ETS1

HOME

ETS1

OMIM	GENE CARDS	CGAP
164720	ETS1	18063

SYNONYMS

v-ets avian erythroblastosis virus E2 oncogene homolog 1

Cell Type Distribution

High expression of ets-1 gene in human thymocytes and immature T leukemic cells Sacchi-N. de-Klein-A. Showalter-S-D. Bigi-G. Papas-T-S. Leukemia 2: 12-18 (1988)

Chromosome Human

	The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21 Watson-D-K. McWilliams-Smith-M-J. Nunn-M-F. Duesberg-P-H. OBrien-S-J. Papas-T-S. Proc-Natl-Acad-Sci-U-S-A 82: 7294-7298 (1985)
	Chromosomal localization of the human proto-oncogene c-ets de-Taisne-C. Gegonne-A. Stehelin-D. Bernheim-A. Berger-R. Nature 310: 581-583 (1984)

Chromosome Mouse

The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21 Watson-D-K. McWilliams-Smith-M-J. Kozak-C. Reeves-R. Gearhart-J. Nunn-M-F. Nash-W. Fowle-J-R 3d. Duesberg-P. Papas-T-S. et al. Proc-Natl-Acad-Sci-U-S-A 83: 1792-1796 (1986)

Complementation

	Fusion of the nuclear oncoproteins v-Myb and v-Ets is required for the leukemogenicity of E26 virus Metz-T. Graf-T. Cell 66: 95-105 (1991)
	Two nuclear oncogenic proteins, P135gag-myb-ets and p61/63myc, cooperate to induce transformation of chicken neuroretina cells Amouyel-P. Laudet-V. Martin-P. Li-R-P. Quatannens-B. Stehelin-D. Saule-S. J-Virol 63: 3382-3388 (1989)

Homologue

	A Drosophila gene encoding an E-26-specific (Ets) domain protein Tei-H. Nihonmatsu-I. Yokokura-T. Ueda-R. Sano-Y. Okuda-T. Sato-K. Hirata-K. Fujita-S-C. Yamamoto-D. Proc-Natl-Acad-Sci-U-S-A 89: 6856-60 (1992)
	The Drosophila 74EF early puff contains E74, a complex ecdysone-inducible gene that encodes two ets-related proteins Burtis-K-C. Thummel-C-S. Jones-C-W. Karim-F-D. Hogness-D-S. Cell 61: 85-99 (1990)

Oncogenicity

	Hu-ets-1 gene in congenital leukemia with t(11;19)(q23;p13) Ohyashiki-K. Ohyashiki-J-H. Nomura-K. Ryan-D-H. Kinniburgh-A-J. Sandberg-A-A. Cancer-Genet-Cytogenet 30: 233-238 (1988)
	The c-ets-1 proto-oncogene is rearranged in some cases of acute lymphoblastic leukaemia Goyns-M-H. Hann-I-M. Stewart-J. Gegonne-A. Birnie-G-D. Br-J-Cancer 56: 611-613 (1987)
	Amplification and rearrangement of Hu-ets-1 in leukemia and lymphoma with involvement of 11q23 Rovigatti-U. Watson-D-K. Yunis-J-J. Science 232: 398-400 (1986)

RNA Structure

The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21 Watson-D-K. McWilliams-Smith-M-J. Nunn-M-F. Duesberg-P-H. OBrien-S-J. Papas-T-S. Proc-Natl-Acad-Sci-U-S-A 82: 7294-7298 (1985)

HOME