OMIM :  602748

GENECARD : DUSP6

CGAP : 180383

Chromosome, Human

• The DUSP6 gene is located on chromosome 12q22-23. Toyota T, Watanabe A, Shibuya H, Nankai M, Hattori E, Yamada K, Kurumaji A, Karkera JD, Detera-Wadleigh SD, Yoshikawa T.

• Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7). Smith A, Price C, Cullen M, Muda M, King A, Ozanne B, Arkinstall S, Ashworth A.

DNA Structure

• Isolation of the human genes encoding the pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases. Dowd S, Sneddon AA, Keyse SM.

• DUSP6 (alias PYST1), one of the dual-specificity tyrosine phosphatases, is localized on 12q21. Furukawa T, Yatsuoka T, Youssef EM, Abe T, Yokoyama T, Fukushige S, Soeda E, Hoshi M, Hayashi Y, Sunamura M, Kobari M, Horii A.

Function

• MAP kinases (MAPKs) are inactivated by dual specificity MAPK phosphatases. Farooq A, Chaturvedi G, Mujtaba S, Plotnikova O, Zeng L, Dhalluin C, Ashton R, Zhou MM.

• The cytosolic MAP kinase phosphatase MAP kinase phosphatase-3 (MKP-3) induces apoptosis of endothelial cells in response to tumor necrosis factor alpha (TNFalpha). Rossig L, Haendeler J, Hermann C, Malchow P, Urbich C, Zeiher AM, Dimmeler S.

• MAP kinase phosphatases are likely to be important in the regulation of diverse cellular processes such as proliferation, differentiation, and apoptosis. Smith A, Price C, Cullen M, Muda M, King A, Ozanne B, Arkinstall S, AshworthA.

• Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase. Groom LA, Sneddon AA, Alessi DR, Dowd S, Keyse SM.

Homologue

• The deduced amino acid sequence of MKP-4 is most similar to MKP-X/PYST2 (61% identity) and MKP-3/PYST1 (57% identity). Muda M, Boschert U, Smith A, Antonsson B, Gillieron C, Chabert C, Camps M, Martinou I, Ashworth A, Arkinstall S.

Oncogenicity

• Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer. Furukawa T, Yatsuoka T, Youssef EM, Abe T, Yokoyama T, Fukushige S, Soeda E,Hoshi M, Hayashi Y, Sunamura M, Kobari M, Horii A.

Regulation

• Solution structure of ERK2 binding domain of MAPK phosphatase MKP-3: structural insights into MKP-3 activation by ERK2. Farooq A, Chaturvedi G, Mujtaba S, Plotnikova O, Zeng L, Dhalluin C, Ashton R, Zhou MM.

• Nitric oxide down-regulates MKP-3 mRNA levels: involvement in endothelial cell protection from apoptosis. Rossig L, Haendeler J, Hermann C, Malchow P, Urbich C, Zeiher AM, Dimmeler S.