OMIM : 192090

GENECARD : CDH1

CGAP : 194657

• Assignment1 of the E-cadherin gene (CDH1) to chromosome 16q22.1 by radiation hybrid mapping. Huntsman DG, Caldas C.

• Cloning and characterization of the human invasion suppressor gene E-cadherin (CDH1).
  BerxG, Staes K, van Hengel J,Molemans F,Bussemakers MJ, vanBokhovenA, van Roy F.

• UVO resides between both proximal deletion breakpoints within band 16q22.1. Natt E, Magenis RE, Zimmer J, Mansouri A, Scherer G.

• Characterization and chromosomal localization of the gene encoding the human cell adhesion molecule uvomorulin. Mansouri A, Spurr N, Goodfellow PN, Kemler R.

Clinical

• Relative expression of E-cadherin and type IV collagenase genes predicts disease outcome in patients with resectable pancreatic carcinoma. Kuniyasu H, Ellis LM, Evans DB, Abbruzzese JL, Fenoglio CJ, Bucana CD, Cleary KR, Tahara E, Fidler IJ.

• E-cadherin abnormalities and loss of physical cell-cell interaction may explain the extensively poor prognosis of the patients with pancreatic carcinoma.. Oda T, Scarpa A, Fukao K, Lemoine NR, Hirohashi S.

DNA structure

• Cloning and characterization of the human invasion suppressor gene E-cadherin (CDH1).
  BerxG, StaesK, van HengelJ, Molemans F,Bussemakers MJ, vanBokhoven A, van Roy F.

Function

• Characterization of the E-cadherin-catenin complexes in pancreatic carcinoma cell lines. El-Hariry I, Jordinson M, Lemoine N, Pignatelli M

Homologue

• Comparison of human and mouse cDNA revealed extensive homology of 82% for the nucleotide and 83% for the deduced amino acid sequence. Mansouri A, Spurr N, Goodfellow PN, Kemler R.

Oncogenic Activation

• Aberrant E-cadherin expression associated with loss of differentiation and advanced stage in human pancreatic cancer. Karayiannakis AJ, Syrigos KN, Chatzigianni E, Papanikolaou S, Alexiou D, Kalahanis N, Rosenberg T, Bastounis E

• FGF-1 and FGF-2 modulate the E-cadherin/catenin system in pancreatic adenocarcinoma cell lines. El-Hariry I, Pignatelli M, Lemoine NR.

• Loss of E-cadherin might be associated with a more invasive phenotype in pancreatic cancer. Weinel RJ, Neumann K, Kisker O, Rosendahl A.

Regulation

• Death from pancreatic cancer was significantly associated with a high MMP:E-cadherin ratio. Kuniyasu H, Ellis LM, Evans DB, Abbruzzese JL, Fenoglio CJ, Bucana CD, Cleary KR, Tahara E, Fidler IJ.

• Expression and potential role of E-cadherin in pancreatic carcinoma. Weinel RJ, Neumann K, Kisker O, Rosendahl A.