B3GALT5
SYNONYMS
Cell type distribution
The beta3GalT-V gene was mainly expressed in human small intestine and to a lesser extent in pancreas and testis. Zhou D, Berger EG, Hennet T.
Protein structure
Beta3GalT-V gene included an open reading frame of 933 bp encoding a protein of 310 amino acids. Zhou D, Berger EG, Hennet T.
Function
UDP-galactose:N-acetylglucosamine beta1, 3-galactosyltransferase(s) (beta3Gal-Ts) are required for the synthesis of the sialyl Lewis a epitope. Isshiki S, Togayachi A, Kudo T, Nishihara S, Watanabe M, Kubota T, Kitajima M, Shiraishi N, Sasaki K, Andoh T, Narimatsu H.
Beta3Gal-T5 down-regulation plays a relevant role in determining the cancer-associated glycosylation pattern of N-glycans. Salvini R, Bardoni A, Valli M, Trinchera M.
The expression of beta3GalT-V as a recombinant protein in Sf9 insect cells confirmed the galactosyltransferase activity catalyzed by this enzyme. Zhou D, Berger EG, Hennet T.
Oncogenic Activation
The beta3Gal-T5 gene is the most probable candidate responsible for the synthesis of the type 1 Lewis antigens in gastrointestinal and pancreatic epithelia and tumor cells derived therefrom. Isshiki S, Togayachi A, Kudo T, Nishihara S, Watanabe M, Kubota T, Kitajima M, Shiraishi N, Sasaki K, Andoh T, Narimatsu H.