel | Cell Invasion | ATP-gated P2X7 plays a significant role in promotion of human prostate cancer cell invasion through activation of PI3K/AKT and ERK1/2 signaling pathways. | Reference |
| IL17 | Interleukin 17A | Cytokine | Cell Adhesion | Interleukin-17 (IL-17) is involved in mediating adhesion of prostate cancer cells to the vascular endothelial cells through CD44-VCAM-1 interaction. | Reference |
| INS | Insulin | Growth Factor | Cell Adhesion | Insulin (INS)/IGF1 plays a role in in mediating adhesion of prostate cancer cells to the vascular endothelial cells through CD44-VCAM-1 interaction. | Reference |
| RAP1A | RAP1A, member of RAS oncogene family | GTPase | Cell Adhesion | RAP1A, which is upregulated in human prostate cancer, plays a role in prostate cancer cell adhesion as its critical negative regulator MiR-203 is significantly downregulated in human prostate cancer. | Reference |
| RAP1A | RAP1A, member of RAS oncogene family | GTPase | Cell Invasion | RAP1A, which is upregulated in human prostate cancer, plays a role in prostate cancer cell invasion as its critical negative regulator MiR-203 is significantly downregulated in human prostate cancer. | Reference |
| CXCL12 | Chemokine (C-X-C motif) ligand 12 | Chemokine | Cell Adhesion | CXCL12 plays a significant role in modulation of human prostate cancer associated cell adhesion through regulating integrins. | Reference |
| ESL-1 | E-selectin ligand 1 | Integral Membrane Protein | Cell Adhesion | E-selectin ligand 1(ESL-1) plays a significant role in human prostate cancer cell adhesion through activation of RAS and MAPK mediated signaling and there by promotes prostate cancer metastasis. | Reference |
| SPAG9 | Sperm associated antigen 9 | Integral Membrane Protein | Cell Motility | Sperm-associated antigen 9 (SPAG9), which is highly expressed in human prostate cancer, plays a role in promotion of prostate cancer associated cell motility and there by facilitates metastatic progression. | Reference |
| SPAG9 | Sperm associated antigen 9 | Integral Membrane Protein | Cell Invasion | Sperm-associated antigen 9 (SPAG9), which is highly expressed in human prostate cancer, plays a role in promotion of prostate cancer associated cell invasion and there by facilitates metastatic progression. | Reference |
| LOX | Lysyl oxidase | Enzyme | Bone Metastasis | Lysyl oxidase (LOX), particularly active LOX enzyme and the 18 kDa lysyl oxidase pro-peptide (LOX-PP) plays an important role in human prostate cancer bone metastasis through stimulation of osteoblast and osteoclast differentiation. | Reference |
| SHH | Sonic hedgehog | Ligand | Bone Metastasis | Sonic hedgehog (SHH), secreted by bone metastatic human prostate cancer cell induces osteoblast differentiation which in turn stimulates bone metastatic progression. | Reference |
| LGALS1 | Galectin 1 | Ligand | Bone Metastasis | Galectin-1 (LGALS1), secreted by prostate tumor cell and is involved in prostate cancer bone metastasis through inducing osteoblasts proliferation and differentiation. | Reference |
| ETS1 | ETS proto-oncogene 1 | Transcription Factor | Bone Metastasis | ETS proto-oncogene 1 (ETS1), a transcription factor released from hormone refractory prostate tumor cell and mediates prostate cancer bone metastasis through promoting osteoblast differentiation. | Reference |
| FGF8 | Fibroblast growth factor 8 | Growth Factor | Bone Metastasis | Fibroblast growth factor 8 (FGF8), released from metastatic prostate tumor cell and is associated with prostate cancer bone metastasis through promoting osteoblast differentiation. | Reference |
| CD44 | CD44 molecule | Cell Surface Receptor | Bone Metastasis | CD44 plays a role in prostate cancer bone metastatic progression through mediating interactions between prostate cancer cell and bone marrow endothelial in a E-selectin dependent manner. | Reference |
| CEA | Carcinoembryonic antigen related cell adhesion molecule 3 | Adhesion Molecule | Bone Metastasis | CEA plays an important role in prostate cancer bone metastatic progression through mediating interactions between prostate cancer cell and bone marrow endothelial in a E-selectin dependent manner. | Reference |
| PCLP | Podocalyxin like | Integral Membrane Protein | Bone Metastasis | PCLP plays an important role in prostate cancer bone metastatic progression through mediating interactions between prostate cancer cell and bone marrow endothelial in a E-selectin dependent manner. | Reference |
| MCAM | Melanoma cell adhesion molecule | Adhesion Molecule | Bone Metastasis | MCAM plays an important role in prostate cancer bone metastatic progression through mediating interactions between prostate cancer cell and bone marrow endothelial in a E-selectin dependent manner. | Reference |
| CX43 | Gap junction protein alpha 1 | Membrane Transport protein | Bone Metastasis | Gap junction protein CX43 mediates prostate cancer bone metastasis through modulation of osteoblast differentiation in bone marrow microenvironment. | Reference |
| MLCK | Myosin light chain kinase 2 | Serine/Threonine Kinase | Bone Metastasis | Activation of myosin light chain kinase (MLCK), a downstream effector of integrin-beta1 and TGF-beta2 plays a significant role in prostate cancer bone metastasis associated dormancy escape mechanism through activation of cell proliferation and cell cycle progression. | Reference |
| E2F4 | E2F transcription factor 4 | Transcription Factor | Bone Metastasis | E2F transcription factor 4 (E2F4) downregulation is critically involved with prostate cancer bone metastasis associated dormancy escape mechanisms through activation of cell proliferation and cell cycle progression. | Reference |
| CDK6 | Cyclin-dependent kinase 6 | Cell Cycle Control Protein | Bone Metastasis | Cell cycle regulator cycline dependent kinase 6 (CDK6) is significantly involved with prostate cancer bone metastasis associated dormancy escape mechanisms through activation of cell proliferation and cell cycle progression. | Reference |
| IL6R | Interleukin 6 receptor | Cytokine Receptor | Bone Metastasis | IL-6 receptor (IL6R) plays a role in prostate cancer cell proliferation in bone microenvironment through IL-6/IL6R/AR signaling axis. | Reference |
| PTHRP | Parathyroid hormone like hormone | Peptide Hormone | Bone Metastasis | Parathyroid hormone-related protein (PTHrP) plays a major role in human prostate cancer associated bone metastasis stimulation. | Reference |
| FGF9 | Fibroblast growth factor 9 | Growth Factor | Bone Metastasis | Fibroblast growth factor 9 (FGF9), secreted from bone metastatic prostate tumor cell induces osteogenesis by mediating osteoblast proliferation. | Reference |
| UPA | Plasminogen activator, urokinase | Serine Protease | Bone Metastasis | Urokinase-type plasminogen activator (UPA), secreted from osteoblasts in prostate cancer bone microenvironment mediates prostate cancer cell migration and invasion. | Reference |
| PAI1 | Serpin family E member 1 | Protease inhibitor | Bone Metastasis | Plasminogen activator inhibitor 1 (PAI1), which is induced by bone metastatic prostate tumor stroma, mediates bone metastatic prostate tumor growth and | Reference |
| UPA | Plasminogen activator, urokinase | Serine Protease | Bone Metastasis | Urokinase-type plasminogen activator (UPA), secreted from metastatic prostate tumor mediates prostate cancer cell growth in bone microenvironment. | Reference |
| CCL5 | C-C motif chemokine ligand 5 | Chemokine | Bone Metastasis | Intramedullary pressure generated by metastatic prostate tumour in bone microenvironment induces osteocytes to release CCL5 which in turn mediates intraosseous prostate tumour growth. | Reference |
| MMP9 | Matrix metallopeptidase 9 | Metallo Protease | Bone Metastasis | Intramedullary pressure generated by metastatic prostate tumour in bone microenvironment induces osteocytes to release matrix mettaloprotease 9 (MMP9) which in turn mediates intraosseous prostate tumour growth. | Reference |
| MMP2 | Matrix metallopeptidase 2 | Metallo Protease | Bone Metastasis | Intramedullary pressure generated by metastatic prostate tumour in bone microenvironment induces osteocytes to release matrix mettaloprotease 2 (MMP2) which in turn mediates intraosseous prostate tumour growth. | Reference |
| DKK1 | Dickkopf WNT signaling pathway inhibitor 1 | Ligand | Bone Metastasis | Dickkopf homolog 1 (DKK-1), a osteolytic metastasis promoting factor is released by prostate cancer cell and is significantly involved in bone remodelling in prostate tumour bone microenvironment. | Reference |
| MAOA | Monoamine oxidase A | Enzyme: Oxidase | Bone Metastasis | Monoamine oxidase A (MAOA), a clinically and functionally important mediator of prostate cancer bone and visceral metastases, activates paracrine SHH signaling in prostate tumour bone microenvironment, which in turn induces osteoclastogenesis, osteoblast proliferation and signaling. | Reference |
| MCP1 | Monocyte chemotactic protein 1 | Chemokine | Bone Metastasis | Monocyte chemotactic protein 1 (MCP-1), a osteoclastogenic factor is secreted from both osteolytic prostate cancer cells and osteoblasts in prostate cancer bone microenvironment and induces osteoclastogenesis, osteoblast proliferation and signaling. | Reference |
| IGFBP5 | Insulin like growth factor binding protein 5 | Adhesion Molecule | Bone Metastasis | Insulin-like growth factor binding protein 5 (IGFBP-5), a osteoclastogenic factor is secreted from both osteolytic prostate cancer cells and osteoblasts in prostate cancer bone microenvironment and induces osteoclastogenesis, osteoblast proliferation and signaling. | Reference |
| RANKL | Receptor activator of NF-?-B ligand | Ligand | Bone Metastasis | Receptor activator of NF-?-B ligand (RANKL), a osteoclastogenic factor is secreted from osteolytic prostate cancer cells in prostate cancer bone microenvironment and induces osteoclastogenesis and bone destruction. | Reference |
| CTSL | Cathepsin L | Cysteine protease | Bone Metastasis | Cathepsin L (CatL) is a cysteine cathepsin protease that is overexpressed in prostate cancer and secreted by metastatic prostate cancer tumour in bone microenvironment and induces osteoclast proliferation and activation. | Reference |
| SNAIL | Snail family zinc finger 1 | Transcription Regulatory Protein | Bone Metastasis | SNAIL, a transcription factor plays a role in prostate cancer bone metastasis by stimulating Cathepsin L synthesis through JAK2/STAT3/SNAIL signaling axis. | Reference |
| ITGB1 | Integrin subunit beta 1 | Cell Surface Receptor | Bone Metastasis | Beta1 integrin (ITGB1), plays a role in human prostate cancer bone metastasis through non canonical activation of sonic hedgehog signaling by PI3K/AKT signaling pathway. | Reference |
| TGFB2 | Transforming growth factor beta 2 | Growth Factor | Bone Metastasis | Metastatic prostate tumour and osteoblast interections in bone microenvironment induces TGFB2, which plays a role in bone remodeling. | Reference |
| TWEAK | TNF superfamily member 12 | Ligand | Bone Metastasis | TWEAK, a TNF-like cytokine plays a vital role in prostate tumour bone metastasis through regulation of cell survival and proliferation. | Reference |
| TNFRSF12A | TNF receptor superfamily member 12A | Cell Surface Receptor | Bone Metastasis | FN14 (TNFRSF12A), a TNF receptor family member plays an important role in prostate tumour bone metastasis through regulation of cell survival and proliferation in response of TWEAK mediated activation. | Reference |
| NDRG1 | N-myc downstream regulated 1 | Unclassified | Bone Metastasis | NDRG1 (N-myc downstream-regulated gene 1) plays a very critical role in induction of dormancy in prostate cancer stem like cell within bone metastatic prostate cancer microenvironment through activation of BMP7/BMPR2/P38/NDRG1 signaling axis. | Reference |
| BMP7 | Bone morphogenetic protein 7 | Ligand | Bone Metastasis | BMP7 (bone morphogenetic protein 7), which is secreted from bone stromal cells, induces dormancy in prostate cancer stem like cell within bone metastatic prostate cancer microenvironment through activation of BMP7/BMPR2/P38/NDRG1 signaling axis. | Reference |
| MTOR | Mechanistic target of rapamycin kinase | Cell Cycle Control Protein | Bone Metastasis | Mammalian target of rapamycin (mTOR) inhibition by TBK1 plays arole in induction of metastatic dormancy in prostate cancer bone microenvironment. | Reference |
| TBK1 | TANK binding kinase 1 | Serine/Threonine Kinase | Bone Metastasis | TANK binding kinase 1 (TBK1) is a noncanonical I?B kinase (IKK) family member critically mediates metastatic dormancy in prostate cancer bone microenvironment through inhibition of MTOR. | Reference |
| NFKB1 | Nuclear factor kappa B subunit 1 | Transcription Factor | Bone Metastasis | NF-kB1 plays a role in bone metastatic prostate cancer cell proliferation and invasion through activation of CXCL-12/CXCR4/NF-kB signaling pathway. | Reference |
| SELE | Selectin E | Adhesion Molecule | Bone Metastasis | E selectin in bone endothelium plays a very important role in adhesion of metastatic prostate cancer cell in bone microenvironment. | Reference |
| FN1 | Fibronectin 1 | Extracellular Matrix Protein | Bone Metastasis | Fibronectin1 is involved with bone metastatic prostate cancer associated dormancy escape mechanism through activation of ITGB1/MLCK/CDK6 signaling. | Reference |
| TGFBI | Transforming growth factor beta induced | Ligand | Bone Metastasis | Transforming growth factor-beta -induced protein (TGFBI) plays a significant role in prostate cancer bone metastasis in response of androgen deprivation therapy (ADT). | Reference |
| CXCL5 | C-X-C motif chemokine ligand 5 | Chemokine | Bone Metastasis | Myeloid phagocytic clearance of apoptotic cancer cells triggers CXCL5 induced STAT3 and NF-kB signaling activation, which plays an important role in cell growth during bone metastatic prostate cancer progression. | Reference |
| FBXL4 | F-box and leucine rich repeat protein 4 | Ubiquitin proteasome system protein | Bone Metastasis | FBXL4 (F-box and leucine rich repeat protein 4) plays a critical regulatory role during the progression of bone metastatic prostate cancer. | Reference |
| FZD8 | Frizzled class receptor 8 | G protein coupled receptor | Bone Metastasis | FZD8 (Frizzled class receptor 8), a P53 regulated protein promotes human prostate cancer bone metastasis by activation of cannonical Wnt/Beta-catenine mediated signaling. | Reference |
| TNC | Troponin C type 1 (slow) | Calcium Binding Protein | Bone Metastasis | Tenascin-C (TNC), a part of prostate cancer reactive stroma, plays a very crucial role in initiation of prostate cancer bone metastasis by mediating interactions of prostate cancer cells with bone microenvironment. | Reference |