OMIM :  138140

GENECARD : SLC2A1

CGAP : 169902

• GLUT
• GLUT1
• SLC2A1 - solute carrier family 2 (facilitated glucose transporter), member 1

Biochemical type

• Expression of glucose transporters in human pancreatic tumors compared with increased FDG accumulation in PET study. Higashi T, Tamaki N, Honda T, Torizuka T, Kimura T, Inokuma T, Ohshio G, Hosotani R, Imamura M, Konishi J.

Function

• FDG uptake, GLUT-1 glucose transporter and cellularity in human pancreatic tumors. Higashi T, Tamaki N, Torizuka T, Nakamoto Y, Sakahara H, Kimura T, Honda T, Inokuma T, Katsushima S, Ohshio G, Imamura M, Konishi J.

• Overexpression of Glut-1 mRNA suggested constitutive activation of Glut-1 gene or decreased degradation of Glut-1 mRNA in human pancreatic cancer. Reske SN, Grillenberger KG, Glatting G, Port M, Hildebrandt M, Gansauge F, Beger HG.

• GLUT-1 has a significant role in the malignant glucose metabolism. Higashi T, Tamaki N, Honda T, Torizuka T, Kimura T, Inokuma T, Ohshio G, Hosotani R, Imamura M, Konishi J.

• GLUT-I expression in pancreatic cancer cells was markedly increased, indicating that insulin enhances glucose utilization partly through increasing glucose transport. Ding XZ, Fehsenfeld DM, Murphy LO, Permert J, Adrian TE.

Phenotype

• Increased glycolysis is a characteristic metabolic feature of a malignant transformed phenotype. Reske SN, Grillenberger KG, Glatting G, Port M, Hildebrandt M, Gansauge F, Beger HG.

Regulation

• Overexpression of glucose transporter 1 and increased FDG uptake in pancreatic carcinoma. Reske SN, Grillenberger KG, Glatting G, Port M, Hildebrandt M, Gansauge F, Beger HG.