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BACKGROUND

The Cellular Signal Integration Group (C-SIG), http://www.lindinglab.org, is a network biology research group located at the Department of Systems Biology at the Technical University of Denmark (DTU). Our department represents one of the largest network biology centers in academia and provides a highly multi-disciplinary profile. Our lab explores biological systems by both generating high-throughput data and developing algorithms aimed at predicting cell behavior with accuracy similar to those of weather or aircraft models. A major focus of our lab is studying cellular signal processing and decision-making during cancer progression.

RESPONSIBILITIES

A PhD position is available in the Linding lab. Prof Dr Linding is a world-leading network biologist and his group is interested in the mechanisms by which cells use signaling networks to respond and adapt to changes in their environment. We are seeking a highly motivated and brilliant PhD student to join our highly dynamic, productive and stimulating lab. We are equipped with the latest orbitrap instruments, in particular fourQ Exactive mass spectrometers (Thermo Fisher Scientific), as well as state-of-the-art chromatography devices.

In this position, the successful applicant will work in a fast-paced, dynamic environment, performing large-scale integrative studies to advance research into biological and complex systems in order to develop new understanding of evolution and therapies for human diseases. The PhD student will work on projects related to our recent studies on phosphorylation networks and network medicine (Creixell et al. 2012 Nature Biotechnology, Erler & Linding Cell 2012, Bakal, Linding et al. Science 2008, Tan et al. Science 2009 and Tan et al. Science 2011 and Jørgensen et al. Science 2009). The projects involve mainly high-throughput and high-sensitivity mass-spectrometry and large-scale cell culturing, but can be extended to include High-Content Screening, sequencing and other experimental approaches. By combining quantitative phospho-proteomics with computational modeling and tumor biology, we aim to perform global modeling of biological systems and to systematically investigate dysregulation of signaling networks in cancer.

REQUIREMENTS

Candidates should hold an MSc degree or equivalent in systems biology, molecular biology, computer science, physics, chemistry or other relevant field, and have hands-on experience in mass spectrometry. Experience in large-scale/systems studies is desirable. Experience in mammalian tissue culture, quantitative proteomics or phospho-proteomics is a distinct advantage. Experience with signal transduction, bioinformatics, programming, LINUX and HPC technical computing is an additional advantage.

The post-holder must be keen to generate, analyze and computationally handle large-scale quantitative data to reach a deeper understanding of the biological question at hand. Applicants should be able to work independently and to plan and carry out complicated tasks, while also being part of a large and dynamic group. Strong communication skills in English, both written and spoken are required.

Approval and Enrolment:
The scholarships for the PhD degree are subject to academic approval, and the candidates will be enrolled in one of the general degree programmes of DTU. For information about the general requirements for enrolment and the general planning of the scholarship studies, please see the DTU PhD Guide.

COMPENSATION

DTU offers:
The C-SIG lab is part of the Center for Biological Sequence Analysis (CBS) at the Technical University of Denmark (DTU). CBS represents one of the largest systems and computational biology centers in academia and has a highly multi-disciplinary profile. DTU strives for academic excellence, collegial respect and freedom tempered by responsibility. DTU is a leading technical university in Europe and ranks with the best universities in the world. We offer a highly attractive training environment and opportunities to take part in a frontier research program combating cancer.

Salary and Appointment Terms:
The salary and appointment terms are consistent with the current rules for PhD degree students. The period of employment is 3 years.

HOW TO APPLY

Apply at http://www.career.dtu.dk

Applications must be submitted as one pdf file containing all materials to be given consideration. To apply, please open the link "Apply online," fill in the online application form, and attach all your materials in English in one pdf file. The file must include:

A letter motivating the application (cover letter) * Curriculum vitae
Grade transcripts and BSc/MSc diploma
Excel sheet with translation of grades to the Danish grading system (see guidelines and excel spreadsheet here)

Please DO NOT include reprints of papers/manuscripts in your application.

Candidates may apply prior to obtaining their master's degree, but cannot begin before having received it.

All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.

Further information:
Further information may be obtained from center administrator Dorthe Kjærsgaard, + 45 4525 2480, dorthek[at]cbs.dtu.dk

Please do not send applications to this e-mail address, instead apply online as described above.

You can read more about Rune Linding's Research Group at http://www.lindinglab.org.

DEADLINE

We must have your online application by 30 May 2013.

Discussion forums: Opportunity: PhD position in high-throughput mass-spectrometry-based proteomics @ Technical University of Denmark -- Lyngby, Denmark

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