OMIM :  131530

GENECARD : EGF

CGAP : 2230

Cell Cycle

• Cell cycle analysis revealed an increase in cells in the S/G1 phase between 18 and 30 hours after stimulation with 50 ng/mL EGF. Poch B, Gansauge F, Schwarz A, Seufferlein T, Schnelldorfer T, Ramadani M, Beger HG, Gansauge S.

Cell Type Distribution

• Immunohistochemical localization of epidermal growth factor in the second-trimester human fetus. Poulsen SS, Kryger-Baggesen N, Nexo E.

• Expression of epidermal growth factor in human tissues. Immunohistochemical and biochemical analysis. Kajikawa K, Yasui W, Sumiyoshi H, Yoshida K, Nakayama H, Ayhan A, Yokozaki H, Ito H, Tahara E.

• Distribution and release of epidermal growth factor in man. Konturek JW, Bielanski W, Konturek SJ, Bogdal J, Oleksy J.

• Distribution and release of epidermal growth factor in man. Konturek JW, Bielanski W, Konturek SJ, Bogdal J, Oleksy J.

Clinical

• Pancreatic cancer--new aspects of molecular biology research. Kleeff J, Friess H, Berberat PO, Martignoni ME, Z'graggen K, Buchler MW.

• Enhancement of drug sensitivity of human malignancies by epidermal growth factor. Kroning R, Jones JA, Hom DK, Chuang CC, Sanga R, Los G, Howell SB, Christen RD.

Function 

• Epidermal growth factor induces cyclin D1 in human pancreatic carcinoma: evidence for a cyclin D1-dependent cell cycle progression. Poch B, Gansauge F, Schwarz A, Seufferlein T, Schnelldorfer T, Ramadani M, Beger HG, Gansauge S.

• Epidermal growth factor regulates adenylate cyclase activity via Gs and Gi1-2 proteins in pancreatic acinar membranes. Stryjek-Kaminska D, Piiper A, Zeuzem S.

• EGF and TGF-alpha may participate in the regulation of normal pancreatic exocrine function. Korc M, Chandrasekar B, Yamanaka Y, Friess H, Buchier M, Beger HG.

• Transforming growth factor alpha and epidermal growth factor in human pancreatic cancer. Barton CM, Hall PA, Hughes CM, Gullick WJ, Lemoine NR.

• Distribution, release, and secretory activity of epidermal growth factor in the pancreas. Jaworek J, Konturek SJ.

• HEGF may exert exocrine, endocrine, or paracrine functions in different tissues and at different ages. Kasselberg AG, Orth DN, Gray ME, Stahlman MT.

• Ability of human epidermal growth factor-urogastrone to form a complex with protease and the ability of human epidermal growth factor- urogastrone and secretin family members to inhibit gastric acid secretion. Scheving LA.

Gene Frequency (Tumors)

• The frequency of expression of EGF in Chinese patients with pancreatic cancer. Dong M, Nio Y, Guo KJ, Tamura K, Tian YL, Dong YT.

• Expression frequencies for EGFR, EGF, and TGF-alpha. Yamanaka Y, Friess H, Kobrin MS, Buchler M, Beger HG, Korc M.

• The immunohistochemical expressions of epidermal growth factors in human pancreatic cancer. Yamanaka Y.

• Transforming growth factor alpha and epidermal growth factor in human pancreatic cancer. Barton CM, Hall PA, Hughes CM, Gullick WJ, Lemoine NR.

Homologue

• Primary amino acid sequence similarity between human epidermal growth factor-urogastrone, human pancreatic secretory trypsin inhibitor, and members of porcine secretin family. Scheving LA.

Oncogenicity

• Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness. Yamanaka Y, Friess H, Kobrin MS, Buchler M, Beger HG, Korc M.

• The growth of pancreatic carcinoma appears to be stimulated by various factors, such as Epidermal Growth Factor. Perilli D, Mansi C, Savarino V, Celle G.

• Epidermal growth factor and its receptors in human pancreatic carcinoma. Chen YF, Pan GZ, Hou X, Liu TH, Chen J, Yanaihara C, Yanaihara N.

Regulation

• Autocrine regulatory mechanism may exist in the growth-promoting effect of EGF on tumor cells. Chen YF, Pan GZ, Hou X, Liu TH, Chen J, Yanaihara C, Yanaihara N.