OMIM :  116899

GENECARD : CDKN1A

CGAP : 179665

• cyclin-dependent kinase inhibitor 1A (p21, Cip1)
• CDKN1
• SDI1
• P21
• CIP1
• CAP20
• WAF1

Biochemical type

• The cyclin-dependent kinase inhibitors p21, and to a lesser extent p27, were up-regulated just as mdm2. Muller-Hocker J, Zietz CH, Sendelhofert A.
   

Cell Cycle

• Deregulated expression of cell cycle-associated proteins in solid pseudopapillary tumor of the pancreas. Muller-Hocker J, Zietz CH, Sendelhofert A.
   

Clinical

•  The clinicopathologic significance of TGF-beta1 and p21 expression in resectable invasive ductal carcinoma (IDC) of the pancreas. Hashimoto K, Nio Y, Sumi S, Toga T, Omori H, Itakura M, Yano S.

• Evaluation of expression of p53 and WAF/1-p21 may be beneficial in the prediction of the patient's prognosis as well as prediction of the effects of adjuvant chemotherapy in pancreatic cancer patients. Nio Y, Dong M, Uegaki K, Hirahara N, Minari Y, Sasaki S, Takamura M, Iguchi C, Tamura K.
   

• Analysis of p53, p21WAF1, and TGF-beta1 in human ductal adenocarcinoma of the pancreas: TGF-beta1 protein expression predicts longer survival. Coppola D, Lu L, Fruehauf JP, Kyshtoobayeva A, Karl RC, Nicosia SV, Yeatman TJ.
  

• Inhibition of pancreatic tumor cell growth in culture by p21WAF1 recombinant adenovirus. Joshi US, Dergham ST, Chen YQ, Dugan MC, Crissman JD, Vaitkevicius VK, Sarkar FH.
  

• The clinical significance of p21(WAF1/CIP-1) and p53 expression in pancreatic adenocarcinoma. Dergham ST, Dugan MC, Joshi US, Chen YC, Du W, Smith DW, Arlauskas P, Crissman JD, Vaitkevicius VK, Sarkar FH.
   

• Clinicopathological significance of Ki-ras point mutation and p21 expression in benign and malignant exocrine tumors of the human pancreas. Song MM, Nio Y, Sato Y, Tamura K, Furuse K.
  

Oncogenecity

• p21(WAF1/CIP1), one of the cyclin-dependent kinase (Cdk) inhibitors induced by TGF-beta1, is considered a downstream effector of the growth-inhibitory function of TGF-beta1. Hashimoto K, Nio Y, Sumi S, Toga T, Omori H, Itakura M, Yano S.

• The cyclin-dependent kinase inhibitor WAF/1-p21 is induced by wild-type p53 and has been implicated as a downstream mediator of the growth-suppressing and apoptosis-promoting function of wild-type p53. Nio Y, Dong M, Uegaki K, Hirahara N, Minari Y, Sasaki S, Takamura M, Iguchi C, Tamura K.
   

• p21WAF1--a tumor suppressor gene--acts as a downstream effector of p53 function and mediates G1 cell cycle arrest by inhibiting cyclin-dependent kinases, which promote cell growth. Joshi US, Dergham ST, Chen YQ, Dugan MC, Crissman JD, Vaitkevicius VK, Sarkar FH.
   

Regulation

• Deregulation of the cell cycle with overexpression of cell cycle-activating proteins D1 and D3 and a probably counterbalancing upregulation of the cyclin-dependent kinase inhibitors p21 and p27. Muller-Hocker J, Zietz CH, Sendelhofert A.
   

• P53, MDM2 and WAF1, that were cell-cycle-related oncogene product were more strongly expressed in the nuclei of the cancer cells of the cancer tissue. Ogata M, Naito Z, Tanaka S, Moriyama Y, Asano G.
   

• p53-independent expression of the cyclin-dependent kinase inhibitor p21 in pancreatic carcinoma. DiGiuseppe JA, Redston MS, Yeo CJ, Kern SE, Hruban RH.