OMIM : 123834
GENECARD : CCND3
CGAP : 83173
SYNONYMS
Cell cycle
Cyclin D3, one of the D type cyclins, has been known as a cell cycle modulator at the G1-S phase. Ito Y, Takeda T, Wakasa K, Tsujimoto M, Matsuura N.
Chromosome human
Cyclin D3, a cell cycle regulator, is encoded in the 6q21 chromosome region. Usuda H, Saito T, Emura I, Naito M.
Oncogenicity
cyclin D3, as well as cyclin D1, plays a role in the progression, including cell proliferating activity, of pancreatic adenocarcinoma. Ito Y, Takeda T, Wakasa K, Tsujimoto M, Matsuura N.
Regulation
The aberrant activation of the EGF receptor in human pancreatic cancer by amphiregulin may lead to the progression of the cell cycle via induction of cyclin D3 expression. Ebert MP, Hernberg S, Fei G, Sokolowski A, Schulz HU, Lippert H, Malfertheiner P.