MYC 

Cell Type Distribution

• Expression of the c-rel and c-myc proto-oncogenes in avian tissues   Moore-B-E. Bose-H-R Jr. Oncogene 4: 845-852 (1989)

Chromosome Human

• Human c-myc onc gene is located on the region of chromosome 8  Dalla-Favera-R. Bregni-M. Erikson-J. Patterson-D. Gallo-R-C. Croce-C-M. Proc-Natl-Acad-Sci-U-S-A 79: 7824-7827 (1982)  

• Two human c-onc genes are located on the long arm of chromosome 8  Neel-B-G. Jhanwar-S-C. Chaganti-R-S. Hayward-W-S. Proc-Natl-Acad-Sci-U-S-A 79: 7842-7846 (1982)  

Chromosome Mouse

• Myc-1 is centromeric to the linkage group Ly-6--Sis--Gdc-1 on mouse chromosome 15  Huppi-K. Duncan-R. Potter-M. Immunogenetics 27: 215-219 (1988)  

• Mouse c-myc oncogene is located on chromosome 15 and translocated to chromosome 12 in plasmacytomas   Crews-S. Barth-R. Hood-L. Prehn-J. Calame-K. Science 218: 1319-1321 (1982)  

Cis-Acting Effect

• Provirus insertion exerts a long-range cis effect on the expression of Myc  Lazo-P-A. Lee-J-S. Tsichlis-P-N. Proc-Natl-Acad-Sci-U-S-A 87: 170-173 (1990)  

• Three breakpoints of variant t(2;8) translocations in Burkitt's lymphoma cells fall within a region 140 kilobases distal from c-myc  Henglein-B. Synovzik-H. Groitl-P. Bornkamm-G-W. Hartl-P. Lipp-M. Mol-Cell-Biol 9: 2105-2113 (1989)  

• A human chromosome 8 region with abnormalities in B cell, HTLV-I+ T cell and c-myc amplified tumours Mengle-Gaw-L. Rabbitts-T-H. EMBO-J 6: 1959-1965 (1987)  

Clinical

• Role of silver staining nucleolar organizer regions, proliferating cell nuclear antigen, p53, and c-myc in differentiation and prognosis  de Rosa I. Staibano S. Muzio LL. Delfino M. Lucariello A. Coppola A. De Rosa G. Scully C J Oral Pathol Med 28: 252-258 (1999)  

• TP53 and MYC gene alterations independently predict poor prognosis in breast cancer patients 

• In vitro effects of a green tea polyphenol  raki R. Inoue S. Osborne MP. Telang NT. Ann N Y Acad Sci 768: 215-222 (1995)  

• MYC rearrangements in histologically progressed follicular lymphomas Yano-T. Jaffe-E-S. Longo-D-L. Raffeld-M. Blood 80: 758-67 (1992)  

• Overexpression of c-myc constitute a common characteristic of metastatic human prostate cancer Nag-A. Smith-R-G. Prostate 15: 115-122 (1989) 

Complementation

• Cooperation of TGF alpha and c-Myc in mouse mammary tumorigenesis  Amundadottir LT. Nass SJ. Berchem GJ. Johnson MD. Dickson RB. Oncogene 13: 757-765 (1996)  

• TGF alpha and c-Myc synergize in an extremely powerful way to cause breast and salivary gland tumorigenesis in males and virgin females  Amundadottir LT. Johnson MD. Merlino G. Smith GH. Dickson RB Cell Growth Differ 6: 737-748 (1995)  

• Activated ras and myc together can induce carcinoma without p53 mutation.  Lu X. Park SH. Thompson TC. Lane DP. Cell 70: 153-161 (1992)  

• Experimental oncogene induced prostate cancer  Thompson-T-C. Kadmon-D. Timme-T-L. Merz-V-W. Egawa-S. Krebs-T. Scardino-P-T. Park-S-H. Cancer-Surv 11: 55-71 (1991)  

• Cooperation with c-myc and N-myc in murine leukemia virus-induced tumors van-Lohuizen-M. Verbeek-S. Krimpenfort-P. Domen-J. Saris-C. Radaszkiewicz-T. Berns-A. Cell 56: 673-682 (1989)  

• Both N-ras and c-myc are activated in the SHAC human stomach fibrosarcoma cell line  Andeol-Y. Nardeux-P-C. Daya-Grosjean-L. Brison-O. Cebrian-J. Suarez-H. Int-J-Cancer 41: 732-737 (1988)  

• v-mil induces autocrine growth and enhanced tumorigenicity in v-myc-transformed avian macrophages Graf-T. von-Weizsaecker-F. Grieser-S. Coll-J. Stehelin-D. Patschinsky-T. Bister-K. Bechade-C. Calothy-G. Leutz-A. Cell 45: 357-364 (1986)  

• MH2 and MC29 have very similar oncogenic properties Kan-N-C. Flordellis-C-S. Garon-C-F. Duesberg-P-H. Papas-T-S. Proc-Natl-Acad-Sci-U-S-A 80: 6566-6570 (1983)  

• A ras oncogene coexisting with altered myc genes in hematopoietic tumors  Murray-M-J. Cunningham-J-M. Parada-L-F. Dautry-F. Lebowitz-P. Weinberg-R-A. Cell 33: 749-757 (1983)  

Function

• Cooperation of TGF alpha and c-Myc in mouse mammary tumorigenesis: coordinated stimulation of growth and suppression of apoptosis  Amundadottir LT. Nass SJ. Berchem GJ. Johnson MD. Dickson RB. Oncogene 13: 757-765 (1996)  

• c-Myc induces apoptosis in epithelial cells by both p53-dependent and p53-independent mechanisms Sakamuro D. Eviner V. Elliott KJ. Showe L. White E. Prendergast GC. Oncogene 11: 2411-2418 (1995)  

• Abrogation by c-myc of G1 phase arrest induced by RB protein but not by p53  Goodrich DW. Lee WH. Nature 360: 177-179 (1992)  

• c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation  Prendergast-G-C. Lawe-D. Ziff-E-B. Cell 65: 395-407 (1991) 

• The c-myc-regulated gene mrl encodes plasminogen activator inhibitor 1  Prendergast-G-C. Diamond-L-E. Dahl-D. Cole-M-D. Mol-Cell-Biol 10: 1265-1269 (1990)  

• Regulation of cell cycle duration by c-myc levels  Karn-J. Watson-J-V. Lowe-A-D. Green-S-M. Vedeckis-W. Oncogene 4: 773-787 (1989)  

• Possible function of the c-myc product: promotion of cellular DNA replication  Iguchi-Ariga-S-M. Itani-T. Kiji-Y. Ariga-H. EMBO-J 6: 2365-2371 (1987)  

Homologue

• Presence of proteins and genes homologous to the c-myc proto-oncogene in Entamoeba  Leyva-Leyva-M. Rangel-L-M. Ayala-P. Valdes-J. Gariglio-P. Orozco-E. Arch-Invest-Med (Mex) 21 Suppl 1: 35-9 (1990)   

• Differential expression of two Xenopus c-myc proto-oncogenes during development  Vriz-S. Taylor-M. Mechali-M. EMBO-J 8: 4091-4097 (1989)  

Oncogenic  Activation

• Correlation of myc expression with the growth-arrested and transformed phenotypes in hybrids between a T lymphoma and an antigen-responsive T-cell line Kubota-K. Imreh-S. Katoh-H. Babonits-M. Wiener-F. Int-J-Cancer 51: 927-34 (1992) 

• Analysis of gene amplification in head-and-neck squamous-cell carcinoma  Leonard JH. Kearsley JH. Chenevix-Trench G. Hayward NK Int J Cancer 48: 511-515 (1991)  

Phenotype

• A clonal mouse prostate carcinoma was established by the introduction of the ras and myc oncogenes via the recombinant retrovirus Zipras/myc 9 Egawa-S. Kadmon-D. Miller-G-J. Scardino-P-T. Thompson-T-C. Mol-Carcinog 5: 52-61 (1992)  

• elevated TGF-beta 1 and beta 3 are correlated with progression to malignancy and that mesenchyme derived TGF-beta 1 may play an important role in the promotion of ras + myc-induced carcinomas  Merz-V-W. Miller-G-J. Krebs-T. Timme-T-L. Kadmon-D. Park-S-H. Egawa-S. Scardino-P-T. Thompson-T-C. Mol-Endocrinol 5: 503-513 (1991)  

• Constitutive myc plus raf expression can provoke genetic reprogramming in lymphocytes  Klinken-S-P. Alexander-W-S. Adams-J-M. Cell 53: 857-867 (1988) 

• Control of myogenic differentiation by cellular oncogenes  Schneider-M-D. Olson-E-N. Mol-Neurobiol 2: 1-39 (1988)  

• The effect of alterations in myc gene expression on B cell development in the bursa of Fabricius Thompson-C-B. Humphries-E-H. Carlson-L-M. Chen-C-L. Neiman-P-E. Cell 51: 371-381 (1987)  

Protein Structure

• High affinity DNA-binding Myc analogs: recognition by an alpha helix  Fisher-D-E. Parent-L-A. Sharp-P-A. Cell 72: 467-476 (1993) 

Regulation

• Defects in p21WAF1/CIP1, Rb, and c-myc signaling in phorbol ester-resistant cancer cells Blagosklonny MV. Prabhu NS. El-Deiry WS. Cancer Res 57: 320-325 (1997)  

• Growth arrest and non-apoptotic cell death associated with the suppression of c-myc expression  Fornari FA Jr. Jarvis DW. Grant S. Orr MS. Randolph JK. White FK. Gewirtz DA. Biochem Pharmacol 51: 931-940 (1996)  

• Molecular mechanisms in the antiproliferative action of taxol and tiazofurin  Olah E. Csokay B. Prajda N. Kote-Jarai Z. Yeh YA. Weber G. Anticancer Res 16: 2469-2477 (1996)  

• Heregulin is rapidly translocated to the nucleus and its transport is correlated with c-myc induction in breast cancer cells  Li W. Park JW. Nuijens A. Sliwkowski MX. Keller GA. Oncogene 12: 2473-2477 (1996) 

• Effects of transforming growth factor beta-1 on growth-regulatory genes in tumour-derived human oral keratinocytes  Paterson IC. Patel V. Sandy JR. Prime SS. Yeudall WA Br J Cancer 72: 922-927 (1995)  

• Expression of the protooncogene mdm2 markedly increases in response to carbon tetrachloride  Kubin T. Gohda E. Yamamoto I. Biochem Mol Biol Int 36: 393-400 (1995)  

• Glucocorticoid regulation of c-myc promoter utilization in P1798 T-lymphoma cells  Ma-T. Mahajan-P-B. Thompson-E-A. Mol-Endocrinol 6: 960-8 (1992)  

• Molecular biology of the coronary vascular and myocardial responses to ischemia   Sharma-H-S. Wunsch-M. Brand-T. Verdouw-P-D. Schaper-W. J-Cardiovasc-Pharmacol 20 Suppl 1: S23-31 (1992)  

• Transactivation of the c-myc promoter by human T cell leukemia virus type 1 tax is mediated by NF kappa B  Duyao-M-P. Kessler-D-J. Spicer-D-B. Bartholomew-C. Cleveland-J-L. Siekevitz-M. Sonenshein-G-E. J-Biol-Chem 267: 16288-91 (1992)  

• A protein-binding site in the c-myc promoter functions as a terminator of RNA polymerase II transcription  Roberts-S. Purton-T. Bentley-D-L. Genes-Dev 6: 1562-74 (1992) 

• Sensitivity of nuclear c-myc levels and induction to differentiation-inducing agents in human colon tumor cell lines   Taylor-C-W. Kim-Y-S. Childress-Fields-K-E. Yeoman-L-C. Cancer-Lett 62: 95-105 (1992)  

• Inappropriate kinetic regulation of c-myc and TGF-alpha mRNAs at quiescence may be related to the growth factor independence of the poorly differentiated colon carcinoma cells Mulder-K-M. Cancer-Res 51: 2256-2262 (1991)  

• TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains   Pietenpol-J-A. Stein-R-W. Moran-E. Yaciuk-P. Schlegel-R. Lyons-R-M. Pittelkow-M-R. Munger-K. Howley-P-M. Moses-H-L. Cell 61: 777-785 (1990)  

• Negative autoregulation of c-myc transcription  Penn-L-J. Brooks-M-W. Laufer-E-M. Land-H. EMBO-J 9: 1113-1121 (1990)  

• Effects of growth stimulatory factors on mitogenicity and c-myc expression in poorly differentiated and well differentiated human colon carcinoma cells   Mulder-K-M. Brattain-M-G. Mol-Endocrinol 3: 1215-1222 (1989)  

• Tyrosine kinase oncogenes abrogate interleukin-3 dependence of murine myeloid cells through signaling pathways involving c-myc  Cleveland-J-L. Dean-M. Rosenberg-N. Wang-J-Y. Rapp-U-R. Mol-Cell-Biol 9: 5685-5695 (1989)  

• A cis-acting element in the promoter region of the murine c-myc gene is necessary for transcriptional block   Miller-H. Asselin-C. Dufort-D. Yang-J-Q. Gupta-K. Marcu-K-B. Nepveu-A. Mol-Cell-Biol 9: 5340-5349 (1989)  

• Analysis of 3'-untranslated regions of seven c-myc genes reveals conserved elements prevalent in post-transcriptionally regulated genes  Vriz-S. Mechali-M. FEBS-Lett 251: 201-206 (1989)  

• Differential expression of two Xenopus c-myc proto-oncogenes during development  Vriz-S. Taylor-M. Mechali-M. EMBO-J 8: 4091-4097 (1989)  

• Up-regulation of c-myc in a transformed cell line approaching stationary phase growth in culture Mulder-K-M. Levine-A-E. Hinshaw-X-H. Cancer-Res 49: 2320-2326 (1989)  

• Mitogenic activation of normal T cells leads to increased initiation of transcription in the c-myc locus  Kelly-K. Siebenlist-U. J-Biol-Chem 263: 4828-4831 (1988)  

• Transcription of the c-myc oncogene is altered in spontaneously immortalized rodent fibroblasts  Tavassoli-M. Shall-S. Oncogene 2: 337-345 (1988)  

• Proto-oncogene c-myc is repressed in response to transforming growth factor-beta in a human colon carcinoma cell line  Mulder-K-M. Levine-A-E. Hernandez-X. McKnight-M-K. Brattain-D-E. Brattain-M-G. Biochem-Biophys-Res-Commun 150: 711-716 (1988)  

• An initiation site of DNA replication with transcriptional enhancer activity present upstream of the c-myc gene   Iguchi-Ariga-S-M. Okazaki-T. Itani-T. Ogata-M. Sato-Y. Ariga-H. EMBO-J 7: 3135-3142 (1988)  

• Repression of c-myc expression is associated with diminished cellular proliferation and the induction of a more benign phenotype in human colon carcinoma cells   Mulder-K-M. Brattain-M-G. Int-J-Cancer 42: 64-70 (1988)  

• Similarities and differences in the regulation of N-myc and c-myc genes in murine embryonal carcinoma cells   Sejersen-T. Rahm-M. Szabo-G. Ingvarsson-S. Sumegi-J. Exp-Cell-Res 172: 304-317 (1987)  

• A plasmacytoma-specific factor binds the c-myc promoter region   Kakkis-E. Calame-K. Proc-Natl-Acad-Sci-U-S-A 84: 7031-7035 (1987)