ABCB1

 

 

OMIM :  171050

GENECARD : ABCB1

CGAP : 21330

LocusLink : 5243

 

SYNONYMS

  • PGY1
  • P-gp
  • MDR1
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • P glycoprotein 1/multiple drug resistance 1

 

 

Biochemical type

 

  • Pgp is a plasma membrane protein thought to function as an energy-dependent drug transporter. Zhang JT, Ling V.

 

 

Cell location

 

 

 

Cell type distribution

 

 

 

 

 

Clinical

 

 

  • Reversion of multidrug resistance in the P-glycoprotein-positive human pancreatic cell line (EPP85-181RDB) by introduction of a hammerhead ribozyme. Holm PS, Scanlon KJ, Dietel M.

 

 

 

Function

 

 

 

 

Protein size      

 

 

 

Protein Structure          

  • Pgp was proposed to contain 12 transmembrane domains with six extracellular loops and two cytoplasmic ATP-binding sites. Zhang JT, Ling V.