OMIM : 602909
GENECARD : CLDN4
CGAP : 5372
Genes previously mapped to the region have been located on the contig, and we have isolated eight transcripts, two of which have been characterized as the genes CPETR1 and CPETR2. Hockenhull EL, Carette MJ, Metcalfe K, Donnai D, Read AP,Tassabehji M.
Clinical
Our findings suggest that targeting claudin-4-expressing tumors with CPE represents a promising new treatment modality for pancreatic cancer and other solid tumors. Michl P, Buchholz M, Rolke M, Kunsch S, Lohr M, McClane B, Tsukita S, Leder G, Adler G, Gress TM.
Function
Multiple claudin family members are involved in the formation of TJ strands in various tissues. Morita K, Furuse M, Fujimoto K, Tsukita S.
Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability. Van Itallie C, Rahner C, Anderson JM.
The human RVP1 homologue showed differences in affinity and capacity of binding from those of the human CPE receptor. Katahira J, Sugiyama H, Inoue N, Horiguchi Y, Matsuda M, Sugimoto N
Regulation
Expression analyses showed that claudin-4 was overexpressed in most pancreatic cancer tissues and cell lines and several other gastrointestinal tumors. Michl P, Buchholz M, Rolke M, Kunsch S, Lohr M, McClane B, Tsukita S,Leder G, Adler G, Gress TM.