| Protein | Protein Name | Molecular Type | Feature | Evidence | Reference |
|---|
| LRP6 | low density lipoprotein receptor-related protein 6 | Structural Protein | Metabolic Reprogramming | LRP6 along with CAV1 acivates IGF1R/IR mediated signaling and stimulates aerobic glycolysis in prostate cancer cells. | Reference |
| PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta | Lipid Kinase | Metabolic Reprogramming | PIK3CB is involved in the metabolic regulation and glucose homeostasis in mouse prostate tumour model through a kinase independent mechanism. | Reference |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | Adaptor Protein | Metabolic Reprogramming | DAB2 along with Megalin plays an essential role in the transport of Vidamin D 25-hydroxycholecalciferol (25D3)-vitamin D binding protein (DBP) complex in prostate cancer cells. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Metabolic Reprogramming | AR regulates liver X receptor(LXR) activity and thereby mediates cholesterol accumulation in prostate cancer cell. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Metabolic Reprogramming | AR-AMPK-PGC-1alpha signaling cascade mediates mitochondrial biogenesis in prostate cancer cell and consequently effects prostate cancer cell growth along with metabolic reprogramming | Reference |
| AR | Androgen receptor | Nuclear Receptor | Metabolic Reprogramming | AR promotes prostate cancer metabolic reprogramming by influencing pentose phosphate pathway in prostate cancer through mammalian target of rapamycin (mTOR)-mediated upregulation of glucose-6-phosphate dehydrogenase (G6PD). | Reference |
| AR | Androgen receptor | Nuclear Receptor | Metabolic Reprogramming | AR plays a cetralmost role in prostate cancer metabolic reprogramming through upregulation of glucose uptake and glycolysis(GLUT1, HK1/2 and PFKFB2) and lipid biosynthetic pathways(FASN and ACACA). | Reference |
| AR | Androgen receptor | Nuclear Receptor | Metabolic Reprogramming | AR along with JunD mediates an oxidative stress(ROS) generation pathway in prostate cancer and thereby promotes metabolic reprogramming through polyamine oxidation. | Reference |
| PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | Adaptor Protein | Metabolic Reprogramming | PI3K/AKT pathway plays an essential leading role in enhancing HIF1A expression in prostate cancer, which is a master transcription factor and inherently associated with prostate cancer warburg effect. | Reference |
| PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | Adaptor Protein | Metabolic Reprogramming | PI3K/AKT pathway activation, due to inactivation of PTEN tumour suppressor, play an important role in overexpression of fatty acid synthase (FAS) in prostate cancer, which is the key metabolic enzyme in the synthesis of long chain saturated fatty acids. | Reference |
| PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | Adaptor Protein | Metabolic Reprogramming | PI3K/AKT pathway activates bifunctional enzyme PFKFB2, which plays a critical role in glucose uptake and glucose-dependent lipid synthesis in human prostate cancer. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | Metabolic Reprogramming | Activation of the AKT-mTORC1-4EBP1 axis, due to inactivation of PTEN tumour suppressor, mediates prostate cancer warburg effects by enhancing hexokinase 2 (HK2) expression. | Reference |
| MYC | V-myc avian myelocytomatosis viral oncogene homolog | Transcription Factor | Metabolic Reprogramming | Hexosamine biosynthetic pathway (HBP) modulates c-MYC stability, which plays a leading role in prostate cancer metabolic reprogramming. | Reference |
| MYC | V-myc avian myelocytomatosis viral oncogene homolog | Transcription Factor | Metabolic Reprogramming | Sphingosine kinase 1(SK1) enhances c-MYC stability, whicg is essentially involved in prostate cancer warburg effect and cell survival. | Reference |
| MYC | V-myc avian myelocytomatosis viral oncogene homolog | Transcription Factor | Metabolic Reprogramming | c-MYC activates metabolic sensor AMPK and thereby enhances glycolysis and consequently promotes metabolic reprogramming in prostate cancer. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Metabolic Reprogramming | CTNNB1 plays a very important role in prostate cancer metabolic reprogramming by regulating the expression of HIF1A, which is a master transcription factor and inherently associated with prostate cancer warburg effect. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Metabolic Reprogramming | Fatty acid synthase (FASN), a key metabolic enzyme for liponeogenesis and overexpressed in prostate cancer, stabilizes cytoplasmic CTNNB1, which plays a leading role in prostate cancer metabolic reprogramming. | Reference |
| CAV1 | Caveolin 1, caveolae protein, 22kDa | Structural Protein | Metabolic Reprogramming | CAV1 plays an essential role in stimulating Akt-mTORC1 mediated signaling and thereby enhancing aerobic glycolysis in prostate cancer. | Reference |
| IL6 | Interleukin 6 | Cytokine | Metabolic Reprogramming | Nuclear accumulation of adaptor protein ARRB1 enhances psudohypoxia and metabolic reprogramming in prostate cancer; additionally it also regulates the expression of HIF1A, which is a master transcription factor and inherently associated with prostate cancer warburg effect. | Reference |
| SLC2A1 | Solute carrier family 2 (facilitated glucose transporter), member 1 | Transport protein | Metabolic Reprogramming | SLC2A1(GLUT1), a glucose transporter that is highly expressed in advanced prostate cancer, plays an essential role in uptake of glucose in prostate cancer cells and there by fuels metabolic reprogramming and cell proliferation. | Reference |
| KLF5 | Kruppel-like factor 5 (intestinal) | Transcription Factor | Metabolic Reprogramming | KLF5, a zinc-finger transcription factor plays an important role in prostate cancer metabolic reprogramming through androgen dependent stimulation of fatty acid synthase(FASN). | Reference |
| TRPM7 | Transient receptor potential cation channel, subfamily M, member 7 | Ion channel | Metabolic Reprogramming | Ion channel TRPM7 mediates prostate cancer metabolic reprogramming through activation of AKT. | Reference |
| KLHL20 | Kelch like family member 20 | Adaptor protein | Metabolic Reprogramming | Adaptor protein KLHL20, a Cullin3 (Cul3) substrate, plays an essential leading role in prostate cancer metabolic reprogramming through degradation of tumour suppressor PML. | Reference |
| ELOVL7 | ELOVL fatty acid elongase 7 | Unclassified | Metabolic Reprogramming | ELOVL7, which is overexpressed in prostate cancer and plays a role in prostate cancer metabolic reprogramming through elongation of saturated very-long-chain fatty acids. | Reference |
| HK2 | Hexokinase 2 | Enzyme | Metabolic Reprogramming | Hexokinase 2 (HK2) functions a critical role in prostate cancer metabolic reprogramming through enhancement of warburg effect. | Reference |
| SPHK1 | Sphingosine kinase 1 | Lipid kinase | Metabolic Reprogramming | Sphingosine kinase1(SPHK1) plays a role in prostate cancer metabolic reprogramming through enhancement of c-MYC stability. | Reference |
| ABCA1 | ATP binding cassette subfamily A member 1 | Transport Protein | Metabolic Reprogramming | ABCA1, a cholesterol transporter which suffers from loss of expression during prostate cancer progression, functions a very important role in prostate cancer metabolic reprogramming through cholesterol accumulation. | Reference |
| SLC16A4 | Solute carrier family 16, member 4 | Transport Protein | Metabolic Reprogramming | Monocarboxylate transporter (MCT4) plays a critical role in prostate cancer metabolic reprogramming through mediating reverse warburg effect. | Reference |
| NR1H3 | Nuclear receptor subfamily 1 group H member 3 | Nuclear Receptor | Metabolic Reprogramming | Liver X receptor LXR(NR1H3) is significantly associated with prostate cancer metabolic reprogramming through mediating cholesterol homeostasis. | Reference |
| ACO2 | Aconitase 2, mitochondrial | Enzyme | Metabolic Reprogramming | Mitochondrial aconitase 2 (ACO2), which is induced by hypoxia, plays a role in prostate cancer metabolic reprogramming through mediating a central most role in carbohydrate metabolism. | Reference |
| FASN | Fatty acid synthase | Enzyme | Metabolic Reprogramming | Fatty acid synthase (FASN), which is overexpressed in human prostate cancer, is significantly associated with prostate cancer metabolic reprogramming through enhancement of lipogenesis. | Reference |
| CTNND2 | Catenin delta 2 | Adhesion Molecule | Metabolic Reprogramming | Delta catenin plays a critical role in prostate cancer metabolic reprogramming through modulation of beta catenin and HIF1A mediated signaling. | Reference |