OMIM : NA

GENECARD : RPS6KB2

CGAP : 103081

• P70-BETA
• ribosomal protein S6 kinase, 70kD, polypeptide 2
• p70S6Kb
• RPS6KB2

Clinical

• Inhibitors of the constitutively active FRAP-p70s6K pathway may provide a novel therapeutic approach for pancreatic cancer. Grewe M, Gansauge F, Schmid RM, Adler G, Seufferlein T.
   

Function

• CCKB/gastrin receptor-stimulated protein synthesis likely results from an enhancement of mRNA translation and involves phosphatidyl inositol 3-kinase and p70 S6 kinase. Desbois C, Huerou-Luron IL, Dufresne M, Estival A, Clerc P, Rome V, Clemente F, Guilloteau P, Fourmy D.
   

Oncogenic activation

• FRAP-p70s6K signaling appears to be necessary for G(1)-to-S phase progression and proliferation in pancreatic cancer cells. Shah SA, Potter MW, Ricciardi R, Perugini RA, Callery MP.

Signaling pathway

• The FRAP-p70s6K signaling pathway was found to be constitutively phosphorylated/active in MiaPaCa-2 and Panc-1 human pancreatic cancer cells. Grewe M, Gansauge F, Schmid RM, Adler G, Seufferlein T.