* Simulation specification file: * The percentages of all input nodes are generated randomly with noise at level 2. * Network Parameters ********************************************************************* * Iterations ************ * Number of clock ticks to execute in this experiment. * RunTime:TransientTime:TotalTime *------------------------------------------------------------------ RunTime:500:800 *Noisy Input modification *Noise:Window:Scalar Noise:50:2 * Inputs ******** *Input:name:initial/default value:random(R)/fixed(F):noisy(N)/fixed/(F):time to be introduced (changed from *initial/default value):dose (in percentage):duration of the change from default (0=1 time) (Dosages can be in multiple *intervals, separated by comma) *------------------------------------------------------------------------------------------------------ Input:ECM:False:R:N:1:0-100:1999 Input:EGF:False:R:N:1:0-100:1999 Input:ExtPump:False:R:N:1:0-100:1999 Input:alpha_q_lig:False:R:N:1:0-100:1999 Input:alpha_i_lig:False:R:N:1:0-100:1999 Input:alpha_s_lig:False:R:N:1:0-100:1999 Input:alpha_12_13_lig:False:R:N:1:0-100:1999 Input:IL1_TNF:False:R:F:1:0-5:1999 *Stress can be stimulated on its own, but if do IL1_TNF, must also do stress. Input:Stress:False:R:F:1:0-5:1999 *Mutated nodes *************** *Node is mutated to be ON or OFF and does not respond to any signal. *Mutation:ON[OFF]:input1,input2 *--------------------------------------------------------------------- *Mutation:ON:Erk * Delay nodes ************* *Receives a signal, but don't respond immediately. Specify how long to wait. *Delay:name:initial value:input:iterations to wait *--------------------------------------------------------------------- *Sustain nodes ************** *Receives a signal and then responds for some period of time regardless of *other additional inputs. *Sustain:name:initial/default value:duration:input *---------------------------------------------------------------------- * Outputs ********* *Output nodes are the end result. They just mirror their inputs. *Output:name:initial/default condition:input *---------------------------------------------------------------- Output:1_EGFR:True:EGFR