SPINT2

SYNONYMS 

• HAI-2
• Kop
• serine protease inhibitor, Kunitz type, 2
• KOP
• placental bikunin

Protein Structure

• Novel putative transmembrane protein with two Kunitz-type serine protease inhibitor domains. Muller-Pillasch F, Wallrapp C, Bartels K, Varga G, Friess H, Buchler M, Adler G, Gress TM.

Chromosome Human

• The identified gene named kop was assigned to chromosome 19 in the region 19q13.1. Muller-Pillasch F, Wallrapp C, Bartels K, Varga G, Friess H, Buchler M, Adler G, Gress TM.

Regulation

• Kunitz domain containing protein overexpressed in pancreatic cancer. Muller-Pillasch F, Wallrapp C, Bartels K, Varga G, Friess H, Buchler M, Adler G, Gress TM.

Oncogenic activation

• This new gene may participate in tumour cell invasion and metastasis. Muller-Pillasch F, Wallrapp C, Bartels K, Varga G, Friess H, Buchler M, Adler G, Gress TM.