OMIM :  164014

GENECARD : RELA

CGAP : 75569

SYNONYMS

• NFKB3
• v-rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (p65))
• RelA

Function

• The Rel/NF-kappaB transcription factors regulate the expression of many genes. Wang W, Abbruzzese JL, Evans DB, Chiao PJ.
   

Homolog

• The c-rel member of Rel/NF-kappa B transcription factor family was first identified as a cellular homologue of the v-rel oncogene. Wang W, Abbruzzese JL, Evans DB, Larry L, Cleary KR, Chiao PJ.
   

Oncogenecity  

• uPA with constitutive RelA activity may play a critical role in tumor invasion and metastasis. Wang W, Abbruzzese JL, Evans DB, Chiao PJ.
   

• Constitutive RelA activity may play a key role in pancreatic tumorigenesis through activation of its downstream target genes. Wang W, Abbruzzese JL, Evans DB, Larry L, Cleary KR, Chiao PJ.
   

Signaling pathway

•  RelA is constitutively activated by the upstream signaling pathway involving Ras and mitogen-activated protein kinases in pancreatic tumor cells. Wang W, Abbruzzese JL, Evans DB, Larry L, Cleary KR, Chiao PJ.