OMIM :  603417

GENECARD : RABIF

CGAP : 90857

• RASGRF3
• RAB interacting factor
• mss4

Chromosome human  

• Human mss4 gene was assigned to chromosome 1q32-q41. Muller-Pillasch F, Zimmerhackl F, Lacher U, Schultz N, Hameister H, Varga G, Friess H, Buchler M, Adler G, Gress TM.

Development  

• Mss4 is a critical determinant of Rab binding and nucleotide release. Zhu Z, Dumas JJ, Lietzke SE, Lambright DG.

Function  

• Mss4 is a guanine-nucleotide-exchange factor involved in the regulation of intracellular vesicular transport. Muller-Pillasch F, Zimmerhackl F, Lacher U, Schultz N, Hameister H, Varga G, Friess H, Buchler M, Adler G, Gress TM.

Protein Structure

• Structure of guanine-nucleotide-exchange factor human Mss4 and identification of its Rab-interacting surface. Yu H, Schreiber SL.

• The 1.65 A crystal structure of Mss4 reveals a network of direct and water-mediated interactions that stabilize a partially exposed structural subdomain derived from four highly conserved but nonconsecutive sequence elements. Zhu Z, Dumas JJ, Lietzke SE, Lambright DG.

Regulation

• Mss4 may be of importance for the function and growth of human tumor cells. Muller-Pillasch F, Zimmerhackl F, Lacher U, Schultz N, Hameister H, Varga G, Friess H, Buchler M, Adler G, Gress TM.

RNA structure

• Three mss4 mRNA species are transcribed in human tissues of 780, 1200, and 2800 bp. Muller-Pillasch F, Zimmerhackl F, Lacher U, Schultz N, Hameister H, Varga G, Friess H, Buchler M, Adler G, Gress TM.