ID   HBB_HUMAN               Reviewed;         147 AA.
AC   P68871; P02023; Q13852; Q14481; Q14510; Q45KT0; Q6FI08; Q8IZI1;
AC   Q9BX96; Q9UCP8; Q9UCP9;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   10-JUN-2008, entry version 63.
DE   Hemoglobin subunit beta (Hemoglobin beta chain) (Beta-globin)
DE   [Contains: LVV-hemorphin-7].
GN   Name=HBB;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=77126403; PubMed=1019344;
RA   Marotta C., Forget B., Cohen-Solal M., Weissman S.M.;
RT   "Nucleotide sequence analysis of coding and noncoding regions of human
RT   beta-globin mRNA.";
RL   Prog. Nucleic Acid Res. Mol. Biol. 19:165-175(1976).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=81064667; PubMed=6254664; DOI=10.1016/0092-8674(80)90428-6;
RA   Lawn R.M., Efstratiadis A., O'Connell C., Maniatis T.;
RT   "The nucleotide sequence of the human beta-globin gene.";
RL   Cell 21:647-651(1980).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT LYS-7.
RX   PubMed=16175509; DOI=10.1086/491748;
RA   Wood E.T., Stover D.A., Slatkin M., Nachman M.W., Hammer M.F.;
RT   "The beta-globin recombinational hotspot reduces the effects of strong
RT   selection around HbC, a recently arisen mutation providing resistance
RT   to malaria.";
RL   Am. J. Hum. Genet. 77:637-642(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Lu L., Hu Z.H., Du C.S., Fu Y.S.;
RT   "DNA sequence of the human beta-globin gene isolated from a healthy
RT   Chinese.";
RL   Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT LOUISVILLE LEU-43.
RC   TISSUE=Blood;
RA   Kutlar F., Harbin J., Brisco J., Kutlar A.;
RT   "Rapid detection of electrophoretically silent, unstable human
RT   hemoglobin 'Louisville', (Beta; Phe 42 Leu/TTT to CTT) by cDNA
RT   sequencing of mRNA.";
RL   Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT DURHAM-N.C. PRO-115.
RC   TISSUE=Blood;
RA   Kutlar F., Abboud M., Leithner C., Holley L., Brisco J., Kutlar A.;
RT   "Electrophoretically silent, very unstable, thalassemic mutation at
RT   codon 114 of beta globin (hemoglobin Durham-N.C.) detected by cDNA
RT   sequencing of mRNA, from a Russian women.";
RL   Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT TY GARD GLN-125.
RC   TISSUE=Blood;
RA   Kutlar F., Holley L., Leithner C., Kutlar A.;
RT   "A rare beta chain variant 'Hemoglobin Ty Gard:Pro 124 Gln' found in a
RT   Caucasian female with erythrocytosis.";
RL   Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN   [8]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Kutlar A., Vercellotti G.M., Glendenning M., Holley L., Elam D.,
RA   Kutlar F.;
RT   "Heterozygote C->A beta-thalassemia mutation at the intron-2/848
RT   nucleotide of beta globin gene was detected on a Northern European
RT   (Caucasian) individual.";
RL   Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN   [9]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS VAL-7 AND SER-140.
RC   TISSUE=Blood;
RA   Kutlar F., Lallinger R.R., Holley L., Glendenning M., Kutlar A.;
RT   "A new hemoglobin, beta chain variant 'Hb S-Wake' confirmed to be on
RT   the same chromosome with hemoglobin S mutation, detected in an
RT   African-American family.";
RL   Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN   [10]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT O-ARAB.
RC   TISSUE=Blood;
RA   Kutlar F., Elam D., Glendenning M., Kutlar A., Dincol G.;
RT   "Coexistence of the hemoglobin O-Arab (Glu 121 Lys) and beta-
RT   thalassemia (intron-2; nucleotide 745 C->G) was detected in a Turkish
RT   patient.";
RL   Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
RN   [11]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Li W.J.;
RT   "Thalassaemic trait cause by C-T substitution at position -90 in
RT   proximal CACCC box of beta-globin gene in China family.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN   [12]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S.,
RA   Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W.,
RA   Korn B., Zuo D., Hu Y., LaBaer J.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [13]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Skeletal muscle;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [14]
RP   PROTEIN SEQUENCE OF 2-147.
RX   PubMed=13872627;
RA   Braunitzer G., Gehring-Muller R., Hilschmann N., Hilse K., Hobom G.,
RA   Rudloff V., Wittmann-Liebold B.;
RT   "The constitution of normal adult human haemoglobin.";
RL   Hoppe-Seyler's Z. Physiol. Chem. 325:283-286(1961).
RN   [15]
RP   PROTEIN SEQUENCE OF 33-42, AND MASS SPECTROMETRY.
RX   PubMed=1575724; DOI=10.1016/0006-291X(92)90699-L;
RA   Glaemsta E.-L., Meyerson B., Silberring J., Terenius L., Nyberg F.;
RT   "Isolation of a hemoglobin-derived opioid peptide from cerebrospinal
RT   fluid of patients with cerebrovascular bleedings.";
RL   Biochem. Biophys. Res. Commun. 184:1060-1066(1992).
RN   [16]
RP   PROTEIN SEQUENCE OF 33-42.
RA   Ianzer D., Konno K., Xavier C.H., Stoecklin R., Santos R.A.S.,
RA   de Camargo A.C.M., Pimenta D.C.;
RL   Submitted (JUN-2007) to UniProtKB.
RN   [17]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 122-147.
RX   MEDLINE=85205333; PubMed=2581851; DOI=10.1016/0378-1119(85)90093-9;
RA   Lang K.M., Spritz R.A.;
RT   "Cloning specific complete polyadenylylated 3'-terminal cDNA
RT   segments.";
RL   Gene 33:191-196(1985).
RN   [18]
RP   BISPHOSPHOGLYCERATE BINDING.
RX   PubMed=4555506; DOI=10.1038/237146a0;
RA   Arnone A.;
RT   "X-ray diffraction study of binding of 2,3-diphosphoglycerate to human
RT   deoxyhaemoglobin.";
RL   Nature 237:146-149(1972).
RN   [19]
RP   ACETYLATION AT LYS-145.
RX   PubMed=4531009;
RA   Shamsuddin M., Mason R.G., Ritchey J.M., Honig G.R., Klotz I.M.;
RT   "Sites of acetylation of sickle cell hemoglobin by aspirin.";
RL   Proc. Natl. Acad. Sci. U.S.A. 71:4693-4697(1974).
RN   [20]
RP   GLYCATION AT VAL-2.
RX   MEDLINE=78138698; PubMed=635569;
RA   Bunn H.F., Gabbay K.H., Gallop P.M.;
RT   "The glycosylation of hemoglobin: relevance to diabetes mellitus.";
RL   Science 200:21-27(1978).
RN   [21]
RP   GLYCATION AT LYS-9; LYS-18; LYS-67; LYS-121 AND LYS-145, AND ABSENCE
RP   OF GLYCATION AT LYS-60; LYS-83 AND LYS-96.
RX   PubMed=7358733;
RA   Shapiro R., McManus M.J., Zalut C., Bunn H.F.;
RT   "Sites of nonenzymatic glycosylation of human hemoglobin A.";
RL   J. Biol. Chem. 255:3120-3127(1980).
RN   [22]
RP   INTERACTION WITH HAPTOGLOBIN.
RX   MEDLINE=86242088; PubMed=3718478;
RA   Yoshioka N., Atassi M.Z.;
RT   "Haemoglobin binding with haptoglobin. Localization of the
RT   haptoglobin-binding sites on the beta-chain of human haemoglobin by
RT   synthetic overlapping peptides encompassing the entire chain.";
RL   Biochem. J. 234:453-456(1986).
RN   [23]
RP   OXIDATION AT LEU-142.
RX   PubMed=1520632;
RA   Brennan S.O., Shaw J., Allen J., George P.M.;
RT   "Beta 141 Leu is not deleted in the unstable haemoglobin Atlanta-
RT   Coventry but is replaced by a novel amino acid of mass 129 daltons.";
RL   Br. J. Haematol. 81:99-103(1992).
RN   [24]
RP   S-NITROSYLATION AT CYS-94.
RX   PubMed=8637569; DOI=10.1038/380221a0;
RA   Jia L., Bonaventura C., Bonaventura J., Stamler J.S.;
RT   "S-nitrosohaemoglobin: a dynamic activity of blood involved in
RT   vascular control.";
RL   Nature 380:221-226(1996).
RN   [25]
RP   S-NITROSYLATION AT CYS-94.
RX   MEDLINE=99060083; PubMed=9843411; DOI=10.1021/bi9816711;
RA   Chan N.L., Rogers P.H., Arnone A.;
RT   "Crystal structure of the S-nitroso form of liganded human
RT   hemoglobin.";
RL   Biochemistry 37:16459-16464(1998).
RN   [26]
RP   NITRIC OXIDE-BINDING.
RX   MEDLINE=20056222; PubMed=10588683; DOI=10.1073/pnas.96.25.14206;
RA   Durner J., Gow A.J., Stamler J.S., Glazebrook J.;
RT   "Ancient origins of nitric oxide signaling in biological systems.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:14206-14207(1999).
RN   [27]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-145, AND MASS SPECTROMETRY.
RC   TISSUE=Epithelium;
RX   PubMed=16916647; DOI=10.1016/j.molcel.2006.06.026;
RA   Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,
RA   Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.;
RT   "Substrate and functional diversity of lysine acetylation revealed by
RT   a proteomics survey.";
RL   Mol. Cell 23:607-618(2006).
RN   [28]
RP   SYNTHESIS OF 33-42, AND FUNCTION.
RX   PubMed=16904236; DOI=10.1016/j.peptides.2006.06.009;
RA   Ianzer D., Konno K., Xavier C.H., Stoecklin R., Santos R.A.S.,
RA   de Camargo A.C.M., Pimenta D.C.;
RT   "Hemorphin and hemorphin-like peptides isolated from dog pancreas and
RT   sheep brain are able to potentiate bradykinin activity in vivo.";
RL   Peptides 27:2957-2966(2006).
RN   [29]
RP   ELECTRON MICROSCOPY OF SICKLE-CELL HEMOGLOBIN FIBERS.
RX   PubMed=4123689;
RA   Finch J.T., Perutz M.F., Bertles J.F., Doebler J.;
RT   "Structure of sickled erythrocytes and of sickle-cell hemoglobin
RT   fibers.";
RL   Proc. Natl. Acad. Sci. U.S.A. 70:718-722(1973).
RN   [30]
RP   X-RAY CRYSTALLOGRAPHY (5 ANGSTROMS) OF MUTANT VAL-7.
RX   PubMed=1195378; DOI=10.1016/S0022-2836(75)80108-2;
RA   Wishner B.C., Ward K.B., Lattman E.E., Love W.E.;
RT   "Crystal structure of sickle-cell deoxyhemoglobin at 5 A resolution.";
RL   J. Mol. Biol. 98:179-194(1975).
RN   [31]
RP   X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF DEOXYHEMOGLOBIN.
RX   MEDLINE=76027820; PubMed=1177322; DOI=10.1016/S0022-2836(75)80037-4;
RA   Fermi G.;
RT   "Three-dimensional fourier synthesis of human deoxyhaemoglobin at 2.5-
RT   A resolution: refinement of the atomic model.";
RL   J. Mol. Biol. 97:237-256(1975).
RN   [32]
RP   X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF CARBONMONOXY HEMOGLOBIN.
RX   PubMed=7373648; DOI=10.1016/0022-2836(80)90308-3;
RA   Baldwin J.M.;
RT   "The structure of human carbonmonoxy haemoglobin at 2.7-A
RT   resolution.";
RL   J. Mol. Biol. 136:103-128(1980).
RN   [33]
RP   X-RAY CRYSTALLOGRAPHY (1.74 ANGSTROMS) OF DEOXYHEMOGLOBIN.
RX   PubMed=6726807; DOI=10.1016/0022-2836(84)90472-8;
RA   Fermi G., Perutz M.F., Shaanan B., Fourme R.;
RT   "The crystal structure of human deoxyhaemoglobin at 1.74 A
RT   resolution.";
RL   J. Mol. Biol. 175:159-174(1984).
RN   [34]
RP   X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF VARIANT ROTHSCHILD ARG-38.
RX   MEDLINE=92232710; PubMed=1567857; DOI=10.1021/bi00131a030;
RA   Kavanaugh J.S., Rogers P.H., Case D.A., Arnone A.;
RT   "High-resolution X-ray study of deoxyhemoglobin Rothschild 37 beta
RT   Trp-->Arg: a mutation that creates an intersubunit chloride-binding
RT   site.";
RL   Biochemistry 31:4111-4121(1992).
RN   [35]
RP   X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF MUTANT ARG-75.
RX   PubMed=1507231; DOI=10.1016/0022-2836(92)90638-Z;
RA   Fermi G., Perutz M.F., Williamson D., Stein P., Shih D.T.;
RT   "Structure-function relationships in the low-affinity mutant
RT   haemoglobin Aalborg (Gly74 (E18)beta-->Arg).";
RL   J. Mol. Biol. 226:883-888(1992).
RN   [36]
RP   X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS), AND BISPHOSPHOGLYCERATE
RP   BINDING.
RX   PubMed=8377203; DOI=10.1006/jmbi.1993.1505;
RA   Richard V., Dodson G.G., Mauguen Y.;
RT   "Human deoxyhaemoglobin-2,3-diphosphoglycerate complex low-salt
RT   structure at 2.5 A resolution.";
RL   J. Mol. Biol. 233:270-274(1993).
RN   [37]
RP   X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
RX   PubMed=8642597; DOI=10.1006/jmbi.1996.0124;
RA   Paoli M., Liddington R., Tame J., Wilkinson A., Dodson G.;
RT   "Crystal structure of T state haemoglobin with oxygen bound at all
RT   four haems.";
RL   J. Mol. Biol. 256:775-792(1996).
RN   [38]
RP   X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF MUTANTS ALA-38; GLU-38;
RP   GLY-38 AND TYR-38.
RX   PubMed=9521756; DOI=10.1021/bi9708702;
RA   Kavanaugh J.S., Weydert J.A., Rogers P.H., Arnone A.;
RT   "High-resolution crystal structures of human hemoglobin with mutations
RT   at tryptophan 37beta: structural basis for a high-affinity T-state.";
RL   Biochemistry 37:4358-4373(1998).
RN   [39]
RP   X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF MUTANT TRP-7.
RX   PubMed=9830011; DOI=10.1074/jbc.273.49.32690;
RA   Harrington D.J., Adachi K., Royer W.E. Jr.;
RT   "Crystal structure of deoxy-human hemoglobin beta6 Glu-->Trp.
RT   Implications for the structure and formation of the sickle cell
RT   fiber.";
RL   J. Biol. Chem. 273:32690-32696(1998).
RN   [40]
RP   X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF MUTANT LYS-7.
RX   PubMed=12454462; DOI=10.1107/S0907444902016426;
RA   Dewan J.C., Feeling-Taylor A., Puius Y.A., Patskovska L.,
RA   Patskovsky Y., Nagel R.L., Almo S.C., Hirsch R.E.;
RT   "Structure of mutant human carbonmonoxyhemoglobin C (betaE6K) at 2.0 A
RT   resolution.";
RL   Acta Crystallogr. D 58:2038-2042(2002).
RN   [41]
RP   VARIANT ALABAMA LYS-40.
RX   MEDLINE=75109326; PubMed=1115799;
RA   Brimhall B., Jones R.T., Schneider R.G., Hosty T.S., Tomlin G.,
RA   Atkins R.;
RT   "Two new hemoglobins. Hemoglobin Alabama (beta39(C5)Gln leads to Lys)
RT   and hemoglobin Montgomery (alpha 48(CD 6) Leu leads to Arg).";
RL   Biochim. Biophys. Acta 379:28-32(1975).
RN   [42]
RP   INVOLVEMENT IN HEINZ BODY ANEMIAS, AND VARIANT ST LOUIS GLN-29.
RX   PubMed=186485;
RA   Thillet J., Cohen-Solal M., Seligmann M., Rosa J.;
RT   "Functional and physicochemical studies of hemoglobin St. Louis beta
RT   28 (B10) Leu replaced by Gln: a variant with ferric beta heme iron.";
RL   J. Clin. Invest. 58:1098-1106(1976).
RN   [43]
RP   INVOLVEMENT IN DOMINANT BETA-THALASSEMIA INCLUSION BODY TYPE.
RX   PubMed=1971109;
RA   Thein S.L., Hesketh C., Taylor P., Temperley I.J., Hutchinson R.M.,
RA   Old J.M., Wood W.G., Clegg J.B., Weatherall D.J.;
RT   "Molecular basis for dominantly inherited inclusion body beta-
RT   thalassemia.";
RL   Proc. Natl. Acad. Sci. U.S.A. 87:3924-3928(1990).
RN   [44]
RP   VARIANT ALESHA MET-68.
RX   MEDLINE=93322192; PubMed=8330974;
RA   Molchanova T.P., Postnikov Y.V., Pobedimskaya D.D., Smetanina N.S.,
RA   Moschan A.A., Kazanetz E.G., Tokarev Y.N., Huisman T.H.J.;
RT   "Hb Alesha or alpha 2 beta (2)67(E11)Val-->Met: a new unstable
RT   hemoglobin variant identified through sequencing of amplified DNA.";
RL   Hemoglobin 17:217-225(1993).
RN   [45]
RP   VARIANT J-ALTGELDS GARDENS ASP-93.
RX   MEDLINE=79067354; PubMed=721609;
RA   Adams J.G. III, Przywara K.P., Heller P., Shamsuddin M.;
RT   "Hemoglobin J Altgeld Gardens. A hemoglobin variant with a
RT   substitution of the proximal histidine of the beta-chain.";
RL   Hemoglobin 2:403-415(1978).
RN   [46]
RP   VARIANT ANKARA ASP-11.
RX   MEDLINE=74297498; PubMed=4850241; DOI=10.1016/0014-5793(74)80766-0;
RA   Arcasoy A., Casey R., Lehmann H., Cavdar A.O., Berki A.;
RT   "A new haemoglobin J from Turkey -- Hb Ankara (beta10 (A7) Ala-Asp).";
RL   FEBS Lett. 42:121-123(1974).
RN   [47]
RP   VARIANTS J-ANTAKYA MET-66 AND COMPLUTENSE GLU-128.
RX   MEDLINE=86216227; PubMed=3707969; DOI=10.1016/0167-4838(86)90178-0;
RA   Huisman T.H.J., Wilson J.B., Kutlar A., Yang K.-G., Chen S.-S.,
RA   Webber B.B., Altay C., Martinez A.V.;
RT   "Hb J-Antakya or alpha 2 beta (2)65(E9)Lys-->Met in a Turkish family
RT   and Hb complutense or alpha 2 beta (2)127(H5)Gln-->Glu in a Spanish
RT   family; correction of a previously published identification.";
RL   Biochim. Biophys. Acta 871:229-231(1986).
RN   [48]
RP   VARIANT J-AUCKLAND ASP-26.
RX   MEDLINE=88006903; PubMed=3654265;
RA   Williamson D., Wells R.M.G., Anderson R., Matthews J.;
RT   "A new unstable and low oxygen affinity hemoglobin variant: Hb J-
RT   Auckland [beta 25(B7)Gly-->Asp].";
RL   Hemoglobin 11:221-230(1987).
RN   [49]
RP   VARIANT AURORA TYR-140.
RX   MEDLINE=96352910; PubMed=8718692;
RA   Lafferty J., Ali M., Matthew K., Eng B., Patterson M., Waye J.S.;
RT   "Identification of a new high oxygen affinity hemoglobin variant: Hb
RT   Aurora [beta 139(H17) Asn-->Tyr].";
RL   Hemoglobin 19:335-341(1995).
RN   [50]
RP   VARIANT BREST LYS-128.
RX   MEDLINE=88256755; PubMed=3384710;
RA   Baudin-Chich V., Wajcman H., Gombaud-Saintonge G., Arous N., Riou J.,
RA   Briere J., Galacteros F.;
RT   "Hemoglobin Brest [beta 127 (H5)Gln-->Lys] a new unstable human
RT   hemoglobin variant located at the alpha 1 beta 1 interface with
RT   specific electrophoretic behavior.";
RL   Hemoglobin 12:179-188(1988).
RN   [51]
RP   VARIANT BRISBANE HIS-69.
RX   MEDLINE=81239159; PubMed=6166590;
RA   Brennan S.O., Wells R.M., Smith H., Carrell R.W.;
RT   "Hemoglobin Brisbane: beta68 Leu replaced by His. A new high oxygen
RT   affinity variant.";
RL   Hemoglobin 5:325-335(1981).
RN   [52]
RP   VARIANT BUNBURY ASN-95.
RX   MEDLINE=84031649; PubMed=6629823;
RA   Como P.F., Kennett D., Wilkinson T., Kronenberg H.;
RT   "A new hemoglobin with high oxygen affinity -- hemoglobin Bunbury:
RT   alpha 2 beta 2 [94 (FG1) Asp replaced by Asn].";
RL   Hemoglobin 7:413-421(1983).
RN   [53]
RP   VARIANT J-CAIRO GLN-66.
RX   MEDLINE=76114933; PubMed=1247583;
RA   Garel M.-C., Hassan W., Coquelet M.T., Goossens M., Rosa J., Arous N.;
RT   "Hemoglobin J Cairo: beta 65 (E9) Lys leads to Gln, A new hemoglobin
RT   variant discovered in an Egyptian family.";
RL   Biochim. Biophys. Acta 420:97-104(1976).
RN   [54]
RP   VARIANT CAMPERDOWN SER-105.
RX   MEDLINE=75184109; PubMed=1138922;
RA   Wilkinson T., Chua C.G., Carrell R.W., Robin H., Exner T., Lee K.M.,
RA   Kronenberg H.;
RT   "A new haemoglobin variant, haemoglobin Camperdown (beta 104 (G6)
RT   arginine->serine).";
RL   Biochim. Biophys. Acta 393:195-200(1975).
RN   [55]
RP   VARIANT CARIBBEAN ARG-92.
RX   MEDLINE=77048866; PubMed=992050; DOI=10.1016/0014-5793(76)80662-X;
RA   Ahern E., Ahern V., Hilton T., Serjeant G.R., Serjeant B.E.,
RA   Seakins M., Lang A., Middleton A., Lehmann H.;
RT   "Haemoglobin caribbean beta91 (F7) Leu replaced by Arg: a mildly
RT   haemoglobin with a low oxygen affinity.";
RL   FEBS Lett. 69:99-102(1976).
RN   [56]
RP   VARIANT CITY OF HOPE SER-70.
RX   MEDLINE=85006311; PubMed=6434492;
RA   Rahbar S., Asmerom Y., Blume K.G.;
RT   "A silent hemoglobin variant detected by HPLC: hemoglobin City of Hope
RT   beta 69 (E13) Gly-->Ser.";
RL   Hemoglobin 8:333-342(1984).
RN   [57]
RP   VARIANT COIMBRA GLU-100.
RX   MEDLINE=92267852; PubMed=1814856;
RA   Tamagnini G.P., Ribeiro M.L., Valente V., Ramachandran M.,
RA   Wilson J.B., Baysal E., Gu L.H., Huisman T.H.J.;
RT   "Hb Coimbra or alpha 2 beta (2)99(G1)Asp-->Glu, a newly discovered
RT   high oxygen affinity variant.";
RL   Hemoglobin 15:487-496(1991).
RN   [58]
RP   VARIANT COSTA RICA ARG-78.
RX   MEDLINE=96235282; PubMed=8641705; DOI=10.1007/s004390050145;
RA   Romero W.E.R., Castillo M., Chaves M.A., Saenz G.F., Gu L.-H.,
RA   Wilson J.B., Baysal E., Smetanina N.S., Leonova J.Y., Huisman T.H.J.;
RT   "Hb Costa Rica or alpha 2 beta 2 77(EF1)His-->Arg: the first example
RT   of a somatic cell mutation in a globin gene.";
RL   Hum. Genet. 97:829-833(1996).
RN   [59]
RP   VARIANT DEBROUSSE PRO-97.
RX   MEDLINE=96180033; PubMed=8602627;
RA   Lacan P., Kister J., Francina A., Souillet G., Galacteros F.,
RA   Delaunay J., Wajcman H.;
RT   "Hemoglobin Debrousse (beta 96[FG3]Leu-->Pro): a new unstable
RT   hemoglobin with twofold increased oxygen affinity.";
RL   Am. J. Hematol. 51:276-281(1996).
RN   [60]
RP   VARIANT DHONBURI GLY-127.
RX   MEDLINE=90379198; PubMed=2399911;
RA   Bardakdjian-Michau J., Fucharoen S., Delanoe-Garin J., Kister J.,
RA   Lacombe C., Winichagoon P., Blouquit Y., Riou J., Wasi P.,
RA   Galacteros F.;
RT   "Hemoglobin Dhonburi alpha 2 beta 2 126 (H4) Val-->Gly: a new unstable
RT   beta variant producing a beta-thalassemia intermedia phenotype in
RT   association with beta zero-thalassemia.";
RL   Am. J. Hematol. 35:96-99(1990).
RN   [61]
RP   VARIANTS NEWCASTLE PRO-93 AND CAMPERDOWN SER-105, AND DESCRIPTION OF
RP   VARIANT DUINO.
RX   MEDLINE=92380658; PubMed=1511986; DOI=10.1007/BF00221961;
RA   Wajcman H., Blouquit Y., Vasseur C., le Querrec A., Laniece M.,
RA   Melevendi C., Rasore A., Galacteros F.;
RT   "Two new human hemoglobin variants caused by unusual mutational
RT   events: Hb Zaire contains a five residue repetition within the alpha-
RT   chain and Hb Duino has two residues substituted in the beta-chain.";
RL   Hum. Genet. 89:676-680(1992).
RN   [62]
RP   VARIANT DURHAM-N.C. PRO-115.
RX   MEDLINE=93244842; PubMed=1301199;
RA   Murru S., Poddie D., Sciarratta G.V., Agosti S., Baffico M.,
RA   Melevendi C., Pirastu M., Cao A.;
RT   "A novel beta-globin structural mutant, Hb Brescia (beta 114 Leu-Pro),
RT   causing a severe beta-thalassemia intermedia phenotype.";
RL   Hum. Mutat. 1:124-128(1992).
RN   [63]
RP   VARIANT DURHAM-N.C. PRO-115.
RX   MEDLINE=94154273; PubMed=8111050;
RA   de Castro C.M., Devlin B., Fleenor D.E., Lee M.E., Kaufman R.E.;
RT   "A novel beta-globin mutation, beta Durham-NC [beta 114 Leu-->Pro],
RT   produces a dominant thalassemia-like phenotype.";
RL   Blood 83:1109-1116(1994).
RN   [64]
RP   VARIANT J-EUROPA ASP-63.
RX   MEDLINE=96407264; PubMed=8811317;
RA   Kiger L., Kister J., Groff P., Kalmes G., Prome D., Galacteros F.,
RA   Wajcman H.;
RT   "Hb J-Europa [beta 62(E6)Ala-->Asp]: normal oxygen binding properties
RT   in a new variant involving a residue located distal to the heme.";
RL   Hemoglobin 20:135-140(1996).
RN   [65]
RP   VARIANT GEELONG ASP-140.
RX   MEDLINE=92010939; PubMed=1917539;
RA   Como P.F., Hocking D.R., Swinton G.W., Trent R.J., Holland R.A.B.,
RA   Tibben E.A., Wilkinson T., Kronenberg H.;
RT   "Hb Geelong [beta 139(H17)Asn-->Asp].";
RL   Hemoglobin 15:85-95(1991).
RN   [66]
RP   VARIANT GRANGE-BLANCHE VAL-28.
RX   MEDLINE=88030044; PubMed=3666141; DOI=10.1016/0014-5793(87)80509-4;
RA   Baklouti F., Giraud Y., Francina A., Richard G., Perier C.,
RA   Geyssant A., Jaubert J., Brizard C., Delaunay J.;
RT   "Hemoglobin Grange-Blanche [beta 27(B9) Ala-->Val], a new variant with
RT   normal expression and increased affinity for oxygen.";
RL   FEBS Lett. 223:59-62(1987).
RN   [67]
RP   VARIANT GRAZ LEU-3.
RX   MEDLINE=93138927; PubMed=1487420;
RA   Liu J.S., Molchanova T.P., Gu L.H., Wilson J.B., Hopmeier P.,
RA   Schnedl W., Balaun E., Krejs G.J., Huisman T.H.J.;
RT   "Hb Graz or alpha 2 beta 2(2)(NA2)His-->Leu; a new beta chain variant
RT   observed in four families from southern Austria.";
RL   Hemoglobin 16:493-501(1992).
RN   [68]
RP   VARIANT HELSINKI MET-83.
RX   MEDLINE=77062201; PubMed=826083;
RA   Ikkala E., Koskela J., Pikkarainen P., Rahiala E.-L., El-Hazmi M.A.F.,
RA   Nagai K., Lang A., Lehmann H.;
RT   "Hb Helsinki: a variant with a high oxygen affinity and a substitution
RT   at a 2,3-DPG binding site (beta82[EF6] Lys replaced by Met).";
RL   Acta Haematol. 56:257-275(1976).
RN   [69]
RP   VARIANT HIMEJI ASP-141.
RX   MEDLINE=86167527; PubMed=3754244;
RA   Ohba Y., Miyaji T., Murakami M., Kadowaki S., Fujita T., Oimomi M.,
RA   Hatanaka H., Ishikawa K., Baba S., Hitaka K., Imai K.;
RT   "Hb Himeji or beta 140 (H18) Ala-->Asp. A slightly unstable hemoglobin
RT   with increased beta N-terminal glycation.";
RL   Hemoglobin 10:109-126(1986).
RN   [70]
RP   VARIANT HINSDALE LYS-140.
RX   MEDLINE=90093866; PubMed=2513289;
RA   Moo-Penn W.F., Johnson M.H., Jue D.L., Lonser R.;
RT   "Hb Hinsdale [beta 139 (H17)Asn-->Lys]: a variant in the central
RT   cavity showing reduced affinity for oxygen and 2,3-
RT   diphosphoglycerate.";
RL   Hemoglobin 13:455-464(1989).
RN   [71]
RP   VARIANT HINWIL ASN-39.
RX   MEDLINE=96351651; PubMed=8745430;
RA   Frischknecht H., Ventruto M., Hess D., Hunziker P., Rosatelli M.C.,
RA   Cao A., Breitenstein U., Fehr J., Tuchschmid P.;
RT   "HB Hinwil or beta 38(C4)Thr-->Asn: a new beta chain variant detected
RT   in a Swiss family.";
RL   Hemoglobin 20:31-40(1996).
RN   [72]
RP   VARIANT HOWICK GLY-38.
RX   MEDLINE=94193408; PubMed=8144352;
RA   Owen M.C., Ockelford P.A., Wells R.M.G.;
RT   "Hb Howick [beta 37(C3)Trp-->Gly]: a new high oxygen affinity variant
RT   of the alpha 1 beta 2 contact.";
RL   Hemoglobin 17:513-521(1993).
RN   [73]
RP   VARIANT INDIANAPOLIS ARG-113.
RX   MEDLINE=79151109; PubMed=429365;
RA   Adams J.G. III, Steinberg M.H., Boxer L.A., Baehner R.L., Forget B.G.,
RA   Tsistrakis G.A.;
RT   "The structure of hemoglobin Indianapolis [beta112(G14) arginine]. An
RT   unstable variant detectable only by isotopic labeling.";
RL   J. Biol. Chem. 254:3479-3482(1979).
RN   [74]
RP   VARIANT ISEHARA ASN-93.
RX   MEDLINE=92155974; PubMed=1787097;
RA   Harano T., Harano K., Kushida Y., Ueda S., Yoshii A., Nishinarita M.;
RT   "Hb Isehara (or Hb Redondo) [beta 92 (F8) His-->Asn]: an unstable
RT   variant with a proximal histidine substitution at the heme contact.";
RL   Hemoglobin 15:279-290(1991).
RN   [75]
RP   VARIANT ISTAMBUL GLN-93.
RX   MEDLINE=73054825; PubMed=4639022;
RA   Aksoy M., Erdem S., Efremov G.D., Wilson J.B., Huisman T.H.J.,
RA   Schroeder W.A., Shelton J.R., Shelton J.B., Ulitin O.N., Muftuoglu A.;
RT   "Hemoglobin Istanbul: substitution of glutamine for histidine in a
RT   proximal histidine (F8(92)).";
RL   J. Clin. Invest. 51:2380-2387(1972).
RN   [76]
RP   VARIANT JACKSONVILLE ASP-55.
RX   MEDLINE=91331861; PubMed=2101840;
RA   Gaudry C.L. Jr., Pitel P.A., Jue D.L., Hine T.K., Johnson M.H.,
RA   Moo-Penn W.F.;
RT   "Hb Jacksonville [alpha 2 beta 2(54)(D5)Val-->Asp]: a new unstable
RT   variant found in a patient with hemolytic anemia.";
RL   Hemoglobin 14:653-659(1990).
RN   [77]
RP   VARIANT JIANGHUA ILE-121.
RX   MEDLINE=84007581; PubMed=6618888;
RA   Lu Y.Q., Fan J.L., Liu J.F., Hu H.L., Peng X.H., Huang C.-H.,
RA   Huang P.Y., Chen S.S., Jai P.C., Yang K.G.;
RT   "Hemoglobin Jianghua [beta 120(GH3) Lys leads to Ile]: a new fast-
RT   moving variant found in China.";
RL   Hemoglobin 7:321-326(1983).
RN   [78]
RP   VARIANT KARLSKOGA HIS-22.
RX   MEDLINE=93322190; PubMed=8330972;
RA   Landin B.;
RT   "Hb Karlskoga or alpha 2 beta (2)21(B3) Asp-->His: a new slow-moving
RT   variant found in Sweden.";
RL   Hemoglobin 17:201-208(1993).
RN   [79]
RP   VARIANT KNOSSOS SER-28.
RX   MEDLINE=83079719; PubMed=7173395; DOI=10.1016/0014-5793(82)81052-1;
RA   Arous N., Galacteros F., Fessas P., Loukopoulos D., Blouquit Y.,
RA   Komis G., Sellaye M., Boussiou M., Rosa J.;
RT   "Structural study of hemoglobin Knossos, beta 27 (B9) Ala leads to
RT   Ser. A new abnormal hemoglobin present as a silent beta-thalassemia.";
RL   FEBS Lett. 147:247-250(1982).
RN   [80]
RP   VARIANT KODAIRA GLN-147.
RX   MEDLINE=92340295; PubMed=1634367;
RA   Harano T., Harano K., Kushida Y., Imai K., Nishinakamura R.,
RA   Matsunaga T.;
RT   "Hb Kodaira [beta 146(HC3)His-->Gln]: a new beta chain variant with an
RT   amino acid substitution at the C-terminus.";
RL   Hemoglobin 16:85-91(1992).
RN   [81]
RP   VARIANT KOFU ILE-85.
RX   MEDLINE=86303641; PubMed=3744871;
RA   Harano T., Harano K., Ueda S., Imai N., Kitazumi T.;
RT   "A new electrophoretically-silent hemoglobin variant: hemoglobin Kofu
RT   or alpha 2 beta 2 84 (EF8) Thr-->Ile.";
RL   Hemoglobin 10:417-420(1986).
RN   [82]
RP   VARIANT HRADEC KRALOVE ASP-116.
RX   MEDLINE=94042221; PubMed=7693620;
RA   Divoky V., Svobodova M., Indrak K., Chrobak L., Molchanova T.P.,
RA   Huisman T.H.J.;
RT   "Hb Hradec Kralove (Hb HK) or alpha 2 beta 2 115(G17)Ala-->Asp, a
RT   severely unstable hemoglobin variant resulting in a dominant beta-
RT   thalassemia trait in a Czech family.";
RL   Hemoglobin 17:319-328(1993).
RN   [83]
RP   VARIANT LA DESIRADE VAL-130.
RX   MEDLINE=87165149; PubMed=3557994;
RA   Merault G., Keclard L., Garin J., Poyart C., Blouquit Y., Arous N.,
RA   Galacteros F., Feingold J., Rosa J.;
RT   "Hemoglobin La Desirade alpha A2 beta 2 129 (H7) Ala-->Val: a new
RT   unstable hemoglobin.";
RL   Hemoglobin 10:593-605(1986).
RN   [84]
RP   VARIANT LA ROCHE-SUR-YON HIS-82.
RX   MEDLINE=92172947; PubMed=1540659; DOI=10.1016/0925-4439(92)90052-O;
RA   Wajcman H., Kister J., Vasseur C., Blouquit Y., Trastour J.C.,
RA   Cottenceau D., Galacteros F.;
RT   "Structure of the EF corner favors deamidation of asparaginyl residues
RT   in hemoglobin: the example of Hb La Roche-sur-Yon [beta 81 (EF5)
RT   Leu-->His].";
RL   Biochim. Biophys. Acta 1138:127-132(1992).
RN   [85]
RP   VARIANT LAS PALMAS PHE-50.
RX   MEDLINE=88256753; PubMed=3384708;
RA   Malcorra-Azpiazu J.J., Balda-Aguirre M.I., Diaz-Chico J.C., Hu H.,
RA   Wilson J.B., Webber B.B., Kutlar F., Kutlar A., Huisman T.H.J.;
RT   "Hb Las Palmas or alpha 2 beta 2(49)(CD8)Ser-->Phe, a mildly unstable
RT   hemoglobin variant.";
RL   Hemoglobin 12:163-170(1988).
RN   [86]
RP   VARIANT LINKOPING THR-37.
RX   MEDLINE=88083482; PubMed=3691763;
RA   Berlin G., Wranne B., Jeppsson J.-O.;
RT   "Hb Linkoping (beta 36 Pro-->Thr): a new high oxygen affinity
RT   hemoglobin variant found in two families of Finnish origin.";
RL   Eur. J. Haematol. 39:452-456(1987).
RN   [87]
RP   VARIANT MAPUTO TYR-48.
RX   MEDLINE=84031650; PubMed=6629824;
RA   Marinucci M., Boissel J.P., Massa A., Wajcman H., Tentori L.,
RA   Labie D.;
RT   "Hemoglobin Maputo: a new beta-chain variant (alpha 2 beta 2 47 (CD6)
RT   Asp replaced by Tyr) in combination with hemoglobin S, identified by
RT   high performance liquid chromatography (HPLC).";
RL   Hemoglobin 7:423-433(1983).
RN   [88]
RP   VARIANT MATERA LYS-56.
RX   MEDLINE=90346586; PubMed=2384314;
RA   Sciarratta G.V., Ivaldi G.;
RT   "Hb Matera [beta 55(D6)Met-->Lys]: a new unstable hemoglobin variant
RT   in an Italian family.";
RL   Hemoglobin 14:79-85(1990).
RN   [89]
RP   VARIANT MIYASHIRO GLY-24.
RX   MEDLINE=82166873; PubMed=7338468;
RA   Nakatsuji T., Miwa S., Ohba Y., Hattori Y., Miyaji T., Miyata H.,
RA   Shinohara T., Hori T., Takayama J.;
RT   "Hemoglobin Miyashiro (beta 23[B5] val substituting for gly) an
RT   electrophoretically silent variant discovered by the isopropanol
RT   test.";
RL   Hemoglobin 5:653-666(1981).
RN   [90]
RP   VARIANT MIZUHO PRO-69.
RX   MEDLINE=77248961; PubMed=893142;
RA   Ohba Y., Miyaji T., Matsuoka M., Sugiyama K., Suzuki T., Sugiura T.;
RT   "Hemoglobin Mizuho or beta 68 (E 12) leucine leads to proline, a new
RT   unstable variant associated with severe hemolytic anemia.";
RL   Hemoglobin 1:467-477(1977).
RN   [91]
RP   VARIANT MUSCAT VAL-33.
RX   MEDLINE=92387956; PubMed=1517102;
RA   Ramachandran M., Gu L.H., Wilson J.B., Kitundu M.N., Adekile A.D.,
RA   Liu J.C., McKie K.M., Huisman T.H.J.;
RT   "A new variant, HB Muscat [alpha 2 beta (2)32(B14)Leu-->Val] observed
RT   in association with HB S in an Arabian family.";
RL   Hemoglobin 16:259-266(1992).
RN   [92]
RP   VARIANT N-TIMONE GLU-9.
RX   MEDLINE=90236754; PubMed=2634671;
RA   Lena-Russo D., Orsini A., Vovan L., Bardakdjian-Michau J., Lacombe C.,
RA   Blouquit Y., Craescu C.T., Galacteros F.;
RT   "Hb N-Timone [alpha 2 beta 2(8)(A5)Lys-->Glu]: a new fast-moving
RT   variant with normal stability and oxygen affinity.";
RL   Hemoglobin 13:743-747(1989).
RN   [93]
RP   VARIANT NAGOYA PRO-98.
RX   MEDLINE=85206960; PubMed=3838976;
RA   Ohba Y., Imanaka M., Matsuoka M., Hattori Y., Miyaji T., Funaki C.,
RA   Shibata K., Shimokata H., Kuzuya F., Miwa S.;
RT   "A new unstable, high oxygen affinity hemoglobin: Hb Nagoya or beta 97
RT   (FG4) His-->Pro.";
RL   Hemoglobin 9:11-24(1985).
RN   [94]
RP   VARIANT D-NEATH ALA-122.
RX   MEDLINE=93322197; PubMed=8330979;
RA   Welch S.G., Bateman C.;
RT   "Hb D-Neath or beta 121 (GH4) Glu-->Ala: a new member of the Hb D
RT   family.";
RL   Hemoglobin 17:255-259(1993).
RN   [95]
RP   VARIANT NORTH CHICAGO SER-37.
RX   MEDLINE=86139289; PubMed=3937824;
RA   Rahbar S., Louis J., Lee T., Asmerom Y.;
RT   "Hemoglobin North Chicago (beta 36 [C2] proline-->serine): a new high
RT   affinity hemoglobin.";
RL   Hemoglobin 9:559-576(1985).
RN   [96]
RP   VARIANT NORTH SHORE-CARACAS GLU-135.
RX   MEDLINE=77246803; PubMed=891976; DOI=10.1016/0014-5793(77)80453-5;
RA   Arends T., Lehmann H., Plowman D., Stathopoulou R.;
RT   "Haemoglobin North Shore-Caracas beta 134 (H12) valine replaced by
RT   glutamic acid.";
RL   FEBS Lett. 80:261-265(1977).
RN   [97]
RP   VARIANT OLOMOUC ASP-87.
RX   MEDLINE=87307470; PubMed=3623975;
RA   Indrak K., Wiedermann B.F., Batek F., Wilson J.B., Webber B.B.,
RA   Kutlar A., Huisman T.H.J.;
RT   "Hb Olomouc or alpha 2 beta 2(86)(F2)Ala-->Asp, a new high oxygen
RT   affinity variant.";
RL   Hemoglobin 11:151-155(1987).
RN   [98]
RP   VARIANT PALMERSTON NORTH PHE-24.
RX   MEDLINE=83135041; PubMed=7161106;
RA   Brennan S.O., Williamson D., Whisson M.E., Carrell R.W.;
RT   "Hemoglobin Palmerston North beta 23 (B5) Val replaced by Phe. A new
RT   variant identified in a patient with polycythemia.";
RL   Hemoglobin 6:569-575(1982).
RN   [99]
RP   VARIANT PIERRE-BENITE ASP-91.
RX   MEDLINE=88256754; PubMed=3384709;
RA   Baklouti F., Giraud Y., Francina A., Richard G., Favre-Gilly J.,
RA   Delaunay J.;
RT   "Hemoglobin Pierre-Benite [beta 90(F6)Glu-->Asp], a new high affinity
RT   variant found in a French family.";
RL   Hemoglobin 12:171-177(1988).
RN   [100]
RP   VARIANT PRESBYTERIAN LYS-109.
RX   MEDLINE=78215075; PubMed=668922; DOI=10.1016/0014-5793(78)80720-0;
RA   Moo-Penn W.F., Wolff J.A., Simon G., Vacek M., Jue D.L., Johnson M.H.;
RT   "Hemoglobin Presbyterian: beta108 (G10) asparagine leads to lysine, A
RT   hemoglobin variant with low oxygen affinity.";
RL   FEBS Lett. 92:53-56(1978).
RN   [101]
RP   VARIANT PUTTELANGE VAL-141.
RX   MEDLINE=96101899; PubMed=8522332; DOI=10.1007/BF00210304;
RA   Wajcman H., Girodon E., Prome D., North M.L., Plassa F., Duwig I.,
RA   Kister J., Bergerat J.P., Oberling F., Lampert E., Lonsdorfer J.,
RA   Goossens M., Galacteros F.;
RT   "Germline mosaicism for an alanine to valine substitution at residue
RT   beta 140 in hemoglobin Puttelange, a new variant with high oxygen
RT   affinity.";
RL   Hum. Genet. 96:711-716(1995).
RN   [102]
RP   VARIANT QUIN-HAI ARG-79.
RX   MEDLINE=84031648; PubMed=6629822;
RA   Jen P.C., Chen L.C., Chen P.F., Wong Y., Chen L.F., Guo Y.Y.,
RA   Chang F.Q., Chow Y.C., Chiu Y.;
RT   "Hemoglobin Quin-Hai, beta 78 (EF2) Leu replaced by Arg, a new
RT   abnormal hemoglobin found in Guangdong, China.";
RL   Hemoglobin 7:407-412(1983).
RN   [103]
RP   VARIANT RAMBAM ASP-70.
RX   MEDLINE=98432396; PubMed=9761252;
RA   Bisse E., Zorn N., Eigel A., Lizama M., Huamam-Guillen P., Marz W.,
RA   van Dorsselaer A., Wieland H.;
RT   "Hemoglobin Rambam (beta69[E13]Gly-->Asp), a pitfall in the assessment
RT   of diabetic control: characterization by electrospray mass
RT   spectrometry and HPLC.";
RL   Clin. Chem. 44:2172-2177(1998).
RN   [104]
RP   VARIANT RANDWICK GLY-16.
RX   MEDLINE=88256752; PubMed=3384707;
RA   Gilbert A.T., Fleming P.J., Sumner D.R., Hughes W.G., Ip F.,
RA   Kwan Y.L., Holland R.A.B.;
RT   "Hemoglobin Randwick or beta 15 (A12)Trp-->Gly: a new unstable beta-
RT   chain hemoglobin variant.";
RL   Hemoglobin 12:149-161(1988).
RN   [105]
RP   VARIANT RIO GRANDE THR-9.
RX   MEDLINE=83185445; PubMed=6857757;
RA   Moo-Penn W.F., Johnson M.H., McGuffey J.E., Jue D.L.,
RA   Therrell B.L. Jr.;
RT   "Hemoglobin Rio Grande [beta 8 (A5) Lys leads to Thr] a new variant
RT   found in a Mexican-American family.";
RL   Hemoglobin 7:91-95(1983).
RN   [106]
RP   VARIANT RUSH GLN-102.
RX   MEDLINE=74080282; PubMed=4129558;
RA   Adams J.G. III, Winter W.P., Tausk K., Heller P.;
RT   "Hemoglobin Rush (beta 101 (g3) glutamine): a new unstable hemoglobin
RT   causing mild hemolytic anemia.";
RL   Blood 43:261-269(1974).
RN   [107]
RP   VARIANT SAITAMA PRO-118.
RX   MEDLINE=83185440; PubMed=6687721;
RA   Ohba Y., Hasegawa Y., Amino H., Miwa S., Nakatsuji T., Hattori Y.,
RA   Miyaji T.;
RT   "Hemoglobin Saitama or beta 117 (G19) His leads to Pro, a new variant
RT   causing hemolytic disease.";
RL   Hemoglobin 7:47-56(1983).
RN   [108]
RP   VARIANT M-SASKATOON TYR-64.
RX   PubMed=13897827;
RA   Gerald P.S., Efron M.L.;
RT   "Chemical studies of several varieties of Hb M.";
RL   Proc. Natl. Acad. Sci. U.S.A. 47:1758-1767(1961).
RN   [109]
RP   VARIANT SHELBY/LESLIE/DEACONESS LYS-132.
RX   MEDLINE=85130256; PubMed=6526653;
RA   Moo-Penn W.F., Johnson M.H., McGuffey J.E., Jue D.L.;
RT   "Hemoglobin Shelby [beta 131(H9) Gln-->Lys] a correction to the
RT   structure of hemoglobin Deaconess and hemoglobin Leslie.";
RL   Hemoglobin 8:583-593(1984).
RN   [110]
RP   VARIANT J-SICILIA ASN-66.
RX   MEDLINE=74302182; PubMed=4852224; DOI=10.1016/0014-5793(74)80050-5;
RA   Ricco G., Pich P.G., Mazza U., Rossi G., Ajmar P., Arese P., Gallo E.;
RT   "Hb J Sicilia: beta 65 (E9) Lys-Asn, a beta homologue of Hb Zambia.";
RL   FEBS Lett. 39:200-204(1974).
RN   [111]
RP   VARIANT STANMORE ALA-112.
RX   MEDLINE=92010936; PubMed=1917537;
RA   Como P.F., Wylie B.R., Trent R.J., Bruce D., Volpato F., Wilkinson T.,
RA   Kronenberg H., Holland R.A.B., Tibben E.A.;
RT   "A new unstable and low oxygen affinity hemoglobin variant: Hb
RT   Stanmore [beta 111(G13)Val-->Ala].";
RL   Hemoglobin 15:53-65(1991).
RN   [112]
RP   VARIANT ST MANDE TYR-103.
RX   MEDLINE=81212764; PubMed=7238856; DOI=10.1016/0014-5793(81)81046-0;
RA   Arous N., Braconnier F., Thillet J., Blouquit Y., Galacteros F.,
RA   Chevrier M., Bordahandy C., Rosa J.;
RT   "Hemoglobin Saint Mande beta 102 (G4) asn replaced by tyr: a new low
RT   oxygen affinity variant.";
RL   FEBS Lett. 126:114-116(1981).
RN   [113]
RP   VARIANT WINDSOR ASP-12.
RX   MEDLINE=90093865; PubMed=2599880;
RA   Gilbert A.T., Fleming P.J., Sumner D.R., Hughes W.G., Holland R.A.B.,
RA   Tibben E.A.;
RT   "Hemoglobin Windsor or beta 11 (A8)Val-->Asp: a new unstable beta-
RT   chain hemoglobin variant producing a hemolytic anemia.";
RL   Hemoglobin 13:437-453(1989).
RN   [114]
RP   VARIANT YAHATA TYR-113.
RX   MEDLINE=92010926; PubMed=1917530;
RA   Harano T., Harano K., Kushida Y., Ueda S.;
RT   "A new abnormal variant, Hb Yahata or beta 112(G14)Cys-->Tyr, found in
RT   a Japanese: structural confirmation by DNA sequencing of the beta-
RT   globin gene.";
RL   Hemoglobin 15:109-113(1991).
RN   [115]
RP   VARIANT YOKOHAMA PRO-32.
RX   MEDLINE=82166874; PubMed=7338469;
RA   Nakatsuji T., Miwa S., Ohba Y., Hattori Y., Miyaji T., Hino S.,
RA   Matsumoto N.;
RT   "A new unstable hemoglobin, Hb Yokohama beta 31 (B13)Leu substituting
RT   for Pro, causing hemolytic anemia.";
RL   Hemoglobin 5:667-678(1981).
RN   [116]
RP   INVOLVEMENT IN HEINZ BODY ANEMIAS, AND VARIANT HAMMERSMITH SER-43.
RX   PubMed=6259091;
RA   Rahbar S., Feagler R.J., Beutler E.;
RT   "Hemoglobin Hammersmith (beta 42 (CD1) Phe replaced by Ser) associated
RT   with severe hemolytic anemia.";
RL   Hemoglobin 5:97-105(1981).
RN   [117]
RP   INVOLVEMENT IN HEINZ BODY ANEMIAS, AND VARIANTS BRUXELLES PHE-42 DEL
RP   AND PHE-43 DEL.
RX   PubMed=2599881;
RA   Blouquit Y., Bardakdjian J., Lena-Russo D., Arous N., Perrimond H.,
RA   Orsini A., Rosa J., Galacteros F.;
RT   "Hb Bruxelles: alpha 2A beta (2)41 or 42(C7 or CD1)Phe deleted.";
RL   Hemoglobin 13:465-474(1989).
RN   [118]
RP   VARIANT ZENGCHENG MET-115.
RX   MEDLINE=91177717; PubMed=2079435;
RA   Plaseska D., Wilson J.B., Gu L.H., Kutlar F., Huisman T.H.J.,
RA   Zeng Y.T., Shen M.;
RT   "Hb Zengcheng or alpha 2 beta(2)114(G16)Leu-->Met.";
RL   Hemoglobin 14:555-557(1990).
RN   [119]
RP   VARIANT NON-SPHEROCYTIC HAEMOLITIC ANEMIA GLY-68.
RX   PubMed=8280608;
RA   Fay K.C., Brennan S.O., Costello J.M., Potter H.C., Williamson D.A.,
RA   Trent R.J., Ockelford P.A., Boswell D.R.;
RT   "Haemoglobin Manukau beta 67[E11] Val-->Gly: transfusion-dependent
RT   haemolytic anaemia ameliorated by coexisting alpha thalassaemia.";
RL   Br. J. Haematol. 85:352-355(1993).
RN   [120]
RP   INVOLVEMENT IN HEINZ BODY ANEMIAS, AND VARIANT BRISTOL ASP-68.
RX   PubMed=8704193;
RA   Rees D.C., Rochette J., Schofield C., Green B., Morris M.,
RA   Parker N.E., Sasaki H., Tanaka A., Ohba Y., Clegg J.B.;
RT   "A novel silent posttranslational mechanism converts methionine to
RT   aspartate in hemoglobin Bristol (beta 67[E11] Val-Met->Asp).";
RL   Blood 88:341-348(1996).
RN   [121]
RP   VARIANT IRAQ-HALABJA VAL-11.
RX   PubMed=10398311;
RX   DOI=10.1002/(SICI)1096-8652(199907)61:3<187::AID-AJH5>3.0.CO;2-7;
RA   Deutsch S., Darbellay R., Offord R.E., Frutiger A., Kister J.,
RA   Wajcman H., Beris P.;
RT   "Hb Iraq-Halabja beta10 (A7) Ala-->Val (GCC-->GTC): a new beta-chain
RT   silent variant in a family with multiple Hb disorders.";
RL   Am. J. Hematol. 61:187-193(1999).
RN   [122]
RP   VARIANT VILLEJUIF ILE-124.
RX   PubMed=11300351; DOI=10.1081/HEM-100103071;
RA   Carbone V., Salzano A.M., Pagano L., Buffardi S., De Rosa C.,
RA   Pucci P.;
RT   "Identification of Hb Villejuif [beta123(H1)Thr-->Ile] in Southern
RT   Italy.";
RL   Hemoglobin 25:67-78(2001).
RN   [123]
RP   VARIANT TSUKUMI TYR-118.
RX   PubMed=11300344; DOI=10.1081/HEM-100103076;
RA   North M.L., Duwig I., Riou J., Prome D., Yapo A.P., Kister J.,
RA   Bardakdjian-Michau J., Cazenave J.-P., Wajcman H.;
RT   "Hb Tsukumi [beta117(G19)His-->Tyr] found in a Moroccan woman.";
RL   Hemoglobin 25:107-110(2001).
RN   [124]
RP   VARIANT CANTERBURY PHE-113.
RX   PubMed=11939514; DOI=10.1081/HEM-120002942;
RA   Brennan S.O., Potter H.C., Kubala L.M., Carnoutsos S.A.,
RA   Ferguson M.M.;
RT   "Hb Canterbury [beta112(G14)Cys-->Phe]: a new, mildly unstable
RT   variant.";
RL   Hemoglobin 26:67-69(2002).
RN   [125]
RP   VARIANT PYRGOS ASP-84, AND VARIANT E LYS-27.
RX   PubMed=12144064; DOI=10.1081/HEM-120005459;
RA   Sawangareetrakul P., Svasti S., Yodsowon B., Winichagoon P.,
RA   Srisomsap C., Svasti J., Fucharoen S.;
RT   "Double heterozygosity for Hb Pyrgos [beta83(EF7)Gly-->Asp] and Hb E
RT   [beta26(B8)Glu-->Lys] found in association with alpha-thalassemia.";
RL   Hemoglobin 26:191-196(2002).
RN   [126]
RP   VARIANT SANTANDER ASP-35.
RX   PubMed=12603091; DOI=10.1081/HEM-120016378;
RA   Villegas A., Ropero P., Nogales A., Gonzalez F.A., Mateo M., Mazo E.,
RA   Rodrigo E., Arias M.;
RT   "Hb Santander [beta34(B16)Val-->Asp (GTC-->GAC)]: a new unstable
RT   variant found as a de novo mutation in a Spanish patient.";
RL   Hemoglobin 27:31-35(2003).
RN   [127]
RP   VARIANT NANTES LEU-35, AND VARIANT VEXIN LEU-117.
RX   PubMed=12908805; DOI=10.1081/HEM-120023384;
RA   Wajcman H., Bardakdjian-Michau J., Riou J., Prehu C., Kister J.,
RA   Baudin-Creuza V., Prome D., Richelme-David S., Harousseau J.L.,
RA   Galacteros F.;
RT   "Two new hemoglobin variants with increased oxygen affinity: Hb Nantes
RT   [beta34(B16)Val-->Leu] and Hb Vexin [beta116(G18)His-->Leu].";
RL   Hemoglobin 27:191-199(2003).
RN   [128]
RP   VARIANT LYS-27.
RX   PubMed=15481886; DOI=10.1081/HEM-120040334;
RA   Flatz G., Sanguansermsri T., Sengchanh S., Horst D., Horst J.;
RT   "The 'hot-spot' of Hb E [beta26(B8)Glu-->Lys] in Southeast Asia: beta-
RT   globin anomalies in the Lao Theung population of southern Laos.";
RL   Hemoglobin 28:197-204(2004).
CC   -!- FUNCTION: Involved in oxygen transport from the lung to the
CC       various peripheral tissues.
CC   -!- FUNCTION: LVV-hemorphin-7 potentiates the activity of bradykinin,
CC       causing a decrease in blood pressure.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains in
CC       adult hemoglobin A (HbA).
CC   -!- INTERACTION:
CC       P69905:HBA1; NbExp=1; IntAct=EBI-715554, EBI-714680;
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- PTM: Glucose reacts non-enzymatically with the N-terminus of the
CC       beta chain to form a stable ketoamine linkage. This takes place
CC       slowly and continuously throughout the 120-day life span of the
CC       red blood cell. The rate of glycation is increased in patients
CC       with diabetes mellitus.
CC   -!- PTM: S-nitrosylated; a nitric oxide group is first bound to Fe(2+)
CC       and then transferred to Cys-94 to allow capture of O(2).
CC   -!- PTM: Acetylated on Lys-60, Lys-83 and Lys-145 upon aspirin
CC       exposure. PubMed:16916647 reports the identification of HBB
CC       acetylated on Lys-145 in the cytosolic fraction of HeLa cells.
CC       This may results from a contamination of the sample.
CC   -!- MASS SPECTROMETRY: Mass=1310; Method=FAB; Range=33-42;
CC       Source=PubMed:1575724;
CC   -!- DISEASE: Defects in HBB may be a cause of Heinz body anemias
CC       [MIM:140700]. This is a form of non-spherocytic hemolytic anemia
CC       of Dacie type 1. After splenectomy, which has little benefit,
CC       basophilic inclusions called Heinz bodies are demonstrable in the
CC       erythrocytes. Before splenectomy, diffuse or punctate basophilia
CC       may be evident. Most of these cases are probably instances of
CC       hemoglobinopathy. The hemoglobin demonstrates heat lability. Heinz
CC       bodies are observed also with the Ivemark syndrome (asplenia with
CC       cardiovascular anomalies) and with glutathione peroxidase
CC       deficiency.
CC   -!- DISEASE: Defects in HBB are the cause of beta-thalassemia
CC       [MIM:141900, 604131]. The thalassemias are the most common
CC       monogenic diseases and occur mostly in Mediterranean and Southeast
CC       Asian populations. The hallmark of beta-thalassemia is an
CC       imbalance in globin-chain production in the adult HbA molecule.
CC       Absence of beta chain causes beta(0)-thalassemia, while reduced
CC       amounts of detectable beta globin causes beta(+)-thalassemia. In
CC       the severe forms of beta-thalassemia, the excess alpha globin
CC       chains accumulate in the developing erythroid precursors in the
CC       marrow. Their deposition leads to a vast increase in erythroid
CC       apoptosis that in turn causes ineffective erythropoiesis and
CC       severe microcytic hypochromic anemia. Clinically, beta-thalassemia
CC       is divided into thalassemia major (transfusion dependent),
CC       thalassemia intermedia (of intermediate severity), and thalassemia
CC       minor (asymptomatic).
CC   -!- DISEASE: Defects in HBB are the cause of sickle cell anemia
CC       [MIM:603903]; also known as sickle cell disease. Sickle cell
CC       anemia is characterized by abnormally shaped red cells resulting
CC       in chronic anemia and periodic episodes of pain, serious
CC       infections and damage to vital organs. Normal red blood cells are
CC       round and flexible and flow easily through blood vessels, but in
CC       sickle cell anemia, the abnormal hemoglobin (called Hb S) causes
CC       red blood cells to become stiff. They are C-shaped and resembles a
CC       sickle. These stiffer red blood cells can led to microvascular
CC       occlusion thus cutting off the blood supply to nearby tissues.
CC   -!- DISEASE: Defects in HBB are the cause of dominant beta-thalassemia
CC       inclusion body type [MIM:603902]. This form of beta-thalassemia is
CC       transmitted in an autosomal dominant fashion and is characterized
CC       by anemia, enlargement of the spleen, and gross abnormalities of
CC       the erythrocytes and their precursors.
CC   -!- MISCELLANEOUS: One molecule of 2,3-bisphospoglycerate can bind to
CC       two beta chains per hemoglobin tetramer.
CC   -!- SIMILARITY: Belongs to the globin family.
CC   -!- WEB RESOURCE: Name=HbVar; Note=Human hemoglobin variants and
CC       thalassemias;
CC       URL="http://globin.bx.psu.edu/cgi-bin/hbvar/query_vars3?mode=directlink&gene=HBB";
CC   -!- WEB RESOURCE: Name=GeneReviews;
CC       URL="http://www.genetests.org/query?gene=HBB";
CC   -!- WEB RESOURCE: Name=SHMPD; Note=The Singapore human mutation and
CC       polymorphism database;
CC       URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=HBB";
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Hemoglobin entry;
CC       URL="http://en.wikipedia.org/wiki/Hemoglobin";
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DR   EMBL; M25079; AAA35597.1; -; mRNA.
DR   EMBL; V00499; CAA23758.1; -; Genomic_DNA.
DR   EMBL; DQ126270; AAZ39745.1; -; Genomic_DNA.
DR   EMBL; DQ126271; AAZ39746.1; -; Genomic_DNA.
DR   EMBL; DQ126272; AAZ39747.1; -; Genomic_DNA.
DR   EMBL; DQ126273; AAZ39748.1; -; Genomic_DNA.
DR   EMBL; DQ126274; AAZ39749.1; -; Genomic_DNA.
DR   EMBL; DQ126275; AAZ39750.1; -; Genomic_DNA.
DR   EMBL; DQ126276; AAZ39751.1; -; Genomic_DNA.
DR   EMBL; DQ126277; AAZ39752.1; -; Genomic_DNA.
DR   EMBL; DQ126278; AAZ39753.1; -; Genomic_DNA.
DR   EMBL; DQ126279; AAZ39754.1; -; Genomic_DNA.
DR   EMBL; DQ126280; AAZ39755.1; -; Genomic_DNA.
DR   EMBL; DQ126281; AAZ39756.1; -; Genomic_DNA.
DR   EMBL; DQ126282; AAZ39757.1; -; Genomic_DNA.
DR   EMBL; DQ126283; AAZ39758.1; -; Genomic_DNA.
DR   EMBL; DQ126284; AAZ39759.1; -; Genomic_DNA.
DR   EMBL; DQ126285; AAZ39760.1; -; Genomic_DNA.
DR   EMBL; DQ126286; AAZ39761.1; -; Genomic_DNA.
DR   EMBL; DQ126287; AAZ39762.1; -; Genomic_DNA.
DR   EMBL; DQ126288; AAZ39763.1; -; Genomic_DNA.
DR   EMBL; DQ126289; AAZ39764.1; -; Genomic_DNA.
DR   EMBL; DQ126290; AAZ39765.1; -; Genomic_DNA.
DR   EMBL; DQ126291; AAZ39766.1; -; Genomic_DNA.
DR   EMBL; DQ126292; AAZ39767.1; -; Genomic_DNA.
DR   EMBL; DQ126293; AAZ39768.1; -; Genomic_DNA.
DR   EMBL; DQ126294; AAZ39769.1; -; Genomic_DNA.
DR   EMBL; DQ126295; AAZ39770.1; -; Genomic_DNA.
DR   EMBL; DQ126296; AAZ39771.1; -; Genomic_DNA.
DR   EMBL; DQ126297; AAZ39772.1; -; Genomic_DNA.
DR   EMBL; DQ126298; AAZ39773.1; -; Genomic_DNA.
DR   EMBL; DQ126299; AAZ39774.1; -; Genomic_DNA.
DR   EMBL; DQ126300; AAZ39775.1; -; Genomic_DNA.
DR   EMBL; DQ126301; AAZ39776.1; -; Genomic_DNA.
DR   EMBL; DQ126302; AAZ39777.1; -; Genomic_DNA.
DR   EMBL; DQ126303; AAZ39778.1; -; Genomic_DNA.
DR   EMBL; DQ126304; AAZ39779.1; -; Genomic_DNA.
DR   EMBL; DQ126305; AAZ39780.1; -; Genomic_DNA.
DR   EMBL; DQ126306; AAZ39781.1; -; Genomic_DNA.
DR   EMBL; DQ126307; AAZ39782.1; -; Genomic_DNA.
DR   EMBL; DQ126308; AAZ39783.1; -; Genomic_DNA.
DR   EMBL; DQ126309; AAZ39784.1; -; Genomic_DNA.
DR   EMBL; DQ126310; AAZ39785.1; -; Genomic_DNA.
DR   EMBL; DQ126311; AAZ39786.1; -; Genomic_DNA.
DR   EMBL; DQ126312; AAZ39787.1; -; Genomic_DNA.
DR   EMBL; DQ126313; AAZ39788.1; -; Genomic_DNA.
DR   EMBL; DQ126314; AAZ39789.1; -; Genomic_DNA.
DR   EMBL; DQ126315; AAZ39790.1; -; Genomic_DNA.
DR   EMBL; DQ126316; AAZ39791.1; -; Genomic_DNA.
DR   EMBL; DQ126317; AAZ39792.1; -; Genomic_DNA.
DR   EMBL; DQ126318; AAZ39793.1; -; Genomic_DNA.
DR   EMBL; DQ126319; AAZ39794.1; -; Genomic_DNA.
DR   EMBL; DQ126320; AAZ39795.1; -; Genomic_DNA.
DR   EMBL; DQ126321; AAZ39796.1; -; Genomic_DNA.
DR   EMBL; DQ126322; AAZ39797.1; -; Genomic_DNA.
DR   EMBL; DQ126323; AAZ39798.1; -; Genomic_DNA.
DR   EMBL; DQ126324; AAZ39799.1; -; Genomic_DNA.
DR   EMBL; DQ126325; AAZ39800.1; -; Genomic_DNA.
DR   EMBL; AF007546; AAB62944.1; -; Genomic_DNA.
DR   EMBL; AF117710; AAD19696.1; -; mRNA.
DR   EMBL; AF181989; AAF00489.1; -; mRNA.
DR   EMBL; AF349114; AAK29639.1; -; mRNA.
DR   EMBL; AF527577; AAM92001.1; -; Genomic_DNA.
DR   EMBL; AY136510; AAN11320.1; -; mRNA.
DR   EMBL; AY163866; AAN84548.1; -; Genomic_DNA.
DR   EMBL; AY260740; AAP21062.1; -; Genomic_DNA.
DR   EMBL; CR536530; CAG38767.1; -; mRNA.
DR   EMBL; CR541913; CAG46711.1; -; mRNA.
DR   EMBL; BC007075; AAH07075.1; -; mRNA.
DR   EMBL; U01317; AAA16334.1; -; Genomic_DNA.
DR   EMBL; V00497; CAA23756.1; -; mRNA.
DR   EMBL; V00500; CAA23759.1; ALT_SEQ; mRNA.
DR   EMBL; L26462; AAA21100.1; -; Genomic_DNA.
DR   EMBL; L26463; AAA21101.1; -; Genomic_DNA.
DR   EMBL; L26464; AAA21102.1; -; Genomic_DNA.
DR   EMBL; L26465; AAA21103.1; -; Genomic_DNA.
DR   EMBL; L26466; AAA21104.1; -; Genomic_DNA.
DR   EMBL; L26467; AAA21105.1; -; Genomic_DNA.
DR   EMBL; L26468; AAA21106.1; -; Genomic_DNA.
DR   EMBL; L26469; AAA21107.1; -; Genomic_DNA.
DR   EMBL; L26470; AAA21108.1; -; Genomic_DNA.
DR   EMBL; L26471; AAA21109.1; -; Genomic_DNA.
DR   EMBL; L26472; AAA21110.1; -; Genomic_DNA.
DR   EMBL; L26473; AAA21111.1; -; Genomic_DNA.
DR   EMBL; L26474; AAA21112.1; -; Genomic_DNA.
DR   EMBL; L26475; AAA21113.1; -; Genomic_DNA.
DR   EMBL; L26476; AAA21114.1; -; Genomic_DNA.
DR   EMBL; L26477; AAA21115.1; -; Genomic_DNA.
DR   EMBL; L26478; AAA21116.1; -; Genomic_DNA.
DR   EMBL; L48213; AAA88063.1; -; Genomic_DNA.
DR   EMBL; L48214; AAA88061.1; -; Genomic_DNA.
DR   EMBL; L48215; AAA88059.1; -; Genomic_DNA.
DR   EMBL; L48216; AAA88065.1; -; Genomic_DNA.
DR   EMBL; L48217; AAA88067.1; -; Genomic_DNA.
DR   EMBL; M36640; AAA52634.1; -; Genomic_DNA.
DR   EMBL; M11428; AAA52633.1; -; mRNA.
DR   EMBL; M25113; AAA35966.1; -; mRNA.
DR   EMBL; L48932; AAA88054.1; -; Genomic_DNA.
DR   EMBL; A01592; CAA00182.1; -; Unassigned_DNA.
DR   PIR; A53136; HBHU.
DR   RefSeq; NP_000509.1; -.
DR   UniGene; Hs.523443; -.
DR   PDB; 1A00; X-ray; 2.00 A; B/D=3-147.
DR   PDB; 1A01; X-ray; 1.80 A; B/D=3-147.
DR   PDB; 1A0U; X-ray; 2.14 A; B/D=3-147.
DR   PDB; 1A0Z; X-ray; 2.00 A; B/D=3-147.
DR   PDB; 1A3N; X-ray; 1.80 A; B/D=1-147.
DR   PDB; 1A3O; X-ray; 1.80 A; B/D=1-147.
DR   PDB; 1ABW; X-ray; 2.00 A; B/D=3-147.
DR   PDB; 1ABY; X-ray; 2.60 A; B/D=3-147.
DR   PDB; 1AJ9; X-ray; 2.20 A; B=1-147.
DR   PDB; 1B86; X-ray; 2.50 A; B/D=1-147.
DR   PDB; 1BAB; X-ray; 1.50 A; B/D=1-147.
DR   PDB; 1BBB; X-ray; 1.70 A; B/D=1-147.
DR   PDB; 1BIJ; X-ray; 2.30 A; B/D=1-147.
DR   PDB; 1BUW; X-ray; 1.90 A; B/D=2-147.
DR   PDB; 1BZ0; X-ray; 1.50 A; B/D=1-147.
DR   PDB; 1BZ1; X-ray; 1.59 A; B/D=1-147.
DR   PDB; 1BZZ; X-ray; 1.59 A; B/D=1-147.
DR   PDB; 1C7B; X-ray; 1.80 A; B/D=3-147.
DR   PDB; 1C7C; X-ray; 1.80 A; B/D=3-147.
DR   PDB; 1C7D; X-ray; 1.80 A; B/D=3-147.
DR   PDB; 1CBL; X-ray; 1.80 A; A/B/C/D=1-147.
DR   PDB; 1CBM; X-ray; 1.74 A; A/B/C/D=1-147.
DR   PDB; 1CH4; X-ray; 2.50 A; A=2-129.
DR   PDB; 1CLS; X-ray; 1.90 A; B/D=1-147.
DR   PDB; 1CMY; X-ray; 3.00 A; B/D=1-147.
DR   PDB; 1COH; X-ray; 2.90 A; B/D=1-147.
DR   PDB; 1DKE; X-ray; 2.10 A; B/D=1-147.
DR   PDB; 1DXT; X-ray; 1.70 A; B/D=1-147.
DR   PDB; 1DXU; X-ray; 1.70 A; B/D=3-147.
DR   PDB; 1DXV; X-ray; 1.70 A; B/D=3-147.
DR   PDB; 1FN3; X-ray; 2.48 A; B/D=1-147.
DR   PDB; 1G9V; X-ray; 1.85 A; B/D=1-147.
DR   PDB; 1GBU; X-ray; 1.80 A; B/D=1-147.
DR   PDB; 1GBV; X-ray; 2.00 A; B/D=1-147.
DR   PDB; 1GLI; X-ray; 2.50 A; B/D=3-147.
DR   PDB; 1GZX; X-ray; 2.10 A; B/D=1-147.
DR   PDB; 1HAB; X-ray; 2.30 A; B/D=1-147.
DR   PDB; 1HAC; X-ray; 2.60 A; B/D=1-147.
DR   PDB; 1HBA; X-ray; 2.10 A; B/D=1-147.
DR   PDB; 1HBB; X-ray; 1.90 A; B/D=1-147.
DR   PDB; 1HBS; X-ray; 3.00 A; B/D/F/H=1-147.
DR   PDB; 1HCO; X-ray; 2.70 A; B=1-147.
DR   PDB; 1HDB; X-ray; 2.20 A; B/D=1-147.
DR   PDB; 1HGA; X-ray; 2.10 A; B/D=1-147.
DR   PDB; 1HGB; X-ray; 2.10 A; B/D=1-147.
DR   PDB; 1HGC; X-ray; 2.10 A; B/D=1-147.
DR   PDB; 1HHO; X-ray; 2.10 A; B=1-147.
DR   PDB; 1IRD; X-ray; 1.25 A; B=1-147.
DR   PDB; 1J3Y; X-ray; 1.55 A; B/D/F/H=1-147.
DR   PDB; 1J3Z; X-ray; 1.60 A; B/D/F/H=1-147.
DR   PDB; 1J40; X-ray; 1.45 A; B/D/F/H=1-147.
DR   PDB; 1J41; X-ray; 1.45 A; B/D/F/H=1-147.
DR   PDB; 1J7S; X-ray; 2.20 A; B/D=3-147.
DR   PDB; 1J7W; X-ray; 2.00 A; B/D=3-147.
DR   PDB; 1J7Y; X-ray; 1.70 A; B/D=3-147.
DR   PDB; 1JY7; X-ray; 3.20 A; B/D/Q/S/V/X=1-147.
DR   PDB; 1K0Y; X-ray; 1.87 A; B/D=1-147.
DR   PDB; 1K1K; X-ray; 2.00 A; B=1-147.
DR   PDB; 1KD2; X-ray; 1.87 A; B/D=1-147.
DR   PDB; 1LFL; X-ray; 2.70 A; B/D/Q/S=1-147.
DR   PDB; 1LFQ; X-ray; 2.60 A; B=1-147.
DR   PDB; 1LFT; X-ray; 2.60 A; B=1-147.
DR   PDB; 1LFV; X-ray; 2.80 A; B=1-147.
DR   PDB; 1LFY; X-ray; 3.30 A; B=1-147.
DR   PDB; 1LFZ; X-ray; 3.10 A; B=1-147.
DR   PDB; 1LJW; X-ray; 2.16 A; B=1-147.
DR   PDB; 1M9P; X-ray; 2.10 A; B/D=1-147.
DR   PDB; 1MKO; X-ray; 2.18 A; B/D=1-147.
DR   PDB; 1NEJ; X-ray; 2.10 A; B/D=1-147.
DR   PDB; 1NIH; X-ray; 2.60 A; B/D=1-147.
DR   PDB; 1NQP; X-ray; 1.73 A; B/D=1-147.
DR   PDB; 1O1I; X-ray; 2.30 A; B=1-147.
DR   PDB; 1O1J; X-ray; 1.90 A; B/D=1-147.
DR   PDB; 1O1K; X-ray; 2.00 A; B/D=1-147.
DR   PDB; 1O1L; X-ray; 1.80 A; B/D=1-147.
DR   PDB; 1O1M; X-ray; 1.85 A; B/D=1-147.
DR   PDB; 1O1N; X-ray; 1.80 A; B/D=1-147.
DR   PDB; 1O1O; X-ray; 1.80 A; B/D=1-147.
DR   PDB; 1O1P; X-ray; 1.80 A; B/D=1-147.
DR   PDB; 1QI8; X-ray; 1.80 A; B/D=3-147.
DR   PDB; 1QSH; X-ray; 1.70 A; B/D=1-147.
DR   PDB; 1QSI; X-ray; 1.70 A; B/D=1-147.
DR   PDB; 1QXD; X-ray; 2.25 A; B/D=1-147.
DR   PDB; 1QXE; X-ray; 1.85 A; B/D=1-147.
DR   PDB; 1R1X; X-ray; 2.15 A; B=1-147.
DR   PDB; 1R1Y; X-ray; 1.80 A; B/D=1-147.
DR   PDB; 1RPS; X-ray; 2.11 A; B/D=1-147.
DR   PDB; 1RQ3; X-ray; 1.91 A; B/D=1-147.
DR   PDB; 1RQ4; X-ray; 2.11 A; B/D=1-147.
DR   PDB; 1RQA; X-ray; 2.11 A; B/D=3-147.
DR   PDB; 1RVW; X-ray; 2.50 A; B=1-147.
DR   PDB; 1SDK; X-ray; 1.80 A; B/D=1-147.
DR   PDB; 1SDL; X-ray; 1.80 A; B/D=1-147.
DR   PDB; 1THB; X-ray; 1.50 A; B/D=1-147.
DR   PDB; 1UIW; X-ray; 1.50 A; B/D/F/H=1-147.
DR   PDB; 1VWT; X-ray; 1.90 A; B/D=1-147.
DR   PDB; 1XXT; X-ray; 1.91 A; B/D=1-147.
DR   PDB; 1XY0; X-ray; 1.99 A; B/D=1-147.
DR   PDB; 1XYE; X-ray; 2.13 A; B/D=1-147.
DR   PDB; 1XZ2; X-ray; 1.90 A; B/D=1-147.
DR   PDB; 1XZ4; X-ray; 2.00 A; B/D=1-147.
DR   PDB; 1XZ5; X-ray; 2.11 A; B/D=1-147.
DR   PDB; 1XZ7; X-ray; 1.90 A; B/D=1-147.
DR   PDB; 1XZU; X-ray; 2.16 A; B/D=1-147.
DR   PDB; 1XZV; X-ray; 2.11 A; B/D=1-147.
DR   PDB; 1Y09; X-ray; 2.25 A; B/D=1-147.
DR   PDB; 1Y0A; X-ray; 2.22 A; B/D=1-147.
DR   PDB; 1Y0C; X-ray; 2.30 A; B/D=1-147.
DR   PDB; 1Y0D; X-ray; 2.10 A; B/D=1-147.
DR   PDB; 1Y0T; X-ray; 2.14 A; B/D=3-147.
DR   PDB; 1Y0W; X-ray; 2.14 A; B/D=3-147.
DR   PDB; 1Y22; X-ray; 2.16 A; B/D=3-147.
DR   PDB; 1Y2Z; X-ray; 2.07 A; B/D=3-147.
DR   PDB; 1Y31; X-ray; 2.13 A; B/D=3-147.
DR   PDB; 1Y35; X-ray; 2.12 A; B/D=3-147.
DR   PDB; 1Y45; X-ray; 2.00 A; B/D=3-147.
DR   PDB; 1Y46; X-ray; 2.22 A; B/D=3-147.
DR   PDB; 1Y4B; X-ray; 2.10 A; B/D=3-147.
DR   PDB; 1Y4F; X-ray; 2.00 A; B/D=3-147.
DR   PDB; 1Y4G; X-ray; 1.91 A; B/D=3-147.
DR   PDB; 1Y4P; X-ray; 1.98 A; B/D=3-147.
DR   PDB; 1Y4Q; X-ray; 2.11 A; B/D=3-147.
DR   PDB; 1Y4R; X-ray; 2.22 A; B/D=3-147.
DR   PDB; 1Y4V; X-ray; 1.84 A; B/D=3-147.
DR   PDB; 1Y5F; X-ray; 2.14 A; B/D=3-147.
DR   PDB; 1Y5J; X-ray; 2.03 A; B/D=3-147.
DR   PDB; 1Y5K; X-ray; 2.20 A; B/D=3-147.
DR   PDB; 1Y7C; X-ray; 2.10 A; B/D=3-147.
DR   PDB; 1Y7D; X-ray; 1.90 A; B/D=3-147.
DR   PDB; 1Y7G; X-ray; 2.10 A; B/D=3-147.
DR   PDB; 1Y7Z; X-ray; 1.98 A; B/D=3-147.
DR   PDB; 1Y83; X-ray; 1.90 A; B/D=3-147.
DR   PDB; 1Y85; X-ray; 2.13 A; B/D=1-146.
DR   PDB; 1Y8W; X-ray; 2.90 A; B/D=1-147.
DR   PDB; 1YDZ; X-ray; 3.30 A; B/D=1-147.
DR   PDB; 1YE0; X-ray; 2.50 A; B/D=3-147.
DR   PDB; 1YE1; X-ray; 4.50 A; B/D=3-147.
DR   PDB; 1YE2; X-ray; 1.80 A; B/D=3-147.
DR   PDB; 1YEN; X-ray; 2.80 A; B/D=3-147.
DR   PDB; 1YEO; X-ray; 2.22 A; B/D=3-147.
DR   PDB; 1YEQ; X-ray; 2.75 A; B/D=3-147.
DR   PDB; 1YEU; X-ray; 2.12 A; B/D=3-147.
DR   PDB; 1YEV; X-ray; 2.11 A; B/D=3-147.
DR   PDB; 1YFF; X-ray; 2.40 A; B/D/F/H=1-147.
DR   PDB; 1YG5; X-ray; 2.70 A; B/D=3-147.
DR   PDB; 1YGD; X-ray; 2.73 A; B/D=3-147.
DR   PDB; 1YGF; X-ray; 2.70 A; B/D=3-147.
DR   PDB; 1YH9; X-ray; 2.20 A; B/D=1-147.
DR   PDB; 1YHE; X-ray; 2.10 A; B/D=1-147.
DR   PDB; 1YHR; X-ray; 2.60 A; B/D=1-147.
DR   PDB; 1YIE; X-ray; 2.40 A; B/D=3-147.
DR   PDB; 1YIH; X-ray; 2.00 A; B/D=3-147.
DR   PDB; 1YVQ; X-ray; 1.80 A; B/D=1-147.
DR   PDB; 1YVT; X-ray; 1.80 A; B=1-147.
DR   PDB; 1YZI; X-ray; 2.07 A; B=1-147.
DR   PDB; 2D5Z; X-ray; 1.45 A; B/D=1-147.
DR   PDB; 2D60; X-ray; 1.70 A; B/D=1-147.
DR   PDB; 2DN1; X-ray; 1.25 A; B=1-147.
DR   PDB; 2DN2; X-ray; 1.25 A; B/D=1-147.
DR   PDB; 2DN3; X-ray; 1.25 A; B=2-147.
DR   PDB; 2DXM; Neutron; 2.10 A; B/D=2-147.
DR   PDB; 2H35; NMR; -; B/D=2-147.
DR   PDB; 2HBC; X-ray; 2.10 A; B=1-147.
DR   PDB; 2HBD; X-ray; 2.20 A; B=1-147.
DR   PDB; 2HBE; X-ray; 2.00 A; B=1-147.
DR   PDB; 2HBF; X-ray; 2.20 A; B=1-147.
DR   PDB; 2HBS; X-ray; 2.05 A; B/D/F/H=1-147.
DR   PDB; 2HCO; X-ray; 2.70 A; B=1-147.
DR   PDB; 2HHD; X-ray; 2.20 A; B/D=1-147.
DR   PDB; 2HHE; X-ray; 2.20 A; B/D=4-147.
DR   PDB; 4HHB; X-ray; 1.74 A; B/D=1-147.
DR   PDB; 6HBW; X-ray; 2.00 A; B/D=1-147.
DR   PDBsum; 1A00; -.
DR   PDBsum; 1A01; -.
DR   PDBsum; 1A0U; -.
DR   PDBsum; 1A0Z; -.
DR   PDBsum; 1A3N; -.
DR   PDBsum; 1A3O; -.
DR   PDBsum; 1ABW; -.
DR   PDBsum; 1ABY; -.
DR   PDBsum; 1AJ9; -.
DR   PDBsum; 1B86; -.
DR   PDBsum; 1BAB; -.
DR   PDBsum; 1BBB; -.
DR   PDBsum; 1BIJ; -.
DR   PDBsum; 1BUW; -.
DR   PDBsum; 1BZ0; -.
DR   PDBsum; 1BZ1; -.
DR   PDBsum; 1BZZ; -.
DR   PDBsum; 1C7B; -.
DR   PDBsum; 1C7C; -.
DR   PDBsum; 1C7D; -.
DR   PDBsum; 1CBL; -.
DR   PDBsum; 1CBM; -.
DR   PDBsum; 1CH4; -.
DR   PDBsum; 1CLS; -.
DR   PDBsum; 1CMY; -.
DR   PDBsum; 1COH; -.
DR   PDBsum; 1DKE; -.
DR   PDBsum; 1DXT; -.
DR   PDBsum; 1DXU; -.
DR   PDBsum; 1DXV; -.
DR   PDBsum; 1FN3; -.
DR   PDBsum; 1G9V; -.
DR   PDBsum; 1GBU; -.
DR   PDBsum; 1GBV; -.
DR   PDBsum; 1GLI; -.
DR   PDBsum; 1GZX; -.
DR   PDBsum; 1HAB; -.
DR   PDBsum; 1HAC; -.
DR   PDBsum; 1HBA; -.
DR   PDBsum; 1HBB; -.
DR   PDBsum; 1HBS; -.
DR   PDBsum; 1HCO; -.
DR   PDBsum; 1HDB; -.
DR   PDBsum; 1HGA; -.
DR   PDBsum; 1HGB; -.
DR   PDBsum; 1HGC; -.
DR   PDBsum; 1HHO; -.
DR   PDBsum; 1IRD; -.
DR   PDBsum; 1J3Y; -.
DR   PDBsum; 1J3Z; -.
DR   PDBsum; 1J40; -.
DR   PDBsum; 1J41; -.
DR   PDBsum; 1J7S; -.
DR   PDBsum; 1J7W; -.
DR   PDBsum; 1J7Y; -.
DR   PDBsum; 1JY7; -.
DR   PDBsum; 1K0Y; -.
DR   PDBsum; 1K1K; -.
DR   PDBsum; 1KD2; -.
DR   PDBsum; 1LFL; -.
DR   PDBsum; 1LFQ; -.
DR   PDBsum; 1LFT; -.
DR   PDBsum; 1LFV; -.
DR   PDBsum; 1LFY; -.
DR   PDBsum; 1LFZ; -.
DR   PDBsum; 1LJW; -.
DR   PDBsum; 1M9P; -.
DR   PDBsum; 1MKO; -.
DR   PDBsum; 1NEJ; -.
DR   PDBsum; 1NIH; -.
DR   PDBsum; 1NQP; -.
DR   PDBsum; 1O1I; -.
DR   PDBsum; 1O1J; -.
DR   PDBsum; 1O1K; -.
DR   PDBsum; 1O1L; -.
DR   PDBsum; 1O1M; -.
DR   PDBsum; 1O1N; -.
DR   PDBsum; 1O1O; -.
DR   PDBsum; 1O1P; -.
DR   PDBsum; 1QI8; -.
DR   PDBsum; 1QSH; -.
DR   PDBsum; 1QSI; -.
DR   PDBsum; 1QXD; -.
DR   PDBsum; 1QXE; -.
DR   PDBsum; 1R1X; -.
DR   PDBsum; 1R1Y; -.
DR   PDBsum; 1RPS; -.
DR   PDBsum; 1RQ3; -.
DR   PDBsum; 1RQ4; -.
DR   PDBsum; 1RQA; -.
DR   PDBsum; 1RVW; -.
DR   PDBsum; 1SDK; -.
DR   PDBsum; 1SDL; -.
DR   PDBsum; 1THB; -.
DR   PDBsum; 1UIW; -.
DR   PDBsum; 1VWT; -.
DR   PDBsum; 1XXT; -.
DR   PDBsum; 1XY0; -.
DR   PDBsum; 1XYE; -.
DR   PDBsum; 1XZ2; -.
DR   PDBsum; 1XZ4; -.
DR   PDBsum; 1XZ5; -.
DR   PDBsum; 1XZ7; -.
DR   PDBsum; 1XZU; -.
DR   PDBsum; 1XZV; -.
DR   PDBsum; 1Y09; -.
DR   PDBsum; 1Y0A; -.
DR   PDBsum; 1Y0C; -.
DR   PDBsum; 1Y0D; -.
DR   PDBsum; 1Y0T; -.
DR   PDBsum; 1Y0W; -.
DR   PDBsum; 1Y22; -.
DR   PDBsum; 1Y2Z; -.
DR   PDBsum; 1Y31; -.
DR   PDBsum; 1Y35; -.
DR   PDBsum; 1Y45; -.
DR   PDBsum; 1Y46; -.
DR   PDBsum; 1Y4B; -.
DR   PDBsum; 1Y4F; -.
DR   PDBsum; 1Y4G; -.
DR   PDBsum; 1Y4P; -.
DR   PDBsum; 1Y4Q; -.
DR   PDBsum; 1Y4R; -.
DR   PDBsum; 1Y4V; -.
DR   PDBsum; 1Y5F; -.
DR   PDBsum; 1Y5J; -.
DR   PDBsum; 1Y5K; -.
DR   PDBsum; 1Y7C; -.
DR   PDBsum; 1Y7D; -.
DR   PDBsum; 1Y7G; -.
DR   PDBsum; 1Y7Z; -.
DR   PDBsum; 1Y83; -.
DR   PDBsum; 1Y85; -.
DR   PDBsum; 1Y8W; -.
DR   PDBsum; 1YDZ; -.
DR   PDBsum; 1YE0; -.
DR   PDBsum; 1YE1; -.
DR   PDBsum; 1YE2; -.
DR   PDBsum; 1YEN; -.
DR   PDBsum; 1YEO; -.
DR   PDBsum; 1YEQ; -.
DR   PDBsum; 1YEU; -.
DR   PDBsum; 1YEV; -.
DR   PDBsum; 1YFF; -.
DR   PDBsum; 1YG5; -.
DR   PDBsum; 1YGD; -.
DR   PDBsum; 1YGF; -.
DR   PDBsum; 1YH9; -.
DR   PDBsum; 1YHE; -.
DR   PDBsum; 1YHR; -.
DR   PDBsum; 1YIE; -.
DR   PDBsum; 1YIH; -.
DR   PDBsum; 1YVQ; -.
DR   PDBsum; 1YVT; -.
DR   PDBsum; 1YZI; -.
DR   PDBsum; 2D5Z; -.
DR   PDBsum; 2D60; -.
DR   PDBsum; 2DN1; -.
DR   PDBsum; 2DN2; -.
DR   PDBsum; 2DN3; -.
DR   PDBsum; 2DXM; -.
DR   PDBsum; 2H35; -.
DR   PDBsum; 2HBC; -.
DR   PDBsum; 2HBD; -.
DR   PDBsum; 2HBE; -.
DR   PDBsum; 2HBF; -.
DR   PDBsum; 2HBS; -.
DR   PDBsum; 2HCO; -.
DR   PDBsum; 2HHD; -.
DR   PDBsum; 2HHE; -.
DR   PDBsum; 4HHB; -.
DR   PDBsum; 6HBW; -.
DR   IntAct; P68871; -.
DR   PhosphoSite; P68871; -.
DR   SWISS-2DPAGE; P68871; -.
DR   HSC-2DPAGE; P68871; -.
DR   PMMA-2DPAGE; P68871; -.
DR   REPRODUCTION-2DPAGE; IPI00654755; -.
DR   REPRODUCTION-2DPAGE; P68871; -.
DR   Siena-2DPAGE; P68871; -.
DR   PeptideAtlas; P68871; -.
DR   Ensembl; ENSG00000188170; Homo sapiens.
DR   GeneID; 3043; -.
DR   KEGG; hsa:3043; -.
DR   HGNC; HGNC:4827; HBB.
DR   MIM; 140700; phenotype.
DR   MIM; 141900; gene+phenotype.
DR   MIM; 603902; phenotype.
DR   MIM; 603903; phenotype.
DR   MIM; 604131; phenotype.
DR   Orphanet; 848; Beta-thalassemia.
DR   Orphanet; 2132; Hemoglobin C disease.
DR   Orphanet; 2133; Hemoglobin E disease.
DR   Orphanet; 232; Sickle cell anaemia.
DR   PharmGKB; PA29202; -.
DR   HOVERGEN; P68871; -.
DR   DrugBank; DB00893; Iron Dextran.
DR   LinkHub; P68871; -.
DR   ArrayExpress; P68871; -.
DR   CleanEx; HS_HBB; -.
DR   GermOnline; ENSG00000188170; Homo sapiens.
DR   GO; GO:0005833; C:hemoglobin complex; TAS:UniProtKB.
DR   GO; GO:0030492; F:hemoglobin binding; IDA:UniProtKB.
DR   GO; GO:0019825; F:oxygen binding; IDA:UniProtKB.
DR   GO; GO:0005344; F:oxygen transporter activity; NAS:UniProtKB.
DR   GO; GO:0030185; P:nitric oxide transport; NAS:UniProtKB.
DR   GO; GO:0015671; P:oxygen transport; TAS:UniProtKB.
DR   GO; GO:0045429; P:positive regulation of nitric oxide biosynt...; NAS:UniProtKB.
DR   InterPro; IPR012292; Globin.
DR   InterPro; IPR000971; Globin_subset.
DR   InterPro; IPR002337; Haemoglobin_b.
DR   Gene3D; G3DSA:1.10.490.10; Globin_related; 1.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00814; BETAHAEM.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Acetylation; Direct protein sequencing;
KW   Disease mutation; Glycation; Glycoprotein; Heme; Hypotensive agent;
KW   Iron; Metal-binding; Oxygen transport; Polymorphism; Pyruvate;
KW   S-nitrosylation; Transport; Vasoactive.
FT   INIT_MET      1      1       Removed.
FT   CHAIN         2    147       Hemoglobin subunit beta.
FT                                /FTId=PRO_0000052976.
FT   PEPTIDE      33     42       LVV-hemorphin-7.
FT                                /FTId=PRO_0000296641.
FT   METAL        64     64       Iron (heme distal ligand).
FT   METAL        93     93       Iron (heme proximal ligand).
FT   BINDING       2      2       2,3-bisphosphoglycerate; via amino
FT                                nitrogen.
FT   BINDING       3      3       2,3-bisphosphoglycerate.
FT   BINDING      83     83       2,3-bisphosphoglycerate.
FT   BINDING     144    144       2,3-bisphosphoglycerate.
FT   SITE         60     60       Not glycated.
FT   SITE         83     83       Not glycated.
FT   SITE         96     96       Not glycated.
FT   SITE        142    142       Susceptible to oxidation; associated with
FT                                variant Atlanta, variant non-spherocytic
FT                                haemolytic anemia and variant
FT                                Christchurch.
FT   SITE        145    145       Aspirin-acetylated lysine.
FT   MOD_RES       2      2       N-acetylalanine; in variant Raleigh.
FT   MOD_RES       2      2       N-pyruvate 2-iminyl-valine; in Hb A1b.
FT   MOD_RES      94     94       S-nitrosocysteine.
FT   CARBOHYD      2      2       N-linked (Glc) (glycation); in Hb A1c.
FT   CARBOHYD      9      9       N-linked (Glc) (glycation).
FT   CARBOHYD     18     18       N-linked (Glc) (glycation).
FT   CARBOHYD     67     67       N-linked (Glc) (glycation).
FT   CARBOHYD    121    121       N-linked (Glc) (glycation).
FT   CARBOHYD    145    145       N-linked (Glc) (glycation).
FT   VARIANT       2      2       V -> A (in Raleigh; O(2) affinity down).
FT                                /FTId=VAR_002856.
FT   VARIANT       3      3       H -> L (in Graz; dbSNP:rs35906307).
FT                                /FTId=VAR_002857.
FT   VARIANT       3      3       H -> Q (in Okayama; O(2) affinity up;
FT                                dbSNP:rs713040).
FT                                /FTId=VAR_002858.
FT   VARIANT       3      3       H -> R (in Deer Lodge; O(2) affinity up).
FT                                /FTId=VAR_002859.
FT   VARIANT       3      3       H -> Y (in Fukuoka).
FT                                /FTId=VAR_002860.
FT   VARIANT       6      6       P -> R (in Warwickshire;
FT                                dbSNP:rs34769005).
FT                                /FTId=VAR_002861.
FT   VARIANT       7      7       E -> A (in G-Makassar).
FT                                /FTId=VAR_002862.
FT   VARIANT       7      7       E -> K (in C).
FT                                /FTId=VAR_002864.
FT   VARIANT       7      7       E -> Q (in Machida).
FT                                /FTId=VAR_002865.
FT   VARIANT       7      7       E -> V (in S; sickle cell anemia;
FT                                dbSNP:rs334).
FT                                /FTId=VAR_002863.
FT   VARIANT       8      8       E -> G (in G-San Jose; mildly unstable;
FT                                dbSNP:rs34948328).
FT                                /FTId=VAR_002866.
FT   VARIANT       8      8       E -> K (in G-Siriraj).
FT                                /FTId=VAR_002867.
FT   VARIANT       9      9       K -> E (in N-Timone; dbSNP:rs33932981).
FT                                /FTId=VAR_002868.
FT   VARIANT       9      9       K -> Q (in J-Luhe).
FT                                /FTId=VAR_002869.
FT   VARIANT       9      9       K -> T (in Rio Grande).
FT                                /FTId=VAR_002870.
FT   VARIANT      10     10       S -> C (in Porto Alegre; O(2) affinity
FT                                up).
FT                                /FTId=VAR_002871.
FT   VARIANT      11     11       A -> D (in Ankara).
FT                                /FTId=VAR_002872.
FT   VARIANT      11     11       A -> V (in Iraq-Halabja).
FT                                /FTId=VAR_025393.
FT   VARIANT      12     12       V -> D (in Windsor; O(2) affinity up;
FT                                unstable; dbSNP:rs33974228).
FT                                /FTId=VAR_002873.
FT   VARIANT      12     12       V -> I (in Hamilton).
FT                                /FTId=VAR_002874.
FT   VARIANT      14     14       A -> D (in J-Lens; dbSNP:rs35203747).
FT                                /FTId=VAR_002875.
FT   VARIANT      15     15       L -> P (in Saki; unstable).
FT                                /FTId=VAR_002876.
FT   VARIANT      15     15       L -> R (in Soegn; unstable).
FT                                /FTId=VAR_002877.
FT   VARIANT      16     16       W -> G (in Randwick; unstable;
FT                                dbSNP:rs33946157).
FT                                /FTId=VAR_002878.
FT   VARIANT      16     16       W -> R (in Belfast; O(2) affinity up;
FT                                unstable).
FT                                /FTId=VAR_002879.
FT   VARIANT      17     17       G -> D (in J-Baltimore/J-Trinidad/J-
FT                                Ireland/J-Georgia/N-New Haven).
FT                                /FTId=VAR_002880.
FT   VARIANT      17     17       G -> R (in D-Bushman).
FT                                /FTId=VAR_002881.
FT   VARIANT      18     18       K -> E (in Nagasaki; dbSNP:rs33986703).
FT                                /FTId=VAR_002882.
FT   VARIANT      18     18       K -> N (in J-Amiens).
FT                                /FTId=VAR_002883.
FT   VARIANT      18     18       K -> Q (in Nikosia).
FT                                /FTId=VAR_002884.
FT   VARIANT      19     19       V -> M (in Baden; slightly unstable;
FT                                dbSNP:rs35802118).
FT                                /FTId=VAR_002885.
FT   VARIANT      20     20       N -> D (in Alamo).
FT                                /FTId=VAR_002886.
FT   VARIANT      20     20       N -> K (in D-Ouleh RABAH).
FT                                /FTId=VAR_002887.
FT   VARIANT      20     20       N -> S (in Malay).
FT                                /FTId=VAR_002888.
FT   VARIANT      21     21       V -> M (in Olympia; O(2) affinity up).
FT                                /FTId=VAR_002889.
FT   VARIANT      22     22       D -> G (in Connecticut; O(2) affinity
FT                                down).
FT                                /FTId=VAR_002890.
FT   VARIANT      22     22       D -> H (in Karlskoga).
FT                                /FTId=VAR_002892.
FT   VARIANT      22     22       D -> N (in Cocody).
FT                                /FTId=VAR_002891.
FT   VARIANT      22     22       D -> Y (in Yusa).
FT                                /FTId=VAR_002893.
FT   VARIANT      23     23       E -> A (in G-Coushatta/G-Saskatoon/G-
FT                                Taegu/Hsin Chu).
FT                                /FTId=VAR_002894.
FT   VARIANT      23     23       E -> G (in G-Taipei).
FT                                /FTId=VAR_002895.
FT   VARIANT      23     23       E -> K (in E-Saskatoon; unstable).
FT                                /FTId=VAR_002896.
FT   VARIANT      23     23       E -> Q (in D-Iran).
FT                                /FTId=VAR_002897.
FT   VARIANT      23     23       E -> V (in D-Granada).
FT                                /FTId=VAR_002898.
FT   VARIANT      24     24       V -> D (in Strasbourg; O(2) affinity up).
FT                                /FTId=VAR_002899.
FT   VARIANT      24     24       V -> F (in Palmerston North; O(2)
FT                                affinity up; unstable).
FT                                /FTId=VAR_002900.
FT   VARIANT      24     24       V -> G (in Miyashiro; O(2) affinity up;
FT                                unstable).
FT                                /FTId=VAR_002901.
FT   VARIANT      25     25       G -> D (in Moscva; O(2) affinity down;
FT                                unstable).
FT                                /FTId=VAR_002902.
FT   VARIANT      25     25       G -> R (in Riverdale-Bronx; O(2) affinity
FT                                up; unstable).
FT                                /FTId=VAR_002903.
FT   VARIANT      25     25       G -> V (in Savannah; unstable).
FT                                /FTId=VAR_002904.
FT   VARIANT      26     26       G -> D (in J-Auckland; unstable; O(2)
FT                                affinity down).
FT                                /FTId=VAR_002905.
FT   VARIANT      26     26       G -> R (in G-Taiwan Ami).
FT                                /FTId=VAR_002906.
FT   VARIANT      27     27       E -> K (in E).
FT                                /FTId=VAR_002907.
FT   VARIANT      27     27       E -> V (in Henri Mondor; slightly
FT                                unstable).
FT                                /FTId=VAR_002908.
FT   VARIANT      28     28       A -> D (in Volga/Drenthe; unstable).
FT                                /FTId=VAR_002909.
FT   VARIANT      28     28       A -> S (in Knossos).
FT                                /FTId=VAR_002910.
FT   VARIANT      28     28       A -> V (in Grange-blanche; O(2) affinity
FT                                up).
FT                                /FTId=VAR_002911.
FT   VARIANT      29     29       L -> P (in Genova/Hyogo; unstable).
FT                                /FTId=VAR_002912.
FT   VARIANT      29     29       L -> Q (in St Louis).
FT                                /FTId=VAR_035236.
FT   VARIANT      30     30       G -> D (in Lufkin; unstable).
FT                                /FTId=VAR_002913.
FT   VARIANT      31     31       R -> S (in Tacoma; unstable).
FT                                /FTId=VAR_002914.
FT   VARIANT      32     32       L -> P (in Yokohama; unstable).
FT                                /FTId=VAR_002915.
FT   VARIANT      33     33       L -> R (in Castilla; unstable).
FT                                /FTId=VAR_002916.
FT   VARIANT      33     33       L -> V (in Muscat; slightly unstable).
FT                                /FTId=VAR_002917.
FT   VARIANT      35     35       V -> D (in Santander; unstable).
FT                                /FTId=VAR_025394.
FT   VARIANT      35     35       V -> F (in Pitie-Salpetriere; O(2)
FT                                affinity up).
FT                                /FTId=VAR_002918.
FT   VARIANT      35     35       V -> L (in Nantes; increased oxygen
FT                                affinity).
FT                                /FTId=VAR_025395.
FT   VARIANT      36     36       Y -> F (in Philly; O(2) affinity up;
FT                                unstable).
FT                                /FTId=VAR_002919.
FT   VARIANT      37     37       P -> R (in Sunnybrook).
FT                                /FTId=VAR_002920.
FT   VARIANT      37     37       P -> S (in North Chicago; O(2) affinity
FT                                up).
FT                                /FTId=VAR_002921.
FT   VARIANT      37     37       P -> T (in Linkoping/Finlandia; O(2)
FT                                affinity up).
FT                                /FTId=VAR_002922.
FT   VARIANT      38     38       W -> G (in Howick).
FT                                /FTId=VAR_002923.
FT   VARIANT      38     38       W -> R (in Rothschild; O(2) affinity
FT                                down).
FT                                /FTId=VAR_002925.
FT   VARIANT      38     38       W -> S (in Hirose; O(2) affinity up).
FT                                /FTId=VAR_002924.
FT   VARIANT      39     39       T -> N (in Hinwil; O(2) affinity up).
FT                                /FTId=VAR_002926.
FT   VARIANT      40     40       Q -> E (in Vaasa; unstable).
FT                                /FTId=VAR_002927.
FT   VARIANT      40     40       Q -> K (in Alabama).
FT                                /FTId=VAR_002928.
FT   VARIANT      40     40       Q -> R (in Tianshui).
FT                                /FTId=VAR_002929.
FT   VARIANT      42     42       F -> Y (in Mequon).
FT                                /FTId=VAR_002930.
FT   VARIANT      42     42       Missing (in Bruxelles).
FT                                /FTId=VAR_035237.
FT   VARIANT      43     43       F -> L (in Louisville; unstable).
FT                                /FTId=VAR_002931.
FT   VARIANT      43     43       F -> S (in Hammersmith).
FT                                /FTId=VAR_035239.
FT   VARIANT      43     43       Missing (in Bruxelles).
FT                                /FTId=VAR_035238.
FT   VARIANT      44     44       E -> Q (in Hoshida/Chaya).
FT                                /FTId=VAR_002932.
FT   VARIANT      45     45       S -> C (in Mississippi).
FT                                /FTId=VAR_002933.
FT   VARIANT      46     46       F -> S (in Cheverly; unstable).
FT                                /FTId=VAR_002934.
FT   VARIANT      47     47       G -> E (in K-Ibadan).
FT                                /FTId=VAR_002935.
FT   VARIANT      48     48       D -> A (in Avicenna).
FT                                /FTId=VAR_002936.
FT   VARIANT      48     48       D -> G (in Gavello).
FT                                /FTId=VAR_002937.
FT   VARIANT      48     48       D -> Y (in Maputo).
FT                                /FTId=VAR_002938.
FT   VARIANT      49     49       L -> P (in Bab-Saadoum; slightly
FT                                unstable).
FT                                /FTId=VAR_002939.
FT   VARIANT      50     50       S -> F (in Las Palmas; slightly
FT                                unstable).
FT                                /FTId=VAR_002940.
FT   VARIANT      51     51       T -> K (in Edmonton).
FT                                /FTId=VAR_002941.
FT   VARIANT      52     52       P -> R (in Willamette; O(2) affinity up;
FT                                unstable).
FT                                /FTId=VAR_002942.
FT   VARIANT      53     53       D -> A (in Ocho Rios).
FT                                /FTId=VAR_002943.
FT   VARIANT      53     53       D -> H (in Summer Hill).
FT                                /FTId=VAR_002944.
FT   VARIANT      55     55       V -> D (in Jacksonville; O(2) affinity
FT                                up; unstable).
FT                                /FTId=VAR_002945.
FT   VARIANT      56     56       M -> K (in Matera; unstable).
FT                                /FTId=VAR_002946.
FT   VARIANT      57     57       G -> R (in Hamadan).
FT                                /FTId=VAR_002947.
FT   VARIANT      58     58       N -> K (in G-ferrara; unstable).
FT                                /FTId=VAR_002948.
FT   VARIANT      59     59       P -> R (in Dhofar/Yukuhashi).
FT                                /FTId=VAR_002949.
FT   VARIANT      60     60       K -> E (in I-High Wycombe).
FT                                /FTId=VAR_002950.
FT   VARIANT      61     61       V -> A (in Collingwood; unstable).
FT                                /FTId=VAR_002951.
FT   VARIANT      62     62       K -> E (in N-Seatlle).
FT                                /FTId=VAR_002952.
FT   VARIANT      62     62       K -> M (in Bologna; O(2) affinity down).
FT                                /FTId=VAR_002953.
FT   VARIANT      62     62       K -> N (in Hikari).
FT                                /FTId=VAR_002954.
FT   VARIANT      63     63       A -> D (in J-Europa).
FT                                /FTId=VAR_002955.
FT   VARIANT      63     63       A -> P (in Duarte; unstable).
FT                                /FTId=VAR_002956.
FT   VARIANT      64     64       H -> Y (in M-Saskatoon; O(2) affinity
FT                                up).
FT                                /FTId=VAR_002957.
FT   VARIANT      66     66       K -> M (in J-Antakya).
FT                                /FTId=VAR_002958.
FT   VARIANT      66     66       K -> N (in J-Sicilia).
FT                                /FTId=VAR_002959.
FT   VARIANT      66     66       K -> Q (in J-Cairo).
FT                                /FTId=VAR_002960.
FT   VARIANT      67     67       K -> T (in Chico; O(2) affinity down).
FT                                /FTId=VAR_002961.
FT   VARIANT      68     68       V -> A (in Sydney; unstable).
FT                                /FTId=VAR_002962.
FT   VARIANT      68     68       V -> D (in Bristol).
FT                                /FTId=VAR_035240.
FT   VARIANT      68     68       V -> G (in non-spherocytic haemolytic
FT                                anemia; Manukau; dbSNP:rs33918343).
FT                                /FTId=VAR_040060.
FT   VARIANT      68     68       V -> M (in Alesha; unstable).
FT                                /FTId=VAR_002963.
FT   VARIANT      69     69       L -> H (in Brisbane; O(2) affinity up).
FT                                /FTId=VAR_002964.
FT   VARIANT      69     69       L -> P (in Mizuho; unstable).
FT                                /FTId=VAR_002965.
FT   VARIANT      70     70       G -> D (in Rambam).
FT                                /FTId=VAR_002966.
FT   VARIANT      70     70       G -> R (in Kenitra).
FT                                /FTId=VAR_002967.
FT   VARIANT      70     70       G -> S (in City of Hope).
FT                                /FTId=VAR_002968.
FT   VARIANT      71     71       A -> D (in Seattle; O(2) affinity down;
FT                                unstable).
FT                                /FTId=VAR_002969.
FT   VARIANT      72     72       F -> S (in Christchurch; unstable).
FT                                /FTId=VAR_002970.
FT   VARIANT      74     74       D -> G (in Tilburg; O(2) affinity down).
FT                                /FTId=VAR_002971.
FT   VARIANT      74     74       D -> V (in Mobile; O(2) affinity down).
FT                                /FTId=VAR_002972.
FT   VARIANT      74     74       D -> Y (in Vancouver; O(2) affinity
FT                                down).
FT                                /FTId=VAR_002973.
FT   VARIANT      75     75       G -> R (in Aalborg; unstable).
FT                                /FTId=VAR_002974.
FT   VARIANT      75     75       G -> V (in Bushwick; unstable).
FT                                /FTId=VAR_002975.
FT   VARIANT      76     76       L -> P (in Atlanta; unstable).
FT                                /FTId=VAR_002976.
FT   VARIANT      76     76       L -> R (in Pasadena; O(2) affinity up;
FT                                unstable).
FT                                /FTId=VAR_002977.
FT   VARIANT      77     77       A -> D (in J-Chicago).
FT                                /FTId=VAR_002978.
FT   VARIANT      78     78       H -> D (in J-Iran).
FT                                /FTId=VAR_002979.
FT   VARIANT      78     78       H -> R (in Costa Rica).
FT                                /FTId=VAR_002980.
FT   VARIANT      78     78       H -> Y (in Fukuyama).
FT                                /FTId=VAR_002981.
FT   VARIANT      79     79       L -> R (in Quin-hai).
FT                                /FTId=VAR_002982.
FT   VARIANT      80     80       D -> Y (in Tampa).
FT                                /FTId=VAR_002983.
FT   VARIANT      81     81       N -> K (in G-Szuhu/Gifu).
FT                                /FTId=VAR_002984.
FT   VARIANT      82     82       L -> H (in La Roche-sur-Yon; unstable and
FT                                O(2) affinity up).
FT                                /FTId=VAR_012663.
FT   VARIANT      82     82       L -> R (in Baylor; unstable).
FT                                /FTId=VAR_002985.
FT   VARIANT      83     83       K -> M (in Helsinki; O(2) affinity up).
FT                                /FTId=VAR_002986.
FT   VARIANT      83     83       K -> N (in Providence).
FT                                /FTId=VAR_012664.
FT   VARIANT      84     84       G -> D (in Pyrgos).
FT                                /FTId=VAR_025396.
FT   VARIANT      84     84       G -> R (in Muskegon).
FT                                /FTId=VAR_002987.
FT   VARIANT      85     85       T -> I (in Kofu).
FT                                /FTId=VAR_002988.
FT   VARIANT      87     87       A -> D (in Olomouc; O(2) affinity up).
FT                                /FTId=VAR_002989.
FT   VARIANT      88     88       T -> I (in Quebec-Chori).
FT                                /FTId=VAR_002990.
FT   VARIANT      88     88       T -> K (in D-Ibadan).
FT                                /FTId=VAR_002991.
FT   VARIANT      88     88       T -> P (in Valletta).
FT                                /FTId=VAR_002992.
FT   VARIANT      89     89       L -> P (in Santa Ana; unstable).
FT                                /FTId=VAR_002993.
FT   VARIANT      89     89       L -> R (in Boras; unstable).
FT                                /FTId=VAR_002994.
FT   VARIANT      90     90       S -> N (in Creteil; O(2) affinity up).
FT                                /FTId=VAR_002995.
FT   VARIANT      90     90       S -> R (in Vanderbilt; O(2) affinity up).
FT                                /FTId=VAR_002996.
FT   VARIANT      91     91       E -> D (in Pierre-Benite; O(2) affinity
FT                                up).
FT                                /FTId=VAR_002997.
FT   VARIANT      91     91       E -> K (in Agenogi; O(2) affinity down).
FT                                /FTId=VAR_002998.
FT   VARIANT      92     92       L -> P (in Sabine; unstable).
FT                                /FTId=VAR_002999.
FT   VARIANT      92     92       L -> R (in Caribbean; O(2) affinity down;
FT                                unstable).
FT                                /FTId=VAR_003000.
FT   VARIANT      93     93       H -> D (in J-Altgelds Gardens; unstable).
FT                                /FTId=VAR_003001.
FT   VARIANT      93     93       H -> N (in Isehara; unstable).
FT                                /FTId=VAR_003002.
FT   VARIANT      93     93       H -> P (in Newcastle and Duino;
FT                                associated with S-104 in Duino;
FT                                unstable).
FT                                /FTId=VAR_003003.
FT   VARIANT      93     93       H -> Q (in Istambul; O(2) affinity up;
FT                                unstable).
FT                                /FTId=VAR_003004.
FT   VARIANT      94     94       C -> R (in Okazaki; O(2) affinity up;
FT                                unstable).
FT                                /FTId=VAR_003005.
FT   VARIANT      95     95       D -> G (in Chandigarh).
FT                                /FTId=VAR_003006.
FT   VARIANT      95     95       D -> H (in Barcelona; O(2) affinity up).
FT                                /FTId=VAR_003007.
FT   VARIANT      95     95       D -> N (in Bunbury; O(2) affinity up).
FT                                /FTId=VAR_003008.
FT   VARIANT      96     96       K -> M (in J-Cordoba).
FT                                /FTId=VAR_003009.
FT   VARIANT      96     96       K -> N (in Detroit).
FT                                /FTId=VAR_003010.
FT   VARIANT      97     97       L -> P (in Debrousse; unstable; O(2)
FT                                affinity up).
FT                                /FTId=VAR_003011.
FT   VARIANT      97     97       L -> V (in Regina; O(2) affinity up).
FT                                /FTId=VAR_003012.
FT   VARIANT      98     98       H -> L (in Wood; O(2) affinity up).
FT                                /FTId=VAR_003013.
FT   VARIANT      98     98       H -> P (in Nagoya; O(2) affinity up;
FT                                unstable).
FT                                /FTId=VAR_003014.
FT   VARIANT      98     98       H -> Q (in Malmoe; O(2) affinity up).
FT                                /FTId=VAR_003015.
FT   VARIANT      98     98       H -> Y (in Moriguchi).
FT                                /FTId=VAR_003016.
FT   VARIANT      99     99       V -> G (in Nottingham; unstable).
FT                                /FTId=VAR_003017.
FT   VARIANT     100    100       D -> E (in Coimbra; O(2) affinity up).
FT                                /FTId=VAR_003018.
FT   VARIANT     101    101       P -> L (in Brigham; O(2) affinity up).
FT                                /FTId=VAR_003019.
FT   VARIANT     101    101       P -> R (in New Mexico).
FT                                /FTId=VAR_003020.
FT   VARIANT     102    102       E -> D (in Potomac; O(2) affinity up).
FT                                /FTId=VAR_003021.
FT   VARIANT     102    102       E -> G (in Alberta; O(2) affinity up).
FT                                /FTId=VAR_003022.
FT   VARIANT     102    102       E -> K (in British Columbia; O(2)
FT                                affinity up).
FT                                /FTId=VAR_003023.
FT   VARIANT     102    102       E -> Q (in Rush; unstable).
FT                                /FTId=VAR_003024.
FT   VARIANT     103    103       N -> S (in Beth Israel; O(2) affinity
FT                                down; unstable).
FT                                /FTId=VAR_003025.
FT   VARIANT     103    103       N -> Y (in St Mande; O(2) affinity down).
FT                                /FTId=VAR_003026.
FT   VARIANT     104    104       F -> L (in Heathrow; O(2) affinity up).
FT                                /FTId=VAR_003027.
FT   VARIANT     105    105       R -> S (in Camperdown and Duino;
FT                                associated with P-92 in Duino; unstable).
FT                                /FTId=VAR_003028.
FT   VARIANT     105    105       R -> T (in Sherwood Forest).
FT                                /FTId=VAR_003029.
FT   VARIANT     108    108       G -> R (in Burke; O(2) affinity down;
FT                                unstable).
FT                                /FTId=VAR_003030.
FT   VARIANT     109    109       N -> K (in Presbyterian; O(2) affinity
FT                                down; unstable).
FT                                /FTId=VAR_003031.
FT   VARIANT     110    110       V -> M (in San Diego; O(2) affinity up).
FT                                /FTId=VAR_003032.
FT   VARIANT     111    111       L -> P (in Showa-Yakushiji).
FT                                /FTId=VAR_003033.
FT   VARIANT     112    112       V -> A (in Stanmore; O(2) affinity down;
FT                                unstable).
FT                                /FTId=VAR_003034.
FT   VARIANT     113    113       C -> F (in Canterbury).
FT                                /FTId=VAR_025397.
FT   VARIANT     113    113       C -> R (in Indianapolis).
FT                                /FTId=VAR_003035.
FT   VARIANT     113    113       C -> Y (in Yahata).
FT                                /FTId=VAR_003036.
FT   VARIANT     115    115       L -> M (in Zengcheng).
FT                                /FTId=VAR_010144.
FT   VARIANT     115    115       L -> P (in Durham-N.C./Brescia; causes
FT                                beta-thalassemia).
FT                                /FTId=VAR_010145.
FT   VARIANT     116    116       A -> D (in Hradec Kralove; unstable;
FT                                causes severe beta-thalassemia).
FT                                /FTId=VAR_003037.
FT   VARIANT     116    116       A -> P (in Madrid; unstable).
FT                                /FTId=VAR_003038.
FT   VARIANT     117    117       H -> L (in Vexin; increased oxygen
FT                                affinity).
FT                                /FTId=VAR_025398.
FT   VARIANT     117    117       H -> Q (in Hafnia).
FT                                /FTId=VAR_003039.
FT   VARIANT     118    118       H -> P (in Saitama; unstable).
FT                                /FTId=VAR_003040.
FT   VARIANT     118    118       H -> R (in P-Galveston).
FT                                /FTId=VAR_003041.
FT   VARIANT     118    118       H -> Y (in Tsukumi).
FT                                /FTId=VAR_025399.
FT   VARIANT     120    120       G -> A (in Iowa).
FT                                /FTId=VAR_003042.
FT   VARIANT     121    121       K -> E (in Hijiyama).
FT                                /FTId=VAR_003043.
FT   VARIANT     121    121       K -> I (in Jianghua).
FT                                /FTId=VAR_003044.
FT   VARIANT     121    121       K -> Q (in Takamatsu).
FT                                /FTId=VAR_003045.
FT   VARIANT     122    122       E -> A (in D-Neath).
FT                                /FTId=VAR_003046.
FT   VARIANT     122    122       E -> G (in St Francis).
FT                                /FTId=VAR_003047.
FT   VARIANT     122    122       E -> K (in O-Arab).
FT                                /FTId=VAR_003049.
FT   VARIANT     122    122       E -> Q (in D-Los Angeles/D-Punjab/D-
FT                                Portugal/D-Chicago/D-Oak Ridge).
FT                                /FTId=VAR_003048.
FT   VARIANT     122    122       E -> V (in D-Camperdown/Beograd).
FT                                /FTId=VAR_003050.
FT   VARIANT     124    124       T -> I (in Villejuif; asymptomatic
FT                                variant).
FT                                /FTId=VAR_003051.
FT   VARIANT     125    125       P -> Q (in Ty Gard; O(2) affinity up).
FT                                /FTId=VAR_003053.
FT   VARIANT     125    125       P -> R (in Khartoum; unstable).
FT                                /FTId=VAR_003052.
FT   VARIANT     125    125       P -> S (in Tunis).
FT                                /FTId=VAR_003054.
FT   VARIANT     127    127       V -> A (in Beirut).
FT                                /FTId=VAR_003055.
FT   VARIANT     127    127       V -> E (in Hofu; unstable).
FT                                /FTId=VAR_003057.
FT   VARIANT     127    127       V -> G (in Dhonburi/Neapolis; unstable;
FT                                beta-thalassemia).
FT                                /FTId=VAR_003056.
FT   VARIANT     128    128       Q -> E (in Complutense).
FT                                /FTId=VAR_003058.
FT   VARIANT     128    128       Q -> K (in Brest; unstable).
FT                                /FTId=VAR_003059.
FT   VARIANT     129    129       A -> D (in J-Guantanamo; unstable).
FT                                /FTId=VAR_003060.
FT   VARIANT     130    130       A -> P (in Crete; O(2) affinity up;
FT                                unstable).
FT                                /FTId=VAR_003061.
FT   VARIANT     130    130       A -> V (in La Desirade; O(2) affinity
FT                                down; unstable).
FT                                /FTId=VAR_003062.
FT   VARIANT     131    131       Y -> D (in Wien; unstable).
FT                                /FTId=VAR_003063.
FT   VARIANT     131    131       Y -> S (in Nevers).
FT                                /FTId=VAR_003064.
FT   VARIANT     132    132       Q -> E (in Camden/Tokuchi/Motown).
FT                                /FTId=VAR_003065.
FT   VARIANT     132    132       Q -> K (in Shelby/Leslie/Deaconess;
FT                                unstable).
FT                                /FTId=VAR_003066.
FT   VARIANT     132    132       Q -> P (in Shangai; unstable).
FT                                /FTId=VAR_003067.
FT   VARIANT     132    132       Q -> R (in Sarrebourg; unstable).
FT                                /FTId=VAR_003068.
FT   VARIANT     133    133       K -> N (in Yamagata; O(2) affinity down).
FT                                /FTId=VAR_003069.
FT   VARIANT     133    133       K -> Q (in K-Woolwich).
FT                                /FTId=VAR_003070.
FT   VARIANT     134    134       V -> L (in Extredemura).
FT                                /FTId=VAR_003071.
FT   VARIANT     135    135       V -> E (in North Shore-Caracas;
FT                                unstable).
FT                                /FTId=VAR_003072.
FT   VARIANT     136    136       A -> E (in Beckman; O(2) affinity down;
FT                                unstable).
FT                                /FTId=VAR_003073.
FT   VARIANT     136    136       A -> P (in Altdorf; O(2) affinity up;
FT                                unstable).
FT                                /FTId=VAR_003074.
FT   VARIANT     137    137       G -> D (in Hope; O(2) affinity down;
FT                                unstable).
FT                                /FTId=VAR_003075.
FT   VARIANT     139    139       A -> P (in Brockton; unstable).
FT                                /FTId=VAR_003076.
FT   VARIANT     140    140       N -> D (in Geelong; unstable).
FT                                /FTId=VAR_003077.
FT   VARIANT     140    140       N -> K (in Hinsdale; O(2) affinity down).
FT                                /FTId=VAR_003078.
FT   VARIANT     140    140       N -> S (in S-Wake; associated with V-6).
FT                                /FTId=VAR_025335.
FT   VARIANT     140    140       N -> Y (in Aurora; O(2) affinity up).
FT                                /FTId=VAR_003079.
FT   VARIANT     141    141       A -> D (in Himeji; unstable; O(2)
FT                                affinity down).
FT                                /FTId=VAR_003080.
FT   VARIANT     141    141       A -> T (in St Jacques: O(2) affinity up).
FT                                /FTId=VAR_003081.
FT   VARIANT     141    141       A -> V (in Puttelange; polycythemia; O(2)
FT                                affinity up).
FT                                /FTId=VAR_003082.
FT   VARIANT     142    142       L -> R (in Olmsted; unstable).
FT                                /FTId=VAR_003083.
FT   VARIANT     143    143       A -> D (in Ohio; O(2) affinity up).
FT                                /FTId=VAR_003084.
FT   VARIANT     144    144       H -> D (in Rancho Mirage).
FT                                /FTId=VAR_003085.
FT   VARIANT     144    144       H -> P (in Syracuse; O(2) affinity up).
FT                                /FTId=VAR_003087.
FT   VARIANT     144    144       H -> Q (in Little Rock; O(2) affinity
FT                                up).
FT                                /FTId=VAR_003086.
FT   VARIANT     144    144       H -> R (in Abruzzo; O(2) affinity up).
FT                                /FTId=VAR_003088.
FT   VARIANT     145    145       K -> E (in Mito; O(2) affinity up).
FT                                /FTId=VAR_003089.
FT   VARIANT     146    146       Y -> C (in Rainier; O(2) affinity up).
FT                                /FTId=VAR_003090.
FT   VARIANT     146    146       Y -> H (in Bethesda; O(2) affinity up).
FT                                /FTId=VAR_003091.
FT   VARIANT     147    147       H -> D (in Hiroshima; O(2) affinity up).
FT                                /FTId=VAR_003092.
FT   VARIANT     147    147       H -> L (in Cowtown; O(2) affinity up).
FT                                /FTId=VAR_003093.
FT   VARIANT     147    147       H -> P (in York; O(2) affinity up).
FT                                /FTId=VAR_003094.
FT   VARIANT     147    147       H -> Q (in Kodaira; O(2) affinity up).
FT                                /FTId=VAR_003095.
FT   HELIX         6     16
FT   TURN         21     23
FT   HELIX        24     35
FT   HELIX        37     42
FT   HELIX        44     46
FT   HELIX        52     57
FT   HELIX        59     77
FT   TURN         78     80
FT   HELIX        82     94
FT   TURN         95     97
FT   HELIX       102    119
FT   HELIX       120    122
FT   HELIX       125    142
FT   HELIX       144    146
SQ   SEQUENCE   147 AA;  15998 MW;  A31F6D621C6556A1 CRC64;
     MVHLTPEEKS AVTALWGKVN VDEVGGEALG RLLVVYPWTQ RFFESFGDLS TPDAVMGNPK
     VKAHGKKVLG AFSDGLAHLD NLKGTFATLS ELHCDKLHVD PENFRLLGNV LVCVLAHHFG
     KEFTPPVQAA YQKVVAGVAN ALAHKYH
//
