| Protein | Protein Name | Molecular Type | Feature | Evidence | Reference |
|---|
| E2F1 | E2F transcription factor 1 | Transcription Factor | Aoptosis Resistance | E2F1 is involved in the resistance to drug induced apoptosis through regulation of EGR1 transcription factor. | Reference |
| MYC | V-myc avian myelocytomatosis viral oncogene homolog | Transcription Factor | Chemoresistance | c-Myc mediated signaling play an important role in docitaxel resistance in prostate cancer. | Reference |
| MYC | V-myc avian myelocytomatosis viral oncogene homolog | Transcription Factor | Chemoresistance | Hexosamine biosynthetic pathway (HBP) through O-linked beta-N-acetylglucosamine transferase (OGT) regulates the stability of c-MYC in prostate cancer. | Reference |
| TP53 | Tumor protein p53 | Transcription Factor | Aoptosis Resistance | It is involved in the resistance to apoptotic cell death in both androgen dependent & independent prostate cancer cell line. | Reference |
| RUNX2 | Runt-related transcription factor 2 | Transcription Factor | Aoptosis Resistance | RUNX2 is involved in apoptosis resistance of prostate cancer by modulating expressiopn of BCL2. | Reference |
| BCL2 | B-cell CLL/lymphoma 2 | Adaptor Protein | Apoptosis Evasion | MicroRNA-15 and MicroRNA-16-1 function as tumor suppressor by targeting BCL2 oncogene and these microRNAs are frequently deleted in prostate cancer | Reference |
| BCL2 | B-cell CLL/lymphoma 2 | Adaptor Protein | Apoptosis Evasion | MicroRNA-205 is a regulator of anti apoptotic protein BCL2 and is downregulated in prostate cancer | Reference |
| HTRA2 | HtrA serine peptidase 2 | Serine Protease | Modulation of Cell Death Mechinery | High temperature requirement A2 (HTRA2), a serine protease iteracts with tumour suppressor ITGA7 and induce prostate cancer apoptosis. ITGA7 expression is repressed in prostate cancer through either mutation ar downregulation. | Reference |
| HTRA2 | HtrA serine peptidase 2 | Serine Protease | Modulation of Cell Death Mechinery | HTRA2 is involved in apoptosis regulation in prostate cancer. | Reference |
| SOCS3 | Suppressor of cytokine signaling 3 | Adaptor Protein | Aoptosis Resistance | SOCS3 antagonize and influence TRAIL and resveratrol mediated apoptosis in prostate cancer cell line DU145 cells. | Reference |
| BAK1 | BCL2-antagonist/killer 1 | Adaptor Protein | Apoptosis Evasion | BAK1 is a proapoptotic regulator and is inhibited by the miR-125b which functions as an oncogene in prostate cancer | Reference |
| BAK1 | BCL2-antagonist/killer 1 | Adaptor Protein | Apoptosis Evasion | Endothelin1 decreased the expression of BAK1 in prostate cancer | Reference |
| BIN1 | Bridging integrator 1 | Adaptor Protein | Apoptosis Evasion | BIN1 is a proapoptotic molecule that can regulate prostate cancer progression and is frequently inactivated in prostate cancer | Reference |
| BCL2L2 | BCL2-like 2 | Adaptor Protein | Chemoresistance | Mediates resistance to chemotherapy induced apoptosis in androgen dependent & independent prostate cancer cell line; it is targeted by miR-205 and miR-31. | Reference |
| FHL2 | Four and a half LIM domains 2 | Adaptor Protein | Apoptosis Evasion | It inhibits FOXO1 activity & there by suppresses the genes involved in apoptosis in both androgen dependent & independent prostate cancer cell line. | Reference |
| HRK | Harakiri, BCL2 interacting protein | Adaptor Protein | Modulation of Cell Death Mechinery | HRK promotes tumour progression in prostate cancer by modulating cell death machinery | Reference |
| TRADD | TNFRSF1A-associated via death domain | Adaptor Protein | Aoptosis Resistance | androgen change the TRADD/RIP1 ratio, which results in the NF-kappaB activation and sequentially blocks TRAIL-induced apoptosis mechinery | Reference |
| TRADD | TNFRSF1A-associated via death domain | Adaptor Protein | Aoptosis Resistance | Androgen deprivation therapy results in the rising of TNF-alpha resistance by reducing TRADD expression during prostate cancer development | Reference |
| CFLAR | CASP8 and FADD-like apoptosis regulator | Adaptor Protein | Aoptosis Resistance | It is directly targeted by AR and is involved in regulation of Fas/FasL mediated apoptosis: plays a role in apoptosis inhibition in androgen dependent prostate cancer cell line. | Reference |
| BECN1 | Beclin 1, autophagy related | Adaptor Protein | Autophagy | It is an important regulator of autophagy in prostate cancer & its allelic loss occur at high frequency in prostate cancer. | Reference |
| BIRC6 | Baculoviral IAP repeat containing 6 | Adaptor Protein | Chemoresistance | BIRC6 is involved in Therapeutic resistance and contributes towards prostate cancer progression | Reference |
| FADD | Fas (TNFRSF6)-associated via death domain | Adaptor Protein | Aoptosis Resistance | It is involved in in PTEN mediated apoptosis for both death receptor mediated & drug induced apoptosis in androgen dependent prostate cancer cell line: plays a role in apoptosis resistance & chemoresistance due to PTEN loss of function. | Reference |
| TGFBR2 | Transforming growth factor, beta receptor II | Receptor Serine/threonine Kinase | Aoptosis Resistance | During endothelial & perineural Cell Invasion TGF beta mediated enhanced secretion of CAV1 into the tumor microenvironment causes marked inhibition of prostate cancer apoptosis | Reference |
| TGFBR2 | Transforming growth factor, beta receptor II | Receptor Serine/threonine Kinase | Aoptosis Resistance | Overexpression of BCL2 leads to androgen independent prostate cancer by resistance of TGF beta mediated apoptosis | Reference |
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase | Aoptosis Resistance | BMP9 function as apoptosis regulator and BMPR2 is required for its function in prostate cancer. | Reference |
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase | Modulation of Cell Death Mechinery | BMP9 function as apoptosis regulator and BMPR2 is required for its function in prostate cancer. | Reference |
| PDGFRB | Platelet-derived growth factor receptor, beta polypeptide | Receptor Tyrosine Kinase | Aoptosis Resistance | PDGFRB upregulates MCL1 through HIF1alpha and beta catenine mediated signaling and MCL1 is involved in docetaxel resistance in metastatic prostate cancer. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | Apoptosis Evasion | EGFR shows an important role in anoikis resistance in metastatic prostate cancer along with SRC. | Reference |
| PHB | Prohibitin | Adaptor Protein | Aoptosis Resistance | Prohibitin(PHB) is involved in TGF beta mediated apoptosis in prostate cancer cell in both Smad dependent and Smad independent way. | Reference |
| NGFR | Nerve growth factor receptor | Cell Surface Receptor | Apoptosis Evasion | It is involved in intrinsic apoptosis cascade & its loss of expression is associated with apoptosis evasion in androgen independent prostate cancer cell line. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Radioresistance | androgen receptor signaling transcriptionally upregulates a large subset of DNA repair genes, thereby enhancing the repair capacity and promoting radioresistance of prostate cancer | Reference |
| AR | Androgen receptor | Nuclear Receptor | Chemoresistance | It is critically involved in multidrug resistance including docetaxel resistance in prostate cancer through crosstalking with Twist1/YB-1 signalling. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Modulation of Cell Death Mechinery | AR enhance prostate cancer progression by differential modulation of various cell deaths including apoptosis, anoikis, entosis, necrosis, and autophagic cell deaths | Reference |
| MAPK14 | Mitogen-activated protein kinase 14 | Serine/Threonine Kinase | Aoptosis Resistance | MAPK14(p38 alpha) imparts resistance to TNF alpha induced apoptosis in LNCaP prostate cancer cell line. | Reference |
| PRKCA | Protein kinase C, alpha | Serine/Threonine Kinase | Chemoresistance | It plays a role in the development of cisplatin resistance through stabilization of BCL2 in both androgen dependent & independent prostate cancer cell line. | Reference |
| PRKCE | Protein kinase C, epsilon | Serine/Threonine Kinase | Aoptosis Resistance | PRKCE is associated with resistance to apoptosis in prostate cancer as PRKCE overexpression shows apoptotic resistance in transgenic mice. | Reference |
| PIM2 | Pim-2 oncogene | Serine/Threonine Kinase | Aoptosis Resistance | PIM2 is involved in the apoptosis resistance in prostate cancer tissues and cell line DU-145 through phosphorylation of eIF4B. | Reference |
| SRC | V-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog | Tyrosine Kinase | Aoptosis Resistance | SRC is involved in apoptosis resistance in prostate cancer cell through P2Y2/Src/p38/COX-2 pathway. | Reference |
| PYCARD | PYD and CARD domain containing | Adaptor Protein | Aoptosis Resistance | PYCARD(TMS1/ASC) a proapoptotic gene is silenced during prostate tumorigenesis in a promoter methylation dependent manner. | Reference |
| CFLAR | CASP8 and FADD-like apoptosis regulator | Adaptor Protein | Aoptosis Resistance | It functions as a key regulator of androgen deprivation therapy response & mediates castration resistance: confers resistance of metastatic CaP cells to docetaxel, TRAIL, and oxaliplatin. | Reference |
| SOCS3 | Suppressor of cytokine signaling 3 | Adaptor Protein | Apoptosis Evasion | It mediates regulation of apoptosis & its function has been implicated in the cell survival machinery of both androgen dependent & independent prostate cancer cell line; it is overexpressed in castration resistant tumour. | Reference |
| BCL2 | B-cell CLL/lymphoma 2 | Adaptor Protein | Chemoresistance | It is overexpressed in 70% of androgen independent prostate cancer: contributes to prostate cancer chemoresistance. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Chemoresistance | It mediates enzalutamide resistance through NF-?B2/p52 signaling in androgen dependent prostate cancer cell line. | Reference |
| PIAS1 | Protein inhibitor of activated STAT, 1 | Cell Cycle Control Protein | Chemoresistance | PIAS1, a cytokine signaling modulator and cell cycle regulator which is overexpressed in local and metastatic prostate cancer, plays a critical role in docetaxel resistance and docetaxel resistant cell survival in human prostate cancer. | Reference |
| CXCR4 | Chemokine (C-X-C motif) receptor 4 | G protein Coupled Receptor | Chemoresistance | CXCL12/CXCR4 signaling axis is critically involved in the acquisition of docetaxel resistance in human prostate cancer cell through PAK4-dependent activation of LIMK1. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | Chemoresistance | Epidermal growth factor receptor (EGFR), which is overexpressed in human prostate cancer, plays a role in the promotion of docetaxel resistance in castration resistant prostate cancer (CRPC) cell through AKT dependent expression of MDR1. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Radioresistance | PI3K/AKT1/mTOR, the most frequently activated signaling pathways in prostate cancer, plays a very important role in the acquisition of radiation resistance in prostate cancer cell. | Reference |
| GSK3B | Glycogen synthase kinase 3 beta | Serine/Threonine Kinase | Autophagy | Glycogen synthase kinase 3 beta, a multi-functional protein kinase regulates autophagy in human prostate cancer cell through modulation of LKB1-AMPK pathway. | Reference |
| DAXX | Death-domain associated protein | Adaptor Protein | Autophagy | Adaptor protein DAXX promotes human prostate tumorigenesis through suppression of autophagy and it has been supported by a tumor xenograft model. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Autophagy | Beta catenine (CTNNB1), a key signaling component in Wnt signaling pathway, plays a critical role in the inhibition of autophagy in human prostate cancer cell through nuclear accumulation in response of nitric oxide (NO). | Reference |
| DAB2IP | DAB2 interacting protein | Ras GTPase-activating protein | Chemoresistance | Its loss of expression contributes to docetaxel resistance in androgen dependent prostate cancer cell line. | Reference |
| DAB2IP | DAB2 interacting protein | Ras GTPase-activating protein | Radioresistance | Loss of DAB2IP imparts prostate cancer cells to ionizing radiation resistance in androgen independent prostate cancer cell line. | Reference |
| DAB2IP | DAB2 interacting protein | Ras GTPase-activating protein | Autophagy | It has a role in suppression of autophagy in androgen dependent & independent prostate cancer cell line. | Reference |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 | Extracellular Matrix Protein | Apoptosis Evasion | EFEMP1 inactivation through promoter methylation, plays a role in evassion of apoptotic program in human prostate cancer cell. | Reference |
| DAB2IP | DAB2 interacting protein | Ras GTPase-activating protein | Apoptosis Evasion | DAB2IP, an important tumour suppressor which is lost during the progression of prostate cancer, reprograms intracellular signal transduction and inhibits prostate cancer apoptosis. | Reference |
| MCL1 | Myeloid cell leukemia 1 | Chaperone | Apoptosis Evasion | MCL-1, an anti-apoptotic protein which is highly expressed in human prostate cancer, mediates prostate cancer cell death resistance in response of chemotherapeutic agents. | Reference |
| ADAM10 | ADAM metallopeptidase domain 10 | Metallo Protease | Aoptosis Resistance | ADAM10, a matrix metallo protease contributes apoptosis resistance of human prostate cancer cell by hydrolizing FASL through TNFA/p38-MAPK/NF-kB signaling pathways. | Reference |
| BLT2 | Leukotriene B4 receptor 2 | G protein Coupled Receptor | Aoptosis Resistance | Leukotriene B4 receptor-2 (BLT2) mediates a very critical role in human prostate cancer associated anikis resistance through BLT2-NOX-ROS-NF-?B signaling pathways. | Reference |
| PRDX3 | Peroxiredoxin 3 | Enzyme | Aoptosis Resistance | Peroxiredoxin-3 (PRDX-3), plays a role in imparting apoptosis resistance in prostate cancer cell against oxidation induced apoptosis. | Reference |
| DAB2IP | DAB2 interacting protein | Ras GTPase-activating protein | Radioresistance | DAB2IP, a potential tumor suppressor gene, is targeted by MiR-32 (overexpressed in human prostate cancer) and mediates radiation resistance in prostate cancer patially through suppression of autophagy related pathways. | Reference |
| DAB2IP | DAB2 interacting protein | Ras GTPase-activating protein | Autophagy | DAB2IP, a potential tumor suppressor gene which is largely inactivated in human prostate cancer, plays a very critical role in suppression of autophagy pathways in prostate cancer and in these context, MiR-32 overexpressed in human prostate cancer and mediates an important regulatory role. | Reference |
| OPN | Osteopontin | Adhesion Molecule | Chemoresistance | Osteopontin (OPN), a phosphoprotein plays a role in mediating docetaxel resistance in PC3 prostate cancer cell through its splice variants. | Reference |
| ABCB1 | ATP binding cassette subfamily B member 1 | Transport Protein | Chemoresistance | ABCB1, a transporter plays a very important role in the acquisition of docetaxel resistance in human prostate cancer cell. | Reference |
| PRKAR2A | Protein kinase, cAMP-dependent, regulatory subunit type II alpha | Serine/Threonine Kinase | Chemoresistance | PRKAR2A, a type II-alpha regulatory subunit of protein kinase A, modulates taxol resistance in human prostate cancer cell. | Reference |
| ERG | v-ets avian erythroblastosis virus E26 oncogene homolog | Transcription Factor | Chemoresistance | ERG, a product of the ETS gene rearrangement in prostate cancer, plays a very crucial role in cabazitaxel and docetaxel resistance in human prostate cancer. | Reference |
| NR2C2 | Nuclear receptor subfamily 2 group C member 2 | Nuclear Receptor | Chemoresistance | Testicular nuclear receptor 4 (TR4) or NR2C2 plays a role in driving docetaxel resistance in castration resistant prostate cancer (CRPC). | Reference |
| NOTCH1 | Notch 1 | Cell Surface Receptor | Chemoresistance | NOTCH1 mediated signaling plays an essential role in mediating chemoresistance in prostate cancer stem cell (are believed to be the origin of cancer recurrence following therapy intervention) through regulation of ABCC1 expression. | Reference |
| PIM1 | Pim-1 proto-oncogene, serine/threonine kinase | Serine/Threonine Kinase | Chemoresistance | PIM1 kinase, a serine/threonine kinase that is overexpressed in human prostate cancer, is involved in the development of docetaxel resistance in castration resistant prostate cancer cell. | Reference |
| ARRB1 | Arrestin, beta 1 | Adaptor Protein | Chemoresistance | IL6 plays a role in docetaxel resistance in castration resistant prostate cancer (CRPC). | Reference |
| LDH5 | Lactate Dehydrogenase 5 | Enzyme | Radioresistance | Lactate Dehydrogenase 5 isoenzyme, which is overexpressed in human prostate cancer, plays a role in promotion of radiation resistance in human prostate cancer cell. | Reference |
| TNK2 | Tyrosine kinase, non-receptor, 2 | Tyrosine Kinase | Radioresistance | ACK1 tyrosine kinase (TNK2), plays a critical role in driving radiation resistance in castration resistant prostate cancer (CRPC) cell through ACK1/AR/ATM signaling. | Reference |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | Transcription Factor | Radioresistance | RELB, a NF-kappaB pathway component plays a very significant role in the development of radiation resistance in human prostate cancer cell through regulation of manganese superoxide dismutase gene. | Reference |
| SOD2 | Superoxide dismutase 2 | Enzyme | Radioresistance | The antioxidant enzyme manganese superoxide dismutase (SOD2) is involved in the promotion of radiation resistance in human prostate cancer cell. | Reference |
| COX2 | Prostaglandin-endoperoxide synthase 2 | Enzyme | Radioresistance | Cyclooxygenase-2 is involved in mediating radiation resistance in human prostate adenocarcinoma cell. | Reference |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | Unclassified | Autophagy | GABA(A) receptor-associated protein like 1 (GABARAPL1), a ubiquitin-like modifier which is transcriptionally regulated by androgen receptor (AR), plays a role in suppression of autophagy. | Reference |
| CD147 | Basigin (Ok blood group) | Cell Surface Receptor | Autophagy | CD147 is involved in the modulation of autophagy through the PI3K/AKT1/mTOR pathway in human prostate cancer cell. | Reference |