Inter Hallmark Oncogenic Functional Connectivity Map
Shape code- Hexagon depicts Adaptor protein, Round depicts-Receptor protein and Round Rectangle depicts other types of protein (e.g. Kinase etc). Color code- Red indicates positive perturbation, Green indicates negative perturbation and Yellow indicates no reported information associated with perturbation. Positive perturbation includes overexpression, amplification, up regulation and oncogenic activation (mutational activation). Negative perturbation includes deletion, loss of expression, genomic instability, epigenetic silencing, microRNA mediated silencing, aberrant splicing and down regulation. Edge represents physical interaction between two proteins as based on Human Reference Protein Database (HRPD).
Insensitivity to Anti-Growth Signal - Self-Sufficiency in Growth Signal A prostate cancer evasion of growth suppression associated connectivity map that is also involved in sustaining proliferative signaling during prostate cancer development & progression[Source-Literature curation] |
Insensitivity to Anti-Growth Signal - Genome Instability, Mutation & Perturbation A prostate cancer evasion of growth suppression associated connectivity map that is also involved in genomic instability & mutation during prostate cancer development & progression[Source-Literature curation] |
Insensitivity to Anti-Growth Signal - Metastasis A prostate cancer evasion of growth suppression associated connectivity map that is also involved in cell invasion & metastasis during prostate cancer development & progression[Source-Literature curation] |
Insensitivity to Anti-Growth Signal - Cell Death Resistance A prostate cancer evasion of growth suppression associated connectivity map that is also involved in cell death resistanceduring prostate cancer development & progression[Source-Literature curation] |
Self-Sufficiency in Growth Signal - Tumor Promoting Inflammation A prostate cancer sustaining proliferative signaling associated connectivity map that is also involved in inflammatory response[Source-Literature curation & Panther Pathway Database] |
Self-Sufficiency in Growth Signal - Genome Instability, Mutation & Perturbation A prostate cancer sustaining proliferative signaling associated connectivity map that is also involved in genomic instability & mutation during prostate cancer development & progression[Source-Literature curation] |
Self-Sufficiency in Growth Signal - Angiogenesis A prostate cancer sustaining proliferative signaling associated connectivity map that is also involved in angiogenesis during prostate cancer development & progression[Source-Literature curation] |
Self-Sufficiency in Growth Signal - Metastasis A prostate cancer sustaining proliferative signaling associated connectivity map that is also involved in cell invasion & metastasis during prostate cancer development & progression[Source-Literature curation] |
Self-Sufficiency in Growth Signal - Cell Death Resistance A prostate cancer sustaining proliferative signaling associated connectivity map that is also involved in cell death resistance during prostate cancer development & progression[Source-Literature curation] |
Tumor Promoting Inflammation - Genome Instability, Mutation & Perturbation A prostate cancer genomic instability & mutation associated connectivity map that is also involved in inflammatory response during prostate cancer development & progression[Source-Literature curation] |
Tumor Promoting Inflammation - Angiogenesis A prostate cancer angiogenesis associated connectivity map that is also involved in inflammatory response during prostate cancer development & progression[Source-Literature curation] |
Tumor Promoting Inflammation - Metastasis A prostate cancer cell invasion & metastasis associated connectivity map that is also involved in inflammatory response during prostate cancer development & progression[Source-Literature curation] |
Tumor Promoting Inflammation - Cell Death Resistance A prostate cancer cell death associated connectivity map that is also involved in inflammatory response during prostate cancer development & progression[Source-Literature curation] |
Genome Instability, Mutation & Perturbation - Angiogenesis A prostate cancer genomic instability & mutation associated connectivity map that is also involved in angiogenesis during prostate cancer development & progression[Source-Literature curation] |
Genome Instability, Mutation & Perturbation - Metastasis A prostate cancer genomic instability & mutation associated connectivity map that is also involved in cell invasion & metastasis during prostate cancer development & progression[Source-Literature curation] |
Genome Instability, Mutation & Perturbation - Cell Death Resistance A prostate cancer genomic instability & mutation associated connectivity map that is also involved in cell death resistance during prostate cancer development & progression[Source-Literature curation] |
Angiogenesis - Metastasis A prostate cancer angiogenesis associated connectivity map that is also involved in cell invasion & metastasis during prostate cancer development & progression[Source-Literature curation] |
Angiogenesis - Cell Death Resistance A prostate cancer angiogenesis associated connectivity map that is also involved in cell death resistance during prostate cancer development & progression[Source-Literature curation] |
Metastasis - Cell Death Resistance A prostate cancer cell invasion & metastasis associated connectivity map that is also involved in cell death resistance during prostate cancer development & progression[Source-Literature curation] |