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KIT
OMIM | GENE CARDS | CGAP |
164920 | KIT | 81665 |
SYNONYMS | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
Biochemical Type
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Cell Location
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Chromosome Human
Localization of the human c-kit protooncogene on the q11-q12 region of chromosome 4. dAuriol-L. Mattei-M-G. Andre-C. Galibert-F. Hum-Genet 78: 374-376 (1988)
Complementation
Coexpression of stem cell factor and c-kit could be responsible for growth deregulation in a significant number of breast carcinomas. Hines SJ. Organ C. Kornstein MJ. Krystal GW. Cell Growth Differ 6: 769-779 (1995)
Function
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Gene Frequency Tumor
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Oncogenic Activation
KIT protein expression and analysis of c-kit gene mutation in adenoid cystic carcinoma. Holst VA. Marshall CE. Moskaluk CA. Frierson HF Jr Mod Pathol 12: 956-960 (1999)
Oncogenicity
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Protein Binding
Kit ligand promotes human mast cell and melanocyte hyperplasia and functional activation in vivo. Costa JJ. Demetri GD. Harrist TJ. Dvorak AM. Hayes DF. Merica EA. Menchaca DM. Gringeri AJ. Schwartz LB. Galli SJ. J Exp Med 183: 2681-2686 (1996)
Protein Structure
Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation. Vogel-W. Lammers-R. Huang-J. Ullrich-A. Science 259: 1611-1614 (1993)
Regulation
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