| Protein | Protein Name | Molecular Type | Feature | Evidence | Reference |
|---|
| TGFBR2 | Transforming growth factor, beta receptor II | Receptor Serine/threonine Kinase | Immune Evasion | Over-expression of TGF-beta aids tumorigenesis by not only stimulating angiogenesis and suppressing the immune system, but also by acting directly on the prostate tumor cells | Reference |
| IFNAR1 | Interferon (alpha, beta and omega) receptor 1 | Cytokine Receptor | Immune Evasion | IFNAR1 is involved in immune surveillence in prostate cancer as IFN-alpha receptor 1 (IFNAR1)(-/-) mice exhibited reduced tumor surveillance | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | Immuno Suppression | Activation of STAT3 mediated signaling plays a crucial role in immune suppression in prostate cancer associated tumour microenvironment. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Immuno Suppression | Androgen receptor plays an important role in the inhibition of CD4+T cell to Th1 differentiation and there by promotes immunosuppression in prostate tumour associated microenvironment. | Reference |
| LGALS3BP | Lectin, galactoside-binding, soluble, 3 binding protein | Extracellular Matrix Protein | Immune Evasion | Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) expression is upregulated in human prostate cancer associated extracellular matrix and plays a role in immune evasion through inhibition of neutrophil activation in a SIGLEC9 dependent manner. | Reference |
| NKG2D | Killer cell lectin-like receptor subfamily K, member 1 | Cell Surface Receptor | Immune Evasion | NKG2D, an activation receptor for both Natural killer (NK) cell and CD8+T lymphocyte is downmodulated by prostate cancer secreted exosomes and there by contributes to immune escape. | Reference |
| HLA1 | Major histocompatibility complex, class I, A | MHC Complex Protein | Immune Evasion | Human leukocyte antigen class I antigens (HLA-I) is downregulated in human prostate cancer in response of EGF and TGF beta mediated signaling, which prevents presentation of antigenic peptides to cytotoxic T lymphocytes and there by facilitates immune evasion. | Reference |
| IL1A | Interleukin 1 alpha | Cytokine | Immuno Suppression | Inflammatory cytokine IL1A plays a role in immune suppression by mesenchymal stem cell and there by promotes prostate tumorigenesis. | Reference |
| IL18BP | Interleukin 18 binding protein | Secreted Polypeptide | Immuno Suppression | Interleukin 18 binding protein (IL-18BP), a potent inhibitor of interleukin 18 is highly secreted from human prostate tumour and plays an important role in immune modulation. | Reference |
| B7H1 | CD274 molecule | Ligand | Immune Evasion | Enhancement of B7H1 expression through activatin of PI3K pathway in human prostate cancer contributes to immunoresistance. | Reference |
| ARG1 | Arginase 1 | Enzyme | Immuno Suppression | Cytoplasmic arginase I (ARG1), which is overexpressed in human prostate tumour and plays a critical role in immuno suppression. | Reference |
| ARG2 | Arginase 2 | Enzyme | Immuno Suppression | Mitochondrial arginase II (ARG12), which is overexpressed in human prostate tumour and plays a critical role in immunosuppression. | Reference |
| NOS2 | Nitric oxide synthase 2, inducible | Unclassified | Immuno Suppression | Nitric oxide synthase (NOS2) in prostate tumour plays a very essential role in the generation of peroxynitrites (ONOO?), which causes tyrosine nitration of C8+ lymphocytes in the tumour microenvironment and inhibit its differentiation to cytotoxic T lymphocyte and there by promotes immunosuppression. | Reference |
| TGFB1 | Transforming growth factor, beta 1 | Ligand | Immuno Suppression | TGFbeta1 secreted from CD4+ T cell in human prostate tumour microenvironment inhibit differentiation of CD8+ T cells to cytotoxic T cell and there by contributes to prostate cancer immuno suppression. | Reference |
| LMP2 | Proteasome subunit beta 9 | Transcription Regulatory Protein | Immuno Suppression | LMP2, which is a component of HLA-1 Antigen Processing Machinery (APM) is downregulated in human prostate cancer cell and is associated with prostate cancer immuno suppression. | Reference |
| LMP7 | Proteasome subunit beta 8 | Ubiquitin Proteasome System Protein | Immuno Suppression | LMP7, which is a component of HLA-1 Antigen Processing Machinery (APM) is downregulated in human prostate cancer cell and is associated with prostate cancer immuno suppression. | Reference |
| TAP1 | Transporter 1, ATP-binding cassette, sub-family B | Transport Protein | Immuno Suppression | TAP1, which is a component of HLA-1 Antigen Processing Machinery (APM) is downregulated in human prostate cancer cell and is associated with prostate cancer immuno suppression. | Reference |
| TAP2 | Transporter 2, ATP-binding cassette, sub-family B | Transport Protein | Immuno Suppression | TAP2, which is a component of HLA-1 Antigen Processing Machinery (APM) is downregulated in human prostate cancer cell and is associated with prostate cancer immuno suppression. | Reference |
| IRF8 | Interferon regulatory factor 8 | Transcription Factor | Immuno Suppression | IRF-8, a member of the interferon regulatory factor family plays a very critical role in prostate tumor-induced inhibition of antigen processing and presenting function of dendritic cell and there by promotes immuno suppression. | Reference |
| B7H3 | CD276 molecule | Ligand | Immune Evasion | B7H3 is overexpressed in human prostate cancer and plays a role in prostate cancer associated immune evasion. | Reference |
| TNC | Troponin C type 1 (slow) | Calcium Binding Protein | Immuno Suppression | Tenascin-C (TNC), a component of extracellular matrix protein plays a role in the inhibition of T cell activation and there by promotes immuno suppression in prostate tumour microenvironment. | Reference |
| DIAPH3 | Diaphanous-related formin 3 | Unclassified | Immuno Suppression | Diaphanous-related formin-3 (DIAPH3), a non-canonical metastasis suppressor and critical cytoskeletal regulator is lost at high frequency in metastatic prostate cancer and is involved in suppression of macrophage proliferation through extracellular vesicle (EV) dependent MiR-125a mediated manner. | Reference |