>YAL001C TFC3 SGDID:S000000001, Chr I from 151006-147594,151166-151097, reverse complement, Verified ORF, "Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding"
>YAL002W VPS8 SGDID:S000000002, Chr I from 143707-147531, Verified ORF, "Membrane-associated protein that interacts with Vps21p to facilitate soluble vacuolar protein localization; component of the CORVET complex; required for localization and trafficking of the CPY sorting receptor; contains RING finger motif"
>YAL003W EFB1 SGDID:S000000003, Chr I from 142174-142253,142620-143160, Verified ORF, "Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site"
>YAL004W YAL004W SGDID:S000002136, Chr I from 140760-141407, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C"
>YAL005C SSA1 SGDID:S000000004, Chr I from 141431-139503, reverse complement, Verified ORF, "ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall"
>YAL007C ERP2 SGDID:S000000005, Chr I from 138345-137698, reverse complement, Verified ORF, "Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles"
>YAL008W FUN14 SGDID:S000000006, Chr I from 136914-137510, Verified ORF, "Mitochondrial protein of unknown function"
>YAL009W SPO7 SGDID:S000000007, Chr I from 135854-136633, Verified ORF, "Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation"
>YAL010C MDM10 SGDID:S000000008, Chr I from 135665-134184, reverse complement, Verified ORF, "Subunit of both the ERMES complex that links the ER to mitochondria, and of the mitochondrial sorting and assembly machinery (SAM complex) that functions in import and assembly of outer membrane beta-barrel proteins"
>YAL011W SWC3 SGDID:S000000009, Chr I from 132199-134076, Verified ORF, "Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae"
>YAL012W CYS3 SGDID:S000000010, Chr I from 130799-131983, Verified ORF, "Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine"
>YAL013W DEP1 SGDID:S000000011, Chr I from 129270-130487, Verified ORF, "Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation"
>YAL014C SYN8 SGDID:S000000012, Chr I from 129019-128252, reverse complement, Verified ORF, "Endosomal SNARE related to mammalian syntaxin 8"
>YAL015C NTG1 SGDID:S000000013, Chr I from 128102-126903, reverse complement, Verified ORF, "DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress"
>YAL016C-A YAL016C-A SGDID:S000028728, Chr I from 125069-124755, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YAL016C-B YAL016C-B SGDID:S000028528, Chr I from 124492-124307, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YAL016W TPD3 SGDID:S000000014, Chr I from 124879-126786, Verified ORF, "Regulatory subunit A of the heterotrimeric protein phosphatase 2A (PP2A), which also contains regulatory subunit Cdc55p and either catalytic subunit Pph21p or Pph22p; required for cell morphogenesis and transcription by RNA polymerase III"
>YAL017W PSK1 SGDID:S000000015, Chr I from 120225-124295, Verified ORF, "One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status"
>YAL018C YAL018C SGDID:S000000016, Chr I from 119541-118564, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YAL019W FUN30 SGDID:S000000017, Chr I from 114919-118314, Verified ORF, "Conserved member of the Snf2p family with ATP-dependent chromatin remodeling activity; has a role in silencing; potential Cdc28p substrate; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies"
>YAL019W-A YAL019W-A SGDID:S000028729, Chr I from 114250-114819, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YAL020C ATS1 SGDID:S000000018, Chr I from 114615-113614, reverse complement, Verified ORF, "Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle"
>YAL021C CCR4 SGDID:S000000019, Chr I from 113359-110846, reverse complement, Verified ORF, "Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening"
>YAL022C FUN26 SGDID:S000000020, Chr I from 110430-108877, reverse complement, Verified ORF, "Nucleoside transporter with broad nucleoside selectivity; localized to intracellular membranes"
>YAL023C PMT2 SGDID:S000000021, Chr I from 108551-106272, reverse complement, Verified ORF, "Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein Ser/Thr residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5; target for new antifungal"
>YAL024C LTE1 SGDID:S000000022, Chr I from 105872-101565, reverse complement, Verified ORF, "Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures"
>YAL025C MAK16 SGDID:S000000023, Chr I from 101145-100225, reverse complement, Verified ORF, "Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus"
>YAL026C DRS2 SGDID:S000000024, Chr I from 99697-95630, reverse complement, Verified ORF, "Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease"
>YAL026C-A YAL026C-A SGDID:S000028730, Chr I from 95823-95386, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAL027W and the verified gene DRS2"
>YAL027W SAW1 SGDID:S000000025, Chr I from 94687-95472, Verified ORF, "Protein involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during double-strand break repair via single-strand annealing; green fluorescent protein (GFP)-fusion protein localizes to the nucleus"
>YAL028W FRT2 SGDID:S000000026, Chr I from 92900-94486, Verified ORF, "Tail-anchored ER membrane protein, interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate"
>YAL029C MYO4 SGDID:S000000027, Chr I from 92270-87855, reverse complement, Verified ORF, "One of two type V myosin motors (along with MYO2) involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p"
>YAL030W SNC1 SGDID:S000000028, Chr I from 87286-87387,87501-87752, Verified ORF, "Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins"
>YAL031C GIP4 SGDID:S000000029, Chr I from 87031-84749, reverse complement, Verified ORF, "Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate"
>YAL031W-A YAL031W-A SGDID:S000028731, Chr I from 84669-84977, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YAL032C PRP45 SGDID:S000000030, Chr I from 84474-83335, reverse complement, Verified ORF, "Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene"
>YAL033W POP5 SGDID:S000000031, Chr I from 82706-83227, Verified ORF, "Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends"
>YAL034C FUN19 SGDID:S000002134, Chr I from 81951-80710, reverse complement, Verified ORF, "Non-essential protein of unknown function; expression induced in response to heat stress"
>YAL034C-B YAL034C-B SGDID:S000002137, Chr I from 79842-79489, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YAL034W-A MTW1 SGDID:S000000032, Chr I from 79718-80587, Verified ORF, "Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly"
>YAL035W FUN12 SGDID:S000000033, Chr I from 76427-79435, Verified ORF, "GTPase, required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; homolog of bacterial IF2"
>YAL036C RBG1 SGDID:S000000034, Chr I from 76152-75043, reverse complement, Verified ORF, "Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid"
>YAL037C-A YAL037C-A SGDID:S000028732, Chr I from 73518-73426, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YAL037C-B YAL037C-B SGDID:S000028592, Chr I from 73300-72326, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YAL037W YAL037W SGDID:S000000035, Chr I from 74020-74823, Uncharacterized ORF, "Putative protein of unknown function"
>YAL038W CDC19 SGDID:S000000036, Chr I from 71786-73288, Verified ORF, "Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration"
>YAL039C CYC3 SGDID:S000000037, Chr I from 69525-68716, reverse complement, Verified ORF, "Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)"
>YAL040C CLN3 SGDID:S000000038, Chr I from 67520-65778, reverse complement, Verified ORF, "G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis"
>YAL041W CDC24 SGDID:S000000039, Chr I from 62840-65404, Verified ORF, "Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing"
>YAL042C-A YAL042C-A SGDID:S000002138, Chr I from 61608-61231, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ERV46/YAL042W; YAL042C-A is a non-essential gene"
>YAL042W ERV46 SGDID:S000000040, Chr I from 61316-62563, Verified ORF, "Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport"
>YAL043C PTA1 SGDID:S000000041, Chr I from 61052-58695, reverse complement, Verified ORF, "Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII"
>YAL044C GCV3 SGDID:S000000042, Chr I from 58462-57950, reverse complement, Verified ORF, "H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF"
>YAL044W-A YAL044W-A SGDID:S000007586, Chr I from 57518-57850, Uncharacterized ORF, "Putative protein of unknown function; similar to S. pombe uvi31 which is a putative DNA repair protein"
>YAL045C YAL045C SGDID:S000000043, Chr I from 57796-57488, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A"
>YAL046C AIM1 SGDID:S000000044, Chr I from 57385-57029, reverse complement, Verified ORF, "Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss"
>YAL047C SPC72 SGDID:S000000045, Chr I from 56857-54989, reverse complement, Verified ORF, "Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization"
>YAL047W-A YAL047W-A SGDID:S000028733, Chr I from 54584-54913, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YAL048C GEM1 SGDID:S000000046, Chr I from 54789-52801, reverse complement, Verified ORF, "Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; not required for pheromone-induced cell death"
>YAL049C AIM2 SGDID:S000000047, Chr I from 52595-51855, reverse complement, Verified ORF, "Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor"
>YAL051W OAF1 SGDID:S000000048, Chr I from 48564-51707, Verified ORF, "Oleate-activated transcription factor, acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis"
>YAL053W FLC2 SGDID:S000000049, Chr I from 45899-48250, Verified ORF, "Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance"
>YAL054C ACS1 SGDID:S000000050, Chr I from 45022-42881, reverse complement, Verified ORF, "Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions"
>YAL055W PEX22 SGDID:S000000051, Chr I from 42177-42719, Verified ORF, "Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation"
>YAL056C-A YAL056C-A SGDID:S000002139, Chr I from 39046-38696, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YAL056W GPB2 SGDID:S000000052, Chr I from 39259-41901, Verified ORF, "Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb1p"
>YAL058W CNE1 SGDID:S000000054, Chr I from 37464-38972, Verified ORF, "Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast"
>YAL059C-A YAL059C-A SGDID:S000028734, Chr I from 36918-36496, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene ECM1/YAL059W"
>YAL059W ECM1 SGDID:S000000055, Chr I from 36509-37147, Verified ORF, "Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm"
>YAL060W BDH1 SGDID:S000000056, Chr I from 35155-36303, Verified ORF, "NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source"
>YAL061W BDH2 SGDID:S000000057, Chr I from 33448-34701, Uncharacterized ORF, "Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3"
>YAL062W GDH3 SGDID:S000000058, Chr I from 31567-32940, Verified ORF, "NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources"
>YAL063C FLO9 SGDID:S000000059, Chr I from 27968-24000, reverse complement, Verified ORF, "Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation"
>YAL063C-A YAL063C-A SGDID:S000028813, Chr I from 22685-22395, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by expression profiling and mass spectrometry"
>YAL064C-A YAL064C-A SGDID:S000002140, Chr I from 13743-13363, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; YAL064C-A is not an essential gene"
>YAL064W YAL064W SGDID:S000000060, Chr I from 21566-21850, Verified ORF, "Protein of unknown function; may interact with ribosomes, based on co-purification experiments"
>YAL064W-B YAL064W-B SGDID:S000002141, Chr I from 12046-12426, Uncharacterized ORF, "Fungal-specific protein of unknown function"
>YAL065C YAL065C SGDID:S000001817, Chr I from 11951-11565, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; has homology to FLO1; possible pseudogene"
>YAL066W YAL066W SGDID:S000000061, Chr I from 10091-10399, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YAL067C SEO1 SGDID:S000000062, Chr I from 9016-7235, reverse complement, Verified ORF, "Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide"
>YAL067W-A YAL067W-A SGDID:S000028593, Chr I from 2480-2707, Uncharacterized ORF, "Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YAL068C PAU8 SGDID:S000002142, Chr I from 2169-1807, reverse complement, Verified ORF, "Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions"
>YAL068W-A YAL068W-A SGDID:S000028594, Chr I from 538-792, Dubious ORF, "Dubious open reading frame unlikely to encode a protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YAL069W YAL069W SGDID:S000002143, Chr I from 335-649, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YAR002C-A ERP1 SGDID:S000002129, Chr I from 154724-154065, reverse complement, Verified ORF, "Protein that forms a heterotrimeric complex with Erp2p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles"
>YAR002W NUP60 SGDID:S000000063, Chr I from 152257-153876, Verified ORF, "Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; involved in nuclear export and cytoplasmic localization of specific mRNAs such as ASH1"
>YAR003W SWD1 SGDID:S000000064, Chr I from 155005-156285, Verified ORF, "Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7"
>YAR007C RFA1 SGDID:S000000065, Chr I from 158619-156754, reverse complement, Verified ORF, "Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination"
>YAR008W SEN34 SGDID:S000000066, Chr I from 158966-159793, Verified ORF, "Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease"
>YAR009C YAR009C SGDID:S000000067, Chr I from 164187-160597, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; in YARCTY1-1 TYB is mutant and probably non-functional"
>YAR010C YAR010C SGDID:S000000068, Chr I from 165866-164544, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; in YARCTY1-1 TYB is mutant and probably non-functional"
>YAR014C BUD14 SGDID:S000000069, Chr I from 168871-166742, reverse complement, Verified ORF, "Protein involved in bud-site selection, Bud14p-Glc7p complex is a cortical regulator of dynein; inhibitor of the actin assembly factor Bnr1p (formin); diploid mutants display a random budding pattern instead of the wild-type bipolar pattern"
>YAR015W ADE1 SGDID:S000000070, Chr I from 169375-170295, Verified ORF, "N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine"
>YAR018C KIN3 SGDID:S000000071, Chr I from 171703-170396, reverse complement, Verified ORF, "Nonessential protein kinase with unknown cellular role"
>YAR019C CDC15 SGDID:S000000072, Chr I from 175135-172211, reverse complement, Verified ORF, "Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II"
>YAR019W-A YAR019W-A SGDID:S000028735, Chr I from 174998-175330, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YAR020C PAU7 SGDID:S000000073, Chr I from 177023-176856, reverse complement, Verified ORF, "Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme"
>YAR023C YAR023C SGDID:S000000074, Chr I from 179820-179281, reverse complement, Uncharacterized ORF, "Putative integral membrane protein, member of DUP240 gene family"
>YAR027W UIP3 SGDID:S000000075, Chr I from 183770-184477, Verified ORF, "Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family"
>YAR028W YAR028W SGDID:S000000076, Chr I from 184892-185596, Uncharacterized ORF, "Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS"
>YAR029W YAR029W SGDID:S000000077, Chr I from 186321-186545, Uncharacterized ORF, "Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern"
>YAR030C YAR030C SGDID:S000001821, Chr I from 186853-186512, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9"
>YAR031W PRM9 SGDID:S000000078, Chr I from 186836-187732, Verified ORF, "Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family"
>YAR033W MST28 SGDID:S000000079, Chr I from 188107-188811, Verified ORF, "Putative integral membrane protein, involved in vesicle formation; forms complex with Mst27p; member of DUP240 gene family; binds COPI and COPII vesicles"
>YAR035C-A YAR035C-A SGDID:S000028595, Chr I from 192417-192337, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; predicted to have a role in cell budding based on computational "guilt by association" analysis"
>YAR035W YAT1 SGDID:S000000080, Chr I from 190193-192256, Verified ORF, "Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated"
>YAR042W SWH1 SGDID:S000000081, Chr I from 192619-196185, Verified ORF, "Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction"
>YAR047C YAR047C SGDID:S000000083, Chr I from 201787-201467, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YAR050W FLO1 SGDID:S000000084, Chr I from 203403-208016, Verified ORF, "Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p"
>YAR053W YAR053W SGDID:S000000085, Chr I from 208367-208663, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YAR060C YAR060C SGDID:S000000086, Chr I from 217492-217157, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YAR061W YAR061W SGDID:S000000087, Chr I from 218140-218343, pseudogene, "Pseudogene with similarity to Flo1p, which is a lectin-like protein involved in flocculation"
>YAR062W YAR062W SGDID:S000000088, Chr I from 218549-219145, pseudogene, "Pseudogene with similarity to Flo1p, which is a lectin-like protein involved in flocculation"
>YAR064W YAR064W SGDID:S000000089, Chr I from 220198-220497, Uncharacterized ORF, "Putative protein of unknown function"
>YAR066W YAR066W SGDID:S000002144, Chr I from 221049-221660, Uncharacterized ORF, "Putative GPI protein"
>YAR068W YAR068W SGDID:S000000091, Chr I from 222406-222891, Uncharacterized ORF, "Fungal-specific protein of unknown function; induced in respiratory-deficient cells"
>YAR069C YAR069C SGDID:S000000092, Chr I from 224304-224011, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YAR070C YAR070C SGDID:S000000093, Chr I from 224862-224563, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YAR071W PHO11 SGDID:S000000094, Chr I from 225460-226863, Verified ORF, "One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2"
>YAR073W IMD1 SGDID:S000000095, Chr I from 227742-228953, Dubious ORF, "Nonfunctional protein with homology to IMP dehydrogenase; probable pseudogene, located close to the telomere; is not expressed at detectable levels; YAR073W and YAR075W comprise a continuous reading frame in some strains of S. cerevisiae"
>YAR075W YAR075W SGDID:S000002145, Chr I from 228844-229317, Dubious ORF, "Non-functional protein with homology IMP dehydrogenase; YAR073W/IMD1 and YAR075W comprise a continuous reading frame in some strains of S. cerevisiae."
>YBL001C ECM15 SGDID:S000000097, Chr II from 237467-237153, reverse complement, Verified ORF, "Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis"
>YBL002W HTB2 SGDID:S000000098, Chr II from 236492-236887, Verified ORF, "Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation"
>YBL003C HTA2 SGDID:S000000099, Chr II from 235792-235394, reverse complement, Verified ORF, "Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p"
>YBL004W UTP20 SGDID:S000000100, Chr II from 227636-235117, Verified ORF, "Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA"
>YBL005W PDR3 SGDID:S000000101, Chr II from 217470-220400, Verified ORF, "Transcriptional activator of the pleiotropic drug resistance network, regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements)"
>YBL005W-A YBL005W-A SGDID:S000002146, Chr II from 221330-222652, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YBL005W-B YBL005W-B SGDID:S000002147, Chr II from 221330-222634,222636-226598, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YBL006C LDB7 SGDID:S000000102, Chr II from 217129-216587, reverse complement, Verified ORF, "Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions"
>YBL006W-A YBL006W-A SGDID:S000028596, Chr II from 216711-216860, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene LDB7/YBL006C"
>YBL007C SLA1 SGDID:S000000103, Chr II from 216366-212632, reverse complement, Verified ORF, "Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains"
>YBL008W HIR1 SGDID:S000000104, Chr II from 209653-212175, Verified ORF, "Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores"
>YBL008W-A YBL008W-A SGDID:S000028529, Chr II from 209409-209648, Uncharacterized ORF, "Putative protein of unknown function; identified by fungal homology and RT-PCR"
>YBL009W ALK2 SGDID:S000000105, Chr II from 207194-209224, Verified ORF, "Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk1p and to mammalian haspins"
>YBL010C YBL010C SGDID:S000000106, Chr II from 206949-206107, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles"
>YBL011W SCT1 SGDID:S000000107, Chr II from 203538-205817, Verified ORF, "Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed"
>YBL012C YBL012C SGDID:S000000108, Chr II from 203807-203406, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YBL013W FMT1 SGDID:S000000109, Chr II from 202056-203261, Verified ORF, "Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate"
>YBL014C RRN6 SGDID:S000000110, Chr II from 201748-199064, reverse complement, Verified ORF, "Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p"
>YBL015W ACH1 SGDID:S000000111, Chr II from 194122-195702, Verified ORF, "Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth"
>YBL016W FUS3 SGDID:S000000112, Chr II from 192451-193512, Verified ORF, "Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its degradation"
>YBL017C PEP1 SGDID:S000000113, Chr II from 191583-186844, reverse complement, Verified ORF, "Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments"
>YBL018C POP8 SGDID:S000000114, Chr II from 186352-185998,186474-186428, reverse complement, Verified ORF, "Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends"
>YBL019W APN2 SGDID:S000000115, Chr II from 184353-185915, Verified ORF, "Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII"
>YBL020W RFT1 SGDID:S000000116, Chr II from 182401-184125, Verified ORF, "Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein"
>YBL021C HAP3 SGDID:S000000117, Chr II from 182094-181660, reverse complement, Verified ORF, "Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding"
>YBL022C PIM1 SGDID:S000000118, Chr II from 181275-177874, reverse complement, Verified ORF, "ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria"
>YBL023C MCM2 SGDID:S000000119, Chr II from 177526-174920, reverse complement, Verified ORF, "Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex"
>YBL024W NCL1 SGDID:S000000120, Chr II from 172534-174588, Verified ORF, "S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; similar to Nop2p and human proliferation associated nucleolar protein p120"
>YBL025W RRN10 SGDID:S000000121, Chr II from 171481-171918, Verified ORF, "Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I"
>YBL026W LSM2 SGDID:S000000122, Chr II from 170623-170676,170805-171038, Verified ORF, "Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA"
>YBL027W RPL19B SGDID:S000000123, Chr II from 168423-168424,168809-169376, Verified ORF, "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Ap and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal"
>YBL028C YBL028C SGDID:S000000124, Chr II from 167838-167518, reverse complement, Verified ORF, "Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis"
>YBL029C-A YBL029C-A SGDID:S000007591, Chr II from 164772-164488, reverse complement, Uncharacterized ORF, "Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica"
>YBL029W YBL029W SGDID:S000000125, Chr II from 166134-167264, Uncharacterized ORF, "Non-essential protein of unknown function"
>YBL030C PET9 SGDID:S000000126, Chr II from 163997-163041, reverse complement, Verified ORF, "Major ADP/ATP carrier of the mitochondrial inner membrane, exchanges cytosolic ADP for mitochondrially synthesized ATP; also imports heme and ATP; phosphorylated; required for viability in many lab strains that carry a sal1 mutation"
>YBL031W SHE1 SGDID:S000000127, Chr II from 161699-162715, Verified ORF, "Mitotic spindle protein that interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure"
>YBL032W HEK2 SGDID:S000000128, Chr II from 160184-161329, Verified ORF, "RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K"
>YBL033C RIB1 SGDID:S000000129, Chr II from 159693-158656, reverse complement, Verified ORF, "GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway"
>YBL034C STU1 SGDID:S000000130, Chr II from 158389-153848, reverse complement, Verified ORF, "Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles"
>YBL035C POL12 SGDID:S000000131, Chr II from 153610-151493, reverse complement, Verified ORF, "B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation"
>YBL036C YBL036C SGDID:S000000132, Chr II from 151220-150447, reverse complement, Verified ORF, "Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS"
>YBL037W APL3 SGDID:S000000133, Chr II from 147209-150286, Verified ORF, "Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport"
>YBL038W MRPL16 SGDID:S000000134, Chr II from 146187-146885, Verified ORF, "Mitochondrial ribosomal protein of the large subunit"
>YBL039C URA7 SGDID:S000000135, Chr II from 145728-143989, reverse complement, Verified ORF, "Major CTP synthase isozyme (see also URA8), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis"
>YBL039C-A YBL039C-A SGDID:S000028814, Chr II from 145031-144948, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF URA7; identified by expression profiling and mass spectrometry"
>YBL039W-B YBL039W-B SGDID:S000028517, Chr II from 143393-143572, Uncharacterized ORF, "Putative protein of unknown function"
>YBL040C ERD2 SGDID:S000000136, Chr II from 142749-142112,142868-142847, reverse complement, Verified ORF, "HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins"
>YBL041W PRE7 SGDID:S000000137, Chr II from 141247-141972, Verified ORF, "Beta 6 subunit of the 20S proteasome"
>YBL042C FUI1 SGDID:S000000138, Chr II from 140260-138341, reverse complement, Verified ORF, "High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport"
>YBL043W ECM13 SGDID:S000000139, Chr II from 136688-137461, Verified ORF, "Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation"
>YBL044W YBL044W SGDID:S000000140, Chr II from 135998-136366, Uncharacterized ORF, "Putative protein of unknown function; YBL044W is not an essential protein"
>YBL045C COR1 SGDID:S000000141, Chr II from 135516-134143, reverse complement, Verified ORF, "Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain"
>YBL046W PSY4 SGDID:S000000142, Chr II from 132424-133749, Verified ORF, "Putative regulatory subunit of an evolutionarily conserved protein phosphatase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2"
>YBL047C EDE1 SGDID:S000000143, Chr II from 132040-127895, reverse complement, Verified ORF, "Key endocytic protein involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins"
>YBL048W RRT1 SGDID:S000000144, Chr II from 127299-127610, Dubious ORF, "Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data"
>YBL049W MOH1 SGDID:S000000145, Chr II from 126828-127244, Verified ORF, "Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for survival in stationary phase"
>YBL050W SEC17 SGDID:S000000146, Chr II from 125125-125154,125271-126119, Verified ORF, "Peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; stimulates the ATPase activity of Sec18p; has similarity to mammalian alpha-SNAP"
>YBL051C PIN4 SGDID:S000000147, Chr II from 124759-122753, reverse complement, Verified ORF, "Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage"
>YBL052C SAS3 SGDID:S000000148, Chr II from 121874-119379, reverse complement, Verified ORF, "Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal"
>YBL053W YBL053W SGDID:S000000149, Chr II from 119335-119709, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YBL054W TOD6 SGDID:S000000150, Chr II from 117589-119166, Verified ORF, "PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor, similar to Dot6p; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manne"
>YBL055C YBL055C SGDID:S000000151, Chr II from 116829-115573, reverse complement, Verified ORF, "3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases"
>YBL056W PTC3 SGDID:S000000152, Chr II from 113762-115168, Verified ORF, "Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA checkpoint inactivation"
>YBL057C PTH2 SGDID:S000000153, Chr II from 113427-112801, reverse complement, Verified ORF, "One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth"
>YBL058W SHP1 SGDID:S000000154, Chr II from 111437-112708, Verified ORF, "UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate"
>YBL059C-A CMC2 SGDID:S000007488, Chr II from 110420-110125,110539-110506, reverse complement, Verified ORF, "Protein of the mitochondrial intermembrane space with a role in respiratory chain complex assembly or maintenance; contains twin Cx9C motifs that can form coiled coil-helix-coiled-coil helix fold"
>YBL059W YBL059W SGDID:S000000155, Chr II from 110594-110879,110949-111244, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YBL060W YEL1 SGDID:S000000156, Chr II from 107932-109995, Verified ORF, "Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip"
>YBL061C SKT5 SGDID:S000000157, Chr II from 107406-105316, reverse complement, Verified ORF, "Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p; has similarity to Shc1p, which activates Chs3p during sporulation"
>YBL062W YBL062W SGDID:S000000158, Chr II from 105308-105688, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YBL063W KIP1 SGDID:S000000159, Chr II from 101886-105221, Verified ORF, "Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions"
>YBL064C PRX1 SGDID:S000000160, Chr II from 101156-100371, reverse complement, Verified ORF, "Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated"
>YBL065W YBL065W SGDID:S000000161, Chr II from 99963-100307, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene"
>YBL066C SEF1 SGDID:S000000162, Chr II from 100115-96669, reverse complement, Verified ORF, "Putative transcription factor, has homolog in Kluyveromyces lactis"
>YBL067C UBP13 SGDID:S000000163, Chr II from 95882-93639, reverse complement, Verified ORF, "Putative ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions"
>YBL068W PRS4 SGDID:S000000164, Chr II from 92414-93394, Verified ORF, "5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes"
>YBL068W-A YBL068W-A SGDID:S000028530, Chr II from 91794-92030, Dubious ORF, "Dubious open reading frame unlikely to encode a protein; identified by fungal homology and RT-PCR"
>YBL069W AST1 SGDID:S000000165, Chr II from 90741-92030, Verified ORF, "Peripheral membrane protein that interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane, possibly by influencing its incorporation into lipid rafts"
>YBL070C YBL070C SGDID:S000000166, Chr II from 90925-90605, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YBL071C YBL071C SGDID:S000000167, Chr II from 90531-90223, reverse complement, Dubious ORF, "Dubious open reading frame, predicted protein contains a peroxisomal targeting signal"
>YBL071C-B YBL071C-B SGDID:S000028597, Chr II from 89556-89458, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YBL071W-A KTI11 SGDID:S000007587, Chr II from 89978-90226, Verified ORF, "Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs"
>YBL072C RPS8A SGDID:S000000168, Chr II from 89125-88523, reverse complement, Verified ORF, "Protein component of the small (40S) ribosomal subunit; identical to Rps8Bp and has similarity to rat S8 ribosomal protein"
>YBL073W YBL073W SGDID:S000000169, Chr II from 87646-87957, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene AAR2/YBL074C"
>YBL074C AAR2 SGDID:S000000170, Chr II from 87789-86722, reverse complement, Verified ORF, "Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron"
>YBL075C SSA3 SGDID:S000000171, Chr II from 86448-84499, reverse complement, Verified ORF, "ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm"
>YBL076C ILS1 SGDID:S000000172, Chr II from 84261-81043, reverse complement, Verified ORF, "Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A"
>YBL077W YBL077W SGDID:S000000173, Chr II from 80897-81328, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C"
>YBL078C ATG8 SGDID:S000000174, Chr II from 80731-80378, reverse complement, Verified ORF, "Component of autophagosomes and Cvt vesicles; undergoes conjugation to phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation"
>YBL079W NUP170 SGDID:S000000175, Chr II from 75259-79767, Verified ORF, "Subunit of the nuclear pore complex (NPC), required for NPC localization of specific nucleoporins; involved in nuclear envelope permeability and chromosome segregation; has similar to Nup157p; essential role, with Nup157p, in NPC assembly"
>YBL080C PET112 SGDID:S000000176, Chr II from 74695-73070, reverse complement, Verified ORF, "Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog"
>YBL081W YBL081W SGDID:S000000177, Chr II from 71866-72972, Uncharacterized ORF, "Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport"
>YBL082C ALG3 SGDID:S000000178, Chr II from 71127-69751, reverse complement, Verified ORF, "Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins"
>YBL083C YBL083C SGDID:S000000179, Chr II from 70138-69713, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified ORF ALG3"
>YBL084C CDC27 SGDID:S000000180, Chr II from 69445-67169, reverse complement, Verified ORF, "Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition"
>YBL085W BOI1 SGDID:S000000181, Chr II from 63876-66818, Verified ORF, "Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain"
>YBL086C YBL086C SGDID:S000000182, Chr II from 62602-61202, reverse complement, Uncharacterized ORF, "Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery"
>YBL087C RPL23A SGDID:S000000183, Chr II from 60193-59822,60739-60698, reverse complement, Verified ORF, "Protein component of the large (60S) ribosomal subunit, identical to Rpl23Bp and has similarity to E. coli L14 and rat L23 ribosomal proteins"
>YBL088C TEL1 SGDID:S000000184, Chr II from 59382-51019, reverse complement, Verified ORF, "Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia telangiectasia (ATM) gene"
>YBL089W AVT5 SGDID:S000000185, Chr II from 49574-50953, Verified ORF, "Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters"
>YBL090W MRP21 SGDID:S000000186, Chr II from 48825-49358, Verified ORF, "Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences"
>YBL091C MAP2 SGDID:S000000187, Chr II from 48628-47363, reverse complement, Verified ORF, "Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p"
>YBL091C-A SCS22 SGDID:S000007228, Chr II from 47058-46565,47180-47147, reverse complement, Verified ORF, "Protein involved in regulation of phospholipid metabolism; homolog of Scs2p; similar to D. melanogaster inturned protein"
>YBL092W RPL32 SGDID:S000000188, Chr II from 45978-46370, Verified ORF, "Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing"
>YBL093C ROX3 SGDID:S000000189, Chr II from 44918-44256, reverse complement, Verified ORF, "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme"
>YBL094C YBL094C SGDID:S000000190, Chr II from 44097-43765, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W"
>YBL095W YBL095W SGDID:S000000191, Chr II from 43277-44089, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YBL096C YBL096C SGDID:S000000192, Chr II from 43482-43174, reverse complement, Dubious ORF, "Non-essential protein of unknown function"
>YBL097W BRN1 SGDID:S000000193, Chr II from 40831-43095, Verified ORF, "Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission"
>YBL098W BNA4 SGDID:S000000194, Chr II from 39145-40527, Verified ORF, "Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease"
>YBL099W ATP1 SGDID:S000000195, Chr II from 37053-38690, Verified ORF, "Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated"
>YBL100C YBL100C SGDID:S000000196, Chr II from 37303-36989, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the 5' end of ATP1"
>YBL100W-A YBL100W-A SGDID:S000002148, Chr II from 29935-31251, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YBL100W-B YBL100W-B SGDID:S000002149, Chr II from 29935-31227,31229-35248, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YBL100W-C YBL100W-C SGDID:S000028598, Chr II from 28427-28546, Uncharacterized ORF, "Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YBL101C ECM21 SGDID:S000000197, Chr II from 28299-24946, reverse complement, Verified ORF, "Protein involved in regulating the endocytosis of plasma membrane proteins; identified as a substrate for ubiquitination by Rsp5p and deubiquitination by Ubp2p; promoter contains several Gcn4p binding elements"
>YBL102W SFT2 SGDID:S000000198, Chr II from 24098-24745, Verified ORF, "Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5"
>YBL103C RTG3 SGDID:S000000199, Chr II from 23536-22076, reverse complement, Verified ORF, "Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways"
>YBL104C YBL104C SGDID:S000000200, Chr II from 21293-18177, reverse complement, Uncharacterized ORF, "Putative protein of unknown function, promoter contains multiple GCN4 binding sites"
>YBL105C PKC1 SGDID:S000000201, Chr II from 17696-14241, reverse complement, Verified ORF, "Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)"
>YBL106C SRO77 SGDID:S000000202, Chr II from 13879-10847, reverse complement, Verified ORF, "Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Sro7p and Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p"
>YBL107C YBL107C SGDID:S000000203, Chr II from 10551-9961, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YBL107C is not an essential gene"
>YBL107W-A YBL107W-A SGDID:S000007229, Chr II from 9268-9372, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the Ty2 LTR YBLWdelta2"
>YBL108C-A PAU9 SGDID:S000007592, Chr II from 7733-7605, reverse complement, Verified ORF, "Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions"
>YBL108W YBL108W SGDID:S000000204, Chr II from 8177-8482, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YBL109W YBL109W SGDID:S000002150, Chr II from 5790-6125, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data"
>YBL111C YBL111C SGDID:S000002151, Chr II from 4116-2907,5009-4216, reverse complement, Uncharacterized ORF, "Helicase-like protein encoded within the telomeric Y' element"
>YBL112C YBL112C SGDID:S000002152, Chr II from 2899-2582, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; YBL112C is contained within TEL02L"
>YBL113C YBL113C SGDID:S000002153, Chr II from 2658-280, reverse complement, Uncharacterized ORF, "Helicase-like protein encoded within the telomeric Y' element"
>YBL113W-A YBL113W-A SGDID:S000028599, Chr II from 646-1128, Dubious ORF, "Dubious open reading frame unlikely to encode a protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YBR001C NTH2 SGDID:S000000205, Chr II from 241283-238941, reverse complement, Verified ORF, "Putative neutral trehalase, required for thermotolerance and may mediate resistance to other cellular stresses"
>YBR002C RER2 SGDID:S000000206, Chr II from 242568-241708, reverse complement, Verified ORF, "Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting"
>YBR003W COQ1 SGDID:S000000207, Chr II from 242809-244230, Verified ORF, "Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis"
>YBR004C GPI18 SGDID:S000000208, Chr II from 245667-244366, reverse complement, Verified ORF, "Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria"
>YBR005W RCR1 SGDID:S000000209, Chr II from 245906-246547, Verified ORF, "Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane"
>YBR006W UGA2 SGDID:S000000210, Chr II from 247010-248503, Verified ORF, "Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm"
>YBR007C DSF2 SGDID:S000000211, Chr II from 251016-248806, reverse complement, Uncharacterized ORF, "Deletion suppressor of mpt5 mutation"
>YBR008C FLR1 SGDID:S000000212, Chr II from 254209-252563, reverse complement, Verified ORF, "Plasma membrane multidrug transporter of the major facilitator superfamily, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin"
>YBR009C HHF1 SGDID:S000000213, Chr II from 255684-255373, reverse complement, Verified ORF, "Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity"
>YBR010W HHT1 SGDID:S000000214, Chr II from 256331-256741, Verified ORF, "Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation"
>YBR011C IPP1 SGDID:S000000215, Chr II from 257975-257112, reverse complement, Verified ORF, "Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase"
>YBR012C YBR012C SGDID:S000000216, Chr II from 259566-259147, reverse complement, Dubious ORF, "Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p"
>YBR012W-A YBR012W-A SGDID:S000002154, Chr II from 259869-261191, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YBR012W-B YBR012W-B SGDID:S000002155, Chr II from 259869-261173,261175-265140, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YBR013C YBR013C SGDID:S000000217, Chr II from 265881-265492, reverse complement, Uncharacterized ORF, "Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein"
>YBR014C GRX7 SGDID:S000000218, Chr II from 267336-266725, reverse complement, Verified ORF, "Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; functional overlap with GRX6"
>YBR015C MNN2 SGDID:S000000219, Chr II from 269503-267710, reverse complement, Verified ORF, "Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment"
>YBR016W YBR016W SGDID:S000000220, Chr II from 270247-270633, Verified ORF, "Tail-anchored plasma membrane protein containing a conserved CYSTM module; predicted to be palmitoylated; has similarity to hydrophilins, which are involved in the adaptive response to hyperosmotic conditions"
>YBR017C KAP104 SGDID:S000000221, Chr II from 273703-270947, reverse complement, Verified ORF, "Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis"
>YBR018C GAL7 SGDID:S000000222, Chr II from 275527-274427, reverse complement, Verified ORF, "Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism"
>YBR019C GAL10 SGDID:S000000223, Chr II from 278352-276253, reverse complement, Verified ORF, "UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers"
>YBR020W GAL1 SGDID:S000000224, Chr II from 279021-280607, Verified ORF, "Galactokinase, phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p"
>YBR021W FUR4 SGDID:S000000225, Chr II from 281443-283344, Verified ORF, "Uracil permease, localized to the plasma membrane; expression is tightly regulated by uracil levels and environmental cues"
>YBR022W POA1 SGDID:S000000226, Chr II from 283738-284271, Verified ORF, "Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing"
>YBR023C CHS3 SGDID:S000000227, Chr II from 287925-284428, reverse complement, Verified ORF, "Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan"
>YBR024W SCO2 SGDID:S000000228, Chr II from 289445-290350, Verified ORF, "Protein anchored to the mitochondrial inner membrane, similar to Sco1p and may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p"
>YBR025C OLA1 SGDID:S000000229, Chr II from 291865-290681, reverse complement, Verified ORF, "P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein levels are induced by hydrogen peroxide"
>YBR026C ETR1 SGDID:S000000230, Chr II from 294019-292877, reverse complement, Verified ORF, "2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis"
>YBR027C YBR027C SGDID:S000000231, Chr II from 294356-294024, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YBR028C YBR028C SGDID:S000000232, Chr II from 296002-294425, reverse complement, Uncharacterized ORF, "Putative protein kinase, possible substrate of cAMP-dependent protein kinase (PKA)"
>YBR029C CDS1 SGDID:S000000233, Chr II from 297742-296369, reverse complement, Verified ORF, "Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids"
>YBR030W RKM3 SGDID:S000000234, Chr II from 298292-299950, Verified ORF, "Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein"
>YBR031W RPL4A SGDID:S000000235, Chr II from 300166-301254, Verified ORF, "N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Bp and has similarity to E. coli L4 and rat L4 ribosomal proteins"
>YBR032W YBR032W SGDID:S000000236, Chr II from 301519-301821, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data"
>YBR033W EDS1 SGDID:S000000237, Chr II from 301944-304703, Uncharacterized ORF, "Putative zinc cluster protein; YBR033W is not an essential gene"
>YBR034C HMT1 SGDID:S000000238, Chr II from 305976-304930, reverse complement, Verified ORF, "Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p"
>YBR035C PDX3 SGDID:S000000239, Chr II from 306955-306269, reverse complement, Verified ORF, "Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism"
>YBR036C CSG2 SGDID:S000000240, Chr II from 310313-309081, reverse complement, Verified ORF, "Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations"
>YBR037C SCO1 SGDID:S000000241, Chr II from 311452-310565, reverse complement, Verified ORF, "Copper-binding protein of the mitochondrial inner membrane, required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; has similarity to thioredoxins"
>YBR038W CHS2 SGDID:S000000242, Chr II from 311898-314789, Verified ORF, "Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis"
>YBR039W ATP3 SGDID:S000000243, Chr II from 315575-316510, Verified ORF, "Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis"
>YBR040W FIG1 SGDID:S000000244, Chr II from 316968-317864, Verified ORF, "Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating"
>YBR041W FAT1 SGDID:S000000245, Chr II from 318266-320275, Verified ORF, "Very long chain fatty acyl-CoA synthetase and long chain fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids"
>YBR042C CST26 SGDID:S000000246, Chr II from 321609-320416, reverse complement, Verified ORF, "Protein required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed"
>YBR043C QDR3 SGDID:S000000247, Chr II from 323945-321876, reverse complement, Verified ORF, "Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin"
>YBR044C TCM62 SGDID:S000000248, Chr II from 326059-324341, reverse complement, Verified ORF, "Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone"
>YBR045C GIP1 SGDID:S000000249, Chr II from 330092-328173, reverse complement, Verified ORF, "Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p"
>YBR046C ZTA1 SGDID:S000000250, Chr II from 331511-330507, reverse complement, Verified ORF, "NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin"
>YBR047W FMP23 SGDID:S000000251, Chr II from 331833-332360, Uncharacterized ORF, "Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YBR048W RPS11B SGDID:S000000252, Chr II from 332831-332875,333387-333812, Verified ORF, "Protein component of the small (40S) ribosomal subunit; identical to Rps11Ap and has similarity to E. coli S17 and rat S11 ribosomal proteins"
>YBR049C REB1 SGDID:S000000253, Chr II from 336818-334386, reverse complement, Verified ORF, "RNA polymerase I enhancer binding protein; DNA binding protein which binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription"
>YBR050C REG2 SGDID:S000000254, Chr II from 338199-337183, reverse complement, Verified ORF, "Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease"
>YBR051W YBR051W SGDID:S000000255, Chr II from 337988-338338, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase"
>YBR052C RFS1 SGDID:S000000256, Chr II from 339352-338720, reverse complement, Verified ORF, "Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern"
>YBR053C YBR053C SGDID:S000000257, Chr II from 340751-339675, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; induced by cell wall perturbation"
>YBR054W YRO2 SGDID:S000000258, Chr II from 343101-344135, Verified ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p"
>YBR055C PRP6 SGDID:S000000259, Chr II from 347301-344602, reverse complement, Verified ORF, "Splicing factor, component of the U4/U6-U5 snRNP complex"
>YBR056C-B YBR056C-B SGDID:S000087087, Chr II from 351451-351293, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the dubious ORF YBR056W-A"
>YBR056W YBR056W SGDID:S000000260, Chr II from 347879-349384, Uncharacterized ORF, "Putative cytoplasmic protein of unknown function"
>YBR056W-A YBR056W-A SGDID:S000028736, Chr II from 351255-351455, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR056C-B"
>YBR057C MUM2 SGDID:S000000261, Chr II from 353293-352193, reverse complement, Verified ORF, "Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex"
>YBR058C UBP14 SGDID:S000000262, Chr II from 356017-353672, reverse complement, Verified ORF, "Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T"
>YBR058C-A TSC3 SGDID:S000007521, Chr II from 356566-356324, reverse complement, Verified ORF, "Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis"
>YBR059C AKL1 SGDID:S000000263, Chr II from 360187-356861, reverse complement, Verified ORF, "Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization"
>YBR060C ORC2 SGDID:S000000264, Chr II from 362514-360652, reverse complement, Verified ORF, "Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p"
>YBR061C TRM7 SGDID:S000000265, Chr II from 365719-364787, reverse complement, Verified ORF, "2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop"
>YBR062C YBR062C SGDID:S000000266, Chr II from 366502-365976,366600-366585, reverse complement, Uncharacterized ORF, "Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway."
>YBR063C YBR063C SGDID:S000000267, Chr II from 368184-366970, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; YBR063C is not an essential gene"
>YBR064W YBR064W SGDID:S000000268, Chr II from 367763-368191, Dubious ORF, "Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YBR063C"
>YBR065C ECM2 SGDID:S000000269, Chr II from 369678-368584, reverse complement, Verified ORF, "Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p"
>YBR066C NRG2 SGDID:S000000270, Chr II from 370699-370037, reverse complement, Verified ORF, "Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth; has similarity to Nrg1p"
>YBR067C TIP1 SGDID:S000000271, Chr II from 372735-372103, reverse complement, Verified ORF, "Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins"
>YBR068C BAP2 SGDID:S000000272, Chr II from 375690-373861, reverse complement, Verified ORF, "High-affinity leucine permease, functions as a branched-chain amino acid permease involved in the uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains"
>YBR069C TAT1 SGDID:S000000273, Chr II from 378433-376574, reverse complement, Verified ORF, "Amino acid transport protein for valine, leucine, isoleucine, and tyrosine, low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance"
>YBR070C ALG14 SGDID:S000000274, Chr II from 379934-379221, reverse complement, Verified ORF, "Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases"
>YBR071W YBR071W SGDID:S000000275, Chr II from 380411-381046, Uncharacterized ORF, "Putative protein of unknown function; (GFP)-fusion and epitope-tagged proteins localize to the cytoplasm; mRNA expression may be regulated by the cell cycle and/or cell wall stress"
>YBR072C-A YBR072C-A SGDID:S000028532, Chr II from 383021-382860, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by fungal homology and RT-PCR"
>YBR072W HSP26 SGDID:S000000276, Chr II from 382030-382674, Verified ORF, "Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires heat-induced conformational change; also has mRNA binding activity"
>YBR073W RDH54 SGDID:S000000277, Chr II from 383112-385988, Verified ORF, "DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference"
>YBR074W YBR074W SGDID:S000000278, Chr II from 386286-389216, Uncharacterized ORF, "Putative metalloprotease"
>YBR076C-A YBR076C-A SGDID:S000028533, Chr II from 391617-391351, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene ECM8; identified by fungal homology and RT-PCR"
>YBR076W ECM8 SGDID:S000000280, Chr II from 390227-391291, Verified ORF, "Non-essential protein of unknown function"
>YBR077C SLM4 SGDID:S000000281, Chr II from 392293-391805, reverse complement, Verified ORF, "Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4"
>YBR078W ECM33 SGDID:S000000282, Chr II from 393123-393180,393511-394742, Verified ORF, "GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p"
>YBR079C RPG1 SGDID:S000000283, Chr II from 398277-395383, reverse complement, Verified ORF, "eIF3a subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates binding of mRNA and tRNA(i)Met to ribosomes; involved in translation reinitiation"
>YBR080C SEC18 SGDID:S000000284, Chr II from 400890-398614, reverse complement, Verified ORF, "ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian NSF"
>YBR081C SPT7 SGDID:S000000285, Chr II from 405251-401253, reverse complement, Verified ORF, "Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex"
>YBR082C UBC4 SGDID:S000000286, Chr II from 407027-406628,407169-407123, reverse complement, Verified ORF, "Ubiquitin-conjugating enzyme (E2), mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response"
>YBR083W TEC1 SGDID:S000000287, Chr II from 409169-410629, Verified ORF, "Transcription factor required for full Ty1 expression, Ty1-mediated gene activation, and haploid invasive and diploid pseudohyphal growth; TEA/ATTS DNA-binding domain family member"
>YBR084C-A RPL19A SGDID:S000002156, Chr II from 414753-414186,415261-415260, reverse complement, Verified ORF, "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Bp and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal"
>YBR084W MIS1 SGDID:S000000288, Chr II from 411054-413981, Verified ORF, "Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase"
>YBR085C-A YBR085C-A SGDID:S000007522, Chr II from 419164-418907, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus"
>YBR085W AAC3 SGDID:S000000289, Chr II from 415983-416906, Verified ORF, "Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Pet9p and Aac1p; has roles in maintenance of viability and in respiration"
>YBR086C IST2 SGDID:S000000290, Chr II from 423041-420201, reverse complement, Verified ORF, "Plasma membrane protein that may be involved in osmotolerance, localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process"
>YBR087W RFC5 SGDID:S000000291, Chr II from 423765-424829, Verified ORF, "Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon"
>YBR088C POL30 SGDID:S000000292, Chr II from 425766-424990, reverse complement, Verified ORF, "Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair"
>YBR089C-A NHP6B SGDID:S000002157, Chr II from 426489-426190, reverse complement, Verified ORF, "High-mobility group (HMG) protein that binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2"
>YBR089W YBR089W SGDID:S000000293, Chr II from 425183-425782, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30"
>YBR090C YBR090C SGDID:S000000294, Chr II from 426516-426333,427058-426874, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus"
>YBR091C TIM12 SGDID:S000000295, Chr II from 427484-427155, reverse complement, Verified ORF, "Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins"
>YBR092C PHO3 SGDID:S000000296, Chr II from 429101-427698, reverse complement, Verified ORF, "Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin"
>YBR093C PHO5 SGDID:S000000297, Chr II from 430951-429548, reverse complement, Verified ORF, "Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2"
>YBR094W PBY1 SGDID:S000000298, Chr II from 432036-434297, Verified ORF, "Putative tubulin tyrosine ligase associated with P-bodies"
>YBR095C RXT2 SGDID:S000000299, Chr II from 435698-434406, reverse complement, Verified ORF, "Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth"
>YBR096W YBR096W SGDID:S000000300, Chr II from 436021-436713, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER"
>YBR097W VPS15 SGDID:S000000301, Chr II from 436951-441315, Verified ORF, "Myristoylated serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p"
>YBR098W MMS4 SGDID:S000000302, Chr II from 441515-443590, Verified ORF, "Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination"
>YBR099C YBR099C SGDID:S000000303, Chr II from 443307-442924, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4"
>YBR101C FES1 SGDID:S000000305, Chr II from 444693-443821, reverse complement, Verified ORF, "Hsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum"
>YBR102C EXO84 SGDID:S000000306, Chr II from 447323-445062, reverse complement, Verified ORF, "Essential protein with dual roles in spliceosome assembly and exocytosis; the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p) mediates polarized targeting of secretory vesicles to active sites of exocytosis"
>YBR103C-A YBR103C-A SGDID:S000007593, Chr II from 449463-449320, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; identified by homology to related yeast"
>YBR103W SIF2 SGDID:S000000307, Chr II from 447709-449316, Verified ORF, "WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus"
>YBR104W YMC2 SGDID:S000000308, Chr II from 449667-450656, Verified ORF, "Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p"
>YBR105C VID24 SGDID:S000000309, Chr II from 451969-450881, reverse complement, Verified ORF, "Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase"
>YBR106W PHO88 SGDID:S000000310, Chr II from 452658-453224, Verified ORF, "Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations"
>YBR107C IML3 SGDID:S000000311, Chr II from 454530-453793, reverse complement, Verified ORF, "Protein with a role in kinetochore function, localizes to the outer kinetochore in a Ctf19p-dependent manner, interacts with Chl4p and Ctf19p"
>YBR108W AIM3 SGDID:S000000312, Chr II from 454822-457665, Verified ORF, "Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss"
>YBR109C CMD1 SGDID:S000000313, Chr II from 458362-457919, reverse complement, Verified ORF, "Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin"
>YBR109W-A YBR109W-A SGDID:S000028737, Chr II from 458608-458832, Dubious ORF, "Putative protein of unknown function; questionable ORF from MIPS"
>YBR110W ALG1 SGDID:S000000314, Chr II from 458872-460221, Verified ORF, "Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog"
>YBR111C YSA1 SGDID:S000000315, Chr II from 461873-461178, reverse complement, Verified ORF, "Nudix hydrolase family member with ADP-ribose pyrophosphatase activity; shown to metabolize O-acetyl-ADP-ribose to AMP and acetylated ribose 5'-phosphate"
>YBR111W-A SUS1 SGDID:S000028510, Chr II from 462139-462209,462290-462429,462500-462579, Verified ORF, "Protein involved in mRNA export coupled transcription activation and elongation; component of both the SAGA histone acetylase complex and TREX-2, and interacts with RNAPII"
>YBR112C CYC8 SGDID:S000000316, Chr II from 465770-462870, reverse complement, Verified ORF, "General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; can form the prion [OCT+]"
>YBR113W YBR113W SGDID:S000000317, Chr II from 465566-466048, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8"
>YBR114W RAD16 SGDID:S000000318, Chr II from 467248-469620, Verified ORF, "Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex"
>YBR115C LYS2 SGDID:S000000319, Chr II from 473926-469748, reverse complement, Verified ORF, "Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p"
>YBR116C YBR116C SGDID:S000000320, Chr II from 474726-474199, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2"
>YBR117C TKL2 SGDID:S000000321, Chr II from 476437-474392, reverse complement, Verified ORF, "Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids"
>YBR118W TEF2 SGDID:S000000322, Chr II from 477671-479047, Verified ORF, "Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus"
>YBR119W MUD1 SGDID:S000000323, Chr II from 479338-479345,479435-480323, Verified ORF, "U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing"
>YBR120C CBP6 SGDID:S000000324, Chr II from 480923-480435, reverse complement, Verified ORF, "Mitochondrial translational activator of the COB mRNA; phosphorylated"
>YBR121C GRS1 SGDID:S000000325, Chr II from 483367-481364, reverse complement, Verified ORF, "Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation"
>YBR121C-A YBR121C-A SGDID:S000028815, Chr II from 482484-482326, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely contianed within the verified gene GRS1; identified by expression profiling and mass spectrometry"
>YBR122C MRPL36 SGDID:S000000326, Chr II from 484503-483970, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the large subunit; overproduction suppresses mutations in the COX2 leader peptide-encoding region"
>YBR123C TFC1 SGDID:S000000327, Chr II from 486691-484742, reverse complement, Verified ORF, "One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63"
>YBR124W YBR124W SGDID:S000000328, Chr II from 486507-486866, Dubious ORF, "Putative protein of unknown function"
>YBR125C PTC4 SGDID:S000000329, Chr II from 488380-487199, reverse complement, Verified ORF, "Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity"
>YBR126C TPS1 SGDID:S000000330, Chr II from 490392-488905, reverse complement, Verified ORF, "Synthase subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway"
>YBR126W-A YBR126W-A SGDID:S000028600, Chr II from 490850-491056, Dubious ORF, "Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR126W-B; identified by gene-trapping, microarray analysis, and genome-wide homology searches"
>YBR126W-B YBR126W-B SGDID:S000028738, Chr II from 490927-491070, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR126W-A; Identified by SAGE"
>YBR127C VMA2 SGDID:S000000331, Chr II from 492822-491269, reverse complement, Verified ORF, "Subunit B of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; contains nucleotide binding sites; also detected in the cytoplasm"
>YBR128C ATG14 SGDID:S000000332, Chr II from 494115-493081, reverse complement, Verified ORF, "Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I (with Vps34/15/30p); Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; homolog of human Barkor"
>YBR129C OPY1 SGDID:S000000333, Chr II from 495339-494353, reverse complement, Verified ORF, "Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YBR130C SHE3 SGDID:S000000334, Chr II from 496869-495592, reverse complement, Verified ORF, "Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance"
>YBR131C-A YBR131C-A SGDID:S000028601, Chr II from 497739-497650, reverse complement, Dubious ORF, "Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR131W. Identified by gene-trapping, microarray analysis, and genome-wide homology searches"
>YBR131W CCZ1 SGDID:S000000335, Chr II from 497163-499277, Verified ORF, "Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway"
>YBR132C AGP2 SGDID:S000000336, Chr II from 501442-499652, reverse complement, Verified ORF, "High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease"
>YBR133C HSL7 SGDID:S000000337, Chr II from 504287-501804, reverse complement, Verified ORF, "Protein arginine N-methyltransferase that exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p"
>YBR134W YBR134W SGDID:S000000338, Chr II from 504243-504644, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YBR135W CKS1 SGDID:S000000339, Chr II from 504854-505306, Verified ORF, "Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters"
>YBR136W MEC1 SGDID:S000000340, Chr II from 505668-512774, Verified ORF, "Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination"
>YBR137W YBR137W SGDID:S000000341, Chr II from 513044-513583, Verified ORF, "Protein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); also interacts with Sgt2p; YBR137W is not an essential gene"
>YBR138C YBR138C SGDID:S000000342, Chr II from 515336-513762, reverse complement, Uncharacterized ORF, "Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene"
>YBR139W YBR139W SGDID:S000000343, Chr II from 515664-517190, Verified ORF, "Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner"
>YBR140C IRA1 SGDID:S000000344, Chr II from 526628-517350, reverse complement, Verified ORF, "GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase"
>YBR141C YBR141C SGDID:S000000345, Chr II from 528038-527025, reverse complement, Uncharacterized ORF, "Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene"
>YBR141W-A YBR141W-A SGDID:S000028602, Chr II from 527167-527262, Dubious ORF, "Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YBR141C; identified by gene-trapping, microarray analysis, and genome-wide homology searching"
>YBR142W MAK5 SGDID:S000000346, Chr II from 528317-530638, Verified ORF, "Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits"
>YBR143C SUP45 SGDID:S000000347, Chr II from 532182-530869, reverse complement, Verified ORF, "Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin"
>YBR144C YBR144C SGDID:S000000348, Chr II from 533549-533235, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene"
>YBR145W ADH5 SGDID:S000000349, Chr II from 533762-534817, Verified ORF, "Alcohol dehydrogenase isoenzyme V; involved in ethanol production"
>YBR146W MRPS9 SGDID:S000000350, Chr II from 535260-536096, Verified ORF, "Mitochondrial ribosomal protein of the small subunit"
>YBR147W RTC2 SGDID:S000000351, Chr II from 536575-537465, Verified ORF, "Protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; detected in highly purified mitochondria; null mutant suppresses cdc13-1; similar to a G-protein coupled receptor from S. pombe"
>YBR148W YSW1 SGDID:S000000352, Chr II from 537876-539705, Verified ORF, "Protein required for normal prospore membrane formation; interacts with Gip1p, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase; expressed specifically in spores and localizes to the prospore membrane"
>YBR149W ARA1 SGDID:S000000353, Chr II from 539987-541021, Verified ORF, "NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product"
>YBR150C TBS1 SGDID:S000000354, Chr II from 544493-541209, reverse complement, Verified ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YBR151W APD1 SGDID:S000000355, Chr II from 545028-545978, Verified ORF, "Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus"
>YBR152W SPP381 SGDID:S000000356, Chr II from 546376-547251, Verified ORF, "mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p"
>YBR153W RIB7 SGDID:S000000357, Chr II from 547460-548194, Verified ORF, "Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway"
>YBR154C RPB5 SGDID:S000000358, Chr II from 549009-548362, reverse complement, Verified ORF, "RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation"
>YBR155W CNS1 SGDID:S000000359, Chr II from 549771-550928, Verified ORF, "TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion"
>YBR156C SLI15 SGDID:S000000360, Chr II from 553200-551104, reverse complement, Verified ORF, "Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly"
>YBR157C ICS2 SGDID:S000000361, Chr II from 554310-553543, reverse complement, Verified ORF, "Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization"
>YBR158W AMN1 SGDID:S000000362, Chr II from 556549-558198, Verified ORF, "Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)"
>YBR159W IFA38 SGDID:S000000363, Chr II from 558685-559728, Verified ORF, "Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides"
>YBR160W CDC28 SGDID:S000000364, Chr II from 560078-560974, Verified ORF, "Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates"
>YBR161W CSH1 SGDID:S000000365, Chr II from 561634-562764, Verified ORF, "Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p"
>YBR162C TOS1 SGDID:S000000366, Chr II from 564570-563203, reverse complement, Verified ORF, "Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C"
>YBR162W-A YSY6 SGDID:S000002158, Chr II from 565231-565428, Verified ORF, "Protein whose expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion"
>YBR163W EXO5 SGDID:S000000367, Chr II from 565723-567480, Verified ORF, "Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2"
>YBR164C ARL1 SGDID:S000000368, Chr II from 568426-567875, reverse complement, Verified ORF, "Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor"
>YBR165W UBS1 SGDID:S000000369, Chr II from 568852-569685, Verified ORF, "Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity"
>YBR166C TYR1 SGDID:S000000370, Chr II from 571200-569842, reverse complement, Verified ORF, "Prephenate dehydrogenase involved in tyrosine biosynthesis, expression is dependent on phenylalanine levels"
>YBR167C POP7 SGDID:S000000371, Chr II from 571890-571468, reverse complement, Verified ORF, "Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends"
>YBR168W PEX32 SGDID:S000000372, Chr II from 572371-573612, Verified ORF, "Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p"
>YBR169C SSE2 SGDID:S000000373, Chr II from 575996-573915, reverse complement, Verified ORF, "Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; highly homologous to the heat shock protein Sse1p"
>YBR170C NPL4 SGDID:S000000374, Chr II from 578086-576344, reverse complement, Verified ORF, "Endoplasmic reticulum and nuclear membrane protein, forms a complex with Cdc48p and Ufd1p that recognizes ubiquitinated proteins in the endoplasmic reticulum and delivers them to the proteasome for degradation"
>YBR171W SEC66 SGDID:S000000375, Chr II from 578364-578984, Verified ORF, "Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER"
>YBR172C SMY2 SGDID:S000000376, Chr II from 581372-579150, reverse complement, Verified ORF, "Protein of unknown function involved in COPII vesicle formation; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; has similarity to S. pombe Mpd2"
>YBR173C UMP1 SGDID:S000000377, Chr II from 582172-581726, reverse complement, Verified ORF, "Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly"
>YBR174C YBR174C SGDID:S000000378, Chr II from 582652-582338, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective"
>YBR175W SWD3 SGDID:S000000379, Chr II from 582408-583355, Verified ORF, "Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5"
>YBR176W ECM31 SGDID:S000000380, Chr II from 583720-584658, Verified ORF, "Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate"
>YBR177C EHT1 SGDID:S000000381, Chr II from 586162-584807, reverse complement, Verified ORF, "Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane"
>YBR178W YBR178W SGDID:S000000382, Chr II from 586071-586445, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C"
>YBR179C FZO1 SGDID:S000000383, Chr II from 589114-586547, reverse complement, Verified ORF, "Mitofusin, mitochondrial integral membrane protein involved in mitochondrial fusion and mitochondrial genome maintenance; contains N-terminal GTPase domain; targeted for destruction by cytosolic components of the ubiquitin-proteasome system"
>YBR180W DTR1 SGDID:S000000384, Chr II from 589741-591459, Verified ORF, "Putative dityrosine transporter, required for spore wall synthesis; expressed during sporulation; member of the major facilitator superfamily (DHA1 family) of multidrug resistance transporters"
>YBR181C RPS6B SGDID:S000000385, Chr II from 592416-591712,592774-592769, reverse complement, Verified ORF, "Protein component of the small (40S) ribosomal subunit; identical to Rps6Ap and has similarity to rat S6 ribosomal protein"
>YBR182C SMP1 SGDID:S000000386, Chr II from 594864-593506, reverse complement, Verified ORF, "Putative transcription factor involved in regulating the response to osmotic stress; member of the MADS-box family of transcription factors"
>YBR182C-A YBR182C-A SGDID:S000028603, Chr II from 595555-595361, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YBR183W YPC1 SGDID:S000000387, Chr II from 596115-597065, Verified ORF, "Alkaline ceramidase that also has reverse (CoA-independent) ceramide synthase activity, catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance"
>YBR184W YBR184W SGDID:S000000388, Chr II from 597363-598934, Uncharacterized ORF, "Putative protein of unknown function; YBR184W is not an essential gene"
>YBR185C MBA1 SGDID:S000000389, Chr II from 599959-599123, reverse complement, Verified ORF, "Membrane-associated mitochondrial ribosome receptor; involved in assembly of mitochondrial respiratory complexes; may act as a receptor for proteins destined for export from the mitochondrial matrix to the inner membrane"
>YBR186W PCH2 SGDID:S000000390, Chr II from 600553-602103,602217-602360, Verified ORF, "Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA"
>YBR187W GDT1 SGDID:S000000391, Chr II from 602634-603476, Uncharacterized ORF, "Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis"
>YBR188C NTC20 SGDID:S000000392, Chr II from 604107-603685, reverse complement, Verified ORF, "Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs"
>YBR189W RPS9B SGDID:S000000393, Chr II from 604508-604514,604928-605508, Verified ORF, "Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Ap and has similarity to E. coli S4 and rat S9 ribosomal proteins"
>YBR190W YBR190W SGDID:S000000394, Chr II from 605966-606277, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W"
>YBR191W RPL21A SGDID:S000000395, Chr II from 606270-606280,606669-607140, Verified ORF, "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Bp and has similarity to rat L21 ribosomal protein"
>YBR191W-A YBR191W-A SGDID:S000007594, Chr II from 607149-607223, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YBR192W RIM2 SGDID:S000000396, Chr II from 607652-608785, Verified ORF, "Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family"
>YBR193C MED8 SGDID:S000000397, Chr II from 609753-609082, reverse complement, Verified ORF, "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation"
>YBR194W AIM4 SGDID:S000000398, Chr II from 610038-610409, Verified ORF, "Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress"
>YBR195C MSI1 SGDID:S000000399, Chr II from 611882-610614, reverse complement, Verified ORF, "Subunit of chromatin assembly factor I (CAF-1), negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase; localizes to the nucleus and cytoplasm; homologous to human retinoblastoma binding proteins RbAp48 and RbAp46"
>YBR196C PGI1 SGDID:S000000400, Chr II from 613900-612236, reverse complement, Verified ORF, "Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation"
>YBR196C-A YBR196C-A SGDID:S000028534, Chr II from 614173-614024, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by fungal homology and RT-PCR"
>YBR196C-B YBR196C-B SGDID:S000028816, Chr II from 614630-614526, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by expression profiling and mass spectrometry"
>YBR197C YBR197C SGDID:S000000401, Chr II from 615856-615203, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene"
>YBR198C TAF5 SGDID:S000000402, Chr II from 618523-616127, reverse complement, Verified ORF, "Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification"
>YBR199W KTR4 SGDID:S000000403, Chr II from 618909-620303, Verified ORF, "Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family"
>YBR200W BEM1 SGDID:S000000404, Chr II from 620872-622527, Verified ORF, "Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p"
>YBR200W-A YBR200W-A SGDID:S000028535, Chr II from 622983-623147, Uncharacterized ORF, "Putative protein of unknown function; identified by fungal homology and RT-PCR"
>YBR201C-A YBR201C-A SGDID:S000087085, Chr II from 624696-624493, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YBR201W DER1 SGDID:S000000405, Chr II from 623576-624211, Verified ORF, "Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p"
>YBR202W MCM7 SGDID:S000000406, Chr II from 625772-628309, Verified ORF, "Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase"
>YBR203W COS111 SGDID:S000000407, Chr II from 629168-631942, Verified ORF, "Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YBR204C YBR204C SGDID:S000000408, Chr II from 633381-632254, reverse complement, Verified ORF, "Serine hydrolase; YBR204C is not an essential gene"
>YBR205W KTR3 SGDID:S000000409, Chr II from 633622-634836, Verified ORF, "Putative alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family"
>YBR206W YBR206W SGDID:S000000410, Chr II from 634601-634924, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3"
>YBR207W FTH1 SGDID:S000000411, Chr II from 635146-636543, Verified ORF, "Putative high affinity iron transporter involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis"
>YBR208C DUR1,2 SGDID:S000000412, Chr II from 642210-636703, reverse complement, Verified ORF, "Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation"
>YBR209W YBR209W SGDID:S000000413, Chr II from 642583-642900, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR209W is not an essential gene"
>YBR210W ERV15 SGDID:S000000414, Chr II from 645550-645978, Verified ORF, "Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p"
>YBR211C AME1 SGDID:S000000415, Chr II from 647132-646158, reverse complement, Verified ORF, "Essential kinetochore protein associated with microtubules and spindle pole bodies; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance"
>YBR212W NGR1 SGDID:S000000416, Chr II from 647886-649904, Verified ORF, "RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; expressed in stationary phase"
>YBR213W MET8 SGDID:S000000417, Chr II from 650368-651192, Verified ORF, "Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis"
>YBR214W SDS24 SGDID:S000000418, Chr II from 651415-652998, Verified ORF, "One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; may play an indirect role in fluid-phase endocytosis"
>YBR215W HPC2 SGDID:S000000419, Chr II from 653356-653368,653453-655317, Verified ORF, "Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes"
>YBR216C YBP1 SGDID:S000000420, Chr II from 657600-655576, reverse complement, Verified ORF, "Protein required for oxidation of specific cysteine residues of the transcription factor Yap1p, resulting in the nuclear localization of Yap1p in response to stress"
>YBR217W ATG12 SGDID:S000000421, Chr II from 657832-658392, Verified ORF, "Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation"
>YBR218C PYC2 SGDID:S000000422, Chr II from 662249-658707, reverse complement, Verified ORF, "Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis"
>YBR219C YBR219C SGDID:S000000423, Chr II from 662581-662499,663303-663003, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; YBR219C is not an essential gene"
>YBR220C YBR220C SGDID:S000000424, Chr II from 664677-662995, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; YBR220C is not an essential gene"
>YBR221C PDB1 SGDID:S000000425, Chr II from 666253-665153, reverse complement, Verified ORF, "E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria"
>YBR221W-A YBR221W-A SGDID:S000028817, Chr II from 666538-666642, Uncharacterized ORF, "Putative protein of unknown function; identified by expression profiling and mass spectrometry"
>YBR222C PCS60 SGDID:S000000426, Chr II from 668351-666720, reverse complement, Verified ORF, "Peroxisomal protein that binds AMP and mRNA, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase"
>YBR223C TDP1 SGDID:S000000427, Chr II from 670297-668663, reverse complement, Verified ORF, "Tyrosyl-DNA Phosphodiesterase I, hydrolyzes 3' and 5'-phosphotyrosyl bonds, involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI"
>YBR223W-A YBR223W-A SGDID:S000028604, Chr II from 668721-668840, Dubious ORF, "Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps YBR223C; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YBR224W YBR224W SGDID:S000000428, Chr II from 670125-670640, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1"
>YBR225W YBR225W SGDID:S000000429, Chr II from 670627-673329, Uncharacterized ORF, "Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components"
>YBR226C YBR226C SGDID:S000000430, Chr II from 673565-673155, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YBR225W"
>YBR227C MCX1 SGDID:S000000431, Chr II from 675134-673572, reverse complement, Verified ORF, "Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins"
>YBR228W SLX1 SGDID:S000000432, Chr II from 675313-676227, Verified ORF, "Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p"
>YBR229C ROT2 SGDID:S000000433, Chr II from 679221-676357, reverse complement, Verified ORF, "Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations"
>YBR230C OM14 SGDID:S000000434, Chr II from 679942-679549,680050-680040, reverse complement, Verified ORF, "Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron"
>YBR230W-A YBR230W-A SGDID:S000029722, Chr II from 680362-680562, Uncharacterized ORF, "Putative protein of unknown function"
>YBR231C SWC5 SGDID:S000000435, Chr II from 683090-682179, reverse complement, Verified ORF, "Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A"
>YBR232C YBR232C SGDID:S000000436, Chr II from 683732-683373, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YBR233W PBP2 SGDID:S000000437, Chr II from 683428-684669, Verified ORF, "RNA binding protein with similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length"
>YBR233W-A DAD3 SGDID:S000007595, Chr II from 684977-685261, Verified ORF, "Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis"
>YBR234C ARC40 SGDID:S000000438, Chr II from 686592-685438, reverse complement, Verified ORF, "Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches"
>YBR235W YBR235W SGDID:S000000439, Chr II from 686901-690263, Uncharacterized ORF, "Putative ion transporter, similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family; YBR235W is not an essential gene"
>YBR236C ABD1 SGDID:S000000440, Chr II from 691693-690383, reverse complement, Verified ORF, "Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA"
>YBR237W PRP5 SGDID:S000000441, Chr II from 691969-694518, Verified ORF, "RNA helicase in the DEAD-box family, necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA"
>YBR238C YBR238C SGDID:S000000442, Chr II from 697302-695107, reverse complement, Verified ORF, "Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span"
>YBR239C ERT1 SGDID:S000000443, Chr II from 699943-698354, reverse complement, Uncharacterized ORF, "Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition"
>YBR240C THI2 SGDID:S000000444, Chr II from 701842-700490, reverse complement, Verified ORF, "Zinc finger protein of the Zn(II)2Cys6 type, probable transcriptional activator of thiamine biosynthetic genes"
>YBR241C YBR241C SGDID:S000000445, Chr II from 704055-702589, reverse complement, Uncharacterized ORF, "Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene"
>YBR242W YBR242W SGDID:S000000446, Chr II from 704670-705386, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene"
>YBR243C ALG7 SGDID:S000000447, Chr II from 706793-705447, reverse complement, Verified ORF, "UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin"
>YBR244W GPX2 SGDID:S000000448, Chr II from 707528-708016, Verified ORF, "Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress"
>YBR245C ISW1 SGDID:S000000449, Chr II from 711539-708150, reverse complement, Verified ORF, "Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation, and a complex with Ioc3p to repress transcription initiation"
>YBR246W RRT2 SGDID:S000000450, Chr II from 711591-712754, Uncharacterized ORF, "Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; null mutants display a weak carboxypeptidase Y missorting/secretion phenotype"
>YBR247C ENP1 SGDID:S000000451, Chr II from 714455-713004, reverse complement, Verified ORF, "Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus"
>YBR248C HIS7 SGDID:S000000452, Chr II from 716465-714807, reverse complement, Verified ORF, "Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth and sixth steps of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor"
>YBR249C ARO4 SGDID:S000000453, Chr II from 717994-716882, reverse complement, Verified ORF, "3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan"
>YBR250W SPO23 SGDID:S000000454, Chr II from 719033-720604, Verified ORF, "Protein of unknown function; associates with meiosis-specific protein Spo1p"
>YBR251W MRPS5 SGDID:S000000455, Chr II from 721390-722313, Verified ORF, "Mitochondrial ribosomal protein of the small subunit"
>YBR252W DUT1 SGDID:S000000456, Chr II from 722611-723054, Verified ORF, "dUTPase, catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability"
>YBR253W SRB6 SGDID:S000000457, Chr II from 723270-723635, Verified ORF, "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation"
>YBR254C TRS20 SGDID:S000000458, Chr II from 724263-723736, reverse complement, Verified ORF, "One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder"
>YBR255C-A YBR255C-A SGDID:S000007649, Chr II from 726917-726618,727074-727012, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; may interact with respiratory chain complexes III (ubiquinol-cytochrome c reductase) or IV (cytochrome c oxidase); identified by sequence comparison with hemiascomycetous yeast species"
>YBR255W MTC4 SGDID:S000000459, Chr II from 724456-726540, Verified ORF, "Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1"
>YBR256C RIB5 SGDID:S000000460, Chr II from 728102-727386, reverse complement, Verified ORF, "Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway"
>YBR257W POP4 SGDID:S000000461, Chr II from 728885-729724, Verified ORF, "Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in RNase P"
>YBR258C SHG1 SGDID:S000000462, Chr II from 730162-729734, reverse complement, Verified ORF, "Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres"
>YBR259W YBR259W SGDID:S000000463, Chr II from 730387-732453, Uncharacterized ORF, "Putative protein of unknown function; YBR259W is not an essential gene"
>YBR260C RGD1 SGDID:S000000464, Chr II from 734639-732639, reverse complement, Verified ORF, "GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization"
>YBR261C TAE1 SGDID:S000000465, Chr II from 735530-734832, reverse complement, Verified ORF, "AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm"
>YBR262C AIM5 SGDID:S000000466, Chr II from 736040-735720, reverse complement, Verified ORF, "Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss"
>YBR263W SHM1 SGDID:S000000467, Chr II from 736264-737736, Verified ORF, "Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine"
>YBR264C YPT10 SGDID:S000000468, Chr II from 738369-737770, reverse complement, Verified ORF, "Rab family GTP-binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles"
>YBR265W TSC10 SGDID:S000000469, Chr II from 738582-739544, Verified ORF, "3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family"
>YBR266C SLM6 SGDID:S000000470, Chr II from 740388-739936, reverse complement, Dubious ORF, "Protein with a potential role in actin cytoskeleton organization; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase"
>YBR267W REI1 SGDID:S000000471, Chr II from 739841-741022, Verified ORF, "Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network"
>YBR268W MRPL37 SGDID:S000000472, Chr II from 741299-741616, Verified ORF, "Mitochondrial ribosomal protein of the large subunit"
>YBR269C FMP21 SGDID:S000000473, Chr II from 742576-742160, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YBR270C BIT2 SGDID:S000000474, Chr II from 744398-742761, reverse complement, Uncharacterized ORF, "Subunit of TORC2, a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; similar to Bit61p"
>YBR271W YBR271W SGDID:S000000475, Chr II from 744852-746111, Uncharacterized ORF, "Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; predicted to be involved in ribosome biogenesis"
>YBR272C HSM3 SGDID:S000000476, Chr II from 747803-746361, reverse complement, Verified ORF, "Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b"
>YBR273C UBX7 SGDID:S000000477, Chr II from 749371-748061, reverse complement, Verified ORF, "UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p"
>YBR274W CHK1 SGDID:S000000478, Chr II from 749594-751177, Verified ORF, "Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase"
>YBR275C RIF1 SGDID:S000000479, Chr II from 757106-751356, reverse complement, Verified ORF, "Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation"
>YBR276C PPS1 SGDID:S000000480, Chr II from 760043-757620, reverse complement, Verified ORF, "Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle"
>YBR277C YBR277C SGDID:S000000481, Chr II from 760616-760215, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR278W"
>YBR278W DPB3 SGDID:S000000482, Chr II from 760294-760899, Verified ORF, "Third-largest subunit of DNA polymerase II (DNA polymerase epsilon), required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; mRNA abundance peaks at the G1/S boundary of the cell cycle"
>YBR279W PAF1 SGDID:S000000483, Chr II from 761257-762594, Verified ORF, "Component of the Paf1p complex that binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; homolog of human PD2/hPAF1"
>YBR280C SAF1 SGDID:S000000484, Chr II from 764697-762784, reverse complement, Verified ORF, "F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1"
>YBR281C DUG2 SGDID:S000000485, Chr II from 767606-764970, reverse complement, Verified ORF, "Probable di- and tri-peptidase; forms a complex with Dug1p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)"
>YBR282W MRPL27 SGDID:S000000486, Chr II from 768240-768680, Verified ORF, "Mitochondrial ribosomal protein of the large subunit"
>YBR283C SSH1 SGDID:S000000487, Chr II from 770415-768943, reverse complement, Verified ORF, "Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential"
>YBR284W YBR284W SGDID:S000000488, Chr II from 771239-773632, Uncharacterized ORF, "Putative protein of unknown function; YBR284W is not an essential gene; null mutant exhibits decreased resistance to rapamycin and wortmannin and synthetic phenotype with alpha-synuclein"
>YBR285W YBR285W SGDID:S000000489, Chr II from 773922-774356, Uncharacterized ORF, "Putative protein of unknown function; YBR285W is not an essential gene"
>YBR286W APE3 SGDID:S000000490, Chr II from 774700-776313, Verified ORF, "Vacuolar aminopeptidase Y, processed to mature form by Prb1p"
>YBR287W YBR287W SGDID:S000000491, Chr II from 776571-777854, Uncharacterized ORF, "Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene"
>YBR288C APM3 SGDID:S000000492, Chr II from 779463-778012, reverse complement, Verified ORF, "Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway"
>YBR289W SNF5 SGDID:S000000493, Chr II from 779667-782384, Verified ORF, "Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p"
>YBR290W BSD2 SGDID:S000000494, Chr II from 782591-783556, Verified ORF, "Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification"
>YBR291C CTP1 SGDID:S000000495, Chr II from 784572-783673, reverse complement, Verified ORF, "Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family"
>YBR292C YBR292C SGDID:S000000496, Chr II from 785073-784702, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene"
>YBR293W VBA2 SGDID:S000000497, Chr II from 787006-788430, Verified ORF, "Permease of basic amino acids in the vacuolar membrane"
>YBR294W SUL1 SGDID:S000000498, Chr II from 789235-791814, Verified ORF, "High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates"
>YBR295W PCA1 SGDID:S000000499, Chr II from 792849-796499, Verified ORF, "Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; stabilized by Cd binding, which prevents ubiquitination; S288C and other lab strains contain a G970R mutation which eliminates Cd transport function"
>YBR296C PHO89 SGDID:S000000500, Chr II from 798522-796798, reverse complement, Verified ORF, "Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p"
>YBR296C-A YBR296C-A SGDID:S000028605, Chr II from 800242-800123, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YBR297W MAL33 SGDID:S000000501, Chr II from 800523-801929, Verified ORF, "MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C"
>YBR298C MAL31 SGDID:S000000502, Chr II from 804475-802631, reverse complement, Verified ORF, "Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C"
>YBR298C-A YBR298C-A SGDID:S000028606, Chr II from 805256-805035, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YBR299W MAL32 SGDID:S000000503, Chr II from 805351-807105, Verified ORF, "Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose"
>YBR300C YBR300C SGDID:S000000504, Chr II from 809097-808600, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene"
>YBR301W PAU24 SGDID:S000000505, Chr II from 809057-809419, Verified ORF, "Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth"
>YBR302C COS2 SGDID:S000000506, Chr II from 811479-810340, reverse complement, Verified ORF, "Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins"
>YCL001W RER1 SGDID:S000000507, Chr III from 111916-112482, Verified ORF, "Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER"
>YCL001W-A YCL001W-A SGDID:S000007221, Chr III from 113080-113541, Uncharacterized ORF, "Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III"
>YCL001W-B YCL001W-B SGDID:S000007596, Chr III from 113770-114024, Uncharacterized ORF, "Putative protein of unknown function; YCL001W-B gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III"
>YCL002C YCL002C SGDID:S000000508, Chr III from 111557-110808,111675-111634, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; YCL002C is not an essential gene"
>YCL004W PGS1 SGDID:S000000510, Chr III from 109105-110670, Verified ORF, "Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis"
>YCL005W LDB16 SGDID:S000000511, Chr III from 108021-108791, Verified ORF, "Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria"
>YCL005W-A VMA9 SGDID:S000028508, Chr III from 107023-107033,107111-107191,107288-107417, Verified ORF, "Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis"
>YCL007C YCL007C SGDID:S000000513, Chr III from 107366-106974, reverse complement, Dubious ORF, "Dubious ORF unlikely to encode a protein; overlaps verified ORF YCL005W-A; mutations in YCL007C were thought to confer sensitivity to calcofluor white, but this phenotype was later shown to be due to the defect in YCL005W-A"
>YCL008C STP22 SGDID:S000000514, Chr III from 106853-105696, reverse complement, Verified ORF, "Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype"
>YCL009C ILV6 SGDID:S000000515, Chr III from 105548-104619, reverse complement, Verified ORF, "Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria"
>YCL010C SGF29 SGDID:S000000516, Chr III from 104350-103571, reverse complement, Verified ORF, "Probable subunit of SAGA histone acetyltransferase complex"
>YCL011C GBP2 SGDID:S000000517, Chr III from 103358-102075, reverse complement, Verified ORF, "Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Hrb1p and Npl3p; also binds single-stranded telomeric repeat sequence in vitro"
>YCL012C YCL012C SGDID:S000029705, Chr III from 101633-101317,101788-101701, reverse complement, Verified ORF, "Putative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene"
>YCL014W BUD3 SGDID:S000000520, Chr III from 96281-101191, Verified ORF, "Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding"
>YCL016C DCC1 SGDID:S000000521, Chr III from 95763-94621, reverse complement, Verified ORF, "Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance"
>YCL017C NFS1 SGDID:S000000522, Chr III from 94270-92777, reverse complement, Verified ORF, "Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria"
>YCL018W LEU2 SGDID:S000000523, Chr III from 91324-92418, Verified ORF, "Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway"
>YCL019W YCL019W SGDID:S000000524, Chr III from 85102-86391,86393-90415, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YCL020W YCL020W SGDID:S000000525, Chr III from 85102-86418, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YCL021W-A YCL021W-A SGDID:S000007549, Chr III from 83620-83997, Uncharacterized ORF, "Putative protein of unknown function"
>YCL022C YCL022C SGDID:S000000527, Chr III from 82085-81570, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W"
>YCL023C YCL023C SGDID:S000000528, Chr III from 79296-78949, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4"
>YCL024W KCC4 SGDID:S000000529, Chr III from 79162-82275, Verified ORF, "Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p"
>YCL025C AGP1 SGDID:S000000530, Chr III from 77919-76018, reverse complement, Verified ORF, "Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)"
>YCL026C-A FRM2 SGDID:S000000589, Chr III from 75285-74704, reverse complement, Verified ORF, "Protein of unknown function, involved in the integration of lipid signaling pathways with cellular homeostasis; expression induced in cells treated with the mycotoxin patulin; has similarity to bacterial nitroreductases"
>YCL026C-B HBN1 SGDID:S000007548, Chr III from 73986-73405, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion"
>YCL027W FUS1 SGDID:S000000532, Chr III from 71803-73341, Verified ORF, "Membrane protein localized to the shmoo tip, required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate"
>YCL028W RNQ1 SGDID:S000000533, Chr III from 70150-71367, Verified ORF, "[PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate"
>YCL029C BIK1 SGDID:S000000534, Chr III from 69921-68599, reverse complement, Verified ORF, "Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170"
>YCL030C HIS4 SGDID:S000000535, Chr III from 68333-65934, reverse complement, Verified ORF, "Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis"
>YCL031C RRP7 SGDID:S000000536, Chr III from 65568-64675, reverse complement, Verified ORF, "Essential protein involved in rRNA processing and ribosome biogenesis"
>YCL032W STE50 SGDID:S000000537, Chr III from 63441-64481, Verified ORF, "Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction"
>YCL033C MXR2 SGDID:S000000538, Chr III from 63282-62776, reverse complement, Verified ORF, "Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan"
>YCL034W LSB5 SGDID:S000000539, Chr III from 61658-62722, Verified ORF, "Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat"
>YCL035C GRX1 SGDID:S000000540, Chr III from 61173-60841, reverse complement, Verified ORF, "Hydroperoxide and superoxide-radical responsive heat-stable glutathione-dependent disulfide oxidoreductase with active site cysteine pair; protects cells from oxidative damage"
>YCL036W GFD2 SGDID:S000000541, Chr III from 59026-60726, Verified ORF, "Protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation"
>YCL037C SRO9 SGDID:S000000542, Chr III from 58678-57374, reverse complement, Verified ORF, "Cytoplasmic RNA-binding protein that associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif"
>YCL038C ATG22 SGDID:S000000543, Chr III from 56527-54941, reverse complement, Verified ORF, "Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation"
>YCL039W GID7 SGDID:S000000544, Chr III from 52645-54882, Verified ORF, "Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions"
>YCL040W GLK1 SGDID:S000000545, Chr III from 50838-52340, Verified ORF, "Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources"
>YCL041C YCL041C SGDID:S000000546, Chr III from 50627-50133, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W"
>YCL042W YCL042W SGDID:S000000547, Chr III from 50584-50943, Uncharacterized ORF, "Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm"
>YCL043C PDI1 SGDID:S000000548, Chr III from 50221-48653, reverse complement, Verified ORF, "Protein disulfide isomerase, multifunctional protein resident in the endoplasmic reticulum lumen, essential for the formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds"
>YCL044C MGR1 SGDID:S000000549, Chr III from 48364-47111, reverse complement, Verified ORF, "Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA"
>YCL045C EMC1 SGDID:S000000550, Chr III from 46905-44623, reverse complement, Verified ORF, "Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p"
>YCL046W YCL046W SGDID:S000000551, Chr III from 46640-46963, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C"
>YCL047C YCL047C SGDID:S000000552, Chr III from 44437-43661, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YCL048W SPS22 SGDID:S000000553, Chr III from 42165-43556, Verified ORF, "Protein of unknown function, redundant with Sps2p for the organization of the beta-glucan layer of the spore wall"
>YCL048W-A YCL048W-A SGDID:S000087203, Chr III from 41488-41727, Uncharacterized ORF, "Putative protein of unknown function"
>YCL049C YCL049C SGDID:S000000554, Chr III from 40724-39786, reverse complement, Uncharacterized ORF, "Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene"
>YCL050C APA1 SGDID:S000000555, Chr III from 38801-37836, reverse complement, Verified ORF, "Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase I (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa2p"
>YCL051W LRE1 SGDID:S000000556, Chr III from 35865-37616, Verified ORF, "Protein involved in control of cell wall structure and stress response; inhibits Cbk1p protein kinase activity; overproduction confers resistance to cell-wall degrading enzymes"
>YCL052C PBN1 SGDID:S000000557, Chr III from 35393-34143, reverse complement, Verified ORF, "Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X"
>YCL054W SPB1 SGDID:S000000559, Chr III from 31449-33974, Verified ORF, "AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants"
>YCL055W KAR4 SGDID:S000000560, Chr III from 27929-28936, Verified ORF, "Transcription factor required for gene regulation in response to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone"
>YCL056C YCL056C SGDID:S000000561, Chr III from 27359-26925, reverse complement, Uncharacterized ORF, "Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant displays decreased thermotolerance"
>YCL057C-A YCL057C-A SGDID:S000007547, Chr III from 24325-24032, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YCL057W PRD1 SGDID:S000000562, Chr III from 24768-26906, Verified ORF, "Zinc metalloendopeptidase, found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins"
>YCL058C FYV5 SGDID:S000000563, Chr III from 23981-23523, reverse complement, Verified ORF, "Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis"
>YCL058W-A ADF1 SGDID:S000028518, Chr III from 23584-23925, Verified ORF, "Transcriptional repressor encoded by the antisense strand of the FYV5 gene; negatively regulates transcription of FYV5 by binding to the promoter on the sense strand"
>YCL059C KRR1 SGDID:S000000564, Chr III from 23379-22429, reverse complement, Verified ORF, "Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit"
>YCL061C MRC1 SGDID:S000000566, Chr III from 22106-18816, reverse complement, Verified ORF, "S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres"
>YCL063W VAC17 SGDID:S000000568, Chr III from 17290-18561, Verified ORF, "Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p"
>YCL064C CHA1 SGDID:S000000569, Chr III from 16880-15798, reverse complement, Verified ORF, "Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine"
>YCL065W YCL065W SGDID:S000000570, Chr III from 13751-14119, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps HMLALPHA1"
>YCL066W HMLALPHA1 SGDID:S000000571, Chr III from 13282-13809, Verified ORF, "Silenced copy of ALPHA1 at HML, encoding a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression"
>YCL067C HMLALPHA2 SGDID:S000000572, Chr III from 13018-12386, reverse complement, Verified ORF, "Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression"
>YCL068C YCL068C SGDID:S000000573, Chr III from 12285-11503, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YCL069W VBA3 SGDID:S000000574, Chr III from 9706-11082, Verified ORF, "Permease of basic amino acids in the vacuolar membrane"
>YCL073C YCL073C SGDID:S000000575, Chr III from 8326-6479, reverse complement, Uncharacterized ORF, "Protein of unconfirmed function; displays a topology characteristic of the Major Facilitators Superfamily of membrane proteins; coding sequence 98% identical to that of YKR106W"
>YCL074W YCL074W SGDID:S000000579, Chr III from 2824-3750, pseudogene, "Pseudogene: encodes fragment of Ty Pol protein"
>YCL075W YCL075W SGDID:S000000580, Chr III from 2126-2566, pseudogene, "Pseudogene: encodes fragment of Ty Pol protein"
>YCL076W YCL076W SGDID:S000000581, Chr III from 1392-2135, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YCR001W YCR001W SGDID:S000000594, Chr III from 115685-115999, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene"
>YCR002C CDC10 SGDID:S000000595, Chr III from 118348-117380, reverse complement, Verified ORF, "Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM"
>YCR003W MRPL32 SGDID:S000000596, Chr III from 118620-119171, Verified ORF, "Mitochondrial ribosomal protein of the large subunit"
>YCR004C YCP4 SGDID:S000000597, Chr III from 120318-119575, reverse complement, Verified ORF, "Protein of unknown function, has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YCR005C CIT2 SGDID:S000000598, Chr III from 122328-120946, reverse complement, Verified ORF, "Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors"
>YCR006C YCR006C SGDID:S000000599, Chr III from 123003-122530, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YCR007C YCR007C SGDID:S000000600, Chr III from 126730-126011, reverse complement, Uncharacterized ORF, "Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene"
>YCR008W SAT4 SGDID:S000000601, Chr III from 128470-130281, Verified ORF, "Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p"
>YCR009C RVS161 SGDID:S000000602, Chr III from 131542-130745, reverse complement, Verified ORF, "Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress"
>YCR010C ADY2 SGDID:S000000603, Chr III from 133124-132273, reverse complement, Verified ORF, "Acetate transporter required for normal sporulation; phosphorylated in mitochondria"
>YCR011C ADP1 SGDID:S000000604, Chr III from 136873-133724, reverse complement, Verified ORF, "Putative ATP-dependent permease of the ABC transporter family of proteins"
>YCR012W PGK1 SGDID:S000000605, Chr III from 137746-138996, Verified ORF, "3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis"
>YCR013C YCR013C SGDID:S000000606, Chr III from 139049-138402, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant"
>YCR014C POL4 SGDID:S000000607, Chr III from 140933-139185, reverse complement, Verified ORF, "DNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta"
>YCR015C YCR015C SGDID:S000000608, Chr III from 142170-141217, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; YCR015C is not an essential gene"
>YCR016W YCR016W SGDID:S000000609, Chr III from 143634-144506, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; predicted to be involved in ribosome biogenesis"
>YCR017C CWH43 SGDID:S000000610, Chr III from 147634-144773, reverse complement, Verified ORF, "Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion"
>YCR018C SRD1 SGDID:S000000611, Chr III from 148903-148238, reverse complement, Verified ORF, "Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation"
>YCR018C-A YCR018C-A SGDID:S000007230, Chr III from 151862-151608, reverse complement, Dubious ORF, "Putative protein of unknown function; encoded opposite a Ty1 LTR"
>YCR019W MAK32 SGDID:S000000612, Chr III from 152837-153928, Verified ORF, "Protein necessary for structural stability of L-A double-stranded RNA-containing particles"
>YCR020C PET18 SGDID:S000000613, Chr III from 154659-154012, reverse complement, Verified ORF, "Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin"
>YCR020C-A MAK31 SGDID:S000000614, Chr III from 155096-154830, reverse complement, Verified ORF, "Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family"
>YCR020W-B HTL1 SGDID:S000006439, Chr III from 155320-155556, Verified ORF, "Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance"
>YCR021C HSP30 SGDID:S000000615, Chr III from 157107-156109, reverse complement, Verified ORF, "Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase"
>YCR022C YCR022C SGDID:S000000616, Chr III from 157765-157421, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene"
>YCR023C YCR023C SGDID:S000000617, Chr III from 160373-158538, reverse complement, Verified ORF, "Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene"
>YCR024C SLM5 SGDID:S000000618, Chr III from 162222-160744, reverse complement, Verified ORF, "Mitochondrial asparaginyl-tRNA synthetase"
>YCR024C-A PMP1 SGDID:S000000619, Chr III from 163067-162945, reverse complement, Verified ORF, "Small single-membrane span proteolipid that functions as a regulatory subunit of the plasma membrane H(+)-ATPase Pma1p, forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines"
>YCR024C-B YCR024C-B SGDID:S000028818, Chr III from 162865-162599, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by expression profiling and mass spectrometry"
>YCR025C YCR025C SGDID:S000000620, Chr III from 163856-163446, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene"
>YCR026C NPP1 SGDID:S000000621, Chr III from 166339-164111, reverse complement, Verified ORF, "Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation"
>YCR027C RHB1 SGDID:S000000622, Chr III from 167999-167370, reverse complement, Verified ORF, "Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins"
>YCR028C FEN2 SGDID:S000000623, Chr III from 172424-170886, reverse complement, Verified ORF, "Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph"
>YCR028C-A RIM1 SGDID:S000007222, Chr III from 173115-172950,173440-173199, reverse complement, Verified ORF, "Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication"
>YCR030C SYP1 SGDID:S000000626, Chr III from 176438-173826, reverse complement, Verified ORF, "Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization"
>YCR031C RPS14A SGDID:S000000627, Chr III from 177906-177500,178220-178214, reverse complement, Verified ORF, "Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins"
>YCR032W BPH1 SGDID:S000000628, Chr III from 179520-186023, Verified ORF, "PProtein homologous to human Chediak-Higashi syndrome and murine Beige proteins, which are implicated in disease syndromes due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting"
>YCR033W SNT1 SGDID:S000000629, Chr III from 186489-190169, Verified ORF, "Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance"
>YCR034W FEN1 SGDID:S000000630, Chr III from 190592-191635, Verified ORF, "Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway"
>YCR035C RRP43 SGDID:S000000631, Chr III from 193018-191834, reverse complement, Verified ORF, "Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8)"
>YCR036W RBK1 SGDID:S000000632, Chr III from 193297-194298, Verified ORF, "Putative ribokinase"
>YCR037C PHO87 SGDID:S000000633, Chr III from 197185-194414, reverse complement, Verified ORF, "Low-affinity inorganic phosphate (Pi) transporter, involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments"
>YCR038C BUD5 SGDID:S000000634, Chr III from 199549-197621, reverse complement, Verified ORF, "GTP/GDP exchange factor for Rsr1p (Bud1p) required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types"
>YCR038W-A YCR038W-A SGDID:S000007597, Chr III from 199293-199418, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene BUD5/YCR038C; identified by homology with hemiascomycetous yeast species"
>YCR039C MATALPHA2 SGDID:S000000635, Chr III from 200178-199546, reverse complement, Verified ORF, "Homeobox-domain protein that, with Mcm1p, represses a-specific genes in haploids; acts with A1p to repress transcription of haploid-specific genes in diploids; one of two genes encoded by the MATalpha mating type cassette"
>YCR040W MATALPHA1 SGDID:S000000636, Chr III from 200442-200969, Verified ORF, "Transcriptional co-activator involved in regulation of mating-type-specific gene expression; targets the transcription factor Mcm1p to the promoters of alpha-specific genes; one of two genes encoded by the MATalpha mating type cassette"
>YCR041W YCR041W SGDID:S000000637, Chr III from 200911-201243, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YCR042C TAF2 SGDID:S000000638, Chr III from 205397-201174, reverse complement, Verified ORF, "TFIID subunit (150 kDa), involved in RNA polymerase II transcription initiation"
>YCR043C YCR043C SGDID:S000000639, Chr III from 206644-206261, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene"
>YCR044C PER1 SGDID:S000000640, Chr III from 207950-206877, reverse complement, Verified ORF, "Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1"
>YCR045C RRT12 SGDID:S000000641, Chr III from 209610-208135, reverse complement, Verified ORF, "Probable subtilisin-family protease with a role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores"
>YCR045W-A YCR045W-A SGDID:S000028607, Chr III from 208751-209101, Dubious ORF, "Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with YCR045C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching"
>YCR046C IMG1 SGDID:S000000642, Chr III from 210423-209914, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome"
>YCR047C BUD23 SGDID:S000000643, Chr III from 211545-210718, reverse complement, Verified ORF, "Methyltransferase, methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern"
>YCR047W-A YCR047W-A SGDID:S000028608, Chr III from 211301-211507, Dubious ORF, "Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with YCR047C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching"
>YCR048W ARE1 SGDID:S000000644, Chr III from 211929-213761, Verified ORF, "Acyl-CoA:sterol acyltransferase, isozyme of Are2p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen"
>YCR049C YCR049C SGDID:S000000645, Chr III from 212317-211871, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YCR050C YCR050C SGDID:S000000646, Chr III from 213772-213464, reverse complement, Uncharacterized ORF, "Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein"
>YCR051W YCR051W SGDID:S000000647, Chr III from 214071-214739, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene"
>YCR052W RSC6 SGDID:S000000648, Chr III from 214994-216445, Verified ORF, "Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p"
>YCR053W THR4 SGDID:S000000649, Chr III from 216697-218241, Verified ORF, "Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway"
>YCR054C CTR86 SGDID:S000000650, Chr III from 220067-218376, reverse complement, Verified ORF, "Essential protein of unknown function; upstream region contains a Gcn4p responsive site suggesting a possible role in amino acid biosynthesis"
>YCR057C PWP2 SGDID:S000000653, Chr III from 223228-220457, reverse complement, Verified ORF, "Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis"
>YCR059C YIH1 SGDID:S000000655, Chr III from 224230-223454, reverse complement, Verified ORF, "Protein that inhibits activation of Gcn2p, an eIF2 alpha subunit protein kinase, by competing for Gcn1p binding, thus impacting gene expression in response to starvation; has sequence and functional similarity to the mouse IMPACT gene"
>YCR060W TAH1 SGDID:S000000656, Chr III from 224399-224734, Verified ORF, "HSP90 cofactor; interacts with Hsp82p, Pih1p, Rvb1 and Rvb2, contains a single TPR domain with at least two TPR motifs"
>YCR061W YCR061W SGDID:S000000657, Chr III from 225563-227458, Uncharacterized ORF, "Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation"
>YCR063W BUD31 SGDID:S000000659, Chr III from 228318-228791, Verified ORF, "Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern"
>YCR064C YCR064C SGDID:S000000660, Chr III from 228505-228095, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31"
>YCR065W HCM1 SGDID:S000000661, Chr III from 229310-231004, Verified ORF, "Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role"
>YCR066W RAD18 SGDID:S000000662, Chr III from 231500-232963, Verified ORF, "E3 ubiqutin ligase, forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair"
>YCR067C SED4 SGDID:S000000663, Chr III from 236322-233125, reverse complement, Verified ORF, "Integral endoplasmic reticulum membrane protein, functions as a positive regulator of Sar1p probably through inhibition of GTPase activation by Sec23p; binds Sec16p, participates in vesicle formation, similar to Sec12p"
>YCR068W ATG15 SGDID:S000000664, Chr III from 237214-238776, Verified ORF, "Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway"
>YCR069W CPR4 SGDID:S000000665, Chr III from 239055-240011, Verified ORF, "Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway"
>YCR071C IMG2 SGDID:S000000667, Chr III from 240543-240103, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the large subunit"
>YCR072C RSA4 SGDID:S000000668, Chr III from 242352-240805, reverse complement, Verified ORF, "WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus"
>YCR073C SSK22 SGDID:S000000669, Chr III from 246583-242588, reverse complement, Verified ORF, "MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p"
>YCR073W-A SOL2 SGDID:S000000718, Chr III from 246963-247910, Verified ORF, "Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol1p, Sol3p, and Sol4p"
>YCR075C ERS1 SGDID:S000000671, Chr III from 248815-248033, reverse complement, Verified ORF, "Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains"
>YCR075W-A YCR075W-A SGDID:S000028519, Chr III from 248975-249202, Uncharacterized ORF, "Putative protein of unknown function; identified by homology to Ashbya gossypii"
>YCR076C YCR076C SGDID:S000000672, Chr III from 250045-249293, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; YCR076C is not an essential gene"
>YCR077C PAT1 SGDID:S000000673, Chr III from 252628-250238, reverse complement, Verified ORF, "Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; functionally linked to Pab1p"
>YCR079W PTC6 SGDID:S000002133, Chr III from 252845-254173, Verified ORF, "Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase"
>YCR081C-A YCR081C-A SGDID:S000028609, Chr III from 258651-258415, reverse complement, Dubious ORF, "Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with SRB8/YCR081W; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching"
>YCR081W SRB8 SGDID:S000000677, Chr III from 254371-258654, Verified ORF, "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression"
>YCR082W AHC2 SGDID:S000000678, Chr III from 258883-259269, Verified ORF, "Protein of unknown function, putative transcriptional regulator; proposed to be a Ada Histone acetyltransferase complex component; GFP tagged protein is localized to the cytoplasm and nucleus"
>YCR083W TRX3 SGDID:S000000679, Chr III from 259578-259961, Verified ORF, "Mitochondrial thioredoxin, highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p"
>YCR084C TUP1 SGDID:S000000680, Chr III from 262452-260311, reverse complement, Verified ORF, "General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes"
>YCR085W YCR085W SGDID:S000000681, Chr III from 262916-263269, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YCR086W CSM1 SGDID:S000000682, Chr III from 263392-263964, Verified ORF, "Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation"
>YCR087C-A YCR087C-A SGDID:S000007223, Chr III from 264467-264006, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene"
>YCR087W YCR087W SGDID:S000000683, Chr III from 263976-264491, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene"
>YCR088W ABP1 SGDID:S000000684, Chr III from 265068-266846, Verified ORF, "Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization"
>YCR089W FIG2 SGDID:S000000685, Chr III from 267434-272263, Verified ORF, "Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating"
>YCR090C YCR090C SGDID:S000000686, Chr III from 272863-272315, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene"
>YCR091W KIN82 SGDID:S000000687, Chr III from 274404-276566, Verified ORF, "Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p"
>YCR092C MSH3 SGDID:S000000688, Chr III from 279820-276764, reverse complement, Verified ORF, "Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability"
>YCR093W CDC39 SGDID:S000000689, Chr III from 280117-286443, Verified ORF, "Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor"
>YCR094W CDC50 SGDID:S000000690, Chr III from 286762-287937, Verified ORF, "Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Ynr048wp and Lem3p"
>YCR095C OCA4 SGDID:S000000691, Chr III from 289258-288170, reverse complement, Uncharacterized ORF, "Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts"
>YCR095W-A YCR095W-A SGDID:S000029724, Chr III from 289639-289797, Uncharacterized ORF, "Putative protein of unknown function"
>YCR096C HMRA2 SGDID:S000000692, Chr III from 293538-293179, reverse complement, Verified ORF, "Silenced copy of a2 at HMR; similarity to Alpha2p; required along with a1p for inhibiting expression of the HO endonuclease in a/alpha HO/HO diploid cells with an active mating-type interconversion system"
>YCR097W HMRA1 SGDID:S000000694, Chr III from 293835-293939,293994-294239,294292-294321, Verified ORF, "Silenced copy of a1 at HMR; homeobox corepressor that interacts with Alpha2p to repress haploid-specific gene transcription in diploid cells"
>YCR097W-A YCR097W-A SGDID:S000007632, Chr III from 294439-294705, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by homology to a hemiascomycetous yeast protein"
>YCR098C GIT1 SGDID:S000000695, Chr III from 298605-297049, reverse complement, Verified ORF, "Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability"
>YCR099C YCR099C SGDID:S000000696, Chr III from 301299-300832, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YCR100C YCR100C SGDID:S000000697, Chr III from 302221-301271, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YCR101C YCR101C SGDID:S000000698, Chr III from 303030-302482, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene"
>YCR102C YCR102C SGDID:S000000699, Chr III from 305467-304361, reverse complement, Uncharacterized ORF, "Putative protein of unknown function, involved in copper metabolism; similar to C. carbonum toxD gene; member of the quinone oxidoreductase family"
>YCR102W-A YCR102W-A SGDID:S000007231, Chr III from 306735-306932, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YCR104W PAU3 SGDID:S000000701, Chr III from 307801-308175, Verified ORF, "Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme"
>YCR105W ADH7 SGDID:S000000702, Chr III from 309070-310155, Verified ORF, "NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance"
>YCR106W RDS1 SGDID:S000000703, Chr III from 310958-313456, Verified ORF, "Zinc cluster transcription factor involved in conferring resistance to cycloheximide"
>YCR107W AAD3 SGDID:S000000704, Chr III from 313890-314981, Verified ORF, "Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role"
>YCR108C YCR108C SGDID:S000028536, Chr III from 316188-315997, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by fungal homology and RT-PCR"
>YDL001W RMD1 SGDID:S000002159, Chr IV from 447984-449276, Verified ORF, "Cytoplasmic protein required for sporulation"
>YDL002C NHP10 SGDID:S000002160, Chr IV from 447578-446967, reverse complement, Verified ORF, "Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair"
>YDL003W MCD1 SGDID:S000002161, Chr IV from 444683-446383, Verified ORF, "Essential subunit of the cohesin complex required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase"
>YDL004W ATP16 SGDID:S000002162, Chr IV from 443029-443511, Verified ORF, "Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated"
>YDL005C MED2 SGDID:S000002163, Chr IV from 442309-441014, reverse complement, Verified ORF, "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation"
>YDL006W PTC1 SGDID:S000002164, Chr IV from 439909-440754, Verified ORF, "Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation"
>YDL007C-A YDL007C-A SGDID:S000113557, Chr IV from 436824-436567, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YDL007W RPT2 SGDID:S000002165, Chr IV from 438047-439360, Verified ORF, "One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle"
>YDL008W APC11 SGDID:S000002166, Chr IV from 433497-433994, Verified ORF, "Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition"
>YDL009C YDL009C SGDID:S000002167, Chr IV from 433248-432925, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YDL010W; YDL009C is not an essential gene"
>YDL010W GRX6 SGDID:S000002168, Chr IV from 432330-433025, Verified ORF, "Cis-golgi localized monothiol glutaredoxin that binds an iron-sulfur cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; functional overlap with GRX7"
>YDL011C YDL011C SGDID:S000002169, Chr IV from 432631-432308, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W"
>YDL012C YDL012C SGDID:S000002170, Chr IV from 431386-431108,431517-431473, reverse complement, Verified ORF, "Tail-anchored plasma membrane protein containing a conserved CYSTM module, possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype"
>YDL013W SLX5 SGDID:S000002171, Chr IV from 429067-430926, Verified ORF, "Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers"
>YDL014W NOP1 SGDID:S000002172, Chr IV from 427364-428347, Verified ORF, "Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin"
>YDL015C TSC13 SGDID:S000002173, Chr IV from 426934-426002, reverse complement, Verified ORF, "Enoyl reductase that catalyzes the last step in each cycle of very long chain fatty acid elongation, localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions, coimmunoprecipitates with elongases Fen1p and Sur4p"
>YDL016C YDL016C SGDID:S000002174, Chr IV from 425872-425570, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CDC7/YDL153C, the catalytic subunit of a complex that regulates DNA replication"
>YDL017W CDC7 SGDID:S000002175, Chr IV from 424209-425732, Verified ORF, "DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in S phase through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression"
>YDL018C ERP3 SGDID:S000002176, Chr IV from 423510-422833, reverse complement, Verified ORF, "Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport"
>YDL019C OSH2 SGDID:S000002177, Chr IV from 421514-417663, reverse complement, Verified ORF, "Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability"
>YDL020C RPN4 SGDID:S000002178, Chr IV from 416708-415113, reverse complement, Verified ORF, "Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses"
>YDL021W GPM2 SGDID:S000002179, Chr IV from 413953-414888, Verified ORF, "Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event"
>YDL022C-A YDL022C-A SGDID:S000028537, Chr IV from 410056-409808, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR"
>YDL022W GPD1 SGDID:S000002180, Chr IV from 411825-413000, Verified ORF, "NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p"
>YDL023C YDL023C SGDID:S000002181, Chr IV from 412081-411761, reverse complement, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance"
>YDL024C DIA3 SGDID:S000002182, Chr IV from 409857-408451, reverse complement, Verified ORF, "Protein of unknown function, involved in invasive and pseudohyphal growth"
>YDL025C RTK1 SGDID:S000002183, Chr IV from 407206-405344, reverse complement, Verified ORF, "Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1"
>YDL025W-A YDL025W-A SGDID:S000028610, Chr IV from 405410-405514, Dubious ORF, "Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the ORF YDL025C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching"
>YDL026W YDL026W SGDID:S000002184, Chr IV from 404749-405060, Dubious ORF, "Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data"
>YDL027C YDL027C SGDID:S000002185, Chr IV from 404957-403695, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene"
>YDL028C MPS1 SGDID:S000002186, Chr IV from 403291-400997, reverse complement, Verified ORF, "Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, and checkpoint protein Mad1p"
>YDL029W ARP2 SGDID:S000002187, Chr IV from 399340-399361,399485-400638, Verified ORF, "Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity"
>YDL030W PRP9 SGDID:S000002188, Chr IV from 397537-399129, Verified ORF, "Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex"
>YDL031W DBP10 SGDID:S000002189, Chr IV from 394217-397204, Verified ORF, "Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis"
>YDL032W YDL032W SGDID:S000002190, Chr IV from 393690-394001, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene"
>YDL033C SLM3 SGDID:S000002191, Chr IV from 393912-392659, reverse complement, Verified ORF, "tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)"
>YDL034W YDL034W SGDID:S000002192, Chr IV from 391783-392127, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps with verified gene GPR1/YDL035C; YDL034W is not an essential gene"
>YDL035C GPR1 SGDID:S000002193, Chr IV from 392057-389172, reverse complement, Verified ORF, "Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis"
>YDL036C PUS9 SGDID:S000002194, Chr IV from 388901-387513, reverse complement, Verified ORF, "Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence"
>YDL037C BSC1 SGDID:S000002195, Chr IV from 385587-384601, reverse complement, Verified ORF, "Protein of unconfirmed function, similar to cell surface flocculin Muc1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression"
>YDL039C PRM7 SGDID:S000002197, Chr IV from 384081-381985, reverse complement, Verified ORF, "Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements"
>YDL040C NAT1 SGDID:S000002198, Chr IV from 381438-378874, reverse complement, Verified ORF, "Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing"
>YDL041W YDL041W SGDID:S000002199, Chr IV from 378102-378455, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C"
>YDL042C SIR2 SGDID:S000002200, Chr IV from 378445-376757, reverse complement, Verified ORF, "Conserved NAD+ dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and the rDNA locus; negatively regulates initiation of DNA replication"
>YDL043C PRP11 SGDID:S000002201, Chr IV from 376480-375680, reverse complement, Verified ORF, "Subunit of the SF3a splicing factor complex, required for spliceosome assembly"
>YDL044C MTF2 SGDID:S000002202, Chr IV from 375289-373967, reverse complement, Verified ORF, "Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription"
>YDL045C FAD1 SGDID:S000002203, Chr IV from 373608-372688, reverse complement, Verified ORF, "Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin"
>YDL045W-A MRP10 SGDID:S000006430, Chr IV from 372248-372535, Verified ORF, "Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs"
>YDL046W NPC2 SGDID:S000002204, Chr IV from 371240-371761, Verified ORF, "Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes"
>YDL047W SIT4 SGDID:S000002205, Chr IV from 369771-370706, Verified ORF, "Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization"
>YDL048C STP4 SGDID:S000002206, Chr IV from 368211-366739, reverse complement, Verified ORF, "Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p"
>YDL049C KNH1 SGDID:S000002207, Chr IV from 365874-365068, reverse complement, Verified ORF, "Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance"
>YDL050C YDL050C SGDID:S000002208, Chr IV from 364817-364446, reverse complement, Dubious ORF, "Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data"
>YDL051W LHP1 SGDID:S000002209, Chr IV from 363952-364779, Verified ORF, "RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen"
>YDL052C SLC1 SGDID:S000002210, Chr IV from 363583-362672, reverse complement, Verified ORF, "1-acyl-sn-glycerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes"
>YDL053C PBP4 SGDID:S000002211, Chr IV from 362256-361699, reverse complement, Verified ORF, "Pbp1p binding protein, interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay"
>YDL054C MCH1 SGDID:S000002212, Chr IV from 361285-359825, reverse complement, Verified ORF, "Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport"
>YDL055C PSA1 SGDID:S000002213, Chr IV from 356759-355674, reverse complement, Verified ORF, "GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure"
>YDL056W MBP1 SGDID:S000002214, Chr IV from 352877-355378, Verified ORF, "Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes"
>YDL057W YDL057W SGDID:S000002215, Chr IV from 351434-352420, Uncharacterized ORF, "Putative protein of unknown function; YDL057W is not an essential gene"
>YDL058W USO1 SGDID:S000002216, Chr IV from 345665-351037, Verified ORF, "Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex"
>YDL059C RAD59 SGDID:S000002217, Chr IV from 344953-344237, reverse complement, Verified ORF, "Protein involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; homologous to Rad52p"
>YDL060W TSR1 SGDID:S000002218, Chr IV from 341619-343985, Verified ORF, "Protein required for processing of 20S pre-rRNA in the cytoplasm, associates with pre-40S ribosomal particles"
>YDL061C RPS29B SGDID:S000002219, Chr IV from 340798-340628, reverse complement, Verified ORF, "Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Ap and has similarity to rat S29 and E. coli S14 ribosomal proteins"
>YDL062W YDL062W SGDID:S000002220, Chr IV from 339857-340282, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YDL063C; YDL062W is not essential"
>YDL063C YDL063C SGDID:S000002221, Chr IV from 340134-338272, reverse complement, Verified ORF, "Protein required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus"
>YDL064W UBC9 SGDID:S000002222, Chr IV from 337487-337524,337635-338070, Verified ORF, "SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)"
>YDL065C PEX19 SGDID:S000002223, Chr IV from 337277-336249, reverse complement, Verified ORF, "Chaperone and import receptor for newly-synthesized class I peroxisomal membrane proteins (PMPs), binds PMPs in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane"
>YDL066W IDP1 SGDID:S000002224, Chr IV from 334835-336121, Verified ORF, "Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes"
>YDL067C COX9 SGDID:S000002225, Chr IV from 334396-334217, reverse complement, Verified ORF, "Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain"
>YDL068W YDL068W SGDID:S000002226, Chr IV from 333500-333829, Dubious ORF, "Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data"
>YDL069C CBS1 SGDID:S000002227, Chr IV from 333810-333121, reverse complement, Verified ORF, "Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader"
>YDL070W BDF2 SGDID:S000002228, Chr IV from 331024-332940, Verified ORF, "Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p"
>YDL071C YDL071C SGDID:S000002229, Chr IV from 331040-330666, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF BDF2/YDL070W"
>YDL072C YET3 SGDID:S000002230, Chr IV from 330447-329836, reverse complement, Verified ORF, "Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein"
>YDL073W YDL073W SGDID:S000002231, Chr IV from 326613-329567, Uncharacterized ORF, "Putative protein of unknown function; YDL073W is not an essential gene"
>YDL074C BRE1 SGDID:S000002232, Chr IV from 326149-324047, reverse complement, Verified ORF, "E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control"
>YDL075W RPL31A SGDID:S000002233, Chr IV from 322226-322282,322704-322988, Verified ORF, "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Bp and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality"
>YDL076C RXT3 SGDID:S000002234, Chr IV from 321552-320668, reverse complement, Verified ORF, "Subunit of the RPD3L complex; involved in histone deacetylation"
>YDL077C VAM6 SGDID:S000002235, Chr IV from 320120-316971, reverse complement, Verified ORF, "Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p"
>YDL078C MDH3 SGDID:S000002236, Chr IV from 316388-315357, reverse complement, Verified ORF, "Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle"
>YDL079C MRK1 SGDID:S000002237, Chr IV from 314044-312951,314748-314337, reverse complement, Verified ORF, "Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation"
>YDL080C THI3 SGDID:S000002238, Chr IV from 312471-310642, reverse complement, Verified ORF, "Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis"
>YDL081C RPP1A SGDID:S000002239, Chr IV from 310122-309802, reverse complement, Verified ORF, "Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component"
>YDL082W RPL13A SGDID:S000002240, Chr IV from 308424-308427,308793-309388, Verified ORF, "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Bp; not essential for viability; has similarity to rat L13 ribosomal protein"
>YDL083C RPS16B SGDID:S000002241, Chr IV from 307333-306926,307789-307766, reverse complement, Verified ORF, "Protein component of the small (40S) ribosomal subunit; identical to Rps16Ap and has similarity to E. coli S9 and rat S16 ribosomal proteins"
>YDL084W SUB2 SGDID:S000002242, Chr IV from 305237-306577, Verified ORF, "Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56"
>YDL085C-A YDL085C-A SGDID:S000007588, Chr IV from 302670-302464, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus"
>YDL085W NDE2 SGDID:S000002243, Chr IV from 303211-304848, Verified ORF, "Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain"
>YDL086C-A YDL086C-A SGDID:S000028611, Chr IV from 302089-301655, reverse complement, Dubious ORF, "Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps uncharacterized ORF YDL086W; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching"
>YDL086W YDL086W SGDID:S000002244, Chr IV from 301413-302234, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene"
>YDL087C LUC7 SGDID:S000002245, Chr IV from 300999-300214, reverse complement, Verified ORF, "Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA"
>YDL088C ASM4 SGDID:S000002246, Chr IV from 300003-298417, reverse complement, Verified ORF, "Nuclear pore complex subunit, part of a subcomplex also containing Nup53p, Nup170p, and Pse1p"
>YDL089W NUR1 SGDID:S000002247, Chr IV from 296820-298274, Verified ORF, "Protein of unknown function; interacts with Csm1p, Lrs4p; required for rDNA repeat stability; null mutant causes increase in unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery, possible Cdc28p substrate"
>YDL090C RAM1 SGDID:S000002248, Chr IV from 296329-295034, reverse complement, Verified ORF, "Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit"
>YDL091C UBX3 SGDID:S000002249, Chr IV from 294759-293392, reverse complement, Verified ORF, "UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern"
>YDL092W SRP14 SGDID:S000002250, Chr IV from 292781-293221, Verified ORF, "Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14"
>YDL093W PMT5 SGDID:S000002251, Chr IV from 289909-292140, Verified ORF, "Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals"
>YDL094C YDL094C SGDID:S000002252, Chr IV from 290081-289572, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verfied gene PMT5/YDL093W; YDL094C is not essential"
>YDL095W PMT1 SGDID:S000002253, Chr IV from 287059-289512, Verified ORF, "Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein Ser/Thr residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control"
>YDL096C OPI6 SGDID:S000002254, Chr IV from 287324-286998, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential"
>YDL097C RPN6 SGDID:S000002255, Chr IV from 286695-285391, reverse complement, Verified ORF, "Essential, non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion"
>YDL098C SNU23 SGDID:S000002256, Chr IV from 285165-284581, reverse complement, Verified ORF, "Component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosome"
>YDL099W BUG1 SGDID:S000002257, Chr IV from 283419-284444, Verified ORF, "Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes"
>YDL100C GET3 SGDID:S000002258, Chr IV from 283176-282112, reverse complement, Verified ORF, "Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity"
>YDL101C DUN1 SGDID:S000002259, Chr IV from 281848-280307, reverse complement, Verified ORF, "Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair"
>YDL102W POL3 SGDID:S000002260, Chr IV from 276872-280165, Verified ORF, "Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)"
>YDL103C QRI1 SGDID:S000002261, Chr IV from 276581-275148, reverse complement, Verified ORF, "UDP-N-acetylglucosamine pyrophosphorylase, catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis"
>YDL104C QRI7 SGDID:S000002262, Chr IV from 274876-273653, reverse complement, Verified ORF, "Highly conserved mitochondrial protein, essential for stability of the mitochondrial genome; functional homolog of the essential E. coli ygjD gene; member of a family of proteins putatively involved in genome maintenance"
>YDL105W NSE4 SGDID:S000002263, Chr IV from 272389-273597, Verified ORF, "Nuclear protein that plays a role in the function of the Smc5p-Rhc18p complex"
>YDL106C PHO2 SGDID:S000002264, Chr IV from 271901-270222, reverse complement, Verified ORF, "Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p"
>YDL107W MSS2 SGDID:S000002265, Chr IV from 268921-269976, Verified ORF, "Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p"
>YDL108W KIN28 SGDID:S000002266, Chr IV from 267698-267725,267807-268699, Verified ORF, "Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters"
>YDL109C YDL109C SGDID:S000002267, Chr IV from 267201-265258, reverse complement, Uncharacterized ORF, "Putative lipase; involved in lipid metabolism; YDL109C is not an essential gene"
>YDL110C TMA17 SGDID:S000002268, Chr IV from 264964-264512, reverse complement, Verified ORF, "Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion"
>YDL111C RRP42 SGDID:S000002269, Chr IV from 264110-263313, reverse complement, Verified ORF, "Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)"
>YDL112W TRM3 SGDID:S000002270, Chr IV from 258915-263225, Verified ORF, "2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs"
>YDL113C ATG20 SGDID:S000002271, Chr IV from 258555-256633, reverse complement, Verified ORF, "Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate"
>YDL114W YDL114W SGDID:S000002272, Chr IV from 255604-256530, Uncharacterized ORF, "Putative protein of unknown function with similarity to acyl-carrier-protein reductases; YDL114W is not an essential gene"
>YDL114W-A YDL114W-A SGDID:S000007598, Chr IV from 254935-255048, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified based on homology to hemiascomycetous yeasts"
>YDL115C IWR1 SGDID:S000002273, Chr IV from 254974-253995,255126-255045, reverse complement, Verified ORF, "Protein involved in transcription from polymerase II promoters; interacts with with most of the polymerase II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to the K1 killer toxin"
>YDL116W NUP84 SGDID:S000002274, Chr IV from 251566-253746, Verified ORF, "Subunit of the nuclear pore complex (NPC), forms a subcomplex with Nup85p, Nup120p, Nup145p-C, Sec13p, and Seh1p that plays a role in nuclear mRNA export and NPC biogenesis"
>YDL117W CYK3 SGDID:S000002275, Chr IV from 248581-251238, Verified ORF, "SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring; mutant phenotype and genetic interactions suggest a role in cytokinesis"
>YDL118W YDL118W SGDID:S000002276, Chr IV from 247302-247682, Uncharacterized ORF, "Non-essential protein of unconfirmed function; mutants are defective in telomere maintenance, and are synthetically sick or lethal with alpha-synuclein"
>YDL119C YDL119C SGDID:S000002277, Chr IV from 247612-246689, reverse complement, Uncharacterized ORF, "Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria"
>YDL120W YFH1 SGDID:S000002278, Chr IV from 245923-246447, Verified ORF, "Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog is mutated in Friedrich's ataxia"
>YDL121C YDL121C SGDID:S000002279, Chr IV from 245582-245133, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein"
>YDL122W UBP1 SGDID:S000002280, Chr IV from 242552-244981, Verified ORF, "Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains"
>YDL123W SNA4 SGDID:S000002281, Chr IV from 241418-241840, Verified ORF, "Protein of unknown function, localized to the vacuolar outer membrane; predicted to be palmitoylated"
>YDL124W YDL124W SGDID:S000002282, Chr IV from 240259-241197, Verified ORF, "NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family"
>YDL125C HNT1 SGDID:S000002283, Chr IV from 239398-239019,239606-239510, reverse complement, Verified ORF, "Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint"
>YDL126C CDC48 SGDID:S000002284, Chr IV from 238664-236157, reverse complement, Verified ORF, "ATPase in ER, nuclear membrane and cytosol with homology to mammalian p97; in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasome"
>YDL127W PCL2 SGDID:S000002285, Chr IV from 234927-235853, Verified ORF, "Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth"
>YDL128W VCX1 SGDID:S000002286, Chr IV from 232652-233887, Verified ORF, "Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity, involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter"
>YDL129W YDL129W SGDID:S000002287, Chr IV from 231024-231899, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene"
>YDL130W RPP1B SGDID:S000002288, Chr IV from 229906-230019,230321-230527, Verified ORF, "Ribosomal protein P1 beta, component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; accumulation is regulated by phosphorylation and interaction with the P2 stalk component"
>YDL130W-A STF1 SGDID:S000007232, Chr IV from 229171-229431, Verified ORF, "Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein"
>YDL131W LYS21 SGDID:S000002289, Chr IV from 227393-228715, Verified ORF, "Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys20p"
>YDL132W CDC53 SGDID:S000002290, Chr IV from 224304-226751, Verified ORF, "Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation"
>YDL133C-A RPL41B SGDID:S000002293, Chr IV from 221801-221724, reverse complement, Verified ORF, "Ribosomal protein L47 of the large (60S) ribosomal subunit, identical to Rpl41Ap and has similarity to rat L41 ribosomal protein; comprised of only 25 amino acids; rpl41a rpl41b double null mutant is viable"
>YDL133W YDL133W SGDID:S000002291, Chr IV from 222427-223740, Uncharacterized ORF, "Putative protein of unknown function"
>YDL134C PPH21 SGDID:S000002292, Chr IV from 220771-219662, reverse complement, Verified ORF, "Catalytic subunit of protein phosphatase 2A (PP2A), functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis"
>YDL135C RDI1 SGDID:S000002294, Chr IV from 219288-218680, reverse complement, Verified ORF, "Rho GDP dissociation inhibitor involved in the localization and regulation of Cdc42p"
>YDL136W RPL35B SGDID:S000002295, Chr IV from 217600-217602,218008-218367, Verified ORF, "Protein component of the large (60S) ribosomal subunit, identical to Rpl35Ap and has similarity to rat L35 ribosomal protein"
>YDL137W ARF2 SGDID:S000002296, Chr IV from 216529-217074, Verified ORF, "ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; functionally interchangeable with Arf1p"
>YDL138W RGT2 SGDID:S000002297, Chr IV from 213351-215642, Verified ORF, "Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; highly similar to Snf3p"
>YDL139C SCM3 SGDID:S000002298, Chr IV from 212046-211375, reverse complement, Verified ORF, "Nonhistone component of centromeric chromatin that binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; required for G2/M progression and localization of Cse4p; may protect Cse4p from ubiquitylation"
>YDL140C RPO21 SGDID:S000002299, Chr IV from 210561-205360, reverse complement, Verified ORF, "RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime"
>YDL141W BPL1 SGDID:S000002300, Chr IV from 203039-205111, Verified ORF, "Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation"
>YDL142C CRD1 SGDID:S000002301, Chr IV from 202570-201719, reverse complement, Verified ORF, "Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function; also required for normal vacuolar ion homeostasis"
>YDL143W CCT4 SGDID:S000002302, Chr IV from 199996-201582, Verified ORF, "Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo"
>YDL144C YDL144C SGDID:S000002303, Chr IV from 199732-198662, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene."
>YDL145C COP1 SGDID:S000002304, Chr IV from 198176-194571, reverse complement, Verified ORF, "Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway"
>YDL146W LDB17 SGDID:S000002305, Chr IV from 192750-194225, Verified ORF, "Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck"
>YDL147W RPN5 SGDID:S000002306, Chr IV from 190924-192261, Verified ORF, "Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p"
>YDL148C NOP14 SGDID:S000002307, Chr IV from 190586-188154, reverse complement, Verified ORF, "Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA"
>YDL149W ATG9 SGDID:S000002308, Chr IV from 184925-187918, Verified ORF, "Transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between the phagophore assembly site (PAS) and other cytosolic punctate structures, not found in autophagosomes; may be involved in membrane delivery to the PAS"
>YDL150W RPC53 SGDID:S000002309, Chr IV from 183343-184611, Verified ORF, "RNA polymerase III subunit C53"
>YDL151C BUD30 SGDID:S000002310, Chr IV from 183899-183318, reverse complement, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay"
>YDL152W YDL152W SGDID:S000002311, Chr IV from 182822-183187, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome"
>YDL153C SAS10 SGDID:S000002312, Chr IV from 183018-181186, reverse complement, Verified ORF, "Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance"
>YDL154W MSH5 SGDID:S000002313, Chr IV from 178334-181039, Verified ORF, "Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans"
>YDL155W CLB3 SGDID:S000002314, Chr IV from 176773-178056, Verified ORF, "B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation"
>YDL156W YDL156W SGDID:S000002315, Chr IV from 174918-176486, Uncharacterized ORF, "Putative protein of unknown function; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus"
>YDL157C YDL157C SGDID:S000002316, Chr IV from 174588-174232, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YDL158C YDL158C SGDID:S000002317, Chr IV from 174174-173866, reverse complement, Dubious ORF, "Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data"
>YDL159C-B YDL159C-B SGDID:S000028612, Chr IV from 173232-173056, reverse complement, Dubious ORF, "Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YDL159W STE7 SGDID:S000002318, Chr IV from 172481-174028, Verified ORF, "Signal transducing MAP kinase kinase involved in pheromone response, where it phosphorylates Fus3p, and in the pseudohyphal/invasive growth pathway, through phosphorylation of Kss1p; phosphorylated by Ste11p, degraded by ubiquitin pathway"
>YDL159W-A YDL159W-A SGDID:S000007599, Chr IV from 172182-172313, Uncharacterized ORF, "Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species"
>YDL160C DHH1 SGDID:S000002319, Chr IV from 171930-170410, reverse complement, Verified ORF, "Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping, coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation"
>YDL160C-A YDL160C-A SGDID:S000028520, Chr IV from 169608-169366, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; mutant in a srs2 mutant background displays MMS hypersensitivity; ortholog of human MHF2, a component of the Fanconi anemia (FA) complex that is involved in maintaining genome stability"
>YDL161W ENT1 SGDID:S000002320, Chr IV from 167714-169078, Verified ORF, "Epsin-like protein involved in endocytosis and actin patch assembly and functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus"
>YDL162C YDL162C SGDID:S000002321, Chr IV from 167715-167359, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly"
>YDL163W YDL163W SGDID:S000002322, Chr IV from 166956-167258, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene CDC9/YDL164C encoding DNA ligase"
>YDL164C CDC9 SGDID:S000002323, Chr IV from 167254-164987, reverse complement, Verified ORF, "DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination"
>YDL165W CDC36 SGDID:S000002324, Chr IV from 164290-164865, Verified ORF, "Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor"
>YDL166C FAP7 SGDID:S000002325, Chr IV from 164042-163449, reverse complement, Verified ORF, "Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D"
>YDL167C NRP1 SGDID:S000002326, Chr IV from 163154-160995, reverse complement, Verified ORF, "Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis"
>YDL168W SFA1 SGDID:S000002327, Chr IV from 159604-160764, Verified ORF, "Bifunctional enzyme containing both alcohol dehydrogenase and glutathione-dependent formaldehyde dehydrogenase activities, functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p"
>YDL169C UGX2 SGDID:S000002328, Chr IV from 158735-158064, reverse complement, Verified ORF, "Protein of unknown function, transcript accumulates in response to any combination of stress conditions"
>YDL170W UGA3 SGDID:S000002329, Chr IV from 156318-157904, Verified ORF, "Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus"
>YDL171C GLT1 SGDID:S000002330, Chr IV from 155640-149203, reverse complement, Verified ORF, "NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source"
>YDL172C YDL172C SGDID:S000002331, Chr IV from 149086-148607, reverse complement, Dubious ORF, "Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data"
>YDL173W PAR32 SGDID:S000002332, Chr IV from 148191-149078, Verified ORF, "Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene"
>YDL174C DLD1 SGDID:S000002333, Chr IV from 147589-145826, reverse complement, Verified ORF, "D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane"
>YDL175C AIR2 SGDID:S000002334, Chr IV from 145518-144484, reverse complement, Verified ORF, "Zinc knuckle protein, involved in nuclear RNA processing and degredation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; functionally redundant with Air1p"
>YDL176W YDL176W SGDID:S000002335, Chr IV from 142097-144223, Verified ORF, "Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene"
>YDL177C YDL177C SGDID:S000002336, Chr IV from 141721-141209, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene"
>YDL178W DLD2 SGDID:S000002337, Chr IV from 139522-141114, Verified ORF, "D-lactate dehydrogenase, located in the mitochondrial matrix"
>YDL179W PCL9 SGDID:S000002338, Chr IV from 138291-139205, Verified ORF, "Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p"
>YDL180W YDL180W SGDID:S000002339, Chr IV from 135896-137539, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole"
>YDL181W INH1 SGDID:S000002340, Chr IV from 135179-135436, Verified ORF, "Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p; has a calmodulin-binding motif and binds calmodulin in vitro"
>YDL182W LYS20 SGDID:S000002341, Chr IV from 133437-134723, Verified ORF, "Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p"
>YDL183C YDL183C SGDID:S000002342, Chr IV from 131833-130871, reverse complement, Verified ORF, "Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene"
>YDL184C RPL41A SGDID:S000002343, Chr IV from 130484-130407, reverse complement, Verified ORF, "Ribosomal protein L47 of the large (60S) ribosomal subunit, identical to Rpl41Bp and has similarity to rat L41 ribosomal protein; comprised of only 25 amino acids; rpl41a rpl41b double null mutant is viable"
>YDL185C-A YDL185C-A SGDID:S000007600, Chr IV from 126835-126608, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDL185W; identified by homology with hemiascomycetous yeast species"
>YDL185W VMA1 SGDID:S000002344, Chr IV from 126787-130002, Verified ORF, "Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease"
>YDL186W YDL186W SGDID:S000002345, Chr IV from 125616-126449, Uncharacterized ORF, "Putative protein of unknown function; YDL186W is not an essential gene"
>YDL187C YDL187C SGDID:S000002346, Chr IV from 125838-125509, reverse complement, Dubious ORF, "Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YDL188C PPH22 SGDID:S000002347, Chr IV from 124998-123865, reverse complement, Verified ORF, "Catalytic subunit of protein phosphatase 2A (PP2A), functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis"
>YDL189W RBS1 SGDID:S000002348, Chr IV from 122216-123589, Verified ORF, "Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain"
>YDL190C UFD2 SGDID:S000002349, Chr IV from 121592-118707, reverse complement, Verified ORF, "Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3"
>YDL191W RPL35A SGDID:S000002350, Chr IV from 117664-117666,118158-118517, Verified ORF, "Protein component of the large (60S) ribosomal subunit, identical to Rpl35Bp and has similarity to rat L35 ribosomal protein"
>YDL192W ARF1 SGDID:S000002351, Chr IV from 116321-116866, Verified ORF, "ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p"
>YDL193W NUS1 SGDID:S000002352, Chr IV from 114672-115799, Verified ORF, "Putative prenyltransferase, required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY"
>YDL194W SNF3 SGDID:S000002353, Chr IV from 111580-114234, Verified ORF, "Plasma membrane low glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; similar to Rgt2p"
>YDL195W SEC31 SGDID:S000002354, Chr IV from 107208-111029, Verified ORF, "Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance"
>YDL196W YDL196W SGDID:S000002355, Chr IV from 106741-107070, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31"
>YDL197C ASF2 SGDID:S000002356, Chr IV from 106494-104917, reverse complement, Verified ORF, "Anti-silencing protein that causes derepression of silent loci when overexpressed"
>YDL198C GGC1 SGDID:S000002357, Chr IV from 104551-103649, reverse complement, Verified ORF, "Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family"
>YDL199C YDL199C SGDID:S000002358, Chr IV from 103353-101290, reverse complement, Uncharacterized ORF, "Putative transporter, member of the sugar porter family"
>YDL200C MGT1 SGDID:S000002359, Chr IV from 101067-100501, reverse complement, Verified ORF, "DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage"
>YDL201W TRM8 SGDID:S000002360, Chr IV from 99561-100421, Verified ORF, "Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA"
>YDL202W MRPL11 SGDID:S000002361, Chr IV from 98475-99224, Verified ORF, "Mitochondrial ribosomal protein of the large subunit"
>YDL203C ACK1 SGDID:S000002362, Chr IV from 97953-96082, reverse complement, Verified ORF, "Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria"
>YDL204W RTN2 SGDID:S000002363, Chr IV from 94605-95786, Verified ORF, "Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily"
>YDL205C HEM3 SGDID:S000002364, Chr IV from 93745-92762, reverse complement, Verified ORF, "Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme"
>YDL206W YDL206W SGDID:S000002365, Chr IV from 90176-92464, Uncharacterized ORF, "Putative protein of unknown function; YDL206W is not an essential protein"
>YDL207W GLE1 SGDID:S000002366, Chr IV from 88248-89864, Verified ORF, "Cytoplasmic nucleoporin required for polyadenylated RNA export but not for protein import; component of Nup82p nuclear pore subcomplex; contains a nuclear export signal"
>YDL208W NHP2 SGDID:S000002367, Chr IV from 87512-87982, Verified ORF, "Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing"
>YDL209C CWC2 SGDID:S000002368, Chr IV from 87226-86207, reverse complement, Verified ORF, "Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2"
>YDL210W UGA4 SGDID:S000002369, Chr IV from 84270-85985, Verified ORF, "Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane"
>YDL211C YDL211C SGDID:S000002370, Chr IV from 80412-79294, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole"
>YDL212W SHR3 SGDID:S000002371, Chr IV from 78426-79058, Verified ORF, "Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface"
>YDL213C NOP6 SGDID:S000002372, Chr IV from 77966-77289, reverse complement, Verified ORF, "Putative RNA-binding protein implicated in ribosome biogenesis; contains an RNA recognition motif (RRM) and has similarity to hydrophilins; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes"
>YDL214C PRR2 SGDID:S000002373, Chr IV from 76545-74446, reverse complement, Verified ORF, "Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance"
>YDL215C GDH2 SGDID:S000002374, Chr IV from 73918-70640, reverse complement, Verified ORF, "NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels"
>YDL216C RRI1 SGDID:S000002375, Chr IV from 70319-68997, reverse complement, Verified ORF, "Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling"
>YDL217C TIM22 SGDID:S000002376, Chr IV from 68606-67983, reverse complement, Verified ORF, "Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported"
>YDL218W YDL218W SGDID:S000002377, Chr IV from 66493-67446, Uncharacterized ORF, "Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin"
>YDL219W DTD1 SGDID:S000002378, Chr IV from 65242-65306,65378-65765, Verified ORF, "D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes"
>YDL220C CDC13 SGDID:S000002379, Chr IV from 65018-62244, reverse complement, Verified ORF, "Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping"
>YDL221W YDL221W SGDID:S000002380, Chr IV from 62011-62562, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13"
>YDL222C FMP45 SGDID:S000002381, Chr IV from 61801-60872, reverse complement, Verified ORF, "Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C"
>YDL223C HBT1 SGDID:S000002382, Chr IV from 60405-57265, reverse complement, Verified ORF, "Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis"
>YDL224C WHI4 SGDID:S000002383, Chr IV from 56346-54397, reverse complement, Verified ORF, "Putative RNA binding protein and partially redundant Whi3p homolog that regulates the cell size requirement for passage through Start and commitment to cell division"
>YDL225W SHS1 SGDID:S000002384, Chr IV from 52445-54100, Verified ORF, "One of five related septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p, Shs1p) that form a cortical filamentous collar at the mother-bud neck which is necessary for normal morphogenesis and cytokinesis"
>YDL226C GCS1 SGDID:S000002385, Chr IV from 52173-51115, reverse complement, Verified ORF, "ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p"
>YDL227C HO SGDID:S000002386, Chr IV from 48031-46271, reverse complement, Verified ORF, "Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p"
>YDL228C YDL228C SGDID:S000002387, Chr IV from 45918-45277, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene SSB1"
>YDL229W SSB1 SGDID:S000002388, Chr IV from 44065-45906, Verified ORF, "Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p"
>YDL230W PTP1 SGDID:S000002389, Chr IV from 42700-43707, Verified ORF, "Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria"
>YDL231C BRE4 SGDID:S000002390, Chr IV from 42244-38867, reverse complement, Verified ORF, "Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport"
>YDL232W OST4 SGDID:S000002391, Chr IV from 38487-38597, Verified ORF, "Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes protein asparagine-linked glycosylation; type I membrane protein required for incorporation of Ost3p or Ost6p into the OST complex"
>YDL233W YDL233W SGDID:S000002392, Chr IV from 36797-38173, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL233W is not an essential gene"
>YDL234C GYP7 SGDID:S000002393, Chr IV from 36477-34237, reverse complement, Verified ORF, "GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking"
>YDL235C YPD1 SGDID:S000002394, Chr IV from 33918-33415, reverse complement, Verified ORF, "Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus"
>YDL236W PHO13 SGDID:S000002395, Chr IV from 32296-33234, Verified ORF, "Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity"
>YDL237W AIM6 SGDID:S000002396, Chr IV from 30657-31829, Verified ORF, "Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene"
>YDL238C GUD1 SGDID:S000002397, Chr IV from 30454-28985, reverse complement, Verified ORF, "Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures"
>YDL239C ADY3 SGDID:S000002398, Chr IV from 28775-26403, reverse complement, Verified ORF, "Protein required for spore wall formation, thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p"
>YDL240C-A YDL240C-A SGDID:S000007601, Chr IV from 22608-22471, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by sequence comparison with hemiascomycetous yeast species"
>YDL240W LRG1 SGDID:S000002399, Chr IV from 22823-25876, Verified ORF, "Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis"
>YDL241W YDL241W SGDID:S000002400, Chr IV from 20635-21006, Uncharacterized ORF, "Putative protein of unknown function; YDL241W is not an essential gene"
>YDL242W YDL242W SGDID:S000002401, Chr IV from 18959-19312, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YDL243C AAD4 SGDID:S000002402, Chr IV from 18566-17577, reverse complement, Verified ORF, "Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase, involved in the oxidative stress response; expression induced in cells treated with the mycotoxin patulin"
>YDL244W THI13 SGDID:S000002403, Chr IV from 16204-17226, Verified ORF, "Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13"
>YDL245C HXT15 SGDID:S000002404, Chr IV from 13360-11657, reverse complement, Verified ORF, "Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose"
>YDL246C SOR2 SGDID:S000002405, Chr IV from 9756-8683, reverse complement, Uncharacterized ORF, "Protein of unknown function; protein sequence is 99% identical to the Sor1p sorbitol dehydrogenase; computational analysis of large-scale protein-protein interaction data also suggests a role in fructose or mannose metabolism"
>YDL247W MPH2 SGDID:S000002406, Chr IV from 5985-7814, Verified ORF, "Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph3p; encoded in a subtelomeric position in a region likely to have undergone duplication"
>YDL247W-A YDL247W-A SGDID:S000007602, Chr IV from 3762-3836, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by sequence comparison with hemiascomycetous yeast species"
>YDL248W COS7 SGDID:S000002407, Chr IV from 1802-2953, Verified ORF, "Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YDR001C NTH1 SGDID:S000002408, Chr IV from 452475-450220, reverse complement, Verified ORF, "Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p"
>YDR002W YRB1 SGDID:S000002409, Chr IV from 453045-453650, Verified ORF, "Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1"
>YDR003W RCR2 SGDID:S000002410, Chr IV from 454122-454754, Verified ORF, "Vacuolar protein that presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; similar to Rcr1p"
>YDR003W-A YDR003W-A SGDID:S000028819, Chr IV from 454782-454904, Uncharacterized ORF, "Putative protein of unknown function; identified by expression profiling and mass spectrometry"
>YDR004W RAD57 SGDID:S000002411, Chr IV from 455201-456583, Verified ORF, "Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p"
>YDR005C MAF1 SGDID:S000002412, Chr IV from 458017-456836,458103-458098, reverse complement, Verified ORF, "Negative regulator of RNA polymerase III; component of several signaling pathways that repress polymerase III transcription in response to changes in cellular environment; targets the initiation factor TFIIIB"
>YDR006C SOK1 SGDID:S000002413, Chr IV from 461247-458542, reverse complement, Verified ORF, "Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13"
>YDR007W TRP1 SGDID:S000002414, Chr IV from 461842-462516, Verified ORF, "Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)"
>YDR008C YDR008C SGDID:S000002415, Chr IV from 462602-462252, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YDR009W GAL3 SGDID:S000002416, Chr IV from 463434-464996, Verified ORF, "Transcriptional regulator involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity"
>YDR010C YDR010C SGDID:S000002417, Chr IV from 465383-465051, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YDR011W SNQ2 SGDID:S000002418, Chr IV from 465919-470424, Verified ORF, "Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species"
>YDR012W RPL4B SGDID:S000002419, Chr IV from 471853-472941, Verified ORF, "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Ap and has similarity to E. coli L4 and rat L4 ribosomal proteins"
>YDR013W PSF1 SGDID:S000002420, Chr IV from 473157-473783, Verified ORF, "Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery"
>YDR014W RAD61 SGDID:S000002421, Chr IV from 474046-475989, Verified ORF, "Subunit of a complex (Scc3p, Pds5p, Rad61p) that inhibits sister chromatid cohesion; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; related to the human Wapl protein that controls the association of cohesin with chromatin"
>YDR014W-A HED1 SGDID:S000113613, Chr IV from 477797-478285, Verified ORF, "Meiosis-specific protein that down-regulates Rad51p-mediated mitotic recombination when the meiotic recombination machinery is impaired; early meiotic gene, transcribed specifically during meiotic prophase"
>YDR015C YDR015C SGDID:S000002422, Chr IV from 478199-477960, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HED1/YDR014W-A"
>YDR016C DAD1 SGDID:S000002423, Chr IV from 478758-478474, reverse complement, Verified ORF, "Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis"
>YDR017C KCS1 SGDID:S000002424, Chr IV from 482267-479115, reverse complement, Verified ORF, "Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance"
>YDR018C YDR018C SGDID:S000002425, Chr IV from 483860-482670, reverse complement, Uncharacterized ORF, "Probable membrane protein with three predicted transmembrane domains; homologous to Ybr042cp, similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase"
>YDR019C GCV1 SGDID:S000002426, Chr IV from 485365-484163, reverse complement, Verified ORF, "T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm"
>YDR020C DAS2 SGDID:S000002427, Chr IV from 486444-485746, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases"
>YDR021W FAL1 SGDID:S000002428, Chr IV from 486804-488003, Verified ORF, "Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases"
>YDR022C CIS1 SGDID:S000002429, Chr IV from 488662-488072, reverse complement, Verified ORF, "Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion"
>YDR023W SES1 SGDID:S000002430, Chr IV from 489508-490896, Verified ORF, "Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p"
>YDR024W FYV1 SGDID:S000002431, Chr IV from 491017-491502, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin"
>YDR025W RPS11A SGDID:S000002432, Chr IV from 491515-491559,491899-492324, Verified ORF, "Protein component of the small (40S) ribosomal subunit; identical to Rps11Bp and has similarity to E. coli S17 and rat S11 ribosomal proteins"
>YDR026C YDR026C SGDID:S000002433, Chr IV from 494268-492556, reverse complement, Verified ORF, "Protein of unknown function that may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein that may bind to the Ter region of rDNA; interacts physically with Fob1p"
>YDR027C VPS54 SGDID:S000002434, Chr IV from 497318-494649, reverse complement, Verified ORF, "Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; potentially phosphorylated by Cdc28p"
>YDR028C REG1 SGDID:S000002435, Chr IV from 500879-497835, reverse complement, Verified ORF, "Regulatory subunit of type 1 protein phosphatase Glc7p, involved in negative regulation of glucose-repressible genes"
>YDR029W YDR029W SGDID:S000002436, Chr IV from 501100-501414, Dubious ORF, "Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data"
>YDR030C RAD28 SGDID:S000002437, Chr IV from 503273-501753, reverse complement, Verified ORF, "Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair"
>YDR031W MIC14 SGDID:S000002438, Chr IV from 503498-503863, Verified ORF, "Mitochondrial intermembrane space protein, required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs"
>YDR032C PST2 SGDID:S000002439, Chr IV from 504695-504099, reverse complement, Verified ORF, "Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YDR033W MRH1 SGDID:S000002440, Chr IV from 508147-509109, Verified ORF, "Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p"
>YDR034C LYS14 SGDID:S000002441, Chr IV from 512109-509737, reverse complement, Verified ORF, "Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer"
>YDR034C-A YDR034C-A SGDID:S000007233, Chr IV from 520692-520516, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; contained within the solo Ty1 LTR element YDRWdelta7"
>YDR034C-C YDR034C-C SGDID:S000007344, Chr IV from 519356-518040, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YDR034C-D YDR034C-D SGDID:S000007345, Chr IV from 518062-514043,519356-518064, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YDR034W-B YDR034W-B SGDID:S000007234, Chr IV from 521314-521469, Uncharacterized ORF, "Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery"
>YDR035W ARO3 SGDID:S000002442, Chr IV from 521816-522928, Verified ORF, "3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan"
>YDR036C EHD3 SGDID:S000002443, Chr IV from 524713-523211, reverse complement, Verified ORF, "3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis"
>YDR037W KRS1 SGDID:S000002444, Chr IV from 525440-527215, Verified ORF, "Lysyl-tRNA synthetase"
>YDR038C ENA5 SGDID:S000002445, Chr IV from 530697-527422, reverse complement, Verified ORF, "Protein with similarity to P-type ATPase sodium pumps, member of the Na+ efflux ATPase family"
>YDR039C ENA2 SGDID:S000002446, Chr IV from 534582-531307, reverse complement, Verified ORF, "P-type ATPase sodium pump, involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux"
>YDR040C ENA1 SGDID:S000002447, Chr IV from 538467-535192, reverse complement, Verified ORF, "P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance"
>YDR041W RSM10 SGDID:S000002448, Chr IV from 539803-540414, Verified ORF, "Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins"
>YDR042C YDR042C SGDID:S000002449, Chr IV from 541203-540601, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; expression is increased in ssu72-ts69 mutant"
>YDR043C NRG1 SGDID:S000002450, Chr IV from 543369-542674, reverse complement, Verified ORF, "Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response"
>YDR044W HEM13 SGDID:S000002451, Chr IV from 546642-547628, Verified ORF, "Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)"
>YDR045C RPC11 SGDID:S000002452, Chr IV from 548310-547978, reverse complement, Verified ORF, "RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS"
>YDR046C BAP3 SGDID:S000002453, Chr IV from 550576-548762, reverse complement, Verified ORF, "Amino acid permease involved in the uptake of cysteine, leucine, isoleucine and valine"
>YDR047W HEM12 SGDID:S000002454, Chr IV from 551860-552948, Verified ORF, "Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda"
>YDR048C YDR048C SGDID:S000002455, Chr IV from 553398-553084, reverse complement, Dubious ORF, "Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YDR049W VMS1 SGDID:S000002456, Chr IV from 553254-555152, Uncharacterized ORF, "Zinc finger protein; putative transcription factor that may interact with proteins involved in histone acetylation or deacetylation; may be involved in altering acetylation on histone lysines"
>YDR050C TPI1 SGDID:S000002457, Chr IV from 556472-555726, reverse complement, Verified ORF, "Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region"
>YDR051C DET1 SGDID:S000002458, Chr IV from 558060-557056, reverse complement, Verified ORF, "Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel"
>YDR052C DBF4 SGDID:S000002459, Chr IV from 560625-558511, reverse complement, Verified ORF, "Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated"
>YDR053W YDR053W SGDID:S000002460, Chr IV from 560249-560644, Dubious ORF, "Putative protein of unknown function; open reading frame overlaps 5' end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex"
>YDR054C CDC34 SGDID:S000002461, Chr IV from 562327-561440, reverse complement, Verified ORF, "Ubiquitin-conjugating enzyme (E2) and catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation"
>YDR055W PST1 SGDID:S000002462, Chr IV from 563527-564861, Verified ORF, "Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1"
>YDR056C YDR056C SGDID:S000002463, Chr IV from 565640-565023, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein"
>YDR057W YOS9 SGDID:S000002464, Chr IV from 565927-567555, Verified ORF, "ER quality-control lectin; integral subunit of the HRD ligase; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family"
>YDR058C TGL2 SGDID:S000002465, Chr IV from 568703-567723, reverse complement, Verified ORF, "Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli"
>YDR059C UBC5 SGDID:S000002466, Chr IV from 569633-569234,569770-569724, reverse complement, Verified ORF, "Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible"
>YDR060W MAK21 SGDID:S000002467, Chr IV from 570649-573726, Verified ORF, "Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein"
>YDR061W YDR061W SGDID:S000002468, Chr IV from 574164-575783, Uncharacterized ORF, "Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance"
>YDR062W LCB2 SGDID:S000002469, Chr IV from 576474-578159, Verified ORF, "Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine"
>YDR063W AIM7 SGDID:S000002470, Chr IV from 578663-579112, Verified ORF, "Protein that interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss"
>YDR064W RPS13 SGDID:S000002471, Chr IV from 579458-579478,580018-580452, Verified ORF, "Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S15 and rat S13 ribosomal proteins"
>YDR065W RRG1 SGDID:S000002472, Chr IV from 580687-581784, Verified ORF, "Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YDR066C RTR2 SGDID:S000002473, Chr IV from 582498-581908, reverse complement, Uncharacterized ORF, "Protein of unknown function with high similarity to Rtr1p; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene"
>YDR067C OCA6 SGDID:S000002474, Chr IV from 583465-582791, reverse complement, Uncharacterized ORF, "Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT"
>YDR068W DOS2 SGDID:S000002475, Chr IV from 583713-584645, Verified ORF, "Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"
>YDR069C DOA4 SGDID:S000002476, Chr IV from 587719-584939, reverse complement, Verified ORF, "Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole"
>YDR070C FMP16 SGDID:S000002477, Chr IV from 588379-588098, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; proposed to be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YDR071C PAA1 SGDID:S000002478, Chr IV from 589402-588827, reverse complement, Verified ORF, "Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication"
>YDR072C IPT1 SGDID:S000002479, Chr IV from 591344-589761, reverse complement, Verified ORF, "Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid;, can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin"
>YDR073W SNF11 SGDID:S000002480, Chr IV from 592439-592948, Verified ORF, "Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p"
>YDR074W TPS2 SGDID:S000002481, Chr IV from 593893-596583, Verified ORF, "Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway"
>YDR075W PPH3 SGDID:S000002482, Chr IV from 597156-598082, Verified ORF, "Catalytic subunit of an evolutionarily conserved protein phosphatase complex containing Psy2p and the regulatory subunit Psy4p; required for cisplatin resistance; involved in activation of Gln3p"
>YDR076W RAD55 SGDID:S000002483, Chr IV from 598468-599688, Verified ORF, "Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p"
>YDR077W SED1 SGDID:S000002484, Chr IV from 600793-601809, Verified ORF, "Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites"
>YDR078C SHU2 SGDID:S000002485, Chr IV from 602869-602198, reverse complement, Verified ORF, "Protein involved in a Rad51p-, Rad54p-dependent pathway for homologous recombination repair, important for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation; associates with Shu1p, Psy3p, and Csm2p"
>YDR079C-A TFB5 SGDID:S000007603, Chr IV from 603811-603593, reverse complement, Verified ORF, "Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair"
>YDR079W PET100 SGDID:S000002486, Chr IV from 603064-603399, Verified ORF, "Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme"
>YDR080W VPS41 SGDID:S000002487, Chr IV from 604008-606986, Verified ORF, "Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport"
>YDR081C PDC2 SGDID:S000002488, Chr IV from 610081-607304, reverse complement, Verified ORF, "Transcription factor required for the synthesis of the glycolytic enzyme pyruvate decarboxylase, required for high level expression of both the THI and the PDC genes"
>YDR082W STN1 SGDID:S000002489, Chr IV from 610441-611925, Verified ORF, "Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping"
>YDR083W RRP8 SGDID:S000002490, Chr IV from 612073-613251, Verified ORF, "Nucleolar protein involved in rRNA processing, pre-rRNA cleavage at site A2; also involved in telomere maintenance; mutation is synthetically lethal with a gar1 mutation"
>YDR084C TVP23 SGDID:S000002491, Chr IV from 614004-613405, reverse complement, Verified ORF, "Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern"
>YDR085C AFR1 SGDID:S000002492, Chr IV from 616150-614288, reverse complement, Verified ORF, "Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p"
>YDR086C SSS1 SGDID:S000002493, Chr IV from 617170-616928, reverse complement, Verified ORF, "Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p"
>YDR087C RRP1 SGDID:S000002494, Chr IV from 618306-617470, reverse complement, Verified ORF, "Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles"
>YDR088C SLU7 SGDID:S000002495, Chr IV from 619645-618497, reverse complement, Verified ORF, "RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain"
>YDR089W YDR089W SGDID:S000002496, Chr IV from 622112-624721, Uncharacterized ORF, "Protein of unknown function; deletion confers resistance to Nickel"
>YDR090C YDR090C SGDID:S000002497, Chr IV from 625998-625066, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YDR091C RLI1 SGDID:S000002498, Chr IV from 628534-626708, reverse complement, Verified ORF, "Essential iron-sulfur protein required for ribosome biogenesis and translation initiation and termination; facilitates binding of a multifactor complex (MFC) of initiation factors to the small ribosomal subunit; predicted ABC family ATPase"
>YDR092W UBC13 SGDID:S000002499, Chr IV from 629876-629905,630174-630605, Verified ORF, "Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus"
>YDR093W DNF2 SGDID:S000002500, Chr IV from 631282-636120, Verified ORF, "Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase"
>YDR094W YDR094W SGDID:S000002501, Chr IV from 635840-636175, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2"
>YDR095C YDR095C SGDID:S000002502, Chr IV from 636527-636117, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YDR096W GIS1 SGDID:S000002503, Chr IV from 637139-639823, Verified ORF, "JmjC domain-containing histone demethylase; transcription factor involved in expression of genes during nutrient limitation and in negative regulation of DPP1 and PHR1; activity is modulated by limited proteasome-mediated proteolysis"
>YDR097C MSH6 SGDID:S000002504, Chr IV from 643837-640109, reverse complement, Verified ORF, "Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28p"
>YDR098C GRX3 SGDID:S000002505, Chr IV from 645035-644178, reverse complement, Verified ORF, "Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage"
>YDR098C-A YDR098C-A SGDID:S000007390, Chr IV from 651126-649804, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YDR098C-B YDR098C-B SGDID:S000007391, Chr IV from 649820-645858,651126-649822, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YDR099W BMH2 SGDID:S000002506, Chr IV from 653607-654428, Verified ORF, "14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling"
>YDR100W TVP15 SGDID:S000002507, Chr IV from 655013-655444, Verified ORF, "Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p"
>YDR101C ARX1 SGDID:S000002508, Chr IV from 657467-655686, reverse complement, Verified ORF, "Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex"
>YDR102C YDR102C SGDID:S000002509, Chr IV from 657980-657648, reverse complement, Dubious ORF, "Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index"
>YDR103W STE5 SGDID:S000002510, Chr IV from 658350-661103, Verified ORF, "Pheromone-response scaffold protein that controls the mating decision; binds Ste11p, Ste7p, and Fus3p kinases, forming a MAPK cascade complex that interacts with the plasma membrane and Ste4p-Ste18p; allosteric activator of Fus3p"
>YDR104C SPO71 SGDID:S000002511, Chr IV from 664910-661173, reverse complement, Verified ORF, "Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis"
>YDR105C TMS1 SGDID:S000002512, Chr IV from 666770-665349, reverse complement, Verified ORF, "Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance"
>YDR106W ARP10 SGDID:S000002513, Chr IV from 667004-667858, Verified ORF, "Component of the dynactin complex, localized to the pointed end of the Arp1p filament; may regulate membrane association of the complex"
>YDR107C TMN2 SGDID:S000002514, Chr IV from 671034-669016, reverse complement, Verified ORF, "Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments"
>YDR108W GSG1 SGDID:S000002515, Chr IV from 671269-673365, Verified ORF, "Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role"
>YDR109C YDR109C SGDID:S000002516, Chr IV from 675667-673520, reverse complement, Uncharacterized ORF, "Putative kinase"
>YDR110W FOB1 SGDID:S000002517, Chr IV from 676102-677802, Verified ORF, "Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases"
>YDR111C ALT2 SGDID:S000002518, Chr IV from 679764-678241, reverse complement, Uncharacterized ORF, "Putative alanine transaminase (glutamic pyruvic transaminase)"
>YDR112W IRC2 SGDID:S000002519, Chr IV from 679544-679852, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci"
>YDR113C PDS1 SGDID:S000002520, Chr IV from 681617-680496, reverse complement, Verified ORF, "Securin, inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation"
>YDR114C YDR114C SGDID:S000002521, Chr IV from 682226-681924, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium"
>YDR115W YDR115W SGDID:S000002522, Chr IV from 682175-682492, Uncharacterized ORF, "Putative mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins"
>YDR116C MRPL1 SGDID:S000002523, Chr IV from 683581-682724, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the large subunit"
>YDR117C TMA64 SGDID:S000002524, Chr IV from 685643-683946, reverse complement, Verified ORF, "Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity"
>YDR118W APC4 SGDID:S000002525, Chr IV from 685882-687840, Verified ORF, "Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition"
>YDR118W-A YDR118W-A SGDID:S000028820, Chr IV from 687768-687884, Dubious ORF, "Dubious open reading frame; identified using a combination of expression profiling and mass spectrometry"
>YDR119W VBA4 SGDID:S000002526, Chr IV from 688227-690533, Uncharacterized ORF, "Protein of unknown function with proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene"
>YDR119W-A YDR119W-A SGDID:S000113555, Chr IV from 691014-691214, Uncharacterized ORF, "Putative protein of unknown function; may interact with respiratory chain complexes III (ubiquinol-cytochrome c reductase) or IV (cytochrome c oxidase)"
>YDR120C TRM1 SGDID:S000002527, Chr IV from 693261-691549, reverse complement, Verified ORF, "tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments"
>YDR121W DPB4 SGDID:S000002528, Chr IV from 693585-694175, Verified ORF, "Shared subunit of DNA polymerase (II) epsilon and of ISW2/yCHRAC chromatin accessibility complex; involved in both chromosomal DNA replication and in inheritance of telomeric silencing"
>YDR122W KIN1 SGDID:S000002529, Chr IV from 694700-697894, Verified ORF, "Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p"
>YDR123C INO2 SGDID:S000002530, Chr IV from 699468-698554, reverse complement, Verified ORF, "Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion"
>YDR124W YDR124W SGDID:S000002531, Chr IV from 700315-701289, Uncharacterized ORF, "Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor"
>YDR125C ECM18 SGDID:S000002532, Chr IV from 702758-701397, reverse complement, Verified ORF, "Protein of unknown function, similar to Rlp24p"
>YDR126W SWF1 SGDID:S000002533, Chr IV from 703234-704244, Verified ORF, "Palmitoyltransferase that acts on the SNAREs Snc1p, Syn8p, Tlg1p and likely on all SNAREs; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion"
>YDR127W ARO1 SGDID:S000002534, Chr IV from 704484-709250, Verified ORF, "Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids"
>YDR128W MTC5 SGDID:S000002535, Chr IV from 709549-712995, Verified ORF, "Protein of unknown function; mtc5 is synthetically sick with cdc13-1"
>YDR129C SAC6 SGDID:S000002536, Chr IV from 715247-713340,715379-715359, reverse complement, Verified ORF, "Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton"
>YDR130C FIN1 SGDID:S000002537, Chr IV from 716622-715747, reverse complement, Verified ORF, "Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in mother and daughter cells; localization cell-cycle dependent; involved in Glc7p localization and regulation"
>YDR131C YDR131C SGDID:S000002538, Chr IV from 718460-716790, reverse complement, Uncharacterized ORF, "F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex"
>YDR132C YDR132C SGDID:S000002539, Chr IV from 720303-718816, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YDR133C YDR133C SGDID:S000002540, Chr IV from 721297-720962, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C"
>YDR134C YDR134C SGDID:S000002541, Chr IV from 721481-721071, reverse complement, pseudogene, "Hypothetical protein"
>YDR135C YCF1 SGDID:S000002542, Chr IV from 727551-723004, reverse complement, Verified ORF, "Vacuolar glutathione S-conjugate transporter of the ATP-binding cassette family, has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin; similar to human cystic fibrosis protein CFTR"
>YDR136C VPS61 SGDID:S000002543, Chr IV from 728283-727711, reverse complement, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect"
>YDR137W RGP1 SGDID:S000002544, Chr IV from 728259-730250, Verified ORF, "Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p"
>YDR138W HPR1 SGDID:S000002545, Chr IV from 730578-732836, Verified ORF, "Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p"
>YDR139C RUB1 SGDID:S000002546, Chr IV from 733702-733618,733924-733776, reverse complement, Verified ORF, "Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)"
>YDR140W MTQ2 SGDID:S000002547, Chr IV from 734138-734803, Verified ORF, "S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC"
>YDR141C DOP1 SGDID:S000002548, Chr IV from 739997-734901, reverse complement, Verified ORF, "Golgi-localized, leucine-zipper domain containing protein; involved in endosome to Golgi transport, organization of the ER, establishing cell polarity, and morphogenesis; detected in highly purified mitochondria in high-throughput studies"
>YDR142C PEX7 SGDID:S000002549, Chr IV from 741600-740473, reverse complement, Verified ORF, "Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP)"
>YDR143C SAN1 SGDID:S000002550, Chr IV from 743874-742042, reverse complement, Verified ORF, "Ubiquitin-protein ligase, involved in the proteasome-dependent degradation of aberrant nuclear proteins; contains intrinsically disordered regions that contribute to substrate recognition"
>YDR144C MKC7 SGDID:S000002551, Chr IV from 746101-744311, reverse complement, Verified ORF, "GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p"
>YDR145W TAF12 SGDID:S000002552, Chr IV from 746738-748357, Verified ORF, "Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A"
>YDR146C SWI5 SGDID:S000002553, Chr IV from 750742-748613, reverse complement, Verified ORF, "Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase"
>YDR147W EKI1 SGDID:S000002554, Chr IV from 751631-753235, Verified ORF, "Ethanolamine kinase, primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway"
>YDR148C KGD2 SGDID:S000002555, Chr IV from 755066-753675, reverse complement, Verified ORF, "Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated"
>YDR149C YDR149C SGDID:S000002556, Chr IV from 756262-755555, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth"
>YDR150W NUM1 SGDID:S000002557, Chr IV from 755628-763874, Verified ORF, "Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex"
>YDR151C CTH1 SGDID:S000002558, Chr IV from 765155-764178, reverse complement, Verified ORF, "Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis"
>YDR152W GIR2 SGDID:S000002559, Chr IV from 765706-766503, Verified ORF, "Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein"
>YDR153C ENT5 SGDID:S000002560, Chr IV from 767971-766736, reverse complement, Verified ORF, "Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin"
>YDR154C YDR154C SGDID:S000002561, Chr IV from 768753-768403, reverse complement, Dubious ORF, "Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein"
>YDR155C CPR1 SGDID:S000002562, Chr IV from 769000-768512, reverse complement, Verified ORF, "Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A"
>YDR156W RPA14 SGDID:S000002563, Chr IV from 769525-769938, Verified ORF, "RNA polymerase I subunit A14"
>YDR157W YDR157W SGDID:S000002564, Chr IV from 769931-770332, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YDR158W HOM2 SGDID:S000002565, Chr IV from 770357-771454, Verified ORF, "Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis"
>YDR159W SAC3 SGDID:S000002566, Chr IV from 771877-775782, Verified ORF, "Nuclear pore-associated protein, required for biogenesis of the small ribosomal subunit; forms a complex with Thp1p that is involved in transcription and in mRNA export from the nucleus"
>YDR160W SSY1 SGDID:S000002567, Chr IV from 776163-778721, Verified ORF, "Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes"
>YDR161W YDR161W SGDID:S000002568, Chr IV from 779043-780206, Uncharacterized ORF, "Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation; genetic interactions suggest a role in ER-associated protein degradation (ERAD)"
>YDR162C NBP2 SGDID:S000002569, Chr IV from 781100-780390, reverse complement, Verified ORF, "Protein involved in the HOG (high osmolarity glycerol) pathway, negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex, found in the nucleus and cytoplasm, contains an SH3 domain that binds Pbs2p"
>YDR163W CWC15 SGDID:S000002570, Chr IV from 781423-781950, Verified ORF, "Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p"
>YDR164C SEC1 SGDID:S000002571, Chr IV from 784215-782041, reverse complement, Verified ORF, "Sm-like protein involved in docking and fusion of exocytic vesicles through binding to assembled SNARE complexes at the membrane; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function"
>YDR165W TRM82 SGDID:S000002572, Chr IV from 784871-786205, Verified ORF, "Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA"
>YDR166C SEC5 SGDID:S000002573, Chr IV from 789221-786306, reverse complement, Verified ORF, "Essential 107kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis"
>YDR167W TAF10 SGDID:S000002574, Chr IV from 789449-790069, Verified ORF, "Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification"
>YDR168W CDC37 SGDID:S000002575, Chr IV from 790328-791848, Verified ORF, "Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding"
>YDR169C STB3 SGDID:S000002576, Chr IV from 793889-792348, reverse complement, Verified ORF, "Ribosomal RNA processing element (RRPE)-binding protein involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p"
>YDR169C-A YDR169C-A SGDID:S000028538, Chr IV from 794723-794574, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by fungal homology and RT-PCR"
>YDR170C SEC7 SGDID:S000002577, Chr IV from 802222-796193, reverse complement, Verified ORF, "Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles"
>YDR170W-A YDR170W-A SGDID:S000007227, Chr IV from 803195-804517, transposable_element_gene, "Retrotransposon TYA Gag gene; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag; YDR170W-A is part of a mutant retrotransposon"
>YDR171W HSP42 SGDID:S000002578, Chr IV from 806621-807748, Verified ORF, "Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock"
>YDR172W SUP35 SGDID:S000002579, Chr IV from 808324-810381, Verified ORF, "Translation termination factor eRF3; altered protein conformation creates the [PSI(+)] prion, a dominant cytoplasmically inherited protein aggregate that alters translational fidelity and creates a nonsense suppressor phenotype"
>YDR173C ARG82 SGDID:S000002580, Chr IV from 811632-810565, reverse complement, Verified ORF, "Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes"
>YDR174W HMO1 SGDID:S000002581, Chr IV from 812110-812850, Verified ORF, "Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase"
>YDR175C RSM24 SGDID:S000002582, Chr IV from 814152-813193, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the small subunit"
>YDR176W NGG1 SGDID:S000002583, Chr IV from 814452-816560, Verified ORF, "Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex"
>YDR177W UBC1 SGDID:S000002584, Chr IV from 816878-817525, Verified ORF, "Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response"
>YDR178W SDH4 SGDID:S000002585, Chr IV from 817950-818495, Verified ORF, "Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain"
>YDR179C CSN9 SGDID:S000002586, Chr IV from 819196-818708, reverse complement, Verified ORF, "Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling"
>YDR179W-A YDR179W-A SGDID:S000002587, Chr IV from 819433-820824, Uncharacterized ORF, "Putative protein of unknown function"
>YDR180W SCC2 SGDID:S000002588, Chr IV from 821295-825776, Verified ORF, "Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; evolutionarily-conserved adherin"
>YDR181C SAS4 SGDID:S000002589, Chr IV from 827355-825910, reverse complement, Verified ORF, "Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which  acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p"
>YDR182W CDC1 SGDID:S000002590, Chr IV from 827582-829057, Verified ORF, "Putative lipid phosphatase of the endoplasmic reticulum; shows Mn2+ dependence and may affect Ca2+ signaling; mutants display actin and general growth defects and pleiotropic defects in cell cycle progression and organelle distribution"
>YDR182W-A YDR182W-A SGDID:S000028539, Chr IV from 829151-829354, Uncharacterized ORF, "Putative protein of unknown function; identified by fungal homology and RT-PCR"
>YDR183C-A YDR183C-A SGDID:S000028540, Chr IV from 830654-830397, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR"
>YDR183W PLP1 SGDID:S000002591, Chr IV from 829585-830277, Verified ORF, "Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators"
>YDR184C ATC1 SGDID:S000002592, Chr IV from 831513-830629, reverse complement, Verified ORF, "Nuclear protein, possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern"
>YDR185C UPS3 SGDID:S000002593, Chr IV from 832473-831934, reverse complement, Verified ORF, "Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations"
>YDR186C YDR186C SGDID:S000002594, Chr IV from 835492-832859, reverse complement, Verified ORF, "Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"
>YDR187C YDR187C SGDID:S000002595, Chr IV from 836746-836228, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W"
>YDR188W CCT6 SGDID:S000002596, Chr IV from 836421-838061, Verified ORF, "Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif"
>YDR189W SLY1 SGDID:S000002597, Chr IV from 838392-840392, Verified ORF, "Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex"
>YDR190C RVB1 SGDID:S000002598, Chr IV from 841995-840604, reverse complement, Verified ORF, "Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; also referred to as pontin; member of the RUVB-like protein family"
>YDR191W HST4 SGDID:S000002599, Chr IV from 842337-843449, Verified ORF, "Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism"
>YDR192C NUP42 SGDID:S000002600, Chr IV from 844861-843569, reverse complement, Verified ORF, "Subunit of the nuclear pore complex (NPC) that localizes exclusively to the cytoplasmic side; involved in RNA export, most likely at a terminal step; interacts with Gle1p"
>YDR193W YDR193W SGDID:S000002601, Chr IV from 844554-844952, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YDR194C MSS116 SGDID:S000002602, Chr IV from 847946-845952, reverse complement, Verified ORF, "DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing"
>YDR194W-A YDR194W-A SGDID:S000028541, Chr IV from 848071-848223, Uncharacterized ORF, "Putative protein of unknown function; identified by fungal homology and RT-PCR"
>YDR195W REF2 SGDID:S000002603, Chr IV from 848599-850200, Verified ORF, "RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes"
>YDR196C CAB5 SGDID:S000002604, Chr IV from 850999-850274, reverse complement, Verified ORF, "Probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaE (encoding DPCK); detected in purified mitochondria in high-throughput studies"
>YDR197W CBS2 SGDID:S000002605, Chr IV from 851228-852397, Verified ORF, "Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader"
>YDR198C RKM2 SGDID:S000002606, Chr IV from 853972-852533, reverse complement, Verified ORF, "Ribosomal protein lysine methyltransferase, responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp"
>YDR199W YDR199W SGDID:S000002607, Chr IV from 854175-854540, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity"
>YDR200C VPS64 SGDID:S000002608, Chr IV from 856093-854279, reverse complement, Verified ORF, "Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance"
>YDR201W SPC19 SGDID:S000002609, Chr IV from 856317-856814, Verified ORF, "Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body"
>YDR202C RAV2 SGDID:S000002610, Chr IV from 857953-856898, reverse complement, Verified ORF, "Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme"
>YDR203W YDR203W SGDID:S000002611, Chr IV from 857682-857999, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YDR204W COQ4 SGDID:S000002612, Chr IV from 858137-859144, Verified ORF, "Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex"
>YDR205W MSC2 SGDID:S000002613, Chr IV from 859346-861520, Verified ORF, "Member of the cation diffusion facilitator family, localizes to the endoplasmic reticulum and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids"
>YDR206W EBS1 SGDID:S000002614, Chr IV from 862054-864708, Verified ORF, "Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors"
>YDR207C UME6 SGDID:S000002615, Chr IV from 867522-865012, reverse complement, Verified ORF, "Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p"
>YDR208W MSS4 SGDID:S000002616, Chr IV from 868224-870563, Verified ORF, "Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation"
>YDR209C YDR209C SGDID:S000002617, Chr IV from 871449-871036, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W."
>YDR210C-C YDR210C-C SGDID:S000007409, Chr IV from 883927-882605, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YDR210C-D YDR210C-D SGDID:S000007410, Chr IV from 882621-878659,883927-882623, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YDR210W YDR210W SGDID:S000002618, Chr IV from 871074-871301, Uncharacterized ORF, "Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery"
>YDR210W-A YDR210W-A SGDID:S000007392, Chr IV from 872112-873428, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YDR210W-B YDR210W-B SGDID:S000007393, Chr IV from 872112-873404,873406-877425, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YDR211W GCD6 SGDID:S000002619, Chr IV from 884727-886865, Verified ORF, "Catalytic epsilon subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression"
>YDR212W TCP1 SGDID:S000002620, Chr IV from 887232-888911, Verified ORF, "Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein"
>YDR213W UPC2 SGDID:S000002621, Chr IV from 889751-892492, Verified ORF, "Sterol regulatory element binding protein, induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; Ecm22p homolog; relocates from intracellular membranes to perinuclear foci on sterol depletion"
>YDR214W AHA1 SGDID:S000002622, Chr IV from 892875-893927, Verified ORF, "Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock"
>YDR215C YDR215C SGDID:S000002623, Chr IV from 894502-894089, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein"
>YDR216W ADR1 SGDID:S000002624, Chr IV from 895035-899006, Verified ORF, "Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization"
>YDR217C RAD9 SGDID:S000002625, Chr IV from 903480-899551, reverse complement, Verified ORF, "DNA damage-dependent checkpoint protein, required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; potential Cdc28p substrate"
>YDR218C SPR28 SGDID:S000002626, Chr IV from 905052-903781, reverse complement, Verified ORF, "Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation"
>YDR219C MFB1 SGDID:S000002627, Chr IV from 906852-905455, reverse complement, Verified ORF, "Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding"
>YDR220C YDR220C SGDID:S000002628, Chr IV from 907293-907000, reverse complement, Dubious ORF, "Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein"
>YDR221W GTB1 SGDID:S000002629, Chr IV from 907330-909438, Verified ORF, "Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p, involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER"
>YDR222W YDR222W SGDID:S000002630, Chr IV from 910054-911301, Uncharacterized ORF, "Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern"
>YDR223W CRF1 SGDID:S000002631, Chr IV from 912099-913502, Verified ORF, "Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain"
>YDR224C HTB1 SGDID:S000002632, Chr IV from 914712-914317, reverse complement, Verified ORF, "Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation"
>YDR225W HTA1 SGDID:S000002633, Chr IV from 915530-915928, Verified ORF, "Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p"
>YDR226W ADK1 SGDID:S000002634, Chr IV from 916486-917154, Verified ORF, "Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence"
>YDR227W SIR4 SGDID:S000002635, Chr IV from 917571-921647, Verified ORF, "Silent information regulator that, together with SIR2 and SIR3, is involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; potentially phosphorylated by Cdc28p; some alleles of SIR4 prolong lifespan"
>YDR228C PCF11 SGDID:S000002636, Chr IV from 923806-921926, reverse complement, Verified ORF, "mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p)"
>YDR229W IVY1 SGDID:S000002637, Chr IV from 924785-926146, Verified ORF, "Phospholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase"
>YDR230W YDR230W SGDID:S000002638, Chr IV from 926223-926570, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20"
>YDR231C COX20 SGDID:S000002639, Chr IV from 926910-926293, reverse complement, Verified ORF, "Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase"
>YDR232W HEM1 SGDID:S000002640, Chr IV from 927452-929098, Verified ORF, "5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p"
>YDR233C RTN1 SGDID:S000002641, Chr IV from 930357-929470, reverse complement, Verified ORF, "ER membrane protein that interacts with Sey1p to maintain ER morphology; interacts with exocyst subunit Sec6p, with Yip3p, and with Sbh1p; null mutant has an altered ER morphology; member of the RTNLA (reticulon-like A) subfamily"
>YDR234W LYS4 SGDID:S000002642, Chr IV from 931129-933210, Verified ORF, "Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway"
>YDR235W PRP42 SGDID:S000002643, Chr IV from 933504-935138, Verified ORF, "U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats"
>YDR236C FMN1 SGDID:S000002644, Chr IV from 935892-935236, reverse complement, Verified ORF, "Riboflavin kinase, phosphorylates riboflavin to form riboflavin monophosphate (FMN), which is a necessary cofactor for many enzymes; localizes to microsomes and to the mitochondrial inner membrane"
>YDR237W MRPL7 SGDID:S000002645, Chr IV from 936615-937493, Verified ORF, "Mitochondrial ribosomal protein of the large subunit"
>YDR238C SEC26 SGDID:S000002646, Chr IV from 940816-937895, reverse complement, Verified ORF, "Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)"
>YDR239C YDR239C SGDID:S000002647, Chr IV from 943420-941057, reverse complement, Verified ORF, "Protein of unknown function that may interact with ribosomes, based on co-purification experiments"
>YDR240C SNU56 SGDID:S000002648, Chr IV from 945152-943674, reverse complement, Verified ORF, "Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex"
>YDR241W BUD26 SGDID:S000002649, Chr IV from 945151-945438, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay"
>YDR242W AMD2 SGDID:S000002650, Chr IV from 946807-948456, Verified ORF, "Putative amidase"
>YDR243C PRP28 SGDID:S000002651, Chr IV from 950284-948518, reverse complement, Verified ORF, "RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site"
>YDR244W PEX5 SGDID:S000002652, Chr IV from 950563-952401, Verified ORF, "Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions"
>YDR245W MNN10 SGDID:S000002653, Chr IV from 952800-953981, Verified ORF, "Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family"
>YDR246W TRS23 SGDID:S000002654, Chr IV from 954288-954947, Verified ORF, "One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4"
>YDR246W-A YDR246W-A SGDID:S000028542, Chr IV from 955133-955333, Uncharacterized ORF, "Putative protein of unknown function; identified by fungal homology and RT-PCR"
>YDR247W VHS1 SGDID:S000002655, Chr IV from 956013-957398, Verified ORF, "Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p"
>YDR248C YDR248C SGDID:S000002656, Chr IV from 958339-957758, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1"
>YDR249C YDR249C SGDID:S000002657, Chr IV from 959802-958681, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YDR250C YDR250C SGDID:S000002658, Chr IV from 960361-960086, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data"
>YDR251W PAM1 SGDID:S000002659, Chr IV from 960614-963106, Verified ORF, "Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype"
>YDR252W BTT1 SGDID:S000002660, Chr IV from 963412-963861, Verified ORF, "Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3"
>YDR253C MET32 SGDID:S000002661, Chr IV from 964565-963990, reverse complement, Verified ORF, "Zinc-finger DNA-binding protein, involved in transcriptional regulation of the methionine biosynthetic genes, similar to Met31p"
>YDR254W CHL4 SGDID:S000002662, Chr IV from 965113-966489, Verified ORF, "Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; peripheral component of the Ctf19 kinetochore subcomplex that interacts with Ctf19p, Ctf3p, Iml3p and Mif2p"
>YDR255C RMD5 SGDID:S000002663, Chr IV from 967822-966557, reverse complement, Verified ORF, "Conserved protein that has an E3-like ubiquitin ligase activity necessary for polyubiquitination and degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase; also required for sporulation; has a degenerate RING finger domain"
>YDR256C CTA1 SGDID:S000002664, Chr IV from 969680-968133, reverse complement, Verified ORF, "Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation"
>YDR257C RKM4 SGDID:S000002665, Chr IV from 971474-969990, reverse complement, Verified ORF, "Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein"
>YDR258C HSP78 SGDID:S000002666, Chr IV from 974243-971808, reverse complement, Verified ORF, "Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates"
>YDR259C YAP6 SGDID:S000002667, Chr IV from 975782-974631, reverse complement, Verified ORF, "Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism"
>YDR260C SWM1 SGDID:S000002668, Chr IV from 977229-976717, reverse complement, Verified ORF, "Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation"
>YDR261C EXG2 SGDID:S000002669, Chr IV from 979209-977521, reverse complement, Verified ORF, "Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor"
>YDR261C-C YDR261C-C SGDID:S000007394, Chr IV from 992349-991027, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; in YDRCTY1-3 TYB is mutant and probably non-functional"
>YDR261C-D YDR261C-D SGDID:S000007395, Chr IV from 991043-987534,992349-991045, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; in YDRCTY1-3 TYB is mutant and probably non-functional"
>YDR261W-A YDR261W-A SGDID:S000007396, Chr IV from 981462-982778, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YDR261W-B YDR261W-B SGDID:S000007397, Chr IV from 981462-982754,982756-986775, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YDR262W YDR262W SGDID:S000002670, Chr IV from 993134-993952, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment"
>YDR263C DIN7 SGDID:S000002671, Chr IV from 995534-994242, reverse complement, Verified ORF, "Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination"
>YDR264C AKR1 SGDID:S000002672, Chr IV from 998323-996029, reverse complement, Verified ORF, "Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats"
>YDR265W PEX10 SGDID:S000002673, Chr IV from 998864-999877, Verified ORF, "Peroxisomal membrane E3 ubiquitin ligase, required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders"
>YDR266C YDR266C SGDID:S000002674, Chr IV from 1002023-1000104, reverse complement, Verified ORF, "Protein of unknown function that may interact with ribosomes, based on co-purification experiments;green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; contains a RING finger domain"
>YDR267C CIA1 SGDID:S000002675, Chr IV from 1003502-1002510, reverse complement, Verified ORF, "WD40 repeat protein involved in assembly of cytosolic and nuclear iron-sulfur proteins; similar to the human Ciao1 protein; YDR267C is an essential gene"
>YDR268W MSW1 SGDID:S000002676, Chr IV from 1004004-1005143, Verified ORF, "Mitochondrial tryptophanyl-tRNA synthetase"
>YDR269C YDR269C SGDID:S000002677, Chr IV from 1005988-1005665, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YDR270W CCC2 SGDID:S000002678, Chr IV from 1005675-1008689, Verified ORF, "Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases"
>YDR271C YDR271C SGDID:S000002679, Chr IV from 1008766-1008395, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W"
>YDR272W GLO2 SGDID:S000002680, Chr IV from 1009010-1009834, Verified ORF, "Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate"
>YDR273W DON1 SGDID:S000002681, Chr IV from 1010176-1011273, Verified ORF, "Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II"
>YDR274C YDR274C SGDID:S000002682, Chr IV from 1011960-1011589, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YDR275W BSC2 SGDID:S000002683, Chr IV from 1012252-1012959, Verified ORF, "Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression"
>YDR276C PMP3 SGDID:S000002684, Chr IV from 1013643-1013476, reverse complement, Verified ORF, "Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential"
>YDR277C MTH1 SGDID:S000002685, Chr IV from 1015702-1014401, reverse complement, Verified ORF, "Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation"
>YDR278C YDR278C SGDID:S000002686, Chr IV from 1017318-1017001, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YDR279W RNH202 SGDID:S000002687, Chr IV from 1019368-1020420, Verified ORF, "Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome"
>YDR280W RRP45 SGDID:S000002688, Chr IV from 1020747-1021664, Verified ORF, "Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9)"
>YDR281C PHM6 SGDID:S000002689, Chr IV from 1022321-1022007, reverse complement, Verified ORF, "Protein of unknown function, expression is regulated by phosphate levels"
>YDR282C YDR282C SGDID:S000002690, Chr IV from 1024755-1023511, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YDR283C GCN2 SGDID:S000002691, Chr IV from 1030049-1025070, reverse complement, Verified ORF, "Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control"
>YDR284C DPP1 SGDID:S000002692, Chr IV from 1031419-1030550, reverse complement, Verified ORF, "Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism"
>YDR285W ZIP1 SGDID:S000002693, Chr IV from 1032436-1035063, Verified ORF, "Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate"
>YDR286C YDR286C SGDID:S000002694, Chr IV from 1035575-1035231, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site"
>YDR287W INM2 SGDID:S000002695, Chr IV from 1035995-1036873, Verified ORF, "Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy"
>YDR288W NSE3 SGDID:S000002696, Chr IV from 1037195-1038106, Verified ORF, "Essential subunit of the Mms21-Smc5-Smc6 complex; protein of unknown function; required for DNA repair and growth"
>YDR289C RTT103 SGDID:S000002697, Chr IV from 1039509-1038280, reverse complement, Verified ORF, "Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition"
>YDR290W YDR290W SGDID:S000002698, Chr IV from 1039370-1039699, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103"
>YDR291W HRQ1 SGDID:S000002699, Chr IV from 1039728-1042961, Uncharacterized ORF, "Putative RecQ helicase; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)"
>YDR292C SRP101 SGDID:S000002700, Chr IV from 1045011-1043146, reverse complement, Verified ORF, "Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p"
>YDR293C SSD1 SGDID:S000002701, Chr IV from 1049392-1045640, reverse complement, Verified ORF, "RNA-binding protein with a role in maintenance of cellular integrity, interacts with components of the TOR pathway; ssd1 mutant of a clinical S. cerevisiae strain displays elevated virulence"
>YDR294C DPL1 SGDID:S000002702, Chr IV from 1052228-1050459, reverse complement, Verified ORF, "Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate"
>YDR295C HDA2 SGDID:S000002703, Chr IV from 1054647-1052623, reverse complement, Verified ORF, "Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance"
>YDR296W MHR1 SGDID:S000002704, Chr IV from 1055212-1055892, Verified ORF, "Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress"
>YDR297W SUR2 SGDID:S000002705, Chr IV from 1056551-1057600, Verified ORF, "Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis"
>YDR298C ATP5 SGDID:S000002706, Chr IV from 1058814-1058176, reverse complement, Verified ORF, "Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated"
>YDR299W BFR2 SGDID:S000002707, Chr IV from 1059627-1061231, Verified ORF, "Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock"
>YDR300C PRO1 SGDID:S000002708, Chr IV from 1062791-1061505, reverse complement, Verified ORF, "Gamma-glutamyl kinase, catalyzes the first step in proline biosynthesis"
>YDR301W CFT1 SGDID:S000002709, Chr IV from 1063352-1067425, Verified ORF, "RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF"
>YDR302W GPI11 SGDID:S000002710, Chr IV from 1067731-1068390, Verified ORF, "ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog"
>YDR303C RSC3 SGDID:S000002711, Chr IV from 1071386-1068729, reverse complement, Verified ORF, "Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p"
>YDR304C CPR5 SGDID:S000002712, Chr IV from 1072557-1071880, reverse complement, Verified ORF, "Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER"
>YDR305C HNT2 SGDID:S000002713, Chr IV from 1073312-1072746,1073488-1073402, reverse complement, Verified ORF, "Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins"
>YDR306C YDR306C SGDID:S000002714, Chr IV from 1075171-1073735, reverse complement, Uncharacterized ORF, "F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain"
>YDR307W YDR307W SGDID:S000002715, Chr IV from 1075865-1077853, Uncharacterized ORF, "Putative protein of unknown function"
>YDR308C SRB7 SGDID:S000002716, Chr IV from 1078449-1078027, reverse complement, Verified ORF, "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p"
>YDR309C GIC2 SGDID:S000002717, Chr IV from 1080199-1079048, reverse complement, Verified ORF, "Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region"
>YDR310C SUM1 SGDID:S000002718, Chr IV from 1084316-1081128, reverse complement, Verified ORF, "Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint"
>YDR311W TFB1 SGDID:S000002719, Chr IV from 1085065-1086993, Verified ORF, "Subunit of TFIIH and nucleotide excision repair factor 3 complexes, required for nucleotide excision repair, target for transcriptional activators"
>YDR312W SSF2 SGDID:S000002720, Chr IV from 1087581-1088942, Verified ORF, "Protein required for ribosomal large subunit maturation, functionally redundant with Ssf1p; member of the Brix family"
>YDR313C PIB1 SGDID:S000002721, Chr IV from 1090079-1089219, reverse complement, Verified ORF, "RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain"
>YDR314C RAD34 SGDID:S000002722, Chr IV from 1092511-1090433, reverse complement, Verified ORF, "Protein involved in nucleotide excision repair (NER); homologous to RAD4"
>YDR315C IPK1 SGDID:S000002723, Chr IV from 1093586-1092741, reverse complement, Verified ORF, "Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable"
>YDR316W OMS1 SGDID:S000002724, Chr IV from 1093763-1095178, Verified ORF, "Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations"
>YDR316W-A YDR316W-A SGDID:S000007398, Chr IV from 1096064-1097386, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YDR316W-B YDR316W-B SGDID:S000007399, Chr IV from 1096064-1097368,1097370-1101332, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YDR317W HIM1 SGDID:S000002725, Chr IV from 1102184-1103428, Verified ORF, "Protein of unknown function involved in DNA repair"
>YDR318W MCM21 SGDID:S000002726, Chr IV from 1103758-1103809,1103893-1104947, Verified ORF, "Protein involved in minichromosome maintenance; component of the COMA complex (Ctf19p, Okp1p, Mcm21p, Ame1p) that bridges kinetochore subunits that are in contact with centromeric DNA and the subunits bound to microtubules"
>YDR319C YDR319C SGDID:S000002727, Chr IV from 1105827-1105003, reverse complement, Uncharacterized ORF, "Putative protein of unknown function, identified as an ortholog of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens"
>YDR320C SWA2 SGDID:S000002728, Chr IV from 1108101-1106095, reverse complement, Verified ORF, "Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles"
>YDR320C-A DAD4 SGDID:S000007604, Chr IV from 1108498-1108280, reverse complement, Verified ORF, "Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis"
>YDR320W-B YDR320W-B SGDID:S000028821, Chr IV from 1108484-1108621, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene DAD4/YDR320C-A"
>YDR321W ASP1 SGDID:S000002729, Chr IV from 1108702-1109847, Verified ORF, "Cytosolic L-asparaginase, involved in asparagine catabolism"
>YDR322C-A TIM11 SGDID:S000007255, Chr IV from 1112293-1112003, reverse complement, Verified ORF, "Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase"
>YDR322W MRPL35 SGDID:S000002730, Chr IV from 1110589-1111692, Verified ORF, "Mitochondrial ribosomal protein of the large subunit"
>YDR323C PEP7 SGDID:S000002731, Chr IV from 1114027-1112480, reverse complement, Verified ORF, "Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance"
>YDR324C UTP4 SGDID:S000002732, Chr IV from 1116763-1114433, reverse complement, Verified ORF, "Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript"
>YDR325W YCG1 SGDID:S000002733, Chr IV from 1117126-1120233, Verified ORF, "Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding of the condensin complex; required for clustering of tRNA genes at the nucleolus"
>YDR326C YSP2 SGDID:S000002734, Chr IV from 1124925-1120609, reverse complement, Verified ORF, "Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification"
>YDR327W YDR327W SGDID:S000002735, Chr IV from 1125302-1125628, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SKP1"
>YDR328C SKP1 SGDID:S000002736, Chr IV from 1126018-1125434, reverse complement, Verified ORF, "Evolutionarily conserved kinetochore protein that is part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase"
>YDR329C PEX3 SGDID:S000002737, Chr IV from 1127595-1126270, reverse complement, Verified ORF, "Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p"
>YDR330W UBX5 SGDID:S000002738, Chr IV from 1127872-1129374, Verified ORF, "UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p"
>YDR331W GPI8 SGDID:S000002739, Chr IV from 1129588-1130823, Verified ORF, "ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog"
>YDR332W IRC3 SGDID:S000002740, Chr IV from 1131001-1133070, Verified ORF, "Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion"
>YDR333C YDR333C SGDID:S000002741, Chr IV from 1135431-1133260, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YDR334W SWR1 SGDID:S000002742, Chr IV from 1135932-1140476, Verified ORF, "Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A"
>YDR335W MSN5 SGDID:S000002743, Chr IV from 1141168-1144842, Verified ORF, "Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm"
>YDR336W YDR336W SGDID:S000002744, Chr IV from 1145092-1146036, Uncharacterized ORF, "Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene"
>YDR337W MRPS28 SGDID:S000002745, Chr IV from 1146319-1147179, Verified ORF, "Mitochondrial ribosomal protein of the small subunit"
>YDR338C YDR338C SGDID:S000002746, Chr IV from 1149466-1147379, reverse complement, Uncharacterized ORF, "Putative protein of unknown function, member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily"
>YDR339C FCF1 SGDID:S000002747, Chr IV from 1150520-1149951, reverse complement, Verified ORF, "Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p"
>YDR340W YDR340W SGDID:S000002748, Chr IV from 1150881-1151183, Dubious ORF, "Putative protein of unknown function"
>YDR341C YDR341C SGDID:S000002749, Chr IV from 1153626-1151803, reverse complement, Verified ORF, "Arginyl-tRNA synthetase, proposed to be cytoplasmic but the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YDR342C HXT7 SGDID:S000002750, Chr IV from 1155928-1154216, reverse complement, Verified ORF, "High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels"
>YDR343C HXT6 SGDID:S000002751, Chr IV from 1161320-1159608, reverse complement, Verified ORF, "High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3"
>YDR344C YDR344C SGDID:S000002752, Chr IV from 1162449-1162006, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YDR345C HXT3 SGDID:S000002753, Chr IV from 1164660-1162957, reverse complement, Verified ORF, "Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions"
>YDR346C SVF1 SGDID:S000002754, Chr IV from 1168659-1167214, reverse complement, Verified ORF, "Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance"
>YDR347W MRP1 SGDID:S000002755, Chr IV from 1169178-1170143, Verified ORF, "Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein"
>YDR348C YDR348C SGDID:S000002756, Chr IV from 1171825-1170326, reverse complement, Uncharacterized ORF, "Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud neck; potential Cdc28p substrate"
>YDR349C YPS7 SGDID:S000002757, Chr IV from 1174176-1172386, reverse complement, Verified ORF, "Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; located in the cytoplasm and endoplasmic reticulum"
>YDR350C ATP22 SGDID:S000002758, Chr IV from 1178174-1176120, reverse complement, Verified ORF, "Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane"
>YDR351W SBE2 SGDID:S000002759, Chr IV from 1178666-1181260, Verified ORF, "Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth"
>YDR352W YDR352W SGDID:S000002760, Chr IV from 1181801-1182754, Uncharacterized ORF, "Putative protein of unknown function"
>YDR353W TRR1 SGDID:S000002761, Chr IV from 1183299-1184258, Verified ORF, "Cytoplasmic thioredoxin reductase, key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress"
>YDR354C-A YDR354C-A SGDID:S000028613, Chr IV from 1185282-1185139, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; completely overlaps TRP4; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YDR354W TRP4 SGDID:S000002762, Chr IV from 1184747-1185889, Verified ORF, "Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis"
>YDR355C YDR355C SGDID:S000002763, Chr IV from 1186369-1186067, reverse complement, Dubious ORF, "Dubious: Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified essential ORF SPC110/YDR356W"
>YDR356W SPC110 SGDID:S000002764, Chr IV from 1186107-1188941, Verified ORF, "Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner"
>YDR357C CNL1 SGDID:S000002765, Chr IV from 1189567-1189199, reverse complement, Uncharacterized ORF, "Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"
>YDR358W GGA1 SGDID:S000002766, Chr IV from 1190059-1191732, Verified ORF, "Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi"
>YDR359C EAF1 SGDID:S000002767, Chr IV from 1194884-1191936, reverse complement, Verified ORF, "Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1"
>YDR360W OPI7 SGDID:S000002768, Chr IV from 1194598-1195032, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C."
>YDR361C BCP1 SGDID:S000002769, Chr IV from 1196263-1195412, reverse complement, Verified ORF, "Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport"
>YDR362C TFC6 SGDID:S000002770, Chr IV from 1198697-1196679, reverse complement, Verified ORF, "One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110"
>YDR363W ESC2 SGDID:S000002771, Chr IV from 1199183-1200553, Verified ORF, "Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member"
>YDR363W-A SEM1 SGDID:S000007235, Chr IV from 1202128-1202397, Verified ORF, "Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; involved in mRNA export mediated by the TREX-2 complex (Sac3p-Thp1p); ortholog of human DSS1"
>YDR364C CDC40 SGDID:S000002772, Chr IV from 1204210-1202843, reverse complement, Verified ORF, "Pre-mRNA splicing factor, important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression; required for DNA synthesis during mitosis and meiosis; has WD repeats"
>YDR365C ESF1 SGDID:S000002773, Chr IV from 1206383-1204497, reverse complement, Verified ORF, "Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels"
>YDR365W-A YDR365W-A SGDID:S000007400, Chr IV from 1206997-1208319, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YDR365W-B YDR365W-B SGDID:S000007401, Chr IV from 1206997-1208301,1208303-1212265, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YDR366C YDR366C SGDID:S000002774, Chr IV from 1212836-1212438, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YDR367W KEI1 SGDID:S000002775, Chr IV from 1212848-1212877,1212979-1213614, Verified ORF, "Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene"
>YDR368W YPR1 SGDID:S000002776, Chr IV from 1213904-1214842, Verified ORF, "NADPH-dependent aldo-keto reductase, reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases"
>YDR369C XRS2 SGDID:S000002777, Chr IV from 1217580-1215016, reverse complement, Verified ORF, "Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling"
>YDR370C YDR370C SGDID:S000002778, Chr IV from 1219110-1217782, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YDR371C-A YDR371C-A SGDID:S000028822, Chr IV from 1219613-1219509, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completeley overlaps the uncharacterized gene CTS2/YDR371W; identified by expression profiling and mass spectrometry"
>YDR371W CTS2 SGDID:S000002779, Chr IV from 1219413-1220948, Uncharacterized ORF, "Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect"
>YDR372C VPS74 SGDID:S000002780, Chr IV from 1222149-1221112, reverse complement, Verified ORF, "Protein required for Golgi localization of glycosyltransferases; binds the cytosolic domains of Golgi glycosyltransferases; binding to PtdIns4P required for Golgi targeting and function; tetramer formation required for function"
>YDR373W FRQ1 SGDID:S000002781, Chr IV from 1222759-1223331, Verified ORF, "N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily"
>YDR374C YDR374C SGDID:S000002782, Chr IV from 1224394-1223474, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YDR374W-A YDR374W-A SGDID:S000113553, Chr IV from 1224757-1225026, Uncharacterized ORF, "Putative protein of unknown function"
>YDR375C BCS1 SGDID:S000002783, Chr IV from 1226536-1225166, reverse complement, Verified ORF, "Mitochondrial protein of the AAA ATPase family; has ATP-dependent chaperone activity; required for assembly of Rip1p and Qcr10p into cytochrome bc(1) complex; mutations in human homolog BCS1L are linked to neonatal mitochondrial diseases"
>YDR376W ARH1 SGDID:S000002784, Chr IV from 1226822-1228303, Verified ORF, "Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability"
>YDR377W ATP17 SGDID:S000002785, Chr IV from 1228611-1228916, Verified ORF, "Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis"
>YDR378C LSM6 SGDID:S000002786, Chr IV from 1229609-1229349, reverse complement, Verified ORF, "Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA"
>YDR379C-A YDR379C-A SGDID:S000007605, Chr IV from 1233517-1233278, reverse complement, Verified ORF, "Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy"
>YDR379W RGA2 SGDID:S000002787, Chr IV from 1230167-1233196, Verified ORF, "GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p"
>YDR380W ARO10 SGDID:S000002788, Chr IV from 1234218-1236125, Verified ORF, "Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway"
>YDR381C-A YDR381C-A SGDID:S000007650, Chr IV from 1238630-1238312,1238850-1238825, reverse complement, Verified ORF, "Protein of unknown function, localized to the mitochondrial outer membrane"
>YDR381W YRA1 SGDID:S000002789, Chr IV from 1236558-1236842,1237609-1238004, Verified ORF, "RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member"
>YDR382W RPP2B SGDID:S000002790, Chr IV from 1239492-1239824, Verified ORF, "Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm"
>YDR383C NKP1 SGDID:S000002791, Chr IV from 1240676-1239960, reverse complement, Verified ORF, "Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p)"
>YDR384C ATO3 SGDID:S000002792, Chr IV from 1242031-1241204, reverse complement, Verified ORF, "Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters"
>YDR385W EFT2 SGDID:S000002793, Chr IV from 1243230-1245758, Verified ORF, "Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin"
>YDR386W MUS81 SGDID:S000002794, Chr IV from 1246084-1247982, Verified ORF, "Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein"
>YDR387C YDR387C SGDID:S000002795, Chr IV from 1249821-1248154, reverse complement, Uncharacterized ORF, "Putative transporter, member of the sugar porter family; YDR387C is not an essential gene"
>YDR388W RVS167 SGDID:S000002796, Chr IV from 1250186-1251634, Verified ORF, "Actin-associated protein, interacts with Rvs161p to regulate actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; homolog of mammalian amphiphysin"
>YDR389W SAC7 SGDID:S000002797, Chr IV from 1252537-1254501, Verified ORF, "GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate"
>YDR390C UBA2 SGDID:S000002798, Chr IV from 1256847-1254937, reverse complement, Verified ORF, "Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability"
>YDR391C YDR391C SGDID:S000002799, Chr IV from 1258056-1257358, reverse complement, Uncharacterized ORF, "Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus"
>YDR392W SPT3 SGDID:S000002800, Chr IV from 1258696-1259709, Verified ORF, "Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters"
>YDR393W SHE9 SGDID:S000002801, Chr IV from 1259901-1261271, Verified ORF, "Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex"
>YDR394W RPT3 SGDID:S000002802, Chr IV from 1261681-1262967, Verified ORF, "One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B"
>YDR395W SXM1 SGDID:S000002803, Chr IV from 1263324-1266158, Verified ORF, "Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1"
>YDR396W YDR396W SGDID:S000002804, Chr IV from 1266295-1266795, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein; extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex"
>YDR397C NCB2 SGDID:S000002805, Chr IV from 1266769-1266366,1266898-1266862, reverse complement, Verified ORF, "Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta"
>YDR398W UTP5 SGDID:S000002806, Chr IV from 1267471-1269402, Verified ORF, "Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit"
>YDR399W HPT1 SGDID:S000002807, Chr IV from 1270068-1270733, Verified ORF, "Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome"
>YDR400W URH1 SGDID:S000002808, Chr IV from 1271063-1272085, Verified ORF, "Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways"
>YDR401W YDR401W SGDID:S000002809, Chr IV from 1272223-1272786, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YDR402C DIT2 SGDID:S000002810, Chr IV from 1273703-1272234, reverse complement, Verified ORF, "N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s"
>YDR403W DIT1 SGDID:S000002811, Chr IV from 1274602-1276212, Verified ORF, "Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure"
>YDR404C RPB7 SGDID:S000002812, Chr IV from 1277169-1276654, reverse complement, Verified ORF, "RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions"
>YDR405W MRP20 SGDID:S000002813, Chr IV from 1277646-1278437, Verified ORF, "Mitochondrial ribosomal protein of the large subunit"
>YDR406W PDR15 SGDID:S000002814, Chr IV from 1279210-1283799, Verified ORF, "Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element"
>YDR406W-A YDR406W-A SGDID:S000028543, Chr IV from 1283799-1284044, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR"
>YDR407C TRS120 SGDID:S000002815, Chr IV from 1287938-1284069, reverse complement, Verified ORF, "One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic"
>YDR408C ADE8 SGDID:S000002816, Chr IV from 1288859-1288215, reverse complement, Verified ORF, "Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway"
>YDR409W SIZ1 SGDID:S000002817, Chr IV from 1289406-1292120, Verified ORF, "SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring"
>YDR410C STE14 SGDID:S000002818, Chr IV from 1293091-1292372, reverse complement, Verified ORF, "Farnesyl cysteine-carboxyl methyltransferase, mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane"
>YDR411C DFM1 SGDID:S000002819, Chr IV from 1294394-1293369, reverse complement, Verified ORF, "ER localized derlin-like family member involved in ER stress and homeostasis; not involved in ERAD or substrate retrotranslocation; interacts with CDC48; contains four transmembrane domains and two SHP boxes"
>YDR412W RRP17 SGDID:S000002820, Chr IV from 1294693-1295400, Verified ORF, "Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions; exonuclease required for 5&#8242; end processing of pre-60S ribosomal RNA"
>YDR413C YDR413C SGDID:S000002821, Chr IV from 1295411-1294836, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the essential uncharacterized ORF YDR412W that is implicated in rRNA processing"
>YDR414C ERD1 SGDID:S000002822, Chr IV from 1296686-1295598, reverse complement, Verified ORF, "Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)"
>YDR415C YDR415C SGDID:S000002823, Chr IV from 1298161-1297037, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YDR416W SYF1 SGDID:S000002824, Chr IV from 1298432-1301011, Verified ORF, "Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans"
>YDR417C YDR417C SGDID:S000002825, Chr IV from 1301926-1301555, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W"
>YDR418W RPL12B SGDID:S000002826, Chr IV from 1301616-1302113, Verified ORF, "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins"
>YDR419W RAD30 SGDID:S000002827, Chr IV from 1303174-1305072, Verified ORF, "DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; mutations in human pol eta are responsible for XPV"
>YDR420W HKR1 SGDID:S000002828, Chr IV from 1306267-1311675, Verified ORF, "Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection"
>YDR421W ARO80 SGDID:S000002829, Chr IV from 1312040-1314892, Verified ORF, "Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids"
>YDR422C SIP1 SGDID:S000002830, Chr IV from 1317773-1315326, reverse complement, Verified ORF, "Alternate beta-subunit of the Snf1p kinase complex, may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions"
>YDR423C CAD1 SGDID:S000002831, Chr IV from 1319275-1318046, reverse complement, Verified ORF, "AP-1-like basic leucine zipper (bZIP) transcriptional activator involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA"
>YDR424C DYN2 SGDID:S000002832, Chr IV from 1319617-1319387,1319720-1319698,1319841-1319817, reverse complement, Verified ORF, "Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex"
>YDR425W SNX41 SGDID:S000002833, Chr IV from 1320064-1321941, Verified ORF, "Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; interacts with Snx4p"
>YDR426C YDR426C SGDID:S000002834, Chr IV from 1322006-1321629, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SNX41"
>YDR427W RPN9 SGDID:S000002835, Chr IV from 1322205-1323386, Verified ORF, "Non-ATPase regulatory subunit of the 26S proteasome, has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects"
>YDR428C BNA7 SGDID:S000002836, Chr IV from 1324239-1323454, reverse complement, Verified ORF, "Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine"
>YDR429C TIF35 SGDID:S000002837, Chr IV from 1325301-1324477, reverse complement, Verified ORF, "eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation"
>YDR430C CYM1 SGDID:S000002838, Chr IV from 1328470-1325501, reverse complement, Verified ORF, "Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology"
>YDR431W YDR431W SGDID:S000002839, Chr IV from 1328390-1328701, Dubious ORF, "Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YDR432W NPL3 SGDID:S000002840, Chr IV from 1328783-1330027, Verified ORF, "RNA-binding protein that promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm"
>YDR433W YDR433W SGDID:S000002841, Chr IV from 1329600-1330040, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YDR434W GPI17 SGDID:S000002842, Chr IV from 1331237-1332841, Verified ORF, "Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Sp homolog"
>YDR435C PPM1 SGDID:S000002843, Chr IV from 1333969-1332983, reverse complement, Verified ORF, "Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits"
>YDR436W PPZ2 SGDID:S000002844, Chr IV from 1334821-1336953, Verified ORF, "Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance"
>YDR437W GPI19 SGDID:S000002845, Chr IV from 1337352-1337774, Verified ORF, "Subunit of GPI-GlcNAc transferase involved in synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), which is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis, shares similarity with mammalian PIG-P"
>YDR438W THI74 SGDID:S000002846, Chr IV from 1338274-1339386, Verified ORF, "Mitochondrial transporter repressible by thiamine"
>YDR439W LRS4 SGDID:S000002847, Chr IV from 1339676-1340719, Verified ORF, "Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation"
>YDR440W DOT1 SGDID:S000002848, Chr IV from 1342493-1344241, Verified ORF, "Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response"
>YDR441C APT2 SGDID:S000002849, Chr IV from 1345062-1344517, reverse complement, Verified ORF, "Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity"
>YDR442W YDR442W SGDID:S000002850, Chr IV from 1345647-1346039, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YDR443C SSN2 SGDID:S000002851, Chr IV from 1349938-1345676, reverse complement, Verified ORF, "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation"
>YDR444W YDR444W SGDID:S000002852, Chr IV from 1350290-1352353, Uncharacterized ORF, "Putative protein of unknown function"
>YDR445C YDR445C SGDID:S000002853, Chr IV from 1352589-1352182, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YDR446W ECM11 SGDID:S000002854, Chr IV from 1353725-1354633, Verified ORF, "Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure"
>YDR447C RPS17B SGDID:S000002855, Chr IV from 1355236-1354829,1355553-1355551, reverse complement, Verified ORF, "Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Ap and has similarity to rat S17 ribosomal protein"
>YDR448W ADA2 SGDID:S000002856, Chr IV from 1356065-1357369, Verified ORF, "Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes"
>YDR449C UTP6 SGDID:S000002857, Chr IV from 1358902-1357580, reverse complement, Verified ORF, "Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA"
>YDR450W RPS18A SGDID:S000002858, Chr IV from 1359923-1359969,1360405-1360798, Verified ORF, "Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins"
>YDR451C YHP1 SGDID:S000002859, Chr IV from 1362181-1361120, reverse complement, Verified ORF, "One of two homeobox transcriptional repressors (see also Yox1p), that bind to Mcm1p and to early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval"
>YDR452W PPN1 SGDID:S000002860, Chr IV from 1362878-1364902, Verified ORF, "Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer"
>YDR453C TSA2 SGDID:S000002861, Chr IV from 1365662-1365072, reverse complement, Verified ORF, "Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants"
>YDR454C GUK1 SGDID:S000002862, Chr IV from 1366827-1366264, reverse complement, Verified ORF, "Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins"
>YDR455C YDR455C SGDID:S000002863, Chr IV from 1367681-1367373, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W"
>YDR456W NHX1 SGDID:S000002864, Chr IV from 1367485-1369386, Verified ORF, "Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion"
>YDR457W TOM1 SGDID:S000002865, Chr IV from 1369790-1379596, Verified ORF, "E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones"
>YDR458C HEH2 SGDID:S000002866, Chr IV from 1382046-1380055, reverse complement, Verified ORF, "Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle"
>YDR459C PFA5 SGDID:S000002867, Chr IV from 1383443-1382319, reverse complement, Verified ORF, "Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain"
>YDR460W TFB3 SGDID:S000002868, Chr IV from 1383811-1384776, Verified ORF, "Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit"
>YDR461C-A YDR461C-A SGDID:S000087209, Chr IV from 1385766-1385524, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YDR461W MFA1 SGDID:S000002869, Chr IV from 1385176-1385286, Verified ORF, "Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2"
>YDR462W MRPL28 SGDID:S000002870, Chr IV from 1386073-1386516, Verified ORF, "Mitochondrial ribosomal protein of the large subunit"
>YDR463W STP1 SGDID:S000002871, Chr IV from 1386816-1388375, Verified ORF, "Transcription factor, undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing"
>YDR464C-A YDR464C-A SGDID:S000028614, Chr IV from 1392680-1392492, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YDR464W SPP41 SGDID:S000002872, Chr IV from 1388872-1393179, Verified ORF, "Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3"
>YDR465C RMT2 SGDID:S000002873, Chr IV from 1394574-1393336, reverse complement, Verified ORF, "Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67"
>YDR466W PKH3 SGDID:S000002874, Chr IV from 1395121-1397817, Verified ORF, "Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant"
>YDR467C YDR467C SGDID:S000002875, Chr IV from 1397909-1397583, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YDR468C TLG1 SGDID:S000002876, Chr IV from 1398700-1398026, reverse complement, Verified ORF, "Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p"
>YDR469W SDC1 SGDID:S000002877, Chr IV from 1399015-1399542, Verified ORF, "Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30"
>YDR470C UGO1 SGDID:S000002878, Chr IV from 1401214-1399706, reverse complement, Verified ORF, "Protein of unknown function; outer membrane component of the mitochondrial fusion machinery; Ugo1p bind directly to Fzo1p and Mgm1p and thereby link these two GTPases during mitochondrial fusion"
>YDR471W RPL27B SGDID:S000002879, Chr IV from 1401770-1401800,1402185-1402564, Verified ORF, "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Ap and has similarity to rat L27 ribosomal protein"
>YDR472W TRS31 SGDID:S000002880, Chr IV from 1403322-1404173, Verified ORF, "One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic"
>YDR473C PRP3 SGDID:S000002881, Chr IV from 1405854-1404445, reverse complement, Verified ORF, "Splicing factor, component of the U4/U6-U5 snRNP complex"
>YDR475C JIP4 SGDID:S000002883, Chr IV from 1410094-1407464, reverse complement, Verified ORF, "Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence"
>YDR476C YDR476C SGDID:S000002884, Chr IV from 1411127-1410453, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene"
>YDR477W SNF1 SGDID:S000002885, Chr IV from 1412373-1414274, Verified ORF, "AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis"
>YDR478W SNM1 SGDID:S000002886, Chr IV from 1414575-1415171, Verified ORF, "Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP"
>YDR479C PEX29 SGDID:S000002887, Chr IV from 1416874-1415210, reverse complement, Verified ORF, "Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p"
>YDR480W DIG2 SGDID:S000002888, Chr IV from 1417399-1418370, Verified ORF, "MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p"
>YDR481C PHO8 SGDID:S000002889, Chr IV from 1420250-1418550, reverse complement, Verified ORF, "Repressible alkaline phosphatase, a glycoprotein localized to the vacuole; regulated by levels of inorganic phosphate and by a system consisting of Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides"
>YDR482C CWC21 SGDID:S000002890, Chr IV from 1420838-1420431, reverse complement, Verified ORF, "Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p"
>YDR483W KRE2 SGDID:S000002891, Chr IV from 1421157-1422485, Verified ORF, "Alpha1,2-mannosyltransferase of the Golgi involved in protein mannosylation"
>YDR484W VPS52 SGDID:S000002892, Chr IV from 1422763-1424688, Verified ORF, "Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin"
>YDR485C VPS72 SGDID:S000002893, Chr IV from 1427207-1424820, reverse complement, Verified ORF, "Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting"
>YDR486C VPS60 SGDID:S000002894, Chr IV from 1428120-1427431, reverse complement, Verified ORF, "Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p"
>YDR487C RIB3 SGDID:S000002895, Chr IV from 1428980-1428354, reverse complement, Verified ORF, "3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration"
>YDR488C PAC11 SGDID:S000002896, Chr IV from 1430789-1429188, reverse complement, Verified ORF, "Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8"
>YDR489W SLD5 SGDID:S000002897, Chr IV from 1431012-1431896, Verified ORF, "Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery"
>YDR490C PKH1 SGDID:S000002898, Chr IV from 1434268-1431968, reverse complement, Verified ORF, "Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p"
>YDR491C YDR491C SGDID:S000002899, Chr IV from 1434991-1434500, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YDR492W IZH1 SGDID:S000002900, Chr IV from 1434924-1435874, Verified ORF, "Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc"
>YDR493W MZM1 SGDID:S000002901, Chr IV from 1436217-1436588, Verified ORF, "Mitochondrial matrix protein with a role in maintaining the labile mitochondrial zinc pool; null mutant has a respiratory growth defect and an elevated frequency of mitochondrial genome loss; overexpression causes cell cycle delay or arrest"
>YDR494W RSM28 SGDID:S000002902, Chr IV from 1436930-1438015, Verified ORF, "Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation"
>YDR495C VPS3 SGDID:S000002903, Chr IV from 1441150-1438115, reverse complement, Verified ORF, "Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase"
>YDR496C PUF6 SGDID:S000002904, Chr IV from 1443403-1441433, reverse complement, Verified ORF, "Pumilio-homology domain protein that binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; also co-sediments with the 60S ribosomal subunit and is required for its biogenesis"
>YDR497C ITR1 SGDID:S000002905, Chr IV from 1445467-1443713, reverse complement, Verified ORF, "Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p"
>YDR498C SEC20 SGDID:S000002906, Chr IV from 1446994-1445843, reverse complement, Verified ORF, "Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; interacts with the Dsl1p complex through Tip20p"
>YDR499W LCD1 SGDID:S000002907, Chr IV from 1447830-1450073, Verified ORF, "Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP"
>YDR500C RPL37B SGDID:S000002908, Chr IV from 1450457-1450198,1450853-1450847, reverse complement, Verified ORF, "Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Ap and to rat L37 ribosomal protein"
>YDR501W PLM2 SGDID:S000002909, Chr IV from 1451353-1452918, Verified ORF, "Forkhead Associated domain containing protein and putative transcription factor found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; similar to TOS4"
>YDR502C SAM2 SGDID:S000002910, Chr IV from 1454464-1453310, reverse complement, Verified ORF, "S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)"
>YDR503C LPP1 SGDID:S000002911, Chr IV from 1455866-1455042, reverse complement, Verified ORF, "Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA"
>YDR504C SPG3 SGDID:S000002912, Chr IV from 1456694-1456311, reverse complement, Verified ORF, "Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources"
>YDR505C PSP1 SGDID:S000002913, Chr IV from 1459220-1456695, reverse complement, Verified ORF, "Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition"
>YDR506C YDR506C SGDID:S000002914, Chr IV from 1461554-1459728, reverse complement, Uncharacterized ORF, "Possible membrane-localized protein"
>YDR507C GIN4 SGDID:S000002915, Chr IV from 1465786-1462358, reverse complement, Verified ORF, "Protein kinase involved in bud growth and assembly of the septin ring, proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Kcc4p and Hsl1p"
>YDR508C GNP1 SGDID:S000002916, Chr IV from 1468444-1466453, reverse complement, Verified ORF, "High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids"
>YDR509W YDR509W SGDID:S000002917, Chr IV from 1468226-1468573, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YDR510C-A YDR510C-A SGDID:S000028615, Chr IV from 1469811-1469695, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YDR510W SMT3 SGDID:S000002918, Chr IV from 1469400-1469705, Verified ORF, "Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2"
>YDR511W ACN9 SGDID:S000002919, Chr IV from 1470017-1470418, Verified ORF, "Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes"
>YDR512C EMI1 SGDID:S000002920, Chr IV from 1471063-1470500, reverse complement, Verified ORF, "Non-essential protein required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs"
>YDR513W GRX2 SGDID:S000002921, Chr IV from 1471017-1471448, Verified ORF, "Cytoplasmic glutaredoxin, thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress"
>YDR514C YDR514C SGDID:S000002922, Chr IV from 1472999-1471548, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YDR515W SLF1 SGDID:S000002923, Chr IV from 1473429-1474772, Verified ORF, "RNA binding protein that associates with polysomes; proposed to be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts"
>YDR516C EMI2 SGDID:S000002924, Chr IV from 1476476-1474974, reverse complement, Verified ORF, "Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression is regulated by glucose-repression transcription factors Mig1/2p"
>YDR517W GRH1 SGDID:S000002925, Chr IV from 1477239-1478357, Verified ORF, "Acetylated, cis-golgi localized protein involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes"
>YDR518W EUG1 SGDID:S000002926, Chr IV from 1478608-1480161, Verified ORF, "Protein disulfide isomerase of the endoplasmic reticulum lumen, function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER"
>YDR519W FPR2 SGDID:S000002927, Chr IV from 1480425-1480832, Verified ORF, "Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking"
>YDR520C URC2 SGDID:S000002928, Chr IV from 1483403-1481085, reverse complement, Uncharacterized ORF, "Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism"
>YDR521W YDR521W SGDID:S000002929, Chr IV from 1483141-1483476, Dubious ORF, "Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol"
>YDR522C SPS2 SGDID:S000002930, Chr IV from 1485303-1483795, reverse complement, Verified ORF, "Protein expressed during sporulation, redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component"
>YDR523C SPS1 SGDID:S000002931, Chr IV from 1487038-1485566, reverse complement, Verified ORF, "Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis"
>YDR524C AGE1 SGDID:S000002932, Chr IV from 1488990-1487542, reverse complement, Verified ORF, "ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif"
>YDR524C-A YDR524C-A SGDID:S000028616, Chr IV from 1489990-1489871, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YDR524C-B YDR524C-B SGDID:S000028739, Chr IV from 1489798-1489598, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YDR524W-C YDR524W-C SGDID:S000028740, Chr IV from 1489403-1489492, Uncharacterized ORF, "Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin"
>YDR525W API2 SGDID:S000002933, Chr IV from 1489905-1490234, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology"
>YDR525W-A SNA2 SGDID:S000007236, Chr IV from 1490596-1490835, Verified ORF, "Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern"
>YDR526C YDR526C SGDID:S000002934, Chr IV from 1491545-1491075, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YDR527W RBA50 SGDID:S000002935, Chr IV from 1491094-1492413, Verified ORF, "Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1"
>YDR528W HLR1 SGDID:S000002936, Chr IV from 1494586-1495857, Verified ORF, "Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A"
>YDR529C QCR7 SGDID:S000002937, Chr IV from 1496548-1496165, reverse complement, Verified ORF, "Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly"
>YDR530C APA2 SGDID:S000002938, Chr IV from 1497768-1496791, reverse complement, Verified ORF, "Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa1p"
>YDR531W CAB1 SGDID:S000002939, Chr IV from 1498232-1499335, Verified ORF, "Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA)"
>YDR532C KRE28 SGDID:S000002940, Chr IV from 1500553-1499396, reverse complement, Verified ORF, "Subunit of a kinetochore-microtubule binding complex with Spc105p that bridges centromeric heterochromatin and kinetochore MAPs and motors, and is also required for sister chromatid bi-orientation and kinetochore binding of SAC components"
>YDR533C HSP31 SGDID:S000002941, Chr IV from 1502160-1501447, reverse complement, Verified ORF, "Possible chaperone and cysteine protease with similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site"
>YDR534C FIT1 SGDID:S000002942, Chr IV from 1504900-1503314, reverse complement, Verified ORF, "Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall"
>YDR535C YDR535C SGDID:S000002943, Chr IV from 1507058-1506606,1507362-1507315, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene."
>YDR536W STL1 SGDID:S000002944, Chr IV from 1508005-1509714, Verified ORF, "Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock"
>YDR537C YDR537C SGDID:S000002945, Chr IV from 1511461-1510856, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W"
>YDR538W PAD1 SGDID:S000002946, Chr IV from 1510902-1511630, Verified ORF, "Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX"
>YDR539W FDC1 SGDID:S000002947, Chr IV from 1512094-1513605, Verified ORF, "Ferulic acid decarboxylase, essential for decarboxylation of phenylacrylic acids; homolog of E. coli UbiD; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"
>YDR540C IRC4 SGDID:S000002948, Chr IV from 1517675-1517136, reverse complement, Verified ORF, "Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus"
>YDR541C YDR541C SGDID:S000002949, Chr IV from 1520698-1519664, reverse complement, Uncharacterized ORF, "Putative dihydrokaempferol 4-reductase"
>YDR542W PAU10 SGDID:S000002950, Chr IV from 1523249-1523611, Verified ORF, "Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions"
>YDR543C YDR543C SGDID:S000002951, Chr IV from 1524933-1524634, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YDR544C YDR544C SGDID:S000002952, Chr IV from 1525523-1525095, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YDR545C-A YDR545C-A SGDID:S000028617, Chr IV from 1531342-1530863, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF YRF1-1/YDR545W"
>YDR545W YRF1-1 SGDID:S000002953, Chr IV from 1526321-1531711, Verified ORF, "Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p"
>YEL001C IRC22 SGDID:S000000727, Chr V from 150978-150301, reverse complement, Verified ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci"
>YEL002C WBP1 SGDID:S000000728, Chr V from 150014-148722, reverse complement, Verified ORF, "Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum"
>YEL003W GIM4 SGDID:S000000729, Chr V from 148176-148194,148283-148599, Verified ORF, "Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it"
>YEL004W YEA4 SGDID:S000000730, Chr V from 146951-147979, Verified ORF, "Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER"
>YEL005C VAB2 SGDID:S000000731, Chr V from 146755-145907, reverse complement, Verified ORF, "Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter"
>YEL006W YEA6 SGDID:S000000732, Chr V from 144327-145334, Verified ORF, "Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog"
>YEL007W YEL007W SGDID:S000000733, Chr V from 141892-143892, Uncharacterized ORF, "Putative protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1)"
>YEL008C-A YEL008C-A SGDID:S000028618, Chr V from 140818-140726, reverse complement, Dubious ORF, "Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YEL008W YEL008W SGDID:S000000734, Chr V from 140512-140892, Dubious ORF, "Hypothetical protein predicted to be involved in metabolism"
>YEL009C GCN4 SGDID:S000000735, Chr V from 139763-138918, reverse complement, Verified ORF, "Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels"
>YEL009C-A YEL009C-A SGDID:S000028741, Chr V from 136778-136371, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YEL010W YEL010W SGDID:S000000736, Chr V from 136279-136629, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YEL011W GLC3 SGDID:S000000737, Chr V from 133120-135234, Verified ORF, "Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern"
>YEL012W UBC8 SGDID:S000000738, Chr V from 131772-131776,131900-132551, Verified ORF, "Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro"
>YEL013W VAC8 SGDID:S000000739, Chr V from 128825-130561, Verified ORF, "Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions"
>YEL014C YEL014C SGDID:S000000740, Chr V from 128608-128303, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YEL015W EDC3 SGDID:S000000741, Chr V from 126629-128284, Verified ORF, "Non-essential conserved protein of unknown function, plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies"
>YEL016C NPP2 SGDID:S000000742, Chr V from 126218-124737, reverse complement, Verified ORF, "Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation"
>YEL017C-A PMP2 SGDID:S000002103, Chr V from 122929-122798, reverse complement, Verified ORF, "Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; nearly identical to PMP1"
>YEL017W GTT3 SGDID:S000000743, Chr V from 123657-124670, Verified ORF, "Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery"
>YEL018C-A YEL018C-A SGDID:S000028742, Chr V from 121988-121455, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YEL018W EAF5 SGDID:S000000744, Chr V from 121471-122310, Verified ORF, "Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex"
>YEL019C MMS21 SGDID:S000000745, Chr V from 121301-120498, reverse complement, Verified ORF, "SUMO ligase involved in chromosomal organization and DNA repair; essential subunit of the Mms21-Smc5-Smc6 complex; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination"
>YEL020C YEL020C SGDID:S000000746, Chr V from 120299-118617, reverse complement, Uncharacterized ORF, "Hypothetical protein with low sequence identity to Pdc1p"
>YEL020C-B YEL020C-B SGDID:S000028544, Chr V from 117380-117183, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene YEL020W-A; identified by fungal homology and RT-PCR"
>YEL020W-A TIM9 SGDID:S000007256, Chr V from 117211-117474, Verified ORF, "Essential protein of the mitochondrial intermembrane space, forms a complex with Tim10p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane"
>YEL021W URA3 SGDID:S000000747, Chr V from 116167-116970, Verified ORF, "Orotidine-5'-phosphate (OMP) decarboxylase, catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines, converting OMP into uridine monophosphate (UMP); converts 5-FOA into 5-fluorouracil, a toxic compound"
>YEL022W GEA2 SGDID:S000000748, Chr V from 111421-115800, Verified ORF, "Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea1p"
>YEL023C YEL023C SGDID:S000000749, Chr V from 110552-108504, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene"
>YEL024W RIP1 SGDID:S000000750, Chr V from 107260-107907, Verified ORF, "Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration"
>YEL025C YEL025C SGDID:S000000751, Chr V from 106147-102581, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus"
>YEL026W SNU13 SGDID:S000000752, Chr V from 101943-102323, Verified ORF, "RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein"
>YEL027W VMA3 SGDID:S000000753, Chr V from 100769-101251, Verified ORF, "Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis"
>YEL028W YEL028W SGDID:S000000754, Chr V from 98668-99129, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YEL029C BUD16 SGDID:S000000755, Chr V from 97796-96858, reverse complement, Verified ORF, "Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK)"
>YEL030C-A YEL030C-A SGDID:S000028619, Chr V from 94897-94583, reverse complement, Dubious ORF, "Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YEL030W ECM10 SGDID:S000000756, Chr V from 94644-96578, Verified ORF, "Heat shock protein of the Hsp70 family, localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations"
>YEL031W SPF1 SGDID:S000000757, Chr V from 90258-93905, Verified ORF, "P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1"
>YEL032C-A YEL032C-A SGDID:S000028620, Chr V from 87201-87040, reverse complement, Dubious ORF, "Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YEL032W MCM3 SGDID:S000000758, Chr V from 86937-89852, Verified ORF, "Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex"
>YEL033W MTC7 SGDID:S000000759, Chr V from 86179-86598, Uncharacterized ORF, "Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant"
>YEL034C-A YEL034C-A SGDID:S000028743, Chr V from 86215-85613, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; completely overlaps HYP2/YEL034W, a verified gene that encodes eiF-5A"
>YEL034W HYP2 SGDID:S000000760, Chr V from 85676-86149, Verified ORF, "Translation elongation factor eIF-5A, previously thought to function in translation initiation; similar to and functionally redundant with Anb1p; structural homolog of bacterial EF-P; undergoes an essential hypusination modification"
>YEL035C UTR5 SGDID:S000000761, Chr V from 85545-85045, reverse complement, Uncharacterized ORF, "Protein of unknown function; transcription may be regulated by Gcr1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions"
>YEL036C ANP1 SGDID:S000000762, Chr V from 84552-83050, reverse complement, Verified ORF, "Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol"
>YEL037C RAD23 SGDID:S000000763, Chr V from 82603-81407, reverse complement, Verified ORF, "Protein with ubiquitin-like N terminus, subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that recognizes and binds damaged DNA; enhances protein deglycosylation activity of Png1p; homolog of human HR23A and HR23B"
>YEL038W UTR4 SGDID:S000000764, Chr V from 80462-81145, Verified ORF, "Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleus"
>YEL039C CYC7 SGDID:S000000765, Chr V from 79977-79636, reverse complement, Verified ORF, "Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration"
>YEL040W UTR2 SGDID:S000000766, Chr V from 78053-79456, Verified ORF, "Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck"
>YEL041W YEF1 SGDID:S000000767, Chr V from 75944-77431, Verified ORF, "ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; sequence similarity to Utr1p and Pos5p; overexpression complements certain pos5 phenotypes"
>YEL042W GDA1 SGDID:S000000768, Chr V from 73771-75327, Verified ORF, "Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate"
>YEL043W YEL043W SGDID:S000000769, Chr V from 70478-73348, Verified ORF, "Predicted cytoskeleton protein involved in intracellular signalling based on quantitative analysis of protein-protein interaction maps; may interact with ribosomes, based on co-purification studies; contains fibronectin type III domain fold"
>YEL044W IES6 SGDID:S000000770, Chr V from 69757-70257, Verified ORF, "Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes"
>YEL045C YEL045C SGDID:S000000771, Chr V from 69265-68840, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress"
>YEL046C GLY1 SGDID:S000000772, Chr V from 68792-67629, reverse complement, Verified ORF, "Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis"
>YEL047C YEL047C SGDID:S000000773, Chr V from 66797-65385, reverse complement, Verified ORF, "Soluble fumarate reductase, required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies"
>YEL048C TCA17 SGDID:S000000774, Chr V from 65167-64709, reverse complement, Verified ORF, "Protein that interacts with subunits of the TRAPP complex and may play a role its assembly or stability; mutation is synthetically lethal with gcs1 deletion; Sedlin_N family member; human Sedlin mutations cause the skeletal disorder SEDT"
>YEL049W PAU2 SGDID:S000000775, Chr V from 63728-64090, Verified ORF, "Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme"
>YEL050C RML2 SGDID:S000000776, Chr V from 60851-59670, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor"
>YEL050W-A YEL050W-A SGDID:S000028545, Chr V from 59549-59740, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR"
>YEL051W VMA8 SGDID:S000000777, Chr V from 58378-59148, Verified ORF, "Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis"
>YEL052W AFG1 SGDID:S000000778, Chr V from 56571-58100, Verified ORF, "Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain"
>YEL053C MAK10 SGDID:S000000779, Chr V from 56102-53901, reverse complement, Verified ORF, "Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible"
>YEL053W-A YEL053W-A SGDID:S000028744, Chr V from 52908-53255, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YEL054C"
>YEL054C RPL12A SGDID:S000000780, Chr V from 53218-52721, reverse complement, Verified ORF, "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Bp; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins"
>YEL055C POL5 SGDID:S000000781, Chr V from 51539-48471, reverse complement, Verified ORF, "DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA"
>YEL056W HAT2 SGDID:S000000782, Chr V from 47168-48373, Verified ORF, "Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing"
>YEL057C YEL057C SGDID:S000000783, Chr V from 45721-45020, reverse complement, Uncharacterized ORF, "Protein of unknown function involved in telomere maintenance; target of UME6 regulation"
>YEL058W PCM1 SGDID:S000000784, Chr V from 43252-44925, Verified ORF, "Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors"
>YEL059C-A SOM1 SGDID:S000002954, Chr V from 42624-42400, reverse complement, Verified ORF, "Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs"
>YEL059W HHY1 SGDID:S000000785, Chr V from 42652-42960, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein; mutant is hypersensitive to hygromycin B indicative of defects in vacuolar trafficking"
>YEL060C PRB1 SGDID:S000000786, Chr V from 41953-40046, reverse complement, Verified ORF, "Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p"
>YEL061C CIN8 SGDID:S000000787, Chr V from 39537-36535, reverse complement, Verified ORF, "Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation"
>YEL062W NPR2 SGDID:S000000788, Chr V from 34407-36254, Verified ORF, "Component of an evolutionarily conserved Npr2/3 complex that mediates downregulation of TORC1 activity in response to amino acid limitation; homolog of human NPRL2; target of Grr1p (E3 ligase); required for growth on urea and proline"
>YEL063C CAN1 SGDID:S000000789, Chr V from 33466-31694, reverse complement, Verified ORF, "Plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance"
>YEL064C AVT2 SGDID:S000000790, Chr V from 31239-29797, reverse complement, Verified ORF, "Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters"
>YEL065W SIT1 SGDID:S000000791, Chr V from 27657-29543, Verified ORF, "Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p"
>YEL066W HPA3 SGDID:S000000792, Chr V from 26667-27206, Verified ORF, "D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro"
>YEL067C YEL067C SGDID:S000000793, Chr V from 26776-26189, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YEL068C YEL068C SGDID:S000000794, Chr V from 25978-25646, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YEL069C HXT13 SGDID:S000000795, Chr V from 23231-21537, reverse complement, Verified ORF, "Hexose transporter, induced in the presence of non-fermentable carbon sources, induced by low levels of glucose, repressed by high levels of glucose"
>YEL070W DSF1 SGDID:S000000796, Chr V from 19589-21097, Uncharacterized ORF, "Deletion suppressor of mpt5 mutation"
>YEL071W DLD3 SGDID:S000000797, Chr V from 16355-17845, Verified ORF, "D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm"
>YEL072W RMD6 SGDID:S000000798, Chr V from 13720-14415, Verified ORF, "Protein required for sporulation"
>YEL073C YEL073C SGDID:S000000799, Chr V from 7553-7230, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; located adjacent to ARS503 and the telomere on the left arm of chromosome V; regulated by inositol/choline"
>YEL074W YEL074W SGDID:S000000800, Chr V from 6126-6464, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; large scale expression analysis showed an increase in mRNA accumulation in strains mutant for exosome components."
>YEL075C YEL075C SGDID:S000000801, Chr V from 5713-5345, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YEL075W-A YEL075W-A SGDID:S000002956, Chr V from 4870-5481, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YEL076C YEL076C SGDID:S000000802, Chr V from 5114-4464, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YEL076C-A YEL076C-A SGDID:S000002955, Chr V from 4322-4185,5114-4602, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YEL077C YEL077C SGDID:S000006409, Chr V from 4097-264, reverse complement, Uncharacterized ORF, "Helicase-like protein encoded within the telomeric Y' element"
>YEL077W-A YEL077W-A SGDID:S000028621, Chr V from 630-1112, Dubious ORF, "Dubious open reading frame, unlike to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YER001W MNN1 SGDID:S000000803, Chr V from 153520-155808, Verified ORF, "Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family"
>YER002W NOP16 SGDID:S000000804, Chr V from 156803-157498, Verified ORF, "Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis"
>YER003C PMI40 SGDID:S000000805, Chr V from 158994-157736,159118-159088, reverse complement, Verified ORF, "Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation"
>YER004W FMP52 SGDID:S000000806, Chr V from 159580-160275, Verified ORF, "Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation"
>YER005W YND1 SGDID:S000000807, Chr V from 160550-162442, Verified ORF, "Apyrase with wide substrate specificity, involved in preventing the inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates which are inhibitors of glycotransferases; partially redundant with Gda1p"
>YER006C-A YER006C-A SGDID:S000028745, Chr V from 164661-164344, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PAC2"
>YER006W NUG1 SGDID:S000000808, Chr V from 162723-164285, Verified ORF, "GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus"
>YER007C-A TMA20 SGDID:S000002957, Chr V from 166771-166237,166885-166875, reverse complement, Verified ORF, "Protein of unknown function that associates with ribosomes and has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1"
>YER007W PAC2 SGDID:S000000809, Chr V from 164527-166083, Verified ORF, "Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl"
>YER008C SEC3 SGDID:S000000810, Chr V from 171818-167808, reverse complement, Verified ORF, "Subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, Exo84p) which mediates targeting of post-Golgi vesicles to sites of active exocytosis; Sec3p specifically is a spatial landmark for secretion"
>YER009W NTF2 SGDID:S000000811, Chr V from 172115-172492, Verified ORF, "Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport"
>YER010C YER010C SGDID:S000000812, Chr V from 173338-172634, reverse complement, Verified ORF, "Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction"
>YER011W TIR1 SGDID:S000000813, Chr V from 175248-176012, Verified ORF, "Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking"
>YER012W PRE1 SGDID:S000000814, Chr V from 177835-178431, Verified ORF, "Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle"
>YER013W PRP22 SGDID:S000000815, Chr V from 178841-182278, Verified ORF, "DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes"
>YER014C-A BUD25 SGDID:S000007590, Chr V from 184169-183731,184700-184678, reverse complement, Verified ORF, "Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern"
>YER014W HEM14 SGDID:S000000816, Chr V from 182600-184219, Verified ORF, "Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides"
>YER015W FAA2 SGDID:S000000817, Chr V from 184541-186775, Verified ORF, "Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome"
>YER016W BIM1 SGDID:S000000818, Chr V from 188277-189311, Verified ORF, "Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally"
>YER017C AFG3 SGDID:S000000819, Chr V from 191788-189503, reverse complement, Verified ORF, "Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes"
>YER018C SPC25 SGDID:S000000820, Chr V from 192624-191959, reverse complement, Verified ORF, "Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering"
>YER019C-A SBH2 SGDID:S000002127, Chr V from 194539-194273, reverse complement, Verified ORF, "Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p"
>YER019W ISC1 SGDID:S000000821, Chr V from 192797-194230, Verified ORF, "Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance"
>YER020W GPA2 SGDID:S000000822, Chr V from 195168-196517, Verified ORF, "Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery"
>YER021W RPN3 SGDID:S000000823, Chr V from 196948-198519, Verified ORF, "Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control"
>YER022W SRB4 SGDID:S000000824, Chr V from 198812-200875, Verified ORF, "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; similar to the human MED17 gene"
>YER023C-A YER023C-A SGDID:S000028622, Chr V from 201734-201522, reverse complement, Dubious ORF, "Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene PRO3; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching"
>YER023W PRO3 SGDID:S000000825, Chr V from 201076-201936, Verified ORF, "Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis"
>YER024W YAT2 SGDID:S000000826, Chr V from 202192-204963, Verified ORF, "Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane"
>YER025W GCD11 SGDID:S000000827, Chr V from 205251-206834, Verified ORF, "Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met"
>YER026C CHO1 SGDID:S000000828, Chr V from 208474-207644, reverse complement, Verified ORF, "Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline"
>YER027C GAL83 SGDID:S000000829, Chr V from 210232-208979, reverse complement, Verified ORF, "One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain"
>YER028C MIG3 SGDID:S000000830, Chr V from 211876-210692, reverse complement, Verified ORF, "Probable transcriptional repressor involved in response to toxic agents such as hydroxyurea that inhibit ribonucleotide reductase; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes"
>YER029C SMB1 SGDID:S000000831, Chr V from 213177-212587, reverse complement, Verified ORF, "Core Sm protein Sm B; part of heteroheptameric complex (with Smd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm B and Sm B'"
>YER030W CHZ1 SGDID:S000000832, Chr V from 213437-213898, Verified ORF, "Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif"
>YER031C YPT31 SGDID:S000000833, Chr V from 214747-214076, reverse complement, Verified ORF, "Rab family GTPase, very similar to Ypt32p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi"
>YER032W FIR1 SGDID:S000000834, Chr V from 215063-217693, Verified ORF, "Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate"
>YER033C ZRG8 SGDID:S000000835, Chr V from 221287-218057, reverse complement, Verified ORF, "Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency"
>YER034W YER034W SGDID:S000000836, Chr V from 221846-222403, Uncharacterized ORF, "Putative protein of unknown function; non-essential gene; expression induced upon calcium shortage"
>YER035W EDC2 SGDID:S000000837, Chr V from 222639-223076, Verified ORF, "RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress"
>YER036C ARB1 SGDID:S000000838, Chr V from 225199-223367, reverse complement, Verified ORF, "ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p"
>YER037W PHM8 SGDID:S000000839, Chr V from 225889-226854, Verified ORF, "Protein of unknown function, expression is induced by low phosphate levels and by inactivation of Pho85p"
>YER038C KRE29 SGDID:S000000840, Chr V from 228252-226858, reverse complement, Verified ORF, "Essential subunit of the Mms21-Smc5-Smc6 complex, required for growth and DNA repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance"
>YER038W-A YER038W-A SGDID:S000028746, Chr V from 228451-228831, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria"
>YER039C HVG1 SGDID:S000000841, Chr V from 229205-228456, reverse complement, Verified ORF, "Protein of unknown function, has homology to Vrg4p"
>YER039C-A YER039C-A SGDID:S000007226, Chr V from 229481-229263, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; YER039C-A is not an essential gene"
>YER040W GLN3 SGDID:S000000842, Chr V from 229795-231987, Verified ORF, "Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source"
>YER041W YEN1 SGDID:S000000843, Chr V from 232461-234740, Verified ORF, "Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p"
>YER042W MXR1 SGDID:S000000844, Chr V from 234937-235491, Verified ORF, "Methionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan"
>YER043C SAH1 SGDID:S000000845, Chr V from 237119-235770, reverse complement, Verified ORF, "S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor"
>YER044C ERG28 SGDID:S000000846, Chr V from 238016-237570, reverse complement, Verified ORF, "Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p"
>YER044C-A MEI4 SGDID:S000001954, Chr V from 239623-238460,239774-239712, reverse complement, Verified ORF, "Meiosis-specific protein involved in double-strand break formation during meiotic recombination; required for chromosome synapsis and production of viable spores"
>YER045C ACA1 SGDID:S000000847, Chr V from 241501-240032, reverse complement, Verified ORF, "Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, may regulate transcription of genes involved in utilization of non-optimal carbon sources"
>YER046W SPO73 SGDID:S000000848, Chr V from 243180-243611, Verified ORF, "Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis"
>YER046W-A YER046W-A SGDID:S000028747, Chr V from 243700-244029, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YER047C SAP1 SGDID:S000000849, Chr V from 246503-243810, reverse complement, Verified ORF, "Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system"
>YER048C CAJ1 SGDID:S000000850, Chr V from 248157-246982, reverse complement, Verified ORF, "Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly"
>YER048W-A ISD11 SGDID:S000007237, Chr V from 250718-251002, Verified ORF, "Protein required for mitochondrial iron-sulfur cluster biosynthesis"
>YER049W TPA1 SGDID:S000000851, Chr V from 251728-253662, Verified ORF, "Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate"
>YER050C RSM18 SGDID:S000000852, Chr V from 254387-253971, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein"
>YER051W JHD1 SGDID:S000000853, Chr V from 254656-256134, Verified ORF, "JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe"
>YER052C HOM3 SGDID:S000000854, Chr V from 257958-256375, reverse complement, Verified ORF, "Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis"
>YER053C PIC2 SGDID:S000000855, Chr V from 259639-258737, reverse complement, Verified ORF, "Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature"
>YER053C-A YER053C-A SGDID:S000007523, Chr V from 261046-260933, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum"
>YER054C GIP2 SGDID:S000000856, Chr V from 263698-262052, reverse complement, Verified ORF, "Putative regulatory subunit of the protein phosphatase Glc7p, involved in glycogen metabolism; contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, and Pig2p"
>YER055C HIS1 SGDID:S000000857, Chr V from 265785-264892, reverse complement, Verified ORF, "ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control"
>YER056C FCY2 SGDID:S000000858, Chr V from 268113-266512, reverse complement, Verified ORF, "Purine-cytosine permease, mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation"
>YER056C-A RPL34A SGDID:S000002135, Chr V from 269751-269423,270185-270149, reverse complement, Verified ORF, "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Bp and has similarity to rat L34 ribosomal protein"
>YER057C HMF1 SGDID:S000000859, Chr V from 271126-270737, reverse complement, Verified ORF, "Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro"
>YER058W PET117 SGDID:S000000860, Chr V from 271768-272091, Verified ORF, "Protein required for assembly of cytochrome c oxidase"
>YER059W PCL6 SGDID:S000000861, Chr V from 272624-273886, Verified ORF, "Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding"
>YER060W FCY21 SGDID:S000000862, Chr V from 274567-276153, Verified ORF, "Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function"
>YER060W-A FCY22 SGDID:S000002958, Chr V from 276572-278164, Verified ORF, "Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function"
>YER061C CEM1 SGDID:S000000863, Chr V from 279626-278298, reverse complement, Verified ORF, "Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration"
>YER062C HOR2 SGDID:S000000864, Chr V from 280682-279930, reverse complement, Verified ORF, "One of two redundant DL-glycerol-3-phosphatases (RHR2/GPP1 encodes the other) involved in glycerol biosynthesis; induced in response to hyperosmotic stress and oxidative stress, and during the diauxic transition"
>YER063W THO1 SGDID:S000000865, Chr V from 281710-282366, Verified ORF, "Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation"
>YER064C YER064C SGDID:S000000866, Chr V from 284222-282705, reverse complement, Uncharacterized ORF, "Non-essential nuclear protein; null mutation has global effects on transcription"
>YER065C ICL1 SGDID:S000000867, Chr V from 286914-285241, reverse complement, Verified ORF, "Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose"
>YER066C-A YER066C-A SGDID:S000002959, Chr V from 292203-291703, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W"
>YER066W RRT13 SGDID:S000000868, Chr V from 290242-290799, Uncharacterized ORF, "Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription"
>YER067C-A YER067C-A SGDID:S000028748, Chr V from 292563-292240, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W"
>YER067W RGI1 SGDID:S000000869, Chr V from 292066-292551, Verified ORF, "Protein of unknown function involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion"
>YER068C-A YER068C-A SGDID:S000028749, Chr V from 295732-295301, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YER068W MOT2 SGDID:S000000870, Chr V from 293050-294813, Verified ORF, "Subunit of the CCR4-NOT complex, which has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p"
>YER069W ARG5,6 SGDID:S000000871, Chr V from 295410-298001, Verified ORF, "Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase, which catalyze the 2nd and 3rd steps in arginine biosynthesis; enzymes form a complex with Arg2p"
>YER070W RNR1 SGDID:S000000872, Chr V from 298950-301616, Verified ORF, "Major isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits"
>YER071C YER071C SGDID:S000000873, Chr V from 302327-301947, reverse complement, Uncharacterized ORF, "Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern"
>YER072W VTC1 SGDID:S000000874, Chr V from 302806-303195, Verified ORF, "Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity"
>YER073W ALD5 SGDID:S000000875, Chr V from 304030-305592, Verified ORF, "Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed"
>YER074W RPS24A SGDID:S000000876, Chr V from 306323-306325,306792-307196, Verified ORF, "Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein"
>YER074W-A YOS1 SGDID:S000007651, Chr V from 307653-307746,307849-307956,308068-308123, Verified ORF, "Integral membrane protein required for ER to Golgi transport; localized to the Golgi, the ER, and COPII vesicles; interacts with Yip1p and Yif1p"
>YER075C PTP3 SGDID:S000000877, Chr V from 311199-308413, reverse complement, Verified ORF, "Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm"
>YER076C YER076C SGDID:S000000878, Chr V from 313498-312590, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization"
>YER076W-A YER076W-A SGDID:S000028750, Chr V from 313390-313737, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER076C"
>YER077C YER077C SGDID:S000000879, Chr V from 316600-314534, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport"
>YER078C ICP55 SGDID:S000000880, Chr V from 318342-316807, reverse complement, Verified ORF, "Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family"
>YER078W-A YER078W-A SGDID:S000028546, Chr V from 318646-318810, Uncharacterized ORF, "Putative protein of unknown function; identified by fungal homology and RT-PCR"
>YER079C-A YER079C-A SGDID:S000028751, Chr V from 320240-319902, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER080W"
>YER079W YER079W SGDID:S000000881, Chr V from 318920-319552, Uncharacterized ORF, "Putative protein of unknown function"
>YER080W AIM9 SGDID:S000000882, Chr V from 319963-321846, Verified ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss"
>YER081W SER3 SGDID:S000000883, Chr V from 322686-324095, Verified ORF, "3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser33p"
>YER082C UTP7 SGDID:S000000884, Chr V from 325936-324272, reverse complement, Verified ORF, "Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA"
>YER083C GET2 SGDID:S000000885, Chr V from 327031-326174, reverse complement, Verified ORF, "Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division"
>YER084W YER084W SGDID:S000000886, Chr V from 327065-327451, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YER084W-A YER084W-A SGDID:S000028752, Chr V from 327598-328110, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YER085C YER085C SGDID:S000000887, Chr V from 328140-327619, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YER086W ILV1 SGDID:S000000888, Chr V from 328477-330207, Verified ORF, "Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation"
>YER087C-A YER087C-A SGDID:S000028753, Chr V from 332368-331817, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase"
>YER087C-B SBH1 SGDID:S000002128, Chr V from 332830-332582, reverse complement, Verified ORF, "Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2p"
>YER087W AIM10 SGDID:S000000889, Chr V from 330576-332306, Verified ORF, "Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss"
>YER088C DOT6 SGDID:S000000890, Chr V from 335188-333176, reverse complement, Verified ORF, "Protein involved in rRNA and ribosome biogenesis; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; similar to Tod6p; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation"
>YER088C-A YER088C-A SGDID:S000028754, Chr V from 336019-335696, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YER088W-B YER088W-B SGDID:S000028623, Chr V from 335927-336073, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the ORF PTC2/YER089C; identified by gene-trapping, expression analysis, and homology searching"
>YER089C PTC2 SGDID:S000000891, Chr V from 337340-335946, reverse complement, Verified ORF, "Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA checkpoint"
>YER090C-A YER090C-A SGDID:S000029725, Chr V from 338411-338322, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YER090W TRP2 SGDID:S000000892, Chr V from 337949-339472, Verified ORF, "Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p"
>YER091C MET6 SGDID:S000000893, Chr V from 342167-339864, reverse complement, Verified ORF, "Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs"
>YER091C-A YER091C-A SGDID:S000007238, Chr V from 342611-342390, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YER092W IES5 SGDID:S000000894, Chr V from 342855-343232, Verified ORF, "Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions"
>YER093C TSC11 SGDID:S000000895, Chr V from 347612-343320, reverse complement, Verified ORF, "Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain"
>YER093C-A AIM11 SGDID:S000002960, Chr V from 348201-347912,348400-348277, reverse complement, Verified ORF, "Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron"
>YER094C PUP3 SGDID:S000000896, Chr V from 349346-348729, reverse complement, Verified ORF, "Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10"
>YER095W RAD51 SGDID:S000000897, Chr V from 349980-351182, Verified ORF, "Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein"
>YER096W SHC1 SGDID:S000000898, Chr V from 351698-353236, Verified ORF, "Sporulation-specific activator of Chs3p (chitin synthase III), required for the synthesis of the chitosan layer of ascospores; has similarity to Skt5p, which activates Chs3p during vegetative growth; transcriptionally induced at alkaline pH"
>YER097W YER097W SGDID:S000000899, Chr V from 355140-355469, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YER098W UBP9 SGDID:S000000900, Chr V from 355466-357730, Verified ORF, "Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions"
>YER099C PRS2 SGDID:S000000901, Chr V from 359061-358105, reverse complement, Verified ORF, "5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes"
>YER100W UBC6 SGDID:S000000902, Chr V from 359562-360314, Verified ORF, "Ubiquitin-conjugating enzyme involved in ER-associated protein degradation; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteasome pathway"
>YER101C AST2 SGDID:S000000903, Chr V from 361794-360502, reverse complement, Verified ORF, "Protein that may have a role in targeting of plasma membrane [H+]ATPase (Pma1p) to the plasma membrane, as suggested by analysis of genetic interactions"
>YER102W RPS8B SGDID:S000000904, Chr V from 363100-363702, Verified ORF, "Protein component of the small (40S) ribosomal subunit; identical to Rps8Ap and has similarity to rat S8 ribosomal protein"
>YER103W SSA4 SGDID:S000000905, Chr V from 364589-366517, Verified ORF, "Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation"
>YER104W RTT105 SGDID:S000000906, Chr V from 366802-367428, Verified ORF, "Protein with a role in regulation of Ty1 transposition"
>YER105C NUP157 SGDID:S000000907, Chr V from 372013-367838, reverse complement, Verified ORF, "Abundant subunit of the nuclear pore complex (NPC), present on both sides of the NPC; has similarity to Nup170p; essential role, with Nup170p, in NPC assembly"
>YER106W MAM1 SGDID:S000000908, Chr V from 372326-373234, Verified ORF, "Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle"
>YER107C GLE2 SGDID:S000000909, Chr V from 374545-373448, reverse complement, Verified ORF, "Component of the Nup82 subcomplex of the nuclear pore complex; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p"
>YER107W-A YER107W-A SGDID:S000028755, Chr V from 374394-374714, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, partially overlaps verified ORF GLE2/YER107C"
>YER109C FLO8 SGDID:S000000911, Chr V from 377614-375215, reverse complement, Verified ORF, "Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene"
>YER110C KAP123 SGDID:S000000912, Chr V from 382103-378762, reverse complement, Verified ORF, "Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1"
>YER111C SWI4 SGDID:S000000913, Chr V from 385876-382595, reverse complement, Verified ORF, "DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair"
>YER112W LSM4 SGDID:S000000914, Chr V from 387232-387795, Verified ORF, "Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA"
>YER113C TMN3 SGDID:S000000915, Chr V from 390052-387932, reverse complement, Verified ORF, "Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation"
>YER114C BOI2 SGDID:S000000916, Chr V from 393712-390590, reverse complement, Verified ORF, "Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain"
>YER115C SPR6 SGDID:S000000917, Chr V from 394867-394292, reverse complement, Verified ORF, "Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation"
>YER116C SLX8 SGDID:S000000918, Chr V from 396172-395348, reverse complement, Verified ORF, "Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain"
>YER117W RPL23B SGDID:S000000919, Chr V from 396769-396810,397282-397653, Verified ORF, "Protein component of the large (60S) ribosomal subunit, identical to Rpl23Ap and has similarity to E. coli L14 and rat L23 ribosomal proteins"
>YER118C SHO1 SGDID:S000000920, Chr V from 399055-397952, reverse complement, Verified ORF, "Transmembrane osmosensor, participates in activation of both the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway"
>YER119C AVT6 SGDID:S000000921, Chr V from 400842-399496, reverse complement, Verified ORF, "Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation"
>YER119C-A YER119C-A SGDID:S000002961, Chr V from 401238-400867, reverse complement, Dubious ORF, "Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene SCS2"
>YER120W SCS2 SGDID:S000000922, Chr V from 401135-401869, Verified ORF, "Integral ER membrane protein that regulates phospholipid metabolism via an interaction with the FFAT motif of Opi1p, also involved in telomeric silencing, disruption causes inositol auxotrophy above 34 degrees C, VAP homolog"
>YER121W YER121W SGDID:S000000923, Chr V from 402375-402719, Uncharacterized ORF, "Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy"
>YER122C GLO3 SGDID:S000000924, Chr V from 404352-402871, reverse complement, Verified ORF, "ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p"
>YER123W YCK3 SGDID:S000000925, Chr V from 404813-406387, Verified ORF, "Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway"
>YER124C DSE1 SGDID:S000000926, Chr V from 409063-407342, reverse complement, Verified ORF, "Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall"
>YER125W RSP5 SGDID:S000000927, Chr V from 410189-412618, Verified ORF, "E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes, including MVB sorting, heat shock response, transcription, and endocytosis; human homolog is involved in Liddle syndrome; mutant tolerates aneuploidy"
>YER126C NSA2 SGDID:S000000928, Chr V from 414179-413394, reverse complement, Verified ORF, "Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA"
>YER127W LCP5 SGDID:S000000929, Chr V from 414481-415554, Verified ORF, "Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus"
>YER128W YER128W SGDID:S000000930, Chr V from 415859-416470, Uncharacterized ORF, "Putative protein of unknown function"
>YER129W SAK1 SGDID:S000000931, Chr V from 417281-420709, Verified ORF, "Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome"
>YER130C YER130C SGDID:S000000932, Chr V from 422446-421115, reverse complement, Uncharacterized ORF, "Protein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; the C. Albicans homolog (MNL1) plays a role in adaptation to stress"
>YER131W RPS26B SGDID:S000000933, Chr V from 423952-424311, Verified ORF, "Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein"
>YER132C PMD1 SGDID:S000000934, Chr V from 430449-425188, reverse complement, Verified ORF, "Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions"
>YER133W GLC7 SGDID:S000000935, Chr V from 432495-432671,433197-433958, Verified ORF, "Type 1 serine/threonine protein phosphatase catalytic subunit, involved in many processes (eg: glycogen metabolism, sporulation, mitosis); accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits"
>YER133W-A YER133W-A SGDID:S000028756, Chr V from 437191-437532, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YER134C."
>YER134C YER134C SGDID:S000000936, Chr V from 437803-437267, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; non-essential gene"
>YER135C YER135C SGDID:S000000937, Chr V from 438344-437952, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene"
>YER136W GDI1 SGDID:S000000938, Chr V from 439616-440971, Verified ORF, "GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins"
>YER137C YER137C SGDID:S000000939, Chr V from 441819-441373, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YER137C-A YER137C-A SGDID:S000007402, Chr V from 449024-447702, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YER137W-A YER137W-A SGDID:S000028757, Chr V from 441575-441880, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YER138C YER138C SGDID:S000000940, Chr V from 447721-443756,449024-447723, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YER138W-A YER138W-A SGDID:S000007239, Chr V from 449474-449578, Uncharacterized ORF, "Putative protein of unknown function"
>YER139C RTR1 SGDID:S000000941, Chr V from 451243-450563, reverse complement, Verified ORF, "CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm"
>YER140W YER140W SGDID:S000000942, Chr V from 451565-453235, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; genetic interactions suggest a role in folding of ER membrane proteins"
>YER141W COX15 SGDID:S000000943, Chr V from 453459-454919, Verified ORF, "Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase"
>YER142C MAG1 SGDID:S000000944, Chr V from 456036-455146, reverse complement, Verified ORF, "3-methyl-adenine DNA glycosylase involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired"
>YER143W DDI1 SGDID:S000000945, Chr V from 456319-457605, Verified ORF, "DNA damage-inducible v-SNARE binding protein, contains a ubiquitin-associated (UBA) domain, may act as a negative regulator of constitutive exocytosis, may play a role in S-phase checkpoint control"
>YER144C UBP5 SGDID:S000000946, Chr V from 460223-457806, reverse complement, Verified ORF, "Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck"
>YER145C FTR1 SGDID:S000000947, Chr V from 461740-460526, reverse complement, Verified ORF, "High affinity iron permease involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron"
>YER145C-A YER145C-A SGDID:S000028758, Chr V from 462823-462386, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF LSM5/YER146W"
>YER146W LSM5 SGDID:S000000948, Chr V from 462585-462866, Verified ORF, "Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA"
>YER147C SCC4 SGDID:S000000949, Chr V from 464842-462968, reverse complement, Verified ORF, "Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX"
>YER147C-A YER147C-A SGDID:S000028759, Chr V from 465613-465203, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YER148W SPT15 SGDID:S000000950, Chr V from 465303-466025, Verified ORF, "TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability"
>YER148W-A YER148W-A SGDID:S000028760, Chr V from 466185-466763, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YER149C PEA2 SGDID:S000000951, Chr V from 467470-466208, reverse complement, Verified ORF, "Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth"
>YER150W SPI1 SGDID:S000000952, Chr V from 468370-468816, Verified ORF, "GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p"
>YER151C UBP3 SGDID:S000000953, Chr V from 472424-469686, reverse complement, Verified ORF, "Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between the ER and Golgi; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin; also has mRNA binding activity"
>YER152C YER152C SGDID:S000000954, Chr V from 473988-472657, reverse complement, Verified ORF, "Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene"
>YER152W-A YER152W-A SGDID:S000028761, Chr V from 473485-474051, Dubious ORF, "Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YER153C PET122 SGDID:S000000955, Chr V from 474805-474041, reverse complement, Verified ORF, "Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane"
>YER154W OXA1 SGDID:S000000956, Chr V from 475020-476228, Verified ORF, "Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals"
>YER155C BEM2 SGDID:S000000957, Chr V from 482848-476345, reverse complement, Verified ORF, "Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence"
>YER156C YER156C SGDID:S000000958, Chr V from 484341-483325, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1"
>YER157W COG3 SGDID:S000000959, Chr V from 484788-487193, Verified ORF, "Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments"
>YER158C YER158C SGDID:S000000960, Chr V from 490578-488857, reverse complement, Uncharacterized ORF, "Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p"
>YER158W-A YER158W-A SGDID:S000028624, Chr V from 491487-491702, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YER159C BUR6 SGDID:S000000961, Chr V from 491958-491530, reverse complement, Verified ORF, "Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha"
>YER159C-A YER159C-A SGDID:S000007403, Chr V from 498124-496802, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YER160C YER160C SGDID:S000000962, Chr V from 496821-492856,498124-496823, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YER161C SPT2 SGDID:S000000963, Chr V from 500348-499347, reverse complement, Verified ORF, "Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins"
>YER162C RAD4 SGDID:S000000964, Chr V from 502894-500630, reverse complement, Verified ORF, "Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human XPC protein"
>YER163C YER163C SGDID:S000000965, Chr V from 503782-503084, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle; weak similarity to bacterial cation transport protein"
>YER164W CHD1 SGDID:S000000966, Chr V from 505392-509798, Verified ORF, "Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes"
>YER165C-A YER165C-A SGDID:S000028762, Chr V from 512983-512627, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene DNF1/YER166W"
>YER165W PAB1 SGDID:S000000967, Chr V from 510373-512106, Verified ORF, "Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G"
>YER166W DNF1 SGDID:S000000968, Chr V from 512744-517459, Verified ORF, "Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase"
>YER167W BCK2 SGDID:S000000969, Chr V from 518216-520771, Verified ORF, "Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations"
>YER168C CCA1 SGDID:S000000970, Chr V from 522669-521029, reverse complement, Verified ORF, "ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites"
>YER169W RPH1 SGDID:S000000971, Chr V from 523369-525759, Verified ORF, "JmjC domain-containing histone demethylase which can specifically demethylate H3K36 tri- and dimethyl modification states; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway"
>YER170W ADK2 SGDID:S000000972, Chr V from 525974-526651, Verified ORF, "Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background"
>YER171W RAD3 SGDID:S000000973, Chr V from 527082-529418, Verified ORF, "5' to 3' DNA helicase, involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance"
>YER172C BRR2 SGDID:S000000974, Chr V from 536021-529530, reverse complement, Verified ORF, "RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD"
>YER172C-A YER172C-A SGDID:S000028763, Chr V from 536655-536275, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YER173W RAD24 SGDID:S000000975, Chr V from 536300-538279, Verified ORF, "Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein"
>YER174C GRX4 SGDID:S000000976, Chr V from 539168-538434, reverse complement, Verified ORF, "Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; mutant has increased aneuploidy tolerance"
>YER175C TMT1 SGDID:S000000977, Chr V from 540363-539464, reverse complement, Verified ORF, "Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle"
>YER175W-A YER175W-A SGDID:S000028625, Chr V from 540650-540814, Uncharacterized ORF, "Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YER176W ECM32 SGDID:S000000978, Chr V from 541690-545055, Verified ORF, "DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes"
>YER177W BMH1 SGDID:S000000979, Chr V from 545611-546414, Verified ORF, "14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling"
>YER178W PDA1 SGDID:S000000980, Chr V from 546817-548079, Verified ORF, "E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose"
>YER179W DMC1 SGDID:S000000981, Chr V from 548421-548552,548645-549517, Verified ORF, "Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein"
>YER180C ISC10 SGDID:S000000982, Chr V from 550527-549724, reverse complement, Verified ORF, "Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells"
>YER180C-A SLO1 SGDID:S000028437, Chr V from 551122-550865, reverse complement, Verified ORF, "Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO"
>YER181C YER181C SGDID:S000000983, Chr V from 551796-551473, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies"
>YER182W FMP10 SGDID:S000000984, Chr V from 552525-553259, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YER183C FAU1 SGDID:S000000985, Chr V from 553969-553334, reverse complement, Verified ORF, "5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis"
>YER184C YER184C SGDID:S000000986, Chr V from 558680-556296, reverse complement, Uncharacterized ORF, "Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source"
>YER185W PUG1 SGDID:S000000987, Chr V from 559454-560365, Verified ORF, "Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins"
>YER186C YER186C SGDID:S000000988, Chr V from 562625-561705, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YER187W YER187W SGDID:S000000989, Chr V from 566230-566655, Uncharacterized ORF, "Putative protein of unknown function; induced in respiratory-deficient cells"
>YER188C-A YER188C-A SGDID:S000028764, Chr V from 569907-569608, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YER188W YER188W SGDID:S000000990, Chr V from 568040-568759, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p"
>YER189W YER189W SGDID:S000000991, Chr V from 571155-571523, Uncharacterized ORF, "Putative protein of unknown function"
>YER190C-A YER190C-A SGDID:S000028626, Chr V from 575379-574804, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF YRF1-2/YER190W; identified by gene-trapping, expression analysis, and homology"
>YER190C-B YER190C-B SGDID:S000028627, Chr V from 576162-575680, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YER190W YRF1-2 SGDID:S000000992, Chr V from 571480-576525, Verified ORF, "Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p; induced by treatment with 8-methoxypsoralen and UVA irradiation"
>YFL001W DEG1 SGDID:S000001895, Chr VI from 147131-148459, Verified ORF, "tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability"
>YFL002C SPB4 SGDID:S000001894, Chr VI from 146934-145114, reverse complement, Verified ORF, "Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients"
>YFL002W-A YFL002W-A SGDID:S000002962, Chr VI from 138204-139496,139498-143517, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YFL002W-B YFL002W-B SGDID:S000007404, Chr VI from 138204-139520, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YFL003C MSH4 SGDID:S000001891, Chr VI from 137157-134521, reverse complement, Verified ORF, "Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein"
>YFL004W VTC2 SGDID:S000001890, Chr VI from 131810-134296, Verified ORF, "Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion"
>YFL005W SEC4 SGDID:S000001889, Chr VI from 130334-130981, Verified ORF, "Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane"
>YFL007W BLM10 SGDID:S000001887, Chr VI from 123479-129910, Verified ORF, "Proteasome activator subunit; found in association with core particles, with and without the 19S regulatory particle; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200"
>YFL008W SMC1 SGDID:S000001886, Chr VI from 119429-123106, Verified ORF, "Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure"
>YFL009W CDC4 SGDID:S000001885, Chr VI from 116145-118484, Verified ORF, "F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p"
>YFL010C WWM1 SGDID:S000001884, Chr VI from 115743-115108, reverse complement, Verified ORF, "WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1"
>YFL010W-A AUA1 SGDID:S000001955, Chr VI from 114990-115274, Verified ORF, "Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease"
>YFL011W HXT10 SGDID:S000001883, Chr VI from 112345-113985, Verified ORF, "Putative hexose transporter, expressed at low levels and expression is repressed by glucose"
>YFL012W YFL012W SGDID:S000001882, Chr VI from 110647-111093, Uncharacterized ORF, "Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin"
>YFL012W-A YFL012W-A SGDID:S000002964, Chr VI from 109810-110184, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene IES1/YFL013C"
>YFL013C IES1 SGDID:S000001881, Chr VI from 109930-107852, reverse complement, Verified ORF, "Subunit of the INO80 chromatin remodeling complex"
>YFL013W-A YFL013W-A SGDID:S000028628, Chr VI from 107799-108602, Dubious ORF, "Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching"
>YFL014W HSP12 SGDID:S000001880, Chr VI from 107256-107585, Verified ORF, "Plasma membrane localized protein that protects membranes from desiccation; induced by heat shock, oxidative stress, osmostress, stationary phase entry, glucose depletion, oleate and alcohol; regulated by the HOG and Ras-Pka pathways"
>YFL015C YFL015C SGDID:S000001879, Chr VI from 106963-106469, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene"
>YFL015W-A YFL015W-A SGDID:S000028765, Chr VI from 106415-106732, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YFL016C MDJ1 SGDID:S000001878, Chr VI from 106236-104701, reverse complement, Verified ORF, "Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones"
>YFL017C GNA1 SGDID:S000001877, Chr VI from 104462-103983, reverse complement, Verified ORF, "Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA"
>YFL017W-A SMX2 SGDID:S000002965, Chr VI from 103699-103932, Verified ORF, "Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G"
>YFL018C LPD1 SGDID:S000001876, Chr VI from 103127-101628, reverse complement, Verified ORF, "Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes"
>YFL019C YFL019C SGDID:S000001875, Chr VI from 100605-100252, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene"
>YFL020C PAU5 SGDID:S000001874, Chr VI from 99599-99231, reverse complement, Verified ORF, "Member of the seripauperin multigene family encoded mainly in subtelomeric regions; induced during alcoholic fermentation; induced by low temperature and also by anaerobic conditions; negatively regulated by oxygen and repressed by heme"
>YFL021C-A YFL021C-A SGDID:S000028766, Chr VI from 96615-95761, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YFL021W GAT1 SGDID:S000001873, Chr VI from 95966-97498, Verified ORF, "Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p"
>YFL022C FRS2 SGDID:S000001872, Chr VI from 95010-93499, reverse complement, Verified ORF, "Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar"
>YFL023W BUD27 SGDID:S000001871, Chr VI from 90986-93376, Verified ORF, "Unconventional prefoldin protein involved in translation initiation; mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor; diploid mutants show random budding"
>YFL024C EPL1 SGDID:S000001870, Chr VI from 90345-87847, reverse complement, Verified ORF, "Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb"
>YFL025C BST1 SGDID:S000001869, Chr VI from 87234-84145, reverse complement, Verified ORF, "GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules"
>YFL026W STE2 SGDID:S000001868, Chr VI from 82580-83875, Verified ORF, "Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells"
>YFL027C GYP8 SGDID:S000001867, Chr VI from 81912-80419, reverse complement, Verified ORF, "GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport"
>YFL028C CAF16 SGDID:S000001866, Chr VI from 80213-79344, reverse complement, Verified ORF, "Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator"
>YFL029C CAK1 SGDID:S000001865, Chr VI from 79161-78055, reverse complement, Verified ORF, "Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases"
>YFL030W AGX1 SGDID:S000001864, Chr VI from 76831-77988, Verified ORF, "Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases"
>YFL031C-A YFL031C-A SGDID:S000028629, Chr VI from 76115-76014, reverse complement, Dubious ORF, "Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps HAC1/YFL031W; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YFL031W HAC1 SGDID:S000001863, Chr VI from 75179-75839,76092-76147, Verified ORF, "Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis"
>YFL032W YFL032W SGDID:S000001862, Chr VI from 74872-75192, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene"
>YFL033C RIM15 SGDID:S000001861, Chr VI from 74427-69115, reverse complement, Verified ORF, "Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase"
>YFL034C-A RPL22B SGDID:S000006436, Chr VI from 64599-64243,64932-64921, reverse complement, Verified ORF, "Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Ap and to rat L22 ribosomal protein"
>YFL034C-B MOB2 SGDID:S000001859, Chr VI from 63859-63016,63993-63974, reverse complement, Verified ORF, "Component of the RAM signaling network, that activates the Cbk1p kinase, thereby facilitating the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p"
>YFL034W YFL034W SGDID:S000001860, Chr VI from 65477-68698, Uncharacterized ORF, "Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk"
>YFL036W RPO41 SGDID:S000001858, Chr VI from 58782-62837, Verified ORF, "Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition"
>YFL037W TUB2 SGDID:S000001857, Chr VI from 56336-57709, Verified ORF, "Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules"
>YFL038C YPT1 SGDID:S000001856, Chr VI from 55986-55366, reverse complement, Verified ORF, "Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)"
>YFL039C ACT1 SGDID:S000001855, Chr VI from 54377-53260,54696-54687, reverse complement, Verified ORF, "Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions"
>YFL040W YFL040W SGDID:S000001854, Chr VI from 51350-52972, Uncharacterized ORF, "Putative transporter, member of the sugar porter family; YFL040W is not an essential gene"
>YFL041W FET5 SGDID:S000001853, Chr VI from 49139-51007, Verified ORF, "Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport"
>YFL041W-A YFL041W-A SGDID:S000028547, Chr VI from 48734-48925, Uncharacterized ORF, "Putative protein of unknown function; identified by fungal homology and RT-PCR"
>YFL042C YFL042C SGDID:S000001852, Chr VI from 47744-45720, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; YFL042C is not an essential gene"
>YFL044C OTU1 SGDID:S000001850, Chr VI from 45560-44655, reverse complement, Verified ORF, "Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family"
>YFL045C SEC53 SGDID:S000001849, Chr VI from 44392-43628, reverse complement, Verified ORF, "Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen"
>YFL046W FMP32 SGDID:S000001848, Chr VI from 42815-43438, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YFL047W RGD2 SGDID:S000001847, Chr VI from 40421-42565, Verified ORF, "GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p"
>YFL048C EMP47 SGDID:S000001846, Chr VI from 40180-38843, reverse complement, Verified ORF, "Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport"
>YFL049W SWP82 SGDID:S000001845, Chr VI from 36803-38674, Verified ORF, "Member of the SWI/SNF chromatin remodeling complex in which it plays an as yet unidentified role; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p"
>YFL050C ALR2 SGDID:S000001844, Chr VI from 35848-33272, reverse complement, Verified ORF, "Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition"
>YFL051C YFL051C SGDID:S000001843, Chr VI from 30540-30058, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; YFL051C is not an essential gene"
>YFL052W YFL052W SGDID:S000001842, Chr VI from 28232-29629, Uncharacterized ORF, "Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity"
>YFL053W DAK2 SGDID:S000001841, Chr VI from 23423-25198, Verified ORF, "Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation"
>YFL054C YFL054C SGDID:S000001840, Chr VI from 22787-20847, reverse complement, Uncharacterized ORF, "Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol"
>YFL055W AGP3 SGDID:S000001839, Chr VI from 17004-18680, Verified ORF, "Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition"
>YFL056C AAD6 SGDID:S000001838, Chr VI from 15431-14793, reverse complement, Verified ORF, "Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase, involved in the oxidative stress response; expression induced in cells treated with the mycotoxin patulin"
>YFL057C AAD16 SGDID:S000001837, Chr VI from 14763-14305, reverse complement, Verified ORF, "Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role"
>YFL058W THI5 SGDID:S000001836, Chr VI from 12929-13951, Verified ORF, "Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13"
>YFL059W SNZ3 SGDID:S000001835, Chr VI from 11363-12259, Verified ORF, "Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO3"
>YFL060C SNO3 SGDID:S000001834, Chr VI from 10969-10301, reverse complement, Verified ORF, "Protein of unknown function, nearly identical to Sno2p; expression is induced before the diauxic shift and also in the absence of thiamin"
>YFL061W DDI2 SGDID:S000001833, Chr VI from 9545-10222, Uncharacterized ORF, "Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants"
>YFL062W COS4 SGDID:S000001832, Chr VI from 6426-7565, Verified ORF, "Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins"
>YFL063W YFL063W SGDID:S000001831, Chr VI from 5066-5521, Dubious ORF, "Dubious open reading frame, based on available experimental and comparative sequence data"
>YFL064C YFL064C SGDID:S000001830, Chr VI from 3846-3322, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YFL065C YFL065C SGDID:S000001829, Chr VI from 3338-3030, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation"
>YFL066C YFL066C SGDID:S000001828, Chr VI from 2615-1437, reverse complement, Uncharacterized ORF, "Helicase-like protein encoded within the telomeric Y' element; induced by treatment with 8-methoxypsoralen and UVA irradiation"
>YFL067W YFL067W SGDID:S000001827, Chr VI from 836-1363, Uncharacterized ORF, "Protein of unknown function, down-regulated at low calcium levels"
>YFL068W YFL068W SGDID:S000001826, Chr VI from 53-535, Uncharacterized ORF, "Putative protein of unknown function"
>YFR001W LOC1 SGDID:S000001897, Chr VI from 149110-149724, Verified ORF, "Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles"
>YFR002W NIC96 SGDID:S000001898, Chr VI from 150016-152535, Verified ORF, "Component of the nuclear pore complex, required for nuclear pore formation; forms a subcomplex with Nsp1p, Nup57p, and Nup49p"
>YFR003C YPI1 SGDID:S000001899, Chr VI from 153124-152657, reverse complement, Verified ORF, "Inhibitor of the type I protein phosphatase Glc7p, which is involved in regulation of a variety of metabolic processes; overproduction causes decreased cellular content of glycogen"
>YFR004W RPN11 SGDID:S000001900, Chr VI from 153393-154313, Verified ORF, "Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes"
>YFR005C SAD1 SGDID:S000001901, Chr VI from 155873-154527, reverse complement, Verified ORF, "Conserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particle"
>YFR006W YFR006W SGDID:S000001902, Chr VI from 156145-157752, Uncharacterized ORF, "Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene"
>YFR007W YFH7 SGDID:S000001903, Chr VI from 159299-160360, Verified ORF, "Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases"
>YFR008W FAR7 SGDID:S000001904, Chr VI from 160535-161200, Verified ORF, "Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p"
>YFR009W GCN20 SGDID:S000001905, Chr VI from 162488-164746, Verified ORF, "Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA"
>YFR009W-A YFR009W-A SGDID:S000028823, Chr VI from 163875-164132, Dubious ORF, "Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YFR009W; identified by expression profiling and mass spectrometry"
>YFR010W UBP6 SGDID:S000001906, Chr VI from 165067-166566, Verified ORF, "Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance"
>YFR010W-A YFR010W-A SGDID:S000028824, Chr VI from 166728-166916, Dubious ORF, "Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene YFR011C; identified by expression profiling and mass spectrometry"
>YFR011C AIM13 SGDID:S000001907, Chr VI from 167258-166746, reverse complement, Verified ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria; null mutant displays reduced respiratory growth and reduced frequency of mitochondrial genome loss"
>YFR012W YFR012W SGDID:S000001908, Chr VI from 167888-168496, Uncharacterized ORF, "Putative protein of unknown function"
>YFR012W-A YFR012W-A SGDID:S000007606, Chr VI from 169224-169310, Uncharacterized ORF, "Putative protein of unknown function; identified by homology"
>YFR013W IOC3 SGDID:S000001909, Chr VI from 169922-172285, Verified ORF, "Member of a complex (Isw1a) with Isw1p that has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; has homology to Esc8p, which is involved in silencing"
>YFR014C CMK1 SGDID:S000001910, Chr VI from 173877-172537, reverse complement, Verified ORF, "Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk2p and mammalian Cam Kinase II"
>YFR015C GSY1 SGDID:S000001911, Chr VI from 176391-174265, reverse complement, Verified ORF, "Glycogen synthase with similarity to Gsy2p, the more highly expressed yeast homolog; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase"
>YFR016C YFR016C SGDID:S000001912, Chr VI from 180743-177042, reverse complement, Verified ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene"
>YFR017C YFR017C SGDID:S000001913, Chr VI from 182861-182274, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene"
>YFR018C YFR018C SGDID:S000001914, Chr VI from 184222-183131, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YFR019W FAB1 SGDID:S000001915, Chr VI from 184502-191338, Verified ORF, "1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis"
>YFR020W YFR020W SGDID:S000001916, Chr VI from 192737-193435, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YFR021W ATG18 SGDID:S000001917, Chr VI from 194812-196314, Verified ORF, "Phosphoinositide binding protein required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein"
>YFR022W ROG3 SGDID:S000001918, Chr VI from 196833-199034, Verified ORF, "Protein that binds the ubiquitin ligase Rsp5p via its 2 PY motifs; has similarity to Rod1p; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant; proposed to regulate the endocytosis of plasma membrane proteins"
>YFR023W PES4 SGDID:S000001919, Chr VI from 199874-201709, Verified ORF, "Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation, similar to Mip6p"
>YFR024C-A LSB3 SGDID:S000002968, Chr VI from 203292-201960,203433-203387, reverse complement, Verified ORF, "Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization"
>YFR025C HIS2 SGDID:S000001921, Chr VI from 204750-203743, reverse complement, Verified ORF, "Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control"
>YFR026C ULI1 SGDID:S000001922, Chr VI from 206257-205748, reverse complement, Verified ORF, "Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response"
>YFR027W ECO1 SGDID:S000001923, Chr VI from 207452-208297, Verified ORF, "Acetyltransferase required for sister chromatid cohesion; modifies Smc3p at DNA replication forks during S-phase; modifies Mcd1p in response to double-strand DNA breaks during G2/M; mutations in human homolog ESCO2 cause Roberts syndrome"
>YFR028C CDC14 SGDID:S000001924, Chr VI from 210068-208413, reverse complement, Verified ORF, "Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit"
>YFR029W PTR3 SGDID:S000001925, Chr VI from 210937-212973, Verified ORF, "Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes"
>YFR030W MET10 SGDID:S000001926, Chr VI from 213312-216419, Verified ORF, "Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide"
>YFR031C SMC2 SGDID:S000001927, Chr VI from 220106-216594, reverse complement, Verified ORF, "Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus"
>YFR031C-A RPL2A SGDID:S000002104, Chr VI from 221267-220507,221418-221415, reverse complement, Verified ORF, "Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteins"
>YFR032C RRT5 SGDID:S000001928, Chr VI from 222959-222090, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation"
>YFR032C-A RPL29 SGDID:S000006437, Chr VI from 223437-223258, reverse complement, Verified ORF, "Protein component of the large (60S) ribosomal subunit, has similarity to rat L29 ribosomal protein; not essential for translation, but required for proper joining of the large and small ribosomal subunits and for normal translation rate"
>YFR032C-B YFR032C-B SGDID:S000028630, Chr VI from 223973-223710, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YFR033C QCR6 SGDID:S000001929, Chr VI from 224769-224326, reverse complement, Verified ORF, "Subunit 6 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1"
>YFR034C PHO4 SGDID:S000001930, Chr VI from 225958-225020, reverse complement, Verified ORF, "Basic helix-loop-helix (bHLH) transcription factor of the myc-family; binds cooperatively with Pho2p to the PHO5 promoter; function is regulated by phosphorylation at multiple sites and by phosphate availability"
>YFR034W-A YFR034W-A SGDID:S000028631, Chr VI from 226022-226309, Dubious ORF, "Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YFR035C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching"
>YFR035C YFR035C SGDID:S000001931, Chr VI from 226465-226121, reverse complement, Uncharacterized ORF, "Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein"
>YFR036W CDC26 SGDID:S000001932, Chr VI from 226963-227337, Verified ORF, "Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition"
>YFR036W-A YFR036W-A SGDID:S000028767, Chr VI from 227451-228101, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene RSC8"
>YFR037C RSC8 SGDID:S000001933, Chr VI from 229186-227513, reverse complement, Verified ORF, "Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters"
>YFR038W IRC5 SGDID:S000001934, Chr VI from 229380-231941, Verified ORF, "Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci"
>YFR039C YFR039C SGDID:S000001935, Chr VI from 233544-232012, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces"
>YFR040W SAP155 SGDID:S000001936, Chr VI from 234242-237250, Verified ORF, "Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p"
>YFR041C ERJ5 SGDID:S000001937, Chr VI from 238255-237368, reverse complement, Verified ORF, "Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response"
>YFR042W KEG1 SGDID:S000001938, Chr VI from 238458-239060, Verified ORF, "Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability"
>YFR043C IRC6 SGDID:S000001939, Chr VI from 239827-239114, reverse complement, Verified ORF, "Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci"
>YFR044C DUG1 SGDID:S000001940, Chr VI from 241437-239992, reverse complement, Verified ORF, "Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)"
>YFR045W YFR045W SGDID:S000001941, Chr VI from 241998-242009,242082-242999, Uncharacterized ORF, "Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white"
>YFR046C CNN1 SGDID:S000001942, Chr VI from 244159-243074, reverse complement, Verified ORF, "Kinetochore protein of unknown function; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by both Clb5-Cdk1 and, to a lesser extent, Clb2-Cdk1."
>YFR047C BNA6 SGDID:S000001943, Chr VI from 245166-244279, reverse complement, Verified ORF, "Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p"
>YFR048W RMD8 SGDID:S000001944, Chr VI from 246146-248134, Verified ORF, "Cytosolic protein required for sporulation"
>YFR049W YMR31 SGDID:S000001945, Chr VI from 248523-248894, Verified ORF, "Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36"
>YFR050C PRE4 SGDID:S000001946, Chr VI from 249866-249066, reverse complement, Verified ORF, "Beta 7 subunit of the 20S proteasome"
>YFR051C RET2 SGDID:S000001947, Chr VI from 251803-250163, reverse complement, Verified ORF, "Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER"
>YFR052C-A YFR052C-A SGDID:S000028768, Chr VI from 253734-253429, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YFR052W RPN12 SGDID:S000001948, Chr VI from 252505-253329, Verified ORF, "Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p"
>YFR053C HXK1 SGDID:S000001949, Chr VI from 255049-253592, reverse complement, Verified ORF, "Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p"
>YFR054C YFR054C SGDID:S000001950, Chr VI from 259433-258855, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YFR055W IRC7 SGDID:S000001952, Chr VI from 264204-265226, Uncharacterized ORF, "Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner"
>YFR056C YFR056C SGDID:S000001951, Chr VI from 264325-263957, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W"
>YFR057W YFR057W SGDID:S000001953, Chr VI from 269061-269516, Uncharacterized ORF, "Putative protein of unknown function"
>YGL001C ERG26 SGDID:S000002969, Chr VII from 496502-495453, reverse complement, Verified ORF, "C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis"
>YGL002W ERP6 SGDID:S000002970, Chr VII from 494517-495167, Verified ORF, "Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YGL003C CDH1 SGDID:S000002971, Chr VII from 494174-492474, reverse complement, Verified ORF, "Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p"
>YGL004C RPN14 SGDID:S000002972, Chr VII from 491956-490703, reverse complement, Verified ORF, "Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p"
>YGL005C COG7 SGDID:S000002973, Chr VII from 490547-489708, reverse complement, Verified ORF, "Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments"
>YGL006W PMC1 SGDID:S000002974, Chr VII from 485921-489442, Verified ORF, "Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a"
>YGL006W-A YGL006W-A SGDID:S000028769, Chr VII from 485423-485533, Uncharacterized ORF, "Putative protein of unknown function; identified by SAGE"
>YGL007C-A YGL007C-A SGDID:S000028632, Chr VII from 483027-482941, reverse complement, Uncharacterized ORF, "Putative protein of unknown function, identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; deletion exhibits slow-growth phenotype; computationally predicted to have a role in cell budding"
>YGL007W BRP1 SGDID:S000002975, Chr VII from 483260-483637, Dubious ORF, "Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1"
>YGL008C PMA1 SGDID:S000002976, Chr VII from 482666-479910, reverse complement, Verified ORF, "Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; part of the P2 subgroup of cation-transporting ATPases"
>YGL009C LEU1 SGDID:S000002977, Chr VII from 478652-476313, reverse complement, Verified ORF, "Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway"
>YGL010W YGL010W SGDID:S000002978, Chr VII from 475545-476069, Uncharacterized ORF, "Putative protein of unknown function; YGL010W is not an essential gene"
>YGL011C SCL1 SGDID:S000002979, Chr VII from 475247-474489, reverse complement, Verified ORF, "Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria"
>YGL012W ERG4 SGDID:S000002980, Chr VII from 472855-474276, Verified ORF, "C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol"
>YGL013C PDR1 SGDID:S000002981, Chr VII from 472298-469092, reverse complement, Verified ORF, "Zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes"
>YGL014C-A YGL014C-A SGDID:S000028825, Chr VII from 466398-466237, reverse complement, Dubious ORF, "Dubious open reading frame, unlikely to encode a functional protein; identified by expression profiling and mass spectrometry"
>YGL014W PUF4 SGDID:S000002982, Chr VII from 466141-468807, Verified ORF, "Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors"
>YGL015C YGL015C SGDID:S000002983, Chr VII from 465435-465043, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; null mutants accumulate cargo in the Golgi"
>YGL016W KAP122 SGDID:S000002984, Chr VII from 461666-464911, Verified ORF, "Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance"
>YGL017W ATE1 SGDID:S000002985, Chr VII from 459854-461365, Verified ORF, "Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway"
>YGL018C JAC1 SGDID:S000002986, Chr VII from 459664-459110, reverse complement, Verified ORF, "Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix"
>YGL019W CKB1 SGDID:S000002987, Chr VII from 458156-458992, Verified ORF, "Beta regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB2, the many substrates include transcription factors and all RNA polymerases"
>YGL020C GET1 SGDID:S000002988, Chr VII from 457870-457163, reverse complement, Verified ORF, "Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance"
>YGL021W ALK1 SGDID:S000002989, Chr VII from 454785-457067, Verified ORF, "Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk2p and to mammalian haspins"
>YGL022W STT3 SGDID:S000002990, Chr VII from 452404-454560, Verified ORF, "Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; forms a subcomplex with Ost3p and Ost4p and is directly involved in catalysis"
>YGL023C PIB2 SGDID:S000002991, Chr VII from 452104-450197, reverse complement, Verified ORF, "Protein binding phosphatidylinositol 3-phosphate, involved in telomere-proximal repression of gene expression; similar to Fab1 and Vps27"
>YGL024W YGL024W SGDID:S000002992, Chr VII from 449788-450123, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF PGD1/YGL025C"
>YGL025C PGD1 SGDID:S000002993, Chr VII from 449957-448764, reverse complement, Verified ORF, "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor"
>YGL026C TRP5 SGDID:S000002994, Chr VII from 448535-446412, reverse complement, Verified ORF, "Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis"
>YGL027C CWH41 SGDID:S000002995, Chr VII from 446143-443642, reverse complement, Verified ORF, "Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress"
>YGL028C SCW11 SGDID:S000002996, Chr VII from 442909-441281, reverse complement, Verified ORF, "Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p"
>YGL029W CGR1 SGDID:S000002997, Chr VII from 440063-440425, Verified ORF, "Protein involved in nucleolar integrity and processing of the pre-rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress"
>YGL030W RPL30 SGDID:S000002998, Chr VII from 439091-439093,439324-439638, Verified ORF, "Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript"
>YGL031C RPL24A SGDID:S000002999, Chr VII from 437934-437467, reverse complement, Verified ORF, "Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate"
>YGL032C AGA2 SGDID:S000003000, Chr VII from 436833-436570, reverse complement, Verified ORF, "Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds"
>YGL033W HOP2 SGDID:S000003001, Chr VII from 435625-435679,435750-436351, Verified ORF, "Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair"
>YGL034C YGL034C SGDID:S000003002, Chr VII from 433579-433214, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YGL035C MIG1 SGDID:S000003003, Chr VII from 433062-431548, reverse complement, Verified ORF, "Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase"
>YGL036W YGL036W SGDID:S000003004, Chr VII from 428601-431330, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YGL036W is not an essential gene"
>YGL037C PNC1 SGDID:S000003005, Chr VII from 427947-427297, reverse complement, Verified ORF, "Nicotinamidase that converts nicotinamide to nicotinic acid as part of the NAD(+) salvage pathway, required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span"
>YGL038C OCH1 SGDID:S000003006, Chr VII from 426804-425362, reverse complement, Verified ORF, "Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins"
>YGL039W YGL039W SGDID:S000003007, Chr VII from 423961-425007, Verified ORF, "Oxidoreductase shown to reduce carbonyl compounds to chiral alcohols"
>YGL040C HEM2 SGDID:S000003008, Chr VII from 420555-419527, reverse complement, Verified ORF, "Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus"
>YGL041C YGL041C SGDID:S000003009, Chr VII from 419225-419022, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YGL041C-B YGL041C-B SGDID:S000028548, Chr VII from 418886-418704, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by fungal homology and RT-PCR"
>YGL041W-A YGL041W-A SGDID:S000028826, Chr VII from 418825-419289, Uncharacterized ORF, "Putative protein of unknown function, conserved in fungi; identified by expression profiling and mass spectrometry"
>YGL042C YGL042C SGDID:S000003010, Chr VII from 418593-418288, reverse complement, Dubious ORF, "Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1"
>YGL043W DST1 SGDID:S000003011, Chr VII from 417483-418412, Verified ORF, "General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites"
>YGL044C RNA15 SGDID:S000003012, Chr VII from 417036-416146, reverse complement, Verified ORF, "Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p"
>YGL045W RIM8 SGDID:S000003013, Chr VII from 414102-415730, Verified ORF, "Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family"
>YGL047W ALG13 SGDID:S000003015, Chr VII from 411552-412160, Verified ORF, "Catalytic component of UDP-GlcNAc transferase, required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases"
>YGL048C RPT6 SGDID:S000003016, Chr VII from 411286-410069, reverse complement, Verified ORF, "One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle"
>YGL049C TIF4632 SGDID:S000003017, Chr VII from 409604-406860, reverse complement, Verified ORF, "Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); homologous to Tif4631p"
>YGL050W TYW3 SGDID:S000003018, Chr VII from 405776-406597, Verified ORF, "tRNA methyltransferase required for synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions"
>YGL051W MST27 SGDID:S000003019, Chr VII from 403687-404391, Verified ORF, "Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles"
>YGL052W YGL052W SGDID:S000003020, Chr VII from 403437-403742, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MST27"
>YGL053W PRM8 SGDID:S000003021, Chr VII from 402589-403302, Verified ORF, "Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family"
>YGL054C ERV14 SGDID:S000003022, Chr VII from 401287-400871, reverse complement, Verified ORF, "Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon"
>YGL055W OLE1 SGDID:S000003023, Chr VII from 398628-400160, Verified ORF, "Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria"
>YGL056C SDS23 SGDID:S000003024, Chr VII from 397618-396035, reverse complement, Verified ORF, "One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding"
>YGL057C GEP7 SGDID:S000003025, Chr VII from 395829-394966, reverse complement, Verified ORF, "Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YGL058W RAD6 SGDID:S000003026, Chr VII from 393986-394504, Verified ORF, "Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (as a heterodimer with Rad18p), DSBR and checkpoint control (as a heterodimer with Bre1p), ubiquitin-mediated N-end rule protein degradation (as a heterodimer with Ubr1p"
>YGL059W PKP2 SGDID:S000003027, Chr VII from 392223-393698, Verified ORF, "Mitochondrial protein kinase that negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p"
>YGL060W YBP2 SGDID:S000003028, Chr VII from 390065-391990, Verified ORF, "Central kinetochore associated protein that mediates mitotic progression; interacts with several central kinetochore proteins and the centromeric histone Cse4p; role in resistance to oxidative stress; similarity to Ybp1p and Slk19p"
>YGL061C DUO1 SGDID:S000003029, Chr VII from 389711-388968, reverse complement, Verified ORF, "Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis"
>YGL062W PYC1 SGDID:S000003030, Chr VII from 385196-388732, Verified ORF, "Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis"
>YGL063C-A YGL063C-A SGDID:S000028633, Chr VII from 384651-384502, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YGL063W PUS2 SGDID:S000003031, Chr VII from 383654-384766, Verified ORF, "Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification"
>YGL064C MRH4 SGDID:S000003032, Chr VII from 383208-381523, reverse complement, Verified ORF, "Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function"
>YGL065C ALG2 SGDID:S000003033, Chr VII from 381271-379760, reverse complement, Verified ORF, "Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol"
>YGL066W SGF73 SGDID:S000003034, Chr VII from 377609-379582, Verified ORF, "SAGA complex subunit with a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases"
>YGL067W NPY1 SGDID:S000003035, Chr VII from 376101-377255, Verified ORF, "NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes"
>YGL068W MNP1 SGDID:S000003036, Chr VII from 375087-375671, Verified ORF, "Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth"
>YGL069C YGL069C SGDID:S000003037, Chr VII from 375514-375050, reverse complement, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance"
>YGL070C RPB9 SGDID:S000003038, Chr VII from 374827-374459, reverse complement, Verified ORF, "RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription"
>YGL071W AFT1 SGDID:S000003039, Chr VII from 372012-374084, Verified ORF, "Transcription factor involved in iron utilization and homeostasis; binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability"
>YGL072C YGL072C SGDID:S000003040, Chr VII from 371362-371003, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2"
>YGL073W HSF1 SGDID:S000003041, Chr VII from 368753-371254, Verified ORF, "Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated"
>YGL074C YGL074C SGDID:S000003042, Chr VII from 368922-368596, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor"
>YGL075C MPS2 SGDID:S000003043, Chr VII from 368088-366925, reverse complement, Verified ORF, "Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p"
>YGL076C RPL7A SGDID:S000003044, Chr VII from 364964-364335,365526-365433,365996-365986, reverse complement, Verified ORF, "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)"
>YGL077C HNM1 SGDID:S000003045, Chr VII from 363916-362225, reverse complement, Verified ORF, "Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol"
>YGL078C DBP3 SGDID:S000003046, Chr VII from 361859-360288, reverse complement, Verified ORF, "Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis"
>YGL079W KXD1 SGDID:S000003047, Chr VII from 359444-360100, Uncharacterized ORF, "Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome"
>YGL080W FMP37 SGDID:S000003048, Chr VII from 358636-359028, Uncharacterized ORF, "Putative protein of unknown function; highly conserved across species and orthologous to human gene BRP44L; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YGL081W YGL081W SGDID:S000003049, Chr VII from 357377-358339, Uncharacterized ORF, "Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis"
>YGL082W YGL082W SGDID:S000003050, Chr VII from 355827-356972, Uncharacterized ORF, "Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene"
>YGL083W SCY1 SGDID:S000003051, Chr VII from 353058-355472, Verified ORF, "Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase"
>YGL084C GUP1 SGDID:S000003052, Chr VII from 352298-350616, reverse complement, Verified ORF, "Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport"
>YGL085W LCL3 SGDID:S000003053, Chr VII from 349616-350440, Uncharacterized ORF, "Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS"
>YGL086W MAD1 SGDID:S000003054, Chr VII from 347119-349368, Verified ORF, "Coiled-coil protein involved in the spindle-assembly checkpoint; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p"
>YGL087C MMS2 SGDID:S000003055, Chr VII from 346808-346406,346904-346894, reverse complement, Verified ORF, "Ubiquitin-conjugating enzyme variant involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p"
>YGL088W YGL088W SGDID:S000003056, Chr VII from 345836-346201, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing"
>YGL089C MF(ALPHA)2 SGDID:S000003057, Chr VII from 345153-344791, reverse complement, Verified ORF, "Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2"
>YGL090W LIF1 SGDID:S000003058, Chr VII from 343319-344584, Verified ORF, "Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein"
>YGL091C NBP35 SGDID:S000003059, Chr VII from 343042-342056, reverse complement, Verified ORF, "Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases"
>YGL092W NUP145 SGDID:S000003060, Chr VII from 337906-341859, Verified ORF, "Essential nucleoporin, catalyzes its own cleavage in vivo to generate a C-terminal fragment that assembles into the Nup84p subcomplex of the nuclear pore complex, and an N-terminal fragment of unknown function that is homologous to Nup100p"
>YGL093W SPC105 SGDID:S000003061, Chr VII from 334886-337639, Verified ORF, "Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components"
>YGL094C PAN2 SGDID:S000003062, Chr VII from 334465-331118, reverse complement, Verified ORF, "Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes"
>YGL095C VPS45 SGDID:S000003063, Chr VII from 330607-328874, reverse complement, Verified ORF, "Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment"
>YGL096W TOS8 SGDID:S000003064, Chr VII from 325331-326161, Verified ORF, "Homeodomain-containing protein and putative transcription factor found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; similar to Cup9p transcription factor"
>YGL097W SRM1 SGDID:S000003065, Chr VII from 321782-323230, Verified ORF, "Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p"
>YGL098W USE1 SGDID:S000003066, Chr VII from 317342-318079, Verified ORF, "Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p"
>YGL099W LSG1 SGDID:S000003067, Chr VII from 314631-316553, Verified ORF, "Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm"
>YGL100W SEH1 SGDID:S000003068, Chr VII from 313234-314283, Verified ORF, "Nuclear pore protein that is part of the evolutionarily conserved Nup84p complex (Nup84p, Nup85p, Nup120p, Nup145p, and Seh1p); homologous to Sec13p"
>YGL101W YGL101W SGDID:S000003069, Chr VII from 312193-312840, Uncharacterized ORF, "Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p"
>YGL102C YGL102C SGDID:S000003070, Chr VII from 311933-311505, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein"
>YGL103W RPL28 SGDID:S000003071, Chr VII from 310967-311015,311527-311927, Verified ORF, "Ribosomal protein of the large (60S) ribosomal subunit, has similarity to E. coli L15 and rat L27a ribosomal proteins; may have peptidyl transferase activity; can mutate to cycloheximide resistance"
>YGL104C VPS73 SGDID:S000003072, Chr VII from 310173-308713, reverse complement, Verified ORF, "Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family"
>YGL105W ARC1 SGDID:S000003073, Chr VII from 307437-308567, Verified ORF, "Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids"
>YGL106W MLC1 SGDID:S000003074, Chr VII from 306560-307009, Verified ORF, "Essential light chain for Myo1p, light chain for Myo2p; stabilizes Myo2p by binding to the neck region; interacts with Myo1p, Iqg1p, and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition"
>YGL107C RMD9 SGDID:S000003075, Chr VII from 306273-304333, reverse complement, Verified ORF, "Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes"
>YGL108C YGL108C SGDID:S000003076, Chr VII from 304071-303649, reverse complement, Uncharacterized ORF, "Protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery"
>YGL109W YGL109W SGDID:S000003077, Chr VII from 303513-303836, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C"
>YGL110C CUE3 SGDID:S000003078, Chr VII from 303411-301537, reverse complement, Verified ORF, "Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination"
>YGL111W NSA1 SGDID:S000003079, Chr VII from 299978-301369, Verified ORF, "Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis"
>YGL112C TAF6 SGDID:S000003080, Chr VII from 299728-298178, reverse complement, Verified ORF, "Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4"
>YGL113W SLD3 SGDID:S000003081, Chr VII from 295932-297938, Verified ORF, "Protein involved in the initiation of DNA replication, required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p"
>YGL114W YGL114W SGDID:S000003082, Chr VII from 293460-295637, Uncharacterized ORF, "Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters"
>YGL115W SNF4 SGDID:S000003083, Chr VII from 292033-293001, Verified ORF, "Activating gamma subunit of the AMP-activated Snf1p kinase complex (contains Snf1p and a Sip1p/Sip2p/Gal83p family member); activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis"
>YGL116W CDC20 SGDID:S000003084, Chr VII from 289809-291641, Verified ORF, "Cell-cycle regulated activator of anaphase-promoting complex/cyclosome (APC/C), which is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; potential Cdc28p substrate"
>YGL117W YGL117W SGDID:S000003085, Chr VII from 288512-289309, Uncharacterized ORF, "Putative protein of unknown function"
>YGL118C YGL118C SGDID:S000003086, Chr VII from 288451-288014, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YGL119W COQ8 SGDID:S000003087, Chr VII from 284442-285947, Verified ORF, "Protein required for ubiquinone (coenzyme Q) biosynthesis and for respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis"
>YGL120C PRP43 SGDID:S000003088, Chr VII from 283937-281634, reverse complement, Verified ORF, "RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome"
>YGL121C GPG1 SGDID:S000003089, Chr VII from 281157-280777, reverse complement, Verified ORF, "Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; overproduction causes prion curing"
>YGL122C NAB2 SGDID:S000003090, Chr VII from 280523-278946, reverse complement, Verified ORF, "Nuclear polyadenylated RNA-binding protein required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p"
>YGL123C-A YGL123C-A SGDID:S000028634, Chr VII from 277864-277634, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene RPS2/YGL123W"
>YGL123W RPS2 SGDID:S000003091, Chr VII from 277617-278381, Verified ORF, "Protein component of the small (40S) subunit, essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p"
>YGL124C MON1 SGDID:S000003092, Chr VII from 276714-274780, reverse complement, Verified ORF, "Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate"
>YGL125W MET13 SGDID:S000003093, Chr VII from 272520-274322, Verified ORF, "Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway"
>YGL126W SCS3 SGDID:S000003094, Chr VII from 270997-272139, Verified ORF, "Protein required for inositol prototrophy, identified as an ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis; disputed role in the synthesis of inositol phospholipids from inositol"
>YGL127C SOH1 SGDID:S000003095, Chr VII from 270775-270392, reverse complement, Verified ORF, "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits"
>YGL128C CWC23 SGDID:S000003096, Chr VII from 270144-269293, reverse complement, Verified ORF, "Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p"
>YGL129C RSM23 SGDID:S000003097, Chr VII from 269075-267723, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p"
>YGL130W CEG1 SGDID:S000003098, Chr VII from 266145-267524, Verified ORF, "Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphosphatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide"
>YGL131C SNT2 SGDID:S000003099, Chr VII from 265859-261648, reverse complement, Verified ORF, "DNA binding protein with similarity to the S. pombe Snt2 protein; computational analysis suggests a role in regulation of expression of genes encoding amine transporters"
>YGL132W YGL132W SGDID:S000003100, Chr VII from 261580-261915, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SNT2/YGL131C"
>YGL133W ITC1 SGDID:S000003101, Chr VII from 257707-261501, Verified ORF, "Component of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1"
>YGL134W PCL10 SGDID:S000003102, Chr VII from 255663-256964, Verified ORF, "Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate"
>YGL135W RPL1B SGDID:S000003103, Chr VII from 254641-255294, Verified ORF, "N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Ap and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal"
>YGL136C MRM2 SGDID:S000003104, Chr VII from 253859-252897, reverse complement, Verified ORF, "Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ"
>YGL137W SEC27 SGDID:S000003105, Chr VII from 249869-249886,250087-252738, Verified ORF, "Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP"
>YGL138C YGL138C SGDID:S000003106, Chr VII from 249531-248494, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; has no significant sequence similarity to any known protein"
>YGL139W FLC3 SGDID:S000003107, Chr VII from 245716-248124, Verified ORF, "Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER"
>YGL140C YGL140C SGDID:S000003108, Chr VII from 245012-241353, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains"
>YGL141W HUL5 SGDID:S000003109, Chr VII from 238353-241085, Verified ORF, "Ubiquitin-conjugating enzyme (E4), elongates polyubiquitin chains on substrate proteins; works in opposition to Ubp6p polyubiquitin-shortening activity; required for retrograde transport of misfolded proteins into cytoplasm during ERAD"
>YGL142C GPI10 SGDID:S000003110, Chr VII from 238119-236269, reverse complement, Verified ORF, "Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog"
>YGL143C MRF1 SGDID:S000003111, Chr VII from 235958-234717, reverse complement, Verified ORF, "Mitochondrial translation release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability"
>YGL144C ROG1 SGDID:S000003112, Chr VII from 234507-232450, reverse complement, Verified ORF, "Protein with putative serine active lipase domain"
>YGL145W TIP20 SGDID:S000003113, Chr VII from 230243-232348, Verified ORF, "Peripheral membrane protein required for fusion of COPI vesicles with the ER; prohibits back-fusion of COPII vesicles with the ER; forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p"
>YGL146C RRT6 SGDID:S000003114, Chr VII from 229686-228751, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins"
>YGL147C RPL9A SGDID:S000003115, Chr VII from 228329-227754, reverse complement, Verified ORF, "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins"
>YGL148W ARO2 SGDID:S000003116, Chr VII from 226399-227529, Verified ORF, "Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids"
>YGL149W YGL149W SGDID:S000003117, Chr VII from 225572-225877, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C."
>YGL150C INO80 SGDID:S000003118, Chr VII from 225573-221104, reverse complement, Verified ORF, "ATPase, subunit of a complex containing actin and several actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; has a role in modulating stress gene transcription"
>YGL151W NUT1 SGDID:S000003119, Chr VII from 217524-220922, Verified ORF, "Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription"
>YGL152C YGL152C SGDID:S000003120, Chr VII from 217369-216692, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W"
>YGL153W PEX14 SGDID:S000003121, Chr VII from 216273-217298, Verified ORF, "Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p"
>YGL154C LYS5 SGDID:S000003122, Chr VII from 216096-215278, reverse complement, Verified ORF, "Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine"
>YGL155W CDC43 SGDID:S000003123, Chr VII from 214081-215211, Verified ORF, "Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis"
>YGL156W AMS1 SGDID:S000003124, Chr VII from 210416-213667, Verified ORF, "Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway"
>YGL157W ARI1 SGDID:S000003125, Chr VII from 209006-210049, Verified ORF, "NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily"
>YGL158W RCK1 SGDID:S000003126, Chr VII from 207033-208571, Verified ORF, "Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations"
>YGL159W YGL159W SGDID:S000003127, Chr VII from 202721-203833, Uncharacterized ORF, "Putative protein of unknown function; deletion mutant has no detectable phenotype"
>YGL160W AIM14 SGDID:S000003128, Chr VII from 200561-202273, Verified ORF, "Protein with similarity to iron/copper reductases (FRE1-8), possibly involved in iron homeostasis; may interact with ribosomes; null mutant displays elevated frequency of mitochondrial genome loss"
>YGL161C YIP5 SGDID:S000003129, Chr VII from 200142-199210, reverse complement, Verified ORF, "Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport"
>YGL162W SUT1 SGDID:S000003130, Chr VII from 198138-199037, Verified ORF, "Transcription factor of the Zn[II]2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression"
>YGL163C RAD54 SGDID:S000003131, Chr VII from 196403-193707, reverse complement, Verified ORF, "DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family"
>YGL164C YRB30 SGDID:S000003132, Chr VII from 193300-191978, reverse complement, Verified ORF, "RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes"
>YGL165C YGL165C SGDID:S000003133, Chr VII from 191976-191398, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W"
>YGL166W CUP2 SGDID:S000003134, Chr VII from 191129-191806, Verified ORF, "Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations"
>YGL167C PMR1 SGDID:S000003135, Chr VII from 190468-187616, reverse complement, Verified ORF, "High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease"
>YGL168W HUR1 SGDID:S000003136, Chr VII from 187464-187796, Verified ORF, "Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene"
>YGL169W SUA5 SGDID:S000003137, Chr VII from 186059-187339, Verified ORF, "Single-stranded telomeric DNA-binding protein, required for normal telomere length; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family"
>YGL170C SPO74 SGDID:S000003138, Chr VII from 185394-184153, reverse complement, Verified ORF, "Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation"
>YGL171W ROK1 SGDID:S000003139, Chr VII from 182390-184084, Verified ORF, "ATP-dependent RNA helicase of the DEAD box family; required for 18S rRNA synthesis"
>YGL172W NUP49 SGDID:S000003140, Chr VII from 180700-182118, Verified ORF, "Subunit of the Nsp1p-Nup57p-Nup49p-Nic96p subcomplex of the nuclear pore complex (NPC), required for nuclear export of ribosomes"
>YGL173C KEM1 SGDID:S000003141, Chr VII from 180113-175527, reverse complement, Verified ORF, "Evolutionarily-conserved 5'-3' exonuclease component of cytoplasmic processing (P) bodies involved in mRNA decay; plays a role in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, and telomere maintenance"
>YGL174W BUD13 SGDID:S000003142, Chr VII from 174545-175345, Verified ORF, "Subunit of the RES complex, which is required for nuclear pre-mRNA retention and splicing; involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern"
>YGL175C SAE2 SGDID:S000003143, Chr VII from 174322-173285, reverse complement, Verified ORF, "Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents"
>YGL176C YGL176C SGDID:S000003144, Chr VII from 173079-171415, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype"
>YGL177W YGL177W SGDID:S000003145, Chr VII from 167559-167906, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YGL178W MPT5 SGDID:S000003146, Chr VII from 167352-167354,167995-170571, Verified ORF, "Member of the Puf family of RNA-binding proteins; binds to mRNAs encoding chromatin modifiers and spindle pole body components; involved in longevity, maintenance of cell wall integrity, and sensitivity to and recovery from pheromone arrest"
>YGL179C TOS3 SGDID:S000003147, Chr VII from 165091-163409, reverse complement, Verified ORF, "Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome"
>YGL180W ATG1 SGDID:S000003148, Chr VII from 160065-162758, Verified ORF, "Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p"
>YGL181W GTS1 SGDID:S000003149, Chr VII from 157906-159096, Verified ORF, "Arf3p GTPase Activating Protein (GAP) that localizes to endocytic patches; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms; localizes to nucleus and induces flocculation when overexpressed"
>YGL182C YGL182C SGDID:S000003150, Chr VII from 157596-157273, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MND1/YGL183C"
>YGL183C MND1 SGDID:S000003151, Chr VII from 157199-156543,157285-157283, reverse complement, Verified ORF, "Protein required for recombination and meiotic nuclear division; forms a complex with Hop2p, which is involved in chromosome pairing and repair of meiotic double-strand breaks"
>YGL184C STR3 SGDID:S000003152, Chr VII from 156012-154615, reverse complement, Verified ORF, "Cystathionine beta-lyase, converts cystathionine into homocysteine"
>YGL185C YGL185C SGDID:S000003153, Chr VII from 154306-153167, reverse complement, Uncharacterized ORF, "Putative protein with sequence similarity to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"
>YGL186C TPN1 SGDID:S000003154, Chr VII from 152776-151037, reverse complement, Verified ORF, "Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p"
>YGL187C COX4 SGDID:S000003155, Chr VII from 150171-149704, reverse complement, Verified ORF, "Subunit IV of cytochrome c oxidase, the terminal member of the mitochondrial inner membrane electron transport chain; precursor N-terminal 25 residues are cleaved during mitochondrial import; phosphorylated; spermidine enhances translation"
>YGL188C YGL188C SGDID:S000003156, Chr VII from 149516-149343, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YGL188C-A YGL188C-A SGDID:S000028635, Chr VII from 148964-148824, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YGL189C RPS26A SGDID:S000003157, Chr VII from 148588-148229, reverse complement, Verified ORF, "Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Bp and has similarity to rat S26 ribosomal protein"
>YGL190C CDC55 SGDID:S000003158, Chr VII from 147389-145809, reverse complement, Verified ORF, "Non-essential regulatory subunit B of protein phosphatase 2A (PP2A), which has multiple roles in mitosis and protein biosynthesis; involved in regulation of mitotic exit; found in the nucleus of most cells, also at bud neck and bud tip"
>YGL191W COX13 SGDID:S000003159, Chr VII from 144808-145197, Verified ORF, "Subunit VIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP"
>YGL192W IME4 SGDID:S000003160, Chr VII from 142246-144048, Verified ORF, "Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids"
>YGL193C YGL193C SGDID:S000003161, Chr VII from 142227-141916, reverse complement, Uncharacterized ORF, "Haploid-specific gene repressed by a1-alpha2, turned off in sir3 null strains, absence enhances the sensitivity of rad52-327 cells to campothecin almost 100-fold"
>YGL194C HOS2 SGDID:S000003162, Chr VII from 141726-140368, reverse complement, Verified ORF, "Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity"
>YGL194C-A YGL194C-A SGDID:S000087160, Chr VII from 139961-139719, reverse complement, Uncharacterized ORF, "Putative protein of unknown function, identified based on comparisons of the genome sequences of six Saccharomyces species"
>YGL195W GCN1 SGDID:S000003163, Chr VII from 131525-139543, Verified ORF, "Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn20p; proposed to stimulate Gcn2p activation by an uncharged tRNA"
>YGL196W DSD1 SGDID:S000003164, Chr VII from 129883-131169, Verified ORF, "D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate"
>YGL197W MDS3 SGDID:S000003165, Chr VII from 124698-129161, Verified ORF, "Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain"
>YGL198W YIP4 SGDID:S000003166, Chr VII from 123591-124298, Verified ORF, "Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport"
>YGL199C YGL199C SGDID:S000003167, Chr VII from 124042-123572, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W"
>YGL200C EMP24 SGDID:S000003168, Chr VII from 123305-122694, reverse complement, Verified ORF, "Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport"
>YGL201C MCM6 SGDID:S000003169, Chr VII from 120907-117854, reverse complement, Verified ORF, "Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex"
>YGL202W ARO8 SGDID:S000003170, Chr VII from 116059-117561, Verified ORF, "Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis"
>YGL203C KEX1 SGDID:S000003171, Chr VII from 114664-112475, reverse complement, Verified ORF, "Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins"
>YGL204C YGL204C SGDID:S000003172, Chr VII from 112005-111700, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YGL205W POX1 SGDID:S000003173, Chr VII from 108158-110404, Verified ORF, "Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix"
>YGL206C CHC1 SGDID:S000003174, Chr VII from 107504-102543, reverse complement, Verified ORF, "Clathrin heavy chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; two heavy chains form the clathrin triskelion structural component; the light chain (CLC1) is thought to regulate function"
>YGL207W SPT16 SGDID:S000003175, Chr VII from 98969-102076, Verified ORF, "Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases"
>YGL208W SIP2 SGDID:S000003176, Chr VII from 97338-98585, Verified ORF, "One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane"
>YGL209W MIG2 SGDID:S000003177, Chr VII from 95858-97006, Verified ORF, "Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter"
>YGL210W YPT32 SGDID:S000003178, Chr VII from 93792-94460, Verified ORF, "Rab family GTPase, very similar to Ypt31p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi"
>YGL211W NCS6 SGDID:S000003179, Chr VII from 92512-93591, Verified ORF, "Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae"
>YGL212W VAM7 SGDID:S000003180, Chr VII from 91432-92382, Verified ORF, "Component of the vacuole SNARE complex involved in vacuolar morphogenesis; SNAP-25 homolog; functions with a syntaxin homolog Vam3p in vacuolar protein trafficking"
>YGL213C SKI8 SGDID:S000003181, Chr VII from 91247-90054, reverse complement, Verified ORF, "Ski complex component and WD-repeat protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype"
>YGL214W YGL214W SGDID:S000003182, Chr VII from 90010-90495, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion mutation phenotype is likely due to the overlapping verified ORF SKI8/YGL213C"
>YGL215W CLG1 SGDID:S000003183, Chr VII from 87981-89339, Verified ORF, "Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2"
>YGL216W KIP3 SGDID:S000003184, Chr VII from 84885-87302, Verified ORF, "Kinesin-related motor protein involved in mitotic spindle positioning"
>YGL217C YGL217C SGDID:S000003185, Chr VII from 85180-84839, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF KIP3/YGL216W"
>YGL218W YGL218W SGDID:S000003186, Chr VII from 83650-84300, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 93% of ORF overlaps the verified gene MDM34; deletion in cyr1 mutant results in loss of stress resistance"
>YGL219C MDM34 SGDID:S000003187, Chr VII from 84257-82878, reverse complement, Verified ORF, "Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth"
>YGL220W FRA2 SGDID:S000003188, Chr VII from 82374-82736, Verified ORF, "Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel"
>YGL221C NIF3 SGDID:S000003189, Chr VII from 82292-81426, reverse complement, Verified ORF, "Protein of unknown function, similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YGL222C EDC1 SGDID:S000003190, Chr VII from 81186-80659, reverse complement, Verified ORF, "RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress"
>YGL223C COG1 SGDID:S000003191, Chr VII from 80365-79112, reverse complement, Verified ORF, "Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments"
>YGL224C SDT1 SGDID:S000003192, Chr VII from 78857-78015, reverse complement, Verified ORF, "Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives"
>YGL225W VRG4 SGDID:S000003193, Chr VII from 76894-77907, Verified ORF, "Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi"
>YGL226C-A OST5 SGDID:S000003194, Chr VII from 72988-72749,73158-73138, reverse complement, Verified ORF, "Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins"
>YGL226W MTC3 SGDID:S000003195, Chr VII from 73340-73711, Verified ORF, "Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1"
>YGL227W VID30 SGDID:S000003196, Chr VII from 69671-72547, Verified ORF, "Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); binds FBPase; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm"
>YGL228W SHE10 SGDID:S000003197, Chr VII from 67598-69331, Verified ORF, "Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest"
>YGL229C SAP4 SGDID:S000003198, Chr VII from 66959-64503, reverse complement, Verified ORF, "Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p"
>YGL230C YGL230C SGDID:S000003199, Chr VII from 64215-63772, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; non-essential gene"
>YGL231C EMC4 SGDID:S000003200, Chr VII from 63620-63048, reverse complement, Verified ORF, "Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; human ortholog TMEM85 may function in apoptosis"
>YGL232W TAN1 SGDID:S000003201, Chr VII from 62075-62131,62190-63002, Verified ORF, "Putative tRNA acetyltransferase, RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA"
>YGL233W SEC15 SGDID:S000003202, Chr VII from 59122-61854, Verified ORF, "Essential 113kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which mediates polarized targeting of vesicles to active sites of exocytosis; Sec15p associates with Sec4p and vesicles"
>YGL234W ADE5,7 SGDID:S000003203, Chr VII from 56482-58890, Verified ORF, "Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities"
>YGL235W YGL235W SGDID:S000003204, Chr VII from 55279-55815, Uncharacterized ORF, "Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2"
>YGL236C MTO1 SGDID:S000003205, Chr VII from 55796-53787, reverse complement, Verified ORF, "Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants"
>YGL237C HAP2 SGDID:S000003206, Chr VII from 53528-52731, reverse complement, Verified ORF, "Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding"
>YGL238W CSE1 SGDID:S000003207, Chr VII from 49552-52434, Verified ORF, "Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation"
>YGL239C YGL239C SGDID:S000003208, Chr VII from 49745-49431, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene CSE1"
>YGL240W DOC1 SGDID:S000003209, Chr VII from 48613-49365, Verified ORF, "Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis"
>YGL241W KAP114 SGDID:S000003210, Chr VII from 45445-48459, Verified ORF, "Karyopherin, responsible for nuclear import of Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear"
>YGL242C YGL242C SGDID:S000003211, Chr VII from 45197-44652, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; deletion mutant is viable"
>YGL243W TAD1 SGDID:S000003212, Chr VII from 43307-44509, Verified ORF, "tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala"
>YGL244W RTF1 SGDID:S000003213, Chr VII from 41498-43174, Verified ORF, "Subunit of the RNA polymerase II-associated Paf1 complex; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in telomere maintenance"
>YGL245W GUS1 SGDID:S000003214, Chr VII from 39023-41149, Verified ORF, "Glutamyl-tRNA synthetase (GluRS), forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm"
>YGL246C RAI1 SGDID:S000003215, Chr VII from 38780-37617, reverse complement, Verified ORF, "Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z"
>YGL247W BRR6 SGDID:S000003216, Chr VII from 36933-37526, Verified ORF, "Essential nuclear envelope integral membrane protein required for nuclear envelope morphology, nuclear pore complex localization, nuclear export; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism"
>YGL248W PDE1 SGDID:S000003217, Chr VII from 35653-36762, Verified ORF, "Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation"
>YGL249W ZIP2 SGDID:S000003218, Chr VII from 33098-35212, Verified ORF, "Meiosis-specific protein involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis"
>YGL250W RMR1 SGDID:S000003219, Chr VII from 31910-32635, Verified ORF, "Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus"
>YGL251C HFM1 SGDID:S000003220, Chr VII from 31426-27921,31636-31579, reverse complement, Verified ORF, "Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity"
>YGL252C RTG2 SGDID:S000003221, Chr VII from 27484-25718, reverse complement, Verified ORF, "Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p"
>YGL253W HXK2 SGDID:S000003222, Chr VII from 23935-25395, Verified ORF, "Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene"
>YGL254W FZF1 SGDID:S000003223, Chr VII from 22304-23203, Verified ORF, "Transcription factor involved in sulfite metabolism, sole identified regulatory target is SSU1, overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers"
>YGL255W ZRT1 SGDID:S000003224, Chr VII from 20978-22108, Verified ORF, "High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor"
>YGL256W ADH4 SGDID:S000003225, Chr VII from 15159-16307, Verified ORF, "Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency"
>YGL257C MNT2 SGDID:S000003226, Chr VII from 14157-12481, reverse complement, Verified ORF, "Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans"
>YGL258W VEL1 SGDID:S000003227, Chr VII from 11110-11730, Verified ORF, "Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants"
>YGL258W-A YGL258W-A SGDID:S000007607, Chr VII from 9162-9395, Uncharacterized ORF, "Putative protein of unknown function"
>YGL259W YPS5 SGDID:S000003228, Chr VII from 8470-8967, Uncharacterized ORF, "Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p"
>YGL260W YGL260W SGDID:S000003229, Chr VII from 6860-7090, Uncharacterized ORF, "Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium"
>YGL261C PAU11 SGDID:S000003230, Chr VII from 6652-6290, reverse complement, Uncharacterized ORF, "Putative protein of unknown function and member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2"
>YGL262W YGL262W SGDID:S000003231, Chr VII from 5312-5839, Uncharacterized ORF, "Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene"
>YGL263W COS12 SGDID:S000003232, Chr VII from 2790-3932, Verified ORF, "Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins"
>YGR001C YGR001C SGDID:S000003233, Chr VII from 497365-497133,497937-497459,498034-498000, reverse complement, Uncharacterized ORF, "Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae"
>YGR002C SWC4 SGDID:S000003234, Chr VII from 499906-498476, reverse complement, Verified ORF, "Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex"
>YGR003W CUL3 SGDID:S000003235, Chr VII from 500132-502366, Verified ORF, "Ubiquitin-protein ligase, member of the cullin family with similarity to Cdc53p and human CUL3; required for ubiquitin-dependent degredation of the RNA Polymerase II subunit RPO21"
>YGR004W PEX31 SGDID:S000003236, Chr VII from 502938-504326, Verified ORF, "Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p"
>YGR005C TFG2 SGDID:S000003237, Chr VII from 505859-504657, reverse complement, Verified ORF, "TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30"
>YGR006W PRP18 SGDID:S000003238, Chr VII from 506070-506825, Verified ORF, "Splicing factor involved in the positioning of the 3' splice site during the second catalytic step of splicing, part of snRNP U5, interacts with Slu7p"
>YGR007W ECT1 SGDID:S000003239, Chr VII from 506969-507940, Verified ORF, "Ethanolamine-phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases"
>YGR008C STF2 SGDID:S000003240, Chr VII from 508364-508110, reverse complement, Verified ORF, "Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein"
>YGR009C SEC9 SGDID:S000003241, Chr VII from 511002-509047, reverse complement, Verified ORF, "t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog"
>YGR010W NMA2 SGDID:S000003242, Chr VII from 511545-512732, Verified ORF, "Nicotinic acid mononucleotide adenylyltransferase, involved in de novo and salvage synthesis of NAD(+)"
>YGR011W YGR011W SGDID:S000003243, Chr VII from 512497-512823, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YGR012W YGR012W SGDID:S000003244, Chr VII from 513159-514340, Verified ORF, "Putative cysteine synthase, localized to the mitochondrial outer membrane"
>YGR013W SNU71 SGDID:S000003245, Chr VII from 514554-516416, Verified ORF, "Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart"
>YGR014W MSB2 SGDID:S000003246, Chr VII from 516943-520863, Verified ORF, "Mucin family member involved in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate"
>YGR015C YGR015C SGDID:S000003247, Chr VII from 522076-521090, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion"
>YGR016W YGR016W SGDID:S000003248, Chr VII from 522261-522833, Uncharacterized ORF, "Putative protein of unknown function"
>YGR017W YGR017W SGDID:S000003249, Chr VII from 523787-524680, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm"
>YGR018C YGR018C SGDID:S000003250, Chr VII from 524694-524365, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YGR017W"
>YGR019W UGA1 SGDID:S000003251, Chr VII from 525229-526644, Verified ORF, "Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization"
>YGR020C VMA7 SGDID:S000003252, Chr VII from 527329-526973, reverse complement, Verified ORF, "Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane"
>YGR021W YGR021W SGDID:S000003253, Chr VII from 527632-528504, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YGR022C YGR022C SGDID:S000003254, Chr VII from 529586-529257, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W"
>YGR023W MTL1 SGDID:S000003255, Chr VII from 529264-530919, Verified ORF, "Putative plasma membrane sensor, involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p"
>YGR024C THG1 SGDID:S000003256, Chr VII from 532596-531883, reverse complement, Verified ORF, "tRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes"
>YGR025W YGR025W SGDID:S000003257, Chr VII from 532639-532941, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YGR026W YGR026W SGDID:S000003258, Chr VII from 532985-533821, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery"
>YGR027C RPS25A SGDID:S000003259, Chr VII from 534458-534132, reverse complement, Verified ORF, "Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Bp and has similarity to rat S25 ribosomal protein"
>YGR027W-A YGR027W-A SGDID:S000007405, Chr VII from 536057-537379, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YGR027W-B YGR027W-B SGDID:S000007406, Chr VII from 536057-537361,537363-541325, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YGR028W MSP1 SGDID:S000003260, Chr VII from 542203-543291, Verified ORF, "Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase"
>YGR029W ERV1 SGDID:S000003261, Chr VII from 543553-543638,543722-544205, Verified ORF, "Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR)"
>YGR030C POP6 SGDID:S000003262, Chr VII from 546157-545681, reverse complement, Verified ORF, "Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends"
>YGR031C-A NAG1 SGDID:S000028636, Chr VII from 547300-546809, reverse complement, Verified ORF, "Protein involved in yeast cell wall biogenesis; localizes to the cell periphery; production of Nag1p is dependent upon the presence of Slt2p and Rlm1p; null is hypersensitive to calcofluor white; overlaps the uncharacterized ORF YGR031W"
>YGR031W YGR031W SGDID:S000003263, Chr VII from 546441-547469, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YGR032W GSC2 SGDID:S000003264, Chr VII from 548264-553951, Verified ORF, "Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)"
>YGR033C TIM21 SGDID:S000003265, Chr VII from 554967-554248, reverse complement, Verified ORF, "Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate TIM23 complex activity"
>YGR034W RPL26B SGDID:S000003266, Chr VII from 555812-555830,556308-556672, Verified ORF, "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Ap and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA"
>YGR035C YGR035C SGDID:S000003267, Chr VII from 557422-557072, reverse complement, Uncharacterized ORF, "Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance"
>YGR035W-A YGR035W-A SGDID:S000028827, Chr VII from 557565-557786, Uncharacterized ORF, "Putative protein of unknown function"
>YGR036C CAX4 SGDID:S000003268, Chr VII from 558868-558149, reverse complement, Verified ORF, "Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation"
>YGR037C ACB1 SGDID:S000003269, Chr VII from 559994-559731, reverse complement, Verified ORF, "Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion"
>YGR038C-A YGR038C-A SGDID:S000007407, Chr VII from 567467-566145, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YGR038C-B YGR038C-B SGDID:S000007408, Chr VII from 566161-562199,567467-566163, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YGR038W ORM1 SGDID:S000003270, Chr VII from 560682-561350, Verified ORF, "Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control"
>YGR039W YGR039W SGDID:S000003271, Chr VII from 574888-575199, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722"
>YGR040W KSS1 SGDID:S000003272, Chr VII from 575398-576504, Verified ORF, "Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains"
>YGR041W BUD9 SGDID:S000003273, Chr VII from 577487-579130, Verified ORF, "Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole"
>YGR042W YGR042W SGDID:S000003274, Chr VII from 579476-580291, Uncharacterized ORF, "Putative protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus"
>YGR043C NQM1 SGDID:S000003275, Chr VII from 581436-580435, reverse complement, Verified ORF, "Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift"
>YGR044C RME1 SGDID:S000003276, Chr VII from 583892-582990, reverse complement, Verified ORF, "Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation"
>YGR045C YGR045C SGDID:S000003277, Chr VII from 584296-583934, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YGR046W TAM41 SGDID:S000003278, Chr VII from 584895-586052, Verified ORF, "Mitochondrial protein involved in protein import into the mitochondrial matrix; maintains the functional integrity of the TIM23 protein translocator complex; viability of null mutant is strain-dependent; mRNA is targeted to the bud"
>YGR047C TFC4 SGDID:S000003279, Chr VII from 589469-586392, reverse complement, Verified ORF, "One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102"
>YGR048W UFD1 SGDID:S000003280, Chr VII from 589826-590911, Verified ORF, "Protein that interacts with Cdc48p and Npl4p, involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation; involved in transporting proteins from the ER to the cytosol"
>YGR049W SCM4 SGDID:S000003281, Chr VII from 591314-591877, Verified ORF, "Potential regulatory effector of CDC4 function, suppresses a temperature-sensitive allele of CDC4, tripartite protein structure in which a charged region separates two uncharged domains, not essential for mitosis or meiosis"
>YGR050C YGR050C SGDID:S000003282, Chr VII from 592442-592086, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YGR051C YGR051C SGDID:S000003283, Chr VII from 593229-592906, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene"
>YGR052W FMP48 SGDID:S000003284, Chr VII from 593596-594705, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation"
>YGR053C YGR053C SGDID:S000003285, Chr VII from 595837-594986, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YGR054W YGR054W SGDID:S000003286, Chr VII from 596693-598621, Verified ORF, "Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A"
>YGR055W MUP1 SGDID:S000003287, Chr VII from 599417-601141, Verified ORF, "High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake"
>YGR056W RSC1 SGDID:S000003288, Chr VII from 601661-604447, Verified ORF, "Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook"
>YGR057C LST7 SGDID:S000003289, Chr VII from 605501-604773, reverse complement, Verified ORF, "Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface"
>YGR058W PEF1 SGDID:S000003290, Chr VII from 606136-607143, Verified ORF, "Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2"
>YGR059W SPR3 SGDID:S000003291, Chr VII from 607563-609101, Verified ORF, "Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI"
>YGR060W ERG25 SGDID:S000003292, Chr VII from 610564-611493, Verified ORF, "C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol"
>YGR061C ADE6 SGDID:S000003293, Chr VII from 615965-611889, reverse complement, Verified ORF, "Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway"
>YGR062C COX18 SGDID:S000003294, Chr VII from 617278-616328, reverse complement, Verified ORF, "Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC"
>YGR063C SPT4 SGDID:S000003295, Chr VII from 617824-617516, reverse complement, Verified ORF, "Protein involved in the regulating Pol I and Pol II transcription, pre-mRNA processing, kinetochore function, and gene silencing; forms a complex with Spt5p"
>YGR064W YGR064W SGDID:S000003296, Chr VII from 617621-617989, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C"
>YGR065C VHT1 SGDID:S000003297, Chr VII from 619858-618077, reverse complement, Verified ORF, "High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin"
>YGR066C YGR066C SGDID:S000003298, Chr VII from 621799-620921, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YGR067C YGR067C SGDID:S000003299, Chr VII from 624786-622372, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p"
>YGR068C ART5 SGDID:S000003300, Chr VII from 627084-625324, reverse complement, Verified ORF, "Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane"
>YGR068W-A YGR068W-A SGDID:S000028637, Chr VII from 626294-626389, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with the uncharacterized ORF YGR068C"
>YGR069W YGR069W SGDID:S000003301, Chr VII from 627083-627418, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YGR070W ROM1 SGDID:S000003302, Chr VII from 627806-631273, Verified ORF, "GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP"
>YGR071C YGR071C SGDID:S000003303, Chr VII from 634063-631481, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus"
>YGR072W UPF3 SGDID:S000003304, Chr VII from 634304-635467, Verified ORF, "Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance"
>YGR073C YGR073C SGDID:S000003305, Chr VII from 635986-635615, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, extensively overlaps essential SMD1 gene encoding a U6 snRNP protein"
>YGR074W SMD1 SGDID:S000003306, Chr VII from 635712-636152, Verified ORF, "Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D1"
>YGR075C PRP38 SGDID:S000003307, Chr VII from 636875-636147, reverse complement, Verified ORF, "Unique component of the U4/U6.U5 tri-snRNP particle, required for conformational changes which result in the catalytic activation of the spliceosome; dispensible for spliceosome assembly"
>YGR076C MRPL25 SGDID:S000003308, Chr VII from 637577-637104, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the large subunit"
>YGR077C PEX8 SGDID:S000003309, Chr VII from 639513-637744, reverse complement, Verified ORF, "Intraperoxisomal organizer of the peroxisomal import machinery, tightly associated with the lumenal face of the peroxisomal membrane, essential for peroxisome biogenesis, binds PTS1-signal receptor Pex5p"
>YGR078C PAC10 SGDID:S000003310, Chr VII from 640371-639772, reverse complement, Verified ORF, "Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding"
>YGR079W YGR079W SGDID:S000003311, Chr VII from 640720-641832, Uncharacterized ORF, "Putative protein of unknown function; YGR079W is not an essential gene"
>YGR080W TWF1 SGDID:S000003312, Chr VII from 642010-643008, Verified ORF, "Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly"
>YGR081C SLX9 SGDID:S000003313, Chr VII from 643780-643148, reverse complement, Verified ORF, "Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant"
>YGR082W TOM20 SGDID:S000003314, Chr VII from 644044-644595, Verified ORF, "Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins"
>YGR083C GCD2 SGDID:S000003315, Chr VII from 646815-644860, reverse complement, Verified ORF, "Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression"
>YGR084C MRP13 SGDID:S000003316, Chr VII from 648142-647123, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the small subunit"
>YGR085C RPL11B SGDID:S000003317, Chr VII from 648907-648383, reverse complement, Verified ORF, "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11"
>YGR086C PIL1 SGDID:S000003318, Chr VII from 650617-649598, reverse complement, Verified ORF, "Primary component of eisosomes, which are large immobile cell cortex structures associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria"
>YGR087C PDC6 SGDID:S000003319, Chr VII from 652981-651290, reverse complement, Verified ORF, "Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation"
>YGR088W CTT1 SGDID:S000003320, Chr VII from 654634-656322, Verified ORF, "Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide"
>YGR089W NNF2 SGDID:S000003321, Chr VII from 656960-659770, Verified ORF, "Protein that exhibits physical and genetic interactions with Rpb8p, which is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation"
>YGR090W UTP22 SGDID:S000003322, Chr VII from 662358-666071, Verified ORF, "Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data"
>YGR091W PRP31 SGDID:S000003323, Chr VII from 666341-667825, Verified ORF, "Splicing factor, component of the U4/U6-U5 snRNP complex"
>YGR092W DBF2 SGDID:S000003324, Chr VII from 668189-669907, Verified ORF, "Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis"
>YGR093W YGR093W SGDID:S000003325, Chr VII from 670388-671911, Uncharacterized ORF, "Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus"
>YGR094W VAS1 SGDID:S000003326, Chr VII from 672186-675500, Verified ORF, "Mitochondrial and cytoplasmic valyl-tRNA synthetase"
>YGR095C RRP46 SGDID:S000003327, Chr VII from 676342-675671, reverse complement, Verified ORF, "Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)"
>YGR096W TPC1 SGDID:S000003328, Chr VII from 676621-677565, Verified ORF, "Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family"
>YGR097W ASK10 SGDID:S000003329, Chr VII from 678695-682135, Verified ORF, "Component of RNA polymerase II holoenzyme, phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; paralogous to Rgc1p"
>YGR098C ESP1 SGDID:S000003330, Chr VII from 687458-682566, reverse complement, Verified ORF, "Separase, a caspase-like cysteine protease that promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p"
>YGR099W TEL2 SGDID:S000003331, Chr VII from 687899-689965, Verified ORF, "Essential DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect"
>YGR100W MDR1 SGDID:S000003332, Chr VII from 690245-693097, Verified ORF, "Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function"
>YGR101W PCP1 SGDID:S000003333, Chr VII from 693363-694403, Verified ORF, "Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases"
>YGR102C YGR102C SGDID:S000003334, Chr VII from 695135-694584, reverse complement, Verified ORF, "Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria"
>YGR103W NOP7 SGDID:S000003335, Chr VII from 695417-697234, Verified ORF, "Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G<sub>0</sub> and the initiation of cell proliferation"
>YGR104C SRB5 SGDID:S000003336, Chr VII from 698368-697445, reverse complement, Verified ORF, "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in telomere maintenance"
>YGR105W VMA21 SGDID:S000003337, Chr VII from 698599-698832, Verified ORF, "Integral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)"
>YGR106C VOA1 SGDID:S000003338, Chr VII from 699786-698989, reverse complement, Verified ORF, "Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval"
>YGR107W YGR107W SGDID:S000003339, Chr VII from 702667-703116, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YGR108W CLB1 SGDID:S000003340, Chr VII from 703636-705051, Verified ORF, "B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome"
>YGR109C CLB6 SGDID:S000003341, Chr VII from 706501-705359, reverse complement, Verified ORF, "B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1"
>YGR109W-A YGR109W-A SGDID:S000007346, Chr VII from 707610-708482, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YGR109W-B YGR109W-B SGDID:S000007347, Chr VII from 707610-708459,708461-712254, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YGR110W CLD1 SGDID:S000003342, Chr VII from 713709-715046, Verified ORF, "Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58"
>YGR111W YGR111W SGDID:S000003343, Chr VII from 715828-717030, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus"
>YGR112W SHY1 SGDID:S000003344, Chr VII from 717358-718527, Verified ORF, "Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome"
>YGR113W DAM1 SGDID:S000003345, Chr VII from 718893-719924, Verified ORF, "Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments"
>YGR114C YGR114C SGDID:S000003346, Chr VII from 720654-720265, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6"
>YGR115C YGR115C SGDID:S000003347, Chr VII from 721151-720372, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C"
>YGR116W SPT6 SGDID:S000003348, Chr VII from 720409-724764, Verified ORF, "Transcription elongation factor required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region"
>YGR117C YGR117C SGDID:S000003349, Chr VII from 726479-725049, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"
>YGR118W RPS23A SGDID:S000003350, Chr VII from 726974-727038,727358-727730, Verified ORF, "Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Bp and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal"
>YGR119C NUP57 SGDID:S000003351, Chr VII from 729671-728046, reverse complement, Verified ORF, "Nucleoporin, essential subunit of the nuclear pore complex (NPC), functions as the organizing center of an NPC subcomplex containing Nsp1p, Nup49p, Nup57p, and Nic96p"
>YGR120C COG2 SGDID:S000003352, Chr VII from 730821-730033, reverse complement, Verified ORF, "Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments"
>YGR121C MEP1 SGDID:S000003353, Chr VII from 732927-731449, reverse complement, Verified ORF, "Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation"
>YGR121W-A YGR121W-A SGDID:S000028550, Chr VII from 733412-733627, Uncharacterized ORF, "Putative protein of unknown function"
>YGR122C-A YGR122C-A SGDID:S000007240, Chr VII from 735758-735630, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W"
>YGR122W YGR122W SGDID:S000003354, Chr VII from 733935-735143, Verified ORF, "Probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic"
>YGR123C PPT1 SGDID:S000003355, Chr VII from 738203-736662, reverse complement, Verified ORF, "Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth; computational analyses suggest roles in phosphate metabolism and rRNA processing"
>YGR124W ASN2 SGDID:S000003356, Chr VII from 739944-741662, Verified ORF, "Asparagine synthetase, isozyme of Asn1p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway"
>YGR125W YGR125W SGDID:S000003357, Chr VII from 742325-745435, Uncharacterized ORF, "Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole"
>YGR126W YGR126W SGDID:S000003358, Chr VII from 745835-746527, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS"
>YGR127W YGR127W SGDID:S000003359, Chr VII from 746798-747736, Uncharacterized ORF, "Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response"
>YGR128C UTP8 SGDID:S000003360, Chr VII from 750091-747950, reverse complement, Verified ORF, "Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA"
>YGR129W SYF2 SGDID:S000003361, Chr VII from 750400-751047, Verified ORF, "Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; isy1 syf2 cells have defective spindles activiating cell cycle arrest"
>YGR130C YGR130C SGDID:S000003362, Chr VII from 753844-751394, reverse complement, Verified ORF, "Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; possible component of the eisosome; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)"
>YGR131W FHN1 SGDID:S000003363, Chr VII from 754726-755250, Verified ORF, "Protein of unknown function; induced by ketoconazole; promoter region contains sterol regulatory element motif, which has been identified as a Upc2p-binding site; overexpression complements function of Nce102p in NCE102 deletion strain"
>YGR132C PHB1 SGDID:S000003364, Chr VII from 756452-755589, reverse complement, Verified ORF, "Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation"
>YGR133W PEX4 SGDID:S000003365, Chr VII from 756896-757447, Verified ORF, "Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis"
>YGR134W CAF130 SGDID:S000003366, Chr VII from 757770-761138, Verified ORF, "Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation"
>YGR135W PRE9 SGDID:S000003367, Chr VII from 761392-762168, Verified ORF, "Alpha 3 subunit of the 20S proteasome, the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform"
>YGR136W LSB1 SGDID:S000003368, Chr VII from 762428-763153, Verified ORF, "Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization"
>YGR137W YGR137W SGDID:S000003369, Chr VII from 762888-763262, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YGR138C TPO2 SGDID:S000003370, Chr VII from 765606-763762, reverse complement, Verified ORF, "Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily"
>YGR139W YGR139W SGDID:S000003371, Chr VII from 765726-766064, Dubious ORF, "Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YGR140W CBF2 SGDID:S000003372, Chr VII from 767429-770299, Verified ORF, "Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo"
>YGR141W VPS62 SGDID:S000003373, Chr VII from 770569-771972, Verified ORF, "Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins"
>YGR142W BTN2 SGDID:S000003374, Chr VII from 772454-773686, Verified ORF, "v-SNARE binding protein that facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase"
>YGR143W SKN1 SGDID:S000003375, Chr VII from 775193-777508, Verified ORF, "Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p"
>YGR144W THI4 SGDID:S000003376, Chr VII from 780399-781379, Verified ORF, "Thiazole synthase, catalyzes formation of a thiazole intermediate during thiamine biosynthesis; required for mitochondrial genome stability in response to DNA damaging agents"
>YGR145W ENP2 SGDID:S000003377, Chr VII from 781767-783890, Verified ORF, "Essential nucleolar protein, required for biogenesis of the small ribosomal subunit; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p"
>YGR146C ECL1 SGDID:S000003378, Chr VII from 784858-784223, reverse complement, Verified ORF, "Protein of unknown function, affects chronological lifespan; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation"
>YGR146C-A YGR146C-A SGDID:S000028638, Chr VII from 785437-785276, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YGR147C NAT2 SGDID:S000003379, Chr VII from 786920-786054, reverse complement, Verified ORF, "Protein with an apparent role in acetylation of N-terminal methionine residues"
>YGR148C RPL24B SGDID:S000003380, Chr VII from 787779-787312, reverse complement, Verified ORF, "Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate"
>YGR149W YGR149W SGDID:S000003381, Chr VII from 789031-790329, Uncharacterized ORF, "Putative protein of unknown function; predicted to be an integal membrane protein"
>YGR150C CCM1 SGDID:S000003382, Chr VII from 793053-790459, reverse complement, Verified ORF, "Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport"
>YGR151C YGR151C SGDID:S000003383, Chr VII from 794990-794655, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C"
>YGR152C RSR1 SGDID:S000003384, Chr VII from 795492-794674, reverse complement, Verified ORF, "GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases"
>YGR153W YGR153W SGDID:S000003385, Chr VII from 796092-796745, Uncharacterized ORF, "Putative protein of unknown function"
>YGR154C GTO1 SGDID:S000003386, Chr VII from 797868-796798, reverse complement, Verified ORF, "Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization"
>YGR155W CYS4 SGDID:S000003387, Chr VII from 798543-800066, Verified ORF, "Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; mutations in human ortholog cause homocystinuria"
>YGR156W PTI1 SGDID:S000003388, Chr VII from 800546-801823, Verified ORF, "Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64"
>YGR157W CHO2 SGDID:S000003389, Chr VII from 802440-805049, Verified ORF, "Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis"
>YGR158C MTR3 SGDID:S000003390, Chr VII from 806021-805269, reverse complement, Verified ORF, "Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)"
>YGR159C NSR1 SGDID:S000003391, Chr VII from 807656-806412, reverse complement, Verified ORF, "Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis"
>YGR160W YGR160W SGDID:S000003392, Chr VII from 807073-807684, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YGR161C RTS3 SGDID:S000003393, Chr VII from 809420-808629, reverse complement, Uncharacterized ORF, "Putative component of the protein phosphatase type 2A complex"
>YGR161C-C YGR161C-C SGDID:S000007367, Chr VII from 823015-821693, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YGR161C-D YGR161C-D SGDID:S000007368, Chr VII from 821709-817747,823015-821711, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YGR161W-A YGR161W-A SGDID:S000007369, Chr VII from 811738-813054, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YGR161W-B YGR161W-B SGDID:S000007370, Chr VII from 811738-813030,813032-817051, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YGR161W-C YGR161W-C SGDID:S000029726, Chr VII from 810227-810505, Uncharacterized ORF, "Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species"
>YGR162W TIF4631 SGDID:S000003394, Chr VII from 824059-826917, Verified ORF, "Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit"
>YGR163W GTR2 SGDID:S000003395, Chr VII from 827552-828577, Verified ORF, "Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD"
>YGR164W YGR164W SGDID:S000003396, Chr VII from 828625-828960, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YGR165W MRPS35 SGDID:S000003397, Chr VII from 829116-830153, Verified ORF, "Mitochondrial ribosomal protein of the small subunit"
>YGR166W KRE11 SGDID:S000003398, Chr VII from 830515-832197, Verified ORF, "Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response"
>YGR167W CLC1 SGDID:S000003399, Chr VII from 832456-833157, Verified ORF, "Clathrin light chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component"
>YGR168C YGR168C SGDID:S000003400, Chr VII from 834482-833352, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; YGR168C is not an essential gene"
>YGR169C PUS6 SGDID:S000003401, Chr VII from 835903-834689, reverse complement, Verified ORF, "tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability"
>YGR169C-A YGR169C-A SGDID:S000028521, Chr VII from 836665-836387, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YGR170W PSD2 SGDID:S000003402, Chr VII from 837142-840558, Verified ORF, "Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine"
>YGR171C MSM1 SGDID:S000003403, Chr VII from 842551-840824, reverse complement, Verified ORF, "Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p"
>YGR172C YIP1 SGDID:S000003404, Chr VII from 843591-842845, reverse complement, Verified ORF, "Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles"
>YGR173W RBG2 SGDID:S000003405, Chr VII from 843854-844960, Verified ORF, "Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein"
>YGR174C CBP4 SGDID:S000003406, Chr VII from 846405-845893, reverse complement, Verified ORF, "Mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex); interacts with Cbp3p and function is partially redundant with that of Cbp3p"
>YGR174W-A YGR174W-A SGDID:S000028639, Chr VII from 846655-846741, Uncharacterized ORF, "Putative protein of unknown function; predicted to have a role in cell budding based on computational "guilt by association" analysis"
>YGR175C ERG1 SGDID:S000003407, Chr VII from 848423-846933, reverse complement, Verified ORF, "Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine"
>YGR176W YGR176W SGDID:S000003408, Chr VII from 848720-849067, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YGR177C ATF2 SGDID:S000003409, Chr VII from 850436-848829, reverse complement, Verified ORF, "Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking"
>YGR178C PBP1 SGDID:S000003410, Chr VII from 853215-851047, reverse complement, Verified ORF, "Component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation"
>YGR179C OKP1 SGDID:S000003411, Chr VII from 854895-853675, reverse complement, Verified ORF, "Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly"
>YGR180C RNR4 SGDID:S000003412, Chr VII from 856301-855264, reverse complement, Verified ORF, "Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits"
>YGR181W TIM13 SGDID:S000003413, Chr VII from 858287-858604, Verified ORF, "Mitochondrial intermembrane space protein, forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane"
>YGR182C YGR182C SGDID:S000003414, Chr VII from 858904-858551, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W"
>YGR183C QCR9 SGDID:S000003415, Chr VII from 859260-859063,859476-859474, reverse complement, Verified ORF, "Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex"
>YGR184C UBR1 SGDID:S000003416, Chr VII from 865753-859901, reverse complement, Verified ORF, "E3 ubiquitin ligase (N-recognin), forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)"
>YGR185C TYS1 SGDID:S000003417, Chr VII from 867520-866336, reverse complement, Verified ORF, "Cytoplasmic tyrosyl-tRNA synthetase, required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies"
>YGR186W TFG1 SGDID:S000003418, Chr VII from 867774-869981, Verified ORF, "TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74"
>YGR187C HGH1 SGDID:S000003419, Chr VII from 871416-870232, reverse complement, Verified ORF, "Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16)"
>YGR188C BUB1 SGDID:S000003420, Chr VII from 875109-872044, reverse complement, Verified ORF, "Protein kinase that forms a complex with Mad1p and Bub3p that is crucial in the checkpoint mechanism required to prevent cell cycle progression into anaphase in the presence of spindle damage, associates with centromere DNA via Skp1p"
>YGR189C CRH1 SGDID:S000003421, Chr VII from 878192-876669, reverse complement, Verified ORF, "Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress"
>YGR190C YGR190C SGDID:S000003422, Chr VII from 880661-880296, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W"
>YGR191W HIP1 SGDID:S000003423, Chr VII from 880420-882231, Verified ORF, "High-affinity histidine permease, also involved in the transport of manganese ions"
>YGR192C TDH3 SGDID:S000003424, Chr VII from 883810-882812, reverse complement, Verified ORF, "Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall"
>YGR193C PDX1 SGDID:S000003425, Chr VII from 885741-884509, reverse complement, Verified ORF, "Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core"
>YGR194C XKS1 SGDID:S000003426, Chr VII from 887875-886073, reverse complement, Verified ORF, "Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains"
>YGR195W SKI6 SGDID:S000003427, Chr VII from 888882-889622, Verified ORF, "Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)"
>YGR196C FYV8 SGDID:S000003428, Chr VII from 892186-889733, reverse complement, Verified ORF, "Protein of unknown function, required for survival upon exposure to K1 killer toxin"
>YGR197C SNG1 SGDID:S000003429, Chr VII from 894140-892497, reverse complement, Verified ORF, "Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance"
>YGR198W YPP1 SGDID:S000003430, Chr VII from 894693-897146, Verified ORF, "Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene"
>YGR199W PMT6 SGDID:S000003431, Chr VII from 897502-899781, Verified ORF, "Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases"
>YGR200C ELP2 SGDID:S000003432, Chr VII from 902270-899904, reverse complement, Verified ORF, "Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin"
>YGR201C YGR201C SGDID:S000003433, Chr VII from 903197-902520, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YGR202C PCT1 SGDID:S000003434, Chr VII from 904748-903474, reverse complement, Verified ORF, "Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase, rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding"
>YGR203W YCH1 SGDID:S000003435, Chr VII from 905237-905683, Verified ORF, "Phosphatase with sequence similarity to Cdc25p, Arr2p and Mih1p; member of the single-domain rhodanese homology superfamily; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus"
>YGR204C-A YGR204C-A SGDID:S000028640, Chr VII from 909174-909061, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YGR204W ADE3 SGDID:S000003436, Chr VII from 905934-908774, Verified ORF, "Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine"
>YGR205W YGR205W SGDID:S000003437, Chr VII from 909213-910085, Verified ORF, "ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases"
>YGR206W MVB12 SGDID:S000003438, Chr VII from 910432-910737, Verified ORF, "ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin"
>YGR207C YGR207C SGDID:S000003439, Chr VII from 911628-910843, reverse complement, Verified ORF, "Protein that interacts with frataxin (Yfh1p); putative homolog of mammalian electron transfer flavoprotein complex subunit ETF-beta; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YGR208W SER2 SGDID:S000003440, Chr VII from 911883-912812, Verified ORF, "Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source"
>YGR209C TRX2 SGDID:S000003441, Chr VII from 913227-912913, reverse complement, Verified ORF, "Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance"
>YGR210C YGR210C SGDID:S000003442, Chr VII from 914738-913503, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"
>YGR211W ZPR1 SGDID:S000003443, Chr VII from 915241-916701, Verified ORF, "Essential protein with two zinc fingers, present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p)"
>YGR212W SLI1 SGDID:S000003444, Chr VII from 917040-918446, Verified ORF, "N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin"
>YGR213C RTA1 SGDID:S000003445, Chr VII from 919465-918512, reverse complement, Verified ORF, "Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein"
>YGR214W RPS0A SGDID:S000003446, Chr VII from 920575-920664,921120-921788, Verified ORF, "Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal"
>YGR215W RSM27 SGDID:S000003447, Chr VII from 922175-922507, Verified ORF, "Mitochondrial ribosomal protein of the small subunit"
>YGR216C GPI1 SGDID:S000003448, Chr VII from 924462-922633, reverse complement, Verified ORF, "Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs"
>YGR217W CCH1 SGDID:S000003449, Chr VII from 924696-930815, Verified ORF, "Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together"
>YGR218W CRM1 SGDID:S000003450, Chr VII from 932541-935795, Verified ORF, "Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin"
>YGR219W YGR219W SGDID:S000003451, Chr VII from 936035-936376, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C"
>YGR220C MRPL9 SGDID:S000003452, Chr VII from 936883-936074, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the large subunit"
>YGR221C TOS2 SGDID:S000003453, Chr VII from 938992-937124, reverse complement, Verified ORF, "Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p"
>YGR222W PET54 SGDID:S000003454, Chr VII from 939923-940804, Verified ORF, "Mitochondrial inner membrane protein that binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing"
>YGR223C HSV2 SGDID:S000003455, Chr VII from 942215-940869, reverse complement, Verified ORF, "Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization"
>YGR224W AZR1 SGDID:S000003456, Chr VII from 942806-944647, Verified ORF, "Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole"
>YGR225W AMA1 SGDID:S000003457, Chr VII from 945145-946327,946421-947019, Verified ORF, "Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis"
>YGR226C YGR226C SGDID:S000003458, Chr VII from 947001-946792, reverse complement, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W"
>YGR227W DIE2 SGDID:S000003459, Chr VII from 947420-948997, Verified ORF, "Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1"
>YGR228W YGR228W SGDID:S000003460, Chr VII from 949365-949709, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C"
>YGR229C SMI1 SGDID:S000003461, Chr VII from 950899-949382, reverse complement, Verified ORF, "Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity"
>YGR230W BNS1 SGDID:S000003462, Chr VII from 951894-952307, Verified ORF, "Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis"
>YGR231C PHB2 SGDID:S000003463, Chr VII from 953480-952548, reverse complement, Verified ORF, "Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation"
>YGR232W NAS6 SGDID:S000003464, Chr VII from 953960-954646, Verified ORF, "Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6"
>YGR233C PHO81 SGDID:S000003465, Chr VII from 958210-954674, reverse complement, Verified ORF, "Cyclin-dependent kinase (CDK) inhibitor, regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p"
>YGR234W YHB1 SGDID:S000003466, Chr VII from 959904-961103, Verified ORF, "Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses"
>YGR235C YGR235C SGDID:S000003467, Chr VII from 962061-961360, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YGR236C SPG1 SGDID:S000003468, Chr VII from 962817-962530, reverse complement, Verified ORF, "Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YGR237C YGR237C SGDID:S000003469, Chr VII from 965655-963298, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"
>YGR238C KEL2 SGDID:S000003470, Chr VII from 968687-966039, reverse complement, Verified ORF, "Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate"
>YGR239C PEX21 SGDID:S000003471, Chr VII from 970053-969187, reverse complement, Verified ORF, "Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex18p"
>YGR240C PFK1 SGDID:S000003472, Chr VII from 973734-970771, reverse complement, Verified ORF, "Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes"
>YGR240C-A YGR240C-A SGDID:S000028551, Chr VII from 974777-974577, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by fungal homology and RT-PCR"
>YGR241C YAP1802 SGDID:S000003473, Chr VII from 976581-974875, reverse complement, Verified ORF, "Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family"
>YGR242W YGR242W SGDID:S000003474, Chr VII from 976415-976723, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C"
>YGR243W FMP43 SGDID:S000003475, Chr VII from 977336-977776, Uncharacterized ORF, "Putative protein of unknown function; expression regulated by osmotic and alkaline stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YGR244C LSC2 SGDID:S000003476, Chr VII from 979319-978036, reverse complement, Verified ORF, "Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate"
>YGR245C SDA1 SGDID:S000003477, Chr VII from 982068-979765, reverse complement, Verified ORF, "Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis"
>YGR246C BRF1 SGDID:S000003478, Chr VII from 984272-982482, reverse complement, Verified ORF, "TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB"
>YGR247W CPD1 SGDID:S000003479, Chr VII from 984966-985685, Verified ORF, "Cyclic nucleotide phosphodiesterase, hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression"
>YGR248W SOL4 SGDID:S000003480, Chr VII from 985972-986739, Verified ORF, "6-phosphogluconolactonase with similarity to Sol3p"
>YGR249W MGA1 SGDID:S000003481, Chr VII from 988049-989419, Verified ORF, "Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants"
>YGR250C YGR250C SGDID:S000003482, Chr VII from 993521-991176, reverse complement, Verified ORF, "Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid"
>YGR251W YGR251W SGDID:S000003483, Chr VII from 995639-996229, Verified ORF, "Essential protein required for maturation of 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus"
>YGR252W GCN5 SGDID:S000003484, Chr VII from 996869-998188, Verified ORF, "Histone acetyltransferase, acetylates N-terminal lysines on histones H2B and H3; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; founding member of the Gcn5p-related N-acetyltransferase superfamily"
>YGR253C PUP2 SGDID:S000003485, Chr VII from 999140-998358, reverse complement, Verified ORF, "Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta"
>YGR254W ENO1 SGDID:S000003486, Chr VII from 1000927-1002240, Verified ORF, "Enolase I, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose"
>YGR255C COQ6 SGDID:S000003487, Chr VII from 1003962-1002523, reverse complement, Verified ORF, "Putative flavin-dependent monooxygenase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes"
>YGR256W GND2 SGDID:S000003488, Chr VII from 1004624-1006102, Verified ORF, "6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone"
>YGR257C MTM1 SGDID:S000003489, Chr VII from 1007305-1006205, reverse complement, Verified ORF, "Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor"
>YGR258C RAD2 SGDID:S000003490, Chr VII from 1010766-1007671, reverse complement, Verified ORF, "Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein"
>YGR259C YGR259C SGDID:S000003491, Chr VII from 1012921-1012481, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W"
>YGR260W TNA1 SGDID:S000003492, Chr VII from 1012485-1014089, Verified ORF, "High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)"
>YGR261C APL6 SGDID:S000003493, Chr VII from 1016750-1014321, reverse complement, Verified ORF, "Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools"
>YGR262C BUD32 SGDID:S000003494, Chr VII from 1017759-1016974, reverse complement, Verified ORF, "Protein kinase proposed to be involved in bud-site selection, telomere uncapping and elongation, and transcription; component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Gon7p"
>YGR263C SAY1 SGDID:S000003495, Chr VII from 1019241-1017967, reverse complement, Verified ORF, "Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum"
>YGR264C MES1 SGDID:S000003496, Chr VII from 1021853-1019598, reverse complement, Verified ORF, "Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs"
>YGR265W YGR265W SGDID:S000003497, Chr VII from 1021648-1022058, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase"
>YGR266W YGR266W SGDID:S000003498, Chr VII from 1022656-1024761, Verified ORF, "Protein of unknown function, predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane"
>YGR267C FOL2 SGDID:S000003499, Chr VII from 1025735-1025004, reverse complement, Verified ORF, "GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway"
>YGR268C HUA1 SGDID:S000003500, Chr VII from 1026653-1026057, reverse complement, Verified ORF, "Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly"
>YGR269W YGR269W SGDID:S000003501, Chr VII from 1026636-1026962, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF HUA1/YGR268C"
>YGR270C-A YGR270C-A SGDID:S000028641, Chr VII from 1027600-1027382, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF YTA7/YGR270W"
>YGR270W YTA7 SGDID:S000003502, Chr VII from 1027370-1031509, Verified ORF, "Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p"
>YGR271C-A EFG1 SGDID:S000007608, Chr VII from 1038501-1037800, reverse complement, Verified ORF, "Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus"
>YGR271W SLH1 SGDID:S000003503, Chr VII from 1031791-1037694, Verified ORF, "Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses"
>YGR273C YGR273C SGDID:S000003505, Chr VII from 1039239-1038715, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene"
>YGR274C TAF1 SGDID:S000003506, Chr VII from 1043095-1039895, reverse complement, Verified ORF, "TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression"
>YGR275W RTT102 SGDID:S000003507, Chr VII from 1043276-1043749, Verified ORF, "Component of both the SWI/SNF and RSC chromatin remodeling complexes, suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition"
>YGR276C RNH70 SGDID:S000003508, Chr VII from 1045480-1043819, reverse complement, Verified ORF, "3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts"
>YGR277C CAB4 SGDID:S000003509, Chr VII from 1046561-1045644, reverse complement, Verified ORF, "Probable pantetheine-phosphate adenylyltransferase (PPAT), which catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT); widely conserved"
>YGR278W CWC22 SGDID:S000003510, Chr VII from 1046731-1048464, Verified ORF, "Essential protein, component of a complex containing Cef1p, has similarity to S. pombe Cwf22p; putative spliceosomal component, based on computational analysis of large-scale protein-protein interaction data"
>YGR279C SCW4 SGDID:S000003511, Chr VII from 1049958-1048798, reverse complement, Verified ORF, "Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating"
>YGR280C PXR1 SGDID:S000003512, Chr VII from 1051725-1050910, reverse complement, Verified ORF, "Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain"
>YGR281W YOR1 SGDID:S000003513, Chr VII from 1052824-1057257, Verified ORF, "Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin; similar to human cystic fibrosis transmembrane receptor (CFTR)"
>YGR282C BGL2 SGDID:S000003514, Chr VII from 1058724-1057783, reverse complement, Verified ORF, "Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance"
>YGR283C YGR283C SGDID:S000003515, Chr VII from 1060040-1059015, reverse complement, Verified ORF, "Protein of unknown function; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; null mutant is resistant to fluconazole; GFP-fusion protein localizes to the nucleolus"
>YGR284C ERV29 SGDID:S000003516, Chr VII from 1061590-1060658, reverse complement, Verified ORF, "Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo"
>YGR285C ZUO1 SGDID:S000003517, Chr VII from 1063153-1061852, reverse complement, Verified ORF, "Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p"
>YGR286C BIO2 SGDID:S000003518, Chr VII from 1064940-1063813, reverse complement, Verified ORF, "Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant"
>YGR287C IMA1 SGDID:S000003519, Chr VII from 1068991-1067222, reverse complement, Verified ORF, "Major isomaltase (alpha-1,6-glucosidase) required for isomaltose utilization; has specificity for isomaltose, palatinose, and methyl-alpha-glucoside; member of the IMA isomaltase family"
>YGR288W MAL13 SGDID:S000003520, Chr VII from 1070293-1071714, Verified ORF, "MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C"
>YGR289C MAL11 SGDID:S000003521, Chr VII from 1075813-1073963, reverse complement, Verified ORF, "Inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization"
>YGR290W YGR290W SGDID:S000003522, Chr VII from 1075482-1075925, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter)"
>YGR291C YGR291C SGDID:S000003523, Chr VII from 1076504-1076283, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YGR292W MAL12 SGDID:S000003524, Chr VII from 1076599-1078353, Verified ORF, "Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose"
>YGR293C YGR293C SGDID:S000003525, Chr VII from 1080346-1079885, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YGR294W"
>YGR294W PAU12 SGDID:S000003526, Chr VII from 1080306-1080668, Verified ORF, "Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions"
>YGR295C COS6 SGDID:S000003527, Chr VII from 1082729-1081584, reverse complement, Verified ORF, "Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins"
>YGR296C-A YGR296C-A SGDID:S000028642, Chr VII from 1089445-1088870, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL07R"
>YGR296C-B YGR296C-B SGDID:S000028643, Chr VII from 1090228-1089746, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; contained completely within TEL07R"
>YGR296W YRF1-3 SGDID:S000003528, Chr VII from 1084864-1084882,1085031-1090591, Verified ORF, "Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p"
>YHL001W RPL14B SGDID:S000000993, Chr VIII from 104277-104405,104804-105091, Verified ORF, "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Ap and has similarity to rat L14 ribosomal protein"
>YHL002C-A YHL002C-A SGDID:S000028770, Chr VIII from 103075-102587, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YHL002W HSE1 SGDID:S000000994, Chr VIII from 102612-103970, Verified ORF, "Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes"
>YHL003C LAG1 SGDID:S000000995, Chr VIII from 101883-100648, reverse complement, Verified ORF, "Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p"
>YHL004W MRP4 SGDID:S000000996, Chr VIII from 99219-100403, Verified ORF, "Mitochondrial ribosomal protein of the small subunit"
>YHL005C YHL005C SGDID:S000000997, Chr VIII from 99220-98828, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YHL004W"
>YHL006C SHU1 SGDID:S000000998, Chr VIII from 98795-98343, reverse complement, Verified ORF, "Protein involved in a Rad51p-, Rad54p-dependent pathway for homologous recombination repair, important for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation; associates with Shu2p, Psy3p, and Csm2p"
>YHL006W-A YHL006W-A SGDID:S000028771, Chr VIII from 97732-98085, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YHL007C STE20 SGDID:S000000999, Chr VIII from 97937-95118, reverse complement, Verified ORF, "Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p"
>YHL008C YHL008C SGDID:S000001000, Chr VIII from 94510-92627, reverse complement, Uncharacterized ORF, "Putative protein of unknown function, may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole"
>YHL009C YAP3 SGDID:S000001001, Chr VIII from 85060-84068, reverse complement, Verified ORF, "Basic leucine zipper (bZIP) transcription factor"
>YHL009W-A YHL009W-A SGDID:S000007371, Chr VIII from 85909-87150, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YHL009W-B YHL009W-B SGDID:S000007372, Chr VIII from 85909-86994,86996-91318, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YHL010C ETP1 SGDID:S000001002, Chr VIII from 83721-81964, reverse complement, Verified ORF, "Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences"
>YHL011C PRS3 SGDID:S000001003, Chr VIII from 81616-80654, reverse complement, Verified ORF, "5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes"
>YHL012W YHL012W SGDID:S000001004, Chr VIII from 78936-80417, Uncharacterized ORF, "Putative protein of unknown function, has some homology to Ugp1p, which encodes UDP-glucose pyrophosphorylase"
>YHL013C OTU2 SGDID:S000001005, Chr VIII from 78353-77430, reverse complement, Verified ORF, "Protein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization"
>YHL014C YLF2 SGDID:S000001006, Chr VIII from 77314-76097, reverse complement, Verified ORF, "Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YHL015W RPS20 SGDID:S000001007, Chr VIII from 75412-75777, Verified ORF, "Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins"
>YHL015W-A YHL015W-A SGDID:S000028828, Chr VIII from 74699-74782, Uncharacterized ORF, "Putative protein of unknown function"
>YHL016C DUR3 SGDID:S000001008, Chr VIII from 74244-72037, reverse complement, Verified ORF, "Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway"
>YHL017W YHL017W SGDID:S000001009, Chr VIII from 70276-71874, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles"
>YHL018W YHL018W SGDID:S000001010, Chr VIII from 69708-70070, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS"
>YHL019C APM2 SGDID:S000001011, Chr VIII from 69548-67731, reverse complement, Verified ORF, "Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport"
>YHL019W-A YHL019W-A SGDID:S000028772, Chr VIII from 67711-68304, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene APM2/YHL019C"
>YHL020C OPI1 SGDID:S000001012, Chr VIII from 67456-66242, reverse complement, Verified ORF, "Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance"
>YHL021C AIM17 SGDID:S000001013, Chr VIII from 65859-64462, reverse complement, Verified ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss"
>YHL022C SPO11 SGDID:S000001014, Chr VIII from 64157-62961, reverse complement, Verified ORF, "Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation"
>YHL023C NPR3 SGDID:S000001015, Chr VIII from 62563-59123, reverse complement, Verified ORF, "Component, with Npr2p, of an evolutionarily conserved complex that mediates downregulation of TOR Complex 1 activity in response to amino acid limitation; null mutant displays delayed meiotic DNA replication and double-strand break repair"
>YHL024W RIM4 SGDID:S000001016, Chr VIII from 56649-58790, Verified ORF, "Putative RNA-binding protein required for the expression of early and middle sporulation genes"
>YHL025W SNF6 SGDID:S000001017, Chr VIII from 54851-55849, Verified ORF, "Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p"
>YHL026C YHL026C SGDID:S000001018, Chr VIII from 54166-53219, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History)"
>YHL027W RIM101 SGDID:S000001019, Chr VIII from 51111-52988, Verified ORF, "Transcriptional repressor involved in response to pH and in cell wall construction; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by proteolytic processing; similar to A. nidulans PacC"
>YHL028W WSC4 SGDID:S000001020, Chr VIII from 48763-50580, Verified ORF, "ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3"
>YHL029C OCA5 SGDID:S000001021, Chr VIII from 47968-45929, reverse complement, Uncharacterized ORF, "Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts"
>YHL030W ECM29 SGDID:S000001022, Chr VIII from 40084-45690, Verified ORF, "Major component of the proteasome; tethers the proteasome core particle to the regulatory particle, and enhances the stability of the proteasome"
>YHL030W-A YHL030W-A SGDID:S000028773, Chr VIII from 39074-39535, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene GOS1/YHL031C"
>YHL031C GOS1 SGDID:S000001023, Chr VIII from 39486-38815, reverse complement, Verified ORF, "v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28"
>YHL032C GUT1 SGDID:S000001024, Chr VIII from 38508-36379, reverse complement, Verified ORF, "Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p"
>YHL033C RPL8A SGDID:S000001025, Chr VIII from 36025-35255, reverse complement, Verified ORF, "Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Bp and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits"
>YHL034C SBP1 SGDID:S000001026, Chr VIII from 34077-33193, reverse complement, Verified ORF, "Putative RNA binding protein; involved in translational repression and found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11"
>YHL034W-A YHL034W-A SGDID:S000028774, Chr VIII from 33176-33637, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YHL035C VMR1 SGDID:S000001027, Chr VIII from 32756-27978, reverse complement, Verified ORF, "Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions"
>YHL036W MUP3 SGDID:S000001028, Chr VIII from 26241-27881, Verified ORF, "Low affinity methionine permease, similar to Mup1p"
>YHL037C YHL037C SGDID:S000001029, Chr VIII from 26179-25778, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YHL038C CBP2 SGDID:S000001030, Chr VIII from 25509-23617, reverse complement, Verified ORF, "Mitochondrial protein required for splicing of the group I intron aI5 of the COB pre-mRNA, binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene"
>YHL039W EFM1 SGDID:S000001031, Chr VIII from 21783-23540, Verified ORF, "Probable lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"
>YHL040C ARN1 SGDID:S000001032, Chr VIII from 20971-19088, reverse complement, Verified ORF, "Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores"
>YHL041W YHL041W SGDID:S000001033, Chr VIII from 17392-17841, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data"
>YHL042W YHL042W SGDID:S000001034, Chr VIII from 15667-16119, Uncharacterized ORF, "Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins"
>YHL043W ECM34 SGDID:S000001035, Chr VIII from 14901-15413, Verified ORF, "Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins"
>YHL044W YHL044W SGDID:S000001036, Chr VIII from 13565-14272, Uncharacterized ORF, "Putative integral membrane protein, member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern"
>YHL045W YHL045W SGDID:S000001037, Chr VIII from 12502-12849, Dubious ORF, "Putative protein of unknown function; not an essential gene"
>YHL046C PAU13 SGDID:S000001038, Chr VIII from 12285-11923, reverse complement, Verified ORF, "Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression is induced after ethanol shock"
>YHL046W-A YHL046W-A SGDID:S000028775, Chr VIII from 9981-10307, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YHL047C ARN2 SGDID:S000001039, Chr VIII from 10213-8351, reverse complement, Verified ORF, "Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C"
>YHL048C-A YHL048C-A SGDID:S000028829, Chr VIII from 5797-5663, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by expression profiling and mass spectrometry"
>YHL048W COS8 SGDID:S000001040, Chr VIII from 6401-7546, Verified ORF, "Nuclear membrane protein, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; regulation suggests a potential role in the unfolded protein response"
>YHL049C YHL049C SGDID:S000001041, Chr VIII from 4541-3726, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YHL050C YHL050C SGDID:S000001042, Chr VIII from 1897-445,3311-2671, reverse complement, Uncharacterized ORF, "Putative protein of unknown function, potential Cdc28p substrate"
>YHL050W-A YHL050W-A SGDID:S000028644, Chr VIII from 811-1293, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YHR001W OSH7 SGDID:S000001043, Chr VIII from 106055-107368, Verified ORF, "Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability"
>YHR001W-A QCR10 SGDID:S000003529, Chr VIII from 107826-107831,107895-108122, Verified ORF, "Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain"
>YHR002W LEU5 SGDID:S000001044, Chr VIII from 108812-109885, Verified ORF, "Mitochondrial carrier protein involved in the accumulation of CoA in the mitochondrial matrix; homolog of human Graves disease protein; does not encode an isozyme of Leu4p, as first hypothesized"
>YHR003C YHR003C SGDID:S000001045, Chr VIII from 111317-110028, reverse complement, Verified ORF, "Protein of unknown function, localized to the mitochondrial outer membrane"
>YHR004C NEM1 SGDID:S000001046, Chr VIII from 113094-111754, reverse complement, Verified ORF, "Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard"
>YHR005C GPA1 SGDID:S000001047, Chr VIII from 114917-113499, reverse complement, Verified ORF, "GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome"
>YHR005C-A TIM10 SGDID:S000003530, Chr VIII from 115901-115620, reverse complement, Verified ORF, "Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane"
>YHR006W STP2 SGDID:S000001048, Chr VIII from 117814-119439, Verified ORF, "Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes"
>YHR007C ERG11 SGDID:S000001049, Chr VIII from 121683-120091, reverse complement, Verified ORF, "Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family"
>YHR007C-A YHR007C-A SGDID:S000028830, Chr VIII from 122765-122550, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by expression profiling and mass spectrometry"
>YHR008C SOD2 SGDID:S000001050, Chr VIII from 123590-122889, reverse complement, Verified ORF, "Mitochondrial superoxide dismutase, protects cells against oxygen toxicity; phosphorylated"
>YHR009C YHR009C SGDID:S000001051, Chr VIII from 125680-124109, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; not an essential gene"
>YHR010W RPL27A SGDID:S000001052, Chr VIII from 126521-126551,127113-127492, Verified ORF, "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein"
>YHR011W DIA4 SGDID:S000001053, Chr VIII from 127780-129120, Verified ORF, "Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth"
>YHR012W VPS29 SGDID:S000001054, Chr VIII from 129481-129528,129648-130448, Verified ORF, "Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval"
>YHR013C ARD1 SGDID:S000001055, Chr VIII from 131446-130730, reverse complement, Verified ORF, "Subunit of N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells"
>YHR014W SPO13 SGDID:S000001056, Chr VIII from 132047-132922, Verified ORF, "Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II"
>YHR015W MIP6 SGDID:S000001057, Chr VIII from 134554-136533, Verified ORF, "Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export"
>YHR016C YSC84 SGDID:S000001058, Chr VIII from 138240-136881,138455-138409, reverse complement, Verified ORF, "Actin-binding protein involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p"
>YHR017W YSC83 SGDID:S000001059, Chr VIII from 138694-139851, Verified ORF, "Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83"
>YHR018C ARG4 SGDID:S000001060, Chr VIII from 141402-140011, reverse complement, Verified ORF, "Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway"
>YHR019C DED81 SGDID:S000001061, Chr VIII from 143558-141894, reverse complement, Verified ORF, "Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA"
>YHR020W YHR020W SGDID:S000001062, Chr VIII from 143996-146062, Verified ORF, "Protein of unknown function that may interact with ribosomes, based on co-purification experiments; has similarity to proline-tRNA ligase; YHR020W is an essential gene"
>YHR021C RPS27B SGDID:S000001063, Chr VIII from 148116-147871,148669-148667, reverse complement, Verified ORF, "Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein"
>YHR021W-A ECM12 SGDID:S000003531, Chr VIII from 149225-149680, Uncharacterized ORF, "Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity"
>YHR022C YHR022C SGDID:S000001064, Chr VIII from 150345-149575, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; YHR022C is not an essential gene"
>YHR022C-A YHR022C-A SGDID:S000028645, Chr VIII from 151306-151217, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YHR023W MYO1 SGDID:S000001065, Chr VIII from 151666-157452, Verified ORF, "Type II myosin heavy chain, required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively"
>YHR024C MAS2 SGDID:S000001066, Chr VIII from 159192-157744, reverse complement, Verified ORF, "Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins"
>YHR025W THR1 SGDID:S000001067, Chr VIII from 159438-160511, Verified ORF, "Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway"
>YHR026W VMA16 SGDID:S000001068, Chr VIII from 160844-161485, Verified ORF, "Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain"
>YHR027C RPN1 SGDID:S000001069, Chr VIII from 164711-161730, reverse complement, Verified ORF, "Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein-protein interactions"
>YHR028C DAP2 SGDID:S000001070, Chr VIII from 167434-164978, reverse complement, Verified ORF, "Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p"
>YHR028W-A YHR028W-A SGDID:S000028776, Chr VIII from 167352-167672, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YHR029C YHI9 SGDID:S000001071, Chr VIII from 168561-167677, reverse complement, Verified ORF, "Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production"
>YHR030C SLT2 SGDID:S000001072, Chr VIII from 170344-168890, reverse complement, Verified ORF, "Serine/threonine MAP kinase involved in regulating the maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; regulated by the PKC1-mediated signaling pathway"
>YHR031C RRM3 SGDID:S000001073, Chr VIII from 172970-170799, reverse complement, Verified ORF, "DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p"
>YHR032C-A YHR032C-A SGDID:S000028646, Chr VIII from 175394-175275, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YHR032W-A"
>YHR032W ERC1 SGDID:S000001074, Chr VIII from 173344-175089, Verified ORF, "Member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine"
>YHR032W-A YHR032W-A SGDID:S000028831, Chr VIII from 175195-175374, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YHR032C-A"
>YHR033W YHR033W SGDID:S000001075, Chr VIII from 175548-176819, Uncharacterized ORF, "Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm"
>YHR034C PIH1 SGDID:S000001076, Chr VIII from 177999-176965, reverse complement, Verified ORF, "Protein of unresolved function; may function in protein folding and/or rRNA processing, interacts with a chaperone (Hsp82p), two chromatin remodeling factors (Rvb1p, Rvb2p) and two rRNA processing factors (Rrp43p, Nop58p)"
>YHR035W YHR035W SGDID:S000001077, Chr VIII from 178219-180111, Uncharacterized ORF, "Putative protein of unknown function; not an essential gene"
>YHR036W BRL1 SGDID:S000001078, Chr VIII from 180345-181760, Verified ORF, "Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export"
>YHR037W PUT2 SGDID:S000001079, Chr VIII from 181977-183704, Verified ORF, "Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism"
>YHR038W RRF1 SGDID:S000001080, Chr VIII from 184066-184758, Verified ORF, "Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria"
>YHR039C MSC7 SGDID:S000001081, Chr VIII from 186809-184875, reverse complement, Verified ORF, "Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids"
>YHR039C-A VMA10 SGDID:S000002100, Chr VIII from 187514-187173,187679-187677, reverse complement, Verified ORF, "Subunit G of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; involved in vacuolar acidification"
>YHR040W BCD1 SGDID:S000001082, Chr VIII from 187924-189024, Verified ORF, "Essential protein required for the accumulation of box C/D snoRNA"
>YHR041C SRB2 SGDID:S000001083, Chr VIII from 189749-189131,189864-189851, reverse complement, Verified ORF, "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance"
>YHR042W NCP1 SGDID:S000001084, Chr VIII from 190543-192618, Verified ORF, "NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p"
>YHR043C DOG2 SGDID:S000001085, Chr VIII from 193545-192805, reverse complement, Verified ORF, "2-deoxyglucose-6-phosphate phosphatase, member of a family of low molecular weight phosphatases, similar to Dog1p, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed"
>YHR044C DOG1 SGDID:S000001086, Chr VIII from 194808-194068, reverse complement, Verified ORF, "2-deoxyglucose-6-phosphate phosphatase, similar to Dog2p, member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified"
>YHR045W YHR045W SGDID:S000001087, Chr VIII from 195551-197233, Uncharacterized ORF, "Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum"
>YHR046C INM1 SGDID:S000001088, Chr VIII from 198285-197398, reverse complement, Verified ORF, "Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate"
>YHR047C AAP1 SGDID:S000001089, Chr VIII from 201310-198740, reverse complement, Verified ORF, "Arginine/alanine aminopeptidase, overproduction stimulates glycogen accumulation"
>YHR048W YHK8 SGDID:S000001090, Chr VIII from 204607-206151, Uncharacterized ORF, "Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles"
>YHR049C-A YHR049C-A SGDID:S000003532, Chr VIII from 207530-207234, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YHR049W FSH1 SGDID:S000001091, Chr VIII from 206462-207193, Verified ORF, "Putative serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2"
>YHR050W SMF2 SGDID:S000001092, Chr VIII from 207654-209303, Verified ORF, "Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins"
>YHR050W-A YHR050W-A SGDID:S000028832, Chr VIII from 209475-209645, Uncharacterized ORF, "Protein of unknown function; identified by expression profiling and mass spectrometry"
>YHR051W COX6 SGDID:S000001093, Chr VIII from 209705-210151, Verified ORF, "Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels"
>YHR052W CIC1 SGDID:S000001094, Chr VIII from 210848-211978, Verified ORF, "Essential protein that interacts with proteasome components and has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles"
>YHR052W-A YHR052W-A SGDID:S000028647, Chr VIII from 212510-212704, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CUP1-1"
>YHR053C CUP1-1 SGDID:S000001095, Chr VIII from 212720-212535, reverse complement, Verified ORF, "Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C"
>YHR054C YHR054C SGDID:S000001096, Chr VIII from 214249-213185, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YHR054W-A YHR054W-A SGDID:S000028648, Chr VIII from 214508-214702, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CUP1-2"
>YHR055C CUP1-2 SGDID:S000001097, Chr VIII from 214718-214533, reverse complement, Verified ORF, "Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C"
>YHR056C RSC30 SGDID:S000001098, Chr VIII from 217834-215183, reverse complement, Verified ORF, "Component of the RSC chromatin remodeling complex; non-essential gene required for regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc3p; null mutants are osmosensitive"
>YHR056W-A YHR056W-A SGDID:S000028777, Chr VIII from 217406-217840, Dubious ORF, "Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YHR057C CPR2 SGDID:S000001099, Chr VIII from 218843-218226, reverse complement, Verified ORF, "Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway"
>YHR058C MED6 SGDID:S000001100, Chr VIII from 219884-218997, reverse complement, Verified ORF, "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation"
>YHR059W FYV4 SGDID:S000001101, Chr VIII from 220108-220500, Verified ORF, "Protein of unknown function, required for survival upon exposure to K1 killer toxin"
>YHR060W VMA22 SGDID:S000001102, Chr VIII from 220725-221270, Verified ORF, "Peripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)"
>YHR061C GIC1 SGDID:S000001103, Chr VIII from 222478-221534, reverse complement, Verified ORF, "Protein of unknown function involved in initiation of budding and cellular polarization, interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain"
>YHR062C RPP1 SGDID:S000001104, Chr VIII from 223758-222877, reverse complement, Verified ORF, "Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends"
>YHR063C PAN5 SGDID:S000001105, Chr VIII from 225169-224030, reverse complement, Verified ORF, "2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE"
>YHR063W-A YHR063W-A SGDID:S000028778, Chr VIII from 225442-225777, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YHR064C SSZ1 SGDID:S000001106, Chr VIII from 227141-225525, reverse complement, Verified ORF, "Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP"
>YHR065C RRP3 SGDID:S000001107, Chr VIII from 229037-227532, reverse complement, Verified ORF, "Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity"
>YHR066W SSF1 SGDID:S000001108, Chr VIII from 229335-230696, Verified ORF, "Constituent of 66S pre-ribosomal particles, required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family"
>YHR067W HTD2 SGDID:S000001109, Chr VIII from 230970-231812, Verified ORF, "Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology"
>YHR068W DYS1 SGDID:S000001110, Chr VIII from 232133-233296, Verified ORF, "Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric"
>YHR069C RRP4 SGDID:S000001111, Chr VIII from 234658-233579, reverse complement, Verified ORF, "Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2)"
>YHR069C-A YHR069C-A SGDID:S000028779, Chr VIII from 235236-234874, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YHR070C-A YHR070C-A SGDID:S000028780, Chr VIII from 236512-236102, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene TRM5/YHR070W"
>YHR070W TRM5 SGDID:S000001112, Chr VIII from 234881-236380, Verified ORF, "tRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and Eukarya"
>YHR071C-A YHR071C-A SGDID:S000028781, Chr VIII from 239230-238910, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF ERG7/YHR072W"
>YHR071W PCL5 SGDID:S000001113, Chr VIII from 237004-237693, Verified ORF, "Cyclin, interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity"
>YHR072W ERG7 SGDID:S000001114, Chr VIII from 239098-241293, Verified ORF, "Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis"
>YHR072W-A NOP10 SGDID:S000007455, Chr VIII from 241664-241840, Verified ORF, "Constituent of small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs, which are required for pseudouridylation and processing of pre-18S rRNA"
>YHR073C-B YHR073C-B SGDID:S000028833, Chr VIII from 245502-245422, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF YHR073W; identified by expression profiling and mass spectrometry"
>YHR073W OSH3 SGDID:S000001115, Chr VIII from 242582-245572, Verified ORF, "Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability"
>YHR073W-A YHR073W-A SGDID:S000028834, Chr VIII from 242868-243044, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF YHR073W; identified by expression profiling and mass spectrometry"
>YHR074W QNS1 SGDID:S000001116, Chr VIII from 246193-248337, Verified ORF, "Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide"
>YHR075C PPE1 SGDID:S000001117, Chr VIII from 249641-248439, reverse complement, Verified ORF, "Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein"
>YHR076W PTC7 SGDID:S000001118, Chr VIII from 251101-251155,251249-252225, Verified ORF, "Type 2C protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope"
>YHR077C NMD2 SGDID:S000001119, Chr VIII from 255637-252374,255756-255751, reverse complement, Verified ORF, "Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance"
>YHR078W YHR078W SGDID:S000001120, Chr VIII from 256360-258018, Uncharacterized ORF, "High osmolarity-regulated gene of unknown function"
>YHR079C IRE1 SGDID:S000001121, Chr VIII from 261591-258244, reverse complement, Verified ORF, "Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress"
>YHR079C-A SAE3 SGDID:S000001957, Chr VIII from 262354-262192,262553-262441, reverse complement, Verified ORF, "Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p"
>YHR080C YHR080C SGDID:S000001122, Chr VIII from 266838-262801, reverse complement, Verified ORF, "Protein of unknown function that may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YHR081W LRP1 SGDID:S000001123, Chr VIII from 267538-268092, Verified ORF, "Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination"
>YHR082C KSP1 SGDID:S000001124, Chr VIII from 271548-268459, reverse complement, Verified ORF, "Ser/thr protein kinase; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10"
>YHR083W SAM35 SGDID:S000001125, Chr VIII from 272627-273616, Verified ORF, "Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane"
>YHR084W STE12 SGDID:S000001126, Chr VIII from 274174-276240, Verified ORF, "Transcription factor that is activated by a MAP kinase signaling cascade, activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth"
>YHR085W IPI1 SGDID:S000001127, Chr VIII from 276764-277768, Verified ORF, "Essential component of the Rix1 complex (with Rix1p and Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles"
>YHR086W NAM8 SGDID:S000001128, Chr VIII from 278153-279724, Verified ORF, "RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of MER2 pre-mRNA"
>YHR086W-A YHR086W-A SGDID:S000028552, Chr VIII from 280231-280392, Uncharacterized ORF, "Putative protein of unknown function; identified by fungal homology and RT-PCR"
>YHR087W RTC3 SGDID:S000001129, Chr VIII from 280820-281155, Verified ORF, "Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity"
>YHR088W RPF1 SGDID:S000001130, Chr VIII from 281495-282382, Verified ORF, "Nucleolar protein involved in the assembly and export of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA"
>YHR089C GAR1 SGDID:S000001131, Chr VIII from 283298-282681, reverse complement, Verified ORF, "Protein component of the H/ACA snoRNP pseudouridylase complex, involved in the modification and cleavage of the 18S pre-rRNA"
>YHR090C YNG2 SGDID:S000001132, Chr VIII from 284625-283777, reverse complement, Verified ORF, "Subunit of the NuA4 histone acetyltransferase complex that acetylates histone H4 and H2A; has similarity to the human tumor suppressor ING1 and its isoforms ING4 and ING5"
>YHR091C MSR1 SGDID:S000001133, Chr VIII from 286770-284839, reverse complement, Verified ORF, "Mitochondrial arginyl-tRNA synthetase"
>YHR092C HXT4 SGDID:S000001134, Chr VIII from 288811-287081, reverse complement, Verified ORF, "High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose"
>YHR093W AHT1 SGDID:S000001135, Chr VIII from 289142-289690, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region"
>YHR094C HXT1 SGDID:S000001136, Chr VIII from 292625-290913, reverse complement, Verified ORF, "Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting"
>YHR095W YHR095W SGDID:S000001137, Chr VIII from 292943-293437, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YHR096C HXT5 SGDID:S000001138, Chr VIII from 296447-294669, reverse complement, Verified ORF, "Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs"
>YHR097C YHR097C SGDID:S000001139, Chr VIII from 298360-297385,298609-298485, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus"
>YHR098C SFB3 SGDID:S000001140, Chr VIII from 301934-299145, reverse complement, Verified ORF, "Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p"
>YHR099W TRA1 SGDID:S000001141, Chr VIII from 302761-313995, Verified ORF, "Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation"
>YHR100C GEP4 SGDID:S000001142, Chr VIII from 314673-314116, reverse complement, Verified ORF, "Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase), dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT"
>YHR101C BIG1 SGDID:S000001143, Chr VIII from 315771-314874,315968-315859, reverse complement, Verified ORF, "Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan"
>YHR102W KIC1 SGDID:S000001144, Chr VIII from 316572-319814, Verified ORF, "Protein kinase of the PAK/Ste20 kinase family, required for cell integrity possibly through regulating 1,6-beta-glucan levels in the wall; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body"
>YHR103W SBE22 SGDID:S000001145, Chr VIII from 320414-322972, Verified ORF, "Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth"
>YHR104W GRE3 SGDID:S000001146, Chr VIII from 323409-324392, Verified ORF, "Aldose reductase involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway"
>YHR105W YPT35 SGDID:S000001147, Chr VIII from 324766-325410, Verified ORF, "Endosomal protein of unknown function that contains a phox (PX) homology domain and binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport"
>YHR106W TRR2 SGDID:S000001148, Chr VIII from 325598-326626, Verified ORF, "Mitochondrial thioredoxin reductase involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD"
>YHR107C CDC12 SGDID:S000001149, Chr VIII from 328036-326813, reverse complement, Verified ORF, "Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM"
>YHR108W GGA2 SGDID:S000001150, Chr VIII from 328303-330060, Verified ORF, "Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin"
>YHR109W CTM1 SGDID:S000001151, Chr VIII from 330310-332067, Verified ORF, "Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth"
>YHR110W ERP5 SGDID:S000001152, Chr VIII from 332282-332920, Verified ORF, "Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport"
>YHR111W UBA4 SGDID:S000001153, Chr VIII from 333072-334394, Verified ORF, "Protein that activates Urm1p before its conjugation to proteins (urmylation); also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p"
>YHR112C YHR112C SGDID:S000001154, Chr VIII from 335663-334527, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"
>YHR113W YHR113W SGDID:S000001155, Chr VIII from 336337-337809, Verified ORF, "Cytoplasmic aspartyl aminopeptidase; cleaves unblocked N-terminal acidic amino acid residues from peptide substrates; forms a 12 subunit homo-oligomeric complex; M18 metalloprotease family member; may interact with ribosomes"
>YHR114W BZZ1 SGDID:S000001156, Chr VIII from 338083-339984, Verified ORF, "SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins"
>YHR115C DMA1 SGDID:S000001157, Chr VIII from 341359-340109, reverse complement, Verified ORF, "Protein involved in ubiquitin ligation; plays a role in regulating spindle position and orientation; functionally redundant with Dma2p; orthologous to human RNF8 protein, also has sequence similarity to human Chfr."
>YHR116W COX23 SGDID:S000001158, Chr VIII from 341665-342120, Verified ORF, "Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs"
>YHR117W TOM71 SGDID:S000001159, Chr VIII from 342349-344268, Verified ORF, "Mitochondrial outer membrane protein with similarity to Tom70p; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins"
>YHR118C ORC6 SGDID:S000001160, Chr VIII from 345628-344321, reverse complement, Verified ORF, "Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p"
>YHR119W SET1 SGDID:S000001161, Chr VIII from 346043-349285, Verified ORF, "Histone methyltransferase, subunit of the COMPASS (Set1C) complex which methylates histone H3 on lysine 4; required in transcriptional silencing near telomeres and at the silent mating type loci; contains a SET domain"
>YHR120W MSH1 SGDID:S000001162, Chr VIII from 349574-352453, Verified ORF, "DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis"
>YHR121W LSM12 SGDID:S000001163, Chr VIII from 352756-353319, Verified ORF, "Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS"
>YHR122W YHR122W SGDID:S000001164, Chr VIII from 353625-354320, Verified ORF, "Protein of unknown function required for establishment of sister chromatid cohesion; synthetically lethal with RFC5, an RF-C subunit that links replication to cohesion establishment; YHR122W is an essential gene"
>YHR123W EPT1 SGDID:S000001165, Chr VIII from 354815-354864,354956-356081, Verified ORF, "sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability"
>YHR124W NDT80 SGDID:S000001166, Chr VIII from 356561-358444, Verified ORF, "Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE)"
>YHR125W YHR125W SGDID:S000001167, Chr VIII from 358858-359163, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YHR126C ANS1 SGDID:S000001168, Chr VIII from 360181-359702, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; transcription dependent upon Azf1p"
>YHR127W YHR127W SGDID:S000001169, Chr VIII from 360913-361644, Verified ORF, "Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis"
>YHR128W FUR1 SGDID:S000001170, Chr VIII from 362115-362765, Verified ORF, "Uracil phosphoribosyltransferase, synthesizes UMP from uracil; involved in the pyrimidine salvage pathway"
>YHR129C ARP1 SGDID:S000001171, Chr VIII from 364153-362999, reverse complement, Verified ORF, "Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin"
>YHR130C YHR130C SGDID:S000001172, Chr VIII from 365300-364965, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YHR131C YHR131C SGDID:S000001173, Chr VIII from 367892-365340, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; overexpression causes a cell cycle delay or arrest"
>YHR131W-A YHR131W-A SGDID:S000028782, Chr VIII from 367747-367992, Dubious ORF, "Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YHR131C"
>YHR132C ECM14 SGDID:S000001174, Chr VIII from 369794-368502, reverse complement, Verified ORF, "Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly"
>YHR132W-A IGO2 SGDID:S000007496, Chr VIII from 370054-370449, Verified ORF, "Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo1p"
>YHR133C NSG1 SGDID:S000001175, Chr VIII from 371597-370722, reverse complement, Verified ORF, "Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins"
>YHR134W WSS1 SGDID:S000001176, Chr VIII from 371749-372558, Verified ORF, "Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response"
>YHR135C YCK1 SGDID:S000001177, Chr VIII from 374310-372694, reverse complement, Verified ORF, "Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck2p"
>YHR136C SPL2 SGDID:S000001178, Chr VIII from 375100-374654, reverse complement, Verified ORF, "Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation; overproduction suppresses a plc1 null mutation; GFP-fusion protein localizes to the cytoplasm"
>YHR137C-A YHR137C-A SGDID:S000028649, Chr VIII from 376388-375738, reverse complement, Dubious ORF, "Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene ARO9/YHR137W; identified by gene-trapping, expression analysis, and genome-wide homology searching"
>YHR137W ARO9 SGDID:S000001179, Chr VIII from 375709-377250, Verified ORF, "Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism"
>YHR138C YHR138C SGDID:S000001180, Chr VIII from 377699-377355, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; has similarity to Pbi2p; double null mutant lacking Pbi2p and Yhr138p exhibits highly fragmented vacuoles"
>YHR139C SPS100 SGDID:S000001181, Chr VIII from 379199-378219, reverse complement, Verified ORF, "Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin"
>YHR139C-A YHR139C-A SGDID:S000003533, Chr VIII from 380419-380108, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YHR140W YHR140W SGDID:S000001182, Chr VIII from 380572-381291, Uncharacterized ORF, "Putative integral membrane protein of unknown function"
>YHR141C RPL42B SGDID:S000001183, Chr VIII from 382306-381990,382751-382748, reverse complement, Verified ORF, "Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus"
>YHR142W CHS7 SGDID:S000001184, Chr VIII from 383538-384488, Verified ORF, "Protein of unknown function, involved in chitin biosynthesis by regulating Chs3p export from the ER"
>YHR143W DSE2 SGDID:S000001186, Chr VIII from 385510-386487, Verified ORF, "Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP"
>YHR143W-A RPC10 SGDID:S000001185, Chr VIII from 387233-387445, Verified ORF, "RNA polymerase subunit ABC10-alpha, found in RNA polymerase complexes I, II, and III"
>YHR144C DCD1 SGDID:S000001187, Chr VIII from 388726-387788, reverse complement, Verified ORF, "Deoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis; expression is NOT cell cycle regulated"
>YHR145C YHR145C SGDID:S000001188, Chr VIII from 389337-388981, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YHR146W CRP1 SGDID:S000001189, Chr VIII from 390300-391697, Verified ORF, "Protein that binds to cruciform DNA structures"
>YHR147C MRPL6 SGDID:S000001190, Chr VIII from 393283-392639, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the large subunit"
>YHR148W IMP3 SGDID:S000001191, Chr VIII from 393534-394085, Verified ORF, "Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA"
>YHR149C SKG6 SGDID:S000001192, Chr VIII from 396659-394455, reverse complement, Verified ORF, "Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p"
>YHR150W PEX28 SGDID:S000001193, Chr VIII from 397251-398990, Verified ORF, "Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p"
>YHR151C MTC6 SGDID:S000001194, Chr VIII from 400848-399268, reverse complement, Verified ORF, "Protein of unknown function; mtc6 is synthetically sick with cdc13-1"
>YHR152W SPO12 SGDID:S000001195, Chr VIII from 401434-401955, Verified ORF, "Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis"
>YHR153C SPO16 SGDID:S000001196, Chr VIII from 402682-402086, reverse complement, Verified ORF, "Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation"
>YHR154W RTT107 SGDID:S000001197, Chr VIII from 402966-406178, Verified ORF, "Protein implicated in Mms22-dependent DNA repair during S phase, DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition"
>YHR155W YSP1 SGDID:S000001198, Chr VIII from 407103-410789, Verified ORF, "Mitochondrial protein with a potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone"
>YHR156C LIN1 SGDID:S000001199, Chr VIII from 412406-411384, reverse complement, Verified ORF, "Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication"
>YHR157W REC104 SGDID:S000001200, Chr VIII from 412907-413455, Verified ORF, "Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination"
>YHR158C KEL1 SGDID:S000001201, Chr VIII from 417179-413685, reverse complement, Verified ORF, "Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate"
>YHR159W YHR159W SGDID:S000001202, Chr VIII from 417549-419063, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate"
>YHR160C PEX18 SGDID:S000001203, Chr VIII from 420072-419221, reverse complement, Verified ORF, "Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p"
>YHR161C YAP1801 SGDID:S000001204, Chr VIII from 422286-420373, reverse complement, Verified ORF, "Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1802p, member of the AP180 protein family"
>YHR162W YHR162W SGDID:S000001205, Chr VIII from 423072-423461, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion"
>YHR163W SOL3 SGDID:S000001206, Chr VIII from 423724-424473, Verified ORF, "6-phosphogluconolactonase, catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p"
>YHR164C DNA2 SGDID:S000001207, Chr VIII from 429178-424610, reverse complement, Verified ORF, "Tripartite DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization"
>YHR165C PRP8 SGDID:S000001208, Chr VIII from 436948-429707, reverse complement, Verified ORF, "Component of the U4/U6-U5 snRNP complex, involved in the second catalytic step of splicing; mutations of human Prp8 cause retinitis pigmentosa"
>YHR165W-A YHR165W-A SGDID:S000028783, Chr VIII from 436647-436958, Dubious ORF, "Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YHR166C CDC23 SGDID:S000001209, Chr VIII from 439050-437170, reverse complement, Verified ORF, "Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition"
>YHR167W THP2 SGDID:S000001210, Chr VIII from 439342-440127, Verified ORF, "Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance"
>YHR168W MTG2 SGDID:S000001211, Chr VIII from 440377-441933, Verified ORF, "Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly"
>YHR169W DBP8 SGDID:S000001212, Chr VIII from 442181-443476, Verified ORF, "ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p"
>YHR170W NMD3 SGDID:S000001213, Chr VIII from 443828-445384, Verified ORF, "Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex"
>YHR171W ATG7 SGDID:S000001214, Chr VIII from 445713-447605, Verified ORF, "Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation"
>YHR172W SPC97 SGDID:S000001215, Chr VIII from 448335-450806, Verified ORF, "Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque"
>YHR173C YHR173C SGDID:S000001216, Chr VIII from 451153-450815, reverse complement, Dubious ORF, "Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YHR174W ENO2 SGDID:S000001217, Chr VIII from 451327-452640, Verified ORF, "Enolase II, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is induced in response to glucose"
>YHR175W CTR2 SGDID:S000001218, Chr VIII from 452872-453441, Verified ORF, "Putative low-affinity copper transporter of the vacuolar membrane; mutation confers resistance to toxic copper concentrations, while overexpression confers resistance to copper starvation"
>YHR175W-A YHR175W-A SGDID:S000028553, Chr VIII from 453558-453707, Uncharacterized ORF, "Putative protein of unknown function; identified by fungal homology and RT-PCR"
>YHR176W FMO1 SGDID:S000001219, Chr VIII from 454229-455527, Verified ORF, "Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins"
>YHR177W YHR177W SGDID:S000001220, Chr VIII from 456591-457952, Uncharacterized ORF, "Putative protein of unknown function; overexpression causes a cell cycle delay or arrest"
>YHR178W STB5 SGDID:S000001221, Chr VIII from 459299-461530, Verified ORF, "Transcription factor, involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro"
>YHR179W OYE2 SGDID:S000001222, Chr VIII from 462502-463704, Verified ORF, "Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death"
>YHR180C-B YHR180C-B SGDID:S000028554, Chr VIII from 467062-466958, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YHR180W-A"
>YHR180W YHR180W SGDID:S000001223, Chr VIII from 465178-465669, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YHR180W-A YHR180W-A SGDID:S000028555, Chr VIII from 466932-467114, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3"
>YHR181W SVP26 SGDID:S000001224, Chr VIII from 467228-467914, Verified ORF, "Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment"
>YHR182C-A YHR182C-A SGDID:S000028784, Chr VIII from 471412-470939, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YHR182W YHR182W SGDID:S000001225, Chr VIII from 468219-470576, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm"
>YHR183W GND1 SGDID:S000001226, Chr VIII from 470960-472429, Verified ORF, "6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress"
>YHR184W SSP1 SGDID:S000001227, Chr VIII from 472744-474459, Verified ORF, "Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis"
>YHR185C PFS1 SGDID:S000001228, Chr VIII from 475340-474627, reverse complement, Verified ORF, "Sporulation protein required for prospore membrane formation at selected spindle poles, ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation"
>YHR186C KOG1 SGDID:S000001229, Chr VIII from 480672-475999, reverse complement, Verified ORF, "Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors"
>YHR187W IKI1 SGDID:S000001230, Chr VIII from 480990-481919, Verified ORF, "Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin"
>YHR188C GPI16 SGDID:S000001231, Chr VIII from 483837-482005, reverse complement, Verified ORF, "Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog"
>YHR189W PTH1 SGDID:S000001232, Chr VIII from 484028-484600, Verified ORF, "One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium"
>YHR190W ERG9 SGDID:S000001233, Chr VIII from 484845-486179, Verified ORF, "Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway"
>YHR191C CTF8 SGDID:S000001234, Chr VIII from 486631-486230, reverse complement, Verified ORF, "Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion"
>YHR192W YHR192W SGDID:S000001235, Chr VIII from 486826-487662, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS"
>YHR193C EGD2 SGDID:S000001236, Chr VIII from 488236-487712, reverse complement, Verified ORF, "Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes"
>YHR193C-A YHR193C-A SGDID:S000028785, Chr VIII from 489027-488653, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified ORF MDM31"
>YHR194W MDM31 SGDID:S000001237, Chr VIII from 488657-490396, Verified ORF, "Mitochondrial inner membrane protein with similarity to Mdm32p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34"
>YHR195W NVJ1 SGDID:S000001238, Chr VIII from 490747-491712, Verified ORF, "Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN)"
>YHR196W UTP9 SGDID:S000001239, Chr VIII from 491931-493658, Verified ORF, "Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA"
>YHR197W RIX1 SGDID:S000001240, Chr VIII from 493896-496187, Verified ORF, "Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles"
>YHR198C AIM18 SGDID:S000001241, Chr VIII from 497280-496315, reverse complement, Verified ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss"
>YHR199C AIM46 SGDID:S000001242, Chr VIII from 498422-497490, reverse complement, Verified ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss"
>YHR199C-A NBL1 SGDID:S000029704, Chr VIII from 498719-498571,498859-498787, reverse complement, Verified ORF, "Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates mitotic chromosome segregation; not required for the kinase activity of the complex; mediates the interaction of Sli15p and Bir1p"
>YHR200W RPN10 SGDID:S000001243, Chr VIII from 499079-499885, Verified ORF, "Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein"
>YHR201C PPX1 SGDID:S000001244, Chr VIII from 501143-499950, reverse complement, Verified ORF, "Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix"
>YHR202W YHR202W SGDID:S000001245, Chr VIII from 502388-504196, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization"
>YHR203C RPS4B SGDID:S000001246, Chr VIII from 505247-504476,505530-505517, reverse complement, Verified ORF, "Protein component of the small (40S) ribosomal subunit; identical to Rps4Ap and has similarity to rat S4 ribosomal protein"
>YHR204W MNL1 SGDID:S000001247, Chr VIII from 506319-508709, Verified ORF, "alpha-1,2-specific exomannosidase of the endoplasmic reticulum that generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation"
>YHR205W SCH9 SGDID:S000001248, Chr VIII from 509363-511837, Verified ORF, "Protein kinase involved in transcriptional activation of osmostress-responsive genes; regulates G1 progression, cAPK activity, nitrogen activation of the FGM pathway; involved in life span regulation; homologous to mammalian Akt/PKB"
>YHR206W SKN7 SGDID:S000001249, Chr VIII from 512732-514600, Verified ORF, "Nuclear response regulator and transcription factor, part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation"
>YHR207C SET5 SGDID:S000001250, Chr VIII from 516485-514905, reverse complement, Verified ORF, "Zinc-finger protein of unknown function, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus"
>YHR208W BAT1 SGDID:S000001251, Chr VIII from 517532-518713, Verified ORF, "Mitochondrial branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase"
>YHR209W CRG1 SGDID:S000001252, Chr VIII from 519437-520312, Uncharacterized ORF, "mRNA binding protein and putative S-adenosylmethionine-dependent methyltransferase; mediates cantharidin resistance"
>YHR210C YHR210C SGDID:S000001253, Chr VIII from 521737-520712, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; non-essential gene; highly expressed under anaeorbic conditions; sequence similarity to aldose 1-epimerases such as GAL10"
>YHR211W FLO5 SGDID:S000001254, Chr VIII from 525392-528619, Verified ORF, "Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p"
>YHR212C YHR212C SGDID:S000001255, Chr VIII from 538094-537759, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YHR212W-A YHR212W-A SGDID:S000028650, Chr VIII from 538742-538945, Uncharacterized ORF, "Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YHR213W YHR213W SGDID:S000001256, Chr VIII from 539151-539747, Uncharacterized ORF, "Possible pseudogene; has similarity to Flo1p, which is a lectin-like protein involved in flocculation"
>YHR213W-A YHR213W-A SGDID:S000028651, Chr VIII from 540549-540782, Uncharacterized ORF, "Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YHR213W-B YHR213W-B SGDID:S000028652, Chr VIII from 540800-541099, Uncharacterized ORF, "Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YHR214C-B YHR214C-B SGDID:S000003534, Chr VIII from 547929-543964,549346-547931, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YHR214C-C YHR214C-C SGDID:S000007421, Chr VIII from 549346-547910, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YHR214C-D YHR214C-D SGDID:S000028653, Chr VIII from 550941-550648, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YHR214C-E YHR214C-E SGDID:S000028654, Chr VIII from 551499-551200, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YHR214W YHR214W SGDID:S000001257, Chr VIII from 541651-542262, Uncharacterized ORF, "Putative protein of unknown function; predicted to be a glycosylphosphatidylinositol-modified (GPI) protein"
>YHR214W-A YHR214W-A SGDID:S000003535, Chr VIII from 543008-543493, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; similar to the fungal specific protein encoded by YAR068W; induced by zinc deficiency"
>YHR215W PHO12 SGDID:S000001258, Chr VIII from 552099-553502, Verified ORF, "One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; nearly identical to Pho11p; upregulated by phosphate starvation"
>YHR216W IMD2 SGDID:S000001259, Chr VIII from 554396-555967, Verified ORF, "Inosine monophosphate dehydrogenase, catalyzes the rate-limiting step in GTP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitatio"
>YHR217C YHR217C SGDID:S000001260, Chr VIII from 557042-556581, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; located in the telomeric region TEL08R."
>YHR218W YHR218W SGDID:S000001261, Chr VIII from 558014-558615,558715-559924, Uncharacterized ORF, "Helicase-like protein encoded within the telomeric Y' element"
>YHR218W-A YHR218W-A SGDID:S000028786, Chr VIII from 559932-560249, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YHR219C-A YHR219C-A SGDID:S000028655, Chr VIII from 561681-561199, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YHR219W YHR219W SGDID:S000001262, Chr VIII from 560173-562047, Uncharacterized ORF, "Putative protein of unknown function with similarity to helicases; located in the telomere region on the right arm of chromosome VIII"
>YIL001W YIL001W SGDID:S000001263, Chr IX from 353940-355481, Uncharacterized ORF, "Putative protein of unknown function; contains a BTB/POZ domain which generally function in protein interactions; deletion slightly improved competitive fitness in rich media; GFP-tagged protein is localized to the cytoplasm"
>YIL002C INP51 SGDID:S000001264, Chr IX from 353431-350591, reverse complement, Verified ORF, "Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth"
>YIL002W-A YIL002W-A SGDID:S000028835, Chr IX from 350301-350510, Uncharacterized ORF, "Putative protein of unknown function; identified by expression profiling and mass spectrometry"
>YIL003W CFD1 SGDID:S000001265, Chr IX from 349122-350003, Verified ORF, "Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol"
>YIL004C BET1 SGDID:S000001266, Chr IX from 348363-347946,348505-348495, reverse complement, Verified ORF, "Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins"
>YIL005W EPS1 SGDID:S000001267, Chr IX from 345692-347797, Verified ORF, "ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family"
>YIL006W YIA6 SGDID:S000001268, Chr IX from 344062-345183, Verified ORF, "Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs"
>YIL007C NAS2 SGDID:S000001269, Chr IX from 343656-342994, reverse complement, Verified ORF, "Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p"
>YIL008W URM1 SGDID:S000001270, Chr IX from 342536-342835, Verified ORF, "Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response"
>YIL009C-A EST3 SGDID:S000006432, Chr IX from 335935-335666,336212-335937, reverse complement, Verified ORF, "Component of the telomerase holoenzyme, involved in telomere replication"
>YIL009W FAA3 SGDID:S000001271, Chr IX from 339344-341428, Verified ORF, "Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery"
>YIL010W DOT5 SGDID:S000001272, Chr IX from 334882-335529, Verified ORF, "Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth"
>YIL011W TIR3 SGDID:S000001273, Chr IX from 333727-334536, Verified ORF, "Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth"
>YIL012W YIL012W SGDID:S000001274, Chr IX from 333011-333352, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YIL013C PDR11 SGDID:S000001275, Chr IX from 332442-328207, reverse complement, Verified ORF, "ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromisedregulated by Pdr1p; required for anaerobic growth"
>YIL014C-A YIL014C-A SGDID:S000003536, Chr IX from 325526-325212, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YIL014W MNT3 SGDID:S000001276, Chr IX from 326103-327995, Verified ORF, "Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation"
>YIL015W BAR1 SGDID:S000001277, Chr IX from 322342-324105, Verified ORF, "Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest"
>YIL016W SNL1 SGDID:S000001278, Chr IX from 321454-321933, Verified ORF, "Protein of unknown function proposed to be involved in nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein"
>YIL017C VID28 SGDID:S000001279, Chr IX from 320965-318200, reverse complement, Verified ORF, "Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm"
>YIL018W RPL2B SGDID:S000001280, Chr IX from 316768-316771,317172-317932, Verified ORF, "Protein component of the large (60S) ribosomal subunit, identical to Rpl2Ap and has similarity to E. coli L2 and rat L8 ribosomal proteins; expression is upregulated at low temperatures"
>YIL019W FAF1 SGDID:S000001281, Chr IX from 315093-316133, Verified ORF, "Protein required for pre-rRNA processing and 40S ribosomal subunit assembly"
>YIL020C HIS6 SGDID:S000001282, Chr IX from 314820-314035, reverse complement, Verified ORF, "Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts"
>YIL020C-A YIL020C-A SGDID:S000028787, Chr IX from 314051-313713, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YIL021C-A YIL021C-A SGDID:S000028656, Chr IX from 313468-313199, reverse complement, Dubious ORF, "Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene RPB3/YIL021W; identified by gene-trapping, expression analysis, and genome-wide homology searching"
>YIL021W RPB3 SGDID:S000001283, Chr IX from 312905-313861, Verified ORF, "RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit"
>YIL022W TIM44 SGDID:S000001284, Chr IX from 311165-312460, Verified ORF, "Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)"
>YIL023C YKE4 SGDID:S000001285, Chr IX from 310426-309386, reverse complement, Verified ORF, "Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family"
>YIL024C YIL024C SGDID:S000001286, Chr IX from 309171-308602, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p"
>YIL025C YIL025C SGDID:S000001287, Chr IX from 308575-308201, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YIL026C IRR1 SGDID:S000001288, Chr IX from 307929-304477, reverse complement, Verified ORF, "Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability"
>YIL027C KRE27 SGDID:S000001289, Chr IX from 304104-303679, reverse complement, Verified ORF, "Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance"
>YIL028W YIL028W SGDID:S000001290, Chr IX from 302100-302498, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YIL029C YIL029C SGDID:S000001291, Chr IX from 301257-300829, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)"
>YIL029W-A YIL029W-A SGDID:S000028788, Chr IX from 299735-300106, Dubious ORF, "Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YIL030C SSM4 SGDID:S000001292, Chr IX from 300009-296050, reverse complement, Verified ORF, "Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation"
>YIL030W-A YIL030W-A SGDID:S000028789, Chr IX from 295565-295903, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIL031W."
>YIL031W ULP2 SGDID:S000001293, Chr IX from 292633-295737, Verified ORF, "Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate"
>YIL032C YIL032C SGDID:S000001294, Chr IX from 292317-291961, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YIL033C BCY1 SGDID:S000001295, Chr IX from 291669-290419, reverse complement, Verified ORF, "Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation"
>YIL034C CAP2 SGDID:S000001296, Chr IX from 290089-289226, reverse complement, Verified ORF, "Beta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches"
>YIL035C CKA1 SGDID:S000001297, Chr IX from 288908-287790, reverse complement, Verified ORF, "Alpha catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA2, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases"
>YIL036W CST6 SGDID:S000001298, Chr IX from 285666-287429, Verified ORF, "Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability"
>YIL037C PRM2 SGDID:S000001299, Chr IX from 284999-283029, reverse complement, Verified ORF, "Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p; required for efficient nuclear fusion"
>YIL038C NOT3 SGDID:S000001300, Chr IX from 282652-280142, reverse complement, Verified ORF, "Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation"
>YIL039W TED1 SGDID:S000001301, Chr IX from 278426-279847, Uncharacterized ORF, "Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)"
>YIL040W APQ12 SGDID:S000001302, Chr IX from 277723-278139, Verified ORF, "Protein required for nuclear envelope morphology, nuclear pore complex localization, mRNA export from the nucleus; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism"
>YIL041W GVP36 SGDID:S000001303, Chr IX from 276525-277505, Verified ORF, "BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis"
>YIL042C PKP1 SGDID:S000001304, Chr IX from 276292-275108, reverse complement, Verified ORF, "Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p"
>YIL043C CBR1 SGDID:S000001305, Chr IX from 274926-274072, reverse complement, Verified ORF, "Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia"
>YIL044C AGE2 SGDID:S000001306, Chr IX from 273846-272950, reverse complement, Verified ORF, "ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif"
>YIL045W PIG2 SGDID:S000001307, Chr IX from 271161-272777, Verified ORF, "Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase"
>YIL046W MET30 SGDID:S000001308, Chr IX from 268651-270573, Verified ORF, "F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus"
>YIL046W-A YIL046W-A SGDID:S000028836, Chr IX from 268309-268473, Uncharacterized ORF, "Putative protein of unknown function; identified by expression profiling and mass spectrometry"
>YIL047C SYG1 SGDID:S000001309, Chr IX from 267823-265115, reverse complement, Verified ORF, "Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency"
>YIL047C-A YIL047C-A SGDID:S000028790, Chr IX from 265467-265099, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YIL048W NEO1 SGDID:S000001310, Chr IX from 261437-264892, Verified ORF, "Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus"
>YIL049W DFG10 SGDID:S000001311, Chr IX from 260158-260919, Verified ORF, "Protein of unknown function, involved in filamentous growth"
>YIL050W PCL7 SGDID:S000001312, Chr IX from 258913-259770, Verified ORF, "Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated"
>YIL051C MMF1 SGDID:S000001313, Chr IX from 258280-257843, reverse complement, Verified ORF, "Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes"
>YIL052C RPL34B SGDID:S000001314, Chr IX from 256554-256226,257063-257027, reverse complement, Verified ORF, "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein"
>YIL053W RHR2 SGDID:S000001315, Chr IX from 255115-255867, Verified ORF, "Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress"
>YIL054W YIL054W SGDID:S000001316, Chr IX from 254543-254860, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YIL055C YIL055C SGDID:S000001317, Chr IX from 253925-252042, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YIL056W VHR1 SGDID:S000001318, Chr IX from 249991-251913, Verified ORF, "Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations"
>YIL057C RGI2 SGDID:S000001319, Chr IX from 248396-247902, reverse complement, Verified ORF, "Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose"
>YIL058W YIL058W SGDID:S000001320, Chr IX from 246914-247198, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YIL059C YIL059C SGDID:S000001321, Chr IX from 246915-246550, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W"
>YIL060W YIL060W SGDID:S000001322, Chr IX from 246392-246826, Uncharacterized ORF, "Putative protein of unknown function; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene"
>YIL061C SNP1 SGDID:S000001323, Chr IX from 245559-244657, reverse complement, Verified ORF, "Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein"
>YIL062C ARC15 SGDID:S000001324, Chr IX from 244462-243998, reverse complement, Verified ORF, "Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; has mRNA binding activity"
>YIL063C YRB2 SGDID:S000001325, Chr IX from 243744-242761, reverse complement, Verified ORF, "Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential"
>YIL064W SEE1 SGDID:S000001326, Chr IX from 241943-242716, Verified ORF, "Probable lysine methyltransferase involved in the dimethylation of eEF1A (Tef1p/Tef2p); sequence similarity to S-adenosylmethionine-dependent methyltransferases of the seven beta-strand family; role in vesicular transport"
>YIL065C FIS1 SGDID:S000001327, Chr IX from 241775-241308, reverse complement, Verified ORF, "Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation"
>YIL066C RNR3 SGDID:S000001328, Chr IX from 240708-238099, reverse complement, Verified ORF, "Minor isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits"
>YIL066W-A YIL066W-A SGDID:S000028791, Chr IX from 237366-237809, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YIL067C YIL067C SGDID:S000001329, Chr IX from 237760-235724, reverse complement, Uncharacterized ORF, "Uncharacterized protein of unknown function"
>YIL068C SEC6 SGDID:S000001330, Chr IX from 235474-233057, reverse complement, Verified ORF, "Essential 88kDa subunit of the exocyst complex, which mediates polarized targeting of secretory vesicles to active sites of exocytosis; dimeric form of Sec6p interacts with Sec9p in vitro and inhibits t-SNARE assembly"
>YIL068W-A YIL068W-A SGDID:S000028792, Chr IX from 233013-233396, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YIL069C RPS24B SGDID:S000001331, Chr IX from 231957-231553,232369-232367, reverse complement, Verified ORF, "Protein component of the small (40S) ribosomal subunit; identical to Rps24Ap and has similarity to rat S24 ribosomal protein"
>YIL070C MAM33 SGDID:S000001332, Chr IX from 231072-230272, reverse complement, Verified ORF, "Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R"
>YIL071C PCI8 SGDID:S000001333, Chr IX from 229994-228660, reverse complement, Verified ORF, "Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain"
>YIL071W-A YIL071W-A SGDID:S000028793, Chr IX from 228550-229026, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YIL072W HOP1 SGDID:S000001334, Chr IX from 226602-228419, Verified ORF, "Meiosis-specific DNA binding protein that displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for homologous chromosome synapsis and chiasma formation"
>YIL073C SPO22 SGDID:S000001335, Chr IX from 225809-222937,225954-225900, reverse complement, Verified ORF, "Meiosis-specific protein essential for chromosome synapsis, involved in completion of nuclear divisions during meiosis; induced early in meiosis"
>YIL074C SER33 SGDID:S000001336, Chr IX from 222490-221081, reverse complement, Verified ORF, "3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser3p"
>YIL075C RPN2 SGDID:S000001337, Chr IX from 220700-217863, reverse complement, Verified ORF, "Subunit of the 26S proteasome, substrate of the N-acetyltransferase Nat1p"
>YIL076W SEC28 SGDID:S000001338, Chr IX from 216658-217548, Verified ORF, "Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth"
>YIL077C YIL077C SGDID:S000001339, Chr IX from 215953-214991, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)"
>YIL078W THS1 SGDID:S000001340, Chr IX from 212499-214703, Verified ORF, "Threonyl-tRNA synthetase, essential cytoplasmic protein"
>YIL079C AIR1 SGDID:S000001341, Chr IX from 212005-210923, reverse complement, Verified ORF, "Zinc knuckle protein, involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; functionally redundant with Air2p"
>YIL080W YIL080W SGDID:S000001342, Chr IX from 205635-206484,206486-210357, pseudogene, "TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition"
>YIL082W YIL082W SGDID:S000001344, Chr IX from 205635-206507, Dubious ORF, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YIL082W-A YIL082W-A SGDID:S000003537, Chr IX from 205635-206485,206487-210132, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YIL083C CAB2 SGDID:S000001345, Chr IX from 204653-203556, reverse complement, Verified ORF, "Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)"
>YIL084C SDS3 SGDID:S000001346, Chr IX from 203259-202276, reverse complement, Verified ORF, "Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes"
>YIL085C KTR7 SGDID:S000001347, Chr IX from 202043-200490, reverse complement, Verified ORF, "Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family"
>YIL086C YIL086C SGDID:S000001348, Chr IX from 200461-200153, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YIL087C AIM19 SGDID:S000001349, Chr IX from 200119-199646, reverse complement, Verified ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth"
>YIL088C AVT7 SGDID:S000001350, Chr IX from 199403-197931, reverse complement, Verified ORF, "Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters"
>YIL089W YIL089W SGDID:S000001351, Chr IX from 195599-196216, Uncharacterized ORF, "Putative protein of unknown function"
>YIL090W ICE2 SGDID:S000001352, Chr IX from 193595-195070, Verified ORF, "Integral ER membrane protein with type-III transmembrane domains; mutations cause defects in cortical ER morphology in both the mother and daughter cells"
>YIL091C UTP25 SGDID:S000001353, Chr IX from 193195-191030, reverse complement, Verified ORF, "Nucleolar protein required for 35S pre-RNA processing and 40S ribosomal subunit biogenesis; contains a DEAD-box RNA helicase-like motif"
>YIL092W YIL092W SGDID:S000001354, Chr IX from 189066-190967, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus"
>YIL093C RSM25 SGDID:S000001355, Chr IX from 188784-187990, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the small subunit"
>YIL094C LYS12 SGDID:S000001356, Chr IX from 187632-186517, reverse complement, Verified ORF, "Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate"
>YIL095W PRK1 SGDID:S000001357, Chr IX from 183937-186369, Verified ORF, "Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton and reduces endocytic ability of cell through the phosphorylation of the Pan1p-Sla1p-End3p protein complex"
>YIL096C YIL096C SGDID:S000001358, Chr IX from 183127-182117, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; associates with precursors of the 60S ribosomal subunit; predicted to be involved in ribosome biogenesis"
>YIL097W FYV10 SGDID:S000001359, Chr IX from 180427-181977, Verified ORF, "Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in proteasome-dependent catabolite inactivation of FBPase; contains CTLH domain; plays role in anti-apoptosis"
>YIL098C FMC1 SGDID:S000001360, Chr IX from 180239-179772, reverse complement, Verified ORF, "Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p"
>YIL099W SGA1 SGDID:S000001361, Chr IX from 178004-179653, Verified ORF, "Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation"
>YIL100C-A YIL100C-A SGDID:S000028794, Chr IX from 177681-177343, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YIL100W YIL100W SGDID:S000001362, Chr IX from 177373-177726, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A"
>YIL101C XBP1 SGDID:S000001363, Chr IX from 177250-175307, reverse complement, Verified ORF, "Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate"
>YIL102C YIL102C SGDID:S000001364, Chr IX from 174887-174582, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YIL102C-A YIL102C-A SGDID:S000113587, Chr IX from 173592-173365, reverse complement, Uncharacterized ORF, "Putative protein of unknown function, identified based on comparisons of the genome sequences of six Saccharomyces species"
>YIL103W DPH1 SGDID:S000001365, Chr IX from 171751-173028, Verified ORF, "Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p"
>YIL104C SHQ1 SGDID:S000001366, Chr IX from 171505-169982, reverse complement, Verified ORF, "Chaperone protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones"
>YIL105C SLM1 SGDID:S000001367, Chr IX from 169641-167581, reverse complement, Verified ORF, "Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex"
>YIL105W-A YIL105W-A SGDID:S000028657, Chr IX from 167664-167804, Dubious ORF, "Dubious open reading frame; completely overlaps the verified gene SLM1; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YIL106W MOB1 SGDID:S000001368, Chr IX from 166415-166434,166520-167444, Verified ORF, "Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex"
>YIL107C PFK26 SGDID:S000001369, Chr IX from 165761-163278, reverse complement, Verified ORF, "6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A"
>YIL108W YIL108W SGDID:S000001370, Chr IX from 160887-162977, Uncharacterized ORF, "Putative metalloprotease"
>YIL109C SEC24 SGDID:S000001371, Chr IX from 160165-157385, reverse complement, Verified ORF, "Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb2p and Sfb3p"
>YIL110W HPM1 SGDID:S000001372, Chr IX from 156045-157178, Verified ORF, "AdoMet-dependent methyltransferase involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance"
>YIL111W COX5B SGDID:S000001373, Chr IX from 155222-155222,155311-155765, Verified ORF, "Subunit Vb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth"
>YIL112W HOS4 SGDID:S000001374, Chr IX from 151595-154846, Verified ORF, "Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate"
>YIL113W SDP1 SGDID:S000001375, Chr IX from 150559-151188, Verified ORF, "Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock"
>YIL114C POR2 SGDID:S000001376, Chr IX from 149988-149143, reverse complement, Verified ORF, "Putative mitochondrial porin (voltage-dependent anion channel), related to Por1p but not required for mitochondrial membrane permeability or mitochondrial osmotic stability"
>YIL115C NUP159 SGDID:S000001377, Chr IX from 148709-144327, reverse complement, Verified ORF, "Nucleoporin, subunit of the nuclear pore complex that is found exclusively on the cytoplasmic side, member of the Nup82 subcomplex, required for mRNA export"
>YIL115W-A YIL115W-A SGDID:S000028795, Chr IX from 144268-144639, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene NUP159/YIL115C"
>YIL116W HIS5 SGDID:S000001378, Chr IX from 142928-144085, Verified ORF, "Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts"
>YIL117C PRM5 SGDID:S000001379, Chr IX from 141569-140613, reverse complement, Verified ORF, "Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling"
>YIL118W RHO3 SGDID:S000001380, Chr IX from 139752-140447, Verified ORF, "Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p"
>YIL119C RPI1 SGDID:S000001381, Chr IX from 137877-136654, reverse complement, Verified ORF, "Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation"
>YIL120W QDR1 SGDID:S000001382, Chr IX from 134417-136108, Verified ORF, "Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, ketoconazole, fluconazole, and barban"
>YIL121W QDR2 SGDID:S000001383, Chr IX from 132244-133872, Verified ORF, "Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin; may have a role in potassium uptake"
>YIL122W POG1 SGDID:S000001384, Chr IX from 130610-131665, Verified ORF, "Putative transcriptional activator that promotes recovery from pheromone induced arrest; inhibits both alpha-factor induced G1 arrest and repression of CLN1 and CLN2 via SCB/MCB promoter elements; potential Cdc28p substrate; SBF regulated"
>YIL123W SIM1 SGDID:S000001385, Chr IX from 128151-129581, Verified ORF, "Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated"
>YIL124W AYR1 SGDID:S000001386, Chr IX from 126204-127097, Verified ORF, "NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones"
>YIL125W KGD1 SGDID:S000001387, Chr IX from 122689-125733, Verified ORF, "Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA"
>YIL126W STH1 SGDID:S000001388, Chr IX from 117992-122071, Verified ORF, "ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p"
>YIL127C RRT14 SGDID:S000001389, Chr IX from 117644-117024, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis"
>YIL128W MET18 SGDID:S000001390, Chr IX from 113806-116904, Verified ORF, "DNA repair and TFIIH regulator, required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription; involved in telomere maintenance"
>YIL129C TAO3 SGDID:S000001391, Chr IX from 113237-106107, reverse complement, Verified ORF, "Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p"
>YIL130W ASG1 SGDID:S000001392, Chr IX from 102782-105676, Verified ORF, "Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance"
>YIL131C FKH1 SGDID:S000001393, Chr IX from 102235-100781, reverse complement, Verified ORF, "Forkhead family transcription factor with a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; regulates donor preference during switching"
>YIL132C CSM2 SGDID:S000001394, Chr IX from 100501-99860, reverse complement, Verified ORF, "Protein involved in a Rad51p-, Rad54p-dependent pathway for homologous recombination repair, required for accurate chromosome segregation during meiosis"
>YIL133C RPL16A SGDID:S000001395, Chr IX from 99095-98527,99416-99386, reverse complement, Verified ORF, "N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p"
>YIL134C-A YIL134C-A SGDID:S000028556, Chr IX from 96725-96522, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by fungal homology and RT-PCR"
>YIL134W FLX1 SGDID:S000001396, Chr IX from 97395-98330, Verified ORF, "Protein required for transport of flavin adenine dinucleotide (FAD), a synthesis product of riboflavin, across the mitochondrial membrane"
>YIL135C VHS2 SGDID:S000001397, Chr IX from 96375-95065, reverse complement, Verified ORF, "Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p"
>YIL136W OM45 SGDID:S000001398, Chr IX from 93619-94800, Verified ORF, "Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane"
>YIL137C TMA108 SGDID:S000001399, Chr IX from 92788-89948, reverse complement, Verified ORF, "Protein that associates with ribosomes and is involved in ribosome biogenesis; putative metalloprotease"
>YIL138C TPM2 SGDID:S000001400, Chr IX from 89715-89230, reverse complement, Verified ORF, "Minor isoform of tropomyosin, binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p"
>YIL139C REV7 SGDID:S000001401, Chr IX from 88716-87979, reverse complement, Verified ORF, "Accessory subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair"
>YIL140W AXL2 SGDID:S000001402, Chr IX from 85366-87837, Verified ORF, "Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate"
>YIL141W YIL141W SGDID:S000001403, Chr IX from 85053-85442, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YIL142C-A YIL142C-A SGDID:S000028796, Chr IX from 83540-83208, reverse complement, Dubious ORF, "Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YIL142W CCT2 SGDID:S000001404, Chr IX from 83302-84885, Verified ORF, "Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo"
>YIL143C SSL2 SGDID:S000001405, Chr IX from 83041-80510, reverse complement, Verified ORF, "Component of the holoenzyme form of RNA polymerase transcription factor TFIIH, has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; involved in DNA repair; homolog of human ERCC3"
>YIL144W TID3 SGDID:S000001406, Chr IX from 78074-80149, Verified ORF, "Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering"
>YIL145C PAN6 SGDID:S000001407, Chr IX from 77283-76354, reverse complement, Verified ORF, "Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC"
>YIL146C ATG32 SGDID:S000001408, Chr IX from 75773-74184, reverse complement, Verified ORF, "Mitochondrial-anchored transmembrane receptor that interacts with the autophagy adaptor protein, Atg11p, and is essential for mitophagy, the selective vacuolar degradation of mitochondria in response to starvation"
>YIL147C SLN1 SGDID:S000001409, Chr IX from 73453-69791, reverse complement, Verified ORF, "Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators"
>YIL148W RPL40A SGDID:S000001410, Chr IX from 68708-68715,69150-69528, Verified ORF, "Fusion protein, identical to Rpl40Bp, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes"
>YIL149C MLP2 SGDID:S000001411, Chr IX from 68067-63028, reverse complement, Verified ORF, "Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length"
>YIL150C MCM10 SGDID:S000001412, Chr IX from 62728-61013, reverse complement, Verified ORF, "Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins"
>YIL151C YIL151C SGDID:S000001413, Chr IX from 60694-57338, reverse complement, Uncharacterized ORF, "Putative protein of unknown function, predicted to contain a PINc domain"
>YIL152W YIL152W SGDID:S000001414, Chr IX from 56545-57252, Uncharacterized ORF, "Putative protein of unknown function"
>YIL153W RRD1 SGDID:S000001415, Chr IX from 55198-56379, Verified ORF, "Peptidyl-prolyl cis/trans-isomerase, activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; subunit of the Tap42p-Sit4p-Rrd1p complex"
>YIL154C IMP2' SGDID:S000001416, Chr IX from 55021-53981, reverse complement, Verified ORF, "Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat"
>YIL155C GUT2 SGDID:S000001417, Chr IX from 53708-51759, reverse complement, Verified ORF, "Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner"
>YIL156W UBP7 SGDID:S000001418, Chr IX from 48091-51306, Verified ORF, "Ubiquitin-specific protease that cleaves ubiquitin-protein fusions"
>YIL156W-A YIL156W-A SGDID:S000028797, Chr IX from 47292-47693, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YIL156W-B YIL156W-B SGDID:S000028511, Chr IX from 47690-47698,47761-47973, Uncharacterized ORF, "Putative protein of unknown function, originally identified based on homology to <i>Ashbya gossypii</i> and other related yeasts"
>YIL157C COA1 SGDID:S000001419, Chr IX from 47542-46949, reverse complement, Verified ORF, "Mitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly"
>YIL158W AIM20 SGDID:S000001420, Chr IX from 46201-46815, Verified ORF, "Putative protein of unknown function; overexpression causes a cell cycle delay or arrest; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; null mutant displays elevated frequency of mitochondrial genome loss"
>YIL159W BNR1 SGDID:S000001421, Chr IX from 41825-45952, Verified ORF, "Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1"
>YIL160C POT1 SGDID:S000001422, Chr IX from 41444-40191, reverse complement, Verified ORF, "3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids"
>YIL161W YIL161W SGDID:S000001423, Chr IX from 39433-40140, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene"
>YIL162W SUC2 SGDID:S000001424, Chr IX from 37385-38983, Verified ORF, "Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively"
>YIL163C YIL163C SGDID:S000001425, Chr IX from 37252-36899, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YIL164C NIT1 SGDID:S000001426, Chr IX from 34686-34087, reverse complement, Verified ORF, "Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene"
>YIL165C YIL165C SGDID:S000001427, Chr IX from 34077-33718, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; mutant exhibits mitophagy defects; in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF, YIL164C, likely constitute a single ORF encoding a nitrilase gene"
>YIL166C YIL166C SGDID:S000001428, Chr IX from 32566-30938, reverse complement, Uncharacterized ORF, "Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene"
>YIL167W SDL1 SGDID:S000001429, Chr IX from 29416-30048, pseudogene, "Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other <i>S. cerevisiae</i> strain backgrounds YIL167W and adjacent ORF, YIL168W, constitute a single ORF encoding L-serine dehydratase"
>YIL168W YIL168W SGDID:S000001430, Chr IX from 29032-29415, pseudogene, "Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other <i>S. cerevisiae</i> strain backgrounds YIL168W and adjacent ORF, YIL167W, constitute a single ORF encoding L-serine dehydratase"
>YIL169C YIL169C SGDID:S000001431, Chr IX from 26106-23119, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene"
>YIL170W HXT12 SGDID:S000001432, Chr IX from 19847-21220, pseudogene, "Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family"
>YIL171W YIL171W SGDID:S000001433, Chr IX from 19515-19844, pseudogene, "Possible pseudogene in strain S288C; YIL171W and the adjacent ORF, YIL170W/HXT12, together encode a non-functional member of the hexose transporter family"
>YIL171W-A YIL171W-A SGDID:S000028798, Chr IX from 18260-18712, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YIL172C IMA3 SGDID:S000001434, Chr IX from 18553-16784, reverse complement, Verified ORF, "Alpha-glucosidase with broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides; member of IMA isomaltase family; not required for isomaltose utilization, but Ima3p overexpression allows the ima1 null mutant to grow on isomaltose"
>YIL173W VTH1 SGDID:S000001435, Chr IX from 11492-16141, Verified ORF, "Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting"
>YIL174W YIL174W SGDID:S000001436, Chr IX from 9469-9696, pseudogene, "Hypothetical protein"
>YIL175W YIL175W SGDID:S000001437, Chr IX from 9183-9500, pseudogene, "Hypothetical protein"
>YIL176C PAU14 SGDID:S000001438, Chr IX from 9155-8793, reverse complement, Uncharacterized ORF, "Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau1p"
>YIL177C YIL177C SGDID:S000001439, Chr IX from 4598-483,6147-4987, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; similarity to DNA helicases that are encoded within subtelomeric Y' elements and induced in telomerase deficient survivors"
>YIL177W-A YIL177W-A SGDID:S000028658, Chr IX from 846-1328, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene YIL177C"
>YIR001C SGN1 SGDID:S000001440, Chr IX from 356895-356143, reverse complement, Verified ORF, "Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation"
>YIR002C MPH1 SGDID:S000001441, Chr IX from 360396-357415, reverse complement, Verified ORF, "Member of the DEAH family of helicases, functions in an error-free DNA damage bypass pathway that involves homologous recombination, binds to flap DNA and stimulates activity of Rad27p and Dna2p; mutations confer a mutator phenotype"
>YIR003W AIM21 SGDID:S000001442, Chr IX from 360885-362924, Verified ORF, "Protein of unknown function involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton"
>YIR004W DJP1 SGDID:S000001443, Chr IX from 363221-364519, Verified ORF, "Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ"
>YIR005W IST3 SGDID:S000001444, Chr IX from 364889-365335, Verified ORF, "Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing"
>YIR006C PAN1 SGDID:S000001445, Chr IX from 369908-365466, reverse complement, Verified ORF, "Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; previously thought to be a subunit of poly(A) ribonuclease"
>YIR007W YIR007W SGDID:S000001446, Chr IX from 370704-372998, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene"
>YIR008C PRI1 SGDID:S000001447, Chr IX from 374306-373077, reverse complement, Verified ORF, "Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair"
>YIR009W MSL1 SGDID:S000001448, Chr IX from 374525-374860, Verified ORF, "U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members"
>YIR010W DSN1 SGDID:S000001449, Chr IX from 375431-377161, Verified ORF, "Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation"
>YIR011C STS1 SGDID:S000001450, Chr IX from 378246-377287, reverse complement, Verified ORF, "Protein that interacts with the karyopherin Srp1p; may have a role with Srp1p in ubiquitin-mediated protein degradation"
>YIR012W SQT1 SGDID:S000001451, Chr IX from 378486-379781, Verified ORF, "Essential protein involved in a late step of 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay"
>YIR013C GAT4 SGDID:S000001452, Chr IX from 380384-380019, reverse complement, Verified ORF, "Protein containing GATA family zinc finger motifs"
>YIR014W YIR014W SGDID:S000001453, Chr IX from 381086-381814, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene"
>YIR015W RPR2 SGDID:S000001454, Chr IX from 381948-382382, Verified ORF, "Subunit of nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits"
>YIR016W YIR016W SGDID:S000001455, Chr IX from 382628-383425, Uncharacterized ORF, "Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; YIR016W is a non-essential gene"
>YIR017C MET28 SGDID:S000001456, Chr IX from 384119-383556, reverse complement, Verified ORF, "Basic leucine zipper (bZIP) transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism"
>YIR017W-A YIR017W-A SGDID:S000028799, Chr IX from 383566-384165, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YIR018C-A YIR018C-A SGDID:S000028837, Chr IX from 385701-385564, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by expression profiling and mass spectrometry"
>YIR018W YAP5 SGDID:S000001457, Chr IX from 384609-385346, Verified ORF, "Basic leucine zipper (bZIP) transcription factor"
>YIR019C MUC1 SGDID:S000001458, Chr IX from 393675-389572, reverse complement, Verified ORF, "GPI-anchored cell surface glycoprotein (flocculin) required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p)"
>YIR020C YIR020C SGDID:S000001459, Chr IX from 394557-394255, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YIR020C-B YIR020C-B SGDID:S000028800, Chr IX from 397949-397215, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF MRS1"
>YIR020W-A YIR020W-A SGDID:S000007241, Chr IX from 394917-395159, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data"
>YIR021W MRS1 SGDID:S000001460, Chr IX from 397294-398385, Verified ORF, "Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA"
>YIR021W-A YIR021W-A SGDID:S000028838, Chr IX from 398514-398726, Uncharacterized ORF, "Putative protein of unknown function; identified by expression profiling and mass spectrometry"
>YIR022W SEC11 SGDID:S000001461, Chr IX from 398733-399236, Verified ORF, "18kDa catalytic subunit of the Signal Peptidase Complex (SPC; Spc1p, Spc2p, Spc3p, and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum"
>YIR023C-A YIR023C-A SGDID:S000028801, Chr IX from 402706-402383, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YIR023W DAL81 SGDID:S000001462, Chr IX from 399777-402689, Verified ORF, "Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism"
>YIR024C YIR024C SGDID:S000001463, Chr IX from 403491-402841, reverse complement, Verified ORF, "Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect"
>YIR025W MND2 SGDID:S000001464, Chr IX from 403659-404765, Verified ORF, "Subunit of the anaphase-promoting complex (APC); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase"
>YIR026C YVH1 SGDID:S000001465, Chr IX from 405967-404873, reverse complement, Verified ORF, "Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases"
>YIR027C DAL1 SGDID:S000001466, Chr IX from 407642-406260, reverse complement, Verified ORF, "Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression"
>YIR028W DAL4 SGDID:S000001467, Chr IX from 408468-410375, Verified ORF, "Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation"
>YIR029W DAL2 SGDID:S000001468, Chr IX from 410807-411838, Verified ORF, "Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation"
>YIR030C DCG1 SGDID:S000001469, Chr IX from 412770-412036, reverse complement, Verified ORF, "Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain"
>YIR030W-A YIR030W-A SGDID:S000028802, Chr IX from 412899-413282, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YIR031C DAL7 SGDID:S000001470, Chr IX from 414679-413015, reverse complement, Verified ORF, "Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation"
>YIR032C DAL3 SGDID:S000001471, Chr IX from 415617-415030, reverse complement, Verified ORF, "Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression"
>YIR033W MGA2 SGDID:S000001472, Chr IX from 416124-419465, Verified ORF, "ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting"
>YIR034C LYS1 SGDID:S000001473, Chr IX from 420736-419615, reverse complement, Verified ORF, "Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity"
>YIR035C YIR035C SGDID:S000001474, Chr IX from 421790-421026, reverse complement, Uncharacterized ORF, "Putative cytoplasmic protein of unknown function"
>YIR036C IRC24 SGDID:S000001475, Chr IX from 422865-422074, reverse complement, Uncharacterized ORF, "Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci"
>YIR036W-A YIR036W-A SGDID:S000028803, Chr IX from 422635-423036, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YIR037W HYR1 SGDID:S000001476, Chr IX from 423128-423619, Verified ORF, "Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor"
>YIR038C GTT1 SGDID:S000001477, Chr IX from 424513-423809, reverse complement, Verified ORF, "ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p"
>YIR039C YPS6 SGDID:S000001478, Chr IX from 432111-430498, reverse complement, Verified ORF, "Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance"
>YIR040C YIR040C SGDID:S000001479, Chr IX from 433721-433389, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data"
>YIR041W PAU15 SGDID:S000001480, Chr IX from 433929-434303, Verified ORF, "Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions"
>YIR042C YIR042C SGDID:S000001481, Chr IX from 435983-435273, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; YIR042C is a non-essential gene"
>YIR043C YIR043C SGDID:S000001482, Chr IX from 437735-437043, reverse complement, pseudogene, "Possible pseudogene in strain S288C; YIR043C and the adjacent ORF, YIR044C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family"
>YIR044C YIR044C SGDID:S000001483, Chr IX from 438179-437994, reverse complement, pseudogene, "Possible pseudogene in strain S288C; YIR044C and the adjacent ORF, YIR043C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family"
>YJL001W PRE3 SGDID:S000003538, Chr X from 435163-435227,435344-435926, Verified ORF, "Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides"
>YJL002C OST1 SGDID:S000003539, Chr X from 434651-433221, reverse complement, Verified ORF, "Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins"
>YJL003W COX16 SGDID:S000003540, Chr X from 432644-433000, Verified ORF, "Mitochondrial inner membrane protein, required for assembly of cytochrome c oxidase"
>YJL004C SYS1 SGDID:S000003541, Chr X from 432200-431589, reverse complement, Verified ORF, "Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation"
>YJL005W CYR1 SGDID:S000003542, Chr X from 425157-431237, Verified ORF, "Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation"
>YJL006C CTK2 SGDID:S000003543, Chr X from 424109-423138, reverse complement, Verified ORF, "Beta subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity"
>YJL007C YJL007C SGDID:S000003544, Chr X from 423012-422698, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YJL008C CCT8 SGDID:S000003545, Chr X from 421663-419957, reverse complement, Verified ORF, "Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo"
>YJL009W YJL009W SGDID:S000003546, Chr X from 419855-420181, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex"
>YJL010C NOP9 SGDID:S000003547, Chr X from 419562-417562, reverse complement, Verified ORF, "Essential subunit of U3-containing 90S preribosome involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain"
>YJL011C RPC17 SGDID:S000003548, Chr X from 414770-414285, reverse complement, Verified ORF, "RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex"
>YJL012C VTC4 SGDID:S000003549, Chr X from 413399-411234, reverse complement, Verified ORF, "Vacuolar membrane polyphosphate polymerase; subunit of the vacuolar transporter chaperone (VTC) complex involved in synthesis and transfer of polyP to the vacuole; regulates membrane trafficking; role in non-autophagic vacuolar fusion"
>YJL013C MAD3 SGDID:S000003550, Chr X from 411040-409493, reverse complement, Verified ORF, "Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover"
>YJL014W CCT3 SGDID:S000003551, Chr X from 407558-409162, Verified ORF, "Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo"
>YJL015C YJL015C SGDID:S000003552, Chr X from 407426-407142, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex, overlaps ORF YJL016W"
>YJL016W YJL016W SGDID:S000003553, Chr X from 405588-407273, Uncharacterized ORF, "Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; conserved in closely related Saccharomyces species"
>YJL019W MPS3 SGDID:S000003556, Chr X from 402897-404945, Verified ORF, "Nuclear envelope protein required for SPB duplication and nuclear fusion; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement"
>YJL020C BBC1 SGDID:S000003557, Chr X from 402410-398937, reverse complement, Verified ORF, "Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches"
>YJL020W-A YJL020W-A SGDID:S000028659, Chr X from 400981-401238, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL020C/BBC1"
>YJL022W YJL022W SGDID:S000003559, Chr X from 398109-398417, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130"
>YJL023C PET130 SGDID:S000003560, Chr X from 398398-397355, reverse complement, Verified ORF, "Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YJL024C APS3 SGDID:S000003561, Chr X from 396493-395931,396592-396571, reverse complement, Verified ORF, "Small subunit of the clathrin-associated adaptor complex AP-3, which is involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function"
>YJL025W RRN7 SGDID:S000003562, Chr X from 393967-395511, Verified ORF, "Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p"
>YJL026C-A YJL026C-A SGDID:S000028660, Chr X from 393287-393066, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL026W/RNR2"
>YJL026W RNR2 SGDID:S000003563, Chr X from 392404-393603, Verified ORF, "Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits"
>YJL027C YJL027C SGDID:S000003564, Chr X from 392249-391833, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YJL028W YJL028W SGDID:S000003565, Chr X from 391311-391646, Verified ORF, "Protein of unknown function; may interact with ribosomes, based on co-purification experiments"
>YJL029C VPS53 SGDID:S000003566, Chr X from 390853-388385, reverse complement, Verified ORF, "Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting"
>YJL030W MAD2 SGDID:S000003567, Chr X from 387657-388247, Verified ORF, "Component of the spindle-assembly checkpoint complex, which delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p"
>YJL031C BET4 SGDID:S000003568, Chr X from 387348-386368,387438-387436, reverse complement, Verified ORF, "Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p"
>YJL032W YJL032W SGDID:S000003569, Chr X from 386348-386662, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential BET4 gene encoding the alpha subunit of Type II geranylgeranyltransferase"
>YJL033W HCA4 SGDID:S000003570, Chr X from 383837-386149, Verified ORF, "Putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis"
>YJL034W KAR2 SGDID:S000003571, Chr X from 381327-383375, Verified ORF, "ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p"
>YJL035C TAD2 SGDID:S000003572, Chr X from 381001-380249, reverse complement, Verified ORF, "Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs"
>YJL036W SNX4 SGDID:S000003573, Chr X from 378825-380096, Verified ORF, "Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p"
>YJL037W IRC18 SGDID:S000003574, Chr X from 376662-377336, Verified ORF, "Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci"
>YJL038C LOH1 SGDID:S000003575, Chr X from 375774-375115, reverse complement, Verified ORF, "Protein of unknown function with proposed roles in maintenance of genome integrity and also in spore wall assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to IRC1"
>YJL039C NUP192 SGDID:S000003576, Chr X from 373799-368748, reverse complement, Verified ORF, "Essential structural subunit of the nuclear pore complex (NPC), localizes to the nuclear periphery of nuclear pores, homologous to human p205"
>YJL041W NSP1 SGDID:S000003577, Chr X from 365784-365784,365903-368373, Verified ORF, "Essential component of the nuclear pore complex, which mediates nuclear import and export, found in both the Nup82 and Nic96 complexes"
>YJL042W MHP1 SGDID:S000003578, Chr X from 361249-365445, Verified ORF, "Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins"
>YJL043W YJL043W SGDID:S000003579, Chr X from 360130-360903, Uncharacterized ORF, "Putative protein of unknown function; YJL043W is a non-essential gene"
>YJL044C GYP6 SGDID:S000003580, Chr X from 359676-358300, reverse complement, Verified ORF, "GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport"
>YJL045W YJL045W SGDID:S000003581, Chr X from 356024-357928, Verified ORF, "Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner"
>YJL046W AIM22 SGDID:S000003582, Chr X from 352386-353615, Verified ORF, "Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss"
>YJL047C RTT101 SGDID:S000003583, Chr X from 352108-349580, reverse complement, Verified ORF, "Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p"
>YJL047C-A YJL047C-A SGDID:S000028804, Chr X from 349178-349044, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YJL048C UBX6 SGDID:S000003584, Chr X from 348637-347447, reverse complement, Verified ORF, "UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline"
>YJL049W YJL049W SGDID:S000003585, Chr X from 345973-347325, Uncharacterized ORF, "Putative protein of unknown function; YJL049W is a non-essential gene"
>YJL050W MTR4 SGDID:S000003586, Chr X from 342522-345743, Verified ORF, "ATP-dependent 3'-5' RNA helicase of the Dead-box family, involved in nuclear RNA processing and degradation both as a component of the TRAMP complex and in TRAMP independent processes; has a KOW domain that shows RNA binding activity"
>YJL051W IRC8 SGDID:S000003587, Chr X from 339787-342255, Verified ORF, "Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc"
>YJL052C-A YJL052C-A SGDID:S000007610, Chr X from 338003-337884, reverse complement, Uncharacterized ORF, "Putative protein of unknown function, identified based on comparison to related yeast species"
>YJL052W TDH1 SGDID:S000003588, Chr X from 338271-339269, Verified ORF, "Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall"
>YJL053W PEP8 SGDID:S000003589, Chr X from 335898-337037, Verified ORF, "Vacuolar protein sorting protein that forms part of the multimeric membrane-associated retromer complex along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport"
>YJL054W TIM54 SGDID:S000003590, Chr X from 334265-335701, Verified ORF, "Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane"
>YJL055W YJL055W SGDID:S000003591, Chr X from 333357-334094, Uncharacterized ORF, "Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU"
>YJL056C ZAP1 SGDID:S000003592, Chr X from 333073-330431, reverse complement, Verified ORF, "Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains"
>YJL057C IKS1 SGDID:S000003593, Chr X from 330121-328118, reverse complement, Verified ORF, "Putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p"
>YJL058C BIT61 SGDID:S000003594, Chr X from 327873-326242, reverse complement, Verified ORF, "Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p-Slm1p-Slm2p), a membrane-associated complex that regulates cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity"
>YJL059W YHC3 SGDID:S000003595, Chr X from 324964-326190, Verified ORF, "Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis)"
>YJL060W BNA3 SGDID:S000003596, Chr X from 323386-324720, Verified ORF, "Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate"
>YJL061W NUP82 SGDID:S000003597, Chr X from 320016-322157, Verified ORF, "Nucleoporin, subunit of the nuclear pore complex (NPC); forms a subcomplex with Gle2p, Nup159p, Nsp1p, and Nup116p and is required for proper localization of Nup116p in the NPC"
>YJL062W LAS21 SGDID:S000003598, Chr X from 317284-319776, Verified ORF, "Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity"
>YJL062W-A COA3 SGDID:S000007611, Chr X from 316723-316980, Verified ORF, "Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly"
>YJL063C MRPL8 SGDID:S000003599, Chr X from 316475-315759, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the large subunit"
>YJL064W YJL064W SGDID:S000003600, Chr X from 315175-315570, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1"
>YJL065C DLS1 SGDID:S000003601, Chr X from 315557-315054, reverse complement, Verified ORF, "Subunit of ISW2/yCHRAC chromatin accessibility complex along with Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing"
>YJL066C MPM1 SGDID:S000003602, Chr X from 314872-314114, reverse complement, Verified ORF, "Mitochondrial membrane protein of unknown function, contains no hydrophobic stretches"
>YJL067W YJL067W SGDID:S000003603, Chr X from 314084-314434, Dubious ORF, "Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YJL068C YJL068C SGDID:S000003604, Chr X from 313915-313016, reverse complement, Verified ORF, "Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D"
>YJL069C UTP18 SGDID:S000003605, Chr X from 312706-310922, reverse complement, Verified ORF, "Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data"
>YJL070C YJL070C SGDID:S000003606, Chr X from 310637-307971, reverse complement, Uncharacterized ORF, "Putative protein of unknown function with similarity to AMP deaminases; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YJL070C is a non-essential gene"
>YJL071W ARG2 SGDID:S000003607, Chr X from 306132-307856, Verified ORF, "Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p"
>YJL072C PSF2 SGDID:S000003608, Chr X from 305862-305221, reverse complement, Verified ORF, "Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery"
>YJL073W JEM1 SGDID:S000003609, Chr X from 303181-305118, Verified ORF, "DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2"
>YJL074C SMC3 SGDID:S000003610, Chr X from 302849-299157, reverse complement, Verified ORF, "Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member"
>YJL075C APQ13 SGDID:S000003611, Chr X from 298876-298460, reverse complement, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate"
>YJL076W NET1 SGDID:S000003612, Chr X from 295245-298814, Verified ORF, "Core subunit of the RENT complex, which is a complex involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure"
>YJL077C ICS3 SGDID:S000003613, Chr X from 295061-294666, reverse complement, Verified ORF, "Protein of unknown function; may play a role in vacuolar sorting, null mutants are hypersensitive to sortin2"
>YJL077W-A YJL077W-A SGDID:S000028661, Chr X from 294799-294885, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL077C/ICS3"
>YJL077W-B YJL077W-B SGDID:S000028662, Chr X from 294047-294145, Uncharacterized ORF, "Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YJL078C PRY3 SGDID:S000003614, Chr X from 293981-291336, reverse complement, Verified ORF, "Protein of unknown function"
>YJL079C PRY1 SGDID:S000003615, Chr X from 290774-289875, reverse complement, Verified ORF, "Protein of unknown function"
>YJL080C SCP160 SGDID:S000003616, Chr X from 289226-285558, reverse complement, Verified ORF, "Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins"
>YJL081C ARP4 SGDID:S000003617, Chr X from 285271-283802, reverse complement, Verified ORF, "Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes"
>YJL082W IML2 SGDID:S000003618, Chr X from 281185-283380, Verified ORF, "Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YJL083W TAX4 SGDID:S000003619, Chr X from 278841-280655, Verified ORF, "EH domain-containing protein involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS"
>YJL084C ALY2 SGDID:S000003620, Chr X from 278002-274862, reverse complement, Verified ORF, "Protein proposed to regulate the endocytosis of plasma membrane proteins; interacts with the cyclin Pcl7p and ubiquitin ligase Rsp5p; phosphorylated by the cyclin-CDK complex, Pcl7p-Pho85p; mRNA is cell cycle regulated, peaking in M phase"
>YJL085W EXO70 SGDID:S000003621, Chr X from 272827-274698, Verified ORF, "Subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which directs secretory vesicles to active sites of exocytosis; acts with Sec3p in membrane targeting of the exocyst via PI(4,5)P2 binding"
>YJL086C YJL086C SGDID:S000003622, Chr X from 272846-272478, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1"
>YJL087C TRL1 SGDID:S000003623, Chr X from 272485-270002, reverse complement, Verified ORF, "tRNA ligase, required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR; has phosphodiesterase, polynucleotide kinase, and ligase activities; localized at the inner nuclear envelope and partially to polysomes"
>YJL088W ARG3 SGDID:S000003624, Chr X from 268799-269815, Verified ORF, "Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine"
>YJL089W SIP4 SGDID:S000003625, Chr X from 265926-268415, Verified ORF, "C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus"
>YJL090C DPB11 SGDID:S000003626, Chr X from 265051-262757, reverse complement, Verified ORF, "Replication initiation protein that loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; ortholog of human TopBP1"
>YJL091C GWT1 SGDID:S000003627, Chr X from 262552-261080, reverse complement, Verified ORF, "Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors"
>YJL092W SRS2 SGDID:S000003628, Chr X from 257423-260947, Verified ORF, "DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability"
>YJL093C TOK1 SGDID:S000003629, Chr X from 256812-254737, reverse complement, Verified ORF, "Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin"
>YJL094C KHA1 SGDID:S000003630, Chr X from 254442-251821, reverse complement, Verified ORF, "Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies"
>YJL095W BCK1 SGDID:S000003631, Chr X from 247255-251691, Verified ORF, "Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p"
>YJL096W MRPL49 SGDID:S000003632, Chr X from 246490-246975, Verified ORF, "Mitochondrial ribosomal protein of the large subunit"
>YJL097W PHS1 SGDID:S000003633, Chr X from 245591-246244, Verified ORF, "Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane, involved in elongation of very long-chain fatty acids; evolutionarily conserved, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein trafficking"
>YJL098W SAP185 SGDID:S000003634, Chr X from 242082-245258, Verified ORF, "Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p"
>YJL099W CHS6 SGDID:S000003635, Chr X from 239414-241654, Verified ORF, "Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane"
>YJL100W LSB6 SGDID:S000003636, Chr X from 237263-239086, Verified ORF, "Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization"
>YJL101C GSH1 SGDID:S000003637, Chr X from 236356-234320, reverse complement, Verified ORF, "Gamma glutamylcysteine synthetase catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury"
>YJL102W MEF2 SGDID:S000003638, Chr X from 231301-233760, Verified ORF, "Mitochondrial elongation factor involved in translational elongation"
>YJL103C GSM1 SGDID:S000003639, Chr X from 230881-229025, reverse complement, Uncharacterized ORF, "Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis"
>YJL104W PAM16 SGDID:S000003640, Chr X from 227327-227776, Verified ORF, "Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain"
>YJL105W SET4 SGDID:S000003641, Chr X from 225055-226737, Verified ORF, "Protein of unknown function, contains a SET domain"
>YJL106W IME2 SGDID:S000003642, Chr X from 221390-223327, Verified ORF, "Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p"
>YJL107C YJL107C SGDID:S000003643, Chr X from 220016-218853, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi"
>YJL108C PRM10 SGDID:S000003644, Chr X from 218856-217705, reverse complement, Verified ORF, "Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation"
>YJL109C UTP10 SGDID:S000003645, Chr X from 217309-212000, reverse complement, Verified ORF, "Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance"
>YJL110C GZF3 SGDID:S000003646, Chr X from 211577-209922, reverse complement, Verified ORF, "GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p"
>YJL111W CCT7 SGDID:S000003647, Chr X from 207877-209529, Verified ORF, "Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance"
>YJL112W MDV1 SGDID:S000003648, Chr X from 205305-207449, Verified ORF, "Peripheral protein of the cytosolic face of the mitochondrial outer membrane, required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats"
>YJL113W YJL113W SGDID:S000003649, Chr X from 198678-198998,199000-203325, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YJL114W YJL114W SGDID:S000003650, Chr X from 197915-198595, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YJL115W ASF1 SGDID:S000003651, Chr X from 196287-197126, Verified ORF, "Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition"
>YJL116C NCA3 SGDID:S000003652, Chr X from 194873-193860, reverse complement, Verified ORF, "Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family; expression induced in cells treated with the mycotoxin patulin"
>YJL117W PHO86 SGDID:S000003653, Chr X from 192531-193466, Verified ORF, "Endoplasmic reticulum (ER) resident protein required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles"
>YJL118W YJL118W SGDID:S000003654, Chr X from 191639-192298, Verified ORF, "Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL18W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein"
>YJL119C YJL119C SGDID:S000003655, Chr X from 191895-191572, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YJL120W YJL120W SGDID:S000003656, Chr X from 191022-191345, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO"
>YJL121C RPE1 SGDID:S000003657, Chr X from 191090-190374, reverse complement, Verified ORF, "D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress"
>YJL122W ALB1 SGDID:S000003658, Chr X from 189716-190243, Verified ORF, "Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p"
>YJL123C MTC1 SGDID:S000003659, Chr X from 189440-188004, reverse complement, Verified ORF, "Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1"
>YJL124C LSM1 SGDID:S000003660, Chr X from 187644-187126, reverse complement, Verified ORF, "Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs"
>YJL125C GCD14 SGDID:S000003661, Chr X from 186679-185528, reverse complement, Verified ORF, "Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression"
>YJL126W NIT2 SGDID:S000003662, Chr X from 184501-185424, Verified ORF, "Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member"
>YJL127C SPT10 SGDID:S000003663, Chr X from 184220-182298, reverse complement, Verified ORF, "Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box"
>YJL127C-B YJL127C-B SGDID:S000028522, Chr X from 181709-181551, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified based on homology to the filamentous fungus, <i>Ashbya gossypii</i>"
>YJL127W-A YJL127W-A SGDID:S000007612, Chr X from 180194-180310, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YJL128C PBS2 SGDID:S000003664, Chr X from 180103-178097, reverse complement, Verified ORF, "MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway, activated under severe osmotic stress; plays a role in regulating Ty1 transposition"
>YJL129C TRK1 SGDID:S000003665, Chr X from 177306-173599, reverse complement, Verified ORF, "Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation"
>YJL130C URA2 SGDID:S000003666, Chr X from 172367-165723, reverse complement, Verified ORF, "Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP"
>YJL131C AIM23 SGDID:S000003667, Chr X from 165348-164278, reverse complement, Verified ORF, "Putative protein of unknown function; the authentic non-tagged protein is detected in highly purified mitochondria; null mutant is viable, displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss"
>YJL132W YJL132W SGDID:S000003668, Chr X from 161914-164166, Uncharacterized ORF, "Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene"
>YJL133C-A YJL133C-A SGDID:S000028805, Chr X from 159847-159623, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YJL133W MRS3 SGDID:S000003669, Chr X from 160619-161563, Verified ORF, "Iron transporter that mediates Fe2+ transport across the inner mitochondrial membrane; mitochondrial carrier family member, similar to and functionally redundant with Mrs4p; active under low-iron conditions; may transport other cations"
>YJL134W LCB3 SGDID:S000003670, Chr X from 158188-159417, Verified ORF, "Long-chain base-1-phosphate phosphatase with specificity for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids"
>YJL135W YJL135W SGDID:S000003671, Chr X from 157877-158194, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3"
>YJL136C RPS21B SGDID:S000003672, Chr X from 156789-156550,157273-157250, reverse complement, Verified ORF, "Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Ap and has similarity to rat S21 ribosomal protein"
>YJL136W-A YJL136W-A SGDID:S000028806, Chr X from 156169-156252, Uncharacterized ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by SAGE"
>YJL137C GLG2 SGDID:S000003673, Chr X from 156127-154985, reverse complement, Verified ORF, "Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin"
>YJL138C TIF2 SGDID:S000003674, Chr X from 154691-153504, reverse complement, Verified ORF, "Translation initiation factor eIF4A, identical to Tif1p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G"
>YJL139C YUR1 SGDID:S000003675, Chr X from 152999-151713, reverse complement, Verified ORF, "Mannosyltransferase of the KTR1 family, involved in protein N-glycosylation; located in the Golgi apparatus"
>YJL140W RPB4 SGDID:S000003676, Chr X from 150961-151626, Verified ORF, "RNA polymerase II subunit B32; forms two subunit dissociable complex with Rpb7p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions"
>YJL141C YAK1 SGDID:S000003677, Chr X from 150390-147967, reverse complement, Verified ORF, "Serine-threonine protein kinase that is part of a glucose-sensing system involved in growth control in response to glucose availability; translocates from the cytoplasm to the nucleus and phosphorylates Pop2p in response to a glucose signal"
>YJL142C IRC9 SGDID:S000003678, Chr X from 148211-147819, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YJL141C; null mutant displays increased levels of spontaneous Rad52p foci"
>YJL143W TIM17 SGDID:S000003679, Chr X from 147101-147577, Verified ORF, "Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex"
>YJL144W YJL144W SGDID:S000003680, Chr X from 146359-146673, Uncharacterized ORF, "Cytoplasmic hydrophilin of unknown function, possibly involved in the dessication response; expression induced by osmotic stress, starvation and during stationary phase; GFP-fusion protein is induced by the DNA-damaging agent MMS"
>YJL145W SFH5 SGDID:S000003681, Chr X from 145160-146044, Verified ORF, "Non-classical phosphatidylinositol transfer protein (PITP); exhibits PI- but not PC-transfer activity; localizes to the peripheral endoplasmic reticulum, cytosol and microsomes; similar to Sec14p"
>YJL146W IDS2 SGDID:S000003682, Chr X from 143292-144701, Verified ORF, "Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation"
>YJL147C YJL147C SGDID:S000003683, Chr X from 142567-141419, reverse complement, Uncharacterized ORF, "Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene"
>YJL148W RPA34 SGDID:S000003684, Chr X from 140437-141138, Verified ORF, "RNA polymerase I subunit A34.5"
>YJL149W DAS1 SGDID:S000003685, Chr X from 137379-139370, Verified ORF, "Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C"
>YJL150W YJL150W SGDID:S000003686, Chr X from 137123-137425, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YJL151C SNA3 SGDID:S000003687, Chr X from 136773-136372, reverse complement, Verified ORF, "Integral membrane protein localized to vacuolar intralumenal vesicles, computational analysis of large-scale protein-protein interaction data suggests a possible role in either cell wall synthesis or protein-vacuolar targeting"
>YJL152W YJL152W SGDID:S000003688, Chr X from 136174-136533, Dubious ORF, "Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YJL153C INO1 SGDID:S000003689, Chr X from 135933-134332, reverse complement, Verified ORF, "Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element"
>YJL154C VPS35 SGDID:S000003690, Chr X from 133935-131101, reverse complement, Verified ORF, "Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval"
>YJL155C FBP26 SGDID:S000003691, Chr X from 130643-129285, reverse complement, Verified ORF, "Fructose-2,6-bisphosphatase, required for glucose metabolism"
>YJL156C SSY5 SGDID:S000003692, Chr X from 128952-126853, reverse complement, Verified ORF, "Serine protease of SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p"
>YJL156W-A YJL156W-A SGDID:S000007613, Chr X from 126604-126825, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YJL157C FAR1 SGDID:S000003693, Chr X from 126328-123836, reverse complement, Verified ORF, "Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate"
>YJL158C CIS3 SGDID:S000003694, Chr X from 122948-122265, reverse complement, Verified ORF, "Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family"
>YJL159W HSP150 SGDID:S000003695, Chr X from 120449-121690, Verified ORF, "O-mannosylated heat shock protein that is secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation"
>YJL160C YJL160C SGDID:S000003696, Chr X from 118825-117962, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis"
>YJL161W FMP33 SGDID:S000003697, Chr X from 117245-117787, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YJL162C JJJ2 SGDID:S000003698, Chr X from 115629-113878, reverse complement, Verified ORF, "Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein"
>YJL163C YJL163C SGDID:S000003699, Chr X from 113333-111666, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YJL164C TPK1 SGDID:S000003700, Chr X from 111159-109966, reverse complement, Verified ORF, "cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3p"
>YJL165C HAL5 SGDID:S000003701, Chr X from 109461-106894, reverse complement, Verified ORF, "Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters"
>YJL166W QCR8 SGDID:S000003702, Chr X from 106434-106718, Verified ORF, "Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p"
>YJL167W ERG20 SGDID:S000003703, Chr X from 105014-106072, Verified ORF, "Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis"
>YJL168C SET2 SGDID:S000003704, Chr X from 104428-102227, reverse complement, Verified ORF, "Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p"
>YJL169W YJL169W SGDID:S000003705, Chr X from 102099-102467, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2"
>YJL170C ASG7 SGDID:S000003706, Chr X from 101779-101150, reverse complement, Verified ORF, "Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor"
>YJL171C YJL171C SGDID:S000003707, Chr X from 100894-99704, reverse complement, Verified ORF, "GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein"
>YJL172W CPS1 SGDID:S000003708, Chr X from 97737-99467, Verified ORF, "Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions"
>YJL173C RFA3 SGDID:S000003709, Chr X from 96529-96161, reverse complement, Verified ORF, "Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination"
>YJL174W KRE9 SGDID:S000003710, Chr X from 95092-95922, Verified ORF, "Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects"
>YJL175W YJL175W SGDID:S000003711, Chr X from 94049-94561, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor"
>YJL176C SWI3 SGDID:S000003712, Chr X from 94530-92053, reverse complement, Verified ORF, "Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2"
>YJL177W RPL17B SGDID:S000003713, Chr X from 90786-91094,91412-91657, Verified ORF, "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Ap and has similarity to E. coli L22 and rat L17 ribosomal proteins"
>YJL178C ATG27 SGDID:S000003714, Chr X from 90097-89282, reverse complement, Verified ORF, "Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the phagophore assembly site"
>YJL179W PFD1 SGDID:S000003715, Chr X from 88787-89116, Verified ORF, "Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin"
>YJL180C ATP12 SGDID:S000003716, Chr X from 88560-87583, reverse complement, Verified ORF, "Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency"
>YJL181W YJL181W SGDID:S000003717, Chr X from 85660-87495, Uncharacterized ORF, "Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis"
>YJL182C YJL182C SGDID:S000003718, Chr X from 85752-85435, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YJL181W"
>YJL183W MNN11 SGDID:S000003719, Chr X from 84068-85336, Verified ORF, "Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p"
>YJL184W GON7 SGDID:S000003720, Chr X from 83448-83819, Verified ORF, "Protein proposed to be involved in the modification of N-linked oligosaccharides, osmotic stress response, telomere uncapping and elongation, transcription; component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Bud32p"
>YJL185C YJL185C SGDID:S000003721, Chr X from 82976-82095, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene"
>YJL186W MNN5 SGDID:S000003722, Chr X from 80155-81915, Verified ORF, "Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment"
>YJL187C SWE1 SGDID:S000003723, Chr X from 79262-76803, reverse complement, Verified ORF, "Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate"
>YJL188C BUD19 SGDID:S000003724, Chr X from 76510-76202, reverse complement, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay"
>YJL189W RPL39 SGDID:S000003725, Chr X from 75933-75938,76325-76474, Verified ORF, "Protein component of the large (60S) ribosomal subunit, has similarity to rat L39 ribosomal protein; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1"
>YJL190C RPS22A SGDID:S000003726, Chr X from 75302-74910, reverse complement, Verified ORF, "Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins"
>YJL191W RPS14B SGDID:S000003727, Chr X from 73787-73796,74205-74611, Verified ORF, "Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Ap and similar to E. coli S11 and rat S14 ribosomal proteins"
>YJL192C SOP4 SGDID:S000003728, Chr X from 73414-72710, reverse complement, Verified ORF, "ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER"
>YJL193W YJL193W SGDID:S000003729, Chr X from 71366-72574, Uncharacterized ORF, "Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect"
>YJL194W CDC6 SGDID:S000003730, Chr X from 69338-70879, Verified ORF, "Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p"
>YJL195C YJL195C SGDID:S000003731, Chr X from 69942-69241, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6"
>YJL196C ELO1 SGDID:S000003732, Chr X from 68782-67850, reverse complement, Verified ORF, "Elongase I, medium-chain acyl elongase, catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids"
>YJL197C-A YJL197C-A SGDID:S000028839, Chr X from 66086-65805, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL197C/UBP12"
>YJL197W UBP12 SGDID:S000003733, Chr X from 63805-67569, Verified ORF, "Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease present in the nucleus and cytoplasm that cleaves ubiquitin from ubiquitinated proteins"
>YJL198W PHO90 SGDID:S000003734, Chr X from 60844-63489, Verified ORF, "Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth"
>YJL199C MBB1 SGDID:S000003735, Chr X from 60182-59856, reverse complement, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies"
>YJL200C ACO2 SGDID:S000003736, Chr X from 58813-56444, reverse complement, Verified ORF, "Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol"
>YJL201W ECM25 SGDID:S000003737, Chr X from 54379-56178, Verified ORF, "Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p"
>YJL202C YJL202C SGDID:S000003738, Chr X from 54290-53943, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 3' end of essential PRP21 gene encoding a subunit of the SF3a splicing factor complex"
>YJL203W PRP21 SGDID:S000003739, Chr X from 53341-54183, Verified ORF, "Subunit of the SF3a splicing factor complex, required for spliceosome assembly"
>YJL204C RCY1 SGDID:S000003740, Chr X from 53151-50629, reverse complement, Verified ORF, "F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth"
>YJL205C NCE101 SGDID:S000003742, Chr X from 50268-50139,50443-50412, reverse complement, Verified ORF, "Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences"
>YJL206C YJL206C SGDID:S000003741, Chr X from 49935-47659, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induced rapidly upon MMS treatment"
>YJL207C LAA1 SGDID:S000003743, Chr X from 47433-41389, reverse complement, Verified ORF, "AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene"
>YJL208C NUC1 SGDID:S000003744, Chr X from 41183-40194, reverse complement, Verified ORF, "Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy"
>YJL209W CBP1 SGDID:S000003745, Chr X from 38005-39969, Verified ORF, "Mitochondrial protein that interacts with the 5'-untranslated region of the COB mRNA and has a role in its stability and translation; found in a complex at the inner membrane along with Pet309p"
>YJL210W PEX2 SGDID:S000003746, Chr X from 36919-37734, Verified ORF, "RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import"
>YJL211C YJL211C SGDID:S000003747, Chr X from 37200-36757, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2"
>YJL212C OPT1 SGDID:S000003748, Chr X from 36249-33850, reverse complement, Verified ORF, "Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family"
>YJL213W YJL213W SGDID:S000003749, Chr X from 32163-33158, Verified ORF, "Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p"
>YJL214W HXT8 SGDID:S000003750, Chr X from 26887-28596, Verified ORF, "Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose"
>YJL215C YJL215C SGDID:S000003751, Chr X from 26771-26412, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YJL216C IMA5 SGDID:S000003752, Chr X from 26086-24341, reverse complement, Verified ORF, "Alpha-glucosidase with specificity for isomaltose, maltose, and palatinose; member of the IMA isomaltase family; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose"
>YJL217W REE1 SGDID:S000003753, Chr X from 23133-23729, Verified ORF, "Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle"
>YJL218W YJL218W SGDID:S000003754, Chr X from 21973-22563, Uncharacterized ORF, "Putative protein of unknown function, similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene"
>YJL219W HXT9 SGDID:S000003755, Chr X from 19497-21200, Verified ORF, "Putative hexose transporter that is nearly identical to Hxt11p, has similarity to major facilitator superfamily (MFS) transporters, expression of HXT9 is regulated by transcription factors Pdr1p and Pdr3p"
>YJL220W YJL220W SGDID:S000003756, Chr X from 18243-18695, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL221C/FSP2"
>YJL221C IMA4 SGDID:S000003757, Chr X from 18536-16767, reverse complement, Verified ORF, "Alpha-glucosidase with broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides; member of IMA isomaltase family; not required for isomaltose utilization, but Ima4p overexpression allows the ima1 null mutant to grow on isomaltose"
>YJL222W VTH2 SGDID:S000003758, Chr X from 11475-16124, Verified ORF, "Putative membrane glycoprotein with strong similarity to Vth1p and Pep1p/Vps10p, may be involved in vacuolar protein sorting"
>YJL222W-A YJL222W-A SGDID:S000028663, Chr X from 9452-9679, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YJL222W-B YJL222W-B SGDID:S000028664, Chr X from 9346-9483, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YJL223C PAU1 SGDID:S000003759, Chr X from 9138-8776, reverse complement, Verified ORF, "Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme; identical to Pau14p"
>YJL225C YJL225C SGDID:S000003760, Chr X from 4581-466,6130-4970, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; similarity to DNA helicases that are also encoded within subtelomeric Y' elements and induced in telomerase deficient survivors"
>YJL225W-A YJL225W-A SGDID:S000028665, Chr X from 829-1311, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene YJL225C"
>YJR001W AVT1 SGDID:S000003761, Chr X from 436802-438610, Verified ORF, "Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters"
>YJR002W MPP10 SGDID:S000003762, Chr X from 438865-440646, Verified ORF, "Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p"
>YJR003C YJR003C SGDID:S000003763, Chr X from 442553-440994, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis"
>YJR004C SAG1 SGDID:S000003764, Chr X from 444861-442909, reverse complement, Verified ORF, "Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor"
>YJR005C-A YJR005C-A SGDID:S000028523, Chr X from 448758-448477, reverse complement, Uncharacterized ORF, "Putative protein of unknown function, originally identified as a syntenic homolog of an <i>Ashbya gossypii</i> gene"
>YJR005W APL1 SGDID:S000003765, Chr X from 445923-448025, Verified ORF, "Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex"
>YJR006W POL31 SGDID:S000003766, Chr X from 449202-450665, Verified ORF, "DNA polymerase III (delta) subunit, essential for cell viability; involved in DNA replication and DNA repair"
>YJR007W SUI2 SGDID:S000003767, Chr X from 451020-451934, Verified ORF, "Alpha subunit of the translation initiation factor eIF2, involved in the identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP"
>YJR008W YJR008W SGDID:S000003768, Chr X from 452430-453446, Uncharacterized ORF, "Putative protein of unknown function; expression repressed by inosine and choline in an Opi1p-dependent manner; expression induced by mild heat-stress on a non-fermentable carbon source."
>YJR009C TDH2 SGDID:S000003769, Chr X from 454681-453683, reverse complement, Verified ORF, "Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall"
>YJR010C-A SPC1 SGDID:S000003770, Chr X from 458361-458077, reverse complement, Verified ORF, "Subunit of the signal peptidase complex (SPC), which cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER), homolog of the SPC12 subunit of mammalian signal peptidase complex"
>YJR010W MET3 SGDID:S000003771, Chr X from 456239-457774, Verified ORF, "ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism"
>YJR011C YJR011C SGDID:S000003772, Chr X from 459426-458641, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS"
>YJR012C YJR012C SGDID:S000003773, Chr X from 460418-459795, reverse complement, Uncharacterized ORF, "Essential protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W"
>YJR013W GPI14 SGDID:S000003774, Chr X from 460382-461593, Verified ORF, "Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M"
>YJR014W TMA22 SGDID:S000003775, Chr X from 461829-462425, Verified ORF, "Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1"
>YJR015W YJR015W SGDID:S000003776, Chr X from 462721-464253, Uncharacterized ORF, "Putative protein of unknown function; localizes to the endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; YJR015W is a non-essential gene"
>YJR016C ILV3 SGDID:S000003777, Chr X from 466208-464451, reverse complement, Verified ORF, "Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids"
>YJR017C ESS1 SGDID:S000003778, Chr X from 467033-466521, reverse complement, Verified ORF, "Peptidylprolyl-cis/trans-isomerase (PPIase) specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNA polymerase II large subunit (Rpo21p) C-terminal domain"
>YJR018W YJR018W SGDID:S000003779, Chr X from 466786-467148, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YJR019C TES1 SGDID:S000003780, Chr X from 468281-467232, reverse complement, Verified ORF, "Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids"
>YJR020W YJR020W SGDID:S000003781, Chr X from 468001-468333, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YJR021C REC107 SGDID:S000003782, Chr X from 469183-468555,469579-469264, reverse complement, Verified ORF, "Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation"
>YJR022W LSM8 SGDID:S000003783, Chr X from 469784-470113, Verified ORF, "Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA"
>YJR023C YJR023C SGDID:S000003784, Chr X from 470205-469804, reverse complement, Dubious ORF, "Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing"
>YJR024C MDE1 SGDID:S000003785, Chr X from 470964-470230, reverse complement, Verified ORF, "5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant"
>YJR025C BNA1 SGDID:S000003786, Chr X from 471671-471138, reverse complement, Verified ORF, "3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p"
>YJR026W YJR026W SGDID:S000003787, Chr X from 472760-474082, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YJR027W YJR027W SGDID:S000003788, Chr X from 472760-474061,474063-478028, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YJR028W YJR028W SGDID:S000003789, Chr X from 478344-479666, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YJR029W YJR029W SGDID:S000003790, Chr X from 478344-479644,479646-483612, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YJR030C YJR030C SGDID:S000003791, Chr X from 486196-483959, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; expression repressed in carbon limited vs carbon replete chemostat cultures; YJR030C is a non-essential gene"
>YJR031C GEA1 SGDID:S000003792, Chr X from 490812-486586, reverse complement, Verified ORF, "Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea2p"
>YJR032W CPR7 SGDID:S000003793, Chr X from 491081-492262, Verified ORF, "Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity"
>YJR033C RAV1 SGDID:S000003794, Chr X from 496451-492378, reverse complement, Verified ORF, "Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate"
>YJR034W PET191 SGDID:S000003795, Chr X from 496683-497009, Verified ORF, "Protein required for assembly of cytochrome c oxidase; exists as an oligomer that is integral to the mitochondrial inner membrane and faces the intermembrane space; contains a twin Cx9C motif"
>YJR035W RAD26 SGDID:S000003796, Chr X from 497355-500612, Verified ORF, "Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein"
>YJR036C HUL4 SGDID:S000003797, Chr X from 503391-500713, reverse complement, Verified ORF, "Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability"
>YJR037W YJR037W SGDID:S000003798, Chr X from 503102-503485, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; deletion mutant has decreased spore survival in Drosophila feces"
>YJR038C YJR038C SGDID:S000003799, Chr X from 504072-503710, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YJR039W YJR039W SGDID:S000003800, Chr X from 503936-507301, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YJR040W GEF1 SGDID:S000003801, Chr X from 507746-510085, Verified ORF, "Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels"
>YJR041C URB2 SGDID:S000003802, Chr X from 513763-510239, reverse complement, Verified ORF, "Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis"
>YJR042W NUP85 SGDID:S000003803, Chr X from 514055-516289, Verified ORF, "Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), required for assembly of the subcomplex and also for formation of the nucleocytoplasmic Gsp1p concentration gradient that plays a role in nuclear trafficking"
>YJR043C POL32 SGDID:S000003804, Chr X from 517513-516461, reverse complement, Verified ORF, "Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p"
>YJR044C VPS55 SGDID:S000003805, Chr X from 519185-518763, reverse complement, Verified ORF, "Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP)"
>YJR045C SSC1 SGDID:S000003806, Chr X from 521602-519638, reverse complement, Verified ORF, "Hsp70 family ATPase, constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein translocation and folding; subunit of SceI endonuclease"
>YJR046W TAH11 SGDID:S000003807, Chr X from 522048-523862, Verified ORF, "DNA replication licensing factor, required for pre-replication complex assembly"
>YJR047C ANB1 SGDID:S000003808, Chr X from 525381-524908, reverse complement, Verified ORF, "Translation elongation factor eIF-5A, previously thought to function in translation initiation; similar to and functionally redundant with Hyp2p; undergoes an essential hypusination modification; expressed under anaerobic conditions"
>YJR048W CYC1 SGDID:S000003809, Chr X from 526335-526664, Verified ORF, "Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration"
>YJR049C UTR1 SGDID:S000003810, Chr X from 528476-526884, reverse complement, Verified ORF, "ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p)"
>YJR050W ISY1 SGDID:S000003811, Chr X from 528697-529404, Verified ORF, "Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles"
>YJR051W OSM1 SGDID:S000003812, Chr X from 529861-531366, Verified ORF, "Fumarate reductase, catalyzes the reduction of fumarate to succinate, required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity"
>YJR052W RAD7 SGDID:S000003813, Chr X from 532062-533759, Verified ORF, "Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex"
>YJR053W BFA1 SGDID:S000003814, Chr X from 534027-535751, Verified ORF, "Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis"
>YJR054W YJR054W SGDID:S000003815, Chr X from 536056-537549, Uncharacterized ORF, "Vacuolar protein of unknown function; potential Cdc28p substrate"
>YJR055W HIT1 SGDID:S000003816, Chr X from 538772-539266, Verified ORF, "Protein of unknown function, required for growth at high temperature"
>YJR056C YJR056C SGDID:S000003817, Chr X from 542502-541792, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus"
>YJR057W CDC8 SGDID:S000003818, Chr X from 544062-544712, Verified ORF, "Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p"
>YJR058C APS2 SGDID:S000003819, Chr X from 545175-544732, reverse complement, Verified ORF, "Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex"
>YJR059W PTK2 SGDID:S000003820, Chr X from 545787-548243, Verified ORF, "Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake"
>YJR060W CBF1 SGDID:S000003821, Chr X from 548759-549814, Verified ORF, "Helix-loop-helix protein that binds the motif CACRTG, which is present at several sites including MET gene promoters and centromere DNA element I (CDEI); required for nucleosome positioning at this motif; targets Isw1p to DNA"
>YJR061W YJR061W SGDID:S000003822, Chr X from 550511-553318, Uncharacterized ORF, "Putative protein of unknown function; non-essential gene with similarity to Mnn4, a putative membrane protein involved in glycosylation; transcription repressed by Rm101p"
>YJR062C NTA1 SGDID:S000003823, Chr X from 554849-553476, reverse complement, Verified ORF, "Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation"
>YJR063W RPA12 SGDID:S000003824, Chr X from 555195-555572, Verified ORF, "RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex"
>YJR064W CCT5 SGDID:S000003825, Chr X from 555914-557602, Verified ORF, "Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo"
>YJR065C ARP3 SGDID:S000003826, Chr X from 559158-557809, reverse complement, Verified ORF, "Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity"
>YJR066W TOR1 SGDID:S000003827, Chr X from 559416-566828, Verified ORF, "PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis"
>YJR067C YAE1 SGDID:S000003828, Chr X from 567444-567019, reverse complement, Verified ORF, "Protein of unknown function, essential for growth under standard (aerobic) conditions but not under anaerobic conditions"
>YJR068W RFC2 SGDID:S000003829, Chr X from 567643-568704, Verified ORF, "Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon"
>YJR069C HAM1 SGDID:S000003830, Chr X from 569399-568806, reverse complement, Verified ORF, "Conserved protein with deoxyribonucleoside triphosphate pyrophosphohydrolase activity, mediates exclusion of noncanonical purines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine"
>YJR070C LIA1 SGDID:S000003831, Chr X from 570598-569621, reverse complement, Verified ORF, "Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning"
>YJR071W YJR071W SGDID:S000003832, Chr X from 570405-570773, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YJR072C NPA3 SGDID:S000003833, Chr X from 572124-570967, reverse complement, Verified ORF, "Essential, conserved, cytoplasmic ATPase; phosphorylated by the Pcl1p-Pho85p kinase complex"
>YJR073C OPI3 SGDID:S000003834, Chr X from 572935-572315, reverse complement, Verified ORF, "Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis"
>YJR074W MOG1 SGDID:S000003835, Chr X from 573095-573751, Verified ORF, "Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p"
>YJR075W HOC1 SGDID:S000003836, Chr X from 573981-575171, Verified ORF, "Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele"
>YJR076C CDC11 SGDID:S000003837, Chr X from 576601-575354, reverse complement, Verified ORF, "Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM"
>YJR077C MIR1 SGDID:S000003838, Chr X from 578190-577255, reverse complement, Verified ORF, "Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated"
>YJR078W BNA2 SGDID:S000003839, Chr X from 578860-580221, Verified ORF, "Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp"
>YJR079W YJR079W SGDID:S000003840, Chr X from 580205-580347,581053-581239, Uncharacterized ORF, "Putative protein of unknown function; mutation results in impaired mitochondrial respiration"
>YJR080C AIM24 SGDID:S000003841, Chr X from 581616-580432, reverse complement, Verified ORF, "Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss"
>YJR082C EAF6 SGDID:S000003842, Chr X from 582255-581914, reverse complement, Verified ORF, "Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3"
>YJR083C ACF4 SGDID:S000003843, Chr X from 583537-582608, reverse complement, Verified ORF, "Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate"
>YJR084W CSN12 SGDID:S000003844, Chr X from 583733-585004, Verified ORF, "Protein that forms a complex with Thp3p; may have a role in transcription elongation and/or mRNA splicing; identified as a COP9 signalosome component but phenotype and interactions suggest it may not be involved with the signalosome"
>YJR085C YJR085C SGDID:S000003845, Chr X from 585437-585120, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YJR086W STE18 SGDID:S000003846, Chr X from 586068-586400, Verified ORF, "G protein gamma subunit, forms a dimer with Ste4p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste4p to dampen signaling; C-terminus is palmitoylated and farnesylated, which are required for normal signaling"
>YJR087W YJR087W SGDID:S000003847, Chr X from 586400-586750, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene STE18 and uncharacterized ORF YJR088C"
>YJR088C EMC2 SGDID:S000003848, Chr X from 587373-586495, reverse complement, Verified ORF, "Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response"
>YJR089W BIR1 SGDID:S000003849, Chr X from 587718-590582, Verified ORF, "Subunit of chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates chromosome segregation; required for chromosome bi-orientation and for spindle assembly checkpoint activation upon reduced sister kinetochore tension"
>YJR090C GRR1 SGDID:S000003850, Chr X from 594327-590872, reverse complement, Verified ORF, "F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification"
>YJR091C JSN1 SGDID:S000003851, Chr X from 598336-595061, reverse complement, Verified ORF, "Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl"
>YJR092W BUD4 SGDID:S000003852, Chr X from 598735-603078, Verified ORF, "Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding; potential Cdc28p substrate"
>YJR093C FIP1 SGDID:S000003853, Chr X from 604203-603220, reverse complement, Verified ORF, "Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity"
>YJR094C IME1 SGDID:S000003854, Chr X from 605651-604569, reverse complement, Verified ORF, "Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p"
>YJR094W-A RPL43B SGDID:S000003855, Chr X from 608305-608306,608582-608858, Verified ORF, "Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein"
>YJR095W SFC1 SGDID:S000003856, Chr X from 609773-610741, Verified ORF, "Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization"
>YJR096W YJR096W SGDID:S000003857, Chr X from 611195-612043, Verified ORF, "Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS"
>YJR097W JJJ3 SGDID:S000003858, Chr X from 612413-612931, Verified ORF, "Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein"
>YJR098C YJR098C SGDID:S000003859, Chr X from 615156-613186, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YJR099W YUH1 SGDID:S000003860, Chr X from 615576-616286, Verified ORF, "Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p"
>YJR100C AIM25 SGDID:S000003861, Chr X from 617334-616351, reverse complement, Verified ORF, "Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss"
>YJR101W RSM26 SGDID:S000003862, Chr X from 618234-619034, Verified ORF, "Mitochondrial ribosomal protein of the small subunit"
>YJR102C VPS25 SGDID:S000003863, Chr X from 619765-619157, reverse complement, Verified ORF, "Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome"
>YJR103W URA8 SGDID:S000003864, Chr X from 620754-622490, Verified ORF, "Minor CTP synthase isozyme (see also URA7), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis"
>YJR104C SOD1 SGDID:S000003865, Chr X from 623014-622550, reverse complement, Verified ORF, "Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans"
>YJR105W ADO1 SGDID:S000003866, Chr X from 623581-624603, Verified ORF, "Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle"
>YJR106W ECM27 SGDID:S000003867, Chr X from 624838-627015, Verified ORF, "Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p"
>YJR107W YJR107W SGDID:S000003868, Chr X from 627340-628326, Uncharacterized ORF, "Putative protein of unknown function; has sequence or structural similarity to lipases"
>YJR108W ABM1 SGDID:S000003869, Chr X from 628712-629083, Verified ORF, "Protein of unknown function, required for normal microtubule organization"
>YJR109C CPA2 SGDID:S000003870, Chr X from 632941-629585, reverse complement, Verified ORF, "Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor"
>YJR110W YMR1 SGDID:S000003871, Chr X from 633615-635681, Verified ORF, "Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family"
>YJR111C YJR111C SGDID:S000003872, Chr X from 636706-635855, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria"
>YJR112W NNF1 SGDID:S000003873, Chr X from 637030-637635, Verified ORF, "Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation"
>YJR112W-A YJR112W-A SGDID:S000028513, Chr X from 637790-637809,637859-638168, Uncharacterized ORF, "Putative protein of unknown function; identified based on homology to <i>Ashbya gossypii</i>"
>YJR113C RSM7 SGDID:S000003874, Chr X from 638975-638232, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein"
>YJR114W YJR114W SGDID:S000003875, Chr X from 638659-639051, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSM7/YJR113C"
>YJR115W YJR115W SGDID:S000003876, Chr X from 639942-640451, Uncharacterized ORF, "Putative protein of unknown function"
>YJR116W YJR116W SGDID:S000003877, Chr X from 640825-641664, Uncharacterized ORF, "Putative protein of unknown function"
>YJR117W STE24 SGDID:S000003878, Chr X from 642007-643368, Verified ORF, "Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans"
>YJR118C ILM1 SGDID:S000003879, Chr X from 644101-643490, reverse complement, Verified ORF, "Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth"
>YJR119C JHD2 SGDID:S000003880, Chr X from 646490-644304, reverse complement, Verified ORF, "JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation"
>YJR120W YJR120W SGDID:S000003881, Chr X from 647126-647476, Verified ORF, "Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p"
>YJR121W ATP2 SGDID:S000003882, Chr X from 647607-649142, Verified ORF, "Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated"
>YJR122W IBA57 SGDID:S000003883, Chr X from 649776-651269, Verified ORF, "Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system"
>YJR123W RPS5 SGDID:S000003884, Chr X from 651901-652578, Verified ORF, "Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins"
>YJR124C YJR124C SGDID:S000003885, Chr X from 654238-652892, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; expression induced under calcium shortage"
>YJR125C ENT3 SGDID:S000003886, Chr X from 655963-654737, reverse complement, Verified ORF, "Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p"
>YJR126C VPS70 SGDID:S000003887, Chr X from 658689-656254, reverse complement, Verified ORF, "Protein of unknown function involved in vacuolar protein sorting"
>YJR127C RSF2 SGDID:S000003888, Chr X from 663059-658917, reverse complement, Verified ORF, "Zinc-finger protein involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions"
>YJR128W YJR128W SGDID:S000003889, Chr X from 662921-663280, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2"
>YJR129C YJR129C SGDID:S000003890, Chr X from 665019-664000, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"
>YJR130C STR2 SGDID:S000003891, Chr X from 667137-665218, reverse complement, Verified ORF, "Cystathionine gamma-synthase, converts cysteine into cystathionine"
>YJR131W MNS1 SGDID:S000003892, Chr X from 667644-669293, Verified ORF, "Alpha-1,2-mannosidase involved in ER quality control; catalyzes the removal of one mannose residue from Man9GlcNAc to produce a single isomer of Man8GlcNAc in N-linked oligosaccharide biosynthesis; integral to ER membrane"
>YJR132W NMD5 SGDID:S000003893, Chr X from 669522-672668, Verified ORF, "Karyopherin, a carrier protein involved in nuclear import of proteins; importin beta homolog"
>YJR133W XPT1 SGDID:S000003894, Chr X from 672991-673620, Verified ORF, "Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine"
>YJR134C SGM1 SGDID:S000003895, Chr X from 675852-673729, reverse complement, Verified ORF, "Protein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus"
>YJR135C MCM22 SGDID:S000003896, Chr X from 676778-676059, reverse complement, Verified ORF, "Protein involved in minichromosome maintenance; component of the kinetochore; binds to centromeric DNA in a Ctf19p-dependent manner"
>YJR135W-A TIM8 SGDID:S000007348, Chr X from 676971-677234, Verified ORF, "Mitochondrial intermembrane space protein, forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome"
>YJR136C TTI2 SGDID:S000003897, Chr X from 678706-677441, reverse complement, Verified ORF, "Putative protein of unknown function; subunit of the ASTRA complex which is part of the chromatin remodeling machinery; similar to S. pombe Tti2p; may interact with Rsm23p; GFP-fusion protein localizes to the cytoplasm"
>YJR137C MET5 SGDID:S000003898, Chr X from 683285-678957, reverse complement, Verified ORF, "Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine"
>YJR138W IML1 SGDID:S000003899, Chr X from 684567-689321, Verified ORF, "Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane"
>YJR139C HOM6 SGDID:S000003900, Chr X from 690524-689445, reverse complement, Verified ORF, "Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions"
>YJR140C HIR3 SGDID:S000003901, Chr X from 695696-690750, reverse complement, Verified ORF, "Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly"
>YJR140W-A YJR140W-A SGDID:S000028666, Chr X from 690961-691110, Dubious ORF, "Dubious open reading frame; completely overlaps the verified gene HIR3; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YJR141W YJR141W SGDID:S000003902, Chr X from 695906-696949, Uncharacterized ORF, "Essential protein of unknown function"
>YJR142W YJR142W SGDID:S000003903, Chr X from 697141-698169, Uncharacterized ORF, "Putative protein of unknown function; GST fusion protein is a Dbf2-Mob1 phosphoylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition"
>YJR143C PMT4 SGDID:S000003904, Chr X from 700614-698326, reverse complement, Verified ORF, "Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; appears to form homodimers in vivo and does not complex with other Pmt proteins; target for new antifungals"
>YJR144W MGM101 SGDID:S000003905, Chr X from 700882-701691, Verified ORF, "Protein involved in mitochondrial genome maintenance; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage"
>YJR145C RPS4A SGDID:S000003906, Chr X from 702798-702027,703068-703055, reverse complement, Verified ORF, "Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein"
>YJR146W YJR146W SGDID:S000003907, Chr X from 703885-704238, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2"
>YJR147W HMS2 SGDID:S000003908, Chr X from 704196-705272, Verified ORF, "Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant"
>YJR148W BAT2 SGDID:S000003909, Chr X from 705744-706874, Verified ORF, "Cytosolic branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase"
>YJR149W YJR149W SGDID:S000003910, Chr X from 707160-708374, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"
>YJR150C DAN1 SGDID:S000003911, Chr X from 709707-708811, reverse complement, Verified ORF, "Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth"
>YJR151C DAN4 SGDID:S000003912, Chr X from 715740-712255, reverse complement, Verified ORF, "Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth"
>YJR151W-A YJR151W-A SGDID:S000028557, Chr X from 717580-717630, Uncharacterized ORF, "Putative protein of unknown function; identified by fungal homology and RT-PCR; predicted to have a role in transcription based on computational "guilt by association" analysis"
>YJR152W DAL5 SGDID:S000003913, Chr X from 719666-721297, Verified ORF, "Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression"
>YJR153W PGU1 SGDID:S000003914, Chr X from 722815-723900, Verified ORF, "Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins"
>YJR154W YJR154W SGDID:S000003915, Chr X from 725784-726824, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"
>YJR155W AAD10 SGDID:S000003916, Chr X from 727405-728271, Verified ORF, "Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role"
>YJR156C THI11 SGDID:S000003917, Chr X from 729596-728574, reverse complement, Verified ORF, "Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13"
>YJR157W YJR157W SGDID:S000003918, Chr X from 730515-730877, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YJR158W HXT16 SGDID:S000003919, Chr X from 732440-734143, Verified ORF, "Protein of unknown function with similarity to hexose transporter family members, expression is repressed by high levels of glucose"
>YJR159W SOR1 SGDID:S000003920, Chr X from 736044-737117, Verified ORF, "Sorbitol dehydrogenase; expression is induced in the presence of sorbitol or xylose"
>YJR160C MPH3 SGDID:S000003921, Chr X from 739816-738008, reverse complement, Verified ORF, "Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph2p; encoded in a subtelomeric position in a region likely to have undergone duplication"
>YJR161C COS5 SGDID:S000003922, Chr X from 743999-742848, reverse complement, Verified ORF, "Protein of unknown function, member the DUP380 subfamily of conserved, often subtelomerically-encoded proteins"
>YJR162C YJR162C SGDID:S000003923, Chr X from 745261-744911, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YKL001C MET14 SGDID:S000001484, Chr XI from 439385-438777, reverse complement, Verified ORF, "Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism"
>YKL002W DID4 SGDID:S000001485, Chr XI from 437778-437837,437906-438544, Verified ORF, "Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis"
>YKL003C MRP17 SGDID:S000001486, Chr XI from 437492-437097, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator"
>YKL004W AUR1 SGDID:S000001487, Chr XI from 435580-436785, Verified ORF, "Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance"
>YKL005C BYE1 SGDID:S000001488, Chr XI from 434877-433093, reverse complement, Verified ORF, "Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit"
>YKL006C-A SFT1 SGDID:S000002101, Chr XI from 430455-430198,430632-430597, reverse complement, Verified ORF, "Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment"
>YKL006W RPL14A SGDID:S000001489, Chr XI from 431906-432034,432433-432720, Verified ORF, "N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Bp and has similarity to rat L14 ribosomal protein; rpl14a csh5 double null mutant exhibits synthetic slow growth"
>YKL007W CAP1 SGDID:S000001490, Chr XI from 429302-430108, Verified ORF, "Alpha subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches"
>YKL008C LAC1 SGDID:S000001491, Chr XI from 428551-427295, reverse complement, Verified ORF, "Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p"
>YKL009W MRT4 SGDID:S000001492, Chr XI from 426242-426952, Verified ORF, "Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus"
>YKL010C UFD4 SGDID:S000001493, Chr XI from 425875-421424, reverse complement, Verified ORF, "Ubiquitin-protein ligase (E3) that interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins"
>YKL011C CCE1 SGDID:S000001494, Chr XI from 421216-420155, reverse complement, Verified ORF, "Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA"
>YKL012W PRP40 SGDID:S000001495, Chr XI from 418310-420061, Verified ORF, "U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex"
>YKL013C ARC19 SGDID:S000001496, Chr XI from 418023-417508, reverse complement, Verified ORF, "Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches"
>YKL014C URB1 SGDID:S000001497, Chr XI from 416913-411619, reverse complement, Verified ORF, "Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit"
>YKL015W PUT3 SGDID:S000001498, Chr XI from 408544-411483, Verified ORF, "Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences and undergoes a conformational change to form the active state; has a Zn(2)-Cys(6) binuclear cluster domain"
>YKL016C ATP7 SGDID:S000001499, Chr XI from 407989-407465, reverse complement, Verified ORF, "Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis"
>YKL017C HCS1 SGDID:S000001500, Chr XI from 407241-405190, reverse complement, Verified ORF, "Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities"
>YKL018C-A YKL018C-A SGDID:S000007615, Chr XI from 403879-403580, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"
>YKL018W SWD2 SGDID:S000001501, Chr XI from 404102-405091, Verified ORF, "Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination"
>YKL019W RAM2 SGDID:S000001502, Chr XI from 402568-403518, Verified ORF, "Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor"
>YKL020C SPT23 SGDID:S000001503, Chr XI from 402080-398832, reverse complement, Verified ORF, "ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting"
>YKL021C MAK11 SGDID:S000001504, Chr XI from 398750-397344, reverse complement, Verified ORF, "Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats"
>YKL022C CDC16 SGDID:S000001505, Chr XI from 397248-394726, reverse complement, Verified ORF, "Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation"
>YKL023C-A YKL023C-A SGDID:S000113559, Chr XI from 393373-393146, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YKL023W YKL023W SGDID:S000001506, Chr XI from 393721-394554, Uncharacterized ORF, "Putative protein of unknown function, predicted by computational methods to be involved in mRNA degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"
>YKL024C URA6 SGDID:S000001507, Chr XI from 393140-392526, reverse complement, Verified ORF, "Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)"
>YKL025C PAN3 SGDID:S000001508, Chr XI from 392279-390240, reverse complement, Verified ORF, "Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes"
>YKL026C GPX1 SGDID:S000001509, Chr XI from 389883-389380, reverse complement, Verified ORF, "Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress"
>YKL027W YKL027W SGDID:S000001510, Chr XI from 387562-388905, Verified ORF, "Protein of unknown function, localized to the mitochondrial outer membrane"
>YKL028W TFA1 SGDID:S000001511, Chr XI from 385758-387206, Verified ORF, "TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening"
>YKL029C MAE1 SGDID:S000001512, Chr XI from 384725-382716, reverse complement, Verified ORF, "Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids"
>YKL030W YKL030W SGDID:S000001513, Chr XI from 382498-383103, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified gene MAE1"
>YKL031W YKL031W SGDID:S000001514, Chr XI from 382072-382485, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species"
>YKL032C IXR1 SGDID:S000001515, Chr XI from 381858-380065, reverse complement, Verified ORF, "Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b"
>YKL033W TTI1 SGDID:S000001516, Chr XI from 375456-378572, Verified ORF, "Putative protein of unknown function; subunit of the ASTRA complex which is part of the chromatin remodeling machinery; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies"
>YKL033W-A YKL033W-A SGDID:S000007242, Chr XI from 374505-375215, Uncharacterized ORF, "Putative protein of unknown function; similar to uncharacterized proteins from other fungi"
>YKL034W TUL1 SGDID:S000001517, Chr XI from 371829-374105, Verified ORF, "Golgi-localized RING-finger ubiquitin ligase (E3), involved in ubiquitinating and sorting membrane proteins that contain polar transmembrane domains to multivesicular bodies for delivery to the vacuole for quality control purposes"
>YKL035W UGP1 SGDID:S000001518, Chr XI from 369891-371390, Verified ORF, "UDP-glucose pyrophosphorylase (UGPase), catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p"
>YKL036C YKL036C SGDID:S000001519, Chr XI from 369920-369528, reverse complement, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W"
>YKL037W AIM26 SGDID:S000001520, Chr XI from 369365-369721, Verified ORF, "Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT"
>YKL038W RGT1 SGDID:S000001521, Chr XI from 365605-369117, Verified ORF, "Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor"
>YKL039W PTM1 SGDID:S000001522, Chr XI from 362622-364193, Verified ORF, "Protein of unknown function, copurifies with late Golgi vesicles containing the v-SNARE Tlg2p"
>YKL040C NFU1 SGDID:S000001523, Chr XI from 361828-361058, reverse complement, Verified ORF, "Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria"
>YKL041W VPS24 SGDID:S000001524, Chr XI from 360143-360817, Verified ORF, "One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway"
>YKL042W SPC42 SGDID:S000001525, Chr XI from 358475-359566, Verified ORF, "Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane"
>YKL043W PHD1 SGDID:S000001526, Chr XI from 356748-357848, Verified ORF, "Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate"
>YKL044W YKL044W SGDID:S000001527, Chr XI from 356322-356642, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YKL045W PRI2 SGDID:S000001528, Chr XI from 353493-355079, Verified ORF, "Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair"
>YKL046C DCW1 SGDID:S000001529, Chr XI from 352624-351275, reverse complement, Verified ORF, "Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p"
>YKL047W YKL047W SGDID:S000001530, Chr XI from 349463-351013, Uncharacterized ORF, "Putative protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"
>YKL048C ELM1 SGDID:S000001531, Chr XI from 349136-347214, reverse complement, Verified ORF, "Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases; forms part of the bud neck ring"
>YKL049C CSE4 SGDID:S000001532, Chr XI from 346764-346075, reverse complement, Verified ORF, "Centromere protein that resembles histone H3, required for proper kinetochore function; homolog of human CENP-A; levels are regulated by E3 ubiquitin ligase Psh1p"
>YKL050C YKL050C SGDID:S000001533, Chr XI from 345620-342852, reverse complement, Verified ORF, "Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p"
>YKL051W SFK1 SGDID:S000001534, Chr XI from 341312-342373, Verified ORF, "Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane"
>YKL052C ASK1 SGDID:S000001535, Chr XI from 340546-339668, reverse complement, Verified ORF, "Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases"
>YKL053C-A MDM35 SGDID:S000007243, Chr XI from 339442-339182, reverse complement, Verified ORF, "Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs"
>YKL053W YKL053W SGDID:S000001536, Chr XI from 339572-339946, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ASK1"
>YKL054C DEF1 SGDID:S000001537, Chr XI from 338753-336537, reverse complement, Verified ORF, "RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis"
>YKL055C OAR1 SGDID:S000001538, Chr XI from 336157-335321, reverse complement, Verified ORF, "Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p"
>YKL056C TMA19 SGDID:S000001539, Chr XI from 334915-334412, reverse complement, Verified ORF, "Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress"
>YKL057C NUP120 SGDID:S000001540, Chr XI from 333969-330856, reverse complement, Verified ORF, "Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), required for even distribution of NPCs around the nuclear envelope, involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p"
>YKL058W TOA2 SGDID:S000001541, Chr XI from 330166-330534, Verified ORF, "TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA"
>YKL059C MPE1 SGDID:S000001542, Chr XI from 329443-328118, reverse complement, Verified ORF, "Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif"
>YKL060C FBA1 SGDID:S000001543, Chr XI from 327487-326408, reverse complement, Verified ORF, "Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress"
>YKL061W BLI1 SGDID:S000001544, Chr XI from 325771-326112, Uncharacterized ORF, "Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome"
>YKL062W MSN4 SGDID:S000001545, Chr XI from 323228-325120, Verified ORF, "Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression"
>YKL063C YKL063C SGDID:S000001546, Chr XI from 321518-321015, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi"
>YKL064W MNR2 SGDID:S000001547, Chr XI from 317764-320673, Verified ORF, "Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations"
>YKL065C YET1 SGDID:S000001548, Chr XI from 317057-316437, reverse complement, Verified ORF, "Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein"
>YKL065W-A YKL065W-A SGDID:S000113563, Chr XI from 315954-316175, Uncharacterized ORF, "Putative protein of unknown function"
>YKL066W YKL066W SGDID:S000001549, Chr XI from 315281-315724, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified gene YNK1"
>YKL067W YNK1 SGDID:S000001550, Chr XI from 314812-315273, Verified ORF, "Nucleoside diphosphate kinase, catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate"
>YKL068W NUP100 SGDID:S000001551, Chr XI from 310199-313078, Verified ORF, "Subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup116p"
>YKL068W-A YKL068W-A SGDID:S000028524, Chr XI from 309206-309442, Uncharacterized ORF, "Putative protein of unknown function; identified by homology to <i>Ashbya gossypii</i>"
>YKL069W YKL069W SGDID:S000001552, Chr XI from 307285-307827, Verified ORF, "Methionine-R-sulfoxide reductase, reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress"
>YKL070W YKL070W SGDID:S000001553, Chr XI from 306211-306720, Uncharacterized ORF, "Putative protein of unknown function; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YKL071W YKL071W SGDID:S000001554, Chr XI from 305114-305884, Uncharacterized ORF, "Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"
>YKL072W STB6 SGDID:S000001555, Chr XI from 299582-301882, Verified ORF, "Protein that binds Sin3p in a two-hybrid assay"
>YKL073W LHS1 SGDID:S000001556, Chr XI from 296430-299075, Verified ORF, "Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway"
>YKL074C MUD2 SGDID:S000001557, Chr XI from 296193-294610, reverse complement, Verified ORF, "Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65"
>YKL075C YKL075C SGDID:S000001558, Chr XI from 294308-292956, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin"
>YKL076C PSY1 SGDID:S000001559, Chr XI from 293221-292838, reverse complement, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C"
>YKL077W YKL077W SGDID:S000001560, Chr XI from 291453-292631, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole"
>YKL078W DHR2 SGDID:S000001561, Chr XI from 288845-291052, Verified ORF, "Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis"
>YKL079W SMY1 SGDID:S000001562, Chr XI from 286603-288573, Verified ORF, "Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins"
>YKL080W VMA5 SGDID:S000001563, Chr XI from 285030-286208, Verified ORF, "Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane"
>YKL081W TEF4 SGDID:S000001564, Chr XI from 282891-283095,283422-284455, Verified ORF, "Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex"
>YKL082C RRP14 SGDID:S000001565, Chr XI from 282329-281025, reverse complement, Verified ORF, "Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family"
>YKL083W YKL083W SGDID:S000001566, Chr XI from 280921-281535, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified essential gene RRP14"
>YKL084W HOT13 SGDID:S000001567, Chr XI from 280509-280859, Verified ORF, "Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc"
>YKL085W MDH1 SGDID:S000001568, Chr XI from 279123-280127, Verified ORF, "Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated"
>YKL086W SRX1 SGDID:S000001569, Chr XI from 278281-278664, Verified ORF, "Sulfiredoxin, contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes"
>YKL087C CYT2 SGDID:S000001570, Chr XI from 277863-277189, reverse complement, Verified ORF, "Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1"
>YKL088W CAB3 SGDID:S000001571, Chr XI from 275283-276998, Verified ORF, "Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC"
>YKL089W MIF2 SGDID:S000001572, Chr XI from 273394-275043, Verified ORF, "Kinetochore protein with homology to human CENP-C, required for structural integrity of the spindle during anaphase spindle elongation, interacts with histones H2A, H2B, and H4, phosphorylated by Ipl1p"
>YKL090W CUE2 SGDID:S000001573, Chr XI from 271878-273209, Verified ORF, "Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination"
>YKL091C YKL091C SGDID:S000001574, Chr XI from 270650-269718, reverse complement, Verified ORF, "Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus"
>YKL092C BUD2 SGDID:S000001575, Chr XI from 269459-266145, reverse complement, Verified ORF, "GTPase activating factor for Rsr1p/Bud1p required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types"
>YKL093W MBR1 SGDID:S000001576, Chr XI from 264789-265808, Verified ORF, "Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants"
>YKL094W YJU3 SGDID:S000001577, Chr XI from 263349-264290, Verified ORF, "Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family"
>YKL095W YJU2 SGDID:S000001578, Chr XI from 262277-263113, Verified ORF, "Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC ("nineteen complex") and acts after Prp2p to promote the first catalytic reaction of splicing"
>YKL096C-B YKL096C-B SGDID:S000028667, Chr XI from 259222-259073, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YKL096W CWP1 SGDID:S000001579, Chr XI from 261132-261851, Verified ORF, "Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance"
>YKL096W-A CWP2 SGDID:S000001956, Chr XI from 259253-259531, Verified ORF, "Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored"
>YKL097C YKL097C SGDID:S000001580, Chr XI from 258913-258503, reverse complement, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species"
>YKL098W MTC2 SGDID:S000001581, Chr XI from 256770-257843, Verified ORF, "Protein of unknown function; mtc2 is synthetically sick with cdc13-1"
>YKL099C UTP11 SGDID:S000001582, Chr XI from 256472-255720, reverse complement, Verified ORF, "Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit"
>YKL100C YKL100C SGDID:S000001583, Chr XI from 255460-253697, reverse complement, Uncharacterized ORF, "Putative protein of unknown function with similarity to a human minor histocompatibility antigen and signal peptide peptidases; YKL100C is not an essential gene"
>YKL100W-A YKL100W-A SGDID:S000028840, Chr XI from 254159-254248, Dubious ORF, "Putative protein of unknown function; identified by expression profiling and mass spectrometry"
>YKL101W HSL1 SGDID:S000001584, Chr XI from 248920-253476, Verified ORF, "Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p"
>YKL102C YKL102C SGDID:S000001585, Chr XI from 248367-248062, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site"
>YKL103C LAP4 SGDID:S000001586, Chr XI from 247682-246138, reverse complement, Verified ORF, "Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway"
>YKL104C GFA1 SGDID:S000001587, Chr XI from 245373-243220, reverse complement, Verified ORF, "Glutamine-fructose-6-phosphate amidotransferase, catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis"
>YKL105C YKL105C SGDID:S000001588, Chr XI from 242583-239185, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YKL106C-A YKL106C-A SGDID:S000007616, Chr XI from 237266-237147, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi"
>YKL106W AAT1 SGDID:S000001589, Chr XI from 237536-238891, Verified ORF, "Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis"
>YKL107W YKL107W SGDID:S000001590, Chr XI from 236141-237070, Uncharacterized ORF, "Putative protein of unknown function; proposed to be a palmitoylated membrane protein"
>YKL108W SLD2 SGDID:S000001591, Chr XI from 234426-235787, Verified ORF, "Protein required for DNA replication, phosphorylated in S phase by S-phase cyclin-dependent kinases (Cdks), phosphorylation is essential for DNA replication and for complex formation with Dpb11p; potential Cdc28p substrate"
>YKL109W HAP4 SGDID:S000001592, Chr XI from 232227-233891, Verified ORF, "Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex"
>YKL110C KTI12 SGDID:S000001593, Chr XI from 229880-228939, reverse complement, Verified ORF, "Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p"
>YKL111C YKL111C SGDID:S000001594, Chr XI from 228799-228464, reverse complement, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified essential gene ABF1"
>YKL112W ABF1 SGDID:S000001595, Chr XI from 226570-228765, Verified ORF, "DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair"
>YKL113C RAD27 SGDID:S000001596, Chr XI from 225875-224727, reverse complement, Verified ORF, "5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family"
>YKL114C APN1 SGDID:S000001597, Chr XI from 224455-223352, reverse complement, Verified ORF, "Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine"
>YKL115C YKL115C SGDID:S000001598, Chr XI from 223285-222893, reverse complement, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1"
>YKL116C PRR1 SGDID:S000001599, Chr XI from 222900-221344, reverse complement, Verified ORF, "Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor"
>YKL117W SBA1 SGDID:S000001600, Chr XI from 220324-220974, Verified ORF, "Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins and like p23 can regulate telomerase activity"
>YKL118W YKL118W SGDID:S000001601, Chr XI from 219126-219437, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2"
>YKL119C VPH2 SGDID:S000001602, Chr XI from 219217-218570, reverse complement, Verified ORF, "Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER)"
>YKL120W OAC1 SGDID:S000001603, Chr XI from 217344-218318, Verified ORF, "Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family"
>YKL121W DGR2 SGDID:S000001604, Chr XI from 214142-216700, Uncharacterized ORF, "Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds"
>YKL122C SRP21 SGDID:S000001605, Chr XI from 212998-212495, reverse complement, Verified ORF, "Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm"
>YKL123W YKL123W SGDID:S000001606, Chr XI from 212043-212423, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene SSH4"
>YKL124W SSH4 SGDID:S000001607, Chr XI from 210593-212332, Verified ORF, "Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases"
>YKL125W RRN3 SGDID:S000001608, Chr XI from 208247-210130, Verified ORF, "Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA"
>YKL126W YPK1 SGDID:S000001609, Chr XI from 205707-207749, Verified ORF, "Serine/threonine protein kinase that phosphorylates and downregulates flippase activator Fpk1p; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK"
>YKL127W PGM1 SGDID:S000001610, Chr XI from 203541-205253, Verified ORF, "Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism"
>YKL128C PMU1 SGDID:S000001611, Chr XI from 201771-200884, reverse complement, Verified ORF, "Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant"
>YKL129C MYO3 SGDID:S000001612, Chr XI from 200167-196349, reverse complement, Verified ORF, "One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization"
>YKL130C SHE2 SGDID:S000001613, Chr XI from 196028-195288, reverse complement, Verified ORF, "RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud"
>YKL131W YKL131W SGDID:S000001614, Chr XI from 194478-194999, Dubious ORF, "Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YKL132C RMA1 SGDID:S000001615, Chr XI from 194866-193574, reverse complement, Verified ORF, "Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YKL133C YKL133C SGDID:S000001616, Chr XI from 193070-191679, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; has similarity to Mgr3p, but unlike MGR3, is not required for growth of cells lacking the mitochondrial genome (null mutation does not confer a petite-negative phenotype)"
>YKL134C OCT1 SGDID:S000001617, Chr XI from 191442-189124, reverse complement, Verified ORF, "Mitochondrial intermediate peptidase, cleaves N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis"
>YKL135C APL2 SGDID:S000001618, Chr XI from 188640-186460, reverse complement, Verified ORF, "Beta-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting"
>YKL136W YKL136W SGDID:S000001619, Chr XI from 186416-186814, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C"
>YKL137W CMC1 SGDID:S000001620, Chr XI from 185957-186292, Verified ORF, "Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif"
>YKL138C MRPL31 SGDID:S000001621, Chr XI from 185681-185286, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the large subunit"
>YKL138C-A HSK3 SGDID:S000028421, Chr XI from 185012-184803, reverse complement, Verified ORF, "Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis"
>YKL139W CTK1 SGDID:S000001622, Chr XI from 182958-184544, Verified ORF, "Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity"
>YKL140W TGL1 SGDID:S000001623, Chr XI from 180779-182425, Verified ORF, "Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes"
>YKL141W SDH3 SGDID:S000001624, Chr XI from 179667-180263, Verified ORF, "Cytochrome b subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain"
>YKL142W MRP8 SGDID:S000001625, Chr XI from 178515-179174, Verified ORF, "Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; originally thought to be a mitochondrial ribosomal protein based on sequence analysis"
>YKL143W LTV1 SGDID:S000001626, Chr XI from 176781-178172, Verified ORF, "Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature"
>YKL144C RPC25 SGDID:S000001627, Chr XI from 176481-175843, reverse complement, Verified ORF, "RNA polymerase III subunit C25, required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p"
>YKL145W RPT1 SGDID:S000001628, Chr XI from 174213-175616, Verified ORF, "One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance"
>YKL145W-A YKL145W-A SGDID:S000028841, Chr XI from 174958-175050, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; completely overlaps the verified essential gene RPT1; identified by expression profiling and mass spectrometry"
>YKL146W AVT3 SGDID:S000001629, Chr XI from 171783-173861, Verified ORF, "Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters"
>YKL147C YKL147C SGDID:S000001630, Chr XI from 172168-171551, reverse complement, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3"
>YKL148C SDH1 SGDID:S000001631, Chr XI from 171129-169207, reverse complement, Verified ORF, "Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain"
>YKL149C DBR1 SGDID:S000001632, Chr XI from 168829-167612, reverse complement, Verified ORF, "RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition"
>YKL150W MCR1 SGDID:S000001633, Chr XI from 166544-167452, Verified ORF, "Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis"
>YKL151C YKL151C SGDID:S000001634, Chr XI from 165930-164917, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"
>YKL152C GPM1 SGDID:S000001635, Chr XI from 164385-163642, reverse complement, Verified ORF, "Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis"
>YKL153W YKL153W SGDID:S000001636, Chr XI from 163600-164109, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant"
>YKL154W SRP102 SGDID:S000001637, Chr XI from 161601-162335, Verified ORF, "Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane"
>YKL155C RSM22 SGDID:S000001638, Chr XI from 161342-159456, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase"
>YKL156C-A YKL156C-A SGDID:S000028668, Chr XI from 159091-158975, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein; completely overlaps the verified gene RPS27A; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YKL156W RPS27A SGDID:S000001639, Chr XI from 158613-158615,158967-159212, Verified ORF, "Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Bp and has similarity to rat S27 ribosomal protein"
>YKL157W APE2 SGDID:S000001640, Chr XI from 154991-155271,155655-158232, Verified ORF, "Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; sequence coordinates have changed since RT-PCR analysis showed that the adjacent ORF YKL158W comprises the 5' exon of APE2/YKL157W"
>YKL159C RCN1 SGDID:S000001642, Chr XI from 154451-153816, reverse complement, Verified ORF, "Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region"
>YKL160W ELF1 SGDID:S000001643, Chr XI from 153269-153706, Verified ORF, "Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression"
>YKL161C KDX1 SGDID:S000001644, Chr XI from 150687-149386, reverse complement, Verified ORF, "Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p"
>YKL162C YKL162C SGDID:S000001645, Chr XI from 148838-147630, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion"
>YKL162C-A YKL162C-A SGDID:S000007244, Chr XI from 146074-145922, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YKL163W PIR3 SGDID:S000001646, Chr XI from 144401-145378, Verified ORF, "O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway"
>YKL164C PIR1 SGDID:S000001647, Chr XI from 142819-141794, reverse complement, Verified ORF, "O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle"
>YKL165C MCD4 SGDID:S000001648, Chr XI from 140691-137932, reverse complement, Verified ORF, "Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes"
>YKL165C-A YKL165C-A SGDID:S000007617, Chr XI from 136023-135790, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YKL166C TPK3 SGDID:S000001649, Chr XI from 135705-134509, reverse complement, Verified ORF, "cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase"
>YKL167C MRP49 SGDID:S000001650, Chr XI from 134134-133721, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation"
>YKL168C KKQ8 SGDID:S000001651, Chr XI from 133462-131288, reverse complement, Verified ORF, "Putative serine/threonine protein kinase with unknown cellular role"
>YKL169C YKL169C SGDID:S000001652, Chr XI from 131068-130685, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL38"
>YKL170W MRPL38 SGDID:S000001653, Chr XI from 130634-131050, Verified ORF, "Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels"
>YKL171W NNK1 SGDID:S000001654, Chr XI from 127475-130261, Verified ORF, "Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm"
>YKL172W EBP2 SGDID:S000001655, Chr XI from 125759-127042, Verified ORF, "Essential protein required for the maturation of 25S rRNA and 60S ribosomal subunit assembly, localizes to the nucleolus; constituent of 66S pre-ribosomal particles"
>YKL173W SNU114 SGDID:S000001656, Chr XI from 122517-125543, Verified ORF, "GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2"
>YKL174C TPO5 SGDID:S000001657, Chr XI from 122236-120380, reverse complement, Verified ORF, "Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles"
>YKL175W ZRT3 SGDID:S000001658, Chr XI from 118793-120304, Verified ORF, "Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency"
>YKL176C LST4 SGDID:S000001659, Chr XI from 117986-115500, reverse complement, Verified ORF, "Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface"
>YKL177W YKL177W SGDID:S000001660, Chr XI from 114356-114694, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene STE3"
>YKL178C STE3 SGDID:S000001661, Chr XI from 114627-113215, reverse complement, Verified ORF, "Receptor for a factor pheromone, couples to MAP kinase cascade to mediate pheromone response; transcribed in alpha cells and required for mating by alpha cells, ligand bound receptors endocytosed and recycled to the plasma membrane; GPCR"
>YKL179C COY1 SGDID:S000001662, Chr XI from 112503-110464, reverse complement, Verified ORF, "Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function"
>YKL180W RPL17A SGDID:S000001663, Chr XI from 109269-109577,109884-110129, Verified ORF, "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Bp and has similarity to E. coli L22 and rat L17 ribosomal proteins; copurifies with the Dam1 complex (aka DASH complex)"
>YKL181W PRS1 SGDID:S000001664, Chr XI from 107316-108599, Verified ORF, "5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes"
>YKL182W FAS1 SGDID:S000001665, Chr XI from 100671-106826, Verified ORF, "Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities"
>YKL183C-A YKL183C-A SGDID:S000028558, Chr XI from 98607-98395, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by fungal homology and RT-PCR"
>YKL183W LOT5 SGDID:S000001666, Chr XI from 98721-99641, Verified ORF, "Protein of unknown function; gene expression increases in cultures shifted to a lower temperature"
>YKL184W SPE1 SGDID:S000001667, Chr XI from 96757-98157, Verified ORF, "Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation"
>YKL185W ASH1 SGDID:S000001668, Chr XI from 94499-96265, Verified ORF, "Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate"
>YKL186C MTR2 SGDID:S000001669, Chr XI from 93298-92744, reverse complement, Verified ORF, "mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA"
>YKL187C YKL187C SGDID:S000001670, Chr XI from 91536-89284, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies"
>YKL188C PXA2 SGDID:S000001671, Chr XI from 88786-86225, reverse complement, Verified ORF, "Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins"
>YKL189W HYM1 SGDID:S000001672, Chr XI from 84704-85903, Verified ORF, "Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response"
>YKL190W CNB1 SGDID:S000001673, Chr XI from 82947-82998,83075-83550, Verified ORF, "Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1"
>YKL191W DPH2 SGDID:S000001674, Chr XI from 81035-82639, Verified ORF, "Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p"
>YKL192C ACP1 SGDID:S000001675, Chr XI from 80537-80160, reverse complement, Verified ORF, "Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p"
>YKL193C SDS22 SGDID:S000001676, Chr XI from 79882-78866, reverse complement, Verified ORF, "Conserved nuclear regulatory subunit of Glc7p type 1 protein serine-threonine phosphatase (PP1), functions positively with Glc7p to promote dephosphorylation of nuclear substrates required for chromosome transmission during mitosis"
>YKL194C MST1 SGDID:S000001677, Chr XI from 78646-77258, reverse complement, Verified ORF, "Mitochondrial threonyl-tRNA synthetase"
>YKL195W MIA40 SGDID:S000001678, Chr XI from 75821-77032, Verified ORF, "Essential protein of the mitochondrial intermembrane space (IMS); promotes retention of newly imported proteins; may do so by stabilizing client protein folding as part of a disulfide relay system or transferring metal to client proteins"
>YKL196C YKT6 SGDID:S000001679, Chr XI from 75534-74932, reverse complement, Verified ORF, "Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus"
>YKL197C PEX1 SGDID:S000001680, Chr XI from 73865-70734, reverse complement, Verified ORF, "AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis"
>YKL198C PTK1 SGDID:S000001681, Chr XI from 70220-68232, reverse complement, Verified ORF, "Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein"
>YKL201C MNN4 SGDID:S000001684, Chr XI from 67466-63930, reverse complement, Verified ORF, "Putative positive regulator of mannosylphosphate transferase (Mnn6p), involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases"
>YKL202W YKL202W SGDID:S000001685, Chr XI from 63821-64402, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YKL203C TOR2 SGDID:S000001686, Chr XI from 63359-55935, reverse complement, Verified ORF, "PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis"
>YKL204W EAP1 SGDID:S000001687, Chr XI from 53704-55602, Verified ORF, "eIF4E-associated protein, competes with eIF4G for binding to eIF4E; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade"
>YKL205W LOS1 SGDID:S000001688, Chr XI from 50051-53353, Verified ORF, "Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm"
>YKL206C ADD66 SGDID:S000001689, Chr XI from 49809-49006, reverse complement, Verified ORF, "Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly"
>YKL207W AIM27 SGDID:S000001690, Chr XI from 48194-48955, Verified ORF, "Member of a transmembrane complex required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response"
>YKL208W CBT1 SGDID:S000001691, Chr XI from 47157-47972, Verified ORF, "Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p"
>YKL209C STE6 SGDID:S000001692, Chr XI from 46295-42423, reverse complement, Verified ORF, "Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells"
>YKL210W UBA1 SGDID:S000001693, Chr XI from 39163-42237, Verified ORF, "Ubiquitin activating enzyme (E1), involved in ubiquitin-mediated protein degradation and essential for viability"
>YKL211C TRP3 SGDID:S000001694, Chr XI from 38153-36699, reverse complement, Verified ORF, "Bifunctional enzyme exhibiting both indole-3-glycerol-phosphate synthase and anthranilate synthase activities, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p"
>YKL212W SAC1 SGDID:S000001695, Chr XI from 34543-36414, Verified ORF, "Phosphatidylinositol phosphate (PtdInsP) phosphatase involved in hydrolysis of PtdIns[4]P; transmembrane protein localizes to ER and Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance"
>YKL213C DOA1 SGDID:S000001696, Chr XI from 34107-31960, reverse complement, Verified ORF, "WD repeat protein required for ubiquitin-mediated protein degradation, forms complex with Cdc48p, plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase"
>YKL214C YRA2 SGDID:S000001697, Chr XI from 31693-31082, reverse complement, Verified ORF, "Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus"
>YKL215C OXP1 SGDID:S000001698, Chr XI from 30687-26827, reverse complement, Verified ORF, "5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"
>YKL216W URA1 SGDID:S000001699, Chr XI from 25215-26159, Verified ORF, "Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid"
>YKL217W JEN1 SGDID:S000001700, Chr XI from 22234-24084, Verified ORF, "Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose"
>YKL218C SRY1 SGDID:S000001701, Chr XI from 18339-17359, reverse complement, Verified ORF, "3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity"
>YKL219W COS9 SGDID:S000001702, Chr XI from 14485-15708, Verified ORF, "Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins"
>YKL220C FRE2 SGDID:S000001703, Chr XI from 11226-9091, reverse complement, Verified ORF, "Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels"
>YKL221W MCH2 SGDID:S000001704, Chr XI from 6107-7528, Verified ORF, "Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport"
>YKL222C YKL222C SGDID:S000001705, Chr XI from 5620-3503, reverse complement, Verified ORF, "Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine"
>YKL223W YKL223W SGDID:S000001706, Chr XI from 2389-2721, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YKL224C PAU16 SGDID:S000001707, Chr XI from 2181-1810, reverse complement, Verified ORF, "Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions"
>YKL225W YKL225W SGDID:S000001708, Chr XI from 451-798, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YKR001C VPS1 SGDID:S000001709, Chr XI from 442722-440608, reverse complement, Verified ORF, "Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis"
>YKR002W PAP1 SGDID:S000001710, Chr XI from 443232-444938, Verified ORF, "Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs"
>YKR003W OSH6 SGDID:S000001711, Chr XI from 445381-446727, Verified ORF, "Member of an oxysterol-binding protein family with overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery"
>YKR004C ECM9 SGDID:S000001712, Chr XI from 447706-446799,448036-447811, reverse complement, Verified ORF, "Non-essential protein of unknown function"
>YKR005C YKR005C SGDID:S000001713, Chr XI from 449951-448521,450167-450021, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YKR006C MRPL13 SGDID:S000001714, Chr XI from 451217-450423, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation"
>YKR007W MEH1 SGDID:S000001715, Chr XI from 451434-451988, Verified ORF, "Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification"
>YKR008W RSC4 SGDID:S000001716, Chr XI from 452201-454078, Verified ORF, "Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling"
>YKR009C FOX2 SGDID:S000001717, Chr XI from 457054-454352, reverse complement, Verified ORF, "Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities"
>YKR010C TOF2 SGDID:S000001718, Chr XI from 461239-458924, reverse complement, Verified ORF, "Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site"
>YKR011C YKR011C SGDID:S000001719, Chr XI from 462696-461635, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus"
>YKR012C YKR012C SGDID:S000001720, Chr XI from 464116-463739, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2"
>YKR013W PRY2 SGDID:S000001721, Chr XI from 463959-464948, Verified ORF, "Protein of unknown function"
>YKR014C YPT52 SGDID:S000001722, Chr XI from 466071-465367, reverse complement, Verified ORF, "Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis"
>YKR015C YKR015C SGDID:S000001723, Chr XI from 468667-466961, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YKR016W FCJ1 SGDID:S000001724, Chr XI from 469717-471339, Verified ORF, "Mitochondrial inner membrane protein involved in formation and molecular structure of crista junctions; impairs oligomerization of F1F0-ATP synthase; null shows altered mitochondrial morphology and abnormal mitochondrial genome maintenance"
>YKR017C YKR017C SGDID:S000001725, Chr XI from 473349-471694, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; contains a RING finger motif"
>YKR018C YKR018C SGDID:S000001726, Chr XI from 475900-473723, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus"
>YKR019C IRS4 SGDID:S000001727, Chr XI from 478063-476216, reverse complement, Verified ORF, "EH domain-containing protein involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS"
>YKR020W VPS51 SGDID:S000001728, Chr XI from 478338-478832, Verified ORF, "Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p"
>YKR021W ALY1 SGDID:S000001729, Chr XI from 479234-481981, Verified ORF, "Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"
>YKR022C NTR2 SGDID:S000001730, Chr XI from 483139-482171, reverse complement, Verified ORF, "Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly"
>YKR023W YKR023W SGDID:S000001731, Chr XI from 483419-485011, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YKR024C DBP7 SGDID:S000001732, Chr XI from 487372-485144, reverse complement, Verified ORF, "Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; essential for growth under anaerobic conditions"
>YKR025W RPC37 SGDID:S000001733, Chr XI from 487770-488618, Verified ORF, "RNA polymerase III subunit C37"
>YKR026C GCN3 SGDID:S000001734, Chr XI from 489655-488738, reverse complement, Verified ORF, "Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression"
>YKR027W BCH2 SGDID:S000001735, Chr XI from 491364-493661, Verified ORF, "Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane"
>YKR028W SAP190 SGDID:S000001736, Chr XI from 494257-497358, Verified ORF, "Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p"
>YKR029C SET3 SGDID:S000001737, Chr XI from 499833-497578, reverse complement, Verified ORF, "Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains"
>YKR030W GMH1 SGDID:S000001738, Chr XI from 500282-501103, Verified ORF, "Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting"
>YKR031C SPO14 SGDID:S000001739, Chr XI from 506395-501344, reverse complement, Verified ORF, "Phospholipase D, catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis"
>YKR032W YKR032W SGDID:S000001740, Chr XI from 506517-506831, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YKR033C YKR033C SGDID:S000001741, Chr XI from 507304-506879, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80"
>YKR034W DAL80 SGDID:S000001742, Chr XI from 506898-507707, Verified ORF, "Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Deh1p"
>YKR035C OPI8 SGDID:S000001743, Chr XI from 508561-507920, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene DID2/YKR035W-A"
>YKR035W-A DID2 SGDID:S000006435, Chr XI from 507939-508553, Verified ORF, "Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors"
>YKR036C CAF4 SGDID:S000001744, Chr XI from 510633-508702, reverse complement, Verified ORF, "WD40 repeat-containing protein associated with the CCR4-NOT complex, interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission"
>YKR037C SPC34 SGDID:S000001745, Chr XI from 511797-510910, reverse complement, Verified ORF, "Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body"
>YKR038C KAE1 SGDID:S000001746, Chr XI from 513159-511999, reverse complement, Verified ORF, "Highly conserved putative glycoprotease proposed to be involved in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex"
>YKR039W GAP1 SGDID:S000001747, Chr XI from 515063-516871, Verified ORF, "General amino acid permease; localization to the plasma membrane is regulated by nitrogen source"
>YKR040C YKR040C SGDID:S000001748, Chr XI from 518566-518063, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W"
>YKR041W YKR041W SGDID:S000001749, Chr XI from 518198-518950, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus"
>YKR042W UTH1 SGDID:S000001750, Chr XI from 519527-520624, Verified ORF, "Mitochondrial outer membrane and cell wall localized SUN family member involved in cell wall biogenesis and required for mitochondrial autophagy; involved in the oxidative stress response, life span during starvation, and cell death"
>YKR043C YKR043C SGDID:S000001751, Chr XI from 521712-520897, reverse complement, Verified ORF, "Metal-independent fructose 1,6-bisphosphatase, may play a role in gluconeogenesis under metal-limiting conditions; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus"
>YKR044W UIP5 SGDID:S000001752, Chr XI from 522015-523346, Verified ORF, "Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates"
>YKR045C YKR045C SGDID:S000001753, Chr XI from 523969-523418, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm"
>YKR046C PET10 SGDID:S000001754, Chr XI from 525074-524223, reverse complement, Verified ORF, "Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange"
>YKR047W YKR047W SGDID:S000001755, Chr XI from 525257-525562, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1"
>YKR048C NAP1 SGDID:S000001756, Chr XI from 526640-525387, reverse complement, Verified ORF, "Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2"
>YKR049C FMP46 SGDID:S000001757, Chr XI from 527231-526830, reverse complement, Verified ORF, "Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YKR050W TRK2 SGDID:S000001758, Chr XI from 527815-530484, Verified ORF, "Component of the Trk1p-Trk2p potassium transport system"
>YKR051W YKR051W SGDID:S000001759, Chr XI from 530946-532202, Uncharacterized ORF, "Putative protein of unknown function"
>YKR052C MRS4 SGDID:S000001760, Chr XI from 533464-532550, reverse complement, Verified ORF, "Iron transporter that mediates Fe2+ transport across the inner mitochondrial membrane; mitochondrial carrier family member, similar to and functionally redundant with Mrs3p; active under low-iron conditions; may transport other cations"
>YKR053C YSR3 SGDID:S000001761, Chr XI from 535281-534067, reverse complement, Verified ORF, "Dihydrosphingosine 1-phosphate phosphatase, membrane protein involved in sphingolipid metabolism; has similarity to Lcb3p"
>YKR054C DYN1 SGDID:S000001762, Chr XI from 547925-535647, reverse complement, Verified ORF, "Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p"
>YKR055W RHO4 SGDID:S000001763, Chr XI from 548216-549091, Verified ORF, "Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity"
>YKR056W TRM2 SGDID:S000001764, Chr XI from 549448-551367, Verified ORF, "tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair"
>YKR057W RPS21A SGDID:S000001765, Chr XI from 551657-551680,552003-552242, Verified ORF, "Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Bp and has similarity to rat S21 ribosomal protein"
>YKR058W GLG1 SGDID:S000001766, Chr XI from 552770-554620, Verified ORF, "Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin"
>YKR059W TIF1 SGDID:S000001767, Chr XI from 554987-556174, Verified ORF, "Translation initiation factor eIF4A, identical to Tif2p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G"
>YKR060W UTP30 SGDID:S000001768, Chr XI from 556518-557342, Verified ORF, "Subunit of U3-containing 90S preribosome complex involved in production of 18S rRNA and assembly of small ribosomal subunit"
>YKR061W KTR2 SGDID:S000001769, Chr XI from 557677-558954, Verified ORF, "Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family"
>YKR062W TFA2 SGDID:S000001770, Chr XI from 559666-560652, Verified ORF, "TFIIE small subunit, involved in RNA polymerase II transcription initiation"
>YKR063C LAS1 SGDID:S000001771, Chr XI from 562297-560789, reverse complement, Verified ORF, "Essential nuclear protein possibly involved in bud formation and morphogenesis; mutants require the SSD1-v allele for viability"
>YKR064W OAF3 SGDID:S000001772, Chr XI from 562547-565138, Verified ORF, "Zinc cluster protein; regulates transcription in response to oleate levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YKR065C PAM17 SGDID:S000001773, Chr XI from 565892-565299, reverse complement, Verified ORF, "Constituent of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 complex"
>YKR066C CCP1 SGDID:S000001774, Chr XI from 567198-566113, reverse complement, Verified ORF, "Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress"
>YKR067W GPT2 SGDID:S000001775, Chr XI from 567918-570149, Verified ORF, "Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis"
>YKR068C BET3 SGDID:S000001776, Chr XI from 570909-570328, reverse complement, Verified ORF, "Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex"
>YKR069W MET1 SGDID:S000001777, Chr XI from 571612-573393, Verified ORF, "S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis"
>YKR070W YKR070W SGDID:S000001778, Chr XI from 573574-574632, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YKR071C DRE2 SGDID:S000001779, Chr XI from 575980-574934, reverse complement, Verified ORF, "Conserved component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18p; ortholog of human Ciapin1"
>YKR072C SIS2 SGDID:S000001780, Chr XI from 578123-576435, reverse complement, Verified ORF, "Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis"
>YKR073C YKR073C SGDID:S000001781, Chr XI from 578507-578187, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YKR074W AIM29 SGDID:S000001782, Chr XI from 579209-579676, Verified ORF, "Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss"
>YKR075C YKR075C SGDID:S000001783, Chr XI from 580750-579827, reverse complement, Uncharacterized ORF, "Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS"
>YKR075W-A YKR075W-A SGDID:S000028669, Chr XI from 580212-580481, Dubious ORF, "Dubious open reading frame unlikely to encode a protein; completely overlaps the uncharacterized gene YKR075W; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YKR076W ECM4 SGDID:S000001784, Chr XI from 582283-583395, Verified ORF, "Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"
>YKR077W MSA2 SGDID:S000001785, Chr XI from 583653-584744, Verified ORF, "Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation"
>YKR078W YKR078W SGDID:S000001786, Chr XI from 584952-586709, Verified ORF, "Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)"
>YKR079C TRZ1 SGDID:S000001787, Chr XI from 589305-586789, reverse complement, Verified ORF, "tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2"
>YKR080W MTD1 SGDID:S000001788, Chr XI from 590395-591357, Verified ORF, "NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline"
>YKR081C RPF2 SGDID:S000001789, Chr XI from 592540-591506, reverse complement, Verified ORF, "Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles"
>YKR082W NUP133 SGDID:S000001790, Chr XI from 592825-596298, Verified ORF, "Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), localizes to both sides of the NPC, required to establish a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p"
>YKR083C DAD2 SGDID:S000001791, Chr XI from 596822-596421, reverse complement, Verified ORF, "Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis"
>YKR084C HBS1 SGDID:S000001792, Chr XI from 598890-597055, reverse complement, Verified ORF, "GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled; genetically implicated in mRNA no-go decay"
>YKR085C MRPL20 SGDID:S000001793, Chr XI from 599681-599094, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the large subunit"
>YKR086W PRP16 SGDID:S000001794, Chr XI from 599857-603072, Verified ORF, "RNA helicase in the DEAH-box family involved in the second catalytic step of splicing, exhibits ATP-dependent RNA unwinding activity"
>YKR087C OMA1 SGDID:S000001795, Chr XI from 604232-603195, reverse complement, Verified ORF, "Metalloendopeptidase of the mitochondrial inner membrane, involved in turnover of membrane-embedded proteins; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes"
>YKR088C TVP38 SGDID:S000001796, Chr XI from 605418-604405, reverse complement, Verified ORF, "Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern"
>YKR089C TGL4 SGDID:S000001797, Chr XI from 608365-605633, reverse complement, Verified ORF, "Multifunctional triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p"
>YKR090W PXL1 SGDID:S000001798, Chr XI from 608946-611066, Verified ORF, "LIM domain-containing protein that localizes to sites of polarized growth, required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; has similarity to metazoan paxillin"
>YKR091W SRL3 SGDID:S000001799, Chr XI from 611525-612265, Verified ORF, "Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate"
>YKR092C SRP40 SGDID:S000001800, Chr XI from 613885-612665, reverse complement, Verified ORF, "Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140"
>YKR093W PTR2 SGDID:S000001801, Chr XI from 615730-617535, Verified ORF, "Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p"
>YKR094C RPL40B SGDID:S000001802, Chr XI from 618374-617996,618750-618743, reverse complement, Verified ORF, "Fusion protein, identical to Rpl40Ap, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes"
>YKR095W MLP1 SGDID:S000001803, Chr XI from 619805-625432, Verified ORF, "Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs"
>YKR095W-A PCC1 SGDID:S000028512, Chr XI from 625864-625901,625977-626205, Verified ORF, "Proposed transcription factor involved in the expression of genes regulated by alpha-factor and galactose; component of the EKC/KEOPS protein complex with Kae1p, Gon7p, Bud32p, and Cgi121p; related to human cancer-testis antigens"
>YKR096W YKR096W SGDID:S000001804, Chr XI from 626793-630380, Verified ORF, "Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc domain"
>YKR097W PCK1 SGDID:S000001805, Chr XI from 631152-632801, Verified ORF, "Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol"
>YKR098C UBP11 SGDID:S000001806, Chr XI from 635179-633026, reverse complement, Verified ORF, "Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins"
>YKR099W BAS1 SGDID:S000001807, Chr XI from 635851-638286, Verified ORF, "Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes"
>YKR100C SKG1 SGDID:S000001808, Chr XI from 639968-638901, reverse complement, Verified ORF, "Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell"
>YKR101W SIR1 SGDID:S000001809, Chr XI from 640540-642504, Verified ORF, "Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin"
>YKR102W FLO10 SGDID:S000001810, Chr XI from 646356-649865, Verified ORF, "Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation"
>YKR103W NFT1 SGDID:S000001811, Chr XI from 653080-656736, Verified ORF, "Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds."
>YKR104W YKR104W SGDID:S000001812, Chr XI from 656836-657756, Verified ORF, "Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds"
>YKR105C VBA5 SGDID:S000001813, Chr XI from 660464-658716, reverse complement, Uncharacterized ORF, "Putative transporter of the Major Facilitator Superfamily (MFS); proposed role as a basic amino acid permease based on phylogeny"
>YKR106W YKR106W SGDID:S000001814, Chr XI from 661442-663289, Uncharacterized ORF, "Protein of unconfirmed function; displays a topology characteristic of the Major Facilitators Superfamily of membrane proteins; coding sequence 98% identical to that of YCL073C"
>YLL001W DNM1 SGDID:S000003924, Chr XII from 147890-150163, Verified ORF, "Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance"
>YLL002W RTT109 SGDID:S000003925, Chr XII from 146291-147601, Verified ORF, "Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p"
>YLL003W SFI1 SGDID:S000003926, Chr XII from 143201-146041, Verified ORF, "Centrin (Cdc31p)-binding protein required for spindle pole body (SPB) duplication, localizes to the half-bridge of the SPB, required for progression through G(2)-M transition, has similarity to Xenopus laevis XCAP-C"
>YLL004W ORC3 SGDID:S000003927, Chr XII from 141073-142923, Verified ORF, "Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing"
>YLL005C SPO75 SGDID:S000003928, Chr XII from 140546-137940, reverse complement, Verified ORF, "Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis"
>YLL006W MMM1 SGDID:S000003929, Chr XII from 136586-137866, Verified ORF, "ER integral membrane protein, component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth"
>YLL006W-A YLL006W-A SGDID:S000028560, Chr XII from 136345-136521, Uncharacterized ORF, "Putative protein of unknown function; identified by fungal homology and RT-PCR"
>YLL007C YLL007C SGDID:S000003930, Chr XII from 136299-134302, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL007C is not an essential gene"
>YLL008W DRS1 SGDID:S000003931, Chr XII from 131729-133987, Verified ORF, "Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles"
>YLL009C COX17 SGDID:S000003932, Chr XII from 131414-131205, reverse complement, Verified ORF, "Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs"
>YLL010C PSR1 SGDID:S000003933, Chr XII from 130613-129330, reverse complement, Verified ORF, "Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p"
>YLL011W SOF1 SGDID:S000003934, Chr XII from 127523-128992, Verified ORF, "Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p"
>YLL012W YEH1 SGDID:S000003935, Chr XII from 125534-127255, Verified ORF, "Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes"
>YLL013C PUF3 SGDID:S000003936, Chr XII from 124714-122075, reverse complement, Verified ORF, "Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins"
>YLL014W EMC6 SGDID:S000003937, Chr XII from 121322-121648, Verified ORF, "Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response"
>YLL015W BPT1 SGDID:S000003938, Chr XII from 116432-121111, Verified ORF, "ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p"
>YLL016W SDC25 SGDID:S000003939, Chr XII from 112847-115993, pseudogene, "Non-essential Ras guanine nucleotide exchange factor (GEF) localized to the membrane; expressed in poor nutrients and on non-fermentable carbon sources; homologous to CDC25; contains a stop codon in S288C; full-length gene includes YLL017W"
>YLL017W YLL017W SGDID:S000003940, Chr XII from 112234-112545, pseudogene, "Non-essential Ras guanine nucleotide exchange factor (GEF) localized to the membrane; expressed in poor nutrients and on non-fermentable carbon sources; homologous to CDC25; contains a stop codon in S288C; full-length gene includes YLL016W"
>YLL018C DPS1 SGDID:S000003941, Chr XII from 111575-109902, reverse complement, Verified ORF, "Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation"
>YLL018C-A COX19 SGDID:S000007245, Chr XII from 108972-108676, reverse complement, Verified ORF, "Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs"
>YLL019C KNS1 SGDID:S000003942, Chr XII from 107899-105686, reverse complement, Verified ORF, "Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues"
>YLL019W-A YLL019W-A SGDID:S000028670, Chr XII from 106908-107000, Dubious ORF, "Dubious open reading frame unlikely to encode a protein; completely overlaps the verified gene KNS1"
>YLL020C YLL020C SGDID:S000003943, Chr XII from 105861-105556, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1"
>YLL021W SPA2 SGDID:S000003944, Chr XII from 100947-105347, Verified ORF, "Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate"
>YLL022C HIF1 SGDID:S000003945, Chr XII from 100201-99044, reverse complement, Verified ORF, "Non-essential component of the HAT-B histone acetyltransferase complex (Hat1p-Hat2p-Hif1p), localized to the nucleus; has a role in telomeric silencing"
>YLL023C POM33 SGDID:S000003946, Chr XII from 98836-97997, reverse complement, Verified ORF, "Transmembrane nucleoporin involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p"
>YLL024C SSA2 SGDID:S000003947, Chr XII from 97485-95566, reverse complement, Verified ORF, "ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall"
>YLL025W PAU17 SGDID:S000003948, Chr XII from 94747-95121, Verified ORF, "Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; YLL025W is not an essential gene"
>YLL026W HSP104 SGDID:S000003949, Chr XII from 88623-91349, Verified ORF, "Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation"
>YLL027W ISA1 SGDID:S000003950, Chr XII from 87403-88155, Verified ORF, "Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins, isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources"
>YLL028W TPO1 SGDID:S000003951, Chr XII from 84804-86564, Verified ORF, "Polyamine transporter that recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane"
>YLL029W FRA1 SGDID:S000003952, Chr XII from 81461-83710, Verified ORF, "Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation"
>YLL030C RRT7 SGDID:S000003953, Chr XII from 80697-80356, reverse complement, Dubious ORF, "Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YLL031C GPI13 SGDID:S000003954, Chr XII from 80205-77152, reverse complement, Verified ORF, "ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein"
>YLL032C YLL032C SGDID:S000003955, Chr XII from 76747-74270, reverse complement, Verified ORF, "Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene"
>YLL033W IRC19 SGDID:S000003956, Chr XII from 73409-74101, Verified ORF, "Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci"
>YLL034C RIX7 SGDID:S000003957, Chr XII from 73146-70633, reverse complement, Verified ORF, "Putative ATPase of the AAA family, required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions"
>YLL035W GRC3 SGDID:S000003958, Chr XII from 68580-70478, Verified ORF, "Polynucleotide kinase present on rDNA that is required for efficient transcription termination by RNA polymerase I; required for cell growth; mRNA is cell-cycle regulated"
>YLL036C PRP19 SGDID:S000003959, Chr XII from 68256-66745, reverse complement, Verified ORF, "Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases"
>YLL037W YLL037W SGDID:S000003960, Chr XII from 66562-66942, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential PRP19 gene encoding an RNA splicing factor"
>YLL038C ENT4 SGDID:S000003961, Chr XII from 66518-65775, reverse complement, Verified ORF, "Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome"
>YLL039C UBI4 SGDID:S000003962, Chr XII from 65207-64062, reverse complement, Verified ORF, "Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats"
>YLL040C VPS13 SGDID:S000003963, Chr XII from 63645-54211, reverse complement, Verified ORF, "Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; homologous to human COH1; involved in sporulation, vacuolar protein sorting and protein-Golgi retention"
>YLL041C SDH2 SGDID:S000003964, Chr XII from 53931-53131, reverse complement, Verified ORF, "Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain"
>YLL042C ATG10 SGDID:S000003965, Chr XII from 52590-52087, reverse complement, Verified ORF, "Conserved E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy"
>YLL043W FPS1 SGDID:S000003966, Chr XII from 49938-51947, Verified ORF, "Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress"
>YLL044W YLL044W SGDID:S000003967, Chr XII from 48216-48662, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant"
>YLL045C RPL8B SGDID:S000003968, Chr XII from 48629-47859, reverse complement, Verified ORF, "Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits"
>YLL046C RNP1 SGDID:S000003969, Chr XII from 47463-46714, reverse complement, Verified ORF, "Ribonucleoprotein that contains two RNA recognition motifs (RRM)"
>YLL047W YLL047W SGDID:S000003970, Chr XII from 46672-47055, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1"
>YLL048C YBT1 SGDID:S000003971, Chr XII from 46265-41280, reverse complement, Verified ORF, "Transporter of the ATP-binding cassette (ABC) family involved in bile acid transport; similar to mammalian bile transporters"
>YLL049W LDB18 SGDID:S000003972, Chr XII from 40666-41205, Verified ORF, "Component of the dynactin complex, which is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24"
>YLL050C COF1 SGDID:S000003973, Chr XII from 40221-39804,40414-40401, reverse complement, Verified ORF, "Cofilin, promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers and filaments and severs filaments; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes"
>YLL051C FRE6 SGDID:S000003974, Chr XII from 39471-37333, reverse complement, Verified ORF, "Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels"
>YLL052C AQY2 SGDID:S000003975, Chr XII from 36361-35912, reverse complement, Verified ORF, "Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains"
>YLL053C YLL053C SGDID:S000003976, Chr XII from 35961-35503, reverse complement, Uncharacterized ORF, "Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin"
>YLL054C YLL054C SGDID:S000003977, Chr XII from 35204-32673, reverse complement, Uncharacterized ORF, "Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene"
>YLL055W YCT1 SGDID:S000003978, Chr XII from 30109-31704, Verified ORF, "High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene"
>YLL056C YLL056C SGDID:S000003979, Chr XII from 28305-27409, reverse complement, Uncharacterized ORF, "Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin"
>YLL057C JLP1 SGDID:S000003980, Chr XII from 26994-25756, reverse complement, Verified ORF, "Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation"
>YLL058W YLL058W SGDID:S000003981, Chr XII from 23569-25296, Uncharacterized ORF, "Putative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene"
>YLL059C YLL059C SGDID:S000003982, Chr XII from 22980-22474, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YLL060C GTT2 SGDID:S000003983, Chr XII from 21839-21138, reverse complement, Verified ORF, "Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p"
>YLL061W MMP1 SGDID:S000003984, Chr XII from 17956-19707, Verified ORF, "High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p"
>YLL062C MHT1 SGDID:S000003985, Chr XII from 17613-16639, reverse complement, Verified ORF, "S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio"
>YLL063C AYT1 SGDID:S000003986, Chr XII from 16072-14648, reverse complement, Verified ORF, "Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis"
>YLL064C PAU18 SGDID:S000003987, Chr XII from 13445-13083, reverse complement, Verified ORF, "Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau6p"
>YLL065W YLL065W SGDID:S000003988, Chr XII from 11726-12076, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps chromosome XII telomeric element core sequences"
>YLL066C YLL066C SGDID:S000003989, Chr XII from 9450-6120,9836-9550, reverse complement, Uncharacterized ORF, "Putative protein of unknown function with similarity to helicases; YLL066C is not an essential gene"
>YLL066W-A YLL066W-A SGDID:S000028671, Chr XII from 6486-6968, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized ORF YLL066C"
>YLL066W-B YLL066W-B SGDID:S000028672, Chr XII from 5605-5775, Uncharacterized ORF, "Putative protein of unknown function; overexpression causes a cell cycle delay or arrest"
>YLL067C YLL067C SGDID:S000003990, Chr XII from 3915-585,4301-4015, reverse complement, Uncharacterized ORF, "Putative protein of unknown function with similarity to helicases"
>YLL067W-A YLL067W-A SGDID:S000028673, Chr XII from 843-1325, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps YLL067C"
>YLR001C YLR001C SGDID:S000003991, Chr XII from 153977-151389, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted to be palmitoylated"
>YLR002C NOC3 SGDID:S000003992, Chr XII from 156334-154343, reverse complement, Verified ORF, "Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport; also binds to chromatin to promote the association of DNA replication factors and replication initiation"
>YLR003C CMS1 SGDID:S000003993, Chr XII from 157730-156855, reverse complement, Uncharacterized ORF, "Subunit of U3-containing 90S preribosome processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; overexpression rescues supressor mutant of mcm10; null mutant is viable"
>YLR004C THI73 SGDID:S000003994, Chr XII from 159505-157934, reverse complement, Verified ORF, "Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs"
>YLR005W SSL1 SGDID:S000003995, Chr XII from 160049-161434, Verified ORF, "Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p"
>YLR006C SSK1 SGDID:S000003996, Chr XII from 163893-161755, reverse complement, Verified ORF, "Cytoplasmic response regulator, part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate"
>YLR007W NSE1 SGDID:S000003997, Chr XII from 164392-165402, Verified ORF, "Essential subunit of the Mms21-Smc5-Smc6 complex; nuclear protein required for DNA repair and growth; has a nonstructural role in the maintenance of chromosomes"
>YLR008C PAM18 SGDID:S000003998, Chr XII from 166083-165577, reverse complement, Verified ORF, "Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p"
>YLR009W RLP24 SGDID:S000003999, Chr XII from 166537-167136, Verified ORF, "Essential protein with similarity to Rpl24Ap and Rpl24Bp, associated with pre-60S ribosomal subunits and required for ribosomal large subunit biogenesis"
>YLR010C TEN1 SGDID:S000004000, Chr XII from 167802-167320, reverse complement, Verified ORF, "Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p"
>YLR011W LOT6 SGDID:S000004001, Chr XII from 169103-169678, Verified ORF, "FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions"
>YLR012C YLR012C SGDID:S000004002, Chr XII from 170281-169982, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; YLR012C is not an essential gene"
>YLR013W GAT3 SGDID:S000004003, Chr XII from 171339-171764, Verified ORF, "Protein containing GATA family zinc finger motifs"
>YLR014C PPR1 SGDID:S000004004, Chr XII from 174982-172268, reverse complement, Verified ORF, "Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of genes involved in uracil biosynthesis; activity may be modulated by interaction with Tup1p"
>YLR015W BRE2 SGDID:S000004005, Chr XII from 175227-176744, Verified ORF, "Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L"
>YLR016C PML1 SGDID:S000004006, Chr XII from 177416-176802, reverse complement, Verified ORF, "Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p"
>YLR017W MEU1 SGDID:S000004007, Chr XII from 177608-178621, Verified ORF, "Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression"
>YLR018C POM34 SGDID:S000004008, Chr XII from 179606-178707, reverse complement, Verified ORF, "Integral membrane protein of the nuclear pore; has an important role in maintaining the architecture of the pore complex"
>YLR019W PSR2 SGDID:S000004009, Chr XII from 180288-181481, Verified ORF, "Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p"
>YLR020C YEH2 SGDID:S000004010, Chr XII from 183405-181789, reverse complement, Verified ORF, "Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism"
>YLR021W IRC25 SGDID:S000004011, Chr XII from 183623-184162, Verified ORF, "Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions"
>YLR022C SDO1 SGDID:S000004012, Chr XII from 184926-184174, reverse complement, Verified ORF, "Essential protein involved in 60S ribosome maturation; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archae and eukaryotes"
>YLR023C IZH3 SGDID:S000004013, Chr XII from 187129-185498, reverse complement, Verified ORF, "Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity"
>YLR024C UBR2 SGDID:S000004014, Chr XII from 193281-187663, reverse complement, Verified ORF, "Cytoplasmic ubiquitin-protein ligase (E3); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p-Ubr2p-Rad6p complex"
>YLR025W SNF7 SGDID:S000004015, Chr XII from 194452-195174, Verified ORF, "One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes"
>YLR026C SED5 SGDID:S000004016, Chr XII from 196472-195450, reverse complement, Verified ORF, "cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins"
>YLR027C AAT2 SGDID:S000004017, Chr XII from 198085-196829, reverse complement, Verified ORF, "Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells"
>YLR028C ADE16 SGDID:S000004018, Chr XII from 201315-199540, reverse complement, Verified ORF, "Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade17p; ade16 ade17 mutants require adenine and histidine"
>YLR029C RPL15A SGDID:S000004019, Chr XII from 202590-201976, reverse complement, Verified ORF, "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Bp and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA"
>YLR030W YLR030W SGDID:S000004020, Chr XII from 203290-204081, Uncharacterized ORF, "Putative protein of unknown function"
>YLR031W YLR031W SGDID:S000004021, Chr XII from 204225-204785, Uncharacterized ORF, "Putative protein of unknown function"
>YLR032W RAD5 SGDID:S000004022, Chr XII from 204991-208500, Verified ORF, "DNA helicase proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p"
>YLR033W RSC58 SGDID:S000004023, Chr XII from 208761-210269, Verified ORF, "Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance"
>YLR034C SMF3 SGDID:S000004024, Chr XII from 211933-210512, reverse complement, Verified ORF, "Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins"
>YLR035C MLH2 SGDID:S000004025, Chr XII from 214456-212369, reverse complement, Verified ORF, "Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p"
>YLR035C-A YLR035C-A SGDID:S000007225, Chr XII from 218907-215440, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); YLR035C-A is part of a mutant retrotransposon"
>YLR036C YLR036C SGDID:S000004026, Chr XII from 222132-221521, reverse complement, Uncharacterized ORF, "Putative protein of unknown function predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein"
>YLR037C PAU23 SGDID:S000004027, Chr XII from 223059-222685, reverse complement, Verified ORF, "Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth"
>YLR038C COX12 SGDID:S000004028, Chr XII from 225172-224921, reverse complement, Verified ORF, "Subunit VIb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated"
>YLR039C RIC1 SGDID:S000004029, Chr XII from 228596-225426, reverse complement, Verified ORF, "Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes"
>YLR040C YLR040C SGDID:S000004030, Chr XII from 229582-228908, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; YLR040C is not essential"
>YLR041W YLR041W SGDID:S000004031, Chr XII from 229377-229697, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YLR040C"
>YLR042C YLR042C SGDID:S000004032, Chr XII from 230451-229966, reverse complement, Uncharacterized ORF, "Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene"
>YLR043C TRX1 SGDID:S000004033, Chr XII from 232013-231702, reverse complement, Verified ORF, "Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance"
>YLR044C PDC1 SGDID:S000004034, Chr XII from 234081-232390, reverse complement, Verified ORF, "Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism"
>YLR045C STU2 SGDID:S000004035, Chr XII from 237703-235037, reverse complement, Verified ORF, "Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p"
>YLR046C YLR046C SGDID:S000004036, Chr XII from 238813-238001, reverse complement, Uncharacterized ORF, "Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance"
>YLR047C FRE8 SGDID:S000004037, Chr XII from 241407-239347, reverse complement, Verified ORF, "Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p"
>YLR048W RPS0B SGDID:S000004038, Chr XII from 242232-242321,242681-243349, Verified ORF, "Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Ap; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal"
>YLR049C YLR049C SGDID:S000004039, Chr XII from 245172-243886, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YLR050C YLR050C SGDID:S000004040, Chr XII from 246072-245587, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene"
>YLR051C FCF2 SGDID:S000004041, Chr XII from 246977-246324, reverse complement, Verified ORF, "Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon"
>YLR052W IES3 SGDID:S000004042, Chr XII from 247201-247953, Verified ORF, "Subunit of the INO80 chromatin remodeling complex"
>YLR053C YLR053C SGDID:S000004043, Chr XII from 248426-248100, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YLR054C OSW2 SGDID:S000004044, Chr XII from 250860-248717,250978-250948, reverse complement, Verified ORF, "Protein of unknown function proposed to be involved in the assembly of the spore wall"
>YLR055C SPT8 SGDID:S000004045, Chr XII from 253080-251272, reverse complement, Verified ORF, "Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters"
>YLR056W ERG3 SGDID:S000004046, Chr XII from 253861-254958, Verified ORF, "C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources"
>YLR057W YLR057W SGDID:S000004047, Chr XII from 255306-257855, Uncharacterized ORF, "Putative protein of unknown function; YLR050W is not an essential gene"
>YLR058C SHM2 SGDID:S000004048, Chr XII from 259401-257992, reverse complement, Verified ORF, "Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis"
>YLR059C REX2 SGDID:S000004049, Chr XII from 260547-259738, reverse complement, Verified ORF, "3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease"
>YLR060W FRS1 SGDID:S000004050, Chr XII from 260979-262766, Verified ORF, "Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control"
>YLR061W RPL22A SGDID:S000004051, Chr XII from 263194-263205,263595-263948, Verified ORF, "Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Bp and to rat L22 ribosomal protein"
>YLR062C BUD28 SGDID:S000004052, Chr XII from 263954-263577, reverse complement, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay"
>YLR063W YLR063W SGDID:S000004053, Chr XII from 264157-265254, Uncharacterized ORF, "Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene"
>YLR064W PER33 SGDID:S000004054, Chr XII from 265456-266277, Verified ORF, "Putative protein of unknown function; localizes to the endoplasmic reticulum with some nuclear pore complex association; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p; YLR064W is not an essential gene"
>YLR065C YLR065C SGDID:S000004055, Chr XII from 266918-266373, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; YLR065C is not an essential gene"
>YLR066W SPC3 SGDID:S000004056, Chr XII from 267169-267723, Verified ORF, "Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23"
>YLR067C PET309 SGDID:S000004057, Chr XII from 270710-267813, reverse complement, Verified ORF, "Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs)"
>YLR068W FYV7 SGDID:S000004058, Chr XII from 271008-271463, Verified ORF, "Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin"
>YLR069C MEF1 SGDID:S000004059, Chr XII from 273915-271630, reverse complement, Verified ORF, "Mitochondrial elongation factor involved in translational elongation"
>YLR070C XYL2 SGDID:S000004060, Chr XII from 275211-274141, reverse complement, Verified ORF, "Xylitol dehydrogenase, converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect"
>YLR071C RGR1 SGDID:S000004061, Chr XII from 278626-275378, reverse complement, Verified ORF, "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation"
>YLR072W YLR072W SGDID:S000004062, Chr XII from 278862-280943, Uncharacterized ORF, "Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene"
>YLR073C RFU1 SGDID:S000004063, Chr XII from 281621-281019, reverse complement, Verified ORF, "Protein that inhibits Doa4p deubiquitinating activity; contributes to ubiquitin homeostasis by regulating the conversion of free ubiquitin chains to ubiquitin monomers by Doa4p; GFP-fusion protein localizes to endosomes"
>YLR074C BUD20 SGDID:S000004064, Chr XII from 282456-281956, reverse complement, Verified ORF, "Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern"
>YLR075W RPL10 SGDID:S000004065, Chr XII from 282927-283592, Verified ORF, "Protein component of the large (60S) ribosomal subunit, responsible for joining the 40S and 60S subunits; regulates translation initiation; has similarity to rat L10 ribosomal protein and to members of the QM gene family"
>YLR076C YLR076C SGDID:S000004066, Chr XII from 283607-283185, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10"
>YLR077W FMP25 SGDID:S000004067, Chr XII from 283872-285623, Verified ORF, "Mitochondrial inner membrane protein required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria"
>YLR078C BOS1 SGDID:S000004068, Chr XII from 286467-285736,286559-286557, reverse complement, Verified ORF, "v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi"
>YLR079W SIC1 SGDID:S000004069, Chr XII from 286820-287674, Verified ORF, "Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1"
>YLR080W EMP46 SGDID:S000004070, Chr XII from 287916-289250, Verified ORF, "Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport"
>YLR081W GAL2 SGDID:S000004071, Chr XII from 290212-291936, Verified ORF, "Galactose permease, required for utilization of galactose; also able to transport glucose"
>YLR082C SRL2 SGDID:S000004072, Chr XII from 293572-292394, reverse complement, Verified ORF, "Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation"
>YLR083C EMP70 SGDID:S000004073, Chr XII from 296094-294091, reverse complement, Verified ORF, "Protein with a role in cellular adhesion and filamentous growth; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; 24kDa cleavage product found in endosome-enriched membrane fractions"
>YLR084C RAX2 SGDID:S000004074, Chr XII from 300251-296589, reverse complement, Verified ORF, "N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p"
>YLR085C ARP6 SGDID:S000004075, Chr XII from 301989-300673, reverse complement, Verified ORF, "Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A"
>YLR086W SMC4 SGDID:S000004076, Chr XII from 302243-306499, Verified ORF, "Subunit of the condensin complex; reorganizes chromosomes during cell division; forms a complex with Smc2p that has ATP-hydrolyzing and DNA-binding activity; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate"
>YLR087C CSF1 SGDID:S000004077, Chr XII from 315731-306855, reverse complement, Verified ORF, "Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YLR088W GAA1 SGDID:S000004078, Chr XII from 316107-317951, Verified ORF, "Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER"
>YLR089C ALT1 SGDID:S000004079, Chr XII from 320015-318237, reverse complement, Uncharacterized ORF, "Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthetic and catabolic processes; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YLR090W XDJ1 SGDID:S000004080, Chr XII from 320701-322080, Verified ORF, "Putative chaperone, homolog of E. coli DnaJ, closely related to Ydj1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YLR091W GEP5 SGDID:S000004081, Chr XII from 322297-323178, Verified ORF, "Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine"
>YLR092W SUL2 SGDID:S000004082, Chr XII from 323544-326225, Verified ORF, "High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates"
>YLR093C NYV1 SGDID:S000004083, Chr XII from 327258-326513,327415-327400, reverse complement, Verified ORF, "v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane"
>YLR094C GIS3 SGDID:S000004084, Chr XII from 329238-327730, reverse complement, Verified ORF, "Protein of unknown function"
>YLR095C IOC2 SGDID:S000004085, Chr XII from 332115-329677, reverse complement, Verified ORF, "Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif"
>YLR096W KIN2 SGDID:S000004086, Chr XII from 332590-336033, Verified ORF, "Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p"
>YLR097C HRT3 SGDID:S000004087, Chr XII from 337265-336231, reverse complement, Verified ORF, "Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies"
>YLR098C CHA4 SGDID:S000004088, Chr XII from 339473-337527, reverse complement, Verified ORF, "DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain"
>YLR099C ICT1 SGDID:S000004089, Chr XII from 340928-339744, reverse complement, Verified ORF, "Lysophosphatidic acid acyltransferase, responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress"
>YLR099W-A YLR099W-A SGDID:S000007618, Chr XII from 341325-341588, Uncharacterized ORF, "Putative protein of unknown function"
>YLR100W ERG27 SGDID:S000004090, Chr XII from 341810-342853, Verified ORF, "3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs"
>YLR101C YLR101C SGDID:S000004091, Chr XII from 342961-342566, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W"
>YLR102C APC9 SGDID:S000004092, Chr XII from 343767-342970, reverse complement, Verified ORF, "Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition"
>YLR103C CDC45 SGDID:S000004093, Chr XII from 345941-343989, reverse complement, Verified ORF, "DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes"
>YLR104W LCL2 SGDID:S000004094, Chr XII from 346585-346980, Uncharacterized ORF, "Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD)"
>YLR105C SEN2 SGDID:S000004095, Chr XII from 348180-347047, reverse complement, Verified ORF, "Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease"
>YLR106C MDN1 SGDID:S000004096, Chr XII from 363738-349006, reverse complement, Verified ORF, "Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p); acts in removal of ribosomal biogenesis factors at successive steps of pre-60S assembly and export from nucleus"
>YLR107W REX3 SGDID:S000004097, Chr XII from 364116-365330, Verified ORF, "RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases"
>YLR108C YLR108C SGDID:S000004098, Chr XII from 368124-366667, reverse complement, Uncharacterized ORF, "Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene"
>YLR109W AHP1 SGDID:S000004099, Chr XII from 368781-369311, Verified ORF, "Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p"
>YLR110C CCW12 SGDID:S000004100, Chr XII from 370098-369697, reverse complement, Verified ORF, "Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor"
>YLR111W YLR111W SGDID:S000004101, Chr XII from 370391-370723, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YLR112W YLR112W SGDID:S000004102, Chr XII from 370791-371210, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YLR113W HOG1 SGDID:S000004103, Chr XII from 371620-372927, Verified ORF, "Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p"
>YLR114C AVL9 SGDID:S000004104, Chr XII from 377238-374944, reverse complement, Verified ORF, "Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms"
>YLR115W CFT2 SGDID:S000004105, Chr XII from 377985-380564, Verified ORF, "Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein."
>YLR116W MSL5 SGDID:S000004106, Chr XII from 380822-382252, Verified ORF, "Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA"
>YLR117C CLF1 SGDID:S000004107, Chr XII from 384534-382471, reverse complement, Verified ORF, "Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins"
>YLR118C YLR118C SGDID:S000004108, Chr XII from 385408-384725, reverse complement, Verified ORF, "Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS"
>YLR119W SRN2 SGDID:S000004109, Chr XII from 385534-386175, Verified ORF, "Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus"
>YLR120C YPS1 SGDID:S000004110, Chr XII from 388220-386511, reverse complement, Verified ORF, "Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor"
>YLR120W-A YLR120W-A SGDID:S000028674, Chr XII from 388672-388773, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ORF YLR121C"
>YLR121C YPS3 SGDID:S000004111, Chr XII from 390270-388744, reverse complement, Verified ORF, "Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor"
>YLR122C YLR122C SGDID:S000004112, Chr XII from 391331-390954, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C"
>YLR123C YLR123C SGDID:S000004113, Chr XII from 391407-391078, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif"
>YLR124W YLR124W SGDID:S000004114, Chr XII from 391600-391944, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YLR125W YLR125W SGDID:S000004115, Chr XII from 393484-393894, Uncharacterized ORF, "Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene"
>YLR126C YLR126C SGDID:S000004116, Chr XII from 395520-394765, reverse complement, Uncharacterized ORF, "Putative protein of unknown function with similarity to glutamine amidotransferase proteins; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein"
>YLR127C APC2 SGDID:S000004117, Chr XII from 398319-395758, reverse complement, Verified ORF, "Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; similar to cullin Cdc53p"
>YLR128W DCN1 SGDID:S000004118, Chr XII from 398530-398532,398627-399433, Verified ORF, "Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation"
>YLR129W DIP2 SGDID:S000004119, Chr XII from 399657-402488, Verified ORF, "Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex"
>YLR130C ZRT2 SGDID:S000004120, Chr XII from 404062-402794, reverse complement, Verified ORF, "Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor"
>YLR131C ACE2 SGDID:S000004121, Chr XII from 406822-404510, reverse complement, Verified ORF, "Transcription factor that activates expression of early G1-specific genes, localizes to daughter cell nuclei after cytokinesis and delays G1 progression in daughters, localization is regulated by phosphorylation; potential Cdc28p substrate"
>YLR132C YLR132C SGDID:S000004122, Chr XII from 408155-407283, reverse complement, Uncharacterized ORF, "Essential protein of unknown function; fluorescent protein (GFP or YFP)-tagged protein localizes to mitochondria, cytoplasm and nucleus"
>YLR133W CKI1 SGDID:S000004123, Chr XII from 408445-410193, Verified ORF, "Choline kinase, catalyzing the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway"
>YLR134W PDC5 SGDID:S000004124, Chr XII from 410723-412414, Verified ORF, "Minor isoform of pyruvate decarboxylase, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism"
>YLR135W SLX4 SGDID:S000004125, Chr XII from 413281-415527, Verified ORF, "Endonuclease involved in processing DNA during recombination and repair; cleaves branched structures in a complex with Slx1p; involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing"
>YLR136C TIS11 SGDID:S000004126, Chr XII from 416658-415801, reverse complement, Verified ORF, "mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis"
>YLR137W YLR137W SGDID:S000004127, Chr XII from 417006-418109, Uncharacterized ORF, "Putative S-adenosylmethionine-dependent methyltransferase"
>YLR138W NHA1 SGDID:S000004128, Chr XII from 418437-421394, Verified ORF, "Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH"
>YLR139C SLS1 SGDID:S000004129, Chr XII from 423473-421542, reverse complement, Verified ORF, "Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery"
>YLR140W YLR140W SGDID:S000004130, Chr XII from 423474-423800, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I"
>YLR141W RRN5 SGDID:S000004131, Chr XII from 423683-424774, Verified ORF, "Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p"
>YLR142W PUT1 SGDID:S000004132, Chr XII from 425186-426616, Verified ORF, "Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source"
>YLR143W YLR143W SGDID:S000004133, Chr XII from 427329-429386, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; YLR143W is not an essential gene"
>YLR144C ACF2 SGDID:S000004134, Chr XII from 432016-429677, reverse complement, Verified ORF, "Intracellular beta-1,3-endoglucanase, expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly"
>YLR145W RMP1 SGDID:S000004135, Chr XII from 432168-432773, Verified ORF, "Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P"
>YLR146C SPE4 SGDID:S000004136, Chr XII from 433725-432823, reverse complement, Verified ORF, "Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid"
>YLR146W-A YLR146W-A SGDID:S000113566, Chr XII from 433870-434058, Uncharacterized ORF, "Putative protein of unknown function"
>YLR147C SMD3 SGDID:S000004137, Chr XII from 434463-434158, reverse complement, Verified ORF, "Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3"
>YLR148W PEP3 SGDID:S000004138, Chr XII from 434641-437397, Verified ORF, "Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis"
>YLR149C YLR149C SGDID:S000004139, Chr XII from 439823-437631, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene"
>YLR149C-A YLR149C-A SGDID:S000007619, Chr XII from 440456-440370, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YLR150W STM1 SGDID:S000004140, Chr XII from 440467-441288, Verified ORF, "Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure"
>YLR151C PCD1 SGDID:S000004141, Chr XII from 442737-441715, reverse complement, Verified ORF, "Peroxisomal nudix pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids"
>YLR152C YLR152C SGDID:S000004142, Chr XII from 444688-442958, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; YLR152C is not an essential gene"
>YLR153C ACS2 SGDID:S000004143, Chr XII from 447575-445524, reverse complement, Verified ORF, "Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions"
>YLR154C RNH203 SGDID:S000004144, Chr XII from 448314-447982, reverse complement, Verified ORF, "Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome"
>YLR154C-G YLR154C-G SGDID:S000028561, Chr XII from 462671-462522, reverse complement, Uncharacterized ORF, "Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF is contained within RDN25-2 and RDN37-2"
>YLR154C-H YLR154C-H SGDID:S000028562, Chr XII from 468958-468827, reverse complement, Uncharacterized ORF, "Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-2"
>YLR154W-A YLR154W-A SGDID:S000028675, Chr XII from 452438-452623, Dubious ORF, "Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand"
>YLR154W-B YLR154W-B SGDID:S000028563, Chr XII from 454392-454556, Dubious ORF, "Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand"
>YLR154W-C TAR1 SGDID:S000028422, Chr XII from 454696-455070, Verified ORF, "Mitochondrial protein potentially involved in regulation of respiratory metabolism; interacts genetically with RPO41 and physically with Coq5p; encoded within the 25S rRNA gene on the opposite strand"
>YLR154W-E YLR154W-E SGDID:S000028676, Chr XII from 455433-455636, Dubious ORF, "Dubious open reading frame unlikely to encode a protein; encoded within the the 35S rRNA gene on the opposite strand"
>YLR154W-F YLR154W-F SGDID:S000028843, Chr XII from 455883-456023, Dubious ORF, "Dubious open reading frame unlikely to encode a protein; encoded within the the 35S rRNA gene on the opposite strand"
>YLR155C ASP3-1 SGDID:S000004145, Chr XII from 470405-469317, reverse complement, Verified ORF, "Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; reference strain S288C has four copies of ASP3"
>YLR156C-A YLR156C-A SGDID:S000028564, Chr XII from 472610-472479, reverse complement, Uncharacterized ORF, "Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-3"
>YLR156W YLR156W SGDID:S000004146, Chr XII from 472113-472457, Uncharacterized ORF, "Putative protein of unknown function; exhibits a two-hybrid interaction with Jsn1p in a large-scale analysis"
>YLR157C ASP3-2 SGDID:S000004147, Chr XII from 474057-472969, reverse complement, Verified ORF, "Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; reference strain S288C has four copies of ASP3"
>YLR157C-A YLR157C-A SGDID:S000007373, Chr XII from 481601-480279, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YLR157C-B YLR157C-B SGDID:S000007374, Chr XII from 480295-476333,481601-480297, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YLR157C-C YLR157C-C SGDID:S000028565, Chr XII from 482190-482059, reverse complement, Uncharacterized ORF, "Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-4"
>YLR157W-D YLR157W-D SGDID:S000028677, Chr XII from 475764-475976, Uncharacterized ORF, "Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YLR157W-E YLR157W-E SGDID:S000028678, Chr XII from 481873-482037, Uncharacterized ORF, "Putative protein of unknown function identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; partially overlaps a Ty1 element"
>YLR158C ASP3-3 SGDID:S000004148, Chr XII from 483637-482549, reverse complement, Verified ORF, "Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; reference strain S288C has four copies of ASP3"
>YLR159C-A YLR159C-A SGDID:S000028566, Chr XII from 485842-485711, reverse complement, Uncharacterized ORF, "Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-5"
>YLR159W YLR159W SGDID:S000004149, Chr XII from 485345-485689, Uncharacterized ORF, "Putative protein of unknown function; YLR156W, YLR159W, and YLR161W are three identical open reading frames encoded near the ribosomal DNA region of chromosome 12"
>YLR160C ASP3-4 SGDID:S000004150, Chr XII from 487289-486201, reverse complement, Verified ORF, "Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; reference strain S288C has four copies of ASP3"
>YLR161W YLR161W SGDID:S000004151, Chr XII from 488997-489341, Uncharacterized ORF, "Putative protein of unknown function; YLR156W, YLR159W, and YLR161W are three identical open reading frames encoded near the ribosomal DNA region of chromosome 12"
>YLR162W YLR162W SGDID:S000004152, Chr XII from 489573-489929, Uncharacterized ORF, "Putative protein of unknown function; overexpression confers resistance to the antimicrobial peptide MiAMP1"
>YLR162W-A RRT15 SGDID:S000028567, Chr XII from 490406-490594, Uncharacterized ORF, "Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; identified in a screen for mutants with decreased levels of rDNA transcription"
>YLR163C MAS1 SGDID:S000004153, Chr XII from 493254-491866, reverse complement, Verified ORF, "Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins"
>YLR163W-A YLR163W-A SGDID:S000028844, Chr XII from 492812-492925, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data"
>YLR164W YLR164W SGDID:S000004154, Chr XII from 493883-494389, Verified ORF, "Mitochondrial inner membrane of unknown function; similar to Tim18p and Sdh4p; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner"
>YLR165C PUS5 SGDID:S000004155, Chr XII from 495258-494494, reverse complement, Verified ORF, "Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability"
>YLR166C SEC10 SGDID:S000004156, Chr XII from 498044-495429, reverse complement, Verified ORF, "Essential 100kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis"
>YLR167W RPS31 SGDID:S000004157, Chr XII from 498947-499405, Verified ORF, "Fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B"
>YLR168C UPS2 SGDID:S000004158, Chr XII from 500270-499578, reverse complement, Verified ORF, "Mitochondrial intermembrane space protein involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI"
>YLR169W YLR169W SGDID:S000004159, Chr XII from 500335-500688, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YLR170C APS1 SGDID:S000004160, Chr XII from 501049-500579, reverse complement, Verified ORF, "Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex"
>YLR171W YLR171W SGDID:S000004161, Chr XII from 500733-501122, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YLR172C DPH5 SGDID:S000004162, Chr XII from 502162-501260, reverse complement, Verified ORF, "Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm"
>YLR173W YLR173W SGDID:S000004163, Chr XII from 502421-504247, Uncharacterized ORF, "Putative protein of unknown function"
>YLR174W IDP2 SGDID:S000004164, Chr XII from 504591-505829, Verified ORF, "Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose"
>YLR175W CBF5 SGDID:S000004165, Chr XII from 506134-507585, Verified ORF, "Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita"
>YLR176C RFX1 SGDID:S000004166, Chr XII from 510232-507797, reverse complement, Verified ORF, "Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins"
>YLR177W YLR177W SGDID:S000004167, Chr XII from 511054-512940, Uncharacterized ORF, "Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; YLR177W is not an essential gene"
>YLR178C TFS1 SGDID:S000004168, Chr XII from 513821-513162, reverse complement, Verified ORF, "Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase"
>YLR179C YLR179C SGDID:S000004169, Chr XII from 514713-514108, reverse complement, Verified ORF, "Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus"
>YLR180W SAM1 SGDID:S000004170, Chr XII from 515262-516410, Verified ORF, "S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)"
>YLR181C VTA1 SGDID:S000004171, Chr XII from 517670-516678, reverse complement, Verified ORF, "Multivesicular body (MVB) protein involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain"
>YLR182W SWI6 SGDID:S000004172, Chr XII from 517940-520351, Verified ORF, "Transcription cofactor, forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization"
>YLR183C TOS4 SGDID:S000004173, Chr XII from 522012-520543, reverse complement, Verified ORF, "Forkhead Associated domain containing protein and putative transcription factor found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; similar to PLM2"
>YLR184W YLR184W SGDID:S000004174, Chr XII from 522106-522453, Dubious ORF, "Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YLR185W RPL37A SGDID:S000004175, Chr XII from 522663-522669,523029-523288, Verified ORF, "Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Bp and to rat L37 ribosomal protein"
>YLR186W EMG1 SGDID:S000004176, Chr XII from 523632-524390, Verified ORF, "Member of the alpha/beta knot fold methyltransferase superfamily; required for maturation of 18S rRNA and for 40S ribosome production; interacts with RNA and with S-adenosylmethionine; associates with spindle/microtubules; forms homodimers"
>YLR187W SKG3 SGDID:S000004177, Chr XII from 524865-527945, Uncharacterized ORF, "Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Caf120p and Skg4p"
>YLR188W MDL1 SGDID:S000004178, Chr XII from 528300-530387, Verified ORF, "Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress"
>YLR189C ATG26 SGDID:S000004179, Chr XII from 534393-530797, reverse complement, Verified ORF, "UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy"
>YLR190W MMR1 SGDID:S000004180, Chr XII from 535214-536689, Verified ORF, "Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p"
>YLR191W PEX13 SGDID:S000004181, Chr XII from 537272-538432, Verified ORF, "Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p"
>YLR192C HCR1 SGDID:S000004182, Chr XII from 539589-538792, reverse complement, Verified ORF, "Dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA"
>YLR193C UPS1 SGDID:S000004183, Chr XII from 540536-540009, reverse complement, Verified ORF, "Mitochondrial intermembrane space protein that regulates mitochondrial cardiolipin levels, null has defects in Mgm1p processing, integrity of mitochondrial inner membrane complexes, and mitochondrial morphology; ortholog of human PRELI"
>YLR194C YLR194C SGDID:S000004184, Chr XII from 541573-540809, reverse complement, Uncharacterized ORF, "Structural constituent of the cell wall attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress"
>YLR195C NMT1 SGDID:S000004185, Chr XII from 543304-541937, reverse complement, Verified ORF, "N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction"
>YLR196W PWP1 SGDID:S000004186, Chr XII from 543968-545698, Verified ORF, "Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily"
>YLR197W NOP56 SGDID:S000004187, Chr XII from 546097-547611, Verified ORF, "Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects"
>YLR198C YLR198C SGDID:S000004188, Chr XII from 547645-547286, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W"
>YLR199C PBA1 SGDID:S000004189, Chr XII from 548677-547853,548769-548764, reverse complement, Verified ORF, "Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly"
>YLR200W YKE2 SGDID:S000004190, Chr XII from 549012-549356, Verified ORF, "Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin"
>YLR201C COQ9 SGDID:S000004191, Chr XII from 550293-549511, reverse complement, Verified ORF, "Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes"
>YLR202C YLR202C SGDID:S000004192, Chr XII from 550458-550194,550636-550575, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron"
>YLR203C MSS51 SGDID:S000004193, Chr XII from 551960-550650, reverse complement, Verified ORF, "Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase"
>YLR204W QRI5 SGDID:S000004194, Chr XII from 552270-552605, Verified ORF, "Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA"
>YLR205C HMX1 SGDID:S000004195, Chr XII from 553677-552724, reverse complement, Verified ORF, "ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants"
>YLR206W ENT2 SGDID:S000004196, Chr XII from 554578-556419, Verified ORF, "Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus"
>YLR207W HRD3 SGDID:S000004197, Chr XII from 556788-559289, Verified ORF, "Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events"
>YLR208W SEC13 SGDID:S000004198, Chr XII from 559551-560444, Verified ORF, "Component of both the Nup84 nuclear pore sub-complex and the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport and nuclear pore complex organization"
>YLR209C PNP1 SGDID:S000004199, Chr XII from 561732-560797, reverse complement, Verified ORF, "Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway"
>YLR210W CLB4 SGDID:S000004200, Chr XII from 562008-563390, Verified ORF, "B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation"
>YLR211C YLR211C SGDID:S000004201, Chr XII from 564454-563792,564531-564514, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron"
>YLR212C TUB4 SGDID:S000004202, Chr XII from 566281-564860, reverse complement, Verified ORF, "Gamma-tubulin, involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body"
>YLR213C CRR1 SGDID:S000004203, Chr XII from 567922-566654, reverse complement, Verified ORF, "Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation"
>YLR214W FRE1 SGDID:S000004204, Chr XII from 568567-570627, Verified ORF, "Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels"
>YLR215C CDC123 SGDID:S000004205, Chr XII from 571858-570776, reverse complement, Verified ORF, "Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein"
>YLR216C CPR6 SGDID:S000004206, Chr XII from 573211-572096, reverse complement, Verified ORF, "Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity"
>YLR217W YLR217W SGDID:S000004207, Chr XII from 572909-573232, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CPR6"
>YLR218C COA4 SGDID:S000004208, Chr XII from 573918-573466, reverse complement, Verified ORF, "Twin Cx(9)C protein involved in cytochrome c oxidase assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors"
>YLR219W MSC3 SGDID:S000004209, Chr XII from 574151-576337, Verified ORF, "Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate"
>YLR220W CCC1 SGDID:S000004210, Chr XII from 576825-577793, Verified ORF, "Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation"
>YLR221C RSA3 SGDID:S000004211, Chr XII from 579024-578362, reverse complement, Verified ORF, "Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus"
>YLR222C UTP13 SGDID:S000004212, Chr XII from 581771-579318, reverse complement, Verified ORF, "Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA"
>YLR222C-A YLR222C-A SGDID:S000028568, Chr XII from 582236-582006, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene IFH1"
>YLR223C IFH1 SGDID:S000004213, Chr XII from 585490-582233, reverse complement, Verified ORF, "Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing"
>YLR224W YLR224W SGDID:S000004214, Chr XII from 586464-587573, Uncharacterized ORF, "F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene"
>YLR225C YLR225C SGDID:S000004215, Chr XII from 588918-587695, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene"
>YLR226W BUR2 SGDID:S000004216, Chr XII from 589354-590541, Verified ORF, "Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II"
>YLR227C ADY4 SGDID:S000004217, Chr XII from 592043-590562, reverse complement, Verified ORF, "Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane"
>YLR227W-A YLR227W-A SGDID:S000007375, Chr XII from 593438-594760, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YLR227W-B YLR227W-B SGDID:S000007376, Chr XII from 593438-594742,594744-598706, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YLR228C ECM22 SGDID:S000004218, Chr XII from 602463-600019, reverse complement, Verified ORF, "Sterol regulatory element binding protein, regulates transcription of sterol biosynthetic genes; contains Zn[2]-Cys[6] binuclear cluster; homologous to Upc2p; relocates from intracellular membranes to perinuclear foci on sterol depletion"
>YLR229C CDC42 SGDID:S000004219, Chr XII from 604787-604212, reverse complement, Verified ORF, "Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins"
>YLR230W YLR230W SGDID:S000004220, Chr XII from 604574-604879, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity"
>YLR231C BNA5 SGDID:S000004221, Chr XII from 607119-605758, reverse complement, Verified ORF, "Kynureninase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p"
>YLR232W YLR232W SGDID:S000004222, Chr XII from 606830-607177, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene BNA5"
>YLR233C EST1 SGDID:S000004223, Chr XII from 609524-607425, reverse complement, Verified ORF, "TLC1 RNA-associated factor involved in telomere length regulation as recruitment subunit of telomerase; has G-quadruplex promoting activity that is required for telomere elongation; possible role in activating telomere-bound Est2p-TLC1-RNA"
>YLR234W TOP3 SGDID:S000004224, Chr XII from 609783-611753, Verified ORF, "DNA Topoisomerase III, conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially, involved in telomere stability and regulation of mitotic recombination"
>YLR235C YLR235C SGDID:S000004225, Chr XII from 611930-611532, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TOP3"
>YLR236C YLR236C SGDID:S000004226, Chr XII from 612117-611794, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YLR237W THI7 SGDID:S000004227, Chr XII from 612367-614163, Verified ORF, "Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia"
>YLR238W FAR10 SGDID:S000004228, Chr XII from 614755-616191, Verified ORF, "Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate"
>YLR239C LIP2 SGDID:S000004229, Chr XII from 617318-616332, reverse complement, Verified ORF, "Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups"
>YLR240W VPS34 SGDID:S000004230, Chr XII from 617533-620160, Verified ORF, "Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p"
>YLR241W YLR241W SGDID:S000004231, Chr XII from 620473-622821, Uncharacterized ORF, "Putative protein of unknown function, may be involved in detoxification"
>YLR242C ARV1 SGDID:S000004232, Chr XII from 623883-622918, reverse complement, Verified ORF, "Protein functioning in transport of glycosylphosphatidylinositol intermediates into ER lumen; required for normal intracellular sterol distribution; human ARV1 required for normal cholesterol and bile acid homeostasis; similar to Nup120p"
>YLR243W YLR243W SGDID:S000004233, Chr XII from 624203-625021, Uncharacterized ORF, "Putative protein of unknown function; YLR243W is an essential gene"
>YLR244C MAP1 SGDID:S000004234, Chr XII from 626331-625168, reverse complement, Verified ORF, "Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p"
>YLR245C CDD1 SGDID:S000004235, Chr XII from 626930-626502, reverse complement, Verified ORF, "Cytidine deaminase; catalyzes the modification of cytidine to uridine in vitro but native RNA substrates have not been identified, localizes to both the nucleus and cytoplasm"
>YLR246W ERF2 SGDID:S000004236, Chr XII from 627118-628197, Verified ORF, "Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole"
>YLR247C IRC20 SGDID:S000004237, Chr XII from 633354-628684, reverse complement, Verified ORF, "Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci"
>YLR248W RCK2 SGDID:S000004238, Chr XII from 634252-636084, Verified ORF, "Protein kinase involved in the response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; similar to CaM (calmodulin) kinases"
>YLR249W YEF3 SGDID:S000004239, Chr XII from 636780-639914, Verified ORF, "Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex; contains two ABC cassettes; binds and hydrolyzes ATP"
>YLR250W SSP120 SGDID:S000004240, Chr XII from 640317-641021, Verified ORF, "Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern"
>YLR251W SYM1 SGDID:S000004241, Chr XII from 641464-642057, Verified ORF, "Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17"
>YLR252W YLR252W SGDID:S000004242, Chr XII from 641957-642262, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism"
>YLR253W YLR253W SGDID:S000004243, Chr XII from 642627-644336, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; transcription is periodic during the metabolic cycle; YLR253W is not an essential gene"
>YLR254C NDL1 SGDID:S000004244, Chr XII from 644973-644404, reverse complement, Verified ORF, "Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends"
>YLR255C YLR255C SGDID:S000004245, Chr XII from 645953-645600, reverse complement, Dubious ORF, "Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YLR256W HAP1 SGDID:S000004246, Chr XII from 646415-650923, Verified ORF, "Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus"
>YLR256W-A YLR256W-A SGDID:S000007377, Chr XII from 651117-652439, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YLR257W YLR257W SGDID:S000004247, Chr XII from 658826-659791, Uncharacterized ORF, "Putative protein of unknown function"
>YLR258W GSY2 SGDID:S000004248, Chr XII from 660716-662833, Verified ORF, "Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase"
>YLR259C HSP60 SGDID:S000004249, Chr XII from 665002-663284, reverse complement, Verified ORF, "Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated"
>YLR260W LCB5 SGDID:S000004250, Chr XII from 665844-667907, Verified ORF, "Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules"
>YLR261C VPS63 SGDID:S000004251, Chr XII from 668563-668237, reverse complement, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect"
>YLR262C YPT6 SGDID:S000004252, Chr XII from 668891-668244, reverse complement, Verified ORF, "Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6"
>YLR262C-A TMA7 SGDID:S000007246, Chr XII from 669662-669468, reverse complement, Verified ORF, "Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin"
>YLR263W RED1 SGDID:S000004253, Chr XII from 670340-672823, Verified ORF, "Protein component of the axial elements of the synaptonemal complex, involved in chromosome segregation during the first meiotic division; interacts with Hop1p; required for wild-type levels of Mek1p kinase activity"
>YLR264C-A YLR264C-A SGDID:S000028808, Chr XII from 673944-673828, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YLR264W RPS28B SGDID:S000004254, Chr XII from 673131-673334, Verified ORF, "Protein component of the small (40S) ribosomal subunit; nearly identical to Rps28Ap and has similarity to rat S28 ribosomal protein"
>YLR265C NEJ1 SGDID:S000004255, Chr XII from 675455-674427, reverse complement, Verified ORF, "Protein involved in regulation of nonhomologous end joining; interacts with DNA ligase IV components Dnl4p and Lif1p; repressed by MAT heterozygosity; regulates cellular distribution of Lif1p"
>YLR266C PDR8 SGDID:S000004256, Chr XII from 677724-675619, reverse complement, Verified ORF, "Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon"
>YLR267W BOP2 SGDID:S000004257, Chr XII from 678212-679924, Uncharacterized ORF, "Protein of unknown function"
>YLR268W SEC22 SGDID:S000004258, Chr XII from 680200-680844, Verified ORF, "R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog"
>YLR269C YLR269C SGDID:S000004259, Chr XII from 681216-680866, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YLR270W DCS1 SGDID:S000004260, Chr XII from 681186-682238, Verified ORF, "Non-essential hydrolase involved in mRNA decapping, may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p"
>YLR271W YLR271W SGDID:S000004261, Chr XII from 682737-683561, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS"
>YLR272C YCS4 SGDID:S000004262, Chr XII from 687202-683672, reverse complement, Verified ORF, "Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus"
>YLR273C PIG1 SGDID:S000004263, Chr XII from 691029-689083, reverse complement, Verified ORF, "Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase"
>YLR274W MCM5 SGDID:S000004264, Chr XII from 691555-693882, Verified ORF, "Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase"
>YLR275W SMD2 SGDID:S000004265, Chr XII from 694378-694382,694473-694800, Verified ORF, "Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2"
>YLR276C DBP9 SGDID:S000004266, Chr XII from 696830-695046, reverse complement, Verified ORF, "ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 60S ribosomal subunit"
>YLR277C YSH1 SGDID:S000004267, Chr XII from 699495-697156, reverse complement, Verified ORF, "Putative endoribonuclease, subunit of the mRNA cleavage and polyadenylation specificity complex; required for 3' processing, splicing, and transcriptional termination of mRNAs and snoRNAs"
>YLR278C YLR278C SGDID:S000004268, Chr XII from 704024-699999, reverse complement, Uncharacterized ORF, "Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene"
>YLR279W YLR279W SGDID:S000004269, Chr XII from 704309-704698, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YLR280C YLR280C SGDID:S000004270, Chr XII from 704833-704483, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YLR281C YLR281C SGDID:S000004271, Chr XII from 704960-704493, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene"
>YLR282C YLR282C SGDID:S000004272, Chr XII from 705412-705071, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition"
>YLR283W YLR283W SGDID:S000004273, Chr XII from 705186-706130, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene"
>YLR284C ECI1 SGDID:S000004274, Chr XII from 707040-706198, reverse complement, Verified ORF, "Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced"
>YLR285C-A YLR285C-A SGDID:S000028569, Chr XII from 708338-708168, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by fungal homology and RT-PCR"
>YLR285W NNT1 SGDID:S000004275, Chr XII from 707360-708145, Verified ORF, "Putative nicotinamide N-methyltransferase, has a role in rDNA silencing and in lifespan determination"
>YLR286C CTS1 SGDID:S000004276, Chr XII from 710136-708448, reverse complement, Verified ORF, "Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p"
>YLR286W-A YLR286W-A SGDID:S000028679, Chr XII from 708562-708696, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene CTS1"
>YLR287C YLR287C SGDID:S000004277, Chr XII from 712058-710991, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene"
>YLR287C-A RPS30A SGDID:S000004278, Chr XII from 712725-712537,713158-713156, reverse complement, Verified ORF, "Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Bp and has similarity to rat S30 ribosomal protein"
>YLR288C MEC3 SGDID:S000004279, Chr XII from 714904-713480, reverse complement, Verified ORF, "DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1"
>YLR289W GUF1 SGDID:S000004280, Chr XII from 715089-717026, Verified ORF, "Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor"
>YLR290C YLR290C SGDID:S000004281, Chr XII from 717978-717145, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene"
>YLR291C GCD7 SGDID:S000004282, Chr XII from 719462-718317, reverse complement, Verified ORF, "Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression"
>YLR292C SEC72 SGDID:S000004283, Chr XII from 720370-719789, reverse complement, Verified ORF, "Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER"
>YLR293C GSP1 SGDID:S000004284, Chr XII from 721430-720771, reverse complement, Verified ORF, "Ran GTPase, GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; regulated by Srm1p, Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p and Kap95p; yeast Gsp2p homolog"
>YLR294C YLR294C SGDID:S000004285, Chr XII from 722030-721701, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14"
>YLR295C ATP14 SGDID:S000004286, Chr XII from 722373-721999, reverse complement, Verified ORF, "Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis"
>YLR296W YLR296W SGDID:S000004287, Chr XII from 722978-723304, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YLR297W YLR297W SGDID:S000004288, Chr XII from 724044-724433, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YLR297W is not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation"
>YLR298C YHC1 SGDID:S000004289, Chr XII from 725416-724721, reverse complement, Verified ORF, "Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site"
>YLR299C-A YLR299C-A SGDID:S000028680, Chr XII from 728003-727911, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ECM38"
>YLR299W ECM38 SGDID:S000004290, Chr XII from 726069-728051, Verified ORF, "Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation"
>YLR300W EXG1 SGDID:S000004291, Chr XII from 728955-730301, Verified ORF, "Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes"
>YLR301W YLR301W SGDID:S000004292, Chr XII from 730825-731559, Uncharacterized ORF, "Protein of unknown function that interacts with Sec72p"
>YLR302C YLR302C SGDID:S000004293, Chr XII from 732553-732191, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YLR303W MET17 SGDID:S000004294, Chr XII from 732542-733876, Verified ORF, "Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesis"
>YLR304C ACO1 SGDID:S000004295, Chr XII from 737548-735212, reverse complement, Verified ORF, "Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy"
>YLR305C STT4 SGDID:S000004296, Chr XII from 743863-738161, reverse complement, Verified ORF, "Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization"
>YLR306W UBC12 SGDID:S000004297, Chr XII from 744151-744153,744288-744851, Verified ORF, "Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes"
>YLR307C-A YLR307C-A SGDID:S000028525, Chr XII from 747111-746848, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YLR307W CDA1 SGDID:S000004298, Chr XII from 745620-746525, Verified ORF, "Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall"
>YLR308W CDA2 SGDID:S000004299, Chr XII from 747937-748875, Verified ORF, "Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall"
>YLR309C IMH1 SGDID:S000004300, Chr XII from 751769-749034, reverse complement, Verified ORF, "Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi"
>YLR310C CDC25 SGDID:S000004301, Chr XII from 756993-752224, reverse complement, Verified ORF, "Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1"
>YLR311C YLR311C SGDID:S000004302, Chr XII from 757612-757265, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YLR312C YLR312C SGDID:S000004303, Chr XII from 758833-757637, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YLR312W-A MRPL15 SGDID:S000004304, Chr XII from 759480-760241, Verified ORF, "Mitochondrial ribosomal protein of the large subunit"
>YLR313C SPH1 SGDID:S000004305, Chr XII from 762342-760750, reverse complement, Verified ORF, "Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p"
>YLR314C CDC3 SGDID:S000004306, Chr XII from 764137-762575, reverse complement, Verified ORF, "Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM"
>YLR315W NKP2 SGDID:S000004307, Chr XII from 764808-765269, Verified ORF, "Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p)"
>YLR316C TAD3 SGDID:S000004308, Chr XII from 766073-765266,766181-766130,766358-766250, reverse complement, Verified ORF, "Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs"
>YLR317W YLR317W SGDID:S000004309, Chr XII from 765655-766089, Dubious ORF, "Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C"
>YLR318W EST2 SGDID:S000004310, Chr XII from 766542-769196, Verified ORF, "Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia"
>YLR319C BUD6 SGDID:S000004311, Chr XII from 771684-769318, reverse complement, Verified ORF, "Actin- and formin-interacting protein, involved in actin cable nucleation and polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate"
>YLR320W MMS22 SGDID:S000004312, Chr XII from 771940-776304, Verified ORF, "Protein that acts with Mms1p in a repair pathway that may be involved in resolving replication intermediates or preventing the damage caused by blocked replication forks; required for accurate meiotic chromosome segregation"
>YLR321C SFH1 SGDID:S000004313, Chr XII from 777864-776584, reverse complement, Verified ORF, "Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog"
>YLR322W VPS65 SGDID:S000004314, Chr XII from 777628-777942, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 75% of ORF overlaps the verified gene SFH1; deletion causes a vacuolar protein sorting defect and blocks anaerobic growth"
>YLR323C CWC24 SGDID:S000004315, Chr XII from 778952-778173, reverse complement, Verified ORF, "Essential protein, component of a complex containing Cef1p; has similarity to S. pombe Cwf24p"
>YLR324W PEX30 SGDID:S000004316, Chr XII from 779215-780786, Verified ORF, "Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p"
>YLR325C RPL38 SGDID:S000004317, Chr XII from 781379-781143, reverse complement, Verified ORF, "Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein"
>YLR326W YLR326W SGDID:S000004318, Chr XII from 782174-782896, Uncharacterized ORF, "Putative protein of unknown function, predicted to be palmitoylated"
>YLR327C TMA10 SGDID:S000004319, Chr XII from 783387-783127, reverse complement, Verified ORF, "Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p"
>YLR328W NMA1 SGDID:S000004320, Chr XII from 784913-786118, Verified ORF, "Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways"
>YLR329W REC102 SGDID:S000004321, Chr XII from 786442-786615,786713-787333, Verified ORF, "Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination"
>YLR330W CHS5 SGDID:S000004322, Chr XII from 787664-789679, Verified ORF, "Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane"
>YLR331C JIP3 SGDID:S000004323, Chr XII from 791046-790669, reverse complement, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2"
>YLR332W MID2 SGDID:S000004324, Chr XII from 790676-791806, Verified ORF, "O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p"
>YLR333C RPS25B SGDID:S000004325, Chr XII from 795899-795573, reverse complement, Verified ORF, "Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Ap and has similarity to rat S25 ribosomal protein"
>YLR334C YLR334C SGDID:S000004326, Chr XII from 797078-796698, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here"
>YLR335W NUP2 SGDID:S000004327, Chr XII from 797430-799592, Verified ORF, "Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization"
>YLR336C SGD1 SGDID:S000004328, Chr XII from 802396-799697, reverse complement, Verified ORF, "Essential nuclear protein, required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia"
>YLR337C VRP1 SGDID:S000004329, Chr XII from 805106-802653, reverse complement, Verified ORF, "Proline-rich actin-associated protein involved in cytoskeletal organization and cytokinesis; related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP)"
>YLR338W OPI9 SGDID:S000004330, Chr XII from 804346-805203, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C"
>YLR339C YLR339C SGDID:S000004331, Chr XII from 806335-805784, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0"
>YLR340W RPP0 SGDID:S000004332, Chr XII from 805887-806825, Verified ORF, "Conserved ribosomal protein P0 of the ribosomal stalk, which is involved in interaction between translational elongation factors and the ribosome; similar to rat P0, human P0, and E. coli L10e; phosphorylated on serine 302"
>YLR341W SPO77 SGDID:S000004333, Chr XII from 807385-808818, Verified ORF, "Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis"
>YLR342W FKS1 SGDID:S000004334, Chr XII from 809997-815627, Verified ORF, "Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling"
>YLR342W-A YLR342W-A SGDID:S000028571, Chr XII from 815810-815983, Uncharacterized ORF, "Putative protein of unknown function"
>YLR343W GAS2 SGDID:S000004335, Chr XII from 816094-817761, Verified ORF, "1,3-beta-glucanosyltransferase, involved with Gas4p in spore wall assembly; has similarity to Gas1p"
>YLR344W RPL26A SGDID:S000004336, Chr XII from 819312-819330,819778-820142, Verified ORF, "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Bp and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA"
>YLR345W YLR345W SGDID:S000004337, Chr XII from 820511-822040, Uncharacterized ORF, "Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene"
>YLR346C YLR346C SGDID:S000004338, Chr XII from 822592-822287, reverse complement, Uncharacterized ORF, "Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene"
>YLR347C KAP95 SGDID:S000004339, Chr XII from 826413-823828, reverse complement, Verified ORF, "Karyopherin beta, forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p"
>YLR347W-A YLR347W-A SGDID:S000028681, Chr XII from 824789-824929, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF KAP95/YLR347C"
>YLR348C DIC1 SGDID:S000004340, Chr XII from 827873-826977, reverse complement, Verified ORF, "Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix"
>YLR349W YLR349W SGDID:S000004341, Chr XII from 827521-828027, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C"
>YLR350W ORM2 SGDID:S000004342, Chr XII from 828730-829380, Verified ORF, "Evolutionarily conserved protein, similar to Orm1p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control"
>YLR351C NIT3 SGDID:S000004343, Chr XII from 830364-829489, reverse complement, Verified ORF, "Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member"
>YLR352W YLR352W SGDID:S000004344, Chr XII from 831116-833539, Uncharacterized ORF, "Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene"
>YLR353W BUD8 SGDID:S000004345, Chr XII from 834352-836163, Verified ORF, "Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole"
>YLR354C TAL1 SGDID:S000004346, Chr XII from 837357-836350, reverse complement, Verified ORF, "Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate"
>YLR355C ILV5 SGDID:S000004347, Chr XII from 839253-838066, reverse complement, Verified ORF, "Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA and found in mitochondrial nucleoids"
>YLR356W ATG33 SGDID:S000004348, Chr XII from 840321-840914, Verified ORF, "Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes"
>YLR357W RSC2 SGDID:S000004349, Chr XII from 841331-844000, Verified ORF, "Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance"
>YLR358C YLR358C SGDID:S000004350, Chr XII from 844050-843487, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSC2/YLR357W"
>YLR359W ADE13 SGDID:S000004351, Chr XII from 844282-845730, Verified ORF, "Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency"
>YLR360W VPS38 SGDID:S000004352, Chr XII from 846103-847422, Verified ORF, "Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity"
>YLR361C DCR2 SGDID:S000004353, Chr XII from 849124-847388, reverse complement, Verified ORF, "Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START"
>YLR361C-A YLR361C-A SGDID:S000028845, Chr XII from 849679-849383, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YLR362W STE11 SGDID:S000004354, Chr XII from 849866-852019, Verified ORF, "Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p"
>YLR363C NMD4 SGDID:S000004355, Chr XII from 853151-852495, reverse complement, Verified ORF, "Protein interacting with Nam7p, may be involved in the nonsense-mediated mRNA decay pathway"
>YLR363W-A YLR363W-A SGDID:S000007620, Chr XII from 853461-853718, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus"
>YLR364C-A YLR364C-A SGDID:S000028846, Chr XII from 855645-855523, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR366W"
>YLR364W GRX8 SGDID:S000004356, Chr XII from 854062-854391, Verified ORF, "Glutaredoxin that employs a dithiol mechanism of catalysis; monomeric; activity is low and null mutation does not affect sensitivity to oxidative stress; GFP-fusion protein localizes to the cytoplasm; expression strongly induced by arsenic"
>YLR365W YLR365W SGDID:S000004357, Chr XII from 855199-855531, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene"
>YLR366W YLR366W SGDID:S000004358, Chr XII from 855538-855843, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A"
>YLR367W RPS22B SGDID:S000004359, Chr XII from 856442-856574,857058-857317, Verified ORF, "Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Ap and has similarity to E. coli S8 and rat S15a ribosomal proteins"
>YLR368W MDM30 SGDID:S000004360, Chr XII from 857540-859336, Verified ORF, "F-box protein; associates with mitochondria and has a role in mitochondrial fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains"
>YLR369W SSQ1 SGDID:S000004361, Chr XII from 859552-861525, Verified ORF, "Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia"
>YLR370C ARC18 SGDID:S000004362, Chr XII from 862254-861718, reverse complement, Verified ORF, "Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches"
>YLR371W ROM2 SGDID:S000004363, Chr XII from 862714-866784, Verified ORF, "GDP/GTP exchange protein (GEP) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEP"
>YLR372W SUR4 SGDID:S000004364, Chr XII from 867354-868391, Verified ORF, "Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis"
>YLR373C VID22 SGDID:S000004365, Chr XII from 871367-868662, reverse complement, Verified ORF, "Glycosylated integral membrane protein localized to the plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles"
>YLR374C YLR374C SGDID:S000004366, Chr XII from 871842-871453, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W"
>YLR375W STP3 SGDID:S000004367, Chr XII from 871697-872728, Verified ORF, "Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids"
>YLR376C PSY3 SGDID:S000004368, Chr XII from 873554-872826, reverse complement, Verified ORF, "Protein involved in a Rad51p-, Rad54p-dependent pathway for homologous recombination repair; deletion results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C"
>YLR377C FBP1 SGDID:S000004369, Chr XII from 874792-873746, reverse complement, Verified ORF, "Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; interacts with Vid30p"
>YLR378C SEC61 SGDID:S000004370, Chr XII from 877178-875736, reverse complement, Verified ORF, "Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER"
>YLR379W YLR379W SGDID:S000004371, Chr XII from 876922-877296, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential ORF SEC61/YLR378C"
>YLR380W CSR1 SGDID:S000004372, Chr XII from 878282-879508, Verified ORF, "Phosphatidylinositol transfer protein with a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance"
>YLR381W CTF3 SGDID:S000004373, Chr XII from 879723-881924, Verified ORF, "Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules"
>YLR382C NAM2 SGDID:S000004374, Chr XII from 884751-882067, reverse complement, Verified ORF, "Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance"
>YLR383W SMC6 SGDID:S000004375, Chr XII from 885288-888632, Verified ORF, "Protein involved in structural maintenance of chromosomes; essential subunit of Mms21-Smc5-Smc6 complex; required for growth, DNA repair, interchromosomal and sister chromatid recombination; homologous to S. pombe rad18"
>YLR384C IKI3 SGDID:S000004376, Chr XII from 892900-888851, reverse complement, Verified ORF, "Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)"
>YLR385C SWC7 SGDID:S000004377, Chr XII from 893390-892992, reverse complement, Verified ORF, "Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin"
>YLR386W VAC14 SGDID:S000004378, Chr XII from 893628-896270, Verified ORF, "Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p"
>YLR387C REH1 SGDID:S000004379, Chr XII from 897672-896374, reverse complement, Verified ORF, "Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains"
>YLR388W RPS29A SGDID:S000004380, Chr XII from 898651-898821, Verified ORF, "Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Bp and has similarity to rat S29 and E. coli S14 ribosomal proteins"
>YLR389C STE23 SGDID:S000004381, Chr XII from 902660-899577, reverse complement, Verified ORF, "Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; expressed in both haploids and diploids; member of the insulin-degrading enzyme family"
>YLR390W ECM19 SGDID:S000004382, Chr XII from 903066-903404, Verified ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YLR390W-A CCW14 SGDID:S000006429, Chr XII from 903724-904440, Verified ORF, "Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall"
>YLR392C ART10 SGDID:S000004384, Chr XII from 906305-904749, reverse complement, Verified ORF, "Protein of unknown function that contains 2 PY motifs and is ubiquinated by Rsp5p; green fluorescent protein (GFP)-fusion protein localizes it to the cytoplasm; non-essential gene"
>YLR393W ATP10 SGDID:S000004385, Chr XII from 907079-907918, Verified ORF, "Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6"
>YLR394W CST9 SGDID:S000004386, Chr XII from 907950-909398, Verified ORF, "SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate"
>YLR395C COX8 SGDID:S000004387, Chr XII from 909965-909729, reverse complement, Verified ORF, "Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain"
>YLR396C VPS33 SGDID:S000004388, Chr XII from 912310-910235, reverse complement, Verified ORF, "ATP-binding protein that is a subunit of the HOPS complex and of the CORVET tethering complex; essential for protein sorting, vesicle docking and fusion at the vacuole"
>YLR397C AFG2 SGDID:S000004389, Chr XII from 914892-912550, reverse complement, Verified ORF, "ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; may be involved in degradation of aberrant mRNAs"
>YLR398C SKI2 SGDID:S000004390, Chr XII from 919019-915156, reverse complement, Verified ORF, "Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay"
>YLR399C BDF1 SGDID:S000004391, Chr XII from 921596-919536, reverse complement, Verified ORF, "Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p"
>YLR399W-A YLR399W-A SGDID:S000028682, Chr XII from 920869-920973, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the characterized ORF BDF1/YLR399C"
>YLR400W YLR400W SGDID:S000004392, Chr XII from 922063-922536, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YLR401C DUS3 SGDID:S000004393, Chr XII from 924448-922442, reverse complement, Verified ORF, "Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region"
>YLR402W YLR402W SGDID:S000004394, Chr XII from 924889-925080, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YLR403W SFP1 SGDID:S000004395, Chr XII from 925568-927619, Verified ORF, "Transcription factor that controls expression of ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, modulates cell size; regulated by TORC1 and Mrs6p"
>YLR404W FLD1 SGDID:S000004396, Chr XII from 928743-929600, Verified ORF, "Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy"
>YLR405W DUS4 SGDID:S000004397, Chr XII from 929789-930892, Verified ORF, "Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p"
>YLR406C RPL31B SGDID:S000004398, Chr XII from 931349-931065,931755-931699, reverse complement, Verified ORF, "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Ap and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality"
>YLR406C-A YLR406C-A SGDID:S000028683, Chr XII from 932355-932206, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YLR407W YLR407W SGDID:S000004399, Chr XII from 932967-933653, Uncharacterized ORF, "Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus"
>YLR408C BLS1 SGDID:S000004400, Chr XII from 934253-933885, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene"
>YLR409C UTP21 SGDID:S000004401, Chr XII from 937233-934414, reverse complement, Verified ORF, "Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma"
>YLR410W VIP1 SGDID:S000004402, Chr XII from 937541-940981, Verified ORF, "Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; IP7 production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1"
>YLR410W-A YLR410W-A SGDID:S000007379, Chr XII from 941483-942799, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YLR410W-B YLR410W-B SGDID:S000007380, Chr XII from 941483-942775,942777-946796, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YLR411W CTR3 SGDID:S000004403, Chr XII from 947253-947978, Verified ORF, "High-affinity copper transporter of the plasma membrane, acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae"
>YLR412C-A YLR412C-A SGDID:S000028572, Chr XII from 950473-950267, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YLR412W BER1 SGDID:S000004404, Chr XII from 948368-949192, Verified ORF, "Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene"
>YLR413W YLR413W SGDID:S000004405, Chr XII from 951156-953183, Uncharacterized ORF, "Putative protein of unknown function; YLR413W is not an essential gene"
>YLR414C PUN1 SGDID:S000004406, Chr XII from 954144-953353, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; localizes to bud and cytoplasm; co-localizes with Sur7p in punctate patches in the plasma membrane; null mutant displays decreased thermotolerance; transcription induced on cell wall damage"
>YLR415C YLR415C SGDID:S000004407, Chr XII from 954597-954259, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; YLR415C is not an essential gene"
>YLR416C YLR416C SGDID:S000004408, Chr XII from 954889-954491, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YLR417W VPS36 SGDID:S000004409, Chr XII from 955010-956710, Verified ORF, "Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome"
>YLR418C CDC73 SGDID:S000004410, Chr XII from 958095-956914, reverse complement, Verified ORF, "Component of the Paf1p complex that binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance"
>YLR419W YLR419W SGDID:S000004411, Chr XII from 958428-962735, Uncharacterized ORF, "Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene"
>YLR420W URA4 SGDID:S000004412, Chr XII from 963785-964879, Verified ORF, "Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate"
>YLR421C RPN13 SGDID:S000004413, Chr XII from 965560-965090, reverse complement, Verified ORF, "Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability"
>YLR422W YLR422W SGDID:S000004414, Chr XII from 965897-971695, Uncharacterized ORF, "Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein"
>YLR423C ATG17 SGDID:S000004415, Chr XII from 973170-971917, reverse complement, Verified ORF, "Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity"
>YLR424W SPP382 SGDID:S000004416, Chr XII from 973395-975521, Verified ORF, "Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation"
>YLR425W TUS1 SGDID:S000004417, Chr XII from 982894-986817, Verified ORF, "Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate"
>YLR426W YLR426W SGDID:S000004418, Chr XII from 987062-987141,987213-988113, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin"
>YLR427W MAG2 SGDID:S000004419, Chr XII from 988428-990440, Verified ORF, "Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1"
>YLR428C YLR428C SGDID:S000004420, Chr XII from 990961-990617, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1"
>YLR429W CRN1 SGDID:S000004421, Chr XII from 990777-992732, Verified ORF, "Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly"
>YLR430W SEN1 SGDID:S000004422, Chr XII from 993434-1000129, Verified ORF, "Presumed helicase required for RNA polymerase II transcription termination and processing of RNAs; homolog of Senataxin which causes Ataxia-Oculomotor Apraxia 2 and a dominant form of amyotrophic lateral sclerosis"
>YLR431C ATG23 SGDID:S000004423, Chr XII from 1001703-1000342, reverse complement, Verified ORF, "Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p"
>YLR432W IMD3 SGDID:S000004424, Chr XII from 1002557-1004128, Verified ORF, "Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed"
>YLR433C CNA1 SGDID:S000004425, Chr XII from 1006008-1004347, reverse complement, Verified ORF, "Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1"
>YLR434C YLR434C SGDID:S000004426, Chr XII from 1006408-1006025, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W"
>YLR435W TSR2 SGDID:S000004427, Chr XII from 1006378-1006995, Verified ORF, "Protein with a potential role in pre-rRNA processing"
>YLR436C ECM30 SGDID:S000004428, Chr XII from 1011245-1007421, reverse complement, Verified ORF, "Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm"
>YLR437C DIF1 SGDID:S000004429, Chr XII from 1012023-1011622, reverse complement, Verified ORF, "Protein that regulates the nuclear localization of ribonucleotide reductase Rnr2p and Rnr4p subunits; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half has similarity to S. pombe Spd1 protein"
>YLR437C-A YLR437C-A SGDID:S000028684, Chr XII from 1012686-1012459, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CAR2/YLR438W"
>YLR438C-A LSM3 SGDID:S000006434, Chr XII from 1014178-1013909, reverse complement, Verified ORF, "Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA"
>YLR438W CAR2 SGDID:S000004430, Chr XII from 1012501-1013775, Verified ORF, "L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive"
>YLR439W MRPL4 SGDID:S000004431, Chr XII from 1014491-1015450, Verified ORF, "Mitochondrial ribosomal protein of the large subunit"
>YLR440C SEC39 SGDID:S000004432, Chr XII from 1017697-1015568, reverse complement, Verified ORF, "Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope"
>YLR441C RPS1A SGDID:S000004433, Chr XII from 1018908-1018141, reverse complement, Verified ORF, "Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Bp and has similarity to rat S3a ribosomal protein"
>YLR442C SIR3 SGDID:S000004434, Chr XII from 1022251-1019315, reverse complement, Verified ORF, "Silencing protein that interacts with Sir2p and Sir4p, and histone H3 and H4 tails, to establish a transcriptionally silent chromatin state; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p"
>YLR443W ECM7 SGDID:S000004435, Chr XII from 1022625-1023971, Verified ORF, "Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency"
>YLR444C YLR444C SGDID:S000004436, Chr XII from 1023988-1023686, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YLR445W YLR445W SGDID:S000004437, Chr XII from 1024189-1024572,1024655-1024837, Uncharacterized ORF, "Putative protein of unknown function; transcription is regulated by Ume6p and induced in response to alpha factor"
>YLR446W YLR446W SGDID:S000004438, Chr XII from 1025214-1026515, Uncharacterized ORF, "Putative protein of unknown function with similarity to hexokinases; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene"
>YLR447C VMA6 SGDID:S000004439, Chr XII from 1027893-1026856, reverse complement, Verified ORF, "Subunit d of the five-subunit V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found in the endomembrane system; stabilizes VO subunits; required for V1 domain assembly on the vacuolar membrane"
>YLR448W RPL6B SGDID:S000004440, Chr XII from 1028854-1028868,1029253-1029768, Verified ORF, "Protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Ap and to rat L6 ribosomal protein; binds to 5.8S rRNA"
>YLR449W FPR4 SGDID:S000004441, Chr XII from 1030834-1032012, Verified ORF, "Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones"
>YLR450W HMG2 SGDID:S000004442, Chr XII from 1032627-1035764, Verified ORF, "One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks"
>YLR451W LEU3 SGDID:S000004443, Chr XII from 1036093-1038753, Verified ORF, "Zinc-finger transcription factor that regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; positively regulated by alpha-isopropylmalate, an intermediate in leucine biosynthesis"
>YLR452C SST2 SGDID:S000004444, Chr XII from 1041366-1039270, reverse complement, Verified ORF, "GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family"
>YLR453C RIF2 SGDID:S000004445, Chr XII from 1042986-1041799, reverse complement, Verified ORF, "Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation"
>YLR454W FMP27 SGDID:S000004446, Chr XII from 1043998-1051884, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YLR455W YLR455W SGDID:S000004447, Chr XII from 1053629-1054543, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)"
>YLR456W YLR456W SGDID:S000004448, Chr XII from 1055070-1055684, Uncharacterized ORF, "Putative protein of unknown function; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2"
>YLR457C NBP1 SGDID:S000004449, Chr XII from 1056771-1055812, reverse complement, Verified ORF, "Spindle pole body (SPB) component, required for the insertion of the duplication plaque into the nuclear membrane during SPB duplication; essential for bipolar spindle formation; component of the Mps2p-Bbp1p complex"
>YLR458W YLR458W SGDID:S000004450, Chr XII from 1056455-1056835, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis"
>YLR459W GAB1 SGDID:S000004451, Chr XII from 1057334-1058518, Verified ORF, "GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI"
>YLR460C YLR460C SGDID:S000004452, Chr XII from 1060887-1059757, reverse complement, Uncharacterized ORF, "Member of the quinone oxidoreductase family, up-regulated in response to the fungicide mancozeb; possibly up-regulated by iodine"
>YLR461W PAU4 SGDID:S000004453, Chr XII from 1062919-1063281, Verified ORF, "Member of the seripauperin multigene family encoded mainly in subtelomeric regions; active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme"
>YLR462W YLR462W SGDID:S000004454, Chr XII from 1065956-1066564, Uncharacterized ORF, "Putative protein of unknown function with similarity to helicases; YLR462W is within the telomere on the right arm of chromosome XII"
>YLR463C YLR463C SGDID:S000004455, Chr XII from 1066816-1066265, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORFs YLR462W and YLR464W"
>YLR464W YLR464W SGDID:S000004456, Chr XII from 1066572-1067084,1067364-1067501, Uncharacterized ORF, "Putative protein of unknown function; intron is predicted but not detected experimentally; YLR464W overlaps the verified gene YRF1-4/YLR466W and two dubious ORFs YLR463C and YLR465C"
>YLR465C BSC3 SGDID:S000004457, Chr XII from 1067353-1067045, reverse complement, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 100% of YLR465C overlaps the uncharacterized ORF YLR464W and 86% of YLR465C overlaps the verified gene YRF1-4"
>YLR466C-A YLR466C-A SGDID:S000028685, Chr XII from 1070869-1070387, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YRF1-4/YLR466W"
>YLR466C-B YLR466C-B SGDID:S000028686, Chr XII from 1071710-1071594, reverse complement, Uncharacterized ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YLR466W YRF1-4 SGDID:S000004458, Chr XII from 1067087-1071235, Verified ORF, "Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p"
>YLR467C-A YLR467C-A SGDID:S000028687, Chr XII from 1077532-1077050, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YRF1-4/YLR466W"
>YLR467W YRF1-5 SGDID:S000004459, Chr XII from 1072508-1077898, Verified ORF, "Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p"
>YML001W YPT7 SGDID:S000004460, Chr XIII from 267174-267800, Verified ORF, "Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion, similar to mammalian Rab7"
>YML002W YML002W SGDID:S000004461, Chr XIII from 264541-266754, Uncharacterized ORF, "Putative protein of unknown function; expression induced by heat and by calcium shortage"
>YML003W YML003W SGDID:S000004462, Chr XIII from 263483-264355, Uncharacterized ORF, "Putative protein of unknown function"
>YML004C GLO1 SGDID:S000004463, Chr XIII from 262685-261705, reverse complement, Verified ORF, "Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress"
>YML005W TRM12 SGDID:S000004464, Chr XIII from 260221-261609, Verified ORF, "S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA"
>YML006C GIS4 SGDID:S000004465, Chr XIII from 258416-256092, reverse complement, Verified ORF, "CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway"
>YML007C-A YML007C-A SGDID:S000007621, Chr XIII from 253272-253162, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria"
>YML007W YAP1 SGDID:S000004466, Chr XIII from 253848-255800, Verified ORF, "Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; mediates resistance to cadmium"
>YML008C ERG6 SGDID:S000004467, Chr XIII from 252990-251839, reverse complement, Verified ORF, "Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to both lipid particles and mitochondrial outer membrane"
>YML009C MRPL39 SGDID:S000004468, Chr XIII from 251516-251304, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the large subunit"
>YML009C-A YML009C-A SGDID:S000004469, Chr XIII from 251001-250675, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YML009W-B YML009W-B SGDID:S000004471, Chr XIII from 250435-250911, Dubious ORF, "Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition"
>YML010W SPT5 SGDID:S000004470, Chr XIII from 247677-250868, Verified ORF, "Protein involved in regulating Pol I and Pol II transcription and pre-mRNA processing; forms a complex with Spt4p; contains a C-terminal repeat domain that is a target for phosphorylation by Sgv1p"
>YML011C RAD33 SGDID:S000004472, Chr XIII from 247428-246895, reverse complement, Verified ORF, "Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus"
>YML012C-A YML012C-A SGDID:S000004474, Chr XIII from 245914-245537, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SEL1"
>YML012W ERV25 SGDID:S000004473, Chr XIII from 246116-246751, Verified ORF, "Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport"
>YML013W UBX2 SGDID:S000004475, Chr XIII from 244149-245903, Verified ORF, "Protein involved in ER-associated protein degradation; proposed to coordinate the assembly of proteins involved in ERAD; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain"
>YML014W TRM9 SGDID:S000004476, Chr XIII from 243225-244064, Verified ORF, "tRNA methyltransferase, catalyzes esterification of modified uridine nucleotides in tRNA(Arg3) and tRNA(Glu), likely as part of a complex with Trm112p; deletion confers resistance to zymocin"
>YML015C TAF11 SGDID:S000004477, Chr XIII from 243029-241989, reverse complement, Verified ORF, "TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors"
>YML016C PPZ1 SGDID:S000004478, Chr XIII from 241536-239458, reverse complement, Verified ORF, "Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance"
>YML017W PSP2 SGDID:S000004479, Chr XIII from 236588-236591,236954-238731, Verified ORF, "Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing"
>YML018C YML018C SGDID:S000004480, Chr XIII from 235952-234771, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene"
>YML019W OST6 SGDID:S000004481, Chr XIII from 233457-234455, Verified ORF, "Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p"
>YML020W YML020W SGDID:S000004482, Chr XIII from 231149-233143, Uncharacterized ORF, "Putative protein of unknown function"
>YML021C UNG1 SGDID:S000004483, Chr XIII from 230813-229734, reverse complement, Verified ORF, "Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus"
>YML022W APT1 SGDID:S000004484, Chr XIII from 228937-229500, Verified ORF, "Adenine phosphoribosyltransferase, catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis"
>YML023C NSE5 SGDID:S000004485, Chr XIII from 228664-226994, reverse complement, Verified ORF, "Essential subunit of the Mms21-Smc5-Smc6 complex; required for cell viability and DNA repair"
>YML024W RPS17A SGDID:S000004486, Chr XIII from 225889-225891,226290-226697, Verified ORF, "Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Bp and has similarity to rat S17 ribosomal protein"
>YML025C YML6 SGDID:S000004487, Chr XIII from 225239-224406,225365-225339, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins"
>YML026C RPS18B SGDID:S000004488, Chr XIII from 223380-222987,223828-223782, reverse complement, Verified ORF, "Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins"
>YML027W YOX1 SGDID:S000004489, Chr XIII from 221406-222563, Verified ORF, "Homeodomain-containing transcriptional repressor, binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate"
>YML028W TSA1 SGDID:S000004490, Chr XIII from 220138-220728, Verified ORF, "Thioredoxin peroxidase, acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype"
>YML029W USA1 SGDID:S000004491, Chr XIII from 217362-219878, Verified ORF, "Protein involved in ER-associated protein degradation (ERAD); component of the Hrd1p complex; interacts with the U1 snRNP-specific protein, Snp1p"
>YML030W AIM31 SGDID:S000004492, Chr XIII from 216435-216914, Verified ORF, "Putative protein of unknown function; GFP-fusion protein localizes to mitochondria; may interact with respiratory chain complexes III or IV; null mutant is viable and displays reduced frequency of mitochondrial genome loss"
>YML031C-A YML031C-A SGDID:S000028809, Chr XIII from 214421-214086, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF NDC1/YML031W; questionable ORF from MIPS"
>YML031W NDC1 SGDID:S000004493, Chr XIII from 214189-216156, Verified ORF, "Nuclear envelope protein with multiple putative transmembrane domains, required for nuclear pore complex assembly and spindle pole body duplication; required for meiosis II"
>YML032C RAD52 SGDID:S000004494, Chr XIII from 213930-212515, reverse complement, Verified ORF, "Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis"
>YML034C-A YML034C-A SGDID:S000004499, Chr XIII from 209826-209428, reverse complement, Dubious ORF, "Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YML034W SRC1 SGDID:S000004497, Chr XIII from 209525-211444,211571-212155, Verified ORF, "Inner nuclear membrane protein that functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; mutant has aneuploidy tolerance"
>YML035C AMD1 SGDID:S000004498, Chr XIII from 208860-206428, reverse complement, Verified ORF, "AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may be involved in regulation of intracellular adenine nucleotide pools"
>YML036W CGI121 SGDID:S000004500, Chr XIII from 205642-206097,206204-206293, Verified ORF, "Protein involved in telomere uncapping and elongation as component of the KEOPS protein complex with Bud32p, Kae1p, Pcc1p, and Gon7p; also shown to be a component of the EKC protein complex; homolog of human CGI-121"
>YML037C YML037C SGDID:S000004501, Chr XIII from 205408-204386, reverse complement, Uncharacterized ORF, "Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene"
>YML038C YMD8 SGDID:S000004502, Chr XIII from 204103-202775, reverse complement, Verified ORF, "Putative nucleotide sugar transporter, has similarity to Vrg4p"
>YML039W YML039W SGDID:S000004503, Chr XIII from 196628-197932,197934-201896, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YML040W YML040W SGDID:S000004504, Chr XIII from 196628-197950, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YML041C VPS71 SGDID:S000004505, Chr XIII from 195755-194913, reverse complement, Verified ORF, "Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting"
>YML042W CAT2 SGDID:S000004506, Chr XIII from 192788-194800, Verified ORF, "Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes"
>YML043C RRN11 SGDID:S000004507, Chr XIII from 191767-190244, reverse complement, Verified ORF, "Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p"
>YML045W YML045W SGDID:S000004508, Chr XIII from 184461-185765,185767-189729, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YML045W-A YML045W-A SGDID:S000007381, Chr XIII from 184461-185783, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YML046W PRP39 SGDID:S000004509, Chr XIII from 181474-183363, Verified ORF, "U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats"
>YML047C PRM6 SGDID:S000004510, Chr XIII from 181075-180017, reverse complement, Verified ORF, "Pheromone-regulated protein, predicted to have 2 transmembrane segments; regulated by Ste12p during mating"
>YML047W-A YML047W-A SGDID:S000004512, Chr XIII from 179893-180258, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YML048W GSF2 SGDID:S000004511, Chr XIII from 178426-179637, Verified ORF, "ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression"
>YML049C RSE1 SGDID:S000004513, Chr XIII from 178305-174220, reverse complement, Verified ORF, "Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport"
>YML050W AIM32 SGDID:S000004514, Chr XIII from 173139-174074, Verified ORF, "Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss"
>YML051W GAL80 SGDID:S000004515, Chr XIII from 171594-172901, Verified ORF, "Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding"
>YML052W SUR7 SGDID:S000004516, Chr XIII from 170402-171310, Verified ORF, "Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants"
>YML053C YML053C SGDID:S000004517, Chr XIII from 169754-169116, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene"
>YML054C CYB2 SGDID:S000004518, Chr XIII from 167308-165533, reverse complement, Verified ORF, "Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions"
>YML054C-A YML054C-A SGDID:S000028573, Chr XIII from 167781-167623, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YML055W SPC2 SGDID:S000004519, Chr XIII from 164790-165326, Verified ORF, "Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25"
>YML056C IMD4 SGDID:S000004520, Chr XIII from 163308-162194,164176-163717, reverse complement, Verified ORF, "Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed"
>YML057C-A YML057C-A SGDID:S000004522, Chr XIII from 160412-160023, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene CMP2/YML057W"
>YML057W CMP2 SGDID:S000004521, Chr XIII from 160180-161994, Verified ORF, "Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1"
>YML058W SML1 SGDID:S000004523, Chr XIII from 159383-159697, Verified ORF, "Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase"
>YML058W-A HUG1 SGDID:S000007472, Chr XIII from 158760-158966, Verified ORF, "Protein involved in the Mec1p-mediated checkpoint pathway that responds to DNA damage or replication arrest, transcription is induced by DNA damage"
>YML059C NTE1 SGDID:S000004524, Chr XIII from 158258-153219, reverse complement, Verified ORF, "Serine esterase, homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes"
>YML060W OGG1 SGDID:S000004525, Chr XIII from 151871-153001, Verified ORF, "Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance"
>YML061C PIF1 SGDID:S000004526, Chr XIII from 151532-148953, reverse complement, Verified ORF, "DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis"
>YML062C MFT1 SGDID:S000004527, Chr XIII from 148683-147505, reverse complement, Verified ORF, "Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance"
>YML063W RPS1B SGDID:S000004528, Chr XIII from 146482-147249, Verified ORF, "Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein"
>YML064C TEM1 SGDID:S000004529, Chr XIII from 145876-145139, reverse complement, Verified ORF, "GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis"
>YML065W ORC1 SGDID:S000004530, Chr XIII from 142210-144954, Verified ORF, "Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity"
>YML066C SMA2 SGDID:S000004531, Chr XIII from 141533-140424, reverse complement, Verified ORF, "Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation"
>YML067C ERV41 SGDID:S000004532, Chr XIII from 140090-139063,140214-140184, reverse complement, Verified ORF, "Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein"
>YML068W ITT1 SGDID:S000004533, Chr XIII from 137550-138944, Verified ORF, "Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins"
>YML069W POB3 SGDID:S000004534, Chr XIII from 135500-137158, Verified ORF, "Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases"
>YML070W DAK1 SGDID:S000004535, Chr XIII from 133475-135229, Verified ORF, "Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation"
>YML071C COG8 SGDID:S000004536, Chr XIII from 131572-129749, reverse complement, Verified ORF, "Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments"
>YML072C TCB3 SGDID:S000004537, Chr XIII from 129367-124730, reverse complement, Verified ORF, "Lipid-binding protein, localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interact"
>YML073C RPL6A SGDID:S000004538, Chr XIII from 123742-123227,124172-124158, reverse complement, Verified ORF, "N-terminally acetylated protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Bp and to rat L6 ribosomal protein; binds to 5.8S rRNA"
>YML074C FPR3 SGDID:S000004539, Chr XIII from 121324-120089, reverse complement, Verified ORF, "Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p"
>YML075C HMG1 SGDID:S000004540, Chr XIII from 118898-115734, reverse complement, Verified ORF, "One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae"
>YML076C WAR1 SGDID:S000004541, Chr XIII from 115347-112513, reverse complement, Verified ORF, "Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively"
>YML077W BET5 SGDID:S000004542, Chr XIII from 111865-112344, Verified ORF, "Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi"
>YML078W CPR3 SGDID:S000004543, Chr XIII from 111002-111550, Verified ORF, "Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria"
>YML079W YML079W SGDID:S000004544, Chr XIII from 110247-110852, Uncharacterized ORF, "Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm"
>YML080W DUS1 SGDID:S000004545, Chr XIII from 108806-110077, Verified ORF, "Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17"
>YML081C-A ATP18 SGDID:S000007247, Chr XIII from 104162-103983, reverse complement, Verified ORF, "Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms"
>YML081W YML081W SGDID:S000004546, Chr XIII from 104777-108532, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YML081w is not an essential gene"
>YML082W YML082W SGDID:S000004547, Chr XIII from 101862-103811, Uncharacterized ORF, "Putative protein predicted to have carbon-sulfur lyase activity; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YNML082W is not an essential gene"
>YML083C YML083C SGDID:S000004548, Chr XIII from 101050-99794, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions"
>YML084W YML084W SGDID:S000004549, Chr XIII from 99489-99797, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YML085C TUB1 SGDID:S000004550, Chr XIII from 99259-97941,99400-99376, reverse complement, Verified ORF, "Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules"
>YML086C ALO1 SGDID:S000004551, Chr XIII from 97371-95791, reverse complement, Verified ORF, "D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress"
>YML087C AIM33 SGDID:S000004552, Chr XIII from 95369-94431, reverse complement, Verified ORF, "Putative protein of unknown function, highly conserved across species and orthologous to human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss"
>YML088W UFO1 SGDID:S000004553, Chr XIII from 92235-94241, Verified ORF, "F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation"
>YML089C YML089C SGDID:S000004554, Chr XIII from 91409-91041, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage"
>YML090W YML090W SGDID:S000004555, Chr XIII from 90744-91130, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source"
>YML091C RPM2 SGDID:S000004556, Chr XIII from 90731-87123, reverse complement, Verified ORF, "Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus"
>YML092C PRE8 SGDID:S000004557, Chr XIII from 86739-85987, reverse complement, Verified ORF, "Alpha 2 subunit of the 20S proteasome"
>YML093W UTP14 SGDID:S000004558, Chr XIII from 83090-85789, Verified ORF, "Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit"
>YML094C-A YML094C-A SGDID:S000004561, Chr XIII from 82620-82219, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO"
>YML094W GIM5 SGDID:S000004559, Chr XIII from 82275-82290,82374-82849, Verified ORF, "Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it"
>YML095C RAD10 SGDID:S000004560, Chr XIII from 82113-81481, reverse complement, Verified ORF, "Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein"
>YML096W YML096W SGDID:S000004562, Chr XIII from 79909-81486, Uncharacterized ORF, "Putative protein of unknown function with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10"
>YML097C VPS9 SGDID:S000004563, Chr XIII from 79690-78335, reverse complement, Verified ORF, "A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin"
>YML098W TAF13 SGDID:S000004564, Chr XIII from 77267-77770, Verified ORF, "TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors"
>YML099C ARG81 SGDID:S000004565, Chr XIII from 77040-74398, reverse complement, Verified ORF, "Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p"
>YML099W-A YML099W-A SGDID:S000004567, Chr XIII from 74229-74558, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF ARG81/YML099C"
>YML100W TSL1 SGDID:S000004566, Chr XIII from 70624-73920, Verified ORF, "Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, similar to Tps3p and may share function; mutant has aneuploidy tolerance"
>YML100W-A YML100W-A SGDID:S000028688, Chr XIII from 70138-70311, Uncharacterized ORF, "Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YML101C CUE4 SGDID:S000004568, Chr XIII from 70088-69735, reverse complement, Verified ORF, "Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination"
>YML101C-A YML101C-A SGDID:S000004569, Chr XIII from 69726-69409, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YML102W CAC2 SGDID:S000004570, Chr XIII from 68294-69700, Verified ORF, "Component of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA, required for building functional kinetochores, conserved from yeast to humans"
>YML103C NUP188 SGDID:S000004571, Chr XIII from 67549-62582, reverse complement, Verified ORF, "Subunit of the nuclear pore complex (NPC), involved in the structural organization of the complex and of the nuclear envelope, also involved in nuclear envelope permeability, interacts with Pom152p and Nic96p"
>YML104C MDM1 SGDID:S000004572, Chr XIII from 62322-58939, reverse complement, Verified ORF, "Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)"
>YML105C SEC65 SGDID:S000004573, Chr XIII from 58687-57866, reverse complement, Verified ORF, "Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19"
>YML106W URA5 SGDID:S000004574, Chr XIII from 56773-57453, Verified ORF, "Major orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; minor OPRTase encoded by URA10"
>YML107C PML39 SGDID:S000004575, Chr XIII from 56269-55265, reverse complement, Verified ORF, "Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes"
>YML108W YML108W SGDID:S000004576, Chr XIII from 54793-55110, Uncharacterized ORF, "Putative protein of unknown function whose structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene"
>YML109W ZDS2 SGDID:S000004577, Chr XIII from 51640-54468, Verified ORF, "Protein with a role in regulating Swe1p-dependent polarized growth; interacts with Cdc55p; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; paralog of Zds1p"
>YML110C COQ5 SGDID:S000004578, Chr XIII from 50954-50031, reverse complement, Verified ORF, "2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes"
>YML111W BUL2 SGDID:S000004579, Chr XIII from 46942-49704, Verified ORF, "Component of the Rsp5p E3-ubiquitin ligase complex, involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions, functional homolog of BUL1"
>YML112W CTK3 SGDID:S000004580, Chr XIII from 45063-45953, Verified ORF, "Gamma subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity"
>YML113W DAT1 SGDID:S000004581, Chr XIII from 44045-44791, Verified ORF, "DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability"
>YML114C TAF8 SGDID:S000004582, Chr XIII from 43575-42043, reverse complement, Verified ORF, "TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation"
>YML115C VAN1 SGDID:S000004583, Chr XIII from 41794-40187, reverse complement, Verified ORF, "Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant"
>YML116W ATR1 SGDID:S000004584, Chr XIII from 38196-39824, Verified ORF, "Multidrug efflux pump of the major facilitator superfamily, required for resistance to aminotriazole and 4-nitroquinoline-N-oxide"
>YML116W-A YML116W-A SGDID:S000004586, Chr XIII from 37472-37774, Dubious ORF, "Putative protein of unknown function"
>YML117W NAB6 SGDID:S000004585, Chr XIII from 34243-37647, Verified ORF, "Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP"
>YML118W NGL3 SGDID:S000004587, Chr XIII from 32334-33851, Verified ORF, "Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p and Ngl2p"
>YML119W YML119W SGDID:S000004588, Chr XIII from 30611-31684, Uncharacterized ORF, "Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate"
>YML120C NDI1 SGDID:S000004589, Chr XIII from 29807-28266, reverse complement, Verified ORF, "NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID"
>YML121W GTR1 SGDID:S000004590, Chr XIII from 26930-27862, Verified ORF, "Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB"
>YML122C YML122C SGDID:S000004591, Chr XIII from 26418-26038, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YML123C PHO84 SGDID:S000004592, Chr XIII from 25800-24037, reverse complement, Verified ORF, "High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p"
>YML124C TUB3 SGDID:S000004593, Chr XIII from 23360-22048,23683-23659, reverse complement, Verified ORF, "Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p"
>YML125C PGA3 SGDID:S000004594, Chr XIII from 21699-20761, reverse complement, Verified ORF, "Putative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking"
>YML126C ERG13 SGDID:S000004595, Chr XIII from 20535-19060, reverse complement, Verified ORF, "3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis"
>YML127W RSC9 SGDID:S000004596, Chr XIII from 17064-18809, Verified ORF, "Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway"
>YML128C MSC1 SGDID:S000004597, Chr XIII from 16676-15135, reverse complement, Verified ORF, "Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated"
>YML129C COX14 SGDID:S000004598, Chr XIII from 14753-14541, reverse complement, Verified ORF, "Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes"
>YML130C ERO1 SGDID:S000004599, Chr XIII from 13174-11483, reverse complement, Verified ORF, "Thiol oxidase required for oxidative protein folding in the endoplasmic reticulum"
>YML131W YML131W SGDID:S000004600, Chr XIII from 10198-11295, Uncharacterized ORF, "Putative protein of unknown function with similarity to medium chain dehydrogenase/reductases; expression induced by stresses including osmotic shock, DNA damaging agents, and other chemicals; GFP-fusion protein localizes to the cytoplasm"
>YML132W COS3 SGDID:S000004601, Chr XIII from 7244-8383, Verified ORF, "Protein involved in salt resistance; interacts with sodium:hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins"
>YML133C YML133C SGDID:S000004602, Chr XIII from 3791-461,4684-3891, reverse complement, Uncharacterized ORF, "Putative protein of unknown function with similarity to helicases; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YML133C contains an intron"
>YML133W-A YML133W-A SGDID:S000028689, Chr XIII from 1610-2185, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized ORF YML133C"
>YML133W-B YML133W-B SGDID:S000028690, Chr XIII from 827-1309, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized ORF YML133C"
>YMR001C CDC5 SGDID:S000004603, Chr XIII from 271136-269019, reverse complement, Verified ORF, "Polo-like kinase with multiple functions in mitosis and cytokinesis through substrate phosphorylation, also functions in adaptation to DNA damage during meiosis; has similarity to Xenopus Plx1 and S. pombe Plo1p; possible Cdc28p substrate"
>YMR001C-A YMR001C-A SGDID:S000028691, Chr XIII from 271577-271347, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YMR002W MIC17 SGDID:S000004604, Chr XIII from 272193-272663, Verified ORF, "Mitochondrial intermembrane space protein, required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs"
>YMR003W AIM34 SGDID:S000004605, Chr XIII from 273118-273714, Verified ORF, "Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss"
>YMR004W MVP1 SGDID:S000004606, Chr XIII from 274017-275552, Verified ORF, "Protein required for sorting proteins to the vacuole; overproduction of Mvp1p suppresses several dominant VPS1 mutations; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole"
>YMR005W TAF4 SGDID:S000004607, Chr XIII from 276045-277211, Verified ORF, "TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrate"
>YMR006C PLB2 SGDID:S000004608, Chr XIII from 279681-277561, reverse complement, Verified ORF, "Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine"
>YMR007W YMR007W SGDID:S000004609, Chr XIII from 279960-280340, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YMR008C PLB1 SGDID:S000004610, Chr XIII from 282584-280590, reverse complement, Verified ORF, "Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol"
>YMR009W ADI1 SGDID:S000004611, Chr XIII from 284102-284641, Verified ORF, "Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions"
>YMR010W YMR010W SGDID:S000004612, Chr XIII from 285100-286317, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1"
>YMR011W HXT2 SGDID:S000004613, Chr XIII from 288079-289704, Verified ORF, "High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose"
>YMR012W CLU1 SGDID:S000004614, Chr XIII from 291134-294967, Verified ORF, "eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant"
>YMR013C SEC59 SGDID:S000004615, Chr XIII from 296738-295179, reverse complement, Verified ORF, "Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation"
>YMR013C-A YMR013C-A SGDID:S000028847, Chr XIII from 296620-296471, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF SEC59/YML013C"
>YMR013W-A YMR013W-A SGDID:S000007622, Chr XIII from 298311-298391, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the characterized snoRNA gene snR73"
>YMR014W BUD22 SGDID:S000004616, Chr XIII from 298868-300427, Verified ORF, "Protein required for 18S rRNA maturation and small ribosomal subunit biogenesis; cosediments with pre-ribosomal particles; mutation decreases efficiency of +1 Ty1 frameshifting and transposition, and affects budding pattern"
>YMR015C ERG5 SGDID:S000004617, Chr XIII from 302485-300869, reverse complement, Verified ORF, "C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs"
>YMR016C SOK2 SGDID:S000004618, Chr XIII from 305593-303236, reverse complement, Verified ORF, "Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factors"
>YMR017W SPO20 SGDID:S000004619, Chr XIII from 307489-308682, Verified ORF, "Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog"
>YMR018W YMR018W SGDID:S000004620, Chr XIII from 310208-311752, Uncharacterized ORF, "Putative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene"
>YMR019W STB4 SGDID:S000004621, Chr XIII from 312156-315005, Verified ORF, "Protein that binds Sin3p in a two-hybrid assay; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters"
>YMR020W FMS1 SGDID:S000004622, Chr XIII from 315377-316903, Verified ORF, "Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis"
>YMR021C MAC1 SGDID:S000004623, Chr XIII from 318418-317165, reverse complement, Verified ORF, "Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport"
>YMR022W UBC7 SGDID:S000004624, Chr XIII from 318680-319177, Verified ORF, "Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly"
>YMR023C MSS1 SGDID:S000004625, Chr XIII from 321017-319437, reverse complement, Verified ORF, "Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3"
>YMR024W MRPL3 SGDID:S000004626, Chr XIII from 321875-323047, Verified ORF, "Mitochondrial ribosomal protein of the large subunit"
>YMR025W CSI1 SGDID:S000004627, Chr XIII from 323300-324187, Verified ORF, "Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling"
>YMR026C PEX12 SGDID:S000004628, Chr XIII from 325435-324236, reverse complement, Verified ORF, "C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder"
>YMR027W YMR027W SGDID:S000004629, Chr XIII from 325877-327289, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene"
>YMR028W TAP42 SGDID:S000004630, Chr XIII from 327482-328582, Verified ORF, "Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits"
>YMR029C FAR8 SGDID:S000004631, Chr XIII from 330231-328660, reverse complement, Verified ORF, "Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p"
>YMR030W RSF1 SGDID:S000004632, Chr XIII from 330793-331923, Verified ORF, "Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes"
>YMR030W-A YMR030W-A SGDID:S000028574, Chr XIII from 337313-337603, Uncharacterized ORF, "Putative protein of unknown function"
>YMR031C YMR031C SGDID:S000004633, Chr XIII from 334743-332212, reverse complement, Uncharacterized ORF, "Protein of unknown function with similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; possible component of the eisosome"
>YMR031W-A YMR031W-A SGDID:S000004634, Chr XIII from 334709-335035, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C"
>YMR032W HOF1 SGDID:S000004635, Chr XIII from 335298-337307, Verified ORF, "Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p"
>YMR033W ARP9 SGDID:S000004636, Chr XIII from 337788-337817,337904-339277, Verified ORF, "Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation"
>YMR034C YMR034C SGDID:S000004637, Chr XIII from 340722-339418, reverse complement, Uncharacterized ORF, "Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene"
>YMR035W IMP2 SGDID:S000004638, Chr XIII from 341142-341675, Verified ORF, "Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p"
>YMR036C MIH1 SGDID:S000004639, Chr XIII from 343520-341856, reverse complement, Verified ORF, "Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25"
>YMR037C MSN2 SGDID:S000004640, Chr XIII from 346517-344403, reverse complement, Verified ORF, "Transcriptional activator related to Msn4p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression"
>YMR038C CCS1 SGDID:S000004641, Chr XIII from 348260-347511, reverse complement, Verified ORF, "Copper chaperone for superoxide dismutase Sod1p, involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation"
>YMR039C SUB1 SGDID:S000004642, Chr XIII from 349522-348644, reverse complement, Verified ORF, "Transcriptional coactivator, facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes"
>YMR040W YET2 SGDID:S000004643, Chr XIII from 350381-350863, Verified ORF, "Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein"
>YMR041C ARA2 SGDID:S000004644, Chr XIII from 351973-350966, reverse complement, Verified ORF, "NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase"
>YMR042W ARG80 SGDID:S000004645, Chr XIII from 352603-353136, Verified ORF, "Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p"
>YMR043W MCM1 SGDID:S000004646, Chr XIII from 353871-354731, Verified ORF, "Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes"
>YMR044W IOC4 SGDID:S000004647, Chr XIII from 355384-356811, Verified ORF, "Member of a complex (Isw1b) with Isw1p and Ioc2p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PWWP motif"
>YMR045C YMR045C SGDID:S000004648, Chr XIII from 361321-357359,362627-361323, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YMR046C YMR046C SGDID:S000004649, Chr XIII from 362627-361305, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YMR046W-A YMR046W-A SGDID:S000007248, Chr XIII from 362702-362830, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YMR047C NUP116 SGDID:S000004650, Chr XIII from 366705-363364, reverse complement, Verified ORF, "Subunit of the Nup82 subcomplex of the nuclear pore complex; localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup100p"
>YMR048W CSM3 SGDID:S000004651, Chr XIII from 366981-367934, Verified ORF, "Replication fork associated factor, required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis"
>YMR049C ERB1 SGDID:S000004652, Chr XIII from 370517-368094, reverse complement, Verified ORF, "Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1"
>YMR050C YMR050C SGDID:S000004653, Chr XIII from 377019-373057,378325-377021, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YMR051C YMR051C SGDID:S000004654, Chr XIII from 378325-377003, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YMR052C-A YMR052C-A SGDID:S000004655, Chr XIII from 380434-380069, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YMR052W FAR3 SGDID:S000004656, Chr XIII from 379586-380200, Verified ORF, "Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum"
>YMR053C STB2 SGDID:S000004657, Chr XIII from 382898-380346, reverse complement, Verified ORF, "Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p"
>YMR054W STV1 SGDID:S000004658, Chr XIII from 383303-385975, Verified ORF, "Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole"
>YMR055C BUB2 SGDID:S000004659, Chr XIII from 387021-386101, reverse complement, Verified ORF, "Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage"
>YMR056C AAC1 SGDID:S000004660, Chr XIII from 388244-387315, reverse complement, Verified ORF, "Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator"
>YMR057C YMR057C SGDID:S000004661, Chr XIII from 388730-388359, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1"
>YMR058W FET3 SGDID:S000004662, Chr XIII from 388822-390732, Verified ORF, "Ferro-O2-oxidoreductase required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases"
>YMR059W SEN15 SGDID:S000004663, Chr XIII from 391099-391485, Verified ORF, "Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p"
>YMR060C SAM37 SGDID:S000004664, Chr XIII from 392515-391532, reverse complement, Verified ORF, "Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability"
>YMR061W RNA14 SGDID:S000004665, Chr XIII from 392755-394788, Verified ORF, "Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex"
>YMR062C ARG7 SGDID:S000004666, Chr XIII from 396379-395054, reverse complement, Verified ORF, "Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine"
>YMR063W RIM9 SGDID:S000004667, Chr XIII from 397077-397796, Verified ORF, "Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalI; putative membrane protein"
>YMR064W AEP1 SGDID:S000004668, Chr XIII from 397903-399459, Verified ORF, "Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase"
>YMR065W KAR5 SGDID:S000004669, Chr XIII from 399702-401216, Verified ORF, "Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone"
>YMR066W SOV1 SGDID:S000004670, Chr XIII from 401541-404237, Verified ORF, "Mitochondrial protein of unknown function"
>YMR067C UBX4 SGDID:S000004671, Chr XIII from 405573-404323, reverse complement, Verified ORF, "UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p"
>YMR068W AVO2 SGDID:S000004672, Chr XIII from 406304-407584, Verified ORF, "Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth"
>YMR069W NAT4 SGDID:S000004673, Chr XIII from 407709-408566, Verified ORF, "N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A"
>YMR070W MOT3 SGDID:S000004674, Chr XIII from 409154-410626, Verified ORF, "Nuclear transcription factor with two Cys2-His2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes"
>YMR071C TVP18 SGDID:S000004675, Chr XIII from 411265-410762, reverse complement, Verified ORF, "Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments"
>YMR072W ABF2 SGDID:S000004676, Chr XIII from 411569-412120, Verified ORF, "Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation"
>YMR073C IRC21 SGDID:S000004677, Chr XIII from 412873-412268, reverse complement, Verified ORF, "Putative protein of unknown function; proposed to be involved in resistance to carboplatin and cisplatin; shares similarity to a human cytochrome oxidoreductase; null mutant displays increased levels of spontaneous Rad52p foci"
>YMR074C YMR074C SGDID:S000004678, Chr XIII from 413473-413036, reverse complement, Verified ORF, "Protein with homology to human PDCD5, which is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene"
>YMR075C-A YMR075C-A SGDID:S000004679, Chr XIII from 416053-415688, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RCO1/YMR075W"
>YMR075W RCO1 SGDID:S000004680, Chr XIII from 413982-416036, Verified ORF, "Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p"
>YMR076C PDS5 SGDID:S000004681, Chr XIII from 420029-416196, reverse complement, Verified ORF, "Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes, may function as a protein-protein interaction scaffold; also required during meiosis"
>YMR077C VPS20 SGDID:S000004682, Chr XIII from 422149-421484, reverse complement, Verified ORF, "Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes"
>YMR078C CTF18 SGDID:S000004683, Chr XIII from 424728-422503, reverse complement, Verified ORF, "Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint"
>YMR079W SEC14 SGDID:S000004684, Chr XIII from 424989-424997,425154-426059, Verified ORF, "Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; functionally homologous to mammalian PITPs"
>YMR080C NAM7 SGDID:S000004685, Chr XIII from 429627-426712, reverse complement, Verified ORF, "ATP-dependent RNA helicase of the SFI superfamily involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance"
>YMR081C ISF1 SGDID:S000004686, Chr XIII from 431095-430079, reverse complement, Verified ORF, "Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant"
>YMR082C YMR082C SGDID:S000004687, Chr XIII from 432125-431769, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YMR083W ADH3 SGDID:S000004688, Chr XIII from 434788-435915, Verified ORF, "Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production"
>YMR084W YMR084W SGDID:S000004689, Chr XIII from 436628-437416, Uncharacterized ORF, "Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains"
>YMR085W YMR085W SGDID:S000004690, Chr XIII from 437491-438789, Uncharacterized ORF, "Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains"
>YMR086C-A YMR086C-A SGDID:S000004691, Chr XIII from 442364-442026, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YMR086W YMR086W SGDID:S000004692, Chr XIII from 439208-442090, Verified ORF, "Protein of unknown function that may interact with ribosomes, based on co-purification experiments; GFP-fusion protein localizes to the cell periphery; possible component of the eisosome; expression is repressed by cAMP"
>YMR087W YMR087W SGDID:S000004693, Chr XIII from 442527-443381, Verified ORF, "Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain"
>YMR088C VBA1 SGDID:S000004694, Chr XIII from 445102-443414, reverse complement, Verified ORF, "Permease of basic amino acids in the vacuolar membrane"
>YMR089C YTA12 SGDID:S000004695, Chr XIII from 448086-445609, reverse complement, Verified ORF, "Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes"
>YMR090W YMR090W SGDID:S000004696, Chr XIII from 449245-449928, Uncharacterized ORF, "Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability"
>YMR091C NPL6 SGDID:S000004697, Chr XIII from 451365-450058, reverse complement, Verified ORF, "Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range of RSC functions; involved in nuclear protein import and maintenance of proper telomere length"
>YMR092C AIP1 SGDID:S000004698, Chr XIII from 453479-451632, reverse complement, Verified ORF, "Actin cortical patch component, interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats"
>YMR093W UTP15 SGDID:S000004699, Chr XIII from 454015-455556, Verified ORF, "Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA"
>YMR094W CTF13 SGDID:S000004700, Chr XIII from 455825-457261, Verified ORF, "Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis"
>YMR095C SNO1 SGDID:S000004701, Chr XIII from 457959-457285, reverse complement, Verified ORF, "Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase"
>YMR096W SNZ1 SGDID:S000004702, Chr XIII from 458408-459301, Verified ORF, "Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins"
>YMR097C MTG1 SGDID:S000004703, Chr XIII from 460527-459424, reverse complement, Verified ORF, "Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals"
>YMR098C ATP25 SGDID:S000004704, Chr XIII from 462609-460771, reverse complement, Verified ORF, "Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene"
>YMR099C YMR099C SGDID:S000004705, Chr XIII from 464827-463934, reverse complement, Verified ORF, "Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS"
>YMR100W MUB1 SGDID:S000004706, Chr XIII from 466300-468162, Verified ORF, "MYND domain-containing protein required for ubiquitination and turnover of Rpn4p; interacts with Ubr2p (E3) and indirectly with Rad6p (E2); short-lived protein degraded in a Ubr2p/Rad6p dependent manner; similar to the A. nidulans samB gene"
>YMR101C SRT1 SGDID:S000004707, Chr XIII from 469476-468445, reverse complement, Verified ORF, "Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase"
>YMR102C YMR102C SGDID:S000004708, Chr XIII from 472352-469848, reverse complement, Uncharacterized ORF, "Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene"
>YMR103C YMR103C SGDID:S000004709, Chr XIII from 473264-472902, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YMR104C YPK2 SGDID:S000004710, Chr XIII from 475453-473420, reverse complement, Verified ORF, "Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK"
>YMR105C PGM2 SGDID:S000004711, Chr XIII from 477606-475897, reverse complement, Verified ORF, "Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase"
>YMR105W-A YMR105W-A SGDID:S000028692, Chr XIII from 478064-478258, Uncharacterized ORF, "Putative protein of unknown function"
>YMR106C YKU80 SGDID:S000004712, Chr XIII from 480190-478301, reverse complement, Verified ORF, "Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair"
>YMR107W SPG4 SGDID:S000004713, Chr XIII from 483014-483361, Verified ORF, "Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources"
>YMR108W ILV2 SGDID:S000004714, Chr XIII from 484084-486147, Verified ORF, "Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control"
>YMR109W MYO5 SGDID:S000004715, Chr XIII from 486587-490246, Verified ORF, "One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization"
>YMR110C HFD1 SGDID:S000004716, Chr XIII from 491992-490394, reverse complement, Verified ORF, "Putative fatty aldehyde dehydrogenase, located in the mitochondrial outer membrane and also in lipid particles; has similarity to human fatty aldehyde dehydrogenase (FALDH) which is implicated in Sjogren-Larsson syndrome"
>YMR111C YMR111C SGDID:S000004717, Chr XIII from 493792-492404, reverse complement, Uncharacterized ORF, "Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene"
>YMR112C MED11 SGDID:S000004718, Chr XIII from 494495-494100, reverse complement, Verified ORF, "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein"
>YMR113W FOL3 SGDID:S000004719, Chr XIII from 494999-496282, Verified ORF, "Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis"
>YMR114C YMR114C SGDID:S000004720, Chr XIII from 497449-496343, reverse complement, Verified ORF, "Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene"
>YMR115W MGR3 SGDID:S000004721, Chr XIII from 497704-499209, Verified ORF, "Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA"
>YMR116C ASC1 SGDID:S000004722, Chr XIII from 499878-499456,500688-500152, reverse complement, Verified ORF, "G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; represses Gcn4p in the absence of amino acid starvation"
>YMR117C SPC24 SGDID:S000004723, Chr XIII from 501891-501250, reverse complement, Verified ORF, "Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering"
>YMR118C YMR118C SGDID:S000004724, Chr XIII from 502734-502144, reverse complement, Uncharacterized ORF, "Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene"
>YMR119W ASI1 SGDID:S000004725, Chr XIII from 505333-507207, Verified ORF, "Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals"
>YMR119W-A YMR119W-A SGDID:S000004726, Chr XIII from 506996-507370, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YMR120C ADE17 SGDID:S000004727, Chr XIII from 509280-507502, reverse complement, Verified ORF, "Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade16p; ade16 ade17 mutants require adenine and histidine"
>YMR121C RPL15B SGDID:S000004728, Chr XIII from 510348-509734, reverse complement, Verified ORF, "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Ap and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA"
>YMR122C YMR122C SGDID:S000004729, Chr XIII from 511075-510701, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YMR122W-A YMR122W-A SGDID:S000007524, Chr XIII from 511315-511569, Uncharacterized ORF, "Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and endoplasmic reticulum"
>YMR123W PKR1 SGDID:S000004730, Chr XIII from 513593-513961, Verified ORF, "V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0)"
>YMR124W YMR124W SGDID:S000004731, Chr XIII from 514456-517287, Uncharacterized ORF, "Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization"
>YMR125W STO1 SGDID:S000004732, Chr XIII from 517539-517563,517886-520446, Verified ORF, "Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80"
>YMR126C DLT1 SGDID:S000004733, Chr XIII from 521789-520761, reverse complement, Uncharacterized ORF, "Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)"
>YMR127C SAS2 SGDID:S000004734, Chr XIII from 523345-522329, reverse complement, Verified ORF, "Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family"
>YMR128W ECM16 SGDID:S000004735, Chr XIII from 523696-527499, Verified ORF, "Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis"
>YMR129W POM152 SGDID:S000004736, Chr XIII from 527804-531817, Verified ORF, "Nuclear pore membrane glycoprotein; may be involved in duplication of nuclear pores and nuclear pore complexes during S-phase;"
>YMR130W YMR130W SGDID:S000004737, Chr XIII from 532119-533027, Uncharacterized ORF, "Putative protein of unknown function; YMR130W is not an essential gene"
>YMR131C RRB1 SGDID:S000004738, Chr XIII from 534698-533163, reverse complement, Verified ORF, "Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p"
>YMR132C JLP2 SGDID:S000004739, Chr XIII from 535570-534944, reverse complement, Uncharacterized ORF, "Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)"
>YMR133W REC114 SGDID:S000004740, Chr XIII from 536207-537448,537565-537609, Verified ORF, "Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division"
>YMR134W YMR134W SGDID:S000004741, Chr XIII from 537838-538551, Uncharacterized ORF, "Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes"
>YMR135C GID8 SGDID:S000004742, Chr XIII from 540056-538689, reverse complement, Verified ORF, "Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START"
>YMR135W-A YMR135W-A SGDID:S000004743, Chr XIII from 539911-540444, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YMR136W GAT2 SGDID:S000004744, Chr XIII from 541199-542881, Verified ORF, "Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine"
>YMR137C PSO2 SGDID:S000004745, Chr XIII from 544963-542978, reverse complement, Verified ORF, "Nuclease required for a post-incision step in the repair of DNA single and double-strand breaks that result from interstrand crosslinks produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation"
>YMR138W CIN4 SGDID:S000004746, Chr XIII from 545155-545730, Verified ORF, "GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog"
>YMR139W RIM11 SGDID:S000004747, Chr XIII from 546125-547237, Verified ORF, "Protein kinase required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta"
>YMR140W SIP5 SGDID:S000004748, Chr XIII from 547714-549183, Verified ORF, "Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase"
>YMR141C YMR141C SGDID:S000004749, Chr XIII from 550044-549736, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YMR141W-A YMR141W-A SGDID:S000028575, Chr XIII from 550911-551135, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene RPL13B/YMR142C"
>YMR142C RPL13B SGDID:S000004750, Chr XIII from 550801-550206,551207-551204, reverse complement, Verified ORF, "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Ap; not essential for viability; has similarity to rat L13 ribosomal protein"
>YMR143W RPS16A SGDID:S000004751, Chr XIII from 551928-551951,552496-552903, Verified ORF, "Protein component of the small (40S) ribosomal subunit; identical to Rps16Bp and has similarity to E. coli S9 and rat S16 ribosomal proteins"
>YMR144W YMR144W SGDID:S000004752, Chr XIII from 553362-554390, Uncharacterized ORF, "Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene"
>YMR145C NDE1 SGDID:S000004753, Chr XIII from 556475-554793, reverse complement, Verified ORF, "Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain"
>YMR146C TIF34 SGDID:S000004754, Chr XIII from 558524-557481, reverse complement, Verified ORF, "eIF3i subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates rate of ribosomal scanning during translation reinitiation"
>YMR147W YMR147W SGDID:S000004755, Chr XIII from 559199-559870, Uncharacterized ORF, "Putative protein of unknown function"
>YMR148W OSW5 SGDID:S000004756, Chr XIII from 560366-560812, Verified ORF, "Protein of unknown function that may play a role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion"
>YMR149W SWP1 SGDID:S000004757, Chr XIII from 560996-561856, Verified ORF, "Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum"
>YMR150C IMP1 SGDID:S000004758, Chr XIII from 562528-561956, reverse complement, Verified ORF, "Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p"
>YMR151W YIM2 SGDID:S000004759, Chr XIII from 562506-562943, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1"
>YMR152W YIM1 SGDID:S000004760, Chr XIII from 563096-564193, Verified ORF, "Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YMR153C-A YMR153C-A SGDID:S000004761, Chr XIII from 565909-565574, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NUP53"
>YMR153W NUP53 SGDID:S000004762, Chr XIII from 564435-565862, Verified ORF, "Subunit of the nuclear pore complex (NPC), interacts with karyopherin Kap121p or with Nup170p via overlapping regions of Nup53p, involved in activation of the spindle checkpoint mediated by the Mad1p-Mad2p complex"
>YMR154C RIM13 SGDID:S000004763, Chr XIII from 568182-565999, reverse complement, Verified ORF, "Calpain-like cysteine protease involved in proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans palB"
>YMR155W YMR155W SGDID:S000004764, Chr XIII from 568551-570194, Uncharacterized ORF, "Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen"
>YMR156C TPP1 SGDID:S000004765, Chr XIII from 571016-570300, reverse complement, Verified ORF, "DNA 3'-phosphatase that functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; has similarity to the l-2-haloacid dehalogenase superfamily"
>YMR157C AIM36 SGDID:S000004766, Chr XIII from 572044-571277, reverse complement, Verified ORF, "Protein of unknown function; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies"
>YMR158C-A YMR158C-A SGDID:S000007249, Chr XIII from 573331-573194, reverse complement, Uncharacterized ORF, "Putative protein of unknown function, may contain a lipid attachment site; YMR158C-A is not an essential gene"
>YMR158W MRPS8 SGDID:S000004767, Chr XIII from 572248-572715, Verified ORF, "Mitochondrial ribosomal protein of the small subunit"
>YMR158W-B YMR158W-B SGDID:S000004768, Chr XIII from 574471-574791, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C"
>YMR159C ATG16 SGDID:S000004769, Chr XIII from 574928-574476, reverse complement, Verified ORF, "Conserved protein that interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy"
>YMR160W YMR160W SGDID:S000004770, Chr XIII from 575066-577516, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; mutant has enhanced sensitivity to overexpression of mutant huntingtin; YMR160W is not an essential gene"
>YMR161W HLJ1 SGDID:S000004771, Chr XIII from 577718-578392, Verified ORF, "Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ"
>YMR162C DNF3 SGDID:S000004772, Chr XIII from 583921-578951, reverse complement, Verified ORF, "Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase"
>YMR163C INP2 SGDID:S000004773, Chr XIII from 586388-584271, reverse complement, Verified ORF, "Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene"
>YMR164C MSS11 SGDID:S000004774, Chr XIII from 589550-587274, reverse complement, Verified ORF, "Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of MUC1 and STA2 in response to nutritional signals"
>YMR165C PAH1 SGDID:S000004775, Chr XIII from 592628-590040, reverse complement, Verified ORF, "Mg<sup>2+</sup>-dependent phosphatidate (PA) phosphatase, catalyzes the dephosphorylation of PA to yield diacylglycerol and P<sub>i</sub>, responsible for de novo lipid synthesis; homologous to mammalian lipin 1"
>YMR166C YMR166C SGDID:S000004776, Chr XIII from 594473-593367, reverse complement, Uncharacterized ORF, "Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene"
>YMR167W MLH1 SGDID:S000004777, Chr XIII from 594886-597195, Verified ORF, "Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer"
>YMR168C CEP3 SGDID:S000004778, Chr XIII from 599158-597332, reverse complement, Verified ORF, "Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain"
>YMR169C ALD3 SGDID:S000004779, Chr XIII from 600872-599352, reverse complement, Verified ORF, "Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose"
>YMR170C ALD2 SGDID:S000004780, Chr XIII from 603082-601562, reverse complement, Verified ORF, "Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p"
>YMR171C EAR1 SGDID:S000004781, Chr XIII from 605520-603868, reverse complement, Verified ORF, "Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p"
>YMR172C-A YMR172C-A SGDID:S000004782, Chr XIII from 608211-607828, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YMR172W HOT1 SGDID:S000004783, Chr XIII from 605981-608140, Verified ORF, "Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p"
>YMR173W DDR48 SGDID:S000004784, Chr XIII from 608689-609981, Verified ORF, "DNA damage-responsive protein, expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS"
>YMR173W-A YMR173W-A SGDID:S000004785, Chr XIII from 608897-610081, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene DDR48/YML173W"
>YMR174C PAI3 SGDID:S000004786, Chr XIII from 610365-610159, reverse complement, Verified ORF, "Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact"
>YMR175W SIP18 SGDID:S000004787, Chr XIII from 611016-611255, Verified ORF, "Phospholipid-binding protein; expression is induced by osmotic stress"
>YMR175W-A YMR175W-A SGDID:S000028848, Chr XIII from 611314-611508, Uncharacterized ORF, "Putative protein of unknown function"
>YMR176W ECM5 SGDID:S000004788, Chr XIII from 611740-615975, Verified ORF, "Non-essential protein of unknown function, contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks"
>YMR177W MMT1 SGDID:S000004789, Chr XIII from 616566-618098, Verified ORF, "Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p"
>YMR178W YMR178W SGDID:S000004790, Chr XIII from 618479-619303, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR178W is not an essential gene"
>YMR179W SPT21 SGDID:S000004791, Chr XIII from 619858-622134, Verified ORF, "Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p"
>YMR180C CTL1 SGDID:S000004792, Chr XIII from 623213-622251, reverse complement, Verified ORF, "RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm"
>YMR181C YMR181C SGDID:S000004793, Chr XIII from 624080-623616, reverse complement, Uncharacterized ORF, "Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); YMR181C is not an essential gene"
>YMR182C RGM1 SGDID:S000004794, Chr XIII from 625167-624532, reverse complement, Verified ORF, "Putative transcriptional repressor with proline-rich zinc fingers; overproduction impairs cell growth"
>YMR182W-A YMR182W-A SGDID:S000028693, Chr XIII from 625811-625897, Uncharacterized ORF, "Putative protein of unknown function"
>YMR183C SSO2 SGDID:S000004795, Chr XIII from 627808-626921, reverse complement, Verified ORF, "Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p"
>YMR184W ADD37 SGDID:S000004796, Chr XIII from 628189-628785, Verified ORF, "Protein of unknown function involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene"
>YMR185W YMR185W SGDID:S000004797, Chr XIII from 629025-631970, Uncharacterized ORF, "Putative protein of unknown function; conflicting evidence on whether null mutant is viable with elongated buds, or inviable"
>YMR186W HSC82 SGDID:S000004798, Chr XIII from 632355-634472, Verified ORF, "Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock"
>YMR187C YMR187C SGDID:S000004799, Chr XIII from 635984-634689, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; YMR187C is not an essential gene"
>YMR188C MRPS17 SGDID:S000004800, Chr XIII from 637004-636291, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the small subunit"
>YMR189W GCV2 SGDID:S000004801, Chr XIII from 637500-640604, Verified ORF, "P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm"
>YMR190C SGS1 SGDID:S000004802, Chr XIII from 645258-640915, reverse complement, Verified ORF, "Nucleolar DNA helicase of the RecQ family involved in genome integrity maintenance; regulates chromosome synapsis and meiotic joint molecule/crossover formation; similar to human BLM and WRN proteins implicated in Bloom and Werner syndromes"
>YMR191W SPG5 SGDID:S000004803, Chr XIII from 645656-646777, Verified ORF, "Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources"
>YMR192W GYL1 SGDID:S000004804, Chr XIII from 647118-649280, Verified ORF, "Putative GTPase activating protein (GAP) that may have a role in polarized exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p"
>YMR193C-A YMR193C-A SGDID:S000004805, Chr XIII from 651458-651072, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YMR193W MRPL24 SGDID:S000004806, Chr XIII from 650036-650812, Verified ORF, "Mitochondrial ribosomal protein of the large subunit"
>YMR194C-A YMR194C-A SGDID:S000007250, Chr XIII from 653136-652912, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YMR194C-B CMC4 SGDID:S000028514, Chr XIII from 652775-652594,652887-652848, reverse complement, Verified ORF, "Protein that localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; contains twin cysteine-x(9)-cysteine motifs"
>YMR194W RPL36A SGDID:S000004807, Chr XIII from 651145-651160,651624-651910, Verified ORF, "N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Bp and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA"
>YMR195W ICY1 SGDID:S000004808, Chr XIII from 654034-654417, Verified ORF, "Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation"
>YMR196W YMR196W SGDID:S000004809, Chr XIII from 655076-658342, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene"
>YMR197C VTI1 SGDID:S000004810, Chr XIII from 659198-658545, reverse complement, Verified ORF, "Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways"
>YMR198W CIK1 SGDID:S000004811, Chr XIII from 659745-661529, Verified ORF, "Kinesin-associated protein required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role; has similarity to Vik1p"
>YMR199W CLN1 SGDID:S000004812, Chr XIII from 662644-664284, Verified ORF, "G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)"
>YMR200W ROT1 SGDID:S000004813, Chr XIII from 664752-665522, Verified ORF, "Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations"
>YMR201C RAD14 SGDID:S000004814, Chr XIII from 666933-665845,667044-667018, reverse complement, Verified ORF, "Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein"
>YMR202W ERG2 SGDID:S000004815, Chr XIII from 667537-668205, Verified ORF, "C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis"
>YMR203W TOM40 SGDID:S000004816, Chr XIII from 668492-669655, Verified ORF, "Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore"
>YMR204C INP1 SGDID:S000004817, Chr XIII from 671325-670063, reverse complement, Verified ORF, "Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane"
>YMR205C PFK2 SGDID:S000004818, Chr XIII from 674766-671887, reverse complement, Verified ORF, "Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes"
>YMR206W YMR206W SGDID:S000004819, Chr XIII from 675896-676837, Uncharacterized ORF, "Putative protein of unknown function; YMR206W is not an essential gene"
>YMR207C HFA1 SGDID:S000004820, Chr XIII from 683564-677193, reverse complement, Verified ORF, "Mitochondrial acetyl-coenzyme A carboxylase, catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis"
>YMR208W ERG12 SGDID:S000004821, Chr XIII from 684467-685798, Verified ORF, "Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate"
>YMR209C YMR209C SGDID:S000004822, Chr XIII from 687284-685911, reverse complement, Uncharacterized ORF, "Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene"
>YMR210W YMR210W SGDID:S000004823, Chr XIII from 687516-688865, Verified ORF, "Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification"
>YMR211W DML1 SGDID:S000004824, Chr XIII from 689083-690510, Verified ORF, "Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family"
>YMR212C EFR3 SGDID:S000004825, Chr XIII from 693043-690695, reverse complement, Verified ORF, "Protein required for Stt4-containing phosphoinositide kinase patch assembly at the plasma membrane; exhibits synthetic lethal genetic interactions with PHO85; has sequence similarity to the Drosophila rolling blackout (RBO) gene"
>YMR213W CEF1 SGDID:S000004826, Chr XIII from 693381-695153, Verified ORF, "Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p"
>YMR214W SCJ1 SGDID:S000004827, Chr XIII from 695350-696483, Verified ORF, "One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins"
>YMR215W GAS3 SGDID:S000004828, Chr XIII from 696796-698370, Verified ORF, "Putative 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall"
>YMR216C SKY1 SGDID:S000004829, Chr XIII from 701039-698811, reverse complement, Verified ORF, "SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1"
>YMR217W GUA1 SGDID:S000004830, Chr XIII from 701790-703367, Verified ORF, "GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation"
>YMR218C TRS130 SGDID:S000004831, Chr XIII from 706887-703579, reverse complement, Verified ORF, "One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1"
>YMR219W ESC1 SGDID:S000004832, Chr XIII from 707133-712109, Verified ORF, "Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p"
>YMR220W ERG8 SGDID:S000004833, Chr XIII from 712316-713671, Verified ORF, "Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate"
>YMR221C YMR221C SGDID:S000004834, Chr XIII from 715445-713931, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy"
>YMR222C FSH2 SGDID:S000004835, Chr XIII from 716309-715638, reverse complement, Verified ORF, "Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2"
>YMR223W UBP8 SGDID:S000004836, Chr XIII from 716715-718130, Verified ORF, "Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B"
>YMR224C MRE11 SGDID:S000004837, Chr XIII from 720653-718575, reverse complement, Verified ORF, "Subunit of a complex with Rad50p and Xrs2p (MRX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for MRX function; widely conserved"
>YMR225C MRPL44 SGDID:S000004838, Chr XIII from 721198-720960,721403-721346, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the large subunit"
>YMR226C YMR226C SGDID:S000004839, Chr XIII from 722396-721593, reverse complement, Verified ORF, "NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments"
>YMR227C TAF7 SGDID:S000004840, Chr XIII from 724385-722613, reverse complement, Verified ORF, "TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation"
>YMR228W MTF1 SGDID:S000004841, Chr XIII from 724626-725651, Verified ORF, "Mitochondrial RNA polymerase specificity factor with structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors, interacts with mitochondrial core polymerase Rpo41p"
>YMR229C RRP5 SGDID:S000004842, Chr XIII from 731123-725934, reverse complement, Verified ORF, "RNA binding protein with preference for single stranded tracts of U's involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome"
>YMR230W RPS10B SGDID:S000004843, Chr XIII from 732414-732465,732876-733141, Verified ORF, "Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Ap and has similarity to rat ribosomal protein S10"
>YMR230W-A YMR230W-A SGDID:S000028576, Chr XIII from 733268-733456, Uncharacterized ORF, "Putative protein of unknown function"
>YMR231W PEP5 SGDID:S000004844, Chr XIII from 733545-736634, Verified ORF, "Component of CORVET tethering complex; peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; interacts with Pep7p"
>YMR232W FUS2 SGDID:S000004845, Chr XIII from 736926-738959, Verified ORF, "Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating"
>YMR233W TRI1 SGDID:S000004846, Chr XIII from 739185-739865, Verified ORF, "Non-essential sumoylated protein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus"
>YMR234W RNH1 SGDID:S000004847, Chr XIII from 740266-741312, Verified ORF, "Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201)"
>YMR235C RNA1 SGDID:S000004848, Chr XIII from 742735-741512, reverse complement, Verified ORF, "GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport"
>YMR236W TAF9 SGDID:S000004849, Chr XIII from 742971-743444, Verified ORF, "Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3"
>YMR237W BCH1 SGDID:S000004850, Chr XIII from 743749-745923, Verified ORF, "Member of the ChAPs family (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes"
>YMR238W DFG5 SGDID:S000004851, Chr XIII from 746353-747729, Verified ORF, "Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p"
>YMR239C RNT1 SGDID:S000004852, Chr XIII from 749677-748262, reverse complement, Verified ORF, "RNAase III; involved in rDNA transcription and rRNA processing; also cleaves a stem-loop structure at the 3' end of U2 snRNA to ensure formation of the correct U2 3' end; involved in polyadenylation-independent transcription termination"
>YMR240C CUS1 SGDID:S000004853, Chr XIII from 751240-749930, reverse complement, Verified ORF, "Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p"
>YMR241W YHM2 SGDID:S000004854, Chr XIII from 751961-752905, Verified ORF, "Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome"
>YMR242C RPL20A SGDID:S000004855, Chr XIII from 753742-753225,754220-754220, reverse complement, Verified ORF, "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Bp and has similarity to rat L18a ribosomal protein"
>YMR242W-A YMR242W-A SGDID:S000028694, Chr XIII from 754297-754386, Uncharacterized ORF, "Putative protein of unknown function"
>YMR243C ZRC1 SGDID:S000004856, Chr XIII from 756166-754838, reverse complement, Verified ORF, "Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm"
>YMR244C-A YMR244C-A SGDID:S000004857, Chr XIII from 758831-758517, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR244C-A is not an essential gene"
>YMR244W YMR244W SGDID:S000004858, Chr XIII from 757250-758317, Uncharacterized ORF, "Putative protein of unknown function"
>YMR245W YMR245W SGDID:S000004859, Chr XIII from 758563-759183, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YMR246W FAA4 SGDID:S000004860, Chr XIII from 759807-761891, Verified ORF, "Long chain fatty acyl-CoA synthetase, activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles"
>YMR247C RKR1 SGDID:S000004861, Chr XIII from 768039-763351, reverse complement, Verified ORF, "RING domain E3 ubiquitin ligase; involved in the ubiquitin-mediated degradation of non-stop proteins; functional connections to chromatin modification; nuclear protein that also co-localizes with ribosomes; homolog of mouse listerin"
>YMR247W-A YMR247W-A SGDID:S000028849, Chr XIII from 769283-769426, Uncharacterized ORF, "Putative protein of unknown function"
>YMR250W GAD1 SGDID:S000004862, Chr XIII from 770801-772558, Verified ORF, "Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress"
>YMR251W GTO3 SGDID:S000004863, Chr XIII from 772915-774015, Verified ORF, "Omega class glutathione transferase; putative cytosolic localization"
>YMR251W-A HOR7 SGDID:S000004864, Chr XIII from 774752-774931, Verified ORF, "Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor"
>YMR252C YMR252C SGDID:S000004865, Chr XIII from 775719-775315, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene"
>YMR253C YMR253C SGDID:S000004866, Chr XIII from 777190-775946, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene"
>YMR254C YMR254C SGDID:S000004867, Chr XIII from 777923-777615, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YMR255W GFD1 SGDID:S000004868, Chr XIII from 778001-778567, Verified ORF, "Coiled-coiled protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation"
>YMR256C COX7 SGDID:S000004869, Chr XIII from 779127-778945, reverse complement, Verified ORF, "Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain"
>YMR257C PET111 SGDID:S000004870, Chr XIII from 782031-779629, reverse complement, Verified ORF, "Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane"
>YMR258C YMR258C SGDID:S000004871, Chr XIII from 784281-782620, reverse complement, Uncharacterized ORF, "Protein of unknown function with similarity to F-box proteins; physically interacts with Skp1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR258C is not an essential gene"
>YMR259C YMR259C SGDID:S000004872, Chr XIII from 788883-784621, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR259C is not an essential gene"
>YMR260C TIF11 SGDID:S000004873, Chr XIII from 789839-789378, reverse complement, Verified ORF, "Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3"
>YMR261C TPS3 SGDID:S000004874, Chr XIII from 793369-790205, reverse complement, Verified ORF, "Regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway"
>YMR262W YMR262W SGDID:S000004875, Chr XIII from 793726-794667, Uncharacterized ORF, "Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene"
>YMR263W SAP30 SGDID:S000004876, Chr XIII from 794919-795524, Verified ORF, "Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance"
>YMR264W CUE1 SGDID:S000004877, Chr XIII from 795805-796416, Verified ORF, "Endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination"
>YMR265C YMR265C SGDID:S000004878, Chr XIII from 797925-796540, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YMR266W RSN1 SGDID:S000004879, Chr XIII from 798518-801379, Verified ORF, "Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant cells by restoring sodium pump (Ena1p) localization to the plasma membrane"
>YMR267W PPA2 SGDID:S000004880, Chr XIII from 801772-802704, Verified ORF, "Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate"
>YMR268C PRP24 SGDID:S000004881, Chr XIII from 804222-802888, reverse complement, Verified ORF, "Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling"
>YMR269W TMA23 SGDID:S000004882, Chr XIII from 804456-805091, Verified ORF, "Nucleolar protein of unknown function implicated in ribosome biogenesis; TMA23 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes"
>YMR270C RRN9 SGDID:S000004883, Chr XIII from 806423-805326, reverse complement, Verified ORF, "Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I"
>YMR271C URA10 SGDID:S000004884, Chr XIII from 807548-806865, reverse complement, Verified ORF, "Minor orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; major OPRTase encoded by URA5"
>YMR272C SCS7 SGDID:S000004885, Chr XIII from 810777-809623, reverse complement, Verified ORF, "Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth"
>YMR272W-A YMR272W-A SGDID:S000028695, Chr XIII from 810466-810579, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SCS7/YMR272C"
>YMR272W-B YMR272W-B SGDID:S000028696, Chr XIII from 811089-811196, Uncharacterized ORF, "Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YMR273C ZDS1 SGDID:S000004886, Chr XIII from 813980-811233, reverse complement, Verified ORF, "Protein with a role in regulating Swe1p-dependent polarized growth; interacts with silencing proteins at the telomere; has a role in Bcy1p localization; implicated in mRNA nuclear export; involved in mitotic exit through Cdc14p regulation"
>YMR274C RCE1 SGDID:S000004887, Chr XIII from 815311-814364, reverse complement, Verified ORF, "Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone"
>YMR275C BUL1 SGDID:S000004888, Chr XIII from 818581-815651, reverse complement, Verified ORF, "Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex, functional homolog of Bul2p, disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases"
>YMR276W DSK2 SGDID:S000004889, Chr XIII from 818827-819948, Verified ORF, "Nuclear-enriched ubiquitin-like polyubiquitin-binding protein, required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle, involved in proteolysis, interacts with the proteasome"
>YMR277W FCP1 SGDID:S000004890, Chr XIII from 820256-822454, Verified ORF, "Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p)"
>YMR278W PGM3 SGDID:S000004891, Chr XIII from 822763-824631, Verified ORF, "Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential"
>YMR279C YMR279C SGDID:S000004892, Chr XIII from 826351-824729, reverse complement, Uncharacterized ORF, "Putative paralog of ATR1, but not required for boron tolerance; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene"
>YMR280C CAT8 SGDID:S000004893, Chr XIII from 831329-827028, reverse complement, Verified ORF, "Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements"
>YMR281W GPI12 SGDID:S000004894, Chr XIII from 832339-833253, Verified ORF, "ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp"
>YMR282C AEP2 SGDID:S000004895, Chr XIII from 835098-833356, reverse complement, Verified ORF, "Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader"
>YMR283C RIT1 SGDID:S000004896, Chr XIII from 836867-835326, reverse complement, Verified ORF, "2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA"
>YMR284W YKU70 SGDID:S000004897, Chr XIII from 838187-839995, Verified ORF, "Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair"
>YMR285C NGL2 SGDID:S000004898, Chr XIII from 841691-840144, reverse complement, Verified ORF, "Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p and Ngl3p"
>YMR286W MRPL33 SGDID:S000004899, Chr XIII from 841942-842202, Verified ORF, "Mitochondrial ribosomal protein of the large subunit"
>YMR287C DSS1 SGDID:S000004900, Chr XIII from 845345-842436, reverse complement, Verified ORF, "3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs"
>YMR288W HSH155 SGDID:S000004901, Chr XIII from 845571-848486, Verified ORF, "U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155"
>YMR289W ABZ2 SGDID:S000004902, Chr XIII from 848685-849809, Verified ORF, "Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis"
>YMR290C HAS1 SGDID:S000004903, Chr XIII from 851591-850074, reverse complement, Verified ORF, "ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles"
>YMR290W-A YMR290W-A SGDID:S000004904, Chr XIII from 851422-851769, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase"
>YMR291W YMR291W SGDID:S000004905, Chr XIII from 852630-854390, Uncharacterized ORF, "Putative kinase of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR291W is not an essential gene"
>YMR292W GOT1 SGDID:S000004906, Chr XIII from 854795-854816,854899-855293, Verified ORF, "Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition"
>YMR293C HER2 SGDID:S000004907, Chr XIII from 856793-855399, reverse complement, Verified ORF, "Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase"
>YMR294W JNM1 SGDID:S000004908, Chr XIII from 856966-858087, Verified ORF, "Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B"
>YMR294W-A YMR294W-A SGDID:S000004909, Chr XIII from 858209-858568, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, substantially overlaps YMR295C; deletion causes sensitivity to unfolded protein response-inducing agents"
>YMR295C YMR295C SGDID:S000004910, Chr XIII from 858890-858297, reverse complement, Verified ORF, "Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; YMR295C is not an essential gene"
>YMR296C LCB1 SGDID:S000004911, Chr XIII from 860891-859215, reverse complement, Verified ORF, "Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine"
>YMR297W PRC1 SGDID:S000004912, Chr XIII from 861922-863520, Verified ORF, "Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family"
>YMR298W LIP1 SGDID:S000004913, Chr XIII from 863819-864271, Verified ORF, "Ceramide synthase subunit; single-span ER membrane protein associated with Lag1p and Lac1p and required for ceramide synthase activity, null mutant grows extremely slowly and is defective in ceramide synthesis"
>YMR299C DYN3 SGDID:S000004914, Chr XIII from 865350-864412, reverse complement, Verified ORF, "Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration"
>YMR300C ADE4 SGDID:S000004915, Chr XIII from 867091-865559, reverse complement, Verified ORF, "Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway"
>YMR301C ATM1 SGDID:S000004916, Chr XIII from 869627-867555, reverse complement, Verified ORF, "Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol"
>YMR302C YME2 SGDID:S000004917, Chr XIII from 872625-870073, reverse complement, Verified ORF, "Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases"
>YMR303C ADH2 SGDID:S000004918, Chr XIII from 874337-873291, reverse complement, Verified ORF, "Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1"
>YMR304C-A YMR304C-A SGDID:S000004919, Chr XIII from 879130-878780, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SCW10"
>YMR304W UBP15 SGDID:S000004920, Chr XIII from 874987-878679, Verified ORF, "Ubiquitin-specific protease that may play a role in ubiquitin precursor processing"
>YMR305C SCW10 SGDID:S000004921, Chr XIII from 880232-879063, reverse complement, Verified ORF, "Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p"
>YMR306C-A YMR306C-A SGDID:S000004922, Chr XIII from 886572-886183, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YMR306W FKS3 SGDID:S000004923, Chr XIII from 881159-886516, Verified ORF, "Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YMR307C-A YMR307C-A SGDID:S000028578, Chr XIII from 887925-887731, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene GAS1/YMR307W"
>YMR307W GAS1 SGDID:S000004924, Chr XIII from 887003-888682, Verified ORF, "Beta-1,3-glucanosyltransferase, required for cell wall assembly and also has a role in transcriptional silencing; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at the nuclear periphery"
>YMR308C PSE1 SGDID:S000004925, Chr XIII from 892221-888952, reverse complement, Verified ORF, "Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p"
>YMR309C NIP1 SGDID:S000004926, Chr XIII from 895426-892988, reverse complement, Verified ORF, "eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection"
>YMR310C YMR310C SGDID:S000004927, Chr XIII from 896669-895716, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene"
>YMR311C GLC8 SGDID:S000004928, Chr XIII from 897603-896914, reverse complement, Verified ORF, "Regulatory subunit of protein phosphatase 1 (Glc7p), involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2"
>YMR312W ELP6 SGDID:S000004929, Chr XIII from 898405-899226, Verified ORF, "Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity"
>YMR313C TGL3 SGDID:S000004930, Chr XIII from 901307-899379, reverse complement, Verified ORF, "Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase activity; responsible for all the triacylglycerol lipase activity of the lipid particle; required with Tgl4p for timely bud formation"
>YMR314W PRE5 SGDID:S000004931, Chr XIII from 901709-902413, Verified ORF, "Alpha 6 subunit of the 20S proteasome"
>YMR315W YMR315W SGDID:S000004932, Chr XIII from 902800-903849, Verified ORF, "Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site"
>YMR315W-A YMR315W-A SGDID:S000028697, Chr XIII from 904286-904393, Uncharacterized ORF, "Putative protein of unknown function"
>YMR316C-A YMR316C-A SGDID:S000004933, Chr XIII from 905973-905662, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene DIA1/YMR316W"
>YMR316C-B YMR316C-B SGDID:S000004934, Chr XIII from 907629-907321, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YMR316W DIA1 SGDID:S000004935, Chr XIII from 904825-905835, Verified ORF, "Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern"
>YMR317W YMR317W SGDID:S000004936, Chr XIII from 907364-910786, Uncharacterized ORF, "Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene"
>YMR318C ADH6 SGDID:S000004937, Chr XIII from 912143-911061, reverse complement, Verified ORF, "NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance"
>YMR319C FET4 SGDID:S000004938, Chr XIII from 914538-912880, reverse complement, Verified ORF, "Low-affinity Fe(II) transporter of the plasma membrane"
>YMR320W YMR320W SGDID:S000004939, Chr XIII from 916746-917051, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YMR321C YMR321C SGDID:S000004940, Chr XIII from 917896-917579, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; proposed to be a palmitoylated membrane protein"
>YMR322C SNO4 SGDID:S000004941, Chr XIII from 919079-918366, reverse complement, Uncharacterized ORF, "Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation"
>YMR323W ERR3 SGDID:S000004942, Chr XIII from 920088-921401, Verified ORF, "Protein of unknown function, has similarity to enolases"
>YMR324C YMR324C SGDID:S000004943, Chr XIII from 922444-922202, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; transcription is AZF1 dependent in glycerol-lactate medium and SLT2 dependent in response to the lipid hydroperoxides"
>YMR325W PAU19 SGDID:S000004944, Chr XIII from 922641-923015, Verified ORF, "Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions"
>YMR326C YMR326C SGDID:S000004945, Chr XIII from 923802-923494, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13"
>YNL001W DOM34 SGDID:S000004946, Chr XIV from 627456-628616, Verified ORF, "Protein that, with binding partner Hbs1p, facilitates ribosomal subunit dissociation when translation is stalled; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog"
>YNL002C RLP7 SGDID:S000004947, Chr XIV from 627142-626174, reverse complement, Verified ORF, "Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs"
>YNL003C PET8 SGDID:S000004948, Chr XIV from 625829-624975, reverse complement, Verified ORF, "S-adenosylmethionine transporter of the mitochondrial inner membrane, member of the mitochondrial carrier family; required for biotin biosynthesis and respiratory growth"
>YNL004W HRB1 SGDID:S000004949, Chr XIV from 622915-622944,623287-624621, Verified ORF, "Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Gbp2p and Npl3p"
>YNL005C MRP7 SGDID:S000004950, Chr XIV from 622428-621313, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the large subunit"
>YNL006W LST8 SGDID:S000004951, Chr XIV from 620067-620978, Verified ORF, "Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat"
>YNL007C SIS1 SGDID:S000004952, Chr XIV from 619565-618507, reverse complement, Verified ORF, "Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; not functionally redundant with Ydj1p due to due to substrate specificity; shares similarity with bacterial DnaJ proteins"
>YNL008C ASI3 SGDID:S000004953, Chr XIV from 618241-616211, reverse complement, Verified ORF, "Putative integral membrane E3 ubiquitin ligase; acts with Asi1p and Asi2p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals"
>YNL009W IDP3 SGDID:S000004954, Chr XIV from 614821-616083, Verified ORF, "Peroxisomal NADP-dependent isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids"
>YNL010W YNL010W SGDID:S000004955, Chr XIV from 613635-614360, Uncharacterized ORF, "Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation"
>YNL011C YNL011C SGDID:S000004956, Chr XIV from 613170-611836, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; YNL011C is not an essential gene"
>YNL012W SPO1 SGDID:S000004957, Chr XIV from 609686-609790,609875-611665, Verified ORF, "Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B"
>YNL013C YNL013C SGDID:S000004958, Chr XIV from 609510-609133, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W"
>YNL014W HEF3 SGDID:S000004959, Chr XIV from 606319-609453, Verified ORF, "Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells"
>YNL015W PBI2 SGDID:S000004960, Chr XIV from 605384-605611, Verified ORF, "Cytosolic inhibitor of vacuolar proteinase B (PRB1), required for efficient vacuole inheritance; with thioredoxin forms protein complex LMA1, which assists in priming SNARE molecules and promotes vacuole fusion"
>YNL016W PUB1 SGDID:S000004961, Chr XIV from 602907-604268, Verified ORF, "Poly (A)+ RNA-binding protein, abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly"
>YNL017C YNL017C SGDID:S000004962, Chr XIV from 602476-602138, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the tRNA ORF tI(AAU)N2"
>YNL018C YNL018C SGDID:S000004963, Chr XIV from 601774-599936, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YNL019C YNL019C SGDID:S000004964, Chr XIV from 599230-598376, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YNL020C ARK1 SGDID:S000004965, Chr XIV from 597539-595623, reverse complement, Verified ORF, "Serine/threonine protein kinase involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis"
>YNL021W HDA1 SGDID:S000004966, Chr XIV from 593227-595347, Verified ORF, "Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation"
>YNL022C YNL022C SGDID:S000004967, Chr XIV from 592899-591427, reverse complement, Uncharacterized ORF, "Putative cytosine 5-methyltransferase, contains seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; predicted to be involved in ribosome biogenesis"
>YNL023C FAP1 SGDID:S000004968, Chr XIV from 591160-588263, reverse complement, Verified ORF, "Protein that binds to Fpr1p, conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1"
>YNL024C YNL024C SGDID:S000004969, Chr XIV from 587847-587107, reverse complement, Uncharacterized ORF, "Putative protein of unknown function with seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL024C is not an essential gene"
>YNL024C-A KSH1 SGDID:S000028698, Chr XIV from 586820-586602, reverse complement, Verified ORF, "Essential protein suggested to function early in the secretory pathway; inviability is suppressed by overexpression of Golgi protein Tvp23p; ortholog of human Kish"
>YNL025C SSN8 SGDID:S000004970, Chr XIV from 585291-584320, reverse complement, Verified ORF, "Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance"
>YNL026W SAM50 SGDID:S000004971, Chr XIV from 581920-583374, Verified ORF, "Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85"
>YNL027W CRZ1 SGDID:S000004972, Chr XIV from 579580-581616, Verified ORF, "Transcription factor that activates transcription of genes involved in stress response; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation"
>YNL028W YNL028W SGDID:S000004973, Chr XIV from 578679-578996, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YNL029C KTR5 SGDID:S000004974, Chr XIV from 578773-577205, reverse complement, Verified ORF, "Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family"
>YNL030W HHF2 SGDID:S000004975, Chr XIV from 576727-577038, Verified ORF, "Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF1); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity"
>YNL031C HHT2 SGDID:S000004976, Chr XIV from 576050-575640, reverse complement, Verified ORF, "Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation"
>YNL032W SIW14 SGDID:S000004977, Chr XIV from 574506-575351, Verified ORF, "Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm"
>YNL033W YNL033W SGDID:S000004978, Chr XIV from 572999-573853, Uncharacterized ORF, "Putative protein of unknown function"
>YNL034W YNL034W SGDID:S000004979, Chr XIV from 570477-572315, Uncharacterized ORF, "Putative protein of unknown function; YNL034W is not an essential gene"
>YNL035C YNL035C SGDID:S000004980, Chr XIV from 569691-568522, reverse complement, Uncharacterized ORF, "Putative protein of unknown function with similarity to proteins containing WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene"
>YNL036W NCE103 SGDID:S000004981, Chr XIV from 559814-560479, Verified ORF, "Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway"
>YNL037C IDH1 SGDID:S000004982, Chr XIV from 559002-557920, reverse complement, Verified ORF, "Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle"
>YNL038W GPI15 SGDID:S000004983, Chr XIV from 557020-557610,557685-557783, Verified ORF, "Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein"
>YNL039W BDP1 SGDID:S000004984, Chr XIV from 555048-556832, Verified ORF, "Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs"
>YNL040W YNL040W SGDID:S000004985, Chr XIV from 553380-554750, Uncharacterized ORF, "Putative protein of unknown function with strong similarity to alanyl-tRNA synthases from Eubacteria; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL040W is not an essential gene"
>YNL041C COG6 SGDID:S000004986, Chr XIV from 551987-549468, reverse complement, Verified ORF, "Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments"
>YNL042W BOP3 SGDID:S000004987, Chr XIV from 548100-549290, Verified ORF, "Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury"
>YNL042W-B YNL042W-B SGDID:S000028850, Chr XIV from 547113-547370, Uncharacterized ORF, "Putative protein of unknown function"
>YNL043C YNL043C SGDID:S000004988, Chr XIV from 545909-545589, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W"
>YNL044W YIP3 SGDID:S000004989, Chr XIV from 545268-545291,545371-545877, Verified ORF, "Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p"
>YNL045W LAP2 SGDID:S000004990, Chr XIV from 542963-544978, Verified ORF, "Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus"
>YNL046W YNL046W SGDID:S000004991, Chr XIV from 542304-542822, Uncharacterized ORF, "Putative protein of unknown function; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)"
>YNL047C SLM2 SGDID:S000004992, Chr XIV from 541881-539911, reverse complement, Verified ORF, "Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex"
>YNL048W ALG11 SGDID:S000004993, Chr XIV from 538173-539819, Verified ORF, "Alpha-1,2-mannosyltransferase, catalyzes sequential addition of the two terminal alpha 1,2-mannose residues to the Man5GlcNAc2-PP-dolichol intermediate during asparagine-linked glycosylation in the ER"
>YNL049C SFB2 SGDID:S000004994, Chr XIV from 537911-535281, reverse complement, Verified ORF, "Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb3p"
>YNL050C YNL050C SGDID:S000004995, Chr XIV from 534874-534079,534982-534966, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; YNL050c is not an essential gene"
>YNL051W COG5 SGDID:S000004996, Chr XIV from 532659-533870, Verified ORF, "Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments"
>YNL052W COX5A SGDID:S000004997, Chr XIV from 531725-532186, Verified ORF, "Subunit Va of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth"
>YNL053W MSG5 SGDID:S000004998, Chr XIV from 529942-531411, Verified ORF, "Dual-specificity protein phosphatase; exists in 2 isoforms; required for maintenance of a low level of signaling through the cell integrity pathway, adaptive response to pheromone; regulates and is regulated by Slt2p; dephosphorylates Fus3p"
>YNL054W VAC7 SGDID:S000004999, Chr XIV from 526086-529583, Verified ORF, "Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock"
>YNL054W-A YNL054W-A SGDID:S000007384, Chr XIV from 519456-520778, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YNL054W-B YNL054W-B SGDID:S000007385, Chr XIV from 519456-520760,520762-524706, pseudogene, "TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition"
>YNL055C POR1 SGDID:S000005000, Chr XIV from 518845-517994, reverse complement, Verified ORF, "Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated"
>YNL056W OCA2 SGDID:S000005001, Chr XIV from 517249-517842, Verified ORF, "Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene"
>YNL057W YNL057W SGDID:S000005002, Chr XIV from 516403-516735, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YNL058C YNL058C SGDID:S000005003, Chr XIV from 516713-515763, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene"
>YNL059C ARP5 SGDID:S000005004, Chr XIV from 514935-512668, reverse complement, Verified ORF, "Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes"
>YNL061W NOP2 SGDID:S000005005, Chr XIV from 510540-512396, Verified ORF, "Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles"
>YNL062C GCD10 SGDID:S000005006, Chr XIV from 510212-508776, reverse complement, Verified ORF, "Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression"
>YNL063W MTQ1 SGDID:S000005007, Chr XIV from 507758-508702, Verified ORF, "S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene"
>YNL064C YDJ1 SGDID:S000005008, Chr XIV from 507097-505868, reverse complement, Verified ORF, "Protein chaperone involved in regulation of the HSP90 and HSP70 functions; involved in protein translocation across membranes; member of the DnaJ family"
>YNL065W AQR1 SGDID:S000005009, Chr XIV from 503724-505484, Verified ORF, "Plasma membrane multidrug transporter of the major facilitator superfamily, confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids"
>YNL066W SUN4 SGDID:S000005010, Chr XIV from 501515-502777, Verified ORF, "Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family"
>YNL067W RPL9B SGDID:S000005011, Chr XIV from 499681-500256, Verified ORF, "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Ap and has similarity to E. coli L6 and rat L9 ribosomal proteins"
>YNL067W-A YNL067W-A SGDID:S000007623, Chr XIV from 498538-498684, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YNL067W-B YNL067W-B SGDID:S000028810, Chr XIV from 499417-499557, Uncharacterized ORF, "Putative protein of unknown function"
>YNL068C FKH2 SGDID:S000005012, Chr XIV from 498289-495701, reverse complement, Verified ORF, "Forkhead family transcription factor with a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase"
>YNL069C RPL16B SGDID:S000005013, Chr XIV from 494524-493956,495001-494974, reverse complement, Verified ORF, "N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Ap, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p"
>YNL070W TOM7 SGDID:S000005014, Chr XIV from 493366-493548, Verified ORF, "Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex"
>YNL071W LAT1 SGDID:S000005015, Chr XIV from 491523-492971, Verified ORF, "Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA"
>YNL072W RNH201 SGDID:S000005016, Chr XIV from 490317-491240, Verified ORF, "Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome"
>YNL073W MSK1 SGDID:S000005017, Chr XIV from 488386-490116, Verified ORF, "Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys)"
>YNL074C MLF3 SGDID:S000005018, Chr XIV from 488124-486766, reverse complement, Verified ORF, "Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide"
>YNL075W IMP4 SGDID:S000005019, Chr XIV from 485607-486479, Verified ORF, "Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs"
>YNL076W MKS1 SGDID:S000005020, Chr XIV from 483556-485310, Verified ORF, "Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling"
>YNL077W APJ1 SGDID:S000005021, Chr XIV from 481391-482977, Verified ORF, "Putative chaperone of the HSP40 (DNAJ) family; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YNL078W NIS1 SGDID:S000005022, Chr XIV from 479768-480991, Verified ORF, "Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network"
>YNL079C TPM1 SGDID:S000005023, Chr XIV from 479165-478566, reverse complement, Verified ORF, "Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently"
>YNL080C EOS1 SGDID:S000005024, Chr XIV from 478032-476932, reverse complement, Verified ORF, "Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene"
>YNL081C SWS2 SGDID:S000005025, Chr XIV from 476619-476188, reverse complement, Verified ORF, "Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency"
>YNL082W PMS1 SGDID:S000005026, Chr XIV from 473391-476012, Verified ORF, "ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL"
>YNL083W SAL1 SGDID:S000005027, Chr XIV from 471377-472861, Verified ORF, "ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains"
>YNL084C END3 SGDID:S000005028, Chr XIV from 471102-470053, reverse complement, Verified ORF, "EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p"
>YNL085W MKT1 SGDID:S000005029, Chr XIV from 467131-469623, Verified ORF, "Protein that forms a complex with Pbp1p that may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more"
>YNL086W SNN1 SGDID:S000005030, Chr XIV from 466334-466642, Uncharacterized ORF, "Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to endosomes"
>YNL087W TCB2 SGDID:S000005031, Chr XIV from 462411-465947, Verified ORF, "Bud-specific protein with a potential role in membrane trafficking; GFP-fusion protein migrates from the cell surface to intracellular vesicles near vacuole; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud"
>YNL088W TOP2 SGDID:S000005032, Chr XIV from 457704-461990, Verified ORF, "Topoisomerase II, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis"
>YNL089C YNL089C SGDID:S000005033, Chr XIV from 457169-456693, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins"
>YNL090W RHO2 SGDID:S000005034, Chr XIV from 456565-457143, Verified ORF, "Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly"
>YNL091W NST1 SGDID:S000005035, Chr XIV from 452408-456130, Verified ORF, "Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1"
>YNL092W YNL092W SGDID:S000005036, Chr XIV from 450871-452073, Uncharacterized ORF, "Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene"
>YNL093W YPT53 SGDID:S000005037, Chr XIV from 449868-450530, Verified ORF, "Rab family GTPase, similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis"
>YNL094W APP1 SGDID:S000005038, Chr XIV from 447611-449374, Verified ORF, "Protein of unknown function, interacts with Rvs161p and Rvs167p; computational analysis of protein-protein interactions in large-scale studies suggests a possible role in actin filament organization"
>YNL095C YNL095C SGDID:S000005039, Chr XIV from 446840-444912, reverse complement, Uncharacterized ORF, "Putative protein of unknown function predicted to contain a transmembrane domain; YNL095C is not an essential gene"
>YNL096C RPS7B SGDID:S000005040, Chr XIV from 443826-443398,444315-444172, reverse complement, Verified ORF, "Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Ap; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins"
>YNL097C PHO23 SGDID:S000005041, Chr XIV from 442358-441366, reverse complement, Verified ORF, "Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3"
>YNL097C-B YNL097C-B SGDID:S000028699, Chr XIV from 440919-440797, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YNL097W-A YNL097W-A SGDID:S000028700, Chr XIV from 441431-441586, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene PHO23/YNL097C"
>YNL098C RAS2 SGDID:S000005042, Chr XIV from 440570-439602, reverse complement, Verified ORF, "GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes"
>YNL099C OCA1 SGDID:S000005043, Chr XIV from 439283-438567, reverse complement, Verified ORF, "Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA"
>YNL100W AIM37 SGDID:S000005044, Chr XIV from 437613-438317, Verified ORF, "Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays reduced respiratory growth and reduced frequency of mitochondrial genome loss"
>YNL101W AVT4 SGDID:S000005045, Chr XIV from 434999-437140, Verified ORF, "Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters"
>YNL102W POL1 SGDID:S000005046, Chr XIV from 430087-434493, Verified ORF, "Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis"
>YNL103W MET4 SGDID:S000005047, Chr XIV from 427735-429753, Verified ORF, "Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p"
>YNL103W-A YNL103W-A SGDID:S000028701, Chr XIV from 426719-426808, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MET4/YNL104C"
>YNL104C LEU4 SGDID:S000005048, Chr XIV from 426754-424895, reverse complement, Verified ORF, "Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway"
>YNL105W RRT16 SGDID:S000005049, Chr XIV from 424155-424583, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription"
>YNL106C INP52 SGDID:S000005050, Chr XIV from 424495-420944, reverse complement, Verified ORF, "Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain"
>YNL107W YAF9 SGDID:S000005051, Chr XIV from 420098-420778, Verified ORF, "Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain"
>YNL108C YNL108C SGDID:S000005052, Chr XIV from 419826-419014, reverse complement, Uncharacterized ORF, "Putative protein of unknown function with similarity to Tfc7p and prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cytoplasm and nucleus"
>YNL109W YNL109W SGDID:S000005053, Chr XIV from 418964-419509, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YNL108C"
>YNL110C NOP15 SGDID:S000005054, Chr XIV from 418488-417826, reverse complement, Verified ORF, "Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm"
>YNL111C CYB5 SGDID:S000005055, Chr XIV from 417302-416940, reverse complement, Verified ORF, "Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation"
>YNL112W DBP2 SGDID:S000005056, Chr XIV from 413639-414911,415914-416281, Verified ORF, "Essential ATP-dependent RNA helicase of the DEAD-box protein family, involved in nonsense-mediated mRNA decay and rRNA processing"
>YNL113W RPC19 SGDID:S000005057, Chr XIV from 412771-413199, Verified ORF, "RNA polymerase subunit AC19, common to RNA polymerases I and III"
>YNL114C YNL114C SGDID:S000005058, Chr XIV from 413055-412684, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit"
>YNL115C YNL115C SGDID:S000005059, Chr XIV from 412053-410119, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene"
>YNL116W DMA2 SGDID:S000005060, Chr XIV from 408341-409909, Verified ORF, "Protein involved in ubiquitination; plays a role in regulating spindle position and orientation; functionally redundant with Dma1p; orthologous to human RNF8 protein, also has sequence similarity to human Chfr"
>YNL117W MLS1 SGDID:S000005061, Chr XIV from 406358-408022, Verified ORF, "Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium"
>YNL118C DCP2 SGDID:S000005062, Chr XIV from 405564-402652, reverse complement, Verified ORF, "Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; member of the Nudix hydrolase family"
>YNL119W NCS2 SGDID:S000005063, Chr XIV from 401040-402521, Verified ORF, "Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae"
>YNL120C YNL120C SGDID:S000005064, Chr XIV from 401518-401033, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene"
>YNL121C TOM70 SGDID:S000005065, Chr XIV from 400537-398684, reverse complement, Verified ORF, "Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins"
>YNL122C YNL122C SGDID:S000005066, Chr XIV from 398370-398023, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene"
>YNL123W NMA111 SGDID:S000005067, Chr XIV from 394685-397678, Verified ORF, "Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases"
>YNL124W NAF1 SGDID:S000005068, Chr XIV from 392892-394370, Verified ORF, "RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p"
>YNL125C ESBP6 SGDID:S000005069, Chr XIV from 392167-390146, reverse complement, Verified ORF, "Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane"
>YNL126W SPC98 SGDID:S000005070, Chr XIV from 387227-389767, Verified ORF, "Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque"
>YNL127W FAR11 SGDID:S000005071, Chr XIV from 383987-386848, Verified ORF, "Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2"
>YNL128W TEP1 SGDID:S000005072, Chr XIV from 382359-383663, Verified ORF, "Homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that has lipid phosphatase activity and is linked to the phosphatidylinositol signaling pathway; plays a role in normal sporulation"
>YNL129W NRK1 SGDID:S000005073, Chr XIV from 381480-382202, Verified ORF, "Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis"
>YNL130C CPT1 SGDID:S000005074, Chr XIV from 380689-379558,380831-380782, reverse complement, Verified ORF, "Cholinephosphotransferase, required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription"
>YNL130C-A DGR1 SGDID:S000028579, Chr XIV from 381391-381245, reverse complement, Uncharacterized ORF, "Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose"
>YNL131W TOM22 SGDID:S000005075, Chr XIV from 378767-379225, Verified ORF, "Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes"
>YNL132W KRE33 SGDID:S000005076, Chr XIV from 375321-378491, Verified ORF, "Essential protein, required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance"
>YNL133C FYV6 SGDID:S000005077, Chr XIV from 374692-374171, reverse complement, Verified ORF, "Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining"
>YNL134C YNL134C SGDID:S000005078, Chr XIV from 373581-372451, reverse complement, Uncharacterized ORF, "Putative protein of unknown function with similarity to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced by the DNA-damaging agent MMS"
>YNL135C FPR1 SGDID:S000005079, Chr XIV from 372226-371882, reverse complement, Verified ORF, "Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function"
>YNL136W EAF7 SGDID:S000005080, Chr XIV from 370368-371645, Verified ORF, "Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A"
>YNL137C NAM9 SGDID:S000005081, Chr XIV from 370055-368595, reverse complement, Verified ORF, "Mitochondrial ribosomal component of the small subunit"
>YNL138W SRV2 SGDID:S000005082, Chr XIV from 366741-368321, Verified ORF, "CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis"
>YNL138W-A YSF3 SGDID:S000028509, Chr XIV from 366033-366035,366158-366412, Verified ORF, "Component of the SF3b subcomplex of the U2 snRNP, essential protein required for for splicing and for assembly of SF3b"
>YNL139C THO2 SGDID:S000005083, Chr XIV from 365717-360924, reverse complement, Verified ORF, "Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids"
>YNL140C YNL140C SGDID:S000005084, Chr XIV from 361486-360917, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene THO2/YNL139C"
>YNL141W AAH1 SGDID:S000005085, Chr XIV from 359596-360639, Verified ORF, "Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome"
>YNL142W MEP2 SGDID:S000005086, Chr XIV from 357453-358952, Verified ORF, "Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation"
>YNL143C YNL143C SGDID:S000005087, Chr XIV from 357186-356794, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YNL144C YNL144C SGDID:S000005088, Chr XIV from 355042-352820, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene"
>YNL144W-A YNL144W-A SGDID:S000028702, Chr XIV from 353061-353144, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YNL144C"
>YNL145W MFA2 SGDID:S000005089, Chr XIV from 352414-352530, Verified ORF, "Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1"
>YNL146C-A YNL146C-A SGDID:S000028851, Chr XIV from 351580-351386, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YNL146W YNL146W SGDID:S000005090, Chr XIV from 351715-352017, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNL146W is not an essential gene"
>YNL147W LSM7 SGDID:S000005091, Chr XIV from 350940-350957,351054-351383, Verified ORF, "Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA"
>YNL148C ALF1 SGDID:S000005092, Chr XIV from 350671-349907, reverse complement, Verified ORF, "Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance"
>YNL149C PGA2 SGDID:S000005093, Chr XIV from 349756-349367, reverse complement, Verified ORF, "Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect"
>YNL150W YNL150W SGDID:S000005094, Chr XIV from 349251-349658, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; extensive overlap with PGA2/YNL149C, an uncharacterized gene with a proposed role in protein trafficking"
>YNL151C RPC31 SGDID:S000005095, Chr XIV from 348521-347766, reverse complement, Verified ORF, "RNA polymerase III subunit C31"
>YNL152W INN1 SGDID:S000005096, Chr XIV from 346313-347542, Verified ORF, "Essential protein that associates with the contractile actomyosin ring, required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function"
>YNL153C GIM3 SGDID:S000005097, Chr XIV from 346058-345669, reverse complement, Verified ORF, "Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it"
>YNL154C YCK2 SGDID:S000005098, Chr XIV from 345276-343636, reverse complement, Verified ORF, "Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck1p"
>YNL155W YNL155W SGDID:S000005099, Chr XIV from 342516-343340, Uncharacterized ORF, "Putative protein of unknown function, contains DHHC domain, also predicted to have thiol-disulfide oxidoreductase active site"
>YNL156C NSG2 SGDID:S000005100, Chr XIV from 341968-341069, reverse complement, Verified ORF, "Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins"
>YNL157W IGO1 SGDID:S000005101, Chr XIV from 340352-340858, Verified ORF, "Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo2p"
>YNL158W PGA1 SGDID:S000005102, Chr XIV from 339612-340208, Verified ORF, "Essential component of GPI-mannosyltransferase II, responsible for second mannose addition to GPI precursors as a partner of Gpi18p; required for maturation of Gas1p and Pho8p; has synthetic genetic interations with secretory pathway genes"
>YNL159C ASI2 SGDID:S000005103, Chr XIV from 339347-338478, reverse complement, Verified ORF, "Integral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals"
>YNL160W YGP1 SGDID:S000005104, Chr XIV from 336545-337609, Verified ORF, "Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p"
>YNL161W CBK1 SGDID:S000005105, Chr XIV from 332597-334867, Verified ORF, "Serine/threonine protein kinase that regulates cell morphogenesis pathways; involved in cell wall biosynthesis, apical growth, proper mating projection morphology, bipolar bud site selection in diploid cells, and cell separation"
>YNL162W RPL42A SGDID:S000005106, Chr XIV from 331322-331325,331838-332154, Verified ORF, "Protein component of the large (60S) ribosomal subunit, identical to Rpl42Bp and has similarity to rat L44 ribosomal protein"
>YNL162W-A YNL162W-A SGDID:S000007624, Chr XIV from 330329-330547, Uncharacterized ORF, "Putative protein of unknown function; identified by homology"
>YNL163C RIA1 SGDID:S000005107, Chr XIV from 330073-326741, reverse complement, Verified ORF, "Cytoplasmic GTPase involved in biogenesis of the 60S ribosome; has similarity to translation elongation factor 2 (Eft1p and Eft2p)"
>YNL164C IBD2 SGDID:S000005108, Chr XIV from 326320-325265, reverse complement, Verified ORF, "Component of the BUB2-dependent spindle checkpoint pathway, interacts with Bfa1p and functions upstream of Bub2p and Bfa1p"
>YNL165W YNL165W SGDID:S000005109, Chr XIV from 323832-325052, Uncharacterized ORF, "Putative protein of unknown function; YNL165W is not an essential gene"
>YNL166C BNI5 SGDID:S000005110, Chr XIV from 323565-322219, reverse complement, Verified ORF, "Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner"
>YNL167C SKO1 SGDID:S000005111, Chr XIV from 321359-319416, reverse complement, Verified ORF, "Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, forms a complex with Tup1p and Ssn6p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses"
>YNL168C FMP41 SGDID:S000005112, Chr XIV from 318809-318030, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YNL169C PSD1 SGDID:S000005113, Chr XIV from 317671-316169, reverse complement, Verified ORF, "Phosphatidylserine decarboxylase of the mitochondrial inner membrane, converts phosphatidylserine to phosphatidylethanolamine"
>YNL170W YNL170W SGDID:S000005114, Chr XIV from 315978-316373, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YNL171C YNL171C SGDID:S000005115, Chr XIV from 315997-315629, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YNL172W APC1 SGDID:S000005116, Chr XIV from 310636-315882, Verified ORF, "Largest subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition"
>YNL173C MDG1 SGDID:S000005117, Chr XIV from 310057-308957, reverse complement, Verified ORF, "Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations"
>YNL174W YNL174W SGDID:S000005118, Chr XIV from 308074-308646, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene NOP13/YNL175C"
>YNL175C NOP13 SGDID:S000005119, Chr XIV from 308612-307401, reverse complement, Verified ORF, "Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM)"
>YNL176C YNL176C SGDID:S000005120, Chr XIV from 306980-305070, reverse complement, Uncharacterized ORF, "Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p"
>YNL177C MRPL22 SGDID:S000005121, Chr XIV from 304615-303686, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the large subunit"
>YNL178W RPS3 SGDID:S000005122, Chr XIV from 302680-303402, Verified ORF, "Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins"
>YNL179C YNL179C SGDID:S000005123, Chr XIV from 301103-300666, reverse complement, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance"
>YNL180C RHO5 SGDID:S000005124, Chr XIV from 300649-299654, reverse complement, Verified ORF, "Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity"
>YNL181W YNL181W SGDID:S000005125, Chr XIV from 298335-299558, Uncharacterized ORF, "Putative oxidoreductase; required for cell viability"
>YNL182C IPI3 SGDID:S000005126, Chr XIV from 297627-295960, reverse complement, Verified ORF, "Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; highly conserved and contains WD40 motifs; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles"
>YNL183C NPR1 SGDID:S000005127, Chr XIV from 295509-293137, reverse complement, Verified ORF, "Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation"
>YNL184C YNL184C SGDID:S000005128, Chr XIV from 292883-292557, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YNL185C MRPL19 SGDID:S000005129, Chr XIV from 292669-292193, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the large subunit"
>YNL186W UBP10 SGDID:S000005130, Chr XIV from 289498-291876, Verified ORF, "Ubiquitin-specific protease that deubiquitinates ubiquitin-protein moieties; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p and possibly other transporters; primarily located in the nucleus"
>YNL187W SWT21 SGDID:S000005131, Chr XIV from 287994-289067, Uncharacterized ORF, "Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats"
>YNL188W KAR1 SGDID:S000005132, Chr XIV from 286308-287609, Verified ORF, "Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p"
>YNL189W SRP1 SGDID:S000005133, Chr XIV from 284260-285888, Verified ORF, "Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation"
>YNL190W YNL190W SGDID:S000005134, Chr XIV from 282395-283009, Uncharacterized ORF, "Cell wall protein of unknown function; proposed role as a hydrophilin induced by osmotic stress; contains a putative GPI-attachment site"
>YNL191W DUG3 SGDID:S000005135, Chr XIV from 280432-281505, Verified ORF, "Probable glutamine amidotransferase, forms a complex with Dug1p and Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)"
>YNL192W CHS1 SGDID:S000005136, Chr XIV from 276502-279897, Verified ORF, "Chitin synthase I, requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for repairing the chitin septum during cytokinesis; transcription activated by mating factor"
>YNL193W YNL193W SGDID:S000005137, Chr XIV from 274368-276044, Uncharacterized ORF, "Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis"
>YNL194C YNL194C SGDID:S000005138, Chr XIV from 273615-272710, reverse complement, Verified ORF, "Integral membrane protein required for sporulation and plasma membrane sphingolipid content; has sequence similarity to SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS"
>YNL195C YNL195C SGDID:S000005139, Chr XIV from 272308-271523, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YNL196C SLZ1 SGDID:S000005140, Chr XIV from 271171-270275, reverse complement, Uncharacterized ORF, "Sporulation-specific protein with a leucine zipper motif"
>YNL197C WHI3 SGDID:S000005141, Chr XIV from 269593-267608, reverse complement, Verified ORF, "RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start"
>YNL198C YNL198C SGDID:S000005142, Chr XIV from 266816-266514, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YNL199C GCR2 SGDID:S000005143, Chr XIV from 266530-264926, reverse complement, Verified ORF, "Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p"
>YNL200C YNL200C SGDID:S000005144, Chr XIV from 264453-263713, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YNL201C PSY2 SGDID:S000005145, Chr XIV from 263203-260627, reverse complement, Verified ORF, "Putative subunit of an evolutionarily conserved protein phosphatase complex containing the catalytic subunit Pph3p and the regulatory subunit Psy4p; required for cisplatin and oxaliplatin resistance; putative homolog of mammalian R3"
>YNL202W SPS19 SGDID:S000005146, Chr XIV from 259578-260456, Verified ORF, "Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate"
>YNL203C YNL203C SGDID:S000005147, Chr XIV from 260050-259439, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YNL204C SPS18 SGDID:S000005148, Chr XIV from 259277-258375, reverse complement, Verified ORF, "Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation"
>YNL205C YNL205C SGDID:S000005149, Chr XIV from 258577-258155, reverse complement, Dubious ORF, "Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YNL206C RTT106 SGDID:S000005150, Chr XIV from 258155-256788, reverse complement, Verified ORF, "Histone chaperone, involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition"
>YNL207W RIO2 SGDID:S000005151, Chr XIV from 255353-256630, Verified ORF, "Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p"
>YNL208W YNL208W SGDID:S000005152, Chr XIV from 254418-255017, Verified ORF, "Protein of unknown function; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; potential orthologs found in other fungi"
>YNL209W SSB2 SGDID:S000005153, Chr XIV from 252059-253900, Verified ORF, "Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; homolog of SSB1"
>YNL210W MER1 SGDID:S000005154, Chr XIV from 250931-251743, Verified ORF, "Protein with RNA-binding motifs required for meiosis-specific mRNA splicing; required for chromosome pairing and meiotic recombination"
>YNL211C YNL211C SGDID:S000005155, Chr XIV from 250315-250055, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene"
>YNL212W VID27 SGDID:S000005156, Chr XIV from 247461-249809, Verified ORF, "Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth"
>YNL213C RRG9 SGDID:S000005157, Chr XIV from 247104-246460, reverse complement, Verified ORF, "Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YNL214W PEX17 SGDID:S000005158, Chr XIV from 245617-246216, Verified ORF, "Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis"
>YNL215W IES2 SGDID:S000005159, Chr XIV from 244468-245430, Verified ORF, "Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; essential for growth under anaerobic conditions"
>YNL216W RAP1 SGDID:S000005160, Chr XIV from 241689-244172, Verified ORF, "DNA-binding protein involved in either activation or repression of transcription, depending on binding site context; also binds telomere sequences and plays a role in telomeric position effect (silencing) and telomere structure"
>YNL217W YNL217W SGDID:S000005161, Chr XIV from 240331-241311, Uncharacterized ORF, "Putative protein of unknown function; weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate"
>YNL218W MGS1 SGDID:S000005162, Chr XIV from 238238-240001, Verified ORF, "Protein with DNA-dependent ATPase and ssDNA annealing activities involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP)"
>YNL219C ALG9 SGDID:S000005163, Chr XIV from 237663-235996, reverse complement, Verified ORF, "Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation"
>YNL220W ADE12 SGDID:S000005164, Chr XIV from 234413-235714, Verified ORF, "Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence"
>YNL221C POP1 SGDID:S000005165, Chr XIV from 233695-231068, reverse complement, Verified ORF, "Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in RNase P"
>YNL222W SSU72 SGDID:S000005166, Chr XIV from 229094-229714, Verified ORF, "Transcription/RNA-processing factor that associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 of the RNA polymerase II C-terminal domain; affects start site selection in vivo"
>YNL223W ATG4 SGDID:S000005167, Chr XIV from 227370-228854, Verified ORF, "Conserved cysteine protease required for autophagy; cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation"
>YNL224C SQS1 SGDID:S000005168, Chr XIV from 227099-224796, reverse complement, Verified ORF, "Stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles"
>YNL225C CNM67 SGDID:S000005169, Chr XIV from 224469-222724, reverse complement, Verified ORF, "Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration"
>YNL226W YNL226W SGDID:S000005170, Chr XIV from 222239-222649, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene JJJ1/YNL227C"
>YNL227C JJJ1 SGDID:S000005171, Chr XIV from 222431-220659, reverse complement, Verified ORF, "Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis"
>YNL228W YNL228W SGDID:S000005172, Chr XIV from 220645-221421, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1"
>YNL229C URE2 SGDID:S000005173, Chr XIV from 220201-219137, reverse complement, Verified ORF, "Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion"
>YNL230C ELA1 SGDID:S000005174, Chr XIV from 218662-217523, reverse complement, Verified ORF, "Elongin A, F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degredation of the RNA Polymerase II subunit RPO21; subunit of the Elongin-Cullin-Socs (ECS) ligase complex"
>YNL231C PDR16 SGDID:S000005175, Chr XIV from 217042-215987, reverse complement, Verified ORF, "Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17p"
>YNL232W CSL4 SGDID:S000005176, Chr XIV from 214923-215801, Verified ORF, "Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1)"
>YNL233W BNI4 SGDID:S000005177, Chr XIV from 211922-214600, Verified ORF, "Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p"
>YNL234W YNL234W SGDID:S000005178, Chr XIV from 210233-211513, Uncharacterized ORF, "Protein of unknown function with similarity to globins; has a functional heme-binding domain; mutant has aneuploidy tolerance; transcription induced by stress conditions; may be involved in glucose signaling or metabolism; regulated by Rgt1"
>YNL235C YNL235C SGDID:S000005179, Chr XIV from 209979-209548, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex"
>YNL236W SIN4 SGDID:S000005180, Chr XIV from 206930-209854, Verified ORF, "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription"
>YNL237W YTP1 SGDID:S000005181, Chr XIV from 205188-206567, Verified ORF, "Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins"
>YNL238W KEX2 SGDID:S000005182, Chr XIV from 202428-204872, Verified ORF, "Subtilisin-like protease (proprotein convertase), a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway"
>YNL239W LAP3 SGDID:S000005183, Chr XIV from 200569-201933, Verified ORF, "Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH"
>YNL240C NAR1 SGDID:S000005184, Chr XIV from 199977-198502, reverse complement, Verified ORF, "Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; homologous to human Narf"
>YNL241C ZWF1 SGDID:S000005185, Chr XIV from 197943-196426, reverse complement, Verified ORF, "Glucose-6-phosphate dehydrogenase (G6PD), catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia"
>YNL242W ATG2 SGDID:S000005186, Chr XIV from 191324-196102, Verified ORF, "Peripheral membrane protein required for vesicle formation during autophagy, pexophagy, and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria"
>YNL243W SLA2 SGDID:S000005187, Chr XIV from 188051-190957, Verified ORF, "Transmembrane actin-binding protein involved in membrane cytoskeleton assembly and cell polarization; adaptor protein that links actin to clathrin and endocytosis; present in the actin cortical patch of the emerging bud tip; dimer in vivo"
>YNL244C SUI1 SGDID:S000005188, Chr XIV from 187496-187170, reverse complement, Verified ORF, "Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase"
>YNL245C CWC25 SGDID:S000005189, Chr XIV from 186885-186346, reverse complement, Verified ORF, "Splicing factor required for the first step of pre-mRNA splicing; binding to the spliceosome requires Prp2p and Yju2p; heat-stable protein; has similarity to S. pombe Cwf25p"
>YNL246W VPS75 SGDID:S000005190, Chr XIV from 185460-185491,185587-186349, Verified ORF, "NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair"
>YNL247W YNL247W SGDID:S000005191, Chr XIV from 182875-185178, Verified ORF, "Cysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments"
>YNL248C RPA49 SGDID:S000005192, Chr XIV from 182608-181361, reverse complement, Verified ORF, "RNA polymerase I subunit A49"
>YNL249C MPA43 SGDID:S000005193, Chr XIV from 181022-179394, reverse complement, Verified ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YNL250W RAD50 SGDID:S000005194, Chr XIV from 175410-179348, Verified ORF, "Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining"
>YNL251C NRD1 SGDID:S000005195, Chr XIV from 174315-172588, reverse complement, Verified ORF, "RNA-binding protein that interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), preferentially at phosphorylated Ser5; required for transcription termination and 3' end maturation of nonpolyadenylated RNAs"
>YNL252C MRPL17 SGDID:S000005196, Chr XIV from 172286-171441, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the large subunit"
>YNL253W TEX1 SGDID:S000005197, Chr XIV from 170018-171286, Verified ORF, "Protein involved in mRNA export, component of the transcription export (TREX) complex"
>YNL254C RTC4 SGDID:S000005198, Chr XIV from 169248-168043, reverse complement, Verified ORF, "Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus"
>YNL255C GIS2 SGDID:S000005199, Chr XIV from 167790-167329, reverse complement, Verified ORF, "Protein with seven cysteine-rich CCHC zinc-finger motifs, similar to human CNBP, proposed to be involved in the RAS/cAMP signaling pathway; also has mRNA binding activity"
>YNL256W FOL1 SGDID:S000005200, Chr XIV from 164623-167097, Verified ORF, "Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities"
>YNL257C SIP3 SGDID:S000005201, Chr XIV from 164320-160631, reverse complement, Verified ORF, "Protein that activates transcription through interaction with DNA-bound Snf1p, C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate"
>YNL258C DSL1 SGDID:S000005202, Chr XIV from 160373-158109, reverse complement, Verified ORF, "Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; forms a complex with Sec39p and Tip20p that interacts with ER SNAREs Sec20p and Use1p; component of the ER target site that interacts with coatomer; interacts with Cin5p"
>YNL259C ATX1 SGDID:S000005203, Chr XIV from 157865-157644, reverse complement, Verified ORF, "Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake"
>YNL260C YNL260C SGDID:S000005204, Chr XIV from 157455-156859, reverse complement, Uncharacterized ORF, "Putative protein of unknown function with similarity to a human protein overexpressed in oral cancers; essential gene with defects in anaerobic and filamentous growth; localizes to the nucleus and cytoplasm"
>YNL261W ORC5 SGDID:S000005205, Chr XIV from 155100-156539, Verified ORF, "Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing"
>YNL262W POL2 SGDID:S000005206, Chr XIV from 148212-154880, Verified ORF, "Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p"
>YNL263C YIF1 SGDID:S000005207, Chr XIV from 147840-146896, reverse complement, Verified ORF, "Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles"
>YNL264C PDR17 SGDID:S000005208, Chr XIV from 146615-145563, reverse complement, Verified ORF, "Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition"
>YNL265C IST1 SGDID:S000005209, Chr XIV from 145149-144280,145281-145255, reverse complement, Verified ORF, "Protein with a positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p"
>YNL266W YNL266W SGDID:S000005210, Chr XIV from 144245-144664, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF IST1/YNL265C"
>YNL267W PIK1 SGDID:S000005211, Chr XIV from 140878-144078, Verified ORF, "Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton"
>YNL268W LYP1 SGDID:S000005212, Chr XIV from 138550-140385, Verified ORF, "Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids"
>YNL269W BSC4 SGDID:S000005213, Chr XIV from 137699-138094, Verified ORF, "Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p"
>YNL270C ALP1 SGDID:S000005214, Chr XIV from 137661-135940, reverse complement, Verified ORF, "Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression"
>YNL271C BNI1 SGDID:S000005215, Chr XIV from 135383-129522, reverse complement, Verified ORF, "Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1"
>YNL272C SEC2 SGDID:S000005216, Chr XIV from 129084-126805, reverse complement, Verified ORF, "Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles"
>YNL273W TOF1 SGDID:S000005217, Chr XIV from 122883-126599, Verified ORF, "Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase"
>YNL274C GOR1 SGDID:S000005218, Chr XIV from 122170-121118, reverse complement, Verified ORF, "Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YNL275W BOR1 SGDID:S000005219, Chr XIV from 119268-120998, Verified ORF, "Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1"
>YNL276C YNL276C SGDID:S000005220, Chr XIV from 118826-118431, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene MET2/YNL277W"
>YNL277W MET2 SGDID:S000005221, Chr XIV from 117349-118809, Verified ORF, "L-homoserine-O-acetyltransferase, catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway"
>YNL277W-A YNL277W-A SGDID:S000028852, Chr XIV from 116679-116867, Uncharacterized ORF, "Putative protein of unknown function"
>YNL278W CAF120 SGDID:S000005222, Chr XIV from 113271-116453, Verified ORF, "Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation"
>YNL279W PRM1 SGDID:S000005223, Chr XIV from 110917-112902, Verified ORF, "Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p"
>YNL280C ERG24 SGDID:S000005224, Chr XIV from 110411-109095, reverse complement, Verified ORF, "C-14 sterol reductase, acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions"
>YNL281W HCH1 SGDID:S000005225, Chr XIV from 108467-108928, Verified ORF, "Heat shock protein regulator that binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus"
>YNL282W POP3 SGDID:S000005226, Chr XIV from 107687-108274, Verified ORF, "Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends"
>YNL283C WSC2 SGDID:S000005227, Chr XIV from 106695-105184, reverse complement, Verified ORF, "Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response"
>YNL284C MRPL10 SGDID:S000005228, Chr XIV from 104102-103134, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels"
>YNL284C-A YNL284C-A SGDID:S000007386, Chr XIV from 102232-100910, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YNL284C-B YNL284C-B SGDID:S000007387, Chr XIV from 100926-96964,102232-100928, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YNL285W YNL285W SGDID:S000005229, Chr XIV from 96173-96544, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YNL286W CUS2 SGDID:S000005230, Chr XIV from 95223-96080, Verified ORF, "Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs)"
>YNL287W SEC21 SGDID:S000005231, Chr XIV from 91994-94801, Verified ORF, "Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo"
>YNL288W CAF40 SGDID:S000005232, Chr XIV from 90303-91424, Verified ORF, "Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p"
>YNL289W PCL1 SGDID:S000005233, Chr XIV from 87897-88736, Verified ORF, "Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth"
>YNL290W RFC3 SGDID:S000005234, Chr XIV from 86218-87240, Verified ORF, "Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon"
>YNL291C MID1 SGDID:S000005235, Chr XIV from 85815-84169, reverse complement, Verified ORF, "N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer"
>YNL292W PUS4 SGDID:S000005236, Chr XIV from 82806-84017, Verified ORF, "Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)"
>YNL293W MSB3 SGDID:S000005237, Chr XIV from 80640-82541, Verified ORF, "GTPase-activating protein for Sec4p and several other Rab GTPases, regulates exocytosis via its action on Sec4p, also required for proper actin organization; similar to Msb4p; both Msb3p and Msb4p localize to sites of polarized growth"
>YNL294C RIM21 SGDID:S000005238, Chr XIV from 80260-78659, reverse complement, Verified ORF, "Component of the RIM101 pathway, has a role in cell wall construction and alkaline pH response; has similarity to A. nidulans PalH"
>YNL295W YNL295W SGDID:S000005239, Chr XIV from 76946-78520, Uncharacterized ORF, "Putative protein of unknown function"
>YNL296W YNL296W SGDID:S000005240, Chr XIV from 76273-76587, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog"
>YNL297C MON2 SGDID:S000005241, Chr XIV from 76583-71673, reverse complement, Verified ORF, "Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins"
>YNL298W CLA4 SGDID:S000005242, Chr XIV from 68915-71443, Verified ORF, "Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p"
>YNL299W TRF5 SGDID:S000005243, Chr XIV from 66517-68445, Verified ORF, "Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p"
>YNL300W TOS6 SGDID:S000005244, Chr XIV from 65744-66052, Uncharacterized ORF, "Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid"
>YNL301C RPL18B SGDID:S000005245, Chr XIV from 64018-63570,64562-64451, reverse complement, Verified ORF, "Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein"
>YNL302C RPS19B SGDID:S000005246, Chr XIV from 62372-61958,62943-62924, reverse complement, Verified ORF, "Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Ap"
>YNL303W YNL303W SGDID:S000005247, Chr XIV from 61510-61857, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YNL304W YPT11 SGDID:S000005248, Chr XIV from 60297-61550, Verified ORF, "Rab family GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells"
>YNL305C YNL305C SGDID:S000005249, Chr XIV from 59791-58898, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL305C is not an essential gene"
>YNL306W MRPS18 SGDID:S000005250, Chr XIV from 58155-58808, Verified ORF, "Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins"
>YNL307C MCK1 SGDID:S000005251, Chr XIV from 57573-56446, reverse complement, Verified ORF, "Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis; related to mammalian glycogen synthase kinases of the GSK-3 family"
>YNL308C KRI1 SGDID:S000005252, Chr XIV from 55897-54122, reverse complement, Verified ORF, "Essential nucleolar protein required for 40S ribosome biogenesis; physically and functionally interacts with Krr1p"
>YNL309W STB1 SGDID:S000005253, Chr XIV from 52662-53924, Verified ORF, "Protein with a role in regulation of MBF-specific transcription at Start, phosphorylated by Cln-Cdc28p kinases in vitro; unphosphorylated form binds Swi6p and binding is required for Stb1p function; expression is cell-cycle regulated"
>YNL310C ZIM17 SGDID:S000005254, Chr XIV from 52431-51907, reverse complement, Verified ORF, "Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix"
>YNL311C SKP2 SGDID:S000005255, Chr XIV from 51688-49397, reverse complement, Verified ORF, "F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments"
>YNL312W RFA2 SGDID:S000005256, Chr XIV from 48287-48293,48402-49216, Verified ORF, "Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination"
>YNL313C EMW1 SGDID:S000005257, Chr XIV from 48022-45308, reverse complement, Uncharacterized ORF, "Essential protein of unknown function; fluorescent protein (GFP or YFP)-tagged protein localizes to cytoplasm and nucleus"
>YNL314W DAL82 SGDID:S000005258, Chr XIV from 44447-45214, Verified ORF, "Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain"
>YNL315C ATP11 SGDID:S000005259, Chr XIV from 44280-43324, reverse complement, Verified ORF, "Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase"
>YNL316C PHA2 SGDID:S000005260, Chr XIV from 43075-42071, reverse complement, Verified ORF, "Prephenate dehydratase, catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway"
>YNL317W PFS2 SGDID:S000005261, Chr XIV from 40619-42016, Verified ORF, "Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex"
>YNL318C HXT14 SGDID:S000005262, Chr XIV from 40329-38707, reverse complement, Verified ORF, "Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YNL319W YNL319W SGDID:S000005263, Chr XIV from 38642-39082, Dubious ORF, "Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14"
>YNL320W YNL320W SGDID:S000005264, Chr XIV from 37700-38554, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YNL321W VNX1 SGDID:S000005265, Chr XIV from 34696-37422, Verified ORF, "Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate"
>YNL322C KRE1 SGDID:S000005266, Chr XIV from 34235-33294, reverse complement, Verified ORF, "Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor"
>YNL323W LEM3 SGDID:S000005267, Chr XIV from 31944-33188, Verified ORF, "Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane"
>YNL324W YNL324W SGDID:S000005268, Chr XIV from 31050-31445, Dubious ORF, "Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YNL325C FIG4 SGDID:S000005269, Chr XIV from 31378-28739, reverse complement, Verified ORF, "Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain"
>YNL326C PFA3 SGDID:S000005270, Chr XIV from 28347-27337, reverse complement, Verified ORF, "Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions"
>YNL327W EGT2 SGDID:S000005271, Chr XIV from 24048-27173, Verified ORF, "Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner"
>YNL328C MDJ2 SGDID:S000005272, Chr XIV from 23274-22834, reverse complement, Verified ORF, "Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain"
>YNL329C PEX6 SGDID:S000005273, Chr XIV from 22633-19541, reverse complement, Verified ORF, "AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol"
>YNL330C RPD3 SGDID:S000005274, Chr XIV from 19302-18001, reverse complement, Verified ORF, "Histone deacetylase; regulates transcription, silencing, and other processes by influencing chromatin remodeling; forms at least two different complexes which have distinct functions and members"
>YNL331C AAD14 SGDID:S000005275, Chr XIV from 17248-16118, reverse complement, Verified ORF, "Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role"
>YNL332W THI12 SGDID:S000005276, Chr XIV from 14832-15854, Verified ORF, "Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13"
>YNL333W SNZ2 SGDID:S000005277, Chr XIV from 13267-14163, Verified ORF, "Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p"
>YNL334C SNO2 SGDID:S000005278, Chr XIV from 12876-12208, reverse complement, Verified ORF, "Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin"
>YNL335W DDI3 SGDID:S000005279, Chr XIV from 11452-12129, Uncharacterized ORF, "Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants"
>YNL336W COS1 SGDID:S000005280, Chr XIV from 8330-9475, Verified ORF, "Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins"
>YNL337W YNL337W SGDID:S000005281, Chr XIV from 7165-7419, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YNL338W YNL338W SGDID:S000005282, Chr XIV from 6561-6719, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV"
>YNL339C YRF1-6 SGDID:S000005283, Chr XIV from 5931-371,6098-6080, reverse complement, Verified ORF, "Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p"
>YNL339W-A YNL339W-A SGDID:S000028703, Chr XIV from 1517-2092, Dubious ORF, "Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YNL339W-B YNL339W-B SGDID:S000028704, Chr XIV from 734-1216, Dubious ORF, "Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YNR001C CIT1 SGDID:S000005284, Chr XIV from 631061-629622, reverse complement, Verified ORF, "Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein"
>YNR001W-A YNR001W-A SGDID:S000007625, Chr XIV from 631263-631481, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein; identified by homology"
>YNR002C ATO2 SGDID:S000005285, Chr XIV from 633856-633008, reverse complement, Verified ORF, "Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p"
>YNR003C RPC34 SGDID:S000005286, Chr XIV from 635297-634344, reverse complement, Verified ORF, "RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex"
>YNR003W-A YNR003W-A SGDID:S000028705, Chr XIV from 634420-634518, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene RPC34/YNR003C"
>YNR004W SWM2 SGDID:S000005287, Chr XIV from 635943-636383, Uncharacterized ORF, "Putative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds"
>YNR005C YNR005C SGDID:S000005288, Chr XIV from 637335-636931, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YNR006W VPS27 SGDID:S000005289, Chr XIV from 636986-638854, Verified ORF, "Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)"
>YNR007C ATG3 SGDID:S000005290, Chr XIV from 640114-639182, reverse complement, Verified ORF, "E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt"
>YNR008W LRO1 SGDID:S000005291, Chr XIV from 640396-642381, Verified ORF, "Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase"
>YNR009W NRM1 SGDID:S000005292, Chr XIV from 642690-643439, Verified ORF, "Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase"
>YNR010W CSE2 SGDID:S000005293, Chr XIV from 643744-644193, Verified ORF, "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; component of the Med9/10 module; required for regulation of RNA polymerase II activity"
>YNR011C PRP2 SGDID:S000005294, Chr XIV from 646950-644320, reverse complement, Verified ORF, "RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16"
>YNR012W URK1 SGDID:S000005295, Chr XIV from 647432-648937, Verified ORF, "Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP"
>YNR013C PHO91 SGDID:S000005296, Chr XIV from 651712-649028, reverse complement, Verified ORF, "Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth"
>YNR014W YNR014W SGDID:S000005297, Chr XIV from 652465-653103, Uncharacterized ORF, "Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible"
>YNR015W SMM1 SGDID:S000005298, Chr XIV from 653387-654541, Verified ORF, "Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs"
>YNR016C ACC1 SGDID:S000005299, Chr XIV from 661374-654673, reverse complement, Verified ORF, "Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids"
>YNR017W TIM23 SGDID:S000005300, Chr XIV from 662913-663581, Verified ORF, "Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel"
>YNR018W AIM38 SGDID:S000005301, Chr XIV from 664270-664944, Verified ORF, "Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; may interact with respiratory chain complex IV; null mutant is viable and displays reduced frequency of mitochondrial genome loss"
>YNR019W ARE2 SGDID:S000005302, Chr XIV from 665339-667267, Verified ORF, "Acyl-CoA:sterol acyltransferase, isozyme of Are1p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen"
>YNR020C ATP23 SGDID:S000005303, Chr XIV from 668222-667410, reverse complement, Verified ORF, "Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex"
>YNR021W YNR021W SGDID:S000005304, Chr XIV from 668377-669591, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene"
>YNR022C MRPL50 SGDID:S000005305, Chr XIV from 670193-669774, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation"
>YNR023W SNF12 SGDID:S000005306, Chr XIV from 670418-672118, Verified ORF, "73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; deletion mutants are temperature-sensitive"
>YNR024W MPP6 SGDID:S000005307, Chr XIV from 672409-672969, Verified ORF, "Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes"
>YNR025C YNR025C SGDID:S000005308, Chr XIV from 673061-672702, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion reduces expression of PIS1 gene encoding phosphatidylinositol synthase"
>YNR026C SEC12 SGDID:S000005309, Chr XIV from 674689-673274, reverse complement, Verified ORF, "Guanine nucleotide exchange factor (GEF), activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER"
>YNR027W BUD17 SGDID:S000005310, Chr XIV from 674923-675876, Verified ORF, "Putative pyridoxal kinase, a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK)"
>YNR028W CPR8 SGDID:S000005311, Chr XIV from 676177-677103, Verified ORF, "Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway"
>YNR029C YNR029C SGDID:S000005312, Chr XIV from 678488-677199, reverse complement, Uncharacterized ORF, "Putative protein of unknown function, deletion confers reduced fitness in saline"
>YNR030W ALG12 SGDID:S000005313, Chr XIV from 678799-680454, Verified ORF, "Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation"
>YNR031C SSK2 SGDID:S000005314, Chr XIV from 685433-680694, reverse complement, Verified ORF, "MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress"
>YNR032C-A HUB1 SGDID:S000007251, Chr XIV from 687464-687243, reverse complement, Verified ORF, "Ubiquitin-like protein modifier, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear"
>YNR032W PPG1 SGDID:S000005315, Chr XIV from 686010-687116, Verified ORF, "Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases"
>YNR033W ABZ1 SGDID:S000005316, Chr XIV from 687635-689998, Verified ORF, "Para-aminobenzoate (PABA) synthase, has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis"
>YNR034W SOL1 SGDID:S000005317, Chr XIV from 690321-691286, Verified ORF, "Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol2p, Sol3p, and Sol4p"
>YNR034W-A YNR034W-A SGDID:S000007525, Chr XIV from 692561-692857, Uncharacterized ORF, "Putative protein of unknown function; expression is regulated by Msn2p/Msn4p"
>YNR035C ARC35 SGDID:S000005318, Chr XIV from 694047-693019, reverse complement, Verified ORF, "Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin"
>YNR036C MRPS12 SGDID:S000005319, Chr XIV from 694822-694361, reverse complement, Verified ORF, "Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins"
>YNR037C RSM19 SGDID:S000005320, Chr XIV from 695327-695052, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein"
>YNR038W DBP6 SGDID:S000005321, Chr XIV from 695595-697484, Verified ORF, "Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family"
>YNR039C ZRG17 SGDID:S000005322, Chr XIV from 699431-697614, reverse complement, Verified ORF, "Endoplasmic reticulum protein of unknown function, transcription is induced under conditions of zinc deficiency; mutant phenotype suggests a role in uptake of zinc"
>YNR040W YNR040W SGDID:S000005323, Chr XIV from 699690-700460, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YNR041C COQ2 SGDID:S000005324, Chr XIV from 701659-700541, reverse complement, Verified ORF, "Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis"
>YNR042W YNR042W SGDID:S000005325, Chr XIV from 701238-701666, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2"
>YNR043W MVD1 SGDID:S000005326, Chr XIV from 701895-703085, Verified ORF, "Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer"
>YNR044W AGA1 SGDID:S000005327, Chr XIV from 703699-705876, Verified ORF, "Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds"
>YNR045W PET494 SGDID:S000005328, Chr XIV from 706139-707608, Verified ORF, "Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane"
>YNR046W TRM112 SGDID:S000005329, Chr XIV from 707788-708195, Verified ORF, "Subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; deletion confers resistance to zymocin"
>YNR047W FPK1 SGDID:S000005330, Chr XIV from 708523-711204, Verified ORF, "Ser/Thr protein kinase that regulates the putative phospholipid translocases Lem3p-Dnf1p/Dnf2p; phosphorylates and inhibits upstream inhibitory kinase, Ypk1p; localizes to the cytoplasm, early endosome/TGN compartments, and plasma membrane"
>YNR048W YNR048W SGDID:S000005331, Chr XIV from 711630-712811, Verified ORF, "Protein that interacts specifically in vivo with phospholipid translocase (flippase) Dnf3p; similar to Cdc50p, which is an essential interaction partner of the flippase Drs2p"
>YNR049C MSO1 SGDID:S000005332, Chr XIV from 713655-713023, reverse complement, Verified ORF, "Probable component of the secretory vesicle docking complex, acts at a late step in secretion; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation"
>YNR050C LYS9 SGDID:S000005333, Chr XIV from 715388-714048, reverse complement, Verified ORF, "Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112"
>YNR051C BRE5 SGDID:S000005334, Chr XIV from 718327-716780, reverse complement, Verified ORF, "Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A"
>YNR052C POP2 SGDID:S000005335, Chr XIV from 720647-719346, reverse complement, Verified ORF, "RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation"
>YNR053C NOG2 SGDID:S000005336, Chr XIV from 721770-721120,723112-722303, reverse complement, Verified ORF, "Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation"
>YNR054C ESF2 SGDID:S000005337, Chr XIV from 724306-723356, reverse complement, Verified ORF, "Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome"
>YNR055C HOL1 SGDID:S000005338, Chr XIV from 730186-728426, reverse complement, Verified ORF, "Putative transporter in the major facilitator superfamily (DHA1 family) of multidrug resistance transporters; mutations in membrane-spanning domains permit cation and histidinol uptake"
>YNR056C BIO5 SGDID:S000005339, Chr XIV from 733303-731618, reverse complement, Verified ORF, "Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis"
>YNR057C BIO4 SGDID:S000005340, Chr XIV from 734069-733356, reverse complement, Verified ORF, "Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels"
>YNR058W BIO3 SGDID:S000005341, Chr XIV from 734291-735733, Verified ORF, "7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis"
>YNR059W MNT4 SGDID:S000005342, Chr XIV from 736803-738545, Verified ORF, "Putative alpha-1,3-mannosyltransferase, not required for protein O-glycosylation"
>YNR060W FRE4 SGDID:S000005343, Chr XIV from 739951-742110, Verified ORF, "Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels"
>YNR061C YNR061C SGDID:S000005344, Chr XIV from 743540-742881, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YNR062C YNR062C SGDID:S000005345, Chr XIV from 745343-744360, reverse complement, Uncharacterized ORF, "Putative membrane protein of unknown function"
>YNR063W YNR063W SGDID:S000005346, Chr XIV from 746943-748766, Uncharacterized ORF, "Putative zinc-cluster protein of unknown function"
>YNR064C YNR064C SGDID:S000005347, Chr XIV from 750008-749136, reverse complement, Verified ORF, "Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides"
>YNR065C YNR065C SGDID:S000005348, Chr XIV from 753700-750350, reverse complement, Uncharacterized ORF, "Protein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene"
>YNR066C YNR066C SGDID:S000005349, Chr XIV from 755035-753725, reverse complement, Uncharacterized ORF, "Putative membrane-localized protein of unknown function"
>YNR067C DSE4 SGDID:S000005350, Chr XIV from 759099-755746, reverse complement, Verified ORF, "Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother"
>YNR068C YNR068C SGDID:S000005351, Chr XIV from 760885-760067, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YNR069C BSC5 SGDID:S000005352, Chr XIV from 762592-761123, reverse complement, Verified ORF, "Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression"
>YNR070W PDR18 SGDID:S000005353, Chr XIV from 765375-769376, Uncharacterized ORF, "Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YNR071C YNR071C SGDID:S000005354, Chr XIV from 771468-770440, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YNR072W HXT17 SGDID:S000005355, Chr XIV from 772657-774351, Verified ORF, "Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose"
>YNR073C YNR073C SGDID:S000005356, Chr XIV from 776300-774792, reverse complement, Uncharacterized ORF, "Putative mannitol dehydrogenase"
>YNR074C AIF1 SGDID:S000005357, Chr XIV from 778738-777602, reverse complement, Verified ORF, "Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase"
>YNR075C-A YNR075C-A SGDID:S000028706, Chr XIV from 781603-781511, reverse complement, Uncharacterized ORF, "Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YNR075W COS10 SGDID:S000005358, Chr XIV from 779916-781040, Verified ORF, "Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins"
>YNR076W PAU6 SGDID:S000005359, Chr XIV from 781918-782280, Verified ORF, "Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme; identical to Pau18p"
>YNR077C YNR077C SGDID:S000005360, Chr XIV from 783541-783287, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YOL001W PHO80 SGDID:S000005361, Chr XV from 325249-326130, Verified ORF, "Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling"
>YOL002C IZH2 SGDID:S000005362, Chr XV from 324364-323411, reverse complement, Verified ORF, "Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc"
>YOL003C PFA4 SGDID:S000005363, Chr XV from 322994-321858, reverse complement, Verified ORF, "Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases"
>YOL004W SIN3 SGDID:S000005364, Chr XV from 316938-321548, Verified ORF, "Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity"
>YOL005C RPB11 SGDID:S000005365, Chr XV from 316175-315813, reverse complement, Verified ORF, "RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit"
>YOL006C TOP1 SGDID:S000005366, Chr XV from 315387-313078, reverse complement, Verified ORF, "Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination"
>YOL007C CSI2 SGDID:S000005367, Chr XV from 312367-311342, reverse complement, Verified ORF, "Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene"
>YOL008W COQ10 SGDID:S000005368, Chr XV from 310312-310935, Verified ORF, "Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q<sub>6</sub> to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes"
>YOL009C MDM12 SGDID:S000005369, Chr XV from 310139-309324, reverse complement, Verified ORF, "Mitochondrial outer membrane protein, required for transmission of mitochondria to daughter cells; component of the ERMES complex that links the ER to mitochondria; may influence import and assembly of outer membrane beta-barrel proteins"
>YOL010W RCL1 SGDID:S000005370, Chr XV from 307938-309041, Verified ORF, "Subunit of U3-containing 90S preribosome processome complex involved in 18S rRNA biogenesis and small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no activity detected"
>YOL011W PLB3 SGDID:S000005371, Chr XV from 305349-307409, Verified ORF, "Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro"
>YOL012C HTZ1 SGDID:S000005372, Chr XV from 303983-303579, reverse complement, Verified ORF, "Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin"
>YOL013C HRD1 SGDID:S000005373, Chr XV from 303035-301380, reverse complement, Verified ORF, "Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger"
>YOL013W-A YOL013W-A SGDID:S000028811, Chr XV from 301047-301238, Uncharacterized ORF, "Putative protein of unknown function; identified by SAGE"
>YOL013W-B YOL013W-B SGDID:S000007252, Chr XV from 300690-300980, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the long terminal repeat (LTR) of a Ty1 element"
>YOL014W YOL014W SGDID:S000005374, Chr XV from 299693-300067, Uncharacterized ORF, "Putative protein of unknown function"
>YOL015W IRC10 SGDID:S000005375, Chr XV from 297078-298838, Verified ORF, "Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci"
>YOL016C CMK2 SGDID:S000005376, Chr XV from 296120-294777, reverse complement, Verified ORF, "Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk1p and mammalian Cam Kinase II"
>YOL017W ESC8 SGDID:S000005377, Chr XV from 292529-294673, Verified ORF, "Protein involved in telomeric and mating-type locus silencing, interacts with Sir2p and also interacts with the Gal11p, which is a component of the RNA pol II mediator complex"
>YOL018C TLG2 SGDID:S000005378, Chr XV from 292074-290881, reverse complement, Verified ORF, "Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation"
>YOL019W YOL019W SGDID:S000005379, Chr XV from 288898-290553, Uncharacterized ORF, "Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole"
>YOL019W-A YOL019W-A SGDID:S000028707, Chr XV from 288420-288572, Uncharacterized ORF, "Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YOL020W TAT2 SGDID:S000005380, Chr XV from 286172-287950, Verified ORF, "High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance"
>YOL021C DIS3 SGDID:S000005381, Chr XV from 285426-282421, reverse complement, Verified ORF, "Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3"
>YOL022C TSR4 SGDID:S000005382, Chr XV from 281498-280272, reverse complement, Verified ORF, "Cytoplasmic protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2"
>YOL023W IFM1 SGDID:S000005383, Chr XV from 278056-280086, Verified ORF, "Mitochondrial translation initiation factor 2"
>YOL024W YOL024W SGDID:S000005384, Chr XV from 277086-277604, Uncharacterized ORF, "Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site"
>YOL025W LAG2 SGDID:S000005385, Chr XV from 274957-276939, Verified ORF, "Protein that negatively regulates the SCF E3-ubiquitin ligase by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1"
>YOL026C MIM1 SGDID:S000005386, Chr XV from 274353-274012, reverse complement, Verified ORF, "Mitochondrial outer membrane protein, required for assembly of the translocase of the outer membrane (TOM) complex and thereby for mitochondrial protein import; N terminus is exposed to the cytosol: transmembrane segment is highly conserved"
>YOL027C MDM38 SGDID:S000005387, Chr XV from 273724-272003, reverse complement, Verified ORF, "Mitochondrial inner membrane protein, involved in membrane integration of a subset of mitochondrial proteins; required for K+/H+ exchange; associates with mitochondrial ribosomes; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome"
>YOL028C YAP7 SGDID:S000005388, Chr XV from 271370-270633, reverse complement, Verified ORF, "Putative basic leucine zipper (bZIP) transcription factor"
>YOL029C YOL029C SGDID:S000005389, Chr XV from 270420-269815, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens"
>YOL030W GAS5 SGDID:S000005390, Chr XV from 268187-269641, Verified ORF, "1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall"
>YOL031C SIL1 SGDID:S000005391, Chr XV from 267529-266264, reverse complement, Verified ORF, "Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein"
>YOL032W OPI10 SGDID:S000005392, Chr XV from 265429-266169, Verified ORF, "Protein with a possible role in phospholipid biosynthesis, based on inositol-excreting phenotype of the null mutant and its suppression by exogenous choline"
>YOL033W MSE1 SGDID:S000005393, Chr XV from 263475-265085, Verified ORF, "Mitochondrial glutamyl-tRNA synthetase, predicted to be palmitoylated"
>YOL034W SMC5 SGDID:S000005394, Chr XV from 259923-263204, Verified ORF, "Structural maintenance of chromosomes (SMC) protein; essential subunit of the Mms21-Smc5-Smc6 complex; required for growth and DNA repair; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair"
>YOL035C YOL035C SGDID:S000005395, Chr XV from 259105-258803, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YOL036W YOL036W SGDID:S000005396, Chr XV from 256745-259030, Uncharacterized ORF, "Protein of unknown function; potential Cdc28p substrate"
>YOL037C YOL037C SGDID:S000005397, Chr XV from 257019-256666, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W"
>YOL038C-A YOL038C-A SGDID:S000028812, Chr XV from 255021-254926, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by SAGE analysis"
>YOL038W PRE6 SGDID:S000005398, Chr XV from 255337-256101, Verified ORF, "Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress"
>YOL039W RPP2A SGDID:S000005399, Chr XV from 254297-254617, Verified ORF, "Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm"
>YOL040C RPS15 SGDID:S000005400, Chr XV from 253577-253149, reverse complement, Verified ORF, "Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S19 and rat S15 ribosomal proteins"
>YOL041C NOP12 SGDID:S000005401, Chr XV from 252646-251267, reverse complement, Verified ORF, "Nucleolar protein involved in pre-25S rRNA processing and biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p"
>YOL042W NGL1 SGDID:S000005402, Chr XV from 249825-250916, Verified ORF, "Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YOL043C NTG2 SGDID:S000005403, Chr XV from 249534-248392, reverse complement, Verified ORF, "DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair, localizes to the nucleus; sumoylated"
>YOL044W PEX15 SGDID:S000005404, Chr XV from 247150-248301, Verified ORF, "Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly"
>YOL045W PSK2 SGDID:S000005405, Chr XV from 243497-246802, Verified ORF, "One of two (see also PSK1) PAS domain containing S/T protein kinases; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation)"
>YOL046C YOL046C SGDID:S000005406, Chr XV from 244140-243466, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data;almost completely overlaps the verified gene PSK2/YOL045W"
>YOL047C YOL047C SGDID:S000005407, Chr XV from 242441-241614,242747-242505, reverse complement, Uncharacterized ORF, "Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern"
>YOL048C RRT8 SGDID:S000005408, Chr XV from 240947-240204,241310-241026, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles"
>YOL049W GSH2 SGDID:S000005409, Chr XV from 238619-240094, Verified ORF, "Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock"
>YOL050C YOL050C SGDID:S000005410, Chr XV from 238202-237882, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)"
>YOL051W GAL11 SGDID:S000005411, Chr XV from 234940-238185, Verified ORF, "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors"
>YOL052C SPE2 SGDID:S000005412, Chr XV from 233636-232446, reverse complement, Verified ORF, "S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically"
>YOL052C-A DDR2 SGDID:S000005413, Chr XV from 231755-231570, reverse complement, Verified ORF, "Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses"
>YOL053W AIM39 SGDID:S000005414, Chr XV from 230085-231272, Verified ORF, "Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss"
>YOL054W PSH1 SGDID:S000005415, Chr XV from 228614-229834, Verified ORF, "E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p"
>YOL055C THI20 SGDID:S000005416, Chr XV from 226075-224420, reverse complement, Verified ORF, "Multifunctional protein with hydroxymethylpyrimidine phosphate (HMP-P) kinase and thiaminase activities; involved in thiamine biosynthesis and degradation; in a gene family with THI21 and THI22; HMP-P kinase activity redundant with Thi21p"
>YOL056W GPM3 SGDID:S000005417, Chr XV from 223268-224179, Verified ORF, "Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event"
>YOL057W YOL057W SGDID:S000005418, Chr XV from 220767-222902, Verified ORF, "Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers"
>YOL058W ARG1 SGDID:S000005419, Chr XV from 219211-220473, Verified ORF, "Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate"
>YOL059W GPD2 SGDID:S000005420, Chr XV from 217126-218448, Verified ORF, "NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria"
>YOL060C MAM3 SGDID:S000005421, Chr XV from 216137-214017, reverse complement, Verified ORF, "Protein required for normal mitochondrial morphology, has similarity to hemolysins"
>YOL061W PRS5 SGDID:S000005422, Chr XV from 212244-213734, Verified ORF, "5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes"
>YOL062C APM4 SGDID:S000005423, Chr XV from 211995-210520, reverse complement, Verified ORF, "Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport"
>YOL063C CRT10 SGDID:S000005424, Chr XV from 210265-207392, reverse complement, Verified ORF, "Protein involved in transcriptional regulation of RNR2 and RNR3; expression of the gene is induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat"
>YOL064C MET22 SGDID:S000005425, Chr XV from 207176-206103, reverse complement, Verified ORF, "Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway"
>YOL065C INP54 SGDID:S000005426, Chr XV from 205885-204731, reverse complement, Verified ORF, "Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins"
>YOL066C RIB2 SGDID:S000005427, Chr XV from 204471-202696, reverse complement, Verified ORF, "Bifunctional enzyme with DRAP deaminase and tRNA:pseudouridine synthase activity; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs"
>YOL067C RTG1 SGDID:S000005428, Chr XV from 202518-201985, reverse complement, Verified ORF, "Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus"
>YOL068C HST1 SGDID:S000005429, Chr XV from 201879-200368, reverse complement, Verified ORF, "NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance"
>YOL069W NUF2 SGDID:S000005430, Chr XV from 198942-200297, Verified ORF, "Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering"
>YOL070C NBA1 SGDID:S000005431, Chr XV from 198725-197220, reverse complement, Verified ORF, "Protein of unknown function, localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate"
>YOL071W EMI5 SGDID:S000005432, Chr XV from 196507-196995, Verified ORF, "Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)"
>YOL072W THP1 SGDID:S000005433, Chr XV from 194970-196337, Verified ORF, "Nuclear pore-associated protein, forms a complex with Sac3p that is involved in transcription and in mRNA export from the nucleus; contains a PAM domain implicated in protein-protein binding"
>YOL073C YOL073C SGDID:S000005434, Chr XV from 194800-193832, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YOL075C YOL075C SGDID:S000005435, Chr XV from 193542-189658, reverse complement, Uncharacterized ORF, "Putative ABC transporter"
>YOL076W MDM20 SGDID:S000005436, Chr XV from 187024-189414, Verified ORF, "Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly"
>YOL077C BRX1 SGDID:S000005437, Chr XV from 186723-185848, reverse complement, Verified ORF, "Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif"
>YOL077W-A ATP19 SGDID:S000007339, Chr XV from 185438-185644, Verified ORF, "Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase"
>YOL078W AVO1 SGDID:S000005438, Chr XV from 181682-185212, Verified ORF, "Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth"
>YOL079W YOL079W SGDID:S000005439, Chr XV from 181057-181455, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YOL080C REX4 SGDID:S000005440, Chr XV from 181427-180558, reverse complement, Verified ORF, "Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly"
>YOL081W IRA2 SGDID:S000005441, Chr XV from 171070-180309, Verified ORF, "GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin"
>YOL082W ATG19 SGDID:S000005442, Chr XV from 168727-169974, Verified ORF, "Receptor protein specific for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles"
>YOL083C-A YOL083C-A SGDID:S000028853, Chr XV from 166601-166461, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry"
>YOL083W ATG34 SGDID:S000005443, Chr XV from 165714-166952, Verified ORF, "Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog"
>YOL084W PHM7 SGDID:S000005444, Chr XV from 162356-165331, Verified ORF, "Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole"
>YOL085C YOL085C SGDID:S000005445, Chr XV from 162014-161673, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A"
>YOL085W-A YOL085W-A SGDID:S000028708, Chr XV from 161579-161791, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C"
>YOL086C ADH1 SGDID:S000005446, Chr XV from 160594-159548, reverse complement, Verified ORF, "Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway"
>YOL086W-A YOL086W-A SGDID:S000007626, Chr XV from 159173-159445, Uncharacterized ORF, "Putative protein of unknown function; mutant in a srs2 mutant background displays MMS hypersensitivity; ortholog of human MHF1, a component of the Fanconi anemia (FA) complex that is involved in maintaining genome stability"
>YOL087C YOL087C SGDID:S000005447, Chr XV from 158637-155287, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid"
>YOL088C MPD2 SGDID:S000005448, Chr XV from 154745-153912, reverse complement, Verified ORF, "Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p"
>YOL089C HAL9 SGDID:S000005449, Chr XV from 153490-150398, reverse complement, Verified ORF, "Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression"
>YOL090W MSH2 SGDID:S000005450, Chr XV from 147382-150276, Verified ORF, "Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP"
>YOL091W SPO21 SGDID:S000005451, Chr XV from 145334-147163, Verified ORF, "Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation"
>YOL092W YOL092W SGDID:S000005452, Chr XV from 144204-145130, Uncharacterized ORF, "Putative protein of unknown function; predicted to contain six transmembrane domains and is 58% similar to the uncharacterized ORF YBR147W"
>YOL093W TRM10 SGDID:S000005453, Chr XV from 142815-143696, Verified ORF, "tRNA methyltransferase, methylates the N-1 position of guanosine in tRNAs"
>YOL094C RFC4 SGDID:S000005454, Chr XV from 142555-141584, reverse complement, Verified ORF, "Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon"
>YOL095C HMI1 SGDID:S000005455, Chr XV from 141347-139227, reverse complement, Verified ORF, "Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD"
>YOL096C COQ3 SGDID:S000005456, Chr XV from 139045-138107, reverse complement, Verified ORF, "O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein"
>YOL097C WRS1 SGDID:S000005457, Chr XV from 137825-136527, reverse complement, Verified ORF, "Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA"
>YOL097W-A YOL097W-A SGDID:S000028854, Chr XV from 136220-136405, Uncharacterized ORF, "Putative protein of unknown function; identified by expression profiling and mass spectrometry"
>YOL098C YOL098C SGDID:S000005458, Chr XV from 135838-132725, reverse complement, Uncharacterized ORF, "Putative metalloprotease"
>YOL099C YOL099C SGDID:S000005459, Chr XV from 132508-132017, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PKH2/YOL100W; may interact with ribosomes"
>YOL100W PKH2 SGDID:S000005460, Chr XV from 129237-132482, Verified ORF, "Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p"
>YOL101C IZH4 SGDID:S000005461, Chr XV from 127920-126982, reverse complement, Verified ORF, "Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism"
>YOL102C TPT1 SGDID:S000005462, Chr XV from 126689-125997, reverse complement, Verified ORF, "tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide"
>YOL103W ITR2 SGDID:S000005463, Chr XV from 124001-125830, Verified ORF, "Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively"
>YOL103W-A YOL103W-A SGDID:S000007349, Chr XV from 118000-119322, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YOL103W-B YOL103W-B SGDID:S000007350, Chr XV from 118000-119304,119306-123268, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YOL104C NDJ1 SGDID:S000005464, Chr XV from 117454-116396, reverse complement, Verified ORF, "Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement"
>YOL105C WSC3 SGDID:S000005465, Chr XV from 115808-114138, reverse complement, Verified ORF, "Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis"
>YOL106W YOL106W SGDID:S000005466, Chr XV from 113226-113579, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YOL107W YOL107W SGDID:S000005467, Chr XV from 112102-113130, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein"
>YOL108C INO4 SGDID:S000005468, Chr XV from 111886-111431, reverse complement, Verified ORF, "Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain"
>YOL109W ZEO1 SGDID:S000005469, Chr XV from 110297-110638, Verified ORF, "Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria"
>YOL110W SHR5 SGDID:S000005470, Chr XV from 109176-109889, Verified ORF, "Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization"
>YOL111C MDY2 SGDID:S000005471, Chr XV from 108896-108258, reverse complement, Verified ORF, "Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes"
>YOL112W MSB4 SGDID:S000005472, Chr XV from 106710-108188, Verified ORF, "GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization"
>YOL113W SKM1 SGDID:S000005473, Chr XV from 104326-106293, Verified ORF, "Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth"
>YOL114C YOL114C SGDID:S000005474, Chr XV from 103925-103317, reverse complement, Uncharacterized ORF, "Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene"
>YOL115W PAP2 SGDID:S000005475, Chr XV from 101475-103229, Verified ORF, "Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Trf5p"
>YOL116W MSN1 SGDID:S000005476, Chr XV from 99809-100957, Verified ORF, "Transcriptional activator involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus"
>YOL117W RRI2 SGDID:S000005477, Chr XV from 97551-99488, Verified ORF, "Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response"
>YOL118C YOL118C SGDID:S000005478, Chr XV from 96916-96608, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YOL119C MCH4 SGDID:S000005479, Chr XV from 96361-94856, reverse complement, Verified ORF, "Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport"
>YOL120C RPL18A SGDID:S000005480, Chr XV from 93843-93395,94402-94291, reverse complement, Verified ORF, "Protein component of the large (60S) ribosomal subunit, identical to Rpl18Bp and has similarity to rat L18 ribosomal protein; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation"
>YOL121C RPS19A SGDID:S000005481, Chr XV from 92440-92026,92850-92831, reverse complement, Verified ORF, "Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Bp"
>YOL122C SMF1 SGDID:S000005482, Chr XV from 91419-89692, reverse complement, Verified ORF, "Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins"
>YOL123W HRP1 SGDID:S000005483, Chr XV from 87844-89448, Verified ORF, "Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences"
>YOL124C TRM11 SGDID:S000005484, Chr XV from 86757-85456, reverse complement, Verified ORF, "Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain"
>YOL125W TRM13 SGDID:S000005485, Chr XV from 83834-85264, Verified ORF, "2'-O-methyltransferase responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases"
>YOL126C MDH2 SGDID:S000005486, Chr XV from 82920-81787, reverse complement, Verified ORF, "Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1"
>YOL127W RPL25 SGDID:S000005487, Chr XV from 80348-80360,80775-81190, Verified ORF, "Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal motif"
>YOL128C YGK3 SGDID:S000005488, Chr XV from 79479-78352, reverse complement, Verified ORF, "Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation"
>YOL129W VPS68 SGDID:S000005489, Chr XV from 77560-78114, Verified ORF, "Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria"
>YOL130W ALR1 SGDID:S000005490, Chr XV from 74400-76979, Verified ORF, "Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions"
>YOL131W YOL131W SGDID:S000005491, Chr XV from 73031-73357, Uncharacterized ORF, "Putative protein of unknown function"
>YOL132W GAS4 SGDID:S000005492, Chr XV from 71300-72715, Verified ORF, "1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall"
>YOL133W HRT1 SGDID:S000005493, Chr XV from 70325-70690, Verified ORF, "RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF"
>YOL134C YOL134C SGDID:S000005494, Chr XV from 70545-70156, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps HRT1, a verified gene that encodes an SCF ubiquitin ligase subunit"
>YOL135C MED7 SGDID:S000005495, Chr XV from 70044-69376, reverse complement, Verified ORF, "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation"
>YOL136C PFK27 SGDID:S000005496, Chr XV from 68754-67561, reverse complement, Verified ORF, "6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A"
>YOL137W BSC6 SGDID:S000005497, Chr XV from 65621-67114, Verified ORF, "Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression"
>YOL138C RTC1 SGDID:S000005498, Chr XV from 65350-61325, reverse complement, Verified ORF, "Protein of unknown function; may interact with ribosomes, based on co-purification experiments; null mutation suppresses cdc13-1 temperature sensitivity"
>YOL139C CDC33 SGDID:S000005499, Chr XV from 61024-60383, reverse complement, Verified ORF, "Cytoplasmic mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p)"
>YOL140W ARG8 SGDID:S000005500, Chr XV from 58759-60030, Verified ORF, "Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine"
>YOL141W PPM2 SGDID:S000005501, Chr XV from 56452-58539, Verified ORF, "AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p"
>YOL142W RRP40 SGDID:S000005502, Chr XV from 55558-56280, Verified ORF, "Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain both S1 and KH RNA binding domains; has similarity to human hRrp40p (EXOSC3)"
>YOL143C RIB4 SGDID:S000005503, Chr XV from 55104-54595, reverse complement, Verified ORF, "Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin"
>YOL144W NOP8 SGDID:S000005504, Chr XV from 53098-54552, Verified ORF, "Nucleolar protein required for 60S ribosomal subunit biogenesis"
>YOL145C CTR9 SGDID:S000005505, Chr XV from 52788-49555, reverse complement, Verified ORF, "Component of the Paf1p complex that binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; contains TPR repeats"
>YOL146W PSF3 SGDID:S000005506, Chr XV from 48864-49448, Verified ORF, "Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery"
>YOL147C PEX11 SGDID:S000005507, Chr XV from 48643-47933, reverse complement, Verified ORF, "Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p"
>YOL148C SPT20 SGDID:S000005508, Chr XV from 47574-45760, reverse complement, Verified ORF, "Subunit of the SAGA transcriptional regulatory complex, involved in maintaining the integrity of the complex"
>YOL149W DCP1 SGDID:S000005509, Chr XV from 44938-45633, Verified ORF, "Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p"
>YOL150C YOL150C SGDID:S000005510, Chr XV from 44784-44473, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YOL151W GRE2 SGDID:S000005511, Chr XV from 43694-44722, Verified ORF, "3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway"
>YOL152W FRE7 SGDID:S000005512, Chr XV from 40748-42610, Verified ORF, "Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels"
>YOL153C YOL153C SGDID:S000005513, Chr XV from 38567-36822, reverse complement, pseudogene, "Hypothetical protein"
>YOL154W ZPS1 SGDID:S000005514, Chr XV from 34658-35407, Verified ORF, "Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH"
>YOL155C HPF1 SGDID:S000005515, Chr XV from 31606-28703, reverse complement, Verified ORF, "Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines"
>YOL155W-A YOL155W-A SGDID:S000028855, Chr XV from 27084-27218, Uncharacterized ORF, "Putative protein of unknown function; identified by expression profiling and mass spectrometry"
>YOL156W HXT11 SGDID:S000005516, Chr XV from 25273-26976, Verified ORF, "Putative hexose transporter that is nearly identical to Hxt9p, has similarity to major facilitator superfamily (MFS) transporters and is involved in pleiotropic drug resistance"
>YOL157C IMA2 SGDID:S000005517, Chr XV from 24294-22525, reverse complement, Verified ORF, "Alpha-glucosidase with specificity for isomaltase, methyl-alpha-glucoside, and palatinose; member of IMA isomaltase family; not required for isomaltose utilization, but Ima2p overexpression allows the ima1 null mutant to grow on isomaltose"
>YOL158C ENB1 SGDID:S000005518, Chr XV from 21311-19491, reverse complement, Verified ORF, "Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment"
>YOL159C YOL159C SGDID:S000005519, Chr XV from 17796-17281, reverse complement, Verified ORF, "Soluble protein of unknown function; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA"
>YOL159C-A YOL159C-A SGDID:S000007627, Chr XV from 15505-15233, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species"
>YOL160W YOL160W SGDID:S000005520, Chr XV from 14313-14654, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YOL161C PAU20 SGDID:S000005521, Chr XV from 11911-11549, reverse complement, Verified ORF, "Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression induced by low temperature and also by anaerobic conditions; induced during alcoholic fermentation"
>YOL162W YOL162W SGDID:S000005522, Chr XV from 10119-10766, Uncharacterized ORF, "Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family"
>YOL163W YOL163W SGDID:S000005523, Chr XV from 9597-10106, Uncharacterized ORF, "Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family"
>YOL164W BDS1 SGDID:S000005524, Chr XV from 6175-8115, Verified ORF, "Bacterially-derived sulfatase required for use of alkyl- and aryl-sulfates as sulfur sources"
>YOL164W-A YOL164W-A SGDID:S000028580, Chr XV from 4130-4312, Uncharacterized ORF, "Putative protein of unknown function; identified by fungal homology and RT-PCR"
>YOL165C AAD15 SGDID:S000005525, Chr XV from 2078-1647, reverse complement, Verified ORF, "Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role"
>YOL166C YOL166C SGDID:S000005526, Chr XV from 1338-1000, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YOL166W-A YOL166W-A SGDID:S000028709, Chr XV from 585-740, Uncharacterized ORF, "Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YOR001W RRP6 SGDID:S000005527, Chr XV from 326832-329033, Verified ORF, "Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10)"
>YOR002W ALG6 SGDID:S000005528, Chr XV from 329417-331051, Verified ORF, "Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease"
>YOR003W YSP3 SGDID:S000005529, Chr XV from 331455-332891, Verified ORF, "Putative precursor to the subtilisin-like protease III"
>YOR004W UTP23 SGDID:S000005530, Chr XV from 333592-334356, Verified ORF, "Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function"
>YOR005C DNL4 SGDID:S000005531, Chr XV from 337343-334509, reverse complement, Verified ORF, "DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth"
>YOR006C TSR3 SGDID:S000005532, Chr XV from 338621-337680, reverse complement, Verified ORF, "Protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus"
>YOR007C SGT2 SGDID:S000005533, Chr XV from 339978-338938, reverse complement, Verified ORF, "Glutamine-rich cytoplasmic protein that serves as a scaffold for binding Get4/5p and other proteins required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; has similarity to human cochaperone SGT"
>YOR008C SLG1 SGDID:S000005534, Chr XV from 342414-341278, reverse complement, Verified ORF, "Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway involved in maintenance of cell wall integrity; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response"
>YOR008C-A YOR008C-A SGDID:S000006431, Chr XV from 343081-342857, reverse complement, Uncharacterized ORF, "Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres"
>YOR008W-B YOR008W-B SGDID:S000007628, Chr XV from 343929-344030, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YOR009W TIR4 SGDID:S000005535, Chr XV from 344335-345798, Verified ORF, "Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock"
>YOR010C TIR2 SGDID:S000005536, Chr XV from 346950-346195, reverse complement, Verified ORF, "Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis"
>YOR011W AUS1 SGDID:S000005537, Chr XV from 349679-353863, Verified ORF, "Transporter of the ATP-binding cassette family, involved in uptake of sterols and anaerobic growth"
>YOR011W-A YOR011W-A SGDID:S000028581, Chr XV from 355652-355858, Uncharacterized ORF, "Putative protein of unknown function"
>YOR012W YOR012W SGDID:S000005538, Chr XV from 356543-356956, Uncharacterized ORF, "Putative protein of unknown function"
>YOR013W IRC11 SGDID:S000005539, Chr XV from 356751-357221, Dubious ORF, "Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci"
>YOR014W RTS1 SGDID:S000005540, Chr XV from 357674-359947, Verified ORF, "B-type regulatory subunit of protein phosphatase 2A (PP2A); homolog of the mammalian B' subunit of PP2A"
>YOR015W YOR015W SGDID:S000005541, Chr XV from 359993-360352, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YOR016C ERP4 SGDID:S000005542, Chr XV from 361084-360461, reverse complement, Verified ORF, "Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport"
>YOR017W PET127 SGDID:S000005543, Chr XV from 361412-363814, Verified ORF, "Protein with a role in 5'-end processing of mitochondrial RNAs, located in the mitochondrial membrane"
>YOR018W ROD1 SGDID:S000005544, Chr XV from 364369-366882, Verified ORF, "Membrane protein that binds the ubiquitin ligase Rsp5p via its 2 PY motifs; overexpression confers resistance to the GST substrate o-dinitrobenzene,zinc, and calcium; proposed to regulate the endocytosis of plasma membrane proteins"
>YOR019W YOR019W SGDID:S000005545, Chr XV from 368127-370319, Verified ORF, "Protein of unknown function that may interact with ribosomes, based on co-purification experiments"
>YOR020C HSP10 SGDID:S000005546, Chr XV from 370844-370524, reverse complement, Verified ORF, "Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES"
>YOR020W-A YOR020W-A SGDID:S000028526, Chr XV from 371685-371957, Uncharacterized ORF, "Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YOR021C YOR021C SGDID:S000005547, Chr XV from 373439-372798, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; YOR021C is not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism"
>YOR022C YOR022C SGDID:S000005548, Chr XV from 375857-373710, reverse complement, Uncharacterized ORF, "Protein with similarity to bovine phospholipase A1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YOR023C AHC1 SGDID:S000005549, Chr XV from 377712-376012, reverse complement, Verified ORF, "Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex"
>YOR024W YOR024W SGDID:S000005550, Chr XV from 377847-378170, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YOR025W HST3 SGDID:S000005551, Chr XV from 378219-379562, Verified ORF, "Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism"
>YOR026W BUB3 SGDID:S000005552, Chr XV from 379781-380806, Verified ORF, "Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p"
>YOR027W STI1 SGDID:S000005553, Chr XV from 381053-382822, Verified ORF, "Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop"
>YOR028C CIN5 SGDID:S000005554, Chr XV from 384420-383533, reverse complement, Verified ORF, "Basic leucine zipper (bZIP) transcription factor of the yAP-1 family, mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions"
>YOR029W YOR029W SGDID:S000005555, Chr XV from 384600-384935, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YOR030W DFG16 SGDID:S000005556, Chr XV from 386825-388684, Verified ORF, "Probable multiple transmembrane protein, involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; required for accumulation of processed Rim101p"
>YOR031W CRS5 SGDID:S000005557, Chr XV from 389213-389422, Verified ORF, "Copper-binding metallothionein, required for wild-type copper resistance"
>YOR032C HMS1 SGDID:S000005558, Chr XV from 391075-389771, reverse complement, Verified ORF, "Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant"
>YOR032W-A YOR032W-A SGDID:S000028710, Chr XV from 392176-392376, Uncharacterized ORF, "Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YOR033C EXO1 SGDID:S000005559, Chr XV from 394524-392416, reverse complement, Verified ORF, "5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains"
>YOR034C AKR2 SGDID:S000005560, Chr XV from 397086-394837, reverse complement, Verified ORF, "Ankyrin repeat-containing protein similar to Akr1p; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p"
>YOR034C-A YOR034C-A SGDID:S000028856, Chr XV from 397668-397426, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by expression profiling and mass spectrometry"
>YOR035C SHE4 SGDID:S000005561, Chr XV from 400104-397735, reverse complement, Verified ORF, "Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization"
>YOR036W PEP12 SGDID:S000005562, Chr XV from 400348-401214, Verified ORF, "Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin"
>YOR037W CYC2 SGDID:S000005563, Chr XV from 401555-402655, Verified ORF, "Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)"
>YOR038C HIR2 SGDID:S000005564, Chr XV from 405388-402761, reverse complement, Verified ORF, "Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p"
>YOR039W CKB2 SGDID:S000005565, Chr XV from 405768-406544, Verified ORF, "Beta' regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB1, the many substrates include transcription factors and all RNA polymerases"
>YOR040W GLO4 SGDID:S000005566, Chr XV from 407064-407921, Verified ORF, "Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate"
>YOR041C YOR041C SGDID:S000005567, Chr XV from 408789-408358, reverse complement, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the uncharacterized gene CUE5; deletion in cyr1 mutant results in loss of stress resistance"
>YOR042W CUE5 SGDID:S000005568, Chr XV from 408425-409660, Verified ORF, "Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern"
>YOR043W WHI2 SGDID:S000005569, Chr XV from 410870-412330, Verified ORF, "Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression"
>YOR044W IRC23 SGDID:S000005570, Chr XV from 413007-413480, Verified ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci"
>YOR045W TOM6 SGDID:S000005571, Chr XV from 413852-414037, Verified ORF, "Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex"
>YOR046C DBP5 SGDID:S000005572, Chr XV from 415907-414459, reverse complement, Verified ORF, "Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family involved in mRNA export from the nucleus; involved in translation termination"
>YOR047C STD1 SGDID:S000005573, Chr XV from 417681-416347, reverse complement, Verified ORF, "Protein involved in control of glucose-regulated gene expression; interacts with protein kinase Snf1p, glucose sensors Snf3p and Rgt2p, and TATA-binding protein Spt15p; acts as a regulator of the transcription factor Rgt1p"
>YOR048C RAT1 SGDID:S000005574, Chr XV from 421650-418630, reverse complement, Verified ORF, "Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination"
>YOR049C RSB1 SGDID:S000005575, Chr XV from 423732-422668, reverse complement, Verified ORF, "Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane"
>YOR050C YOR050C SGDID:S000005576, Chr XV from 424617-424270, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable"
>YOR051C ETT1 SGDID:S000005577, Chr XV from 426084-424846, reverse complement, Verified ORF, "Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough"
>YOR052C YOR052C SGDID:S000005578, Chr XV from 427224-426772, reverse complement, Verified ORF, "Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid"
>YOR053W YOR053W SGDID:S000005579, Chr XV from 427817-428158, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C"
>YOR054C VHS3 SGDID:S000005580, Chr XV from 429857-427833, reverse complement, Verified ORF, "Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis"
>YOR055W YOR055W SGDID:S000005581, Chr XV from 429478-429912, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YOR056C NOB1 SGDID:S000005582, Chr XV from 431626-430247, reverse complement, Verified ORF, "Essential nuclear protein involved in proteasome maturation and synthesis of 40S ribosomal subunits; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA"
>YOR057W SGT1 SGDID:S000005583, Chr XV from 432186-433373, Verified ORF, "Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes"
>YOR058C ASE1 SGDID:S000005584, Chr XV from 436345-433688, reverse complement, Verified ORF, "Mitotic spindle midzone localized microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate"
>YOR059C YOR059C SGDID:S000005585, Chr XV from 440258-438906, reverse complement, Uncharacterized ORF, "Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor RPN4"
>YOR060C YOR060C SGDID:S000005586, Chr XV from 441163-440390, reverse complement, Uncharacterized ORF, "Protein of unknown function required for cell viability; deletion mutant harbors aberrant mitochondria"
>YOR061W CKA2 SGDID:S000005587, Chr XV from 441534-442553, Verified ORF, "Alpha' catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases"
>YOR062C YOR062C SGDID:S000005588, Chr XV from 443531-442725, reverse complement, Uncharacterized ORF, "Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS"
>YOR063W RPL3 SGDID:S000005589, Chr XV from 444686-445849, Verified ORF, "Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus"
>YOR064C YNG1 SGDID:S000005590, Chr XV from 446738-446079, reverse complement, Verified ORF, "Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1"
>YOR065W CYT1 SGDID:S000005591, Chr XV from 447439-448368, Verified ORF, "Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex"
>YOR066W MSA1 SGDID:S000005592, Chr XV from 449436-451325, Verified ORF, "Activator of G1-specific transcription factors, MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation"
>YOR067C ALG8 SGDID:S000005593, Chr XV from 453462-451729, reverse complement, Verified ORF, "Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p"
>YOR068C VAM10 SGDID:S000005594, Chr XV from 454213-453869, reverse complement, Verified ORF, "Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering"
>YOR069W VPS5 SGDID:S000005595, Chr XV from 453768-455795, Verified ORF, "Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p"
>YOR070C GYP1 SGDID:S000005596, Chr XV from 457820-455907, reverse complement, Verified ORF, "Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion"
>YOR071C NRT1 SGDID:S000005597, Chr XV from 461276-459480, reverse complement, Verified ORF, "High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity"
>YOR072W YOR072W SGDID:S000005598, Chr XV from 461502-461816, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive"
>YOR072W-A YOR072W-A SGDID:S000028582, Chr XV from 461791-462039, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR"
>YOR072W-B YOR072W-B SGDID:S000028516, Chr XV from 464469-464630, Uncharacterized ORF, "Putative protein of unknown function; identified by expression profiling and mass spectrometry"
>YOR073W SGO1 SGDID:S000005599, Chr XV from 464771-466543, Verified ORF, "Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability"
>YOR073W-A YOR073W-A SGDID:S000028583, Chr XV from 467390-467623, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CDC21/YOR074C; identified by RT-PCR"
>YOR074C CDC21 SGDID:S000005600, Chr XV from 467589-466675, reverse complement, Verified ORF, "Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S"
>YOR075W UFE1 SGDID:S000005601, Chr XV from 468212-469252, Verified ORF, "t-SNARE required for retrograde vesicular traffic and homotypic ER membrane fusion; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER"
>YOR076C SKI7 SGDID:S000005602, Chr XV from 471620-469377, reverse complement, Verified ORF, "Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype"
>YOR077W RTS2 SGDID:S000005603, Chr XV from 471899-472597, Verified ORF, "Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication"
>YOR078W BUD21 SGDID:S000005604, Chr XV from 472725-473369, Verified ORF, "Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern"
>YOR079C ATX2 SGDID:S000005605, Chr XV from 474416-473475, reverse complement, Verified ORF, "Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation"
>YOR080W DIA2 SGDID:S000005606, Chr XV from 474594-476792, Verified ORF, "Origin-binding F-box protein that forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication, involved in invasive and pseudohyphal growth"
>YOR081C TGL5 SGDID:S000005607, Chr XV from 479188-476939, reverse complement, Verified ORF, "Bifunction enzyme with triacylglycerol lipase and lysophosphatidic acid acyltransferase activity; involved in triacylglycerol mobilization; localizes to lipid particles; potential Cdc28p substrate"
>YOR082C YOR082C SGDID:S000005608, Chr XV from 479637-479296, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W"
>YOR083W WHI5 SGDID:S000005609, Chr XV from 479533-480420, Verified ORF, "Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1"
>YOR084W LPX1 SGDID:S000005610, Chr XV from 480587-481750, Verified ORF, "Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction"
>YOR085W OST3 SGDID:S000005611, Chr XV from 482033-483085, Verified ORF, "Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins"
>YOR086C TCB1 SGDID:S000005612, Chr XV from 486779-483219, reverse complement, Verified ORF, "Lipid-binding protein containing three calcium and lipid binding domains; non-tagged protein localizes to mitochondria and GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interact"
>YOR087W YVC1 SGDID:S000005613, Chr XV from 487707-489734, Verified ORF, "Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock"
>YOR089C VPS21 SGDID:S000005615, Chr XV from 490828-490196, reverse complement, Verified ORF, "Rab family GTPase required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog"
>YOR090C PTC5 SGDID:S000005616, Chr XV from 492841-491123, reverse complement, Verified ORF, "Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p"
>YOR091W TMA46 SGDID:S000005617, Chr XV from 493433-494470, Verified ORF, "Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p"
>YOR092W ECM3 SGDID:S000005618, Chr XV from 495127-496968, Verified ORF, "Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation"
>YOR093C YOR093C SGDID:S000005619, Chr XV from 502452-497506, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents"
>YOR094W ARF3 SGDID:S000005620, Chr XV from 502795-503346, Verified ORF, "Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity"
>YOR095C RKI1 SGDID:S000005621, Chr XV from 504328-503552, reverse complement, Verified ORF, "Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis"
>YOR096W RPS7A SGDID:S000005622, Chr XV from 505794-505937,506339-506767, Verified ORF, "Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins"
>YOR097C YOR097C SGDID:S000005623, Chr XV from 507505-506978, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene"
>YOR098C NUP1 SGDID:S000005624, Chr XV from 511178-507948, reverse complement, Verified ORF, "Nuclear pore complex (NPC) subunit, involved in protein import/export and in export of RNAs, possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; potential Cdc28p substrate"
>YOR099W KTR1 SGDID:S000005625, Chr XV from 511825-513006, Verified ORF, "Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family"
>YOR100C CRC1 SGDID:S000005626, Chr XV from 514278-513295, reverse complement, Verified ORF, "Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation"
>YOR101W RAS1 SGDID:S000005627, Chr XV from 515244-516173, Verified ORF, "GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes"
>YOR102W YOR102W SGDID:S000005628, Chr XV from 516423-516773, Dubious ORF, "Dubious open reading frame, unlikely to encode a functional protein; extensively overlaps essential OST2 gene encoding a subunit of the ER lumen oligosaccharyltransferase complex"
>YOR103C OST2 SGDID:S000005629, Chr XV from 516841-516449, reverse complement, Verified ORF, "Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins"
>YOR104W PIN2 SGDID:S000005630, Chr XV from 517642-518490, Verified ORF, "Protein that induces appearance of [PIN+] prion when overproduced; predicted to be palmitoylated"
>YOR105W YOR105W SGDID:S000005631, Chr XV from 518195-518521, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YOR106W VAM3 SGDID:S000005632, Chr XV from 519121-519972, Verified ORF, "Syntaxin-related protein required for vacuolar assembly; functions with Vam7p in vacuolar protein trafficking; multispecificity vacuolar t-SNARE that mediates docking/fusion of multiple distinct late transport intermediates with the vacuole"
>YOR107W RGS2 SGDID:S000005633, Chr XV from 521353-522282, Verified ORF, "Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p"
>YOR108C-A YOR108C-A SGDID:S000028711, Chr XV from 524814-524605, reverse complement, Dubious ORF, "Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YOR108W LEU9 SGDID:S000005634, Chr XV from 523027-524841, Verified ORF, "Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant"
>YOR109W INP53 SGDID:S000005635, Chr XV from 525278-528601, Verified ORF, "Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains"
>YOR110W TFC7 SGDID:S000005636, Chr XV from 528941-530248, Verified ORF, "One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes"
>YOR111W YOR111W SGDID:S000005637, Chr XV from 530429-531127, Uncharacterized ORF, "Putative protein of unknown function"
>YOR112W CEX1 SGDID:S000005638, Chr XV from 531508-533793, Verified ORF, "Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p"
>YOR113W AZF1 SGDID:S000005639, Chr XV from 534075-536819, Verified ORF, "Zinc-finger transcription factor, involved in induction of CLN3 transcription in response to glucose; genetic and physical interactions indicate a possible role in mitochondrial transcription or genome maintenance"
>YOR114W YOR114W SGDID:S000005640, Chr XV from 537570-538454, Uncharacterized ORF, "Putative protein of unknown function; null mutant is viable"
>YOR115C TRS33 SGDID:S000005641, Chr XV from 539465-538659, reverse complement, Verified ORF, "One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic"
>YOR116C RPO31 SGDID:S000005642, Chr XV from 544145-539763, reverse complement, Verified ORF, "RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21"
>YOR117W RPT5 SGDID:S000005643, Chr XV from 545029-546333, Verified ORF, "One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1"
>YOR118W RTC5 SGDID:S000005644, Chr XV from 546857-548560, Verified ORF, "Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity"
>YOR119C RIO1 SGDID:S000005645, Chr XV from 550246-548792, reverse complement, Verified ORF, "Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA"
>YOR120W GCY1 SGDID:S000005646, Chr XV from 551114-552052, Verified ORF, "Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family"
>YOR121C YOR121C SGDID:S000005647, Chr XV from 552103-551798, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W"
>YOR122C PFY1 SGDID:S000005648, Chr XV from 552665-552298,552887-552875, reverse complement, Verified ORF, "Profilin, binds actin, phosphatidylinositol 4,5-bisphosphate, and polyproline regions; involved in cytoskeleton organization; required for normal timing of actin polymerization in response to thermal stress"
>YOR123C LEO1 SGDID:S000005649, Chr XV from 554570-553176, reverse complement, Verified ORF, "Component of the Paf1 complex, which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition"
>YOR124C UBP2 SGDID:S000005650, Chr XV from 558642-554824, reverse complement, Verified ORF, "Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; interacts with Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity"
>YOR125C CAT5 SGDID:S000005651, Chr XV from 559731-559030, reverse complement, Verified ORF, "Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation"
>YOR126C IAH1 SGDID:S000005652, Chr XV from 560677-559961, reverse complement, Verified ORF, "Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing"
>YOR127W RGA1 SGDID:S000005653, Chr XV from 561170-564193, Verified ORF, "GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth"
>YOR128C ADE2 SGDID:S000005654, Chr XV from 566191-564476, reverse complement, Verified ORF, "Phosphoribosylaminoimidazole carboxylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine"
>YOR129C AFI1 SGDID:S000005655, Chr XV from 569558-566877, reverse complement, Verified ORF, "Arf3p polarization-specific docking factor, required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p"
>YOR130C ORT1 SGDID:S000005656, Chr XV from 570807-569929, reverse complement, Verified ORF, "Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome"
>YOR131C YOR131C SGDID:S000005657, Chr XV from 572838-572182, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; non-essential gene; overexpression causes a cell cycle delay or arrest"
>YOR132W VPS17 SGDID:S000005658, Chr XV from 573175-574830, Verified ORF, "Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation"
>YOR133W EFT1 SGDID:S000005659, Chr XV from 575098-577626, Verified ORF, "Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin"
>YOR134W BAG7 SGDID:S000005660, Chr XV from 578564-579793, Verified ORF, "Rho GTPase activating protein (RhoGAP), stimulates the intrinsic GTPase activity of Rho1p, which plays a role in actin cytoskeleton organization and control of cell wall synthesis; structurally and functionally related to Sac7p"
>YOR135C IRC14 SGDID:S000005661, Chr XV from 580500-580159, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR136W; null mutant displays increased levels of spontaneous Rad52 foci"
>YOR136W IDH2 SGDID:S000005662, Chr XV from 580250-581359, Verified ORF, "Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated"
>YOR137C SIA1 SGDID:S000005663, Chr XV from 583681-581813, reverse complement, Verified ORF, "Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose"
>YOR138C RUP1 SGDID:S000005664, Chr XV from 586324-584309, reverse complement, Verified ORF, "Protein involved in regulation of Rsp5p, which is an essential HECT ubiquitin ligase; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain"
>YOR139C YOR139C SGDID:S000005665, Chr XV from 587342-586950, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SFL1/YOR140W"
>YOR140W SFL1 SGDID:S000005666, Chr XV from 586981-589281, Verified ORF, "Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p"
>YOR141C ARP8 SGDID:S000005667, Chr XV from 592587-589942, reverse complement, Verified ORF, "Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity"
>YOR142W LSC1 SGDID:S000005668, Chr XV from 593057-594046, Verified ORF, "Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated"
>YOR142W-A YOR142W-A SGDID:S000007351, Chr XV from 595112-596434, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YOR142W-B YOR142W-B SGDID:S000007352, Chr XV from 595112-596416,596418-600380, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YOR143C THI80 SGDID:S000005669, Chr XV from 602342-601383, reverse complement, Verified ORF, "Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate)"
>YOR144C ELG1 SGDID:S000005670, Chr XV from 605092-602717, reverse complement, Verified ORF, "Protein required for S phase progression and telomere homeostasis, forms an alternative replication factor C complex important for DNA replication and genome integrity; involved in homologous recombination-mediated DNA repair"
>YOR145C PNO1 SGDID:S000005671, Chr XV from 606171-605347, reverse complement, Verified ORF, "Essential nucleolar protein required for pre-18S rRNA processing, interacts with Dim1p, an 18S rRNA dimethyltransferase, and also with Nob1p, which is involved in proteasome biogenesis; contains a KH domain"
>YOR146W YOR146W SGDID:S000005672, Chr XV from 605873-606178, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C"
>YOR147W MDM32 SGDID:S000005673, Chr XV from 606607-608475, Verified ORF, "Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34"
>YOR148C SPP2 SGDID:S000005674, Chr XV from 609197-608640, reverse complement, Verified ORF, "Essential protein that promotes the first step of splicing and is required for the final stages of spliceosome maturation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction"
>YOR149C SMP3 SGDID:S000005675, Chr XV from 611388-609838, reverse complement, Verified ORF, "Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure"
>YOR150W MRPL23 SGDID:S000005676, Chr XV from 611999-612490, Verified ORF, "Mitochondrial ribosomal protein of the large subunit"
>YOR151C RPB2 SGDID:S000005677, Chr XV from 616671-612997, reverse complement, Verified ORF, "RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit"
>YOR152C YOR152C SGDID:S000005678, Chr XV from 618288-617518, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene"
>YOR153W PDR5 SGDID:S000005679, Chr XV from 619840-624375, Verified ORF, "Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth"
>YOR154W SLP1 SGDID:S000005680, Chr XV from 624729-626492, Uncharacterized ORF, "Integral membrane protein of unknown function; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins"
>YOR155C ISN1 SGDID:S000005681, Chr XV from 627980-626628, reverse complement, Verified ORF, "Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms"
>YOR156C NFI1 SGDID:S000005682, Chr XV from 630540-628360, reverse complement, Verified ORF, "SUMO ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins; involved in maintenance of proper telomere length"
>YOR157C PUP1 SGDID:S000005683, Chr XV from 631751-630966, reverse complement, Verified ORF, "Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z"
>YOR158W PET123 SGDID:S000005684, Chr XV from 632164-633120, Verified ORF, "Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator"
>YOR159C SME1 SGDID:S000005685, Chr XV from 633566-633282, reverse complement, Verified ORF, "Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E"
>YOR160W MTR10 SGDID:S000005686, Chr XV from 633839-636757, Verified ORF, "Nuclear import receptor, mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs"
>YOR161C PNS1 SGDID:S000005687, Chr XV from 638558-636939, reverse complement, Verified ORF, "Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport"
>YOR161C-C YOR161C-C SGDID:S000028712, Chr XV from 639267-639121, reverse complement, Uncharacterized ORF, "Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YOR161W-A YOR161W-A SGDID:S000028713, Chr XV from 637574-637654, Dubious ORF, "Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YOR161W-B YOR161W-B SGDID:S000028714, Chr XV from 637975-638235, Dubious ORF, "Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YOR162C YRR1 SGDID:S000005688, Chr XV from 641992-639560, reverse complement, Verified ORF, "Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes"
>YOR163W DDP1 SGDID:S000005689, Chr XV from 642741-643307, Verified ORF, "Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; has high specificity for diadenosine hexa- and pentaphosphates; member of the MutT family of nucleotide hydrolases"
>YOR164C GET4 SGDID:S000005690, Chr XV from 644332-643394, reverse complement, Verified ORF, "Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20"
>YOR165W SEY1 SGDID:S000005691, Chr XV from 644566-646896, Verified ORF, "GTPase with a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; possible functional ortholog of mammalian atlastins, defects in which cause a form of hereditary spastic paraplegia; homolog of Arabidopsis RHD3"
>YOR166C SWT1 SGDID:S000005692, Chr XV from 648502-647126, reverse complement, Verified ORF, "RNA endoribonuclease involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain"
>YOR167C RPS28A SGDID:S000005693, Chr XV from 649007-648804, reverse complement, Verified ORF, "Protein component of the small (40S) ribosomal subunit; nearly identical to Rps28Bp and has similarity to rat S28 ribosomal protein"
>YOR168W GLN4 SGDID:S000005694, Chr XV from 649303-651732, Verified ORF, "Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions"
>YOR169C YOR169C SGDID:S000005695, Chr XV from 651840-651376, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GLN4/YOR168W"
>YOR170W YOR170W SGDID:S000005696, Chr XV from 651858-652163, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4"
>YOR171C LCB4 SGDID:S000005697, Chr XV from 653884-652010, reverse complement, Verified ORF, "Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes"
>YOR172W YRM1 SGDID:S000005698, Chr XV from 654210-656570, Verified ORF, "Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes"
>YOR173W DCS2 SGDID:S000005699, Chr XV from 657264-658325, Verified ORF, "Non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance"
>YOR174W MED4 SGDID:S000005700, Chr XV from 658747-659601, Verified ORF, "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation"
>YOR175C ALE1 SGDID:S000005701, Chr XV from 661674-659815, reverse complement, Verified ORF, "Broad-specificity lysophospholipid acyltransferase, part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids"
>YOR176W HEM15 SGDID:S000005702, Chr XV from 662401-663582, Verified ORF, "Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway"
>YOR177C MPC54 SGDID:S000005703, Chr XV from 667179-665785, reverse complement, Verified ORF, "Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate"
>YOR178C GAC1 SGDID:S000005704, Chr XV from 670241-667860, reverse complement, Verified ORF, "Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock"
>YOR179C SYC1 SGDID:S000005705, Chr XV from 672411-671845, reverse complement, Verified ORF, "Subunit of the APT subcomplex of cleavage and polyadenylation factor, may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs"
>YOR180C DCI1 SGDID:S000005706, Chr XV from 675167-674352, reverse complement, Verified ORF, "Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed"
>YOR181W LAS17 SGDID:S000005707, Chr XV from 675939-677840, Verified ORF, "Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)"
>YOR182C RPS30B SGDID:S000005708, Chr XV from 678379-678191,678793-678791, reverse complement, Verified ORF, "Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Ap and has similarity to rat S30 ribosomal protein"
>YOR183W FYV12 SGDID:S000005709, Chr XV from 678872-679261, Uncharacterized ORF, "Protein of unknown function, required for survival upon exposure to K1 killer toxin"
>YOR184W SER1 SGDID:S000005710, Chr XV from 679357-680544, Verified ORF, "3-phosphoserine aminotransferase, catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p"
>YOR185C GSP2 SGDID:S000005711, Chr XV from 682106-681444, reverse complement, Verified ORF, "GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability"
>YOR186C-A YOR186C-A SGDID:S000028715, Chr XV from 683538-683329, reverse complement, Dubious ORF, "Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YOR186W YOR186W SGDID:S000005712, Chr XV from 683111-683545, Uncharacterized ORF, "Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent"
>YOR187W TUF1 SGDID:S000005713, Chr XV from 684030-685343, Verified ORF, "Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans"
>YOR188W MSB1 SGDID:S000005714, Chr XV from 685767-689180, Verified ORF, "Protein involved in positive regulation of both 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway, potential Cdc28p substrate; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4"
>YOR189W IES4 SGDID:S000005715, Chr XV from 689624-689974, Verified ORF, "Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses"
>YOR190W SPR1 SGDID:S000005716, Chr XV from 690695-692032, Verified ORF, "Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance"
>YOR191W ULS1 SGDID:S000005717, Chr XV from 692475-697334, Verified ORF, "RING finger protein involved in proteolytic control of sumoylated substrates; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching"
>YOR192C THI72 SGDID:S000005718, Chr XV from 700567-698768, reverse complement, Verified ORF, "Transporter of thiamine or related compound; shares sequence similarity with Thi7p"
>YOR192C-A YOR192C-A SGDID:S000007353, Chr XV from 709732-708416, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YOR192C-B YOR192C-B SGDID:S000007354, Chr XV from 708438-704419,709732-708440, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YOR192C-C YOR192C-C SGDID:S000028857, Chr XV from 704224-703988, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by expression profiling and mass spectrometry"
>YOR193W PEX27 SGDID:S000005719, Chr XV from 710446-711576, Verified ORF, "Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p"
>YOR194C TOA1 SGDID:S000005720, Chr XV from 712543-711683, reverse complement, Verified ORF, "TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIA"
>YOR195W SLK19 SGDID:S000005721, Chr XV from 712866-715331, Verified ORF, "Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate"
>YOR196C LIP5 SGDID:S000005722, Chr XV from 716837-715593, reverse complement, Verified ORF, "Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase"
>YOR197W MCA1 SGDID:S000005723, Chr XV from 717086-718384, Verified ORF, "Putative cysteine protease similar to mammalian caspases; involved in regulation of apoptosis upon hydrogen peroxide treatment; proposed to be involved in cell cycle progression"
>YOR198C BFR1 SGDID:S000005724, Chr XV from 720065-718653, reverse complement, Verified ORF, "Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity"
>YOR199W YOR199W SGDID:S000005725, Chr XV from 720181-720510, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YOR200W YOR200W SGDID:S000005726, Chr XV from 720417-720815, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRM1/YOR201c"
>YOR201C MRM1 SGDID:S000005727, Chr XV from 721708-720470, reverse complement, Verified ORF, "Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA"
>YOR202W HIS3 SGDID:S000005728, Chr XV from 721946-722608, Verified ORF, "Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p"
>YOR203W YOR203W SGDID:S000005729, Chr XV from 722565-722918, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps 5' end of essential DED1 gene required for translation initiation"
>YOR204W DED1 SGDID:S000005730, Chr XV from 722911-724725, Verified ORF, "ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility"
>YOR205C GEP3 SGDID:S000005731, Chr XV from 727234-725564, reverse complement, Verified ORF, "Protein of unknown function; null mutant is defective in respiration and interacts synthetically with prohibitin (phb1); the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies"
>YOR206W NOC2 SGDID:S000005732, Chr XV from 727512-729644, Verified ORF, "Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors"
>YOR207C RET1 SGDID:S000005733, Chr XV from 733457-730008, reverse complement, Verified ORF, "Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs"
>YOR208W PTP2 SGDID:S000005734, Chr XV from 733925-736177, Verified ORF, "Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus"
>YOR209C NPT1 SGDID:S000005735, Chr XV from 737726-736437, reverse complement, Verified ORF, "Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus"
>YOR210W RPB10 SGDID:S000005736, Chr XV from 738320-738532, Verified ORF, "RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III"
>YOR211C MGM1 SGDID:S000005737, Chr XV from 741569-738924, reverse complement, Verified ORF, "Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mt morphology and genome maintenance; exists as long and short form with different distributions; homolog of human OPA1 involved in autosomal dominant optic atrophy"
>YOR212W STE4 SGDID:S000005738, Chr XV from 742910-744181, Verified ORF, "G protein beta subunit, forms a dimer with Ste18p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling; may recruit Rho1p to the polarized growth site during mating; contains WD40 repeats"
>YOR213C SAS5 SGDID:S000005739, Chr XV from 745281-744535, reverse complement, Verified ORF, "Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which  acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity"
>YOR214C YOR214C SGDID:S000005740, Chr XV from 746303-745593, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; YOR214C is not an essential gene"
>YOR215C AIM41 SGDID:S000005741, Chr XV from 747282-746725, reverse complement, Verified ORF, "Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss"
>YOR216C RUD3 SGDID:S000005742, Chr XV from 748979-747525, reverse complement, Verified ORF, "Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1"
>YOR217W RFC1 SGDID:S000005743, Chr XV from 749301-751886, Verified ORF, "Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon"
>YOR218C YOR218C SGDID:S000005744, Chr XV from 751895-751476, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W"
>YOR219C STE13 SGDID:S000005745, Chr XV from 755009-752214, reverse complement, Verified ORF, "Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor"
>YOR220W RCN2 SGDID:S000005746, Chr XV from 755328-756125, Uncharacterized ORF, "Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; phosphorylated in response to alpha factor"
>YOR221C MCT1 SGDID:S000005747, Chr XV from 757558-756476, reverse complement, Verified ORF, "Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling"
>YOR222W ODC2 SGDID:S000005748, Chr XV from 758330-759253, Verified ORF, "Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism"
>YOR223W YOR223W SGDID:S000005749, Chr XV from 759782-760660, Uncharacterized ORF, "Putative protein of unknown function"
>YOR224C RPB8 SGDID:S000005750, Chr XV from 761265-760825, reverse complement, Verified ORF, "RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III"
>YOR225W YOR225W SGDID:S000005751, Chr XV from 761392-761721, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YOR226C ISU2 SGDID:S000005752, Chr XV from 762084-761614, reverse complement, Verified ORF, "Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable"
>YOR227W HER1 SGDID:S000005753, Chr XV from 762825-766565, Verified ORF, "Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments"
>YOR228C YOR228C SGDID:S000005754, Chr XV from 767777-766869, reverse complement, Verified ORF, "Protein of unknown function, localized to the mitochondrial outer membrane"
>YOR229W WTM2 SGDID:S000005755, Chr XV from 768409-769812, Verified ORF, "Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats"
>YOR230W WTM1 SGDID:S000005756, Chr XV from 770800-772113, Verified ORF, "Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats"
>YOR231C-A YOR231C-A SGDID:S000028716, Chr XV from 773363-773163, reverse complement, Dubious ORF, "Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YOR231W MKK1 SGDID:S000005757, Chr XV from 772601-774127, Verified ORF, "Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p"
>YOR232W MGE1 SGDID:S000005758, Chr XV from 774573-775259, Verified ORF, "Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE"
>YOR233W KIN4 SGDID:S000005759, Chr XV from 775846-778248, Verified ORF, "Serine/threonine protein kinase that inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck"
>YOR234C RPL33B SGDID:S000005760, Chr XV from 778859-778555,779405-779387, reverse complement, Verified ORF, "Ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Ap and has similarity to rat L35a; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable"
>YOR235W IRC13 SGDID:S000005761, Chr XV from 779870-780184, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci"
>YOR236W DFR1 SGDID:S000005762, Chr XV from 780906-781541, Verified ORF, "Dihydrofolate reductase, part of the dTTP biosynthetic pathway, involved in folate metabolism, possibly required for mitochondrial function"
>YOR237W HES1 SGDID:S000005763, Chr XV from 781994-783298, Verified ORF, "Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP)"
>YOR238W YOR238W SGDID:S000005764, Chr XV from 783677-784588, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"
>YOR239W ABP140 SGDID:S000005765, Chr XV from 784857-785687,785689-786744, Verified ORF, "Nonessential protein that binds actin filaments and localizes to actin patches and cables, has similarity to S-adenosylmethionine (AdoMet)-dependent methyltransferases"
>YOR241W MET7 SGDID:S000005767, Chr XV from 786995-788641, Verified ORF, "Folylpolyglutamate synthetase, catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA"
>YOR242C SSP2 SGDID:S000005768, Chr XV from 789857-788742, reverse complement, Verified ORF, "Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis"
>YOR243C PUS7 SGDID:S000005769, Chr XV from 792241-790211, reverse complement, Verified ORF, "Pseudouridine synthase, catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria"
>YOR244W ESA1 SGDID:S000005770, Chr XV from 792531-793868, Verified ORF, "Catalytic subunit of the histone acetyltransferase complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression and transcriptional silencing at the rDNA locus"
>YOR245C DGA1 SGDID:S000005771, Chr XV from 795332-794076, reverse complement, Verified ORF, "Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles"
>YOR246C YOR246C SGDID:S000005772, Chr XV from 796793-795801, reverse complement, Uncharacterized ORF, "Protein with similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts"
>YOR247W SRL1 SGDID:S000005773, Chr XV from 797676-798308, Verified ORF, "Mannoprotein that exhibits a tight association with the cell wall, required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants"
>YOR248W YOR248W SGDID:S000005774, Chr XV from 798013-798315, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YOR249C APC5 SGDID:S000005775, Chr XV from 800731-798674, reverse complement, Verified ORF, "Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition"
>YOR250C CLP1 SGDID:S000005776, Chr XV from 802307-800970, reverse complement, Verified ORF, "Subunit of cleavage factor I (CFI), involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation"
>YOR251C TUM1 SGDID:S000005777, Chr XV from 803464-802550, reverse complement, Verified ORF, "Rhodanese domain sulfur transferase, accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; may be mitochondrially localized"
>YOR252W TMA16 SGDID:S000005778, Chr XV from 803667-804203, Verified ORF, "Protein of unknown function that associates with ribosomes"
>YOR253W NAT5 SGDID:S000005779, Chr XV from 804377-804907, Verified ORF, "Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing"
>YOR254C SEC63 SGDID:S000005780, Chr XV from 807023-805032, reverse complement, Verified ORF, "Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER"
>YOR255W OSW1 SGDID:S000005781, Chr XV from 807271-808107, Verified ORF, "Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p"
>YOR256C TRE2 SGDID:S000005782, Chr XV from 810683-808254, reverse complement, Verified ORF, "Protein that functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; has similarity to transferrin receptors; inviability of null mutant in systematic studies is due to proximity to CDC31"
>YOR257W CDC31 SGDID:S000005783, Chr XV from 811008-811493, Verified ORF, "Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation"
>YOR258W HNT3 SGDID:S000005784, Chr XV from 811671-812324, Verified ORF, "DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia"
>YOR259C RPT4 SGDID:S000005785, Chr XV from 813708-812395, reverse complement, Verified ORF, "One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in degradation of ubiquitinated substrates; contributes preferentially to ERAD; required for spindle pole body duplication; mainly nuclear localization"
>YOR260W GCD1 SGDID:S000005786, Chr XV from 813984-815720, Verified ORF, "Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression"
>YOR261C RPN8 SGDID:S000005787, Chr XV from 816931-815915, reverse complement, Verified ORF, "Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p"
>YOR262W YOR262W SGDID:S000005788, Chr XV from 817292-818335, Verified ORF, "Protein of unknown function required for establishment of sister chromatid cohesion; contains an ATP/GTP binding site motif; similar to YLR243W and is highly conserved across species and homologous to human gene GPN2/ATPBD1B"
>YOR263C YOR263C SGDID:S000005789, Chr XV from 819164-818757, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W"
>YOR264W DSE3 SGDID:S000005790, Chr XV from 818866-820158, Verified ORF, "Daughter cell-specific protein, may help establish daughter fate"
>YOR265W RBL2 SGDID:S000005791, Chr XV from 820454-820774, Verified ORF, "Protein involved in microtubule morphogenesis, required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A"
>YOR266W PNT1 SGDID:S000005792, Chr XV from 821023-822294, Verified ORF, "Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine"
>YOR267C HRK1 SGDID:S000005793, Chr XV from 824867-822588, reverse complement, Verified ORF, "Protein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis"
>YOR268C YOR268C SGDID:S000005794, Chr XV from 825932-825534, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene"
>YOR269W PAC1 SGDID:S000005795, Chr XV from 826385-827869, Verified ORF, "Protein involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; synthetic lethal with bni1; homolog of human LIS1"
>YOR270C VPH1 SGDID:S000005796, Chr XV from 830574-828052, reverse complement, Verified ORF, "Subunit a of vacuolar-ATPase V0 domain, one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes"
>YOR271C FSF1 SGDID:S000005797, Chr XV from 832042-831059, reverse complement, Uncharacterized ORF, "Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis"
>YOR272W YTM1 SGDID:S000005798, Chr XV from 832813-834195, Verified ORF, "Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats"
>YOR273C TPO4 SGDID:S000005799, Chr XV from 836431-834452, reverse complement, Verified ORF, "Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily"
>YOR274W MOD5 SGDID:S000005800, Chr XV from 837674-838960, Verified ORF, "Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase, required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms"
>YOR275C RIM20 SGDID:S000005801, Chr XV from 841069-839084, reverse complement, Verified ORF, "Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation"
>YOR276W CAF20 SGDID:S000005802, Chr XV from 841333-841818, Verified ORF, "Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E"
>YOR277C YOR277C SGDID:S000005803, Chr XV from 841823-841515, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20"
>YOR278W HEM4 SGDID:S000005804, Chr XV from 842817-843644, Verified ORF, "Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria"
>YOR279C RFM1 SGDID:S000005805, Chr XV from 844630-843698, reverse complement, Verified ORF, "DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance"
>YOR280C FSH3 SGDID:S000005806, Chr XV from 845792-844992, reverse complement, Verified ORF, "Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2"
>YOR281C PLP2 SGDID:S000005807, Chr XV from 847129-846269, reverse complement, Verified ORF, "Essential protein that interacts with the CCT (chaperonin containing TCP-1) complex to stimulate actin folding; has similarity to phosducins; null mutant lethality is complemented by mouse phosducin-like protein MgcPhLP"
>YOR282W YOR282W SGDID:S000005808, Chr XV from 847000-847320, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C"
>YOR283W YOR283W SGDID:S000005809, Chr XV from 847453-848145, Uncharacterized ORF, "Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene"
>YOR284W HUA2 SGDID:S000005810, Chr XV from 848478-849209, Verified ORF, "Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly"
>YOR285W RDL1 SGDID:S000005811, Chr XV from 849635-850054, Verified ORF, "Protein of unknown function containing a rhodanese-like domain; localized to the mitochondrial outer membrane"
>YOR286W RDL2 SGDID:S000005812, Chr XV from 850280-850729, Verified ORF, "Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss"
>YOR287C RRP36 SGDID:S000005813, Chr XV from 851839-850937, reverse complement, Verified ORF, "Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit"
>YOR288C MPD1 SGDID:S000005814, Chr XV from 853077-852121, reverse complement, Verified ORF, "Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation"
>YOR289W YOR289W SGDID:S000005815, Chr XV from 853357-854112, Uncharacterized ORF, "Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus"
>YOR290C SNF2 SGDID:S000005816, Chr XV from 860258-855147, reverse complement, Verified ORF, "Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p"
>YOR291W YPK9 SGDID:S000005817, Chr XV from 861175-865593, Verified ORF, "Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome"
>YOR292C YOR292C SGDID:S000005818, Chr XV from 866582-865653, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene"
>YOR293C-A YOR293C-A SGDID:S000028858, Chr XV from 868147-867998, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by expression profiling and mass spectrometry"
>YOR293W RPS10A SGDID:S000005819, Chr XV from 867098-867149,867587-867852, Verified ORF, "Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Bp and has similarity to rat ribosomal protein S10"
>YOR294W RRS1 SGDID:S000005820, Chr XV from 868340-868951, Verified ORF, "Essential protein that binds ribosomal protein L11 and is required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; mouse homolog shows altered expression in Huntington's disease model mice"
>YOR295W UAF30 SGDID:S000005821, Chr XV from 869208-869894, Verified ORF, "Subunit of UAF (upstream activation factor), which is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate"
>YOR296W YOR296W SGDID:S000005822, Chr XV from 870202-874071, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene"
>YOR297C TIM18 SGDID:S000005823, Chr XV from 875321-874743, reverse complement, Verified ORF, "Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex"
>YOR298C-A MBF1 SGDID:S000007253, Chr XV from 877685-877230, reverse complement, Verified ORF, "Transcriptional coactivator that bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations"
>YOR298W MUM3 SGDID:S000005824, Chr XV from 875599-877038, Verified ORF, "Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases"
>YOR299W BUD7 SGDID:S000005825, Chr XV from 878435-880675, Verified ORF, "Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane"
>YOR300W YOR300W SGDID:S000005826, Chr XV from 880575-880883, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7"
>YOR301W RAX1 SGDID:S000005827, Chr XV from 880965-882272, Verified ORF, "Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily"
>YOR302W YOR302W SGDID:S000005828, Chr XV from 882765-882842, Verified ORF, "CPA1 uORF, Arginine attenuator peptide, regulates translation of the CPA1 mRNA"
>YOR303W CPA1 SGDID:S000005829, Chr XV from 882899-884134, Verified ORF, "Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader"
>YOR304C-A YOR304C-A SGDID:S000005830, Chr XV from 888750-888520, reverse complement, Uncharacterized ORF, "Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck"
>YOR304W ISW2 SGDID:S000005831, Chr XV from 884514-887876, Verified ORF, "ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth"
>YOR305W RRG7 SGDID:S000005832, Chr XV from 889022-889750, Verified ORF, "Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene"
>YOR306C MCH5 SGDID:S000005833, Chr XV from 891432-889867, reverse complement, Verified ORF, "Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport"
>YOR307C SLY41 SGDID:S000005834, Chr XV from 894092-892731, reverse complement, Verified ORF, "Protein involved in ER-to-Golgi transport"
>YOR308C SNU66 SGDID:S000005835, Chr XV from 896387-894624, reverse complement, Verified ORF, "Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1"
>YOR309C YOR309C SGDID:S000005836, Chr XV from 897078-896698, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58"
>YOR310C NOP58 SGDID:S000005837, Chr XV from 898360-896825, reverse complement, Verified ORF, "Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA"
>YOR311C DGK1 SGDID:S000005838, Chr XV from 899928-899056, reverse complement, Verified ORF, "Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain"
>YOR312C RPL20B SGDID:S000005839, Chr XV from 900767-900250,901194-901194, reverse complement, Verified ORF, "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Ap and has similarity to rat L18a ribosomal protein"
>YOR313C SPS4 SGDID:S000005840, Chr XV from 902874-901858, reverse complement, Verified ORF, "Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage"
>YOR314W YOR314W SGDID:S000005841, Chr XV from 903043-903372, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YOR314W-A YOR314W-A SGDID:S000007629, Chr XV from 904458-904568, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YOR315W SFG1 SGDID:S000005842, Chr XV from 904760-905800, Verified ORF, "Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate"
>YOR316C COT1 SGDID:S000005843, Chr XV from 907555-906236, reverse complement, Verified ORF, "Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium"
>YOR316C-A YOR316C-A SGDID:S000028584, Chr XV from 907935-907726, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by fungal homology and RT-PCR"
>YOR317W FAA1 SGDID:S000005844, Chr XV from 909343-911445, Verified ORF, "Long chain fatty acyl-CoA synthetase, activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; accounts for most acyl-CoA synthetase activity; localized to lipid particles"
>YOR318C YOR318C SGDID:S000005845, Chr XV from 912085-911784,912436-912433, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo"
>YOR319W HSH49 SGDID:S000005846, Chr XV from 912822-913463, Verified ORF, "U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)"
>YOR320C GNT1 SGDID:S000005847, Chr XV from 915094-913619, reverse complement, Verified ORF, "N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus"
>YOR321W PMT3 SGDID:S000005848, Chr XV from 916030-918291, Verified ORF, "Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; target for new antifungals"
>YOR322C LDB19 SGDID:S000005849, Chr XV from 921062-918606, reverse complement, Verified ORF, "Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; localization changes in response to nutrient levels; null mutant has reduced affinity for alcian blue dye"
>YOR323C PRO2 SGDID:S000005850, Chr XV from 922905-921535, reverse complement, Verified ORF, "Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis"
>YOR324C FRT1 SGDID:S000005851, Chr XV from 925040-923232, reverse complement, Verified ORF, "Tail-anchored ER membrane protein that is a substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation"
>YOR325W YOR325W SGDID:S000005852, Chr XV from 924577-925050, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1"
>YOR326W MYO2 SGDID:S000005853, Chr XV from 925721-930445, Verified ORF, "One of two type V myosin motors (along with MYO4) involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle"
>YOR327C SNC2 SGDID:S000005854, Chr XV from 931081-930734, reverse complement, Verified ORF, "Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins"
>YOR328W PDR10 SGDID:S000005855, Chr XV from 931803-936497, Verified ORF, "ATP-binding cassette (ABC) transporter, multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p"
>YOR329C SCD5 SGDID:S000005856, Chr XV from 939349-936731, reverse complement, Verified ORF, "Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency"
>YOR329W-A YOR329W-A SGDID:S000028585, Chr XV from 939348-939557, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR"
>YOR330C MIP1 SGDID:S000005857, Chr XV from 943385-939621, reverse complement, Verified ORF, "Catalytic subunit of the mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; related to human POLG, which has been associated with mitochondrial diseases"
>YOR331C YOR331C SGDID:S000005858, Chr XV from 944122-943565, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene VMA4/YOR332W"
>YOR332W VMA4 SGDID:S000005859, Chr XV from 943656-944357, Verified ORF, "Subunit E of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane"
>YOR333C YOR333C SGDID:S000005860, Chr XV from 944957-944541, reverse complement, Dubious ORF, "Dubious open reading frame, unlikely to encode a functional protein; overlaps 5' end of MRS2 gene required for respiratory growth"
>YOR334W MRS2 SGDID:S000005861, Chr XV from 944596-946008, Verified ORF, "Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns"
>YOR335C ALA1 SGDID:S000005862, Chr XV from 949109-946233, reverse complement, Verified ORF, "Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog"
>YOR335W-A YOR335W-A SGDID:S000028717, Chr XV from 946568-946648, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ALA1/YOR335C"
>YOR336W KRE5 SGDID:S000005863, Chr XV from 949773-953870, Verified ORF, "Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects"
>YOR337W TEA1 SGDID:S000005864, Chr XV from 954344-956623, Verified ORF, "Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein"
>YOR338W YOR338W SGDID:S000005865, Chr XV from 956898-957989, Uncharacterized ORF, "Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen"
>YOR339C UBC11 SGDID:S000005866, Chr XV from 958832-958362, reverse complement, Verified ORF, "Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2"
>YOR340C RPA43 SGDID:S000005867, Chr XV from 960182-959202, reverse complement, Verified ORF, "RNA polymerase I subunit A43"
>YOR341W RPA190 SGDID:S000005868, Chr XV from 960987-965981, Verified ORF, "RNA polymerase I largest subunit A190"
>YOR342C YOR342C SGDID:S000005869, Chr XV from 967625-966666, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus"
>YOR343C YOR343C SGDID:S000005870, Chr XV from 968474-968148, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YOR343W-A YOR343W-A SGDID:S000007355, Chr XV from 970578-971894, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YOR343W-B YOR343W-B SGDID:S000007356, Chr XV from 970578-971871,971873-975891, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YOR344C TYE7 SGDID:S000005871, Chr XV from 978069-977194, reverse complement, Verified ORF, "Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression"
>YOR345C YOR345C SGDID:S000005872, Chr XV from 982162-981812, reverse complement, Dubious ORF, "Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2"
>YOR346W REV1 SGDID:S000005873, Chr XV from 981828-984785, Verified ORF, "Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA"
>YOR347C PYK2 SGDID:S000005874, Chr XV from 986462-984942, reverse complement, Verified ORF, "Pyruvate kinase that appears to be modulated by phosphorylation; PYK2 transcription is repressed by glucose, and Pyk2p may be active under low glycolytic flux"
>YOR348C PUT4 SGDID:S000005875, Chr XV from 988782-986899, reverse complement, Verified ORF, "Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells"
>YOR349W CIN1 SGDID:S000005876, Chr XV from 989789-992833, Verified ORF, "Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl"
>YOR350C MNE1 SGDID:S000005877, Chr XV from 994855-992864, reverse complement, Verified ORF, "Mitochondrial protein similar to Lucilia illustris mitochondrial cytochrome oxidase"
>YOR351C MEK1 SGDID:S000005878, Chr XV from 996511-995018, reverse complement, Verified ORF, "Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids"
>YOR352W YOR352W SGDID:S000005879, Chr XV from 997213-998244, Uncharacterized ORF, "Putative protein of unknown function; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus"
>YOR353C SOG2 SGDID:S000005880, Chr XV from 1000828-998453, reverse complement, Verified ORF, "Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis"
>YOR354C MSC6 SGDID:S000005881, Chr XV from 1003225-1001147, reverse complement, Verified ORF, "Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YOR355W GDS1 SGDID:S000005882, Chr XV from 1005137-1006705, Verified ORF, "Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YOR356W YOR356W SGDID:S000005883, Chr XV from 1007221-1009116, Verified ORF, "Mitochondrial protein with similarity to flavoprotein-type oxidoreductases; found in a large supramolecular complex with other mitochondrial dehydrogenases"
>YOR357C SNX3 SGDID:S000005884, Chr XV from 1009712-1009224, reverse complement, Verified ORF, "Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p"
>YOR358W HAP5 SGDID:S000005885, Chr XV from 1010161-1010889, Verified ORF, "Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex"
>YOR359W VTS1 SGDID:S000005886, Chr XV from 1011189-1012760, Verified ORF, "Post-transcriptional gene regulator, flap-structured DNA-binding and RNA-binding protein; shows genetic interactions with Vti1p, a v-SNARE involved in cis-Golgi membrane traffic; stimulates Dna2p endonuclease activity; contains a SAM domain"
>YOR360C PDE2 SGDID:S000005887, Chr XV from 1014821-1013241, reverse complement, Verified ORF, "High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon"
>YOR361C PRT1 SGDID:S000005888, Chr XV from 1017652-1015361, reverse complement, Verified ORF, "eIF3b subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes"
>YOR362C PRE10 SGDID:S000005889, Chr XV from 1018746-1017880, reverse complement, Verified ORF, "Alpha 7 subunit of the 20S proteasome"
>YOR363C PIP2 SGDID:S000005890, Chr XV from 1023212-1020222, reverse complement, Verified ORF, "Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes"
>YOR364W YOR364W SGDID:S000005891, Chr XV from 1023371-1023739, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C"
>YOR365C YOR365C SGDID:S000005892, Chr XV from 1025572-1023461, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; YOR365C is not an essential protein"
>YOR366W YOR366W SGDID:S000005893, Chr XV from 1025256-1025609, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C"
>YOR367W SCP1 SGDID:S000005894, Chr XV from 1026007-1026609, Verified ORF, "Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin"
>YOR368W RAD17 SGDID:S000005895, Chr XV from 1026843-1028048, Verified ORF, "Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins"
>YOR369C RPS12 SGDID:S000005896, Chr XV from 1028625-1028194, reverse complement, Verified ORF, "Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12"
>YOR370C MRS6 SGDID:S000005897, Chr XV from 1030994-1029183, reverse complement, Verified ORF, "Rab escort protein, forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); sequence similarity to mammalian choroideraemia gene"
>YOR371C GPB1 SGDID:S000005898, Chr XV from 1034182-1031489, reverse complement, Verified ORF, "Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; promotes ubiquitin-dependent proteolysis of Ira2p; regulated by G-alpha protein Gpa2p; homolog of Gpb2p"
>YOR372C NDD1 SGDID:S000005899, Chr XV from 1036471-1034807, reverse complement, Verified ORF, "Transcriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a set of late-S-phase-specific genes"
>YOR373W NUD1 SGDID:S000005900, Chr XV from 1036834-1039389, Verified ORF, "Component of the spindle pole body outer plaque, required for exit from mitosis"
>YOR374W ALD4 SGDID:S000005901, Chr XV from 1039840-1041399, Verified ORF, "Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed"
>YOR375C GDH1 SGDID:S000005902, Chr XV from 1043042-1041678, reverse complement, Verified ORF, "NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources"
>YOR376W YOR376W SGDID:S000005903, Chr XV from 1043191-1043559, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene."
>YOR376W-A YOR376W-A SGDID:S000028586, Chr XV from 1045196-1045351, Uncharacterized ORF, "Putative protein of unknown function; identified by fungal homology and RT-PCR"
>YOR377W ATF1 SGDID:S000005904, Chr XV from 1046226-1047803, Verified ORF, "Alcohol acetyltransferase with potential roles in lipid and sterol metabolism; responsible for the major part of volatile acetate ester production during fermentation"
>YOR378W YOR378W SGDID:S000005905, Chr XV from 1049511-1051058, Uncharacterized ORF, "Putative paralog of ATR1, but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene"
>YOR379C YOR379C SGDID:S000005906, Chr XV from 1051064-1050726, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR378W"
>YOR380W RDR1 SGDID:S000005907, Chr XV from 1051290-1052930, Verified ORF, "Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins"
>YOR381W FRE3 SGDID:S000005908, Chr XV from 1055545-1057680, Verified ORF, "Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels"
>YOR381W-A YOR381W-A SGDID:S000028587, Chr XV from 1058423-1058590, Uncharacterized ORF, "Putative protein of unknown function; identified by fungal homology and RT-PCR"
>YOR382W FIT2 SGDID:S000005909, Chr XV from 1059531-1059992, Verified ORF, "Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall"
>YOR383C FIT3 SGDID:S000005910, Chr XV from 1061055-1060441, reverse complement, Verified ORF, "Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall"
>YOR384W FRE5 SGDID:S000005911, Chr XV from 1061564-1063648, Verified ORF, "Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YOR385W YOR385W SGDID:S000005912, Chr XV from 1065043-1065915, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene"
>YOR386W PHR1 SGDID:S000005913, Chr XV from 1066839-1068536, Verified ORF, "DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p"
>YOR387C YOR387C SGDID:S000005914, Chr XV from 1070241-1069621, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; regulated by the metal-responsive Aft1p transcription factor; highly inducible in zinc-depleted conditions; localizes to the soluble fraction"
>YOR388C FDH1 SGDID:S000005915, Chr XV from 1072923-1071793, reverse complement, Verified ORF, "NAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formate"
>YOR389W YOR389W SGDID:S000005916, Chr XV from 1074213-1076087, Uncharacterized ORF, "Putative protein of unknown function; expression regulated by copper levels"
>YOR390W YOR390W SGDID:S000005917, Chr XV from 1076784-1077911, Uncharacterized ORF, "Putative protein of unknown function"
>YOR391C HSP33 SGDID:S000005918, Chr XV from 1079258-1078545, reverse complement, Verified ORF, "Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease"
>YOR392W YOR392W SGDID:S000005919, Chr XV from 1079282-1079725, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; gene expression induced by heat"
>YOR393W ERR1 SGDID:S000005920, Chr XV from 1080276-1081589, Verified ORF, "Protein of unknown function, has similarity to enolases"
>YOR394C-A YOR394C-A SGDID:S000028718, Chr XV from 1084369-1084202, reverse complement, Uncharacterized ORF, "Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YOR394W PAU21 SGDID:S000005921, Chr XV from 1082718-1083212, Verified ORF, "Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau22p; encodes 2 proteins that are translated from 2 different start codons"
>YOR396C-A YOR396C-A SGDID:S000028719, Chr XV from 1090497-1090015, reverse complement, Dubious ORF, "Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YOR396W YRF1-8 SGDID:S000007526, Chr XV from 1085473-1090863, Uncharacterized ORF, "One of several telomeric Y' element-encoded DNA helicases, known as Y'-Help1 (Y'-HELicase Protein 1)"
>YPL001W HAT1 SGDID:S000005922, Chr XVI from 554605-555729, Verified ORF, "Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair"
>YPL002C SNF8 SGDID:S000005923, Chr XVI from 554328-553627, reverse complement, Verified ORF, "Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression"
>YPL003W ULA1 SGDID:S000005924, Chr XVI from 552020-553408, Verified ORF, "Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation"
>YPL004C LSP1 SGDID:S000005925, Chr XVI from 551657-550632, reverse complement, Verified ORF, "Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways"
>YPL005W AEP3 SGDID:S000005926, Chr XVI from 548486-550306, Verified ORF, "Peripheral mitochondrial inner membrane protein, located on the matrix face of the membrane; stabilizes the bicistronic AAP1-ATP6 mRNA encoding subunits 6 and 8 of the ATP synthase complex"
>YPL006W NCR1 SGDID:S000005927, Chr XVI from 544631-548143, Verified ORF, "Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein"
>YPL007C TFC8 SGDID:S000005928, Chr XVI from 543848-542082, reverse complement, Verified ORF, "One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90"
>YPL008W CHL1 SGDID:S000005929, Chr XVI from 539385-541970, Verified ORF, "Probable DNA helicase involved in sister-chromatid cohesion and genome integrity; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member"
>YPL009C TAE2 SGDID:S000005930, Chr XVI from 538936-535820, reverse complement, Verified ORF, "Protein of unknown function, involved in protein translation; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"
>YPL010W RET3 SGDID:S000005931, Chr XVI from 535018-535587, Verified ORF, "Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER"
>YPL011C TAF3 SGDID:S000005932, Chr XVI from 534703-533642, reverse complement, Verified ORF, "TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation"
>YPL012W RRP12 SGDID:S000005933, Chr XVI from 529723-533409, Verified ORF, "Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; contains HEAT-repeats"
>YPL013C MRPS16 SGDID:S000005934, Chr XVI from 529350-528985, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the small subunit"
>YPL014W YPL014W SGDID:S000005935, Chr XVI from 527547-528692, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus"
>YPL015C HST2 SGDID:S000005936, Chr XVI from 526883-525810, reverse complement, Verified ORF, "Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro"
>YPL016W SWI1 SGDID:S000005937, Chr XVI from 521014-524958, Verified ORF, "Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]"
>YPL017C IRC15 SGDID:S000005938, Chr XVI from 520233-518734, reverse complement, Verified ORF, "Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci"
>YPL018W CTF19 SGDID:S000005939, Chr XVI from 517651-518760, Verified ORF, "Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly"
>YPL019C VTC3 SGDID:S000005940, Chr XVI from 517018-514511, reverse complement, Verified ORF, "Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion"
>YPL020C ULP1 SGDID:S000005941, Chr XVI from 514178-512313, reverse complement, Verified ORF, "Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase; sequestered to the nucleolus under stress conditions"
>YPL021W ECM23 SGDID:S000005942, Chr XVI from 511101-511664, Verified ORF, "Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p"
>YPL022W RAD1 SGDID:S000005943, Chr XVI from 506697-509999, Verified ORF, "Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein"
>YPL023C MET12 SGDID:S000005944, Chr XVI from 506312-504339, reverse complement, Verified ORF, "Protein with methylenetetrahydrofolate reductase (MTHFR) activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of MTHFR"
>YPL024W RMI1 SGDID:S000005945, Chr XVI from 503517-504242, Verified ORF, "Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex; stimulates superhelical relaxing and ssDNA binding activities of Top3p; involved in response to DNA damage; null mutants display increased rates of recombination and delayed S phase"
>YPL025C YPL025C SGDID:S000005946, Chr XVI from 503030-502473, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YPL026C SKS1 SGDID:S000005947, Chr XVI from 502183-500675, reverse complement, Verified ORF, "Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway"
>YPL027W SMA1 SGDID:S000005948, Chr XVI from 499665-500402, Verified ORF, "Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p"
>YPL028W ERG10 SGDID:S000005949, Chr XVI from 498096-499292, Verified ORF, "Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis"
>YPL029W SUV3 SGDID:S000005950, Chr XVI from 495506-497719, Verified ORF, "ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron"
>YPL030W TRM44 SGDID:S000005951, Chr XVI from 493543-495246, Verified ORF, "tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene"
>YPL031C PHO85 SGDID:S000005952, Chr XVI from 492918-492018,493037-493021, reverse complement, Verified ORF, "Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle"
>YPL032C SVL3 SGDID:S000005953, Chr XVI from 491364-488887, reverse complement, Verified ORF, "Protein of unknown function, mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck"
>YPL033C SRL4 SGDID:S000005954, Chr XVI from 488207-487362, reverse complement, Verified ORF, "Protein of unknown function; involved in regulation of dNTP production; null mutant suppresses the lethality of lcd1 and rad53 mutations; expression is induced by Kar4p"
>YPL034W YPL034W SGDID:S000005955, Chr XVI from 486712-487209, Uncharacterized ORF, "Putative protein of unknown function; YPL034W is not essential gene"
>YPL035C YPL035C SGDID:S000005956, Chr XVI from 486911-486564, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene"
>YPL036W PMA2 SGDID:S000005957, Chr XVI from 482843-485686, Verified ORF, "Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential"
>YPL037C EGD1 SGDID:S000005958, Chr XVI from 481901-481428, reverse complement, Verified ORF, "Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b"
>YPL038W MET31 SGDID:S000005959, Chr XVI from 480535-481068, Verified ORF, "Zinc-finger DNA-binding protein, involved in transcriptional regulation of the methionine biosynthetic genes, similar to Met32p"
>YPL038W-A YPL038W-A SGDID:S000028588, Chr XVI from 480182-480373, Uncharacterized ORF, "Putative protein of unknown function; identified by fungal homology and RT-PCR"
>YPL039W YPL039W SGDID:S000005960, Chr XVI from 479225-480175, Uncharacterized ORF, "Putative protein of unknown function; YPL039W is not an essential gene"
>YPL040C ISM1 SGDID:S000005961, Chr XVI from 479001-475993, reverse complement, Verified ORF, "Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth"
>YPL041C YPL041C SGDID:S000005962, Chr XVI from 475741-475118, reverse complement, Uncharacterized ORF, "Protein of unknown function involved in maintenance of proper telomere length"
>YPL042C SSN3 SGDID:S000005963, Chr XVI from 474707-473040, reverse complement, Verified ORF, "Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression"
>YPL043W NOP4 SGDID:S000005964, Chr XVI from 469939-471996, Verified ORF, "Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)"
>YPL044C YPL044C SGDID:S000005965, Chr XVI from 470474-469926, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W"
>YPL045W VPS16 SGDID:S000005966, Chr XVI from 467260-469656, Verified ORF, "Subunit of the vacuole fusion and protein sorting HOPS complex and the CORVET tethering complex; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages"
>YPL046C ELC1 SGDID:S000005967, Chr XVI from 466943-466644, reverse complement, Verified ORF, "Elongin C, involved in transcription elongation as a heterodimer with Ela1p; required for ubiquitin-dependent degradation of Rpo21p; plays a role in global genomic nucleotide excision repair; expression highly upregulated during sporulation"
>YPL047W SGF11 SGDID:S000005968, Chr XVI from 465962-466261, Verified ORF, "Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation"
>YPL048W CAM1 SGDID:S000005969, Chr XVI from 464401-465648, Verified ORF, "Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma"
>YPL049C DIG1 SGDID:S000005970, Chr XVI from 463839-462481, reverse complement, Verified ORF, "MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p"
>YPL050C MNN9 SGDID:S000005971, Chr XVI from 461966-460779, reverse complement, Verified ORF, "Subunit of Golgi mannosyltransferase complex also containing Anp1p, Mnn10p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; forms a separate complex with Van1p that is also involved in backbone elongation"
>YPL051W ARL3 SGDID:S000005972, Chr XVI from 459963-460559, Verified ORF, "GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor"
>YPL052W OAZ1 SGDID:S000005973, Chr XVI from 458799-459005,459007-459678, Verified ORF, "Regulator of ornithine decarboxylase (Spe1p), antizyme that binds to Spe1p to regulate ubiquitin-independent degradation; ribosomal frameshifting during synthesis of Oaz1p and its ubiquitin-mediated degradation are both polyamine-regulated"
>YPL053C KTR6 SGDID:S000005974, Chr XVI from 458458-457118, reverse complement, Verified ORF, "Probable mannosylphosphate transferase involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family"
>YPL054W LEE1 SGDID:S000005975, Chr XVI from 455759-456664, Verified ORF, "Zinc-finger protein of unknown function"
>YPL055C LGE1 SGDID:S000005976, Chr XVI from 454990-453992, reverse complement, Verified ORF, "Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division"
>YPL056C LCL1 SGDID:S000005977, Chr XVI from 453735-453430, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan"
>YPL057C SUR1 SGDID:S000005978, Chr XVI from 453057-451909, reverse complement, Verified ORF, "Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p"
>YPL058C PDR12 SGDID:S000005979, Chr XVI from 450377-445842, reverse complement, Verified ORF, "Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity"
>YPL059W GRX5 SGDID:S000005980, Chr XVI from 444579-445031, Verified ORF, "Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; mitochondrial matrix protein involved in the synthesis/assembly of iron-sulfur centers; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p"
>YPL060C-A YPL060C-A SGDID:S000007388, Chr XVI from 442742-439428, reverse complement, pseudogene, "TyA Gag protein; the main structural constituent of virus-like particles (VLPs)"
>YPL060W MFM1 SGDID:S000005981, Chr XVI from 434523-435764, Verified ORF, "Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p"
>YPL061W ALD6 SGDID:S000005982, Chr XVI from 432588-434090, Verified ORF, "Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress"
>YPL062W YPL062W SGDID:S000005983, Chr XVI from 431895-432299, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation"
>YPL063W TIM50 SGDID:S000005984, Chr XVI from 429939-431369, Verified ORF, "Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel"
>YPL064C CWC27 SGDID:S000005985, Chr XVI from 429616-428711, reverse complement, Verified ORF, "Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p"
>YPL065W VPS28 SGDID:S000005986, Chr XVI from 427927-428655, Verified ORF, "Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p"
>YPL066W YPL066W SGDID:S000005987, Chr XVI from 426233-427672, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source"
>YPL067C YPL067C SGDID:S000005988, Chr XVI from 425847-425251, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene"
>YPL068C YPL068C SGDID:S000005989, Chr XVI from 425096-424215, reverse complement, Uncharacterized ORF, "Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and is induced in response to the DNA-damaging agent MMS"
>YPL069C BTS1 SGDID:S000005990, Chr XVI from 423892-422885, reverse complement, Verified ORF, "Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic"
>YPL070W MUK1 SGDID:S000005991, Chr XVI from 420948-422786, Verified ORF, "Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation"
>YPL071C YPL071C SGDID:S000005992, Chr XVI from 420518-420048, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus"
>YPL072W UBP16 SGDID:S000005993, Chr XVI from 418512-420011, Verified ORF, "Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria"
>YPL073C YPL073C SGDID:S000005994, Chr XVI from 418984-418499, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with verified gene UBP16/YPL072W; may interact with ribosome based on co-purification experiments"
>YPL074W YTA6 SGDID:S000005995, Chr XVI from 415763-418027, Verified ORF, "Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family, localized to the cortex of mother cells but not to daughter cells"
>YPL075W GCR1 SGDID:S000005996, Chr XVI from 412254-412261,413013-415362, Verified ORF, "Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p"
>YPL076W GPI2 SGDID:S000005997, Chr XVI from 410443-411285, Verified ORF, "Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein"
>YPL077C YPL077C SGDID:S000005998, Chr XVI from 410090-409368, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene"
>YPL078C ATP4 SGDID:S000005999, Chr XVI from 408744-408010, reverse complement, Verified ORF, "Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated"
>YPL079W RPL21B SGDID:S000006000, Chr XVI from 406636-406646,407068-407539, Verified ORF, "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Ap and has similarity to rat L21 ribosomal protein"
>YPL080C YPL080C SGDID:S000006001, Chr XVI from 406498-406172, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YPL081W RPS9A SGDID:S000006002, Chr XVI from 404950-404956,405458-406044, Verified ORF, "Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Bp and has similarity to E. coli S4 and rat S9 ribosomal proteins"
>YPL082C MOT1 SGDID:S000006003, Chr XVI from 404083-398480, reverse complement, Verified ORF, "Essential abundant protein involved in regulation of transcription, removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity"
>YPL083C SEN54 SGDID:S000006004, Chr XVI from 398105-396702, reverse complement, Verified ORF, "Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p"
>YPL084W BRO1 SGDID:S000006005, Chr XVI from 394038-396572, Verified ORF, "Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes"
>YPL085W SEC16 SGDID:S000006006, Chr XVI from 387067-393654, Verified ORF, "COPII vesicle coat protein required for ER transport vesicle budding; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p"
>YPL086C ELP3 SGDID:S000006007, Chr XVI from 386446-384773, reverse complement, Verified ORF, "Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin"
>YPL087W YDC1 SGDID:S000006008, Chr XVI from 383455-384408, Verified ORF, "Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity"
>YPL088W YPL088W SGDID:S000006009, Chr XVI from 381965-382993, Uncharacterized ORF, "Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance"
>YPL089C RLM1 SGDID:S000006010, Chr XVI from 381150-379120, reverse complement, Verified ORF, "MADS-box transcription factor, component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p"
>YPL090C RPS6A SGDID:S000006011, Chr XVI from 377995-377291,378395-378390, reverse complement, Verified ORF, "Protein component of the small (40S) ribosomal subunit; identical to Rps6Bp and has similarity to rat S6 ribosomal protein"
>YPL091W GLR1 SGDID:S000006012, Chr XVI from 375502-376953, Verified ORF, "Cytosolic and mitochondrial glutathione oxidoreductase, converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia"
>YPL092W SSU1 SGDID:S000006013, Chr XVI from 373793-375169, Verified ORF, "Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein"
>YPL093W NOG1 SGDID:S000006014, Chr XVI from 370978-372921, Verified ORF, "Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins"
>YPL094C SEC62 SGDID:S000006015, Chr XVI from 370663-369839, reverse complement, Verified ORF, "Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER"
>YPL095C EEB1 SGDID:S000006016, Chr XVI from 369441-368071, reverse complement, Verified ORF, "Acyl-coenzymeA:ethanol O-acyltransferase responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification"
>YPL096C-A ERI1 SGDID:S000028423, Chr XVI from 366735-366529, reverse complement, Verified ORF, "Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein"
>YPL096W PNG1 SGDID:S000006017, Chr XVI from 366927-368018, Verified ORF, "Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p"
>YPL097W MSY1 SGDID:S000006018, Chr XVI from 364952-366430, Verified ORF, "Mitochondrial tyrosyl-tRNA synthetase"
>YPL098C MGR2 SGDID:S000006019, Chr XVI from 364727-364386, reverse complement, Verified ORF, "Protein required for growth of cells lacking the mitochondrial genome"
>YPL099C AIM43 SGDID:S000006020, Chr XVI from 364068-363520, reverse complement, Verified ORF, "Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss"
>YPL100W ATG21 SGDID:S000006021, Chr XVI from 361872-363362, Verified ORF, "Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein"
>YPL101W ELP4 SGDID:S000006022, Chr XVI from 360209-361579, Verified ORF, "Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity"
>YPL102C YPL102C SGDID:S000006023, Chr XVI from 360305-360003, reverse complement, Dubious ORF, "Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4"
>YPL103C FMP30 SGDID:S000006024, Chr XVI from 359406-358000, reverse complement, Verified ORF, "Protein of unknown function proposed to be involved in N-acylethanolamine metabolism; related to human NAPE-selective phospholipase D enzyme; native protein is detected in highly purified mitochondria in high-throughput studies"
>YPL104W MSD1 SGDID:S000006025, Chr XVI from 355700-357676, Verified ORF, "Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene"
>YPL105C SYH1 SGDID:S000006026, Chr XVI from 355412-352863, reverse complement, Verified ORF, "Protein of unknown function that may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YPL106C SSE1 SGDID:S000006027, Chr XVI from 352275-350194, reverse complement, Verified ORF, "ATPase that is a component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm"
>YPL107W YPL107W SGDID:S000006028, Chr XVI from 349119-349865, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene"
>YPL108W YPL108W SGDID:S000006029, Chr XVI from 348446-348952, Uncharacterized ORF, "Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS"
>YPL109C YPL109C SGDID:S000006030, Chr XVI from 345444-345264,347389-345597, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YPL110C GDE1 SGDID:S000006031, Chr XVI from 344739-341068, reverse complement, Verified ORF, "Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes"
>YPL111W CAR1 SGDID:S000006032, Chr XVI from 339944-340945, Verified ORF, "Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance"
>YPL112C PEX25 SGDID:S000006033, Chr XVI from 338620-337436, reverse complement, Verified ORF, "Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p"
>YPL113C YPL113C SGDID:S000006034, Chr XVI from 337143-335953, reverse complement, Uncharacterized ORF, "Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene"
>YPL114W YPL114W SGDID:S000006035, Chr XVI from 335948-336367, Dubious ORF, "Dubious open reading frame, unlikely to encode a functional protein; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index"
>YPL115C BEM3 SGDID:S000006036, Chr XVI from 335486-332100, reverse complement, Verified ORF, "Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly"
>YPL116W HOS3 SGDID:S000006037, Chr XVI from 329606-331699, Verified ORF, "Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats"
>YPL117C IDI1 SGDID:S000006038, Chr XVI from 328730-327864, reverse complement, Verified ORF, "Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability"
>YPL118W MRP51 SGDID:S000006039, Chr XVI from 326628-327662, Verified ORF, "Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences"
>YPL119C DBP1 SGDID:S000006040, Chr XVI from 326264-324411, reverse complement, Verified ORF, "Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs"
>YPL119C-A YPL119C-A SGDID:S000028859, Chr XVI from 324287-324024, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; identified by expression profiling and mass spectrometry"
>YPL120W VPS30 SGDID:S000006041, Chr XVI from 322071-323744, Verified ORF, "Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; ortholog of the higher eukaryotic gene Beclin 1"
>YPL121C MEI5 SGDID:S000006042, Chr XVI from 321630-320962, reverse complement, Verified ORF, "Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p"
>YPL122C TFB2 SGDID:S000006043, Chr XVI from 320767-319226, reverse complement, Verified ORF, "Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH"
>YPL123C RNY1 SGDID:S000006044, Chr XVI from 318945-317641, reverse complement, Verified ORF, "Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity"
>YPL124W SPC29 SGDID:S000006045, Chr XVI from 316755-317516, Verified ORF, "Inner plaque spindle pole body (SPB) component, links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication"
>YPL125W KAP120 SGDID:S000006046, Chr XVI from 313388-316486, Verified ORF, "Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p"
>YPL126W NAN1 SGDID:S000006047, Chr XVI from 310210-312900, Verified ORF, "U3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA"
>YPL127C HHO1 SGDID:S000006048, Chr XVI from 309604-308828, reverse complement, Verified ORF, "Histone H1, a linker histone required for nucleosome packaging at restricted sites; suppresses DNA repair involving homologous recombination; not required for telomeric silencing, basal transcriptional repression, or efficient sporulation"
>YPL128C TBF1 SGDID:S000006049, Chr XVI from 308221-306533, reverse complement, Verified ORF, "Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression"
>YPL129W TAF14 SGDID:S000006050, Chr XVI from 305298-305306,305412-306137, Verified ORF, "Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes, involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain"
>YPL130W SPO19 SGDID:S000006051, Chr XVI from 304387-305058, Verified ORF, "Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation"
>YPL131W RPL5 SGDID:S000006052, Chr XVI from 303121-304014, Verified ORF, "Protein component of the large (60S) ribosomal subunit with similarity to E. coli L18 and rat L5 ribosomal proteins; binds 5S rRNA and is required for 60S subunit assembly"
>YPL132W COX11 SGDID:S000006053, Chr XVI from 301716-302618, Verified ORF, "Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p"
>YPL133C RDS2 SGDID:S000006054, Chr XVI from 301228-299888, reverse complement, Verified ORF, "Zinc cluster transcriptional activator involved in conferring resistance to ketoconazole"
>YPL134C ODC1 SGDID:S000006055, Chr XVI from 299503-298571, reverse complement, Verified ORF, "Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation"
>YPL135C-A YPL135C-A SGDID:S000028720, Chr XVI from 297851-297678, reverse complement, Dubious ORF, "Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YPL135W ISU1 SGDID:S000006056, Chr XVI from 297553-298050, Verified ORF, "Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable"
>YPL136W YPL136W SGDID:S000006057, Chr XVI from 296286-296654, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene GIP3/YPL137C"
>YPL137C GIP3 SGDID:S000006058, Chr XVI from 296647-292817, reverse complement, Verified ORF, "Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments"
>YPL138C SPP1 SGDID:S000006059, Chr XVI from 292427-291366, reverse complement, Verified ORF, "Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein"
>YPL139C UME1 SGDID:S000006060, Chr XVI from 291051-289669, reverse complement, Verified ORF, "Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p"
>YPL140C MKK2 SGDID:S000006061, Chr XVI from 289034-287514, reverse complement, Verified ORF, "Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p"
>YPL141C FRK1 SGDID:S000006062, Chr XVI from 286061-283464, reverse complement, Verified ORF, "Putative protein kinase; similar to Kin4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3"
>YPL142C YPL142C SGDID:S000006063, Chr XVI from 283003-282686, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit"
>YPL143W RPL33A SGDID:S000006064, Chr XVI from 282122-282140,282666-282970, Verified ORF, "N-terminally acetylated ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Bp and has similarity to rat L35a; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable"
>YPL144W POC4 SGDID:S000006065, Chr XVI from 280480-280926, Verified ORF, "Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions"
>YPL145C KES1 SGDID:S000006066, Chr XVI from 279699-278395, reverse complement, Verified ORF, "Member of the oxysterol binding protein family, which includes seven yeast homologs; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex"
>YPL146C NOP53 SGDID:S000006067, Chr XVI from 277529-276162, reverse complement, Verified ORF, "Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired"
>YPL147W PXA1 SGDID:S000006068, Chr XVI from 273255-275867, Verified ORF, "Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins"
>YPL148C PPT2 SGDID:S000006069, Chr XVI from 272815-272294, reverse complement, Verified ORF, "Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation"
>YPL149W ATG5 SGDID:S000006070, Chr XVI from 271310-272194, Verified ORF, "Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation"
>YPL150W YPL150W SGDID:S000006071, Chr XVI from 268188-270893, Uncharacterized ORF, "Putative protein kinase of unknown cellular role"
>YPL151C PRP46 SGDID:S000006072, Chr XVI from 267535-266180, reverse complement, Verified ORF, "Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs"
>YPL152W RRD2 SGDID:S000006073, Chr XVI from 265028-266104, Verified ORF, "Activator of the phosphotyrosyl phosphatase activity of PP2A,peptidyl-prolyl cis/trans-isomerase; regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex"
>YPL152W-A YPL152W-A SGDID:S000028721, Chr XVI from 264602-264700, Uncharacterized ORF, "Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YPL153C RAD53 SGDID:S000006074, Chr XVI from 264192-261727, reverse complement, Verified ORF, "Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication"
>YPL154C PEP4 SGDID:S000006075, Chr XVI from 260931-259714, reverse complement, Verified ORF, "Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates"
>YPL155C KIP2 SGDID:S000006076, Chr XVI from 259336-257216, reverse complement, Verified ORF, "Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle"
>YPL156C PRM4 SGDID:S000006077, Chr XVI from 256767-255913, reverse complement, Verified ORF, "Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift"
>YPL157W TGS1 SGDID:S000006078, Chr XVI from 254814-255761, Verified ORF, "Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for ribosome synthesis and nucleolar morphology"
>YPL158C AIM44 SGDID:S000006079, Chr XVI from 254310-252034, reverse complement, Verified ORF, "Protein of unknown function; GFP-fusion protein localizes to the bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss"
>YPL159C PET20 SGDID:S000006080, Chr XVI from 251668-250907, reverse complement, Verified ORF, "Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome"
>YPL160W CDC60 SGDID:S000006081, Chr XVI from 246990-250262, Verified ORF, "Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA"
>YPL161C BEM4 SGDID:S000006082, Chr XVI from 246220-244319, reverse complement, Verified ORF, "Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length"
>YPL162C YPL162C SGDID:S000006083, Chr XVI from 244027-243206, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology"
>YPL163C SVS1 SGDID:S000006084, Chr XVI from 242700-241918, reverse complement, Verified ORF, "Cell wall and vacuolar protein, required for wild-type resistance to vanadate"
>YPL164C MLH3 SGDID:S000006085, Chr XVI from 241497-239350, reverse complement, Verified ORF, "Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability"
>YPL165C SET6 SGDID:S000006086, Chr XVI from 239077-237956, reverse complement, Verified ORF, "SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability"
>YPL166W ATG29 SGDID:S000006087, Chr XVI from 237338-237979, Verified ORF, "Autophagy-specific protein that is required for recruitment of other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved"
>YPL167C REV3 SGDID:S000006088, Chr XVI from 237107-232593, reverse complement, Verified ORF, "Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair"
>YPL168W YPL168W SGDID:S000006089, Chr XVI from 231217-232509, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated"
>YPL169C MEX67 SGDID:S000006090, Chr XVI from 230838-229039, reverse complement, Verified ORF, "Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP"
>YPL170W DAP1 SGDID:S000006091, Chr XVI from 228314-228772, Verified ORF, "Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis"
>YPL171C OYE3 SGDID:S000006092, Chr XVI from 227371-226169, reverse complement, Verified ORF, "Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death"
>YPL172C COX10 SGDID:S000006093, Chr XVI from 225741-224353, reverse complement, Verified ORF, "Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders"
>YPL173W MRPL40 SGDID:S000006094, Chr XVI from 223143-224036, Verified ORF, "Mitochondrial ribosomal protein of the large subunit"
>YPL174C NIP100 SGDID:S000006095, Chr XVI from 222773-220167, reverse complement, Verified ORF, "Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued)"
>YPL175W SPT14 SGDID:S000006096, Chr XVI from 218630-218646,218747-220088, Verified ORF, "UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins"
>YPL176C TRE1 SGDID:S000006097, Chr XVI from 218363-216012, reverse complement, Verified ORF, "Plasma membrane protein that binds to Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; function is redundant with that of Tre2p; has similarity to transferrin receptors"
>YPL177C CUP9 SGDID:S000006098, Chr XVI from 213962-213042, reverse complement, Verified ORF, "Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription"
>YPL178W CBC2 SGDID:S000006099, Chr XVI from 212158-212784, Verified ORF, "Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif"
>YPL179W PPQ1 SGDID:S000006100, Chr XVI from 208157-209806, Verified ORF, "Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors"
>YPL180W TCO89 SGDID:S000006101, Chr XVI from 205248-207647, Verified ORF, "Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin"
>YPL181W CTI6 SGDID:S000006102, Chr XVI from 203421-204941, Verified ORF, "Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain"
>YPL182C YPL182C SGDID:S000006103, Chr XVI from 203689-203306, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W"
>YPL183C RTT10 SGDID:S000006104, Chr XVI from 202536-199495, reverse complement, Verified ORF, "Cytoplasmic protein with a role in regulation of Ty1 transposition"
>YPL183W-A RTC6 SGDID:S000007224, Chr XVI from 199095-199376, Verified ORF, "Protein involved translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein encoded in the nucleus"
>YPL184C MRN1 SGDID:S000006105, Chr XVI from 197788-195950, reverse complement, Verified ORF, "RNA-binding protein proposed to be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES)"
>YPL185W YPL185W SGDID:S000006106, Chr XVI from 195253-195648, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C"
>YPL186C UIP4 SGDID:S000006107, Chr XVI from 195426-194512, reverse complement, Verified ORF, "Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope"
>YPL187W MF(ALPHA)1 SGDID:S000006108, Chr XVI from 193648-194145, Verified ORF, "Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor"
>YPL188W POS5 SGDID:S000006109, Chr XVI from 191406-192650, Verified ORF, "Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress"
>YPL189C-A COA2 SGDID:S000028527, Chr XVI from 188513-188307, reverse complement, Verified ORF, "Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p"
>YPL189W GUP2 SGDID:S000006110, Chr XVI from 189154-190983, Verified ORF, "Probable membrane protein with a possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; Gup1p homolog"
>YPL190C NAB3 SGDID:S000006111, Chr XVI from 187725-185317, reverse complement, Verified ORF, "Single stranded RNA binding protein; acidic ribonucleoprotein; required for termination of non-poly(A) transcripts and efficient splicing; interacts with Nrd1p"
>YPL191C YPL191C SGDID:S000006112, Chr XVI from 184679-183597, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"
>YPL192C PRM3 SGDID:S000006113, Chr XVI from 183056-182655, reverse complement, Verified ORF, "Pheromone-regulated protein required for nuclear envelope fusion during karyogamy; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body"
>YPL193W RSA1 SGDID:S000006114, Chr XVI from 181403-182548, Verified ORF, "Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly"
>YPL194W DDC1 SGDID:S000006115, Chr XVI from 179277-181115, Verified ORF, "DNA damage checkpoint protein, part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate"
>YPL195W APL5 SGDID:S000006116, Chr XVI from 176223-179021, Verified ORF, "Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function"
>YPL196W OXR1 SGDID:S000006117, Chr XVI from 175043-175864, Verified ORF, "Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes"
>YPL197C YPL197C SGDID:S000006118, Chr XVI from 174756-174343, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B"
>YPL198W RPL7B SGDID:S000006119, Chr XVI from 173152-173162,173572-173665,174073-174702, Verified ORF, "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Ap and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)"
>YPL199C YPL199C SGDID:S000006120, Chr XVI from 172755-172033, reverse complement, Uncharacterized ORF, "Putative protein of unknown function, predicted to be palmitoylated"
>YPL200W CSM4 SGDID:S000006121, Chr XVI from 171484-171954, Verified ORF, "Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements"
>YPL201C YIG1 SGDID:S000006122, Chr XVI from 171155-169770, reverse complement, Verified ORF, "Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol"
>YPL202C AFT2 SGDID:S000006123, Chr XVI from 169338-168088, reverse complement, Verified ORF, "Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; similar to Aft1p"
>YPL203W TPK2 SGDID:S000006124, Chr XVI from 166256-167398, Verified ORF, "cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase"
>YPL204W HRR25 SGDID:S000006125, Chr XVI from 164276-165760, Verified ORF, "Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)"
>YPL205C YPL205C SGDID:S000006126, Chr XVI from 164266-163922, reverse complement, Dubious ORF, "Hypothetical protein; deletion of locus affects telomere length"
>YPL206C PGC1 SGDID:S000006127, Chr XVI from 163597-162632, reverse complement, Verified ORF, "Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs"
>YPL207W TYW1 SGDID:S000006128, Chr XVI from 159909-162341, Verified ORF, "Protein required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions"
>YPL208W RKM1 SGDID:S000006129, Chr XVI from 157842-159593, Verified ORF, "SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit protein L23a (RPL23A and RPL23B)"
>YPL209C IPL1 SGDID:S000006130, Chr XVI from 157593-156490, reverse complement, Verified ORF, "Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase"
>YPL210C SRP72 SGDID:S000006131, Chr XVI from 156212-154290, reverse complement, Verified ORF, "Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane"
>YPL211W NIP7 SGDID:S000006132, Chr XVI from 153495-154040, Verified ORF, "Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p"
>YPL212C PUS1 SGDID:S000006133, Chr XVI from 153149-151515, reverse complement, Verified ORF, "tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA"
>YPL213W LEA1 SGDID:S000006134, Chr XVI from 150614-151330, Verified ORF, "Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein"
>YPL214C THI6 SGDID:S000006135, Chr XVI from 150191-148569, reverse complement, Verified ORF, "Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern"
>YPL215W CBP3 SGDID:S000006136, Chr XVI from 147416-148423, Verified ORF, "Mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex); interacts with Cbp4p and function is partially redundant with that of Cbp4p"
>YPL216W YPL216W SGDID:S000006137, Chr XVI from 143821-147129, Uncharacterized ORF, "Putative protein of unknown function; YPL216W is not an essential gene"
>YPL217C BMS1 SGDID:S000006138, Chr XVI from 143171-139620, reverse complement, Verified ORF, "GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p"
>YPL218W SAR1 SGDID:S000006139, Chr XVI from 138698-138725,138865-139409, Verified ORF, "GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport"
>YPL219W PCL8 SGDID:S000006140, Chr XVI from 136750-138228, Verified ORF, "Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation"
>YPL220W RPL1A SGDID:S000006141, Chr XVI from 135790-136443, Verified ORF, "N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Bp and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal"
>YPL221W FLC1 SGDID:S000006142, Chr XVI from 133043-135424, Verified ORF, "Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance"
>YPL222C-A YPL222C-A SGDID:S000028722, Chr XVI from 132115-131870, reverse complement, Dubious ORF, "Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YPL222W FMP40 SGDID:S000006143, Chr XVI from 130162-132228, Uncharacterized ORF, "Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YPL223C GRE1 SGDID:S000006144, Chr XVI from 129138-128632, reverse complement, Verified ORF, "Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway"
>YPL224C MMT2 SGDID:S000006145, Chr XVI from 128088-126634, reverse complement, Verified ORF, "Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p"
>YPL225W YPL225W SGDID:S000006146, Chr XVI from 126006-126446, Verified ORF, "Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"
>YPL226W NEW1 SGDID:S000006147, Chr XVI from 121767-125357, Verified ORF, "ATP binding cassette protein that cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction"
>YPL227C ALG5 SGDID:S000006148, Chr XVI from 121167-120163, reverse complement, Verified ORF, "UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum"
>YPL228W CET1 SGDID:S000006149, Chr XVI from 118382-120031, Verified ORF, "Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide"
>YPL229W YPL229W SGDID:S000006150, Chr XVI from 117067-117687, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL229W is not an essential gene"
>YPL230W USV1 SGDID:S000006151, Chr XVI from 115312-116487, Verified ORF, "Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesis"
>YPL231W FAS2 SGDID:S000006152, Chr XVI from 108652-114315, Verified ORF, "Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities"
>YPL232W SSO1 SGDID:S000006153, Chr XVI from 107275-108147, Verified ORF, "Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p"
>YPL233W NSL1 SGDID:S000006154, Chr XVI from 106172-106822, Verified ORF, "Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation"
>YPL234C VMA11 SGDID:S000006155, Chr XVI from 105440-104946, reverse complement, Verified ORF, "Vacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen"
>YPL235W RVB2 SGDID:S000006156, Chr XVI from 103232-104647, Verified ORF, "Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; also referred to as reptin; member of the RUVB-like protein family"
>YPL236C YPL236C SGDID:S000006157, Chr XVI from 102702-101608, reverse complement, Uncharacterized ORF
>YPL237W SUI3 SGDID:S000006158, Chr XVI from 100496-101353, Verified ORF, "Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding"
>YPL238C YPL238C SGDID:S000006159, Chr XVI from 100863-100474, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W"
>YPL239W YAR1 SGDID:S000006160, Chr XVI from 99484-100086, Verified ORF, "Cytoplasmic ankyrin-repeat containing protein of unknown function, proposed to link the processes of 40S ribosomal subunit biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock"
>YPL240C HSP82 SGDID:S000006161, Chr XVI from 98625-96496, reverse complement, Verified ORF, "Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p"
>YPL241C CIN2 SGDID:S000006162, Chr XVI from 96153-95372,96258-96234, reverse complement, Verified ORF, "GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2"
>YPL242C IQG1 SGDID:S000006163, Chr XVI from 95109-90622, reverse complement, Verified ORF, "Essential protein required for determination of budding pattern, promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family"
>YPL243W SRP68 SGDID:S000006164, Chr XVI from 88517-90316, Verified ORF, "Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane"
>YPL244C HUT1 SGDID:S000006165, Chr XVI from 88033-87014, reverse complement, Verified ORF, "Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1"
>YPL245W YPL245W SGDID:S000006166, Chr XVI from 85586-86950, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm"
>YPL246C RBD2 SGDID:S000006167, Chr XVI from 85297-84509, reverse complement, Verified ORF, "Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p"
>YPL247C YPL247C SGDID:S000006168, Chr XVI from 84196-82625, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest"
>YPL248C GAL4 SGDID:S000006169, Chr XVI from 82356-79711, reverse complement, Verified ORF, "DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p"
>YPL249C GYP5 SGDID:S000006170, Chr XVI from 79353-76669, reverse complement, Verified ORF, "GTPase-activating protein (GAP) for yeast Rab family members, involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p"
>YPL249C-A RPL36B SGDID:S000006438, Chr XVI from 75985-75699,76239-76224, reverse complement, Verified ORF, "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Ap and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA"
>YPL250C ICY2 SGDID:S000006171, Chr XVI from 74719-74309, reverse complement, Verified ORF, "Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate"
>YPL250W-A YPL250W-A SGDID:S000028589, Chr XVI from 75702-75989, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified ORF RPL36B/YPL249C-A; identified by fungal homology and RT-PCR"
>YPL251W YPL251W SGDID:S000006172, Chr XVI from 73625-73927, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C"
>YPL252C YAH1 SGDID:S000006173, Chr XVI from 73881-73363, reverse complement, Verified ORF, "Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin"
>YPL253C VIK1 SGDID:S000006174, Chr XVI from 73006-71063, reverse complement, Verified ORF, "Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p"
>YPL254W HFI1 SGDID:S000006175, Chr XVI from 69485-70951, Verified ORF, "Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions"
>YPL255W BBP1 SGDID:S000006176, Chr XVI from 67725-68882, Verified ORF, "Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p"
>YPL256C CLN2 SGDID:S000006177, Chr XVI from 66614-64977, reverse complement, Verified ORF, "G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)"
>YPL257W YPL257W SGDID:S000006178, Chr XVI from 63279-63860, Uncharacterized ORF, "Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene"
>YPL257W-A YPL257W-A SGDID:S000007357, Chr XVI from 56748-58070, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YPL257W-B YPL257W-B SGDID:S000007358, Chr XVI from 56748-58052,58054-62016, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YPL258C THI21 SGDID:S000006179, Chr XVI from 55153-53498, reverse complement, Verified ORF, "Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; Thi20p also has this activity"
>YPL259C APM1 SGDID:S000006180, Chr XVI from 52671-51244, reverse complement, Verified ORF, "Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting"
>YPL260W YPL260W SGDID:S000006181, Chr XVI from 49303-50958, Uncharacterized ORF, "Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene"
>YPL261C YPL261C SGDID:S000006182, Chr XVI from 49304-48996, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YPL260W"
>YPL262W FUM1 SGDID:S000006183, Chr XVI from 47336-48802, Verified ORF, "Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria"
>YPL263C KEL3 SGDID:S000006184, Chr XVI from 46506-44551, reverse complement, Verified ORF, "Cytoplasmic protein of unknown function"
>YPL264C YPL264C SGDID:S000006185, Chr XVI from 44344-43283, reverse complement, Uncharacterized ORF, "Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene"
>YPL265W DIP5 SGDID:S000006186, Chr XVI from 41043-42869, Verified ORF, "Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly"
>YPL266W DIM1 SGDID:S000006187, Chr XVI from 39121-40077, Verified ORF, "Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing"
>YPL267W ACM1 SGDID:S000006188, Chr XVI from 38169-38798, Verified ORF, "Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein"
>YPL268W PLC1 SGDID:S000006189, Chr XVI from 35236-37845, Verified ORF, "Phospholipase C, hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate the signaling molecules inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG); involved in regulating many cellular processes"
>YPL269W KAR9 SGDID:S000006190, Chr XVI from 33013-34947, Verified ORF, "Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase"
>YPL270W MDL2 SGDID:S000006191, Chr XVI from 30482-32803, Verified ORF, "Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis"
>YPL271W ATP15 SGDID:S000006192, Chr XVI from 30079-30267, Verified ORF, "Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated"
>YPL272C YPL272C SGDID:S000006193, Chr XVI from 28164-26611, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene"
>YPL273W SAM4 SGDID:S000006194, Chr XVI from 25087-26064, Verified ORF, "S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio"
>YPL274W SAM3 SGDID:S000006195, Chr XVI from 22938-24701, Verified ORF, "High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p"
>YPL275W FDH2 SGDID:S000006196, Chr XVI from 18369-19079, pseudogene, "NAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formate; YPL275W and YPL276W comprise a continuous open reading frame in some S. cerevisiae strains but not in the genomic reference strain S288C"
>YPL276W YPL276W SGDID:S000006197, Chr XVI from 17948-18385, pseudogene, "NAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formate; YPL275W and YPL276W comprise a continuous open reading frame in some S. cerevisiae strains but not in the genomic reference strain S288C"
>YPL277C YPL277C SGDID:S000006198, Chr XVI from 16868-15405, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; localized to the membranes; gene expression regulated by copper levels"
>YPL278C YPL278C SGDID:S000006199, Chr XVI from 15355-15053, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; gene expression regulated by copper levels"
>YPL279C YPL279C SGDID:S000006200, Chr XVI from 14355-13228, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YPL280W HSP32 SGDID:S000006201, Chr XVI from 11887-12600, Uncharacterized ORF, "Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp33p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease"
>YPL281C ERR2 SGDID:S000006202, Chr XVI from 10870-9557, reverse complement, Verified ORF, "Protein of unknown function, has similarity to enolases"
>YPL282C PAU22 SGDID:S000006203, Chr XVI from 8427-7933, reverse complement, Verified ORF, "Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau21p; encodes 2 proteins that are translated from 2 different start codons"
>YPL283C YRF1-7 SGDID:S000006204, Chr XVI from 5840-280,6007-5989, reverse complement, Verified ORF, "Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p"
>YPL283W-A YPL283W-A SGDID:S000028723, Chr XVI from 1426-2001, Dubious ORF, "Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YPL283W-B YPL283W-B SGDID:S000028724, Chr XVI from 643-1125, Dubious ORF, "Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YPR001W CIT3 SGDID:S000006205, Chr XVI from 556377-557837, Verified ORF, "Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate"
>YPR002C-A YPR002C-A SGDID:S000007254, Chr XVI from 560766-560569, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the Ty1 long terminal repeat, YPRWdelta12"
>YPR002W PDH1 SGDID:S000006206, Chr XVI from 558385-559935, Verified ORF, "Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate"
>YPR003C YPR003C SGDID:S000006207, Chr XVI from 563768-561504, reverse complement, Uncharacterized ORF, "Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene"
>YPR004C AIM45 SGDID:S000006208, Chr XVI from 565041-564007, reverse complement, Verified ORF, "Protein with similarity to mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss"
>YPR005C HAL1 SGDID:S000006209, Chr XVI from 566671-565787, reverse complement, Verified ORF, "Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p"
>YPR006C ICL2 SGDID:S000006210, Chr XVI from 568996-567269, reverse complement, Verified ORF, "2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol"
>YPR007C REC8 SGDID:S000006211, Chr XVI from 571378-569336, reverse complement, Verified ORF, "Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p"
>YPR008W HAA1 SGDID:S000006212, Chr XVI from 573018-575102, Verified ORF, "Transcriptional activator involved in the transcription of TPO2, YRO2, and other genes putatively encoding membrane stress proteins; involved in adaptation to weak acid stress"
>YPR009W SUT2 SGDID:S000006213, Chr XVI from 576552-577358, Verified ORF, "Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p"
>YPR010C RPA135 SGDID:S000006214, Chr XVI from 581196-577585, reverse complement, Verified ORF, "RNA polymerase I second largest subunit A135"
>YPR010C-A YPR010C-A SGDID:S000122558, Chr XVI from 582558-582373,582734-582702, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; conserved among Saccharomyces sensu stricto species"
>YPR011C YPR011C SGDID:S000006215, Chr XVI from 584042-583062, reverse complement, Uncharacterized ORF, "Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YPR012W YPR012W SGDID:S000006216, Chr XVI from 584309-584563, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene"
>YPR013C YPR013C SGDID:S000006217, Chr XVI from 585585-584632, reverse complement, Uncharacterized ORF, "Putative zinc finger protein; YPR013C is not an essential gene"
>YPR014C YPR014C SGDID:S000006218, Chr XVI from 587518-587189, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene"
>YPR015C YPR015C SGDID:S000006219, Chr XVI from 591026-590283, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; overexpression causes a cell cycle delay or arrest"
>YPR016C TIF6 SGDID:S000006220, Chr XVI from 593069-592332, reverse complement, Verified ORF, "Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits"
>YPR016W-A YPR016W-A SGDID:S000007630, Chr XVI from 593096-593356, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YPR017C DSS4 SGDID:S000006221, Chr XVI from 593917-593486, reverse complement, Verified ORF, "Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol"
>YPR018W RLF2 SGDID:S000006222, Chr XVI from 594476-596296, Verified ORF, "Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) with Cac2p and Msi1p that assembles newly synthesized histones onto recently replicated DNA; involved in the maintenance of transcriptionally silent chromatin"
>YPR019W MCM4 SGDID:S000006223, Chr XVI from 596750-599551, Verified ORF, "Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt the DNA prior to replication; accumulates in the nucleus in G1; homolog of S. pombe Cdc21p"
>YPR020W ATP20 SGDID:S000006224, Chr XVI from 599870-600217, Verified ORF, "Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex"
>YPR021C AGC1 SGDID:S000006225, Chr XVI from 603357-600649, reverse complement, Verified ORF, "Mitochondrial amino acid transporter, acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis"
>YPR022C YPR022C SGDID:S000006226, Chr XVI from 607312-603911, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS"
>YPR023C EAF3 SGDID:S000006227, Chr XVI from 610031-608826, reverse complement, Verified ORF, "Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition"
>YPR024W YME1 SGDID:S000006228, Chr XVI from 610481-612724, Verified ORF, "Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; mutation causes an elevated rate of mitochondrial turnover"
>YPR025C CCL1 SGDID:S000006229, Chr XVI from 614558-613377, reverse complement, Verified ORF, "Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters"
>YPR026W ATH1 SGDID:S000006230, Chr XVI from 615379-619014, Verified ORF, "Acid trehalase required for utilization of extracellular trehalose"
>YPR027C YPR027C SGDID:S000006231, Chr XVI from 621258-620425, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YPR028W YOP1 SGDID:S000006232, Chr XVI from 623527-623577,623711-624202, Verified ORF, "Membrane protein that interacts with Yip1p to mediate membrane traffic; interacts with Sey1p to maintain ER morphology; overexpression leads to cell death and accumulation of internal cell membranes"
>YPR029C APL4 SGDID:S000006233, Chr XVI from 626967-624469, reverse complement, Verified ORF, "Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport"
>YPR030W CSR2 SGDID:S000006234, Chr XVI from 627880-631245, Verified ORF, "Nuclear protein proposed to regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p"
>YPR031W NTO1 SGDID:S000006235, Chr XVI from 631515-633761, Verified ORF, "Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3"
>YPR032W SRO7 SGDID:S000006236, Chr XVI from 634123-637224, Verified ORF, "Effector of Rab GTPase Sec4p, forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Sro77p and Drosophila lgl tumor suppressor"
>YPR033C HTS1 SGDID:S000006237, Chr XVI from 639019-637379, reverse complement, Verified ORF, "Cytoplasmic and mitochondrial histidine tRNA synthetase; encoded by a single nuclear gene that specifies two messages; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence"
>YPR034W ARP7 SGDID:S000006238, Chr XVI from 639525-640958, Verified ORF, "Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation"
>YPR035W GLN1 SGDID:S000006239, Chr XVI from 642208-643320, Verified ORF, "Glutamine synthetase (GS), synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation"
>YPR036W VMA13 SGDID:S000006240, Chr XVI from 643836-645272, Verified ORF, "Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase"
>YPR036W-A YPR036W-A SGDID:S000028425, Chr XVI from 645950-646153, Verified ORF, "Protein of unknown function; transcription is regulated by Pdr1p"
>YPR037C ERV2 SGDID:S000006241, Chr XVI from 647038-646448, reverse complement, Verified ORF, "Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER"
>YPR038W IRC16 SGDID:S000006242, Chr XVI from 646836-647195, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YPR037C; null mutant displays increased levels of spontaneous Rad52p foci"
>YPR039W YPR039W SGDID:S000006243, Chr XVI from 647012-647347, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W"
>YPR040W TIP41 SGDID:S000006244, Chr XVI from 647305-648375, Verified ORF, "Protein that interacts physically and genetically with Tap42p, which regulates protein phosphatase 2A; component of the TOR (target of rapamycin) signaling pathway"
>YPR041W TIF5 SGDID:S000006245, Chr XVI from 648704-649921, Verified ORF, "Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2"
>YPR042C PUF2 SGDID:S000006246, Chr XVI from 653662-650435, reverse complement, Verified ORF, "Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins"
>YPR043W RPL43A SGDID:S000006247, Chr XVI from 654166-654167,654571-654847, Verified ORF, "Protein component of the large (60S) ribosomal subunit, identical to Rpl43Bp and has similarity to rat L37a ribosomal protein; null mutation confers a dominant lethal phenotype"
>YPR044C OPI11 SGDID:S000006248, Chr XVI from 654877-654524, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO"
>YPR045C THP3 SGDID:S000006249, Chr XVI from 656552-655140, reverse complement, Verified ORF, "Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes"
>YPR046W MCM16 SGDID:S000006250, Chr XVI from 656799-657344, Verified ORF, "Protein involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA"
>YPR047W MSF1 SGDID:S000006251, Chr XVI from 657529-658938, Verified ORF, "Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase"
>YPR048W TAH18 SGDID:S000006252, Chr XVI from 659182-661053, Verified ORF, "Conserved NAPDH-dependent diflavin reductase, component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress"
>YPR049C ATG11 SGDID:S000006253, Chr XVI from 664673-661137, reverse complement, Verified ORF, "Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS)"
>YPR050C YPR050C SGDID:S000006254, Chr XVI from 665366-664953, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W"
>YPR051W MAK3 SGDID:S000006255, Chr XVI from 664960-665490, Verified ORF, "Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus"
>YPR052C NHP6A SGDID:S000006256, Chr XVI from 665974-665693, reverse complement, Verified ORF, "High-mobility group (HMG) protein that binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Bp; homologous to mammalian HMGB1 and HMGB2"
>YPR053C YPR053C SGDID:S000006257, Chr XVI from 666243-665788, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene NHP6A/YPR052C"
>YPR054W SMK1 SGDID:S000006258, Chr XVI from 666280-667446, Verified ORF, "Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p"
>YPR055W SEC8 SGDID:S000006259, Chr XVI from 667676-670873, Verified ORF, "Essential 121kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis"
>YPR056W TFB4 SGDID:S000006260, Chr XVI from 671126-672142, Verified ORF, "Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p"
>YPR057W BRR1 SGDID:S000006261, Chr XVI from 672471-673496, Verified ORF, "snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed"
>YPR058W YMC1 SGDID:S000006262, Chr XVI from 673751-674674, Verified ORF, "Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc2p"
>YPR059C YPR059C SGDID:S000006263, Chr XVI from 674700-674314, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W"
>YPR060C ARO7 SGDID:S000006264, Chr XVI from 675631-674861, reverse complement, Verified ORF, "Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis"
>YPR061C JID1 SGDID:S000006265, Chr XVI from 676882-675977, reverse complement, Verified ORF, "Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae"
>YPR062W FCY1 SGDID:S000006266, Chr XVI from 677165-677641, Verified ORF, "Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)"
>YPR063C YPR063C SGDID:S000006267, Chr XVI from 678193-677812,678320-678280, reverse complement, Uncharacterized ORF, "ER-localized protein of unknown function"
>YPR064W YPR064W SGDID:S000006268, Chr XVI from 678951-679370, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YPR065W ROX1 SGDID:S000006269, Chr XVI from 679693-680799, Verified ORF, "Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity"
>YPR066W UBA3 SGDID:S000006270, Chr XVI from 681213-682112, Verified ORF, "Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern"
>YPR067W ISA2 SGDID:S000006271, Chr XVI from 682220-682777, Verified ORF, "Protein required for maturation of mitochondrial and cytosolic Fe/S proteins, localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations"
>YPR068C HOS1 SGDID:S000006272, Chr XVI from 684353-682941, reverse complement, Verified ORF, "Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex"
>YPR069C SPE3 SGDID:S000006273, Chr XVI from 685437-684556, reverse complement, Verified ORF, "Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells"
>YPR070W MED1 SGDID:S000006274, Chr XVI from 685898-687598, Verified ORF, "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation"
>YPR071W YPR071W SGDID:S000006275, Chr XVI from 688172-688807, Uncharacterized ORF, "Putative membrane protein; YPR071W is not an essential gene"
>YPR072W NOT5 SGDID:S000006276, Chr XVI from 690107-691789, Verified ORF, "Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation"
>YPR073C LTP1 SGDID:S000006277, Chr XVI from 692418-691933, reverse complement, Verified ORF, "Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine"
>YPR074C TKL1 SGDID:S000006278, Chr XVI from 694838-692796, reverse complement, Verified ORF, "Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids"
>YPR074W-A YPR074W-A SGDID:S000007631, Chr XVI from 695018-695188, Dubious ORF, "Hypothetical protein identified by homology"
>YPR075C OPY2 SGDID:S000006279, Chr XVI from 696819-695737, reverse complement, Verified ORF, "Integral membrane protein that functions in the signaling branch of the high-osmolarity glycerol (HOG) pathway; interacts with Ste50p; overproduction blocks cell cycle arrest in the presence of mating pheromone"
>YPR076W YPR076W SGDID:S000006280, Chr XVI from 696476-696850, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YPR077C YPR077C SGDID:S000006281, Chr XVI from 697502-697131, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression increased by deletion of NAP1"
>YPR078C YPR078C SGDID:S000006282, Chr XVI from 698265-697147, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible"
>YPR079W MRL1 SGDID:S000006283, Chr XVI from 698869-700014, Verified ORF, "Membrane protein with similarity to mammalian mannose-6-phosphate receptors, possibly functions as a sorting receptor in the delivery of vacuolar hydrolases"
>YPR080W TEF1 SGDID:S000006284, Chr XVI from 700594-701970, Verified ORF, "Translational elongation factor EF-1 alpha; also encoded by TEF2; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus"
>YPR081C GRS2 SGDID:S000006285, Chr XVI from 703970-702114, reverse complement, Verified ORF, "Protein with sequence similarity to Grs1p, which is a glycyl-tRNA synthetase; cannot substitute for Grs1p; possible pseudogene that is expressed at very low levels"
>YPR082C DIB1 SGDID:S000006286, Chr XVI from 704656-704225, reverse complement, Verified ORF, "17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein"
>YPR083W MDM36 SGDID:S000006287, Chr XVI from 704854-706593, Verified ORF, "Mitochondrial protein required for normal mitochondrial morphology and inheritance; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission"
>YPR084W YPR084W SGDID:S000006288, Chr XVI from 706972-708342, Uncharacterized ORF, "Putative protein of unknown function"
>YPR085C ASA1 SGDID:S000006289, Chr XVI from 709828-708497, reverse complement, Verified ORF, "Putative protein of unknown function; subunit of the ASTRA complex (Rvb1p, Rvb2p, Tra1p, Tti1p, Tti2, Asa1p and Tra1p) which is part of the chromatin remodeling machinery"
>YPR086W SUA7 SGDID:S000006290, Chr XVI from 710101-711138, Verified ORF, "Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II"
>YPR087W VPS69 SGDID:S000006291, Chr XVI from 711354-711674, Dubious ORF, "Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene SRP54; deletion causes a vacuolar protein sorting defect"
>YPR088C SRP54 SGDID:S000006292, Chr XVI from 713028-711403, reverse complement, Verified ORF, "Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain"
>YPR089W YPR089W SGDID:S000006293, Chr XVI from 713275-715941, Uncharacterized ORF, "Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p"
>YPR091C YPR091C SGDID:S000006295, Chr XVI from 718468-716156, reverse complement, Verified ORF, "Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YPR091C is not an essential gene"
>YPR092W YPR092W SGDID:S000006296, Chr XVI from 718379-718684, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YPR093C ASR1 SGDID:S000006297, Chr XVI from 720424-719558, reverse complement, Verified ORF, "Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein"
>YPR094W RDS3 SGDID:S000006298, Chr XVI from 720637-720960, Verified ORF, "Component of the SF3b subcomplex of the U2 snRNP, zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance"
>YPR095C SYT1 SGDID:S000006299, Chr XVI from 724717-721037, reverse complement, Verified ORF, "Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain"
>YPR096C YPR096C SGDID:S000006300, Chr XVI from 725144-724842, reverse complement, Verified ORF, "Protein of unknown function that may interact with ribosomes, based on co-purification experiments"
>YPR097W YPR097W SGDID:S000006301, Chr XVI from 725394-728615, Verified ORF, "Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
>YPR098C YPR098C SGDID:S000006302, Chr XVI from 729385-728947,729528-729482, reverse complement, Verified ORF, "Protein of unknown function, localized to the mitochondrial outer membrane"
>YPR099C YPR099C SGDID:S000006303, Chr XVI from 730113-729757, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL51/YPR100W"
>YPR100W MRPL51 SGDID:S000006304, Chr XVI from 729791-730213, Verified ORF, "Mitochondrial ribosomal protein of the large subunit"
>YPR101W SNT309 SGDID:S000006305, Chr XVI from 730492-731019, Verified ORF, "Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p"
>YPR102C RPL11A SGDID:S000006306, Chr XVI from 731748-731224, reverse complement, Verified ORF, "Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Bp; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11"
>YPR103W PRE2 SGDID:S000006307, Chr XVI from 732349-733212, Verified ORF, "Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome"
>YPR104C FHL1 SGDID:S000006308, Chr XVI from 736433-733623, reverse complement, Verified ORF, "Regulator of ribosomal protein transcription; has forkhead associated domain that binds phosphorylated proteins; also has forkhead DNA-binding domain but does not bind DNA in vitro; suppresses RNA pol III and splicing factor prp4 mutants"
>YPR105C COG4 SGDID:S000006309, Chr XVI from 739569-736984, reverse complement, Verified ORF, "Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments"
>YPR106W ISR1 SGDID:S000006310, Chr XVI from 740061-741392, Verified ORF, "Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C"
>YPR107C YTH1 SGDID:S000006311, Chr XVI from 742064-741438, reverse complement, Verified ORF, "Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation"
>YPR108W RPN7 SGDID:S000006312, Chr XVI from 742454-743743, Verified ORF, "Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits"
>YPR108W-A YPR108W-A SGDID:S000028590, Chr XVI from 744175-744387, Uncharacterized ORF, "Putative protein of unknown function; identified by fungal homology and RT-PCR"
>YPR109W YPR109W SGDID:S000006313, Chr XVI from 744689-745573, Uncharacterized ORF, "Predicted membrane protein; dipoid deletion strain has high budding index"
>YPR110C RPC40 SGDID:S000006314, Chr XVI from 746835-745828, reverse complement, Verified ORF, "RNA polymerase subunit AC40, common to RNA polymerase I and III"
>YPR111W DBF20 SGDID:S000006315, Chr XVI from 747306-749000, Verified ORF, "Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis"
>YPR112C MRD1 SGDID:S000006316, Chr XVI from 751919-749256, reverse complement, Verified ORF, "Essential conserved protein that is part of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains"
>YPR113W PIS1 SGDID:S000006317, Chr XVI from 752257-752919, Verified ORF, "Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins"
>YPR114W YPR114W SGDID:S000006318, Chr XVI from 753301-754248, Uncharacterized ORF, "Putative protein of unknown function"
>YPR115W RGC1 SGDID:S000006319, Chr XVI from 754877-758128, Verified ORF, "Pleckstrin homology domain containing protein proposed to function as a glycerol channel activator; paralogous to Ask10p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"
>YPR116W RRG8 SGDID:S000006320, Chr XVI from 758648-759481, Verified ORF, "Putative protein of unknown function, required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport"
>YPR117W YPR117W SGDID:S000006321, Chr XVI from 760025-767494, Uncharacterized ORF, "Putative protein of unknown function"
>YPR118W MRI1 SGDID:S000006322, Chr XVI from 767752-768987, Verified ORF, "5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway"
>YPR119W CLB2 SGDID:S000006323, Chr XVI from 771653-773128, Verified ORF, "B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome"
>YPR120C CLB5 SGDID:S000006324, Chr XVI from 775182-773875, reverse complement, Verified ORF, "B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase"
>YPR121W THI22 SGDID:S000006325, Chr XVI from 778583-780301, Verified ORF, "Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis"
>YPR122W AXL1 SGDID:S000006326, Chr XVI from 782045-785671, Verified ORF, "Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells"
>YPR123C YPR123C SGDID:S000006327, Chr XVI from 786575-786141, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR"
>YPR124W CTR1 SGDID:S000006328, Chr XVI from 786208-787428, Verified ORF, "High-affinity copper transporter of the plasma membrane, mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels"
>YPR125W YLH47 SGDID:S000006329, Chr XVI from 787961-789325, Verified ORF, "Mitochondrial inner membrane protein exposed to the mitochondrial matrix, associates with mitochondrial ribosomes, NOT required for respiratory growth; homolog of human Letm1, a protein implicated in Wolf-Hirschhorn syndrome"
>YPR126C YPR126C SGDID:S000006330, Chr XVI from 789385-789077, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YPR127W YPR127W SGDID:S000006331, Chr XVI from 790083-791120, Verified ORF, "Protein of unknown function, differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus"
>YPR128C ANT1 SGDID:S000006332, Chr XVI from 792204-791218, reverse complement, Verified ORF, "Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation"
>YPR129W SCD6 SGDID:S000006333, Chr XVI from 792687-793736, Verified ORF, "Protein containing an Lsm domain; negatively regulates translation initiation via 48S preinitiation complex assembly; may bind RNA and have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1"
>YPR130C YPR130C SGDID:S000006334, Chr XVI from 793781-793374, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YPR131C NAT3 SGDID:S000006335, Chr XVI from 794498-793911, reverse complement, Verified ORF, "Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met"
>YPR132W RPS23B SGDID:S000006336, Chr XVI from 794965-795029,795395-795767, Verified ORF, "Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Ap and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal"
>YPR133C SPN1 SGDID:S000006337, Chr XVI from 797210-795978, reverse complement, Verified ORF, "Protein involved in RNA polymerase II transcription; interacts genetically or physically with RNAP II, TBP, TFIIS, and chromatin remodelling factors; central domain highly conserved throughout eukaryotes; mutations confer an Spt- phenotype"
>YPR133W-A TOM5 SGDID:S000006433, Chr XVI from 797557-797709, Verified ORF, "Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore"
>YPR134W MSS18 SGDID:S000006338, Chr XVI from 798051-798857, Verified ORF, "Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions"
>YPR135W CTF4 SGDID:S000006339, Chr XVI from 799234-802017, Verified ORF, "Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion"
>YPR136C YPR136C SGDID:S000006340, Chr XVI from 802837-802325, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9"
>YPR137C-A YPR137C-A SGDID:S000007359, Chr XVI from 810269-808947, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YPR137C-B YPR137C-B SGDID:S000007360, Chr XVI from 808963-805001,810269-808965, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YPR137W RRP9 SGDID:S000006341, Chr XVI from 802359-804080, Verified ORF, "Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein"
>YPR138C MEP3 SGDID:S000006342, Chr XVI from 812453-810984, reverse complement, Verified ORF, "Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease"
>YPR139C VPS66 SGDID:S000006343, Chr XVI from 814058-813156, reverse complement, Verified ORF, "Cytoplasmic protein of unknown function involved in vacuolar protein sorting."
>YPR140W TAZ1 SGDID:S000006344, Chr XVI from 814391-815536, Verified ORF, "Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome"
>YPR141C KAR3 SGDID:S000006345, Chr XVI from 817923-815734, reverse complement, Verified ORF, "Minus-end-directed microtubule motor that functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating; potential Cdc28p substrate"
>YPR142C YPR142C SGDID:S000006346, Chr XVI from 818693-818130, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing"
>YPR143W RRP15 SGDID:S000006347, Chr XVI from 818323-819075, Verified ORF, "Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs"
>YPR144C NOC4 SGDID:S000006348, Chr XVI from 821423-819765, reverse complement, Verified ORF, "Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits"
>YPR145C-A YPR145C-A SGDID:S000113589, Chr XVI from 824926-824690, reverse complement, Uncharacterized ORF, "Putative protein of unknown function"
>YPR145W ASN1 SGDID:S000006349, Chr XVI from 822620-824338, Verified ORF, "Asparagine synthetase, isozyme of Asn2p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway"
>YPR146C YPR146C SGDID:S000006350, Chr XVI from 825676-825347, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YPR147C YPR147C SGDID:S000006351, Chr XVI from 826559-825645, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS"
>YPR148C YPR148C SGDID:S000006352, Chr XVI from 828140-826833, reverse complement, Verified ORF, "Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern"
>YPR149W NCE102 SGDID:S000006353, Chr XVI from 829918-830439, Verified ORF, "Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)"
>YPR150W YPR150W SGDID:S000006354, Chr XVI from 830999-831520, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C"
>YPR151C SUE1 SGDID:S000006355, Chr XVI from 831675-831055, reverse complement, Verified ORF, "Mitochondrial protein required for degradation of unstable forms of cytochrome c"
>YPR152C URN1 SGDID:S000006356, Chr XVI from 833458-832061, reverse complement, Verified ORF, "Putative protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase"
>YPR153W YPR153W SGDID:S000006357, Chr XVI from 833689-833693,833828-834245, Verified ORF, "Putative protein of unknown function"
>YPR154W PIN3 SGDID:S000006358, Chr XVI from 834565-835212, Verified ORF, "Protein that induces appearance of [PIN+] prion when overproduced"
>YPR155C NCA2 SGDID:S000006359, Chr XVI from 837413-835563, reverse complement, Verified ORF, "Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p"
>YPR156C TPO3 SGDID:S000006360, Chr XVI from 839777-837909, reverse complement, Verified ORF, "Polyamine transport protein specific for spermine; localizes to the plasma membrane; member of the major facilitator superfamily"
>YPR157W YPR157W SGDID:S000006361, Chr XVI from 841266-842669, Uncharacterized ORF, "Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation"
>YPR158C-C YPR158C-C SGDID:S000007361, Chr XVI from 856257-854935, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YPR158C-D YPR158C-D SGDID:S000007362, Chr XVI from 854951-850989,856257-854953, reverse complement, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YPR158W CUR1 SGDID:S000006362, Chr XVI from 843262-844020, Verified ORF, "Protein of unknown function involved in destabilization of [URE3] prions; similar in sequence to Btn2p"
>YPR158W-A YPR158W-A SGDID:S000007363, Chr XVI from 844709-846031, transposable_element_gene, "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag"
>YPR158W-B YPR158W-B SGDID:S000007364, Chr XVI from 844709-846013,846015-849980, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes"
>YPR159C-A YPR159C-A SGDID:S000028725, Chr XVI from 860415-860314, reverse complement, Uncharacterized ORF, "Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YPR159W KRE6 SGDID:S000006363, Chr XVI from 857583-859745, Verified ORF, "Protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; appears functionally redundant with Skn1p"
>YPR160C-A YPR160C-A SGDID:S000028726, Chr XVI from 862861-862577, reverse complement, Dubious ORF, "Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YPR160W GPH1 SGDID:S000006364, Chr XVI from 861306-864014, Verified ORF, "Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway"
>YPR160W-A YPR160W-A SGDID:S000028860, Chr XVI from 861934-862014, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry"
>YPR161C SGV1 SGDID:S000006365, Chr XVI from 866422-864449, reverse complement, Verified ORF, "Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p and the C-terminal repeat domain of Spt5p; regulated by Cak1p"
>YPR162C ORC4 SGDID:S000006366, Chr XVI from 868304-866715, reverse complement, Verified ORF, "Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing"
>YPR163C TIF3 SGDID:S000006367, Chr XVI from 869955-868645, reverse complement, Verified ORF, "Translation initiation factor eIF-4B, has RNA annealing activity; contains an RNA recognition motif and binds to single-stranded RNA"
>YPR164W MMS1 SGDID:S000006368, Chr XVI from 870703-874926, Verified ORF, "Subunit of an E3 ubiquitin ligase complex involved in resolving replication intermediates or preventing the damage caused by blocked replication forks; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay"
>YPR165W RHO1 SGDID:S000006369, Chr XVI from 875368-875997, Verified ORF, "GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)"
>YPR166C MRP2 SGDID:S000006370, Chr XVI from 876629-876282, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the small subunit"
>YPR167C MET16 SGDID:S000006371, Chr XVI from 877632-876847, reverse complement, Verified ORF, "3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism"
>YPR168W NUT2 SGDID:S000006372, Chr XVI from 878076-878549, Verified ORF, "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription"
>YPR169W JIP5 SGDID:S000006373, Chr XVI from 878690-880168, Verified ORF, "Essential protein required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein"
>YPR169W-A YPR169W-A SGDID:S000028591, Chr XVI from 883239-883457, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps two other dubious ORFs: YPR170C and YPR170W-B"
>YPR170C YPR170C SGDID:S000006374, Chr XVI from 883318-882983, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B"
>YPR170W-A YPR170W-A SGDID:S000028861, Chr XVI from 883378-883563, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry"
>YPR170W-B YPR170W-B SGDID:S000028515, Chr XVI from 883239-883387,883487-883595, Uncharacterized ORF, "Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C"
>YPR171W BSP1 SGDID:S000006375, Chr XVI from 883828-885558, Verified ORF, "Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton"
>YPR172W YPR172W SGDID:S000006376, Chr XVI from 885796-886398, Uncharacterized ORF, "Protein of unknown function, transcriptionally activated by Yrm1p along with genes involved in multidrug resistance"
>YPR173C VPS4 SGDID:S000006377, Chr XVI from 887837-886524, reverse complement, Verified ORF, "AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism"
>YPR174C YPR174C SGDID:S000006378, Chr XVI from 888708-888043, reverse complement, Uncharacterized ORF, "Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate"
>YPR175W DPB2 SGDID:S000006379, Chr XVI from 888974-891043, Verified ORF, "Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for normal yeast chromosomal replication; expression peaks at the G1/S phase boundary; potential Cdc28p substrate"
>YPR176C BET2 SGDID:S000006380, Chr XVI from 892078-891101, reverse complement, Verified ORF, "Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p"
>YPR177C YPR177C SGDID:S000006381, Chr XVI from 892684-892313, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex"
>YPR178W PRP4 SGDID:S000006382, Chr XVI from 892332-893729, Verified ORF, "Splicing factor, component of the U4/U6-U5 snRNP complex"
>YPR179C HDA3 SGDID:S000006383, Chr XVI from 895764-893797, reverse complement, Verified ORF, "Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda2p"
>YPR180W AOS1 SGDID:S000006384, Chr XVI from 895961-897004, Verified ORF, "Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability"
>YPR181C SEC23 SGDID:S000006385, Chr XVI from 899667-897361, reverse complement, Verified ORF, "GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport"
>YPR182W SMX3 SGDID:S000006386, Chr XVI from 900194-900454, Verified ORF, "Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F"
>YPR183W DPM1 SGDID:S000006387, Chr XVI from 900755-901558, Verified ORF, "Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation"
>YPR184W GDB1 SGDID:S000006388, Chr XVI from 902044-906654, Verified ORF, "Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria"
>YPR185W ATG13 SGDID:S000006389, Chr XVI from 907218-909434, Verified ORF, "Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling"
>YPR186C PZF1 SGDID:S000006390, Chr XVI from 911022-909733, reverse complement, Verified ORF, "Transcription factor IIIA (TFIIIA); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserved zinc fingers; may also bind 5S rRNA"
>YPR187W RPO26 SGDID:S000006391, Chr XVI from 911257-911276,911353-911800, Verified ORF, "RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit"
>YPR188C MLC2 SGDID:S000006392, Chr XVI from 912479-911988, reverse complement, Verified ORF, "Regulatory light chain for the type II myosin, Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring"
>YPR189W SKI3 SGDID:S000006393, Chr XVI from 912664-916962, Verified ORF, "Ski complex component and TPR protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay"
>YPR190C RPC82 SGDID:S000006394, Chr XVI from 919041-917077, reverse complement, Verified ORF, "RNA polymerase III subunit C82"
>YPR191W QCR2 SGDID:S000006395, Chr XVI from 919381-920487, Verified ORF, "Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme"
>YPR192W AQY1 SGDID:S000006396, Chr XVI from 921860-922777, Verified ORF, "Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance"
>YPR193C HPA2 SGDID:S000006397, Chr XVI from 923379-922909, reverse complement, Verified ORF, "Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity"
>YPR194C OPT2 SGDID:S000006398, Chr XVI from 926937-924304, reverse complement, Verified ORF, "Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles"
>YPR195C YPR195C SGDID:S000006399, Chr XVI from 928294-927965, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>YPR196W YPR196W SGDID:S000006400, Chr XVI from 931376-932788, Uncharacterized ORF, "Putative maltose activator"
>YPR197C YPR197C SGDID:S000006401, Chr XVI from 934461-933898, reverse complement, Dubious ORF, "Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"
>YPR198W SGE1 SGDID:S000006402, Chr XVI from 934034-935665, Verified ORF, "Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations"
>YPR199C ARR1 SGDID:S000006403, Chr XVI from 939032-938148, reverse complement, Verified ORF, "Transcriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compounds"
>YPR200C ARR2 SGDID:S000006404, Chr XVI from 939671-939279, reverse complement, Verified ORF, "Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p"
>YPR201W ARR3 SGDID:S000006405, Chr XVI from 939922-941136, Verified ORF, "Arsenite transporter of the plasma membrane, required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite"
>YPR202W YPR202W SGDID:S000006406, Chr XVI from 943032-943050,943199-943896, Uncharacterized ORF, "Putative protein of unknown function with similarity to telomere-encoded helicases; YPR202W is not an essential gene; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo"
>YPR203W YPR203W SGDID:S000006407, Chr XVI from 943880-944188, Uncharacterized ORF, "Putative protein of unknown function"
>YPR204C-A YPR204C-A SGDID:S000028727, Chr XVI from 947338-946856, reverse complement, Dubious ORF, "Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"
>YPR204W YPR204W SGDID:S000006408, Chr XVI from 944603-947701, Uncharacterized ORF, "Helicase-like protein encoded within the telomeric Y' element"
>Q0010 Q0010 SGDID:S000007257, Chr Mito from 3952-4338, Dubious ORF, "Dubious mitochondrial open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF Q0017"
>Q0017 Q0017 SGDID:S000007258, Chr Mito from 4254-4415, Dubious ORF, "Dubious mitochondrial open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF Q0010"
>Q0032 Q0032 SGDID:S000007259, Chr Mito from 11667-11957, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>Q0045 COX1 SGDID:S000007260, Chr Mito from 13818-13986,16435-16470,18954-18991,20508-20984,21995-22246,23612-23746,25318-25342,26229-26701, Verified ORF, "Subunit I of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits"
>Q0050 AI1 SGDID:S000007261, Chr Mito from 13818-16322, Verified ORF, "Reverse transcriptase required for splicing of the COX1 pre-mRNA, encoded by a mobile group II intron within the mitochondrial COX1 gene"
>Q0055 AI2 SGDID:S000007262, Chr Mito from 13818-13986,16435-18830, Verified ORF, "Reverse transcriptase required for splicing of the COX1 pre-mRNA, encoded by a mobile group II intron within the mitochondrial COX1 gene"
>Q0060 AI3 SGDID:S000007263, Chr Mito from 13818-13986,16435-16470,18954-19996, Verified ORF, "Endonuclease I-SceIII, encoded by a mobile group I intron within the mitochondrial COX1 gene"
>Q0065 AI4 SGDID:S000007264, Chr Mito from 13818-13986,16435-16470,18954-18991,20508-21935, Verified ORF, "Endonuclease I-SceII, encoded by a mobile group I intron within the mitochondrial COX1 gene; intron is normally spliced by the BI4p maturase but AI4p can mutate to acquire the same maturase activity"
>Q0070 AI5_ALPHA SGDID:S000007265, Chr Mito from 13818-13986,16435-16470,18954-18991,20508-20984,21995-23167, Verified ORF, "Endonuclease I-SceIV, involved in intron mobility; encoded by a mobile group I intron within the mitochondrial COX1 gene"
>Q0075 AI5_BETA SGDID:S000007266, Chr Mito from 24156-24870,24906-25255, Uncharacterized ORF, "Protein of unknown function, encoded within an intron of the mitochondrial COX1 gene; translational initiation codon is predicted to be ATA rather than ATG"
>Q0080 ATP8 SGDID:S000007267, Chr Mito from 27666-27812, Verified ORF, "Subunit 8 of the F0 sector of mitochondrial inner membrane F1-F0 ATP synthase, encoded on the mitochondrial genome; ATP8 and ATP6 mRNAs are not translated in the absence of the F1 sector of ATPase"
>Q0085 ATP6 SGDID:S000007268, Chr Mito from 28487-29266, Verified ORF, "Mitochondrially encoded subunit a of the F0 sector of mitochondrial F1F0 ATP synthase; translation is specifically activated by Atp22p; ATP6 and ATP8 mRNAs are not translated in the absence of the F1 sector of ATPase"
>Q0092 Q0092 SGDID:S000007269, Chr Mito from 30874-31014, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>Q0105 COB SGDID:S000007270, Chr Mito from 36540-36954,37723-37736,39141-39217,40841-41090,42508-42558,43297-43647, Verified ORF, "Cytochrome b, mitochondrially encoded subunit of the ubiquinol-cytochrome c reductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p"
>Q0110 BI2 SGDID:S000007271, Chr Mito from 36540-36954,37723-38579, Verified ORF, "Mitochondrial mRNA maturase with a role in splicing, encoded by both exon and intron sequences of partially processed COB mRNA"
>Q0115 BI3 SGDID:S000007272, Chr Mito from 36540-36954,37723-37736,39141-40265, Verified ORF, "Mitochondrial mRNA maturase, forms a complex with Mrs1p to mediate splicing of the bI3 intron of the COB gene; encoded by both exon and intron sequences of partially processed COB mRNA"
>Q0120 BI4 SGDID:S000007273, Chr Mito from 36540-36954,37723-37736,39141-39217,40841-42251, Verified ORF, "Mitochondrial mRNA maturase, forms a complex with Nam2p to mediate splicing of the bI4 intron of the COB gene; encoded by both exon and intron sequences of partially processed COB mRNA"
>Q0130 OLI1 SGDID:S000007274, Chr Mito from 46723-46953, Verified ORF, "F0-ATP synthase subunit c (ATPase-associated proteolipid), encoded on the mitochondrial genome; mutation confers oligomycin resistance; expression is specifically dependent on the nuclear genes AEP1 and AEP2"
>Q0140 VAR1 SGDID:S000007275, Chr Mito from 48901-50097, Verified ORF, "Mitochondrial ribosomal protein of the small subunit, mitochondrially-encoded; polymorphic in different strains due to variation in number of AAT (asparagine) codons; translated near the mitochondrial inner membrane"
>Q0142 Q0142 SGDID:S000007276, Chr Mito from 51052-51228, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious open reading frame Q0143"
>Q0143 Q0143 SGDID:S000007277, Chr Mito from 51277-51429, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>Q0144 Q0144 SGDID:S000007278, Chr Mito from 54109-54438, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>Q0160 SCEI SGDID:S000007279, Chr Mito from 61022-61729, Verified ORF, "I-SceI DNA endonuclease, encoded by the mitochondrial group I intron of the 21S_rRNA gene; mediates gene conversion that propagates the intron into intron-less copies of the 21S_rRNA gene"
>Q0182 Q0182 SGDID:S000007280, Chr Mito from 65770-66174, Dubious ORF, "Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"
>Q0250 COX2 SGDID:S000007281, Chr Mito from 73758-74513, Verified ORF, "Subunit II of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits"
>Q0255 Q0255 SGDID:S000007282, Chr Mito from 74495-75622,75663-75872,75904-75984, Uncharacterized ORF, "Maturase-like protein"
>Q0275 COX3 SGDID:S000007283, Chr Mito from 79213-80022, Verified ORF, "Subunit III of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits"
>Q0297 Q0297 SGDID:S000007284, Chr Mito from 85554-85709, Dubious ORF, "Dubious open reading frame of the mitochondrial genome; unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene RPM1"
>R0010W FLP1 SGDID:S000029654, 2-micron plasmid from 252-1523, Verified ORF, "Site-specific recombinase encoded on the 2-micron plasmid, required for 2-micron plasmid propagation as part of a plasmid amplification system that compensates for any copy number decreases caused by missegregation events"
>R0020C REP1 SGDID:S000029675, 2-micron plasmid from 3008-1887, reverse complement, Verified ORF, "Master regulator that acts in concert with Rep2p to regulate transcript levels of the FLP1 gene that promotes plasmid copy amplification; autoregulates levels of its own transcript"
>R0030W RAF1 SGDID:S000029674, 2-micron plasmid from 3271-3816, Verified ORF, "Anti-repressor that increases 2 micron plasmid copy number by relieving repression of the FLP1 site-specific recombinase caused by the Rep1-Rep2p trascription regulator; also itself repressed by the Rep1p-Rep2p complex"
>R0040C REP2 SGDID:S000029676, 2-micron plasmid from 6198-5308, reverse complement, Verified ORF, "Master regulator that acts in concert with Rep1p to regulate transcript levels of the FLP1 gene that promotes plasmid copy amplification; also autoregulates levels of its own transcript"
