OMIM :  131550

GENECARD : EGFR

CGAP : 77432

• Cellular and subcellular localization of transforming growth factor-alpha and epidermal growth factor receptor in normal and diseased human pancreas. Tomioka T, Toshkov I, Kazakoff K, Andren-Sandberg A, Takahashi T, Buchler M, Friess H, Vaughn R, Pour PM.

Cell Type Distribution

• EGF receptor (erbB1) and erbB4 were expressed mainly in islet and duct cells. Miyagawa J, Hanafusa O, Sasada R, Yamamoto K, Igarashi K, Yamamori K, Seno M, Tada H, Nammo T, Li M, Yamagata K, Nakajima H, Namba M, Kuwajima M, Matsuzawa Y.

• Developmental expression of transforming growth factor-alpha and epidermal growth factor receptor proteins in the human pancreas and digestive tract. Hormi K, Lehy T.

Clinical

• Improved gene transfer efficiency to primary and established human pancreatic carcinoma target cells via epidermal growth factor receptor and integrin-targeted adenoviral vectors. Wesseling JG, Bosma PJ, Krasnykh V, Kashentseva EA, Blackwell JL, Reynolds PN, Li H, Parameshwar M, Vickers SM, Jaffee EM, Huibregtse K, Curiel DT, Dmitriev I.

• An immunostaining panel for diagnosis of malignancy in mucinous tumors of the pancreas. Zhao J, Liang SX, Savas L, Banner BF.

• Potato carboxypeptidase inhibitor, a T-knot protein, is an epidermal growth factor antagonist that inhibits tumor cell growth. Blanco-Aparicio C, Molina MA, Fernandez-Salas E, Frazier ML, Mas JM, Querol E, Aviles FX, de Llorens R.

• Interaction of the neu/p185 and EGF receptor tyrosine kinases: implications for cellular transformation and tumor therapy. Dougall WC, Qian X, Greene MI.

• Immunohistochemical examination of EGF and EGFR and c-erbB-2 is useful in forming a prognosis for pancreatic cancer patients. Yamanaka Y.

DNA Structure

• Cloning of a variant epidermal growth factor receptor. Moriai T, Kobrin MS, Korc M.

Function

• Activation of EGF receptors plays an important role in the regulation of cell proliferation, differentiation, and survival in several different tissues. Sundaresan S, Roberts PE, King KL, Sliwkowski MX, Mather JP.

• EGFR and the p185c-neu protein serve vital roles in the transduction of differentiation,developmental, or mitogenic signaling within normal cells. Dougall WC, Qian X, Greene MI.

• Cyclin D1 overexpression in the tumor cells of pancreatic carcinoma tissue is at least partly dependent on the mitogenic effects of EGF signaling through the EGFR. Poch B, Gansauge F, Schwarz A, Seufferlein T, Schnelldorfer T, Ramadani M, Beger HG, Gansauge S.

• Transforming growth factor alpha and epidermal growth factor in human pancreatic cancer. Barton CM, Hall PA, Hughes CM, Gullick WJ, Lemoine NR.

Gene Frequency (Tumors)

• The frequency of expression of EGFR in Chinese patients with pancreatic cancer. Dong M, Nio Y, Guo KJ, Tamura K, Tian YL, Dong YT.

• The immunohistochemical expressions of epidermal growth factors, epidermal growth factor receptors and c-erbB-2 oncoprotein in human pancreatic cancer. Yamanaka Y.

Ligand Binding

• Transforming growth factor alpha and epidermal growth factor in human pancreatic cancer. Barton CM, Hall PA, Hughes CM, Gullick WJ, Lemoine NR.

Oncogenicity

• Epidermal growth factor (EGF) and its receptor (EGFR) are involved in many aspects of the development of carcinomas. Blanco-Aparicio C, Molina MA, Fernandez-Salas E, Frazier ML, Mas JM, Querol E, Aviles FX, de Llorens R.

• Role of growth factors in pancreatic cancer. Korc M.

• Expression of EGF, TGF-alpha, EGFR and c-erbB2 genes and their gene products in human pancreatic carcinoma cell lines. Chen J, Liu TH.

• The epidermal growth factor receptor in human pancreatic cancer. Lemoine NR, Hughes CM, Barton CM, Poulsom R, Jeffery RE, Kloppel G, Hall PA, Gullick WJ.

• EGFR may promote both the proliferation and the differentiation of human pancreatic carcinoma cells. Yamanaka Y, Onda M, Uchida E, Kobayashi T, Sasajima K, Tokunaga A, Tajiri T, Egami K, Asano G.

Regulation

• Inverse regulation of human ERBB2 and epidermal growth factor receptors by tumor necrosis factor alpha. Kalthoff H, Roeder C, Gieseking J, Humburg I, Schmiegel W.

Tumor Type

• Growth factor receptors are differentially expressed in cancers of the papilla of vater and pancreas. Friess H, Wang L, Zhu Z, Gerber R, Schroder M, Fukuda A, Zimmermann A, Korc M, Buchler MW.