Cell cycle 

• A link between cell cycle and cell death: Bax and Bcl-2 modulate Cdk2 activation during thymocyte apoptosis. Gil-Gomez G, Berns A, Brady HJ.

Chromosome human

• Mapping of the human BAX gene to chromosome 19q13.3-q13.4. Apte SS, Mattei MG, Olsen BR.

Clinical

• Up-regulation of p21WAF1 and Bax and down-regulation of Bcl-2 may be the molecular mechanism through which auristatin-PE inhibits cell growth and induces apoptosis. Li Y, Singh B, AliN,SarkarFH.
  

•   pBax expression may be beneficial in predicting the effects of ACT on patients with IDC. Nio Y, Iguchi C, Yamasawa K, Sasaki S, Takamura M, Toga T, Dong M, Itakura M, Tamura K.
  

DNA Structure

• The skipping of exon 3 and the resultant splicing of exons 2 and 4 maintains the original reading frame and predicts the existence of an interstitially truncated form of the major Bax protein (Bax alpha), termed Bax delta. Apte SS, Mattei MG, Olsen BR.

Function

• Bax and Bak allow cytochrome c to pass through VDAC out of liposomes, but passage is prevented by Bcl-x(L). Shimizu S, Narita M, Tsujimoto Y.
  

Gene frequency

• Frameshift mutations of hMSH3, hMLH3, BRCA-2, TGF-beta type II receptor, and BAX genes were detected in MSI-H tumors.Yamamoto H, Itoh F, Nakamura H, Fukushima H, Sasaki S, Perucho M,Imai K.
  

Homologue

• Apoptosis and occurrence of Bcl-2, Bak, Bax, Fas and FasL in the developing and adult rat endocrine pancreas. Hanke J.

Protein structure

• The C-terminus of bax is not a membrane addressing/anchoring signal. Tremblais K, Oliver L, Juin P, Le Cabellec TM, Meflah K, Vallette FM.
  

Regulation

• In mutant K-ras pancreatic carcinoma cells, programmed cell death correlates with expression and an increase, respectively, in MDA-7 and BAX proteins and increases in the ratio of BAX to BCL-2 proteins. Su Z, Lebedeva IV, Gopalkrishnan RV, Goldstein NI, Stein CA, Reed JC,Dent P,FisherPB.

• Combination of auristatin-PE and gemcitabine showed significantly greater inhibition of cell growth and up-regulated expression of p21WAF1 and Bax. Li Y, Singh B, Ali N, Sarkar FH.
  

• Prolonged survival times in patients in whom apoptosis promoting factors are upregulated indicate that apoptotic pathways are of biological significance in pancreatic cancer. Friess H, Lu Z, Graber HU, Zimmermann A, Adler G, Korc M, Schmid RM, Buchler MW.

• Both bcl-2 and bax influence the extent of apoptosis in pancreatic carcinoma. Virkajarvi N, Paakko P, Soini Y.

• Imbalance between antiapoptosis proteins (such as Bcl-2, Bcl-XL, and Mcl-1) and proapoptotic proteins (such as Bax and Bcl-Xs) is involved in the distinctive biologic features of adenocarcinomas of the pancreas. Miyamoto Y, Hosotani R, Wada M, Lee JU, Koshiba T, Fujimoto K, Tsuji S, Nakajima S, Doi R, Kato M, Shimada Y, Imamura M.

• Dynamic changes of the Bax/Bcl-2 ratio might be important in determining point of apoptosis induction in pancreatic cancer cells with p53 mutation. Wada M, Hosotani R, Lee JU, Doi R, Koshiba T, Fujimoto K, Miyamoto Y, Tsuji S, Nakajima S, Okuyama A, Imamura M.